Toshifumi Sugatani, Ph.D.

Instructor in Pediatrics, Nephrology
Researcher, Pathobiology

phone: (314) 286-1574


  • DDS, Asahi University School of Dentistry1991
  • PhD, Mie University, School of Medicine2003
  • DDS, Mie Univ School of Medicine1993
  • DDS, Mie University School of Medicine2002


  • American Society for Bone and Mineral Research Young Investigator Award2004
  • American Society for Bone and Mineral Research Travel Award2007
  • North American Grant Award (Exiqon)2009

Recent Publications view all (21)

Publication Co-Authors

  1. A Ligand Trap of the Activin Receptor Type IIA Inhibits Osteoclast Stimulation of Bone Remodeling in Diabetic Mice with CKD Kidney Int. 2016. 
  2. Ligand trap for the activin type IIA receptor protects against vascular disease and renal fibrosis in mice with chronic kidney disease. Kidney Int. 2016;89(6):1231-43. doi:10.1016/j.kint.2016.02.002.  PMID:27165838 
  3. SIRT6 deficiency culminates in low-turnover osteopenia. Bone. 2015;81:168-177. doi:10.1016/j.bone.2015.07.018  PMID:26189760 
  4. Pathophysiology of the chronic kidney disease-mineral bone disorder. Curr Opin Nephrol Hypertens. 2015;24(4):303-9. doi:10.1097/MNH.0000000000000132  PMID:26050115 
  5. CKD-induced wingless/integration1 inhibitors and phosphorus cause the CKD-mineral and bone disorder. J Am Soc Nephrol. 2014;25(8):1760-73. doi:10.1681/ASN.2013080818  PMCID:PMC4116062  PMID:24578135 
  6. Expression of DGCR8-dependent microRNAs is indispensable for osteoclastic development and bone-resorbing activity. J Cell Biochem. 2014;115(6):1043-7. doi:10.1002/jcb.24759  PMCID:PMC4079251  PMID:24420069 
  7. Early chronic kidney disease-mineral bone disorder stimulates vascular calcification. Kidney Int. 2014;85(1):142-50. doi:10.1038/ki.2013.271  PMCID:PMC3836911  PMID:23884339 
  8. Down-regulation of miR-21 biogenesis by estrogen action contributes to osteoclastic apoptosis. J Cell Biochem. 2013;114(6):1217-22. doi:10.1002/jcb.24471  PMID:23238785 
  9. A microRNA expression signature of osteoclastogenesis. Blood. 2011;117(13):3648-57. doi:10.1182/blood-2010-10-311415  PMCID:PMC3072882  PMID:21273303 
  10. Impaired micro-RNA pathways diminish osteoclast differentiation and function. J Biol Chem. 2009;284(7):4667-78. doi:10.1074/jbc.M805777200  PMCID:PMC2640963  PMID:19059913 
  11. The mechanism of phosphorus as a cardiovascular risk factor in CKD. J Am Soc Nephrol. 2008;19(6):1092-105. doi:10.1681/ASN.2007070760  PMCID:PMC2396927  PMID:18417722 
  12. MicroRNA-223 is a key factor in osteoclast differentiation. J Cell Biochem. 2007;101(4):996-9. doi:10.1002/jcb.21335  PMID:17471500 
  13. Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors. J Biol Chem. 2005;280(5):3583-9. doi:10.1074/jbc.M410480200  PMID:15545269 
  14. Activin A stimulates IkappaB-alpha/NFkappaB and RANK expression for osteoclast differentiation, but not AKT survival pathway in osteoclast precursors. J Cell Biochem. 2003;90(1):59-67. doi:10.1002/jcb.10613  PMID:12938156 
  15. PTEN regulates RANKL- and osteopontin-stimulated signal transduction during osteoclast differentiation and cell motility. J Biol Chem. 2003;278(7):5001-8. doi:10.1074/jbc.M209299200  PMID:12460992 
  16. Effect of the phosphodiesterase 4 inhibitor, rolipram, on retinoic acid-increased alkaline phosphatase activity in the mouse fibroblastic C3H10T1/2 cell line. Arch Oral Biol. 2003;48(1):63-7. PMID:12615143 
  17. Expression of phosphodiesterase 3 in rat submandibular gland cell lines. Arch Oral Biol. 2001;46(5):453-7. PMID:11286810 
  18. Phosphodiesterase 3 as a potential target for therapy of malignant tumors in the submandibular gland. Anticancer Drugs. 2001;12(1):79-83. PMID:11272291 
  19. Expression of phosphodiesterase 3 in rat submandibular gland. Arch Oral Biol. 2000;45(12):1043-7. PMID:11084143 
  20. Kinky hair disease with multiple eruption cysts: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996;82(5):537-40. PMID:8936518 
  21. Myofibroma of the mandible. Clinicopathologic study and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;80(3):303-9. PMID:7489274 
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