Gautam K. Singh, M.D.

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Professor of Pediatrics, Cardiology

phone: (314) 454-6095


  • BS, St. Xavier's College1970
  • MBBS, Rajendra Medical College, (Ranchi University)1977
  • MD, Patna Medical College, (Patna University)1982


  • Residency in Pediatrics, Residency in Pediatric Cardiology, Senior Residency (Fellowship), Queen Charlotte and Hammersmith Hospital, The Hospital for Sick Children, London, Southhampton General Hospital of University of Southhampton, Southhampton - all in the UK1985 - 1991
  • Fellowship, St. Christopher's Hospital for Children (Temple University)1991 - 1995
  • Residency, St. Christopher's Hospital for Children (Temple University)1992 - 1993
  • Postdoctoral Research, "Gene regulation in fetal sheep heart under hemodynamic overload", Temple University, Philadelphia, PA1993 - 1994

Licensure and Board Certification

  • 1991 - 1995PA, Pennsylvia State Medical License
  • 1993 - PresAmerican Board of Pediatrics, #052166
  • 1994 - 1995NJ, New Jersey State Medical License
  • 1995 - PresMO, State Board of Registration for the Healing Arts
  • 1998Diplomate, American Board of Pediatrics and its Subboard of Pediatric Cardiology, #1451
  • 2008 - PresIL, Department of Financial and Professional Regulation

Honors and Awards

  • National Merit Scholarship Awards for Academic Achievements, India
  • Outstanding Competent and Compassionate Junior Physician, St. Peter's General Hospital, Chertsey, UK
  • The Angelo M. DiGeorge Teaching Award, St. Christopher's Hospital for Children, Philadelphia, PA

Recent Publications view all (78)

  1. A novel noninvasive index to characterize right ventricle pulmonary arterial vascular coupling in children. JACC Cardiovasc Imaging. 2019;12(4):761-763. doi:10.1016/j.jcmg.2018.09.022  
  2. Echocardiographic assessment of right ventricle afterload in preterm infants: maturational patterns of pulmonary artery acceleration time over the first year of age and implications for pulmonary hypertension. J Am Soc Echocardiogr . 2019;32:884-94. doi:10.1016/j.echo.2019.03.015  
  3. . Left ventricular diastolic function influences right ventricular – pulmonary vascular coupling in premature infants Early Hum Dev. 2019;128:35-40. doi:10.1016/j.earlhumdev.2018.11.006  
  4. Potts shunt improves right ventricular function and coupling with pulmonary circulation in children with supra-systemic pulmonary arterial hypertension. Circ Cardiovasc Imaging. 2018;11(e007964.):1-10. doi:10.1161/CIRCIMAGING.118.007964  
  5. Evidence of Echocardiographic Markers of Pulmonary Vascular Disease in Asymptomatic Preterm Infants at One year of Age. J Pediatr. 2018;197::48-56.e2. doi:10.1016/j.jpeds.2018.02.006  
  6. 3D Printing is a Transformative Technology in Congenital Heart Disease: State-of-the-Art Review JACC Basic Transl Sci. 2018;3(2):294-312. doi:10.1016/j.jacbts.2017  
  7. Risk Factors and Prognostic Significance of Altered Left Ventricular Geometry in Preterm Infants. J Perinatol. 2018;38(5):543-549. doi:10.1038/s41372-018-0047-5  
  8. Right Ventricular-Pulmonary Vascular Interactions: An Emerging Role for Pulmonary Artery Acceleration Time by Echocardiography in Adults and Children. J Am Soc Echocardiogr. 2018;31(8):962-964. doi:10.1016/j.echo.2018.04.004.   
  9. Markers of maternal and infant metabolism are associated with ventricular dysfunction in infants of obese women with type 2 diabetes. Pediatr Res. 2017;38(5):543-549. doi:10.1038/pr.2017.140  PMID:28604759 
  10. Normative left ventricular m-mode echocardiographic values in preterm infants up to two kilograms. J Am Soc Echocardiogr. . 2017;2017;30(8):781-789(2017;30(8):781-789):2017;30(8):781-789. doi:. doi: 10.1016/j.echo.2017.04.010.   PMID:28599830 
  11. 3D Printing in Complex Congenital Heart Disease: Across a Spectrum of Age, Pathology, and Imaging Techniques. JACC Cardiovasc Imaging. 2017;10(8):953-956. PMID:27450874 
  12. Maturational Patterns of Systolic Ventricular Deformation Mechanics by Two-Dimensional Speckle-Tracking Echocardiography in Preterm Infants over the First Year of Age. J Am Soc Echocardiogr. 2017;30(7):685-698.e1. PMCID:PMC5495609  PMID:28433214 
  13. Tricuspid atresia with non-compaction: an early experience with implications for surgical palliation. Pediatr Cardiol. 2017;38(3):495-505. doi:10.1007/s00246-016-1541-1  PMID:27942762 
  14. Tricuspid Atresia with Non-compaction: An Early Experience with Implications for Surgical Palliation. Pediatr Cardiol. 2017;38(3):495-505. PMID:27942762 
  15. Pulmonary artery acceleration time provides an accurate estimate of invasive pulmonary hemodynamics in children. J Am Soc Echocardiogr. 2016;pii: S0894-7317(16):30422-9. doi:10.1016/j.echo.2016.08.013.  
  16. Toward 3D echocardiographic determination of regional myofiber structure. Ultrasound in Med. & Biol. 2016;42 (2):607–618. doi:10.1016/j.ultrasmedbio.2015.09.024  
  17. Neurologic and neuroimaging manifestations of Cantú syndrome: A case series. Neurology. 2016;87(3):270-6. PMCID:PMC4955281  PMID:27316244 
  18. K(ATP) channel gain-of-function leads to increased myocardial L-type Ca(2+) current and contractility in Cantu syndrome. Proc Natl Acad Sci U S A. 2016;113(24):6773-8. PMCID:PMC4914204  PMID:27247394 
  19. Challenges in Interpreting Pediatric Normative Left Ventricular Strain Data and the Quest for Comprehensive Deformation Nomograms. J Am Soc Echocardiogr. 2016;29(6):567-8. PMID:27106011 
  20. Reference Ranges of Left Ventricular Strain Measures by Two-Dimensional Speckle-Tracking Echocardiography in Children: A Systematic Review and Meta-Analysis. J Am Soc Echocardiogr. 2016;29(3):209-225.e6. PMCID:PMC4779733  PMID:26747685 
  21. Transplantation and Mechanical Circulatory Support in Congenital Heart Disease: A Scientific Statement From the American Heart Association. Circulation. 2016;133(8):802-20. PMID:26797468 
  22. Chronic Heart Failure in Congenital Heart Disease: A Scientific Statement From the American Heart Association. Circulation. 2016;133(8):770-801. PMID:26787728 
  23. Electrophysiological consequences of Katp gain-of-function In the heart: conduction abnormalities In Cantu Syndrome. Heart Rhythm . 2015;12(11):2316-24. doi:10.1016/j.hrthm.2015.06.042.   PMCID:4624040  PMID:26142302 
  24. Echocardiography of Anomalous Origin of the Left Coronary Artery from the Pulmonary Artery. Anesth Analg. 2015;121(5):1143-6. PMID:26484455 
  25. Maternal post-absorptive leucine kinetics during late pregnancy in US women with HIV: a cross-sectional pilot study. Clin Nutr . 2015;10(4):e140-e146. PMCID:PMC4528644  
  26. Effects of frame rate on two-dimensional speckle tracking-derived measurements of myocardial deformation in premature infants. Echocardiography. 2015;32(5):839-47. doi:10.1111/echo.12716  PMCID:PMC4324397  PMID:25109389 
  27. Markers of cardiovascular risk, insulin resistance, and ventricular dysfunction and remodeling in obese adolescents. J Pediatr. 2015;166(3):660-5. doi:10.1016/j.jpeds.2014.11.012  PMCID:PMC4344883  PMID:25556013 
  28. Normal ranges of right ventricular systolic and diastolic strain measures in children: a systematic review and meta-analysis. J Am Soc Echocardiogr. 2014;27(5):549-60, e3. doi:10.1016/j.echo.2014.01.015  PMCID:PMC4031687  PMID:24582163 
  29. Authors' reply. J Am Soc Echocardiogr. 2014;27(3):342-3. doi:10.1016/j.echo.2013.12.015  PMID:24438750 
  30. Doppler echocardiography inaccurately estimates right ventricular pressure in children with elevated right heart pressure. J Am Soc Echocardiogr. 2014;27(3):342. doi:10.1016/j.echo.2013.11.017  PMID:24438751 
  31. Doppler echocardiography inaccurately estimates right ventricular pressure in children with elevated right heart pressure. J Am Soc Echocardiogr. 2014;27(2):163-71. doi:10.1016/j.echo.2013.09.016  PMCID:PMC3946813  PMID:24183542 
  32. Pediatric cardiac tumors: clinical and imaging features. Radiographics. 2014;34(4):1031-46. doi:10.1148/rg.344135163  PMID:25019440 
  33. Long-term cardiovascular toxicity in children, adolescents, and young adults who receive cancer therapy: pathophysiology, course, monitoring, management, prevention, and research directions: a scientific statement from the American Heart Association. Circulation. 2013;128(17):1927-95. doi:10.1161/CIR.0b013e3182a88099  PMID:24081971 
  34. Feasibility and reproducibility of systolic right ventricular strain measurement by speckle-tracking echocardiography in premature infants. J Am Soc Echocardiogr. 2013;26(10):1201-13. doi:10.1016/j.echo.2013.06.005  PMCID:PMC3800696  PMID:23880052 
  35. Chronic cyanosis due to persistent left superior vena cava draining into the left atrium in the absence of a coronary sinus. Pediatr Cardiol. 2013;34(6):1514-6. doi:10.1007/s00246-012-0620-1  PMID:23334496 
  36. KATP channels and cardiovascular disease: suddenly a syndrome. Circ Res. 2013;112(7):1059-72. doi:10.1161/CIRCRESAHA.112.300514  PMCID:PMC3660033  PMID:23538276 
  37. Reduced diastolic function and left ventricular mass in HIV-negative preadolescent children exposed to antiretroviral therapy in utero. AIDS. 2012;26(16):2053-8. doi:10.1097/QAD.0b013e328358d4d7  PMID:22874520 
  38. Novel methods for assessment of right heart structure and function in pulmonary hypertension. Clin Perinatol. 2012;39(3):685-701. doi:10.1016/j.clp.2012.06.002  PMID:22954276 
  39. Echocardiographic-based assessment of myocardial fiber structure in individual, excised hearts. Ultrason Imaging. 2012;34(3):129-41. doi:10.1177/0161734612455580  PMID:22972911 
  40. Transcatheter Ventricular Septal Defect Creation for Restrictive VSD in Double Outlet Right Ventricle Catheterization and Cardiovascular Interventions. 2012;in press. 
  41. A novel approach to non-invasive assessment of homograft form and function:a cardiac catheterization, Doppler echocardiography and CT angiography correlative study Eur Heart Journal_CV Imaging . 2012;under review. 
  42. Recurrent cardiac tamponade in a child with newly diagnosed systemic-onset juvenile idiopathic arthritis. J Clin Rheumatol . 2012;18(304-306). doi:10.1097/RHU.0b013e3182685857  PMID:22955481 
  43. Spontaneous echocardiographic contrast associated with portosystemic shunt due to persistent patent ductus venosus. Congenit Heart Dis. 2012;7(3):E18-21. doi:10.1111/j.1747-0803.2011.00587.x  PMID:22129147 
  44. To-and-fro murmur in the young due to major congenital cardiac defects: is cardiac auscultation obsolete? Cardiol Young. 2010;20(6):707-8. doi:10.1017/S1047951110001393  PMID:20887646 
  45. Accuracy and reproducibility of strain by speckle tracking in pediatric subjects with normal heart and single ventricular physiology: a two-dimensional speckle-tracking echocardiography and magnetic resonance imaging correlative study. J Am Soc Echocardiogr. 2010;23(11):1143-52. doi:10.1016/j.echo.2010.08.010  PMID:20850945 
  46. Diastolic dysfunction in pediatric cardiac patients: evaluation and management. Curr Treat Options Cardiovasc Med. 2010;12(5):503-17. doi:10.1007/s11936-010-0086-5  PMID:20842570 
  47. Development of Myocardial Tissue-Mimicking Phantoms Exhibiting a Range of Lipid Concentrations Comparable to That Observed in Obese Subjects Proc. IEEE Ultrasonics Symposium.. 2010;33(1392-1395). 
  48. Accuracy and Reproducibility of Strain by Speckle Tracking in Pediatric Subjects with Normal Heart and Single Ventricular Physiology: A 2D Speckle Tracking Echocardiography and Magnetic Resonance Imaging Correlative Study J Am Soc Echocardiogr. 2010;23(1143-52). 
  49. Intrinsic Myoarchitectural Differences between Left and Right Ventricles of Fetal Human Hearts: An ultrasonic Backscatter Study J Am Soc Echocardiogr . 2009;22(170-176). 
  50. Measurements of Ultrasonic Attenuation Properties of Mid-Gestational Fetal Pig Hearts Ultrasound in Med. & Biol. 2009;35(2:319-328). 
  51. Maturational and growth-related changes in left ventricular longitudinal strain and strain rate measured by two-dimensional speckle tracking echocardiography in healthy pediatric population J Am Soc Echocardiogr. 2008;21(1207-1215). 
  52. Pediatric Carvedilol Study Group. Carvedilot for children and adolescents with heart failure: a randomized controlled trial JAMA. 2007;12(298:1171-1179). 
  53. Regional variation in the measured apparent ultrasonic backscatter of mid-gestational fetal pig hearts Ultrasound in Medicine and Biology . 2007;33(12:1955-62). 
  54. Fetal cardiac rhabdomyoma: A sheep or a wolf J Matern Fetal Neonatal Med. 2007;20(4:343-8). 
  55. Cantu syndrome in a woman and her two daughters: Further confirmation of autosomad dominant inheritance and review of the cardiac manifestation Am J Med Genet . 2006;PartA(140A:1673-1680). 
  56. Prinzmetal angina in an adolescent: adjunctive role of tissue synchronization imaging Circulation . 2005;112(7:e91-92). 
  57. Severe aortic coarctation in infants less than 3 months: successful palliation by balloon angioplasty Invas Cardiol . 2003;(202-208). 
  58. Assessment of the coronary arteries in children: an integral part of each transthoracic echocardiographic study J Am Soc Echocardiogr . 2003;16(899-900-letter). 
  59. Aberrant coronary arteries: a reliable echocardiographic screening method J Am Soc Echocardiogr. 2003;16(756-763). 
  60. Steroid-induced hypertrophic cardiomyopathy following stem cell transplantation in a neonate: a case report Bone Marrow Transplantation . 2001;27(1105-1108). 
  61. Bridge stents in the management of obstructive vascular lesions in children Am J Cardiol . 2001;88(699-702). 
  62. Aberrant origin of the left coronary artery from the right aortic sinus: surgical intervention based on echocardiographic diagnosis. J Am Soc Echocardiogr. 2000;(13):1117-1120. 
  63. Atrial fibrillation associated with marijuana use. Pediatr Cardiol. 2000;(21):284. 
  64. Subvalvular aortic stenosis Current Treatment Option in Cardiovascular Medicine. 2000;2(6:529-35). 
  65. Five-loop coil occlusion of patent ductus arteriosus prevents recurrence of shunt at follow-up. Cathet Cardiovas Intervent. 2000;50(202-206). 
  66. Main coronary artery and coronary ostial stenosis in children: Detection by transthoracic color flow and pulsed Doppler echocardiography. J Am Soc Echocardiogr. 2000;(13):255-63. 
  67. Coronary artery to pulmonary artery pulmonary artery collaterals after heart transplant. J Heart Lung Transp. 1999;(18):1027-29. 
  68. Balloon angioplasy of long-segment aortic coarctation in the neonate. J Invas Cardiol. 1999;(11):734-38. 
  69. Differentially expressed mRNAs in fetal sheep heart under acute hemodynamic overload. Proceedings of the Second World Congress of Pediatric Cardiology and Cardiac Surgery, Imai Y and Momma K (eds), Futura Publishing Co, Inc, Armonk, NY. 1998, p100-103. 1998. 
  70. Right ventricular function and exercise performance late after primary repair of tetralogy of Fallot with transannular patch in infancy. Am J Cardiol. 1998;(81):1378-82. 
  71. Role of fetal echocardiography in the management of isolated fetal heart block with ventricular rate <55 BPM. Am J Perinatol. 1998;(15):661-68. 
  72. Diagnostic accuracy and role of intraoperative biplane transesophageal echocardiography in pediatric patients with left ventricular outflow tract lesions. J Am Soc Echocardiogr. 1998;(11):47-56. 
  73. Transcatheter management of neonates with pulmonary atresia and intact ventricular septum. Cathet Cardiovasc Diagn. 1997;(42):395-402. 
  74. Left aortic arch and right descending aorta, a rare vascular ring: diagnostic dilemma. Pediat Cardiol. 1997;(18):45-48. 
  75. Validation of right ventricular volume measurements by magnetic resonance imaging in small hearts using a fetal lamb model. 1995;(30):87-89. 
  76. Magnetic resonance measurements of volumes using a phantom: application to the cardiac ventricles of infants and small children. Invest Radiol. 1994;(29):787-789. 
  77. Study of low dosage Prostaglandin - usage and complications. 1994;(15):377-381. 
  78. Massive overdose with thyroxine - toxicity and treatment. Eur J Pediatr. 1991;(150):217-218. 
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