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Toshifumi Sugatani, D.D.S., Ph.D.
sugatani_T@wustl.edu
Assistant Professor in Pediatrics, Nephrology
Nephrology
phone: (314) 286-1574
Education
DDS,
Asahi University School of Dentistry
,
1991
PhD,
Mie University, School of Medicine
,
2003
DDS,
Mie Univ School of Medicine
,
1993
DDS,
Mie University School of Medicine
,
2002
Honors and Awards
American Society for Bone and Mineral Research Young Investigator Award
,
2004
American Society for Bone and Mineral Research Travel Award
,
2007
North American Grant Award (Exiqon)
,
2009
Recent Publications
view all (25)
Publication Co-Authors
Keith A. Hruska, M.D.
Sugatani T.
Systemic Activation of Activin A Signaling Causes Chronic Kidney Disease-Mineral Bone Disorder.
Int J Mol Sci
.
2018;19
(9).
PMID:
30142896
Williams MJ, Sugatani T, Agapova OA, Fang Y, Gaut JP, Faugere MC, Malluche HH, Hruska KA.
The activin receptor is stimulated in the skeleton, vasculature, heart, and kidney during chronic kidney disease.
Kidney Int
.
2017.
PMID:
28843411
Hruska KA, Sugatani T, Agapova O, Fang Y.
The chronic kidney disease - Mineral bone disorder (CKD-MBD): Advances in pathophysiology.
Bone
.
2017;100:80-86.
PMCID:
PMC5502716
PMID:
28119179
Sugatani T, Agapova OA, Fang Y, Berman AG, Wallace JM, Malluche HH, Faugere MC, Smith W, Sung V, Hruska KA.
Ligand trap of the activin receptor type IIA inhibits osteoclast stimulation of bone remodeling in diabetic mice with chronic kidney disease.
Kidney Int
.
2017;91
(1):
86-95.
PMCID:
PMC5530394
PMID:
27666759
Agapova OA, Fang Y, Sugatani T, Seifert ME, Hruska KA..
Ligand trap for the activin type IIA receptor protects against vascular disease and renal fibrosis in mice with chronic kidney disease.
Kidney Int
.
2016;89
(6):
1231-43.
doi:
10.1016/j.kint.2016.02.002.
PMID:
27165838
Sugatani T, Agapova O, Malluche HH, Hruska KA.
SIRT6 deficiency culminates in low-turnover osteopenia.
Bone
.
2015;81:168-177.
doi:
10.1016/j.bone.2015.07.018
PMID:
26189760
Hruska KA, Seifert M, Sugatani T.
Pathophysiology of the chronic kidney disease-mineral bone disorder.
Curr Opin Nephrol Hypertens
.
2015;24
(4):
303-9.
PMCID:
PMC4699443
PMID:
26050115
Fang Y, Ginsberg C, Seifert M, Agapova O, Sugatani T, Register TC, Freedman BI, Monier-Faugere MC, Malluche H, Hruska KA.
CKD-induced wingless/integration1 inhibitors and phosphorus cause the CKD-mineral and bone disorder.
J Am Soc Nephrol
.
2014;25
(8):
1760-73.
doi:
10.1681/ASN.2013080818
PMCID:
PMC4116062
PMID:
24578135
Sugatani T, Hildreth BE 3rd, Toribio RE, Malluche HH, Hruska KA.
Expression of DGCR8-dependent microRNAs is indispensable for osteoclastic development and bone-resorbing activity.
J Cell Biochem
.
2014;115
(6):
1043-7.
doi:
10.1002/jcb.24759
PMCID:
PMC4079251
PMID:
24420069
Fang Y, Ginsberg C, Sugatani T, Monier-Faugere MC, Malluche H, Hruska KA.
Early chronic kidney disease-mineral bone disorder stimulates vascular calcification.
Kidney Int
.
2014;85
(1):
142-50.
doi:
10.1038/ki.2013.271
PMCID:
PMC3836911
PMID:
23884339
Sugatani T, Hruska KA.
Down-regulation of miR-21 biogenesis by estrogen action contributes to osteoclastic apoptosis.
J Cell Biochem
.
2013;114
(6):
1217-22.
doi:
10.1002/jcb.24471
PMID:
23238785
Hruska K, Mathew S, Lund R, Fang Y, Sugatani T.
Cardiovascular risk factors in chronic kidney disease: does phosphate qualify?
Kidney Int Suppl
.
2011;(121):S9-13.
PMCID:
PMC3260961
PMID:
21346719
Sugatani T, Vacher J, Hruska KA.
A microRNA expression signature of osteoclastogenesis.
Blood
.
2011;117
(13):
3648-57.
doi:
10.1182/blood-2010-10-311415
PMCID:
PMC3072882
PMID:
21273303
Sugatani T, Hruska KA.
Impaired micro-RNA pathways diminish osteoclast differentiation and function.
J Biol Chem
.
2009;284
(7):
4667-78.
doi:
10.1074/jbc.M805777200
PMCID:
PMC2640963
PMID:
19059913
Mathew S, Tustison KS, Sugatani T, Chaudhary LR, Rifas L, Hruska KA.
The mechanism of phosphorus as a cardiovascular risk factor in CKD.
J Am Soc Nephrol
.
2008;19
(6):
1092-105.
doi:
10.1681/ASN.2007070760
PMCID:
PMC2396927
PMID:
18417722
Sugatani T, Hruska KA.
MicroRNA-223 is a key factor in osteoclast differentiation.
J Cell Biochem
.
2007;101
(4):
996-9.
doi:
10.1002/jcb.21335
PMID:
17471500
Sugatani T, Hruska KA.
Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors.
J Biol Chem
.
2005;280
(5):
3583-9.
doi:
10.1074/jbc.M410480200
PMID:
15545269
Sugatani T, Alvarez UM, Hruska KA.
Activin A stimulates IkappaB-alpha/NFkappaB and RANK expression for osteoclast differentiation, but not AKT survival pathway in osteoclast precursors.
J Cell Biochem
.
2003;90
(1):
59-67.
doi:
10.1002/jcb.10613
PMID:
12938156
Sugatani T, Alvarez U, Hruska KA.
PTEN regulates RANKL- and osteopontin-stimulated signal transduction during osteoclast differentiation and cell motility.
J Biol Chem
.
2003;278
(7):
5001-8.
doi:
10.1074/jbc.M209299200
PMID:
12460992
Murata T, Sugatani T, Shimizu K, Manganiello VC, Tagawa T.
Effect of the phosphodiesterase 4 inhibitor, rolipram, on retinoic acid-increased alkaline phosphatase activity in the mouse fibroblastic C3H10T1/2 cell line.
Arch Oral Biol
.
2003;48
(1):
63-7.
PMID:
12615143
Murata T, Sugatani T, Manganiello VC, Shimizu K, Tagawa T.
Expression of phosphodiesterase 3 in rat submandibular gland cell lines.
Arch Oral Biol
.
2001;46
(5):
453-7.
PMID:
11286810
Murata T, Sugatani T, Shimizu K, Manganiello VC, Tagawa T.
Phosphodiesterase 3 as a potential target for therapy of malignant tumors in the submandibular gland.
Anticancer Drugs
.
2001;12
(1):
79-83.
PMID:
11272291
Murata T, Sugatani T, Tagawa T.
Expression of phosphodiesterase 3 in rat submandibular gland.
Arch Oral Biol
.
2000;45
(12):
1043-7.
PMID:
11084143
Nomura J, Tagawa T, Seki Y, Mori A, Nakagawa T, Sugatani T.
Kinky hair disease with multiple eruption cysts: a case report.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
.
1996;82
(5):
537-40.
PMID:
8936518
Sugatani T, Inui M, Tagawa T, Seki Y, Mori A, Yoneda J.
Myofibroma of the mandible. Clinicopathologic study and review of the literature.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
.
1995;80
(3):
303-9.
PMID:
7489274
Last updated: 08/10/2020
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