Stuart C. Sweet, M.D., Ph.D.  scsweet@wustl.edu

W. McKim Marriott Professor of Pediatrics, Division of Allergy, Immunology and Pulmonary Medicine
Medical Director, Pediatric Lung Transplant Program, Division of Allergy, Immunology, and Pulmonary Medicine
Patient Oriented Research UnitAllergy, Immunology and Pulmonary Medicine

phone: (314) 454-2694

Clinical Interests

Dr. Sweet received his undergraduate, graduate and medical degrees at the University of Michigan. He was pediatric resident and pediatric pulmonology fellow at Washington University before joining the faculty in 1996. Dr. Sweet became medical director of the Pediatric Lung Transplant Program in 1999. He is board certified in Pediatric Pulmonology by the American Board of Pediatrics. Past honors include the Parker B. Francis Fellowship in Pulmonary Research, Scholar of the Child Health Research Center of Excellence in Developmental Biology, Washington University, Medical Scientist Award for Excellence, University of Michigan. Professional Societies include the International Society for Heart and Lung Transplantation, the American Thoracic Society and the American Academy of Pediatrics. Dr. Sweet's primary research is focused on improved understanding of the important factors determining outcome after lung transplantation in children. He is PI of an NIH funded multicenter collaborative study of the role B-cell immunity plays in lung transplant outcomes.Dr. Sweet has been Chair of the Organ Transplantation and Procurement Network (OPTN) / United Network for Organ Sharing (UNOS) Pediatric Transplantation Committee and Policy Oversight Committee and Secretary of the Board of Directors of the OPTN/UNOS, He is currently Secretary/Treasurer of the International Society for Heart and Lung Transplantation and Immediate Past President of the Missouri Chapter of the American Academy of Pediatrics. Dr. Sweet's other interests include ethics and policies related to organ allocation and the use of information technology in medicine.

Education

  • BS, University of Michigan College of Literature, Science and Arts1981
  • PhD, University of Michigan Horace H. Rackham School of Graduate Studies1989
  • MD, University of Michigan Medical School1990

Training

  • Research Fellow, University of Michigan Medical School1989 - 1990
  • House Officer, University of Michigan Medical School 1990 - 1990
  • Pediatric Resident, St. Louis Children's Hospital1990 - 1993
  • Pediatric Pulmonology Fellow, St. Louis Children's Hospital, Washington University School of Medicine1993 - 1996

Licensure and Board Certification

  • American Board of Pediatrics (recertified 2000, expired 2007) 1993
  • MO, 1995
  • American Board of Pediatrics, Sub Board of Pediatric Pulmonology (recertified 2015) 1998

Honors

  • Freshman Chemistry Achievement Award, University of Michigan1978
  • William J. Branstrom Freshman Prize, University of Michigan1978
  • James B. Angell Scholar, University of Michigan1979 - 1980
  • Class Honors, University of Michigan1979 - 1981
  • Phi Beta Kappa1980
  • B.S. (chemistry) with highest distinction, highest honors in chemistry and high honors in physics, University of Michigan1981
  • Roger B. Vanko Memorial Award for outstanding honors chemistry major, University of Michigan1981
  • Society of Nuclear Medicine student fellowship1982
  • Fellow, Medical Scientist Training Program, University of Michigan1982 - 1989
  • Burton L. Baker Cancer Research Fellowship, Michigan Cancer Institute1986 - 1987
  • M.D. with distinction in research, University of Michigan1989
  • Medical Scientist Award for Excellence, University of Michigan1990
  • Scholar of the Child Health Research Center of Excellence in Developmental Biology, Washington University1996 - 1997
  • Parker B. Francis Fellowship in Pulmonary Research1996 - 1997

Recent Publications view all (102)


  1. Assessing the impact of program volume and composition on waiting list outcomes in pediatric lung transplantation. J Heart Lung Transplant. 2017;36(11):1180-1182. PMID:28705645 
  2. The impact of conventional and nonconventional inhalants on children and adolescents. Pediatr Pulmonol. 2017. PMID:29084362 
  3. Anellovirus loads are associated with outcomes in pediatric lung transplantation. Pediatr Transplant. 2017. PMID:29082660 
  4. Risk and outcomes of pulmonary fungal infection after pediatric lung transplantation. Clin Transplant. 2017. PMID:28871606 
  5. Epstein-Barr viral loads do not predict post-transplant lymphoproliferative disorder in pediatric lung transplant recipients: A multicenter prospective cohort study. Pediatr Transplant. 2017;21(6). PMCID:PMC5568922  PMID:28639398 
  6. Pediatric Lung Transplantation. Respir Care. 2017;62(6):776-798. PMID:28546378 
  7. Outcomes of Lung Transplantation for Infants and Children with Genetic Disorders of Surfactant Metabolism. J Pediatr. 2017;184:157-164.e2. PMCID:PMC5443678  PMID:28215425 
  8. What makes a good pediatric transplant lung: Insights from in vivo lung morphometry with hyperpolarized 3 He magnetic resonance imaging. Pediatr Transplant. 2017;21(3). PMCID:PMC5378594  PMID:28120553 
  9. Improved waitlist and transplant outcomes for pediatric lung transplantation after implementation of the lung allocation score. J Heart Lung Transplant. 2017;36(5):520-528. PMID:27866928 
  10. Transplant center volume and outcomes in lung transplantation for cystic fibrosis. Transpl Int. 2017;30(4):371-377. PMID:28012223 
  11. Role of Circulating microRNAs in the Immunopathogenesis of Rejection Following Pediatric Lung Transplantation. Transplantation. 2016. PMCID:PMC5462875  PMID:27941431 
  12. Antibody-mediated rejection of the lung: A consensus report of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2016;35(4):397-406. PMID:27044531 
  13. Recommendations for utilization of the paracorporeal lung assist device in neonates and young children with pulmonary hypertension. Pediatr Transplant. 2016;20(2):256-70. doi:10.1111/petr.12673  PMID:26899454 
  14. Perceived barriers to medication adherence in pediatric and adolescent solid organ transplantation. Pediatr Transplant. 2016;20(2):307-15. PMID:26670870 
  15. Current State of Pediatric Lung Transplantation. Lung. 2015;193(5):629-37. doi:10.1007/s00408-015-9765-z  PMID:26238859 
  16. The International Society for Heart and Lung Transplantation Registries in the Era of Big Data With Global Reach. J Heart Lung Transplant. 2015;34(10):1225-32. doi:10.1016/j.healun.2015.08.001  PMID:26454736 
  17. Diffuse Lung Disease in Biopsied Children 2 to 18 Years of Age. Application of the chILD Classification Scheme. Ann Am Thorac Soc. 2015;12(10):1498-505. PMCID:PMC4627419  PMID:26291470 
  18. Electronic Cigarette Use in Middle and High School Students Triples from 2013 to 2014. Am J Respir Crit Care Med. 2015;192(3):276-8. doi:10.1164/rccm.201505-0898ED  PMID:26230233 
  19. Pediatric Deceased Donation-A Report of the Transplantation Society Meeting in Geneva. Transplantation. 2015. doi:10.1097/TP.0000000000000758  PMID:25996634 
  20. Bronchiolitis obliterans syndrome is not specific for bronchiolitis obliterans in pediatric lung transplant. J Heart Lung Transplant. 2015;34(4):516-21. doi:10.1016/j.healun.2014.10.004  PMID:25499141 
  21. Multicenter comparison of laboratory performance in cytomegalovirus and Epstein-Barr virus viral load testing using international standards. Clin Transplant. 2014;28(12):1416-23. doi:10.1111/ctr.12473  PMID:25303316 
  22. Paracorporeal lung assist devices as a bridge to recovery or lung transplantation in neonates and young children. J Thorac Cardiovasc Surg. 2014;147(1):420-6. doi:10.1016/j.jtcvs.2013.08.078  PMID:24199759 
  23. Rationing lung transplants. N Engl J Med. 2013;369(21):2064-5. doi:10.1056/NEJMc1311946#SA1  PMID:24256395 
  24. An official American Thoracic Society clinical practice guideline: classification, evaluation, and management of childhood interstitial lung disease in infancy. Am J Respir Crit Care Med. 2013;188(3):376-94. PMCID:PMC3778735  PMID:23905526 
  25. Measurement of donor-specific HLA antibodies following plasma exchange therapy predicts clinical outcome in pediatric heart and lung transplant recipients with antibody-mediated rejection. J Clin Apher. 2013;28(4):301-8. doi:10.1002/jca.21270  PMID:23426730 
  26. Induction therapy in lung transplantation. Transpl Int. 2013;26(7):696-703. doi:10.1111/tri.12115  PMID:23701023 
  27. Lung transplant is a viable treatment option for patients with congenital and acquired pulmonary vein stenosis. J Heart Lung Transplant. 2013;32(6):621-5. doi:10.1016/j.healun.2013.03.002  PMID:23701851 
  28. Neonatal paracorporeal lung assist device for respiratory failure. Ann Thorac Surg. 2013;95(2):692-4. doi:10.1016/j.athoracsur.2012.05.128  PMID:23336880 
  29. Body mass index and its effect on outcome in children after lung transplantation. J Heart Lung Transplant. 2013;32(2):196-201. doi:10.1016/j.healun.2012.11.002  PMID:23200225 
  30. Human polyomaviruses in children undergoing transplantation, United States, 2008-2010. Emerg Infect Dis. 2012;18(10):1676-9. doi:10.3201/eid1810.120359  PMCID:PMC3471627  PMID:23017293 
  31. RSV prevention and treatment in pediatric lung transplant patients: a survey of current practices among the International Pediatric Lung Transplant Collaborative. Pediatr Transplant. 2012;16(6):638-44. doi:10.1111/j.1399-3046.2012.01744.x  PMID:22738242 
  32. Report of a consensus conference on transplant program quality and surveillance. Am J Transplant. 2012;12(8):1988-96. doi:10.1111/j.1600-6143.2012.04130.x  PMID:22682114 
  33. Lung transplantation in children with idiopathic pulmonary arterial hypertension: an 18-year experience. J Heart Lung Transplant. 2011;30(10):1148-52. doi:10.1016/j.healun.2011.04.009  PMID:21620736 
  34. First experience with a paracorporeal artificial lung in a small child with pulmonary hypertension. J Thorac Cardiovasc Surg. 2011;141(6):e48-50. doi:10.1016/j.jtcvs.2011.02.005  PMID:21420104 
  35. Extracorporeal membrane oxygenation in pediatric lung transplantation. J Thorac Cardiovasc Surg. 2010;140(2):427-32. doi:10.1016/j.jtcvs.2010.04.012  PMID:20538306 
  36. Minimal acute rejection in pediatric lung transplantation--does it matter? Pediatr Transplant. 2010;14(4):534-9. doi:10.1111/j.1399-3046.2009.01268.x  PMCID:PMC2888626  PMID:20059725 
  37. Lung transplantation in the United States, 1999-2008. Am J Transplant. 2010;10(4 Pt 2):1047-68. doi:10.1111/j.1600-6143.2010.03055.x  PMID:20420652 
  38. Lung transplantation for cystic fibrosis. Proc Am Thorac Soc. 2009;6(8):619-33. doi:10.1513/pats.2009008-088TL  PMCID:PMC2797068  PMID:20008865 
  39. Aquagenic wrinkling of the palms in cystic fibrosis: comparison with controls and genotype-phenotype correlations. Arch Dermatol. 2009;145(11):1296-9. doi:10.1001/archdermatol.2009.260  PMID:19917960 
  40. Update on pediatric lung allocation in the United States. Pediatr Transplant. 2009;13(7):808-13. doi:10.1111/j.1399-3046.2009.01237.x  PMID:19832794 
  41. Dismal lung transplant outcomes in children with tetralogy of Fallot with pulmonary atresia compared to Eisenmenger syndrome or pulmonary vein stenosis. J Heart Lung Transplant. 2009;28(11):1221-5. doi:10.1016/j.healun.2009.07.010  PMID:19783168 
  42. Cytomegalovirus immunoglobulin decreases the risk of cytomegalovirus infection but not disease after pediatric lung transplantation. J Heart Lung Transplant. 2009;28(10):1050-6. doi:10.1016/j.healun.2009.04.032  PMCID:PMC2771443  PMID:19782286 
  43. Respiratory viral infections within one year after pediatric lung transplant. Transpl Infect Dis. 2009;11(4):304-12. doi:10.1111/j.1399-3062.2009.00397.x  PMID:19422670 
  44. The risk, prevention, and outcome of cytomegalovirus after pediatric lung transplantation. Transplantation. 2009;87(10):1541-8. doi:10.1097/TP.0b013e3181a492e8  PMCID:PMC2726779  PMID:19461492 
  45. Lung transplantation in infants and toddlers from 1990 to 2004 at St. Louis Children's Hospital. Am J Transplant. 2009;9(4):719-26. doi:10.1111/j.1600-6143.2009.02552.x  PMID:19344463 
  46. Lung transplantation in the United States, 1998-2007. Am J Transplant. 2009;9(4 Pt 2):942-58. doi:10.1111/j.1600-6143.2009.02569.x  PMID:19341417 
  47. Pediatric lung transplantation. Proc Am Thorac Soc. 2009;6(1):122-7. doi:10.1513/pats.200808-095GO  PMID:19131537 
  48. Preventable death: children on the transplant waiting list. Am J Transplant. 2008;8(12):2491-5. doi:10.1111/j.1600-6143.2008.02443.x  PMID:18976303 
  49. Selection of cystic fibrosis patients for lung transplantation. Curr Opin Pulm Med. 2008;14(6):589-94. doi:10.1097/MCP.0b013e328313e3d4  PMID:18812837 
  50. Increased mortality after pulmonary fungal infection within the first year after pediatric lung transplantation. J Heart Lung Transplant. 2008;27(6):655-61. doi:10.1016/j.healun.2008.03.010  PMCID:PMC2447528  PMID:18503966 
  51. Lung transplantation and survival in children with cystic fibrosis. N Engl J Med. 2008;358(16):1754; author reply 1755. PMID:18426004 
  52. A national conference to determine research priorities in pediatric solid organ transplantation. Pediatr Transplant. 2008;12(2):153-66. PMID:18345550 
  53. Therapeutic idiosyncrasy. Pediatr Transplant. 2008;12(2):121-2. doi:10.1111/j.1399-3046.2007.00866.x  PMID:18086249 
  54. Lung transplantation and survival in children with cystic fibrosis: solid statistics--flawed interpretation. Pediatr Transplant. 2008;12(2):129-36. doi:10.1111/j.1399-3046.2008.00924.x  PMID:18307660 
  55. Lower incidence of bronchiolitis obliterans in pediatric liver-lung transplant recipients with cystic fibrosis. Transplantation. 2007;83(11):1435-9. doi:10.1097/01.tp.0000266067.44499.07  PMID:17565316 
  56. Safety and efficacy of prolonged cytomegalovirus prophylaxis with intravenous ganciclovir in pediatric and young adult lung transplant recipients. Pediatr Transplant. 2007;11(3):312-8. doi:10.1111/j.1399-3046.2006.00626.x  PMCID:PMC1930168  PMID:17430489 
  57. Pre-transplant mechanical ventilation increases short-term morbidity and mortality in pediatric patients with cystic fibrosis. J Heart Lung Transplant. 2007;26(2):127-31. doi:10.1016/j.healun.2006.11.597  PMID:17258145 
  58. American Society of Transplantation executive summary on pediatric lung transplantation. Am J Transplant. 2007;7(2):285-92. doi:10.1111/j.1600-6143.2006.01612.x  PMID:17109726 
  59. Model for end-stage liver disease (MELD) exception for cystic fibrosis. Liver Transpl. 2006;12(12 Suppl 3):S98-9. doi:10.1002/lt.20967  PMID:17123272 
  60. Pediatric living donor lobar lung transplantation. Pediatr Transplant. 2006;10(7):861-8. doi:10.1111/j.1399-3046.2006.00559.x  PMID:17032437 
  61. Long-term outcomes after infant lung transplantation for surfactant protein B deficiency related to other causes of respiratory failure. J Pediatr. 2006;149(4):548-53. doi:10.1016/j.jpeds.2006.06.004  PMID:17011330 
  62. Preferred methods of excess hair removal in pediatric patients with lung transplantation. J Am Acad Dermatol. 2006;55(2):320-3. doi:10.1016/j.jaad.2006.03.031  PMID:16844521 
  63. Living donor lobar grafts improve pediatric lung retransplantation survival. J Thorac Cardiovasc Surg. 2006;131(5):1142-7. doi:10.1016/j.jtcvs.2005.08.074  PMID:16678602 
  64. Otolaryngological manifestations of posttransplant lymphoproliferative disorder in pediatric thoracic transplant patients. Int J Pediatr Otorhinolaryngol. 2006;70(2):303-10. doi:10.1016/j.ijporl.2005.07.011  PMID:16125255 
  65. Not so fast--don't deprive children with cystic fibrosis of the option for lung transplantation. Am J Respir Crit Care Med. 2006;173(2):246-7; author reply 247-8. doi:10.1164/ajrccm.173.2.246a  PMID:16391305 
  66. Bronchial airway anastomotic complications after pediatric lung transplantation: incidence, cause, management, and outcome. J Thorac Cardiovasc Surg. 2006;131(1):198-203. doi:10.1016/j.jtcvs.2005.06.053  PMID:16399312 
  67. Development of the new lung allocation system in the United States. Am J Transplant. 2006;6(5 Pt 2):1212-27. doi:10.1111/j.1600-6143.2006.01276.x  PMID:16613597 
  68. Pediatric transplantation in the United States, 1995-2004. Am J Transplant. 2006;6(5 Pt 2):1132-52. doi:10.1111/j.1600-6143.2006.01271.x  PMID:16613592 
  69. Role of open lung biopsy in lung transplant recipients in a single children's hospital: a 13-year experience. J Thorac Cardiovasc Surg. 2006;131(1):204-8. doi:10.1016/j.jtcvs.2005.07.059  PMID:16399313 
  70. Progressive chronic kidney disease after pediatric lung transplantation. Am J Transplant. 2005;5(7):1739-47. doi:10.1111/j.1600-6143.2005.00930.x  PMID:15943634 
  71. Sinonasal posttransplant lymphoproliferative disorder in pediatric lung transplant patients. Otolaryngol Head Neck Surg. 2005;133(1):38-41. doi:10.1016/j.otohns.2005.03.064  PMID:16025050 
  72. Primary graft dysfunction and other selected complications of lung transplantation: A single-center experience of 983 patients. J Thorac Cardiovasc Surg. 2005;129(6):1421-9. doi:10.1016/j.jtcvs.2005.01.022  PMID:15942587 
  73. Epidemiology of bloodstream infections in the first year after pediatric lung transplantation. Pediatr Infect Dis J. 2005;24(4):324-30. PMID:15818292 
  74. Pediatric transplantation, 1994-2003. Am J Transplant. 2005;5(4 Pt 2):887-903. doi:10.1111/j.1600-6135.2005.00834.x  PMID:15760416 
  75. Repair of congenital heart lesions combined with lung transplantation for the treatment of severe pulmonary hypertension: a 13-year experience. J Thorac Cardiovasc Surg. 2005;129(3):661-9. doi:10.1016/j.jtcvs.2004.07.058  PMID:15746752 
  76. Variability in standard care for cytomegalovirus prevention and detection in pediatric lung transplantation: survey of eight pediatric lung transplant programs. Pediatr Transplant. 2003;7(6):469-73. PMID:14870896 
  77. CT of posttransplantation lymphoproliferative disorder in pediatric recipients of lung allograft. AJR Am J Roentgenol. 2003;181(4):1125-31. doi:10.2214/ajr.181.4.1811125  PMID:14500243 
  78. Bilateral lung transplantation for pulmonary hypoplasia caused by congenital diaphragmatic hernia. J Thorac Cardiovasc Surg. 2003;126(1):295-7. PMID:12878973 
  79. Cytomegalovirus viremia associated with death or retransplantation in pediatric lung-transplant recipients. Transplantation. 2003;75(9):1538-43. doi:10.1097/01.TP.0000061607.07985.BD  PMID:12792511 
  80. Lung transplantation in children following treatment for malignancy. J Heart Lung Transplant. 2003;22(2):154-60. PMID:12581763 
  81. Concomitant allorecognition of mismatched donor HLA class I- and class II-derived peptides in pediatric lung transplant recipients with bronchiolitis obliterans syndrome. J Heart Lung Transplant. 2003;22(1):35-43. PMID:12531411 
  82. Lung transplantation in children. Ann Surg. 2002;236(3):270-6. doi:10.1097/01.SLA.0000027173.38874.31  PMCID:PMC1422580  PMID:12192313 
  83. Rejection is reduced in thoracic organ recipients when transplanted in the first year of life. J Heart Lung Transplant. 2002;21(3):311-8. PMID:11897518 
  84. Lung transplantation for pulmonary vascular disease. Ann Thorac Surg. 2002;73(1):209-17; discussion 217-9. PMID:11834012 
  85. Post-lung transplantation bronchiolitis obliterans syndrome: usefulness of expiratory thin-section CT for diagnosis. Radiology. 2001;220(2):455-62. doi:10.1148/radiology.220.2.r01au19455  PMID:11477251 
  86. Pediatric lung transplantation and CMV pneumonitis: a ten year experience. J Heart Lung Transplant. 2001;20(2):221. PMID:11250411 
  87. Pediatric living donor lung transplantation: psychosocial considerations. J Heart Lung Transplant. 2001;20(2):245. PMID:11250481 
  88. Lung transplantation in children following treatment for mallignancy. J Heart Lung Transplant. 2001;20(2):221. PMID:11250412 
  89. Interleukin-2-receptor blockade with daclizumab decreases the incidence of acute rejection in pediatric lung transplant recipients. J Heart Lung Transplant. 2001;20(2):221-222. PMID:11250413 
  90. Posttransplant lymphoproliferative disease in children: correlation of histology to clinical behavior. J Pediatr Hematol Oncol. 2001;23(1):14-8. PMID:11196263 
  91. High incidence of posttransplant lymphoproliferative disease in pediatric patients with cystic fibrosis. Am J Respir Crit Care Med. 2000;161(4 Pt 1):1252-5. doi:10.1164/ajrccm.161.4.9901013  PMID:10764320 
  92. Lung transplantation in very young infants. J Thorac Cardiovasc Surg. 1999;118(5):796-804. PMID:10534684 
  93. Lung retransplantation in children. Ann Thorac Surg. 1998;66(1):199-203; discussion 203-4. PMID:9692464 
  94. Pediatric and adult lung transplantation for cystic fibrosis. J Thorac Cardiovasc Surg. 1998;115(2):404-13; discussion 413-4. doi:10.1016/S0022-5223(98)70285-5  PMID:9475536 
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