Gautam K. Singh, M.D.  Singh_G@kids.wustl.edu

Professor of Pediatrics, Cardiology
Patient Oriented Research UnitCardiology

phone: (314) 454-6095

Education

  • BS, St. Xavier's College1970
  • MBBS, Rajendra Medical College, (Ranchi University)1977
  • MD, Patna Medical College, (Patna University)1982

Training

  • Residency in Pediatrics, Residency in Pediatric Cardiology, Senior Residency (Fellowship), Queen Charlotte and Hammersmith Hospital, The Hospital for Sick Children, London, Southhampton General Hospital of University of Southhampton, Southhampton - all in the UK1985 - 1991
  • Fellowship, St. Christopher's Hospital for Children (Temple University)1991 - 1995
  • Residency, St. Christopher's Hospital for Children (Temple University)1992 - 1993
  • Postdoctoral Research, "Gene regulation in fetal sheep heart under hemodynamic overload", Temple University, Philadelphia, PA1993 - 1994

Licensure and Board Certification

  • PA, Pennsylvia State Medical License 1991
  • American Board of Pediatrics, #052166 1993
  • NJ, New Jersey State Medical License 1994
  • MO, State Board of Registration for the Healing Arts 1995
  • Diplomate, American Board of Pediatrics and its Subboard of Pediatric Cardiology, #1451 1998
  • IL, Department of Financial and Professional Regulation 2008

Honors

  • National Merit Scholarship Awards for Academic Achievements, India
  • Outstanding Competent and Compassionate Junior Physician, St. Peter's General Hospital, Chertsey, UK
  • The Angelo M. DiGeorge Teaching Award, St. Christopher's Hospital for Children, Philadelphia, PA

Recent Publications view all (64)


Publication Co-Authors

  1. Pulmonary artery acceleration time provides an accurate estimate of invasive pulmonary hemodynamics in children. J Am Soc Echocardiogr . 2016;pii: S0894-7317(16):30422-9.. doi:doi: 10.1016/j.echo.2016.08.013.  
  2. Echocardiography of anomalous origin of the left coronary artery from the pulmonary artery. Anesthesia & Analgesia . 2016;121:1143-45. . PMID:PMID: 26484455 
  3. Toward 3D echocardiographic determination of regional myofiber structure. Ultrasound in Med. & Biol. 2016;42 (2):607–618. 
  4. 3D Printing in complex congenital heart disease: across a spectrum of age, pathology, and imaging techniques. JACC Cardiovasc Imaging. 2016;pii: S1936-878X(16)30413-2. . doi:doi: 10.1016/j.jcmg.2016.03.013.   PMID:PMID: 27450874. 
  5. KATP channel gain-of-function leads to increased cardiomyocyte L-type Ca2+ current and myocardial hypercontractility in Cantu Syndrome. Proc Natl Acad Sci U S A. 2016;113(24):6773-8. doi:doi: 10.1073/pnas  PMID:PMID: 27247394 
  6. Challenges in Interpreting Pediatric Normative Left Ventricular Strain Data and the Quest for Comprehensive Deformation Nomograms J Am Soc Echocardiogr. 2016;29(6):567-8. PMID:PMID: 27106011 
  7. Reference ranges of left ventricular strain measures by two-dimensional speckle-tracking echocardiography in children: a systematic review and meta-analysis. J Am Soc Echocardiogr . 2016;29(3):209-225. PMID:PMID: 26747685 
  8. Transplantation and mechanical circulatory support in congenital heart disease: a scientific statement from the American Heart Association; American Heart Association Adults with Congenital Heart Disease Committee of the Council on Clinical Cardiology and Council on Cardiovascular Disease in the Young, the Council on Cardiovascular Radiology and Intervention, and the Council on Functional Genomics and Translational Biology. Circulation. 2016;133(8):802-20. . doi:doi: 10.1161/CIR.0000000000000353.  PMID:PMID: 26797468 
  9. Chronic heart failure in congenital heart disease: A scientific statement from the American Heart Association; American Heart Association Council on Clinical Cardiology, Council on Functional Genomics and Translational Biology, and Council on Cardiovascular Radiology and Imaging. Circulation. 2016;133(8):770-801 . doi:doi: 10.1161/CIR.0000000000000352  PMID:PMID: 26787728. 
  10. Electrophysiological consequences of Katp gain-of-function In the heart: conduction abnormalities In Cantu Syndrome. Heart Rhythm . 2015;12(11):2316-24. doi:10.1016/j.hrthm.2015.06.042.   PMCID:26142302  PMID:PMCID: PMC4624040 
  11. Maternal post-absorptive leucine kinetics during late pregnancy in US women with HIV: a cross-sectional pilot study. Clin Nutr . 2015;10(4):e140-e146. PMCID:PMC4528644  
  12. Effects of frame rate on two-dimensional speckle tracking-derived measurements of myocardial deformation in premature infants. Echocardiography. 2015;32(5):839-47. doi:10.1111/echo.12716  PMCID:PMC4324397  PMID:25109389 
  13. Markers of cardiovascular risk, insulin resistance, and ventricular dysfunction and remodeling in obese adolescents. J Pediatr. 2015;166(3):660-5. doi:10.1016/j.jpeds.2014.11.012  PMCID:PMC4344883  PMID:25556013 
  14. Normal ranges of right ventricular systolic and diastolic strain measures in children: a systematic review and meta-analysis. J Am Soc Echocardiogr. 2014;27(5):549-60, e3. doi:10.1016/j.echo.2014.01.015  PMCID:PMC4031687  PMID:24582163 
  15. Authors' reply. J Am Soc Echocardiogr. 2014;27(3):342-3. doi:10.1016/j.echo.2013.12.015  PMID:24438750 
  16. Doppler echocardiography inaccurately estimates right ventricular pressure in children with elevated right heart pressure. J Am Soc Echocardiogr. 2014;27(3):342. doi:10.1016/j.echo.2013.11.017  PMID:24438751 
  17. Doppler echocardiography inaccurately estimates right ventricular pressure in children with elevated right heart pressure. J Am Soc Echocardiogr. 2014;27(2):163-71. doi:10.1016/j.echo.2013.09.016  PMCID:PMC3946813  PMID:24183542 
  18. Pediatric cardiac tumors: clinical and imaging features. Radiographics. 2014;34(4):1031-46. doi:10.1148/rg.344135163  PMID:25019440 
  19. Long-term cardiovascular toxicity in children, adolescents, and young adults who receive cancer therapy: pathophysiology, course, monitoring, management, prevention, and research directions: a scientific statement from the American Heart Association. Circulation. 2013;128(17):1927-95. doi:10.1161/CIR.0b013e3182a88099  PMID:24081971 
  20. Feasibility and reproducibility of systolic right ventricular strain measurement by speckle-tracking echocardiography in premature infants. J Am Soc Echocardiogr. 2013;26(10):1201-13. doi:10.1016/j.echo.2013.06.005  PMCID:PMC3800696  PMID:23880052 
  21. Chronic cyanosis due to persistent left superior vena cava draining into the left atrium in the absence of a coronary sinus. Pediatr Cardiol. 2013;34(6):1514-6. doi:10.1007/s00246-012-0620-1  PMID:23334496 
  22. KATP channels and cardiovascular disease: suddenly a syndrome. Circ Res. 2013;112(7):1059-72. doi:10.1161/CIRCRESAHA.112.300514  PMCID:PMC3660033  PMID:23538276 
  23. Reduced diastolic function and left ventricular mass in HIV-negative preadolescent children exposed to antiretroviral therapy in utero. AIDS. 2012;26(16):2053-8. doi:10.1097/QAD.0b013e328358d4d7  PMID:22874520 
  24. Novel methods for assessment of right heart structure and function in pulmonary hypertension. Clin Perinatol. 2012;39(3):685-701. doi:10.1016/j.clp.2012.06.002  PMID:22954276 
  25. Echocardiographic-based assessment of myocardial fiber structure in individual, excised hearts. Ultrason Imaging. 2012;34(3):129-41. doi:10.1177/0161734612455580  PMID:22972911 
  26. Transcatheter Ventricular Septal Defect Creation for Restrictive VSD in Double Outlet Right Ventricle Catheterization and Cardiovascular Interventions. 2012;in press. 
  27. A novel approach to non-invasive assessment of homograft form and function:a cardiac catheterization, Doppler echocardiography and CT angiography correlative study Eur Heart Journal_CV Imaging . 2012;under review. 
  28. Recurrent cardiac tamponade in a child with newly diagnosed systemic-onset juvenile idiopathic arthritis. J Clin Rheumatol . 2012;18(304-306). doi:10.1097/RHU.0b013e3182685857  PMID:22955481 
  29. Spontaneous echocardiographic contrast associated with portosystemic shunt due to persistent patent ductus venosus. Congenit Heart Dis. 2012;7(3):E18-21. doi:10.1111/j.1747-0803.2011.00587.x  PMID:22129147 
  30. To-and-fro murmur in the young due to major congenital cardiac defects: is cardiac auscultation obsolete? Cardiol Young. 2010;20(6):707-8. doi:10.1017/S1047951110001393  PMID:20887646 
  31. Accuracy and reproducibility of strain by speckle tracking in pediatric subjects with normal heart and single ventricular physiology: a two-dimensional speckle-tracking echocardiography and magnetic resonance imaging correlative study. J Am Soc Echocardiogr. 2010;23(11):1143-52. doi:10.1016/j.echo.2010.08.010  PMID:20850945 
  32. Diastolic dysfunction in pediatric cardiac patients: evaluation and management. Curr Treat Options Cardiovasc Med. 2010;12(5):503-17. doi:10.1007/s11936-010-0086-5  PMID:20842570 
  33. Development of Myocardial Tissue-Mimicking Phantoms Exhibiting a Range of Lipid Concentrations Comparable to That Observed in Obese Subjects Proc. IEEE Ultrasonics Symposium.. 2010;33(1392-1395). 
  34. Accuracy and Reproducibility of Strain by Speckle Tracking in Pediatric Subjects with Normal Heart and Single Ventricular Physiology: A 2D Speckle Tracking Echocardiography and Magnetic Resonance Imaging Correlative Study J Am Soc Echocardiogr. 2010;23(1143-52). 
  35. Intrinsic Myoarchitectural Differences between Left and Right Ventricles of Fetal Human Hearts: An ultrasonic Backscatter Study J Am Soc Echocardiogr . 2009;22(170-176). 
  36. Measurements of Ultrasonic Attenuation Properties of Mid-Gestational Fetal Pig Hearts Ultrasound in Med. & Biol. 2009;35(2:319-328). 
  37. Maturational and growth-related changes in left ventricular longitudinal strain and strain rate measured by two-dimensional speckle tracking echocardiography in healthy pediatric population J Am Soc Echocardiogr. 2008;21(1207-1215). 
  38. Pediatric Carvedilol Study Group. Carvedilot for children and adolescents with heart failure: a randomized controlled trial JAMA. 2007;12(298:1171-1179). 
  39. Regional variation in the measured apparent ultrasonic backscatter of mid-gestational fetal pig hearts Ultrasound in Medicine and Biology . 2007;33(12:1955-62). 
  40. Fetal cardiac rhabdomyoma: A sheep or a wolf J Matern Fetal Neonatal Med. 2007;20(4:343-8). 
  41. Cantu syndrome in a woman and her two daughters: Further confirmation of autosomad dominant inheritance and review of the cardiac manifestation Am J Med Genet . 2006;PartA(140A:1673-1680). 
  42. Prinzmetal angina in an adolescent: adjunctive role of tissue synchronization imaging Circulation . 2005;112(7:e91-92). 
  43. Severe aortic coarctation in infants less than 3 months: successful palliation by balloon angioplasty Invas Cardiol . 2003;(202-208). 
  44. Assessment of the coronary arteries in children: an integral part of each transthoracic echocardiographic study J Am Soc Echocardiogr . 2003;16(899-900-letter). 
  45. Aberrant coronary arteries: a reliable echocardiographic screening method J Am Soc Echocardiogr. 2003;16(756-763). 
  46. Steroid-induced hypertrophic cardiomyopathy following stem cell transplantation in a neonate: a case report Bone Marrow Transplantation . 2001;27(1105-1108). 
  47. Bridge stents in the management of obstructive vascular lesions in children Am J Cardiol . 2001;88(699-702). 
  48. Aberrant origin of the left coronary artery from the right aortic sinus: surgical intervention based on echocardiographic diagnosis. J Am Soc Echocardiogr. 2000;(13):1117-1120. 
  49. Atrial fibrillation associated with marijuana use. Pediatr Cardiol. 2000;(21):284. 
  50. Subvalvular aortic stenosis Current Treatment Option in Cardiovascular Medicine. 2000;2(6:529-35). 
  51. Five-loop coil occlusion of patent ductus arteriosus prevents recurrence of shunt at follow-up. Cathet Cardiovas Intervent. 2000;50(202-206). 
  52. Main coronary artery and coronary ostial stenosis in children: Detection by transthoracic color flow and pulsed Doppler echocardiography. J Am Soc Echocardiogr. 2000;(13):255-63. 
  53. Coronary artery to pulmonary artery pulmonary artery collaterals after heart transplant. J Heart Lung Transp. 1999;(18):1027-29. 
  54. Balloon angioplasy of long-segment aortic coarctation in the neonate. J Invas Cardiol. 1999;(11):734-38. 
  55. Differentially expressed mRNAs in fetal sheep heart under acute hemodynamic overload. Proceedings of the Second World Congress of Pediatric Cardiology and Cardiac Surgery, Imai Y and Momma K (eds), Futura Publishing Co, Inc, Armonk, NY. 1998, p100-103. 1998. 
  56. Right ventricular function and exercise performance late after primary repair of tetralogy of Fallot with transannular patch in infancy. Am J Cardiol. 1998;(81):1378-82. 
  57. Role of fetal echocardiography in the management of isolated fetal heart block with ventricular rate <55 BPM. Am J Perinatol. 1998;(15):661-68. 
  58. Diagnostic accuracy and role of intraoperative biplane transesophageal echocardiography in pediatric patients with left ventricular outflow tract lesions. J Am Soc Echocardiogr. 1998;(11):47-56. 
  59. Transcatheter management of neonates with pulmonary atresia and intact ventricular septum. Cathet Cardiovasc Diagn. 1997;(42):395-402. 
  60. Left aortic arch and right descending aorta, a rare vascular ring: diagnostic dilemma. Pediat Cardiol. 1997;(18):45-48. 
  61. Validation of right ventricular volume measurements by magnetic resonance imaging in small hearts using a fetal lamb model. 1995;(30):87-89. 
  62. Magnetic resonance measurements of volumes using a phantom: application to the cardiac ventricles of infants and small children. Invest Radiol. 1994;(29):787-789. 
  63. Study of low dosage Prostaglandin - usage and complications. 1994;(15):377-381. 
  64. Massive overdose with thyroxine - toxicity and treatment. Eur J Pediatr. 1991;(150):217-218. 
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