Stuart C. Sweet, M.D., Ph.D.  scsweet@wustl.edu

W. McKim Marriott Professor of Pediatrics, Division of Allergy, Immunology and Pulmonary Medicine
Medical Director, Pediatric Lung Transplant Program, Division of Allergy, Immunology, and Pulmonary Medicine
Patient Oriented Research UnitAllergy, Immunology and Pulmonary Medicine

phone: (314) 454-2694

Clinical Interests

Dr. Sweet received his undergraduate, graduate and medical degrees at the University of Michigan. He was pediatric resident and pediatric pulmonology fellow at Washington University before joining the faculty in 1996. Dr. Sweet became medical director of the Pediatric Lung Transplant Program in 1999. He is board certified in Pediatric Pulmonology by the American Board of Pediatrics. Past honors include the Parker B. Francis Fellowship in Pulmonary Research, Scholar of the Child Health Research Center of Excellence in Developmental Biology, Washington University, Medical Scientist Award for Excellence, University of Michigan. Professional Societies include the International Society for Heart and Lung Transplantation, the American Thoracic Society and the American Academy of Pediatrics. Dr. Sweet's primary research is focused on improved understanding of the important factors determining outcome after lung transplantation in children. He is PI of an NIH funded multicenter collaborative study of the role B-cell immunity plays in lung transplant outcomes.Dr. Sweet has been Chair of the Organ Transplantation and Procurement Network (OPTN) / United Network for Organ Sharing (UNOS) Pediatric Transplantation Committee and Policy Oversight Committee and Secretary of the Board of Directors of the OPTN/UNOS, He is currently Secretary/Treasurer of the International Society for Heart and Lung Transplantation and Immediate Past President of the Missouri Chapter of the American Academy of Pediatrics. Dr. Sweet's other interests include ethics and policies related to organ allocation and the use of information technology in medicine.

Education

  • BS, University of Michigan College of Literature, Science and Arts1981
  • PhD, University of Michigan Horace H. Rackham School of Graduate Studies1989
  • MD, University of Michigan Medical School1990

Training

  • Research Fellow, University of Michigan Medical School1989 - 1990
  • House Officer, University of Michigan Medical School 1990 - 1990
  • Pediatric Resident, St. Louis Children's Hospital1990 - 1993
  • Pediatric Pulmonology Fellow, St. Louis Children's Hospital, Washington University School of Medicine1993 - 1996

Licensure and Board Certification

  • American Board of Pediatrics (recertified 2000, expired 2007) 1993
  • MO, 1995
  • American Board of Pediatrics, Sub Board of Pediatric Pulmonology (recertified 2005) 1998

Honors

  • Freshman Chemistry Achievement Award, University of Michigan1978
  • William J. Branstrom Freshman Prize, University of Michigan1978
  • James B. Angell Scholar, University of Michigan1979 - 1980
  • Class Honors, University of Michigan1979 - 1981
  • Phi Beta Kappa1980
  • B.S. (chemistry) with highest distinction, highest honors in chemistry and high honors in physics, University of Michigan1981
  • Roger B. Vanko Memorial Award for outstanding honors chemistry major, University of Michigan1981
  • Society of Nuclear Medicine student fellowship1982
  • Fellow, Medical Scientist Training Program, University of Michigan1982 - 1989
  • Burton L. Baker Cancer Research Fellowship, Michigan Cancer Institute1986 - 1987
  • M.D. with distinction in research, University of Michigan1989
  • Medical Scientist Award for Excellence, University of Michigan1990
  • Scholar of the Child Health Research Center of Excellence in Developmental Biology, Washington University1996 - 1997
  • Parker B. Francis Fellowship in Pulmonary Research1996 - 1997

Recent Publications view all (90)


  1. Antibody-mediated rejection of the lung: A consensus report of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2016;35(4):397-406. PMID:27044531 
  2. Recommendations for utilization of the paracorporeal lung assist device in neonates and young children with pulmonary hypertension. Pediatr Transplant. 2016;20(2):256-70. doi:10.1111/petr.12673  PMID:26899454 
  3. Perceived barriers to medication adherence in pediatric and adolescent solid organ transplantation. Pediatr Transplant. 2015. doi:10.1111/petr.12648  PMID:26670870 
  4. Lung Transplantation in Cystic Fibrosis: Trends and Controversies. Pediatr Allergy Immunol Pulmonol. 2015;28(4):237-243. doi:10.1089/ped.2015.0564  PMCID:PMC4685492  PMID:26697265 
  5. Current State of Pediatric Lung Transplantation. Lung. 2015;193(5):629-37. doi:10.1007/s00408-015-9765-z  PMID:26238859 
  6. The International Society for Heart and Lung Transplantation Registries in the Era of Big Data With Global Reach. J Heart Lung Transplant. 2015;34(10):1225-32. doi:10.1016/j.healun.2015.08.001  PMID:26454736 
  7. Electronic Cigarette Use in Middle and High School Students Triples from 2013 to 2014. Am J Respir Crit Care Med. 2015;192(3):276-8. doi:10.1164/rccm.201505-0898ED  PMID:26230233 
  8. Pediatric Deceased Donation-A Report of the Transplantation Society Meeting in Geneva. Transplantation. 2015. doi:10.1097/TP.0000000000000758  PMID:25996634 
  9. Bronchiolitis obliterans syndrome is not specific for bronchiolitis obliterans in pediatric lung transplant. J Heart Lung Transplant. 2015;34(4):516-21. doi:10.1016/j.healun.2014.10.004  PMID:25499141 
  10. Multicenter comparison of laboratory performance in cytomegalovirus and Epstein-Barr virus viral load testing using international standards. Clin Transplant. 2014;28(12):1416-23. doi:10.1111/ctr.12473  PMID:25303316 
  11. Paracorporeal lung assist devices as a bridge to recovery or lung transplantation in neonates and young children. J Thorac Cardiovasc Surg. 2014;147(1):420-6. doi:10.1016/j.jtcvs.2013.08.078  PMID:24199759 
  12. Rationing lung transplants. N Engl J Med. 2013;369(21):2064-5. doi:10.1056/NEJMc1311946#SA1  PMID:24256395 
  13. Measurement of donor-specific HLA antibodies following plasma exchange therapy predicts clinical outcome in pediatric heart and lung transplant recipients with antibody-mediated rejection. J Clin Apher. 2013;28(4):301-8. doi:10.1002/jca.21270  PMID:23426730 
  14. Induction therapy in lung transplantation. Transpl Int. 2013;26(7):696-703. doi:10.1111/tri.12115  PMID:23701023 
  15. Lung transplant is a viable treatment option for patients with congenital and acquired pulmonary vein stenosis. J Heart Lung Transplant. 2013;32(6):621-5. doi:10.1016/j.healun.2013.03.002  PMID:23701851 
  16. Neonatal paracorporeal lung assist device for respiratory failure. Ann Thorac Surg. 2013;95(2):692-4. doi:10.1016/j.athoracsur.2012.05.128  PMID:23336880 
  17. Body mass index and its effect on outcome in children after lung transplantation. J Heart Lung Transplant. 2013;32(2):196-201. doi:10.1016/j.healun.2012.11.002  PMID:23200225 
  18. Human polyomaviruses in children undergoing transplantation, United States, 2008-2010. Emerg Infect Dis. 2012;18(10):1676-9. doi:10.3201/eid1810.120359  PMCID:PMC3471627  PMID:23017293 
  19. RSV prevention and treatment in pediatric lung transplant patients: a survey of current practices among the International Pediatric Lung Transplant Collaborative. Pediatr Transplant. 2012;16(6):638-44. doi:10.1111/j.1399-3046.2012.01744.x  PMID:22738242 
  20. Report of a consensus conference on transplant program quality and surveillance. Am J Transplant. 2012;12(8):1988-96. doi:10.1111/j.1600-6143.2012.04130.x  PMID:22682114 
  21. Lung transplantation in children with idiopathic pulmonary arterial hypertension: an 18-year experience. J Heart Lung Transplant. 2011;30(10):1148-52. doi:10.1016/j.healun.2011.04.009  PMID:21620736 
  22. First experience with a paracorporeal artificial lung in a small child with pulmonary hypertension. J Thorac Cardiovasc Surg. 2011;141(6):e48-50. doi:10.1016/j.jtcvs.2011.02.005  PMID:21420104 
  23. Extracorporeal membrane oxygenation in pediatric lung transplantation. J Thorac Cardiovasc Surg. 2010;140(2):427-32. doi:10.1016/j.jtcvs.2010.04.012  PMID:20538306 
  24. Minimal acute rejection in pediatric lung transplantation--does it matter? Pediatr Transplant. 2010;14(4):534-9. doi:10.1111/j.1399-3046.2009.01268.x  PMCID:PMC2888626  PMID:20059725 
  25. Lung transplantation in the United States, 1999-2008. Am J Transplant. 2010;10(4 Pt 2):1047-68. doi:10.1111/j.1600-6143.2010.03055.x  PMID:20420652 
  26. Lung transplantation for cystic fibrosis. Proc Am Thorac Soc. 2009;6(8):619-33. doi:10.1513/pats.2009008-088TL  PMCID:PMC2797068  PMID:20008865 
  27. Aquagenic wrinkling of the palms in cystic fibrosis: comparison with controls and genotype-phenotype correlations. Arch Dermatol. 2009;145(11):1296-9. doi:10.1001/archdermatol.2009.260  PMID:19917960 
  28. Update on pediatric lung allocation in the United States. Pediatr Transplant. 2009;13(7):808-13. doi:10.1111/j.1399-3046.2009.01237.x  PMID:19832794 
  29. Dismal lung transplant outcomes in children with tetralogy of Fallot with pulmonary atresia compared to Eisenmenger syndrome or pulmonary vein stenosis. J Heart Lung Transplant. 2009;28(11):1221-5. doi:10.1016/j.healun.2009.07.010  PMID:19783168 
  30. Cytomegalovirus immunoglobulin decreases the risk of cytomegalovirus infection but not disease after pediatric lung transplantation. J Heart Lung Transplant. 2009;28(10):1050-6. doi:10.1016/j.healun.2009.04.032  PMCID:PMC2771443  PMID:19782286 
  31. Respiratory viral infections within one year after pediatric lung transplant. Transpl Infect Dis. 2009;11(4):304-12. doi:10.1111/j.1399-3062.2009.00397.x  PMID:19422670 
  32. The risk, prevention, and outcome of cytomegalovirus after pediatric lung transplantation. Transplantation. 2009;87(10):1541-8. doi:10.1097/TP.0b013e3181a492e8  PMCID:PMC2726779  PMID:19461492 
  33. Lung transplantation in infants and toddlers from 1990 to 2004 at St. Louis Children's Hospital. Am J Transplant. 2009;9(4):719-26. doi:10.1111/j.1600-6143.2009.02552.x  PMID:19344463 
  34. Lung transplantation in the United States, 1998-2007. Am J Transplant. 2009;9(4 Pt 2):942-58. doi:10.1111/j.1600-6143.2009.02569.x  PMID:19341417 
  35. Pediatric lung transplantation. Proc Am Thorac Soc. 2009;6(1):122-7. doi:10.1513/pats.200808-095GO  PMID:19131537 
  36. Preventable death: children on the transplant waiting list. Am J Transplant. 2008;8(12):2491-5. doi:10.1111/j.1600-6143.2008.02443.x  PMID:18976303 
  37. Selection of cystic fibrosis patients for lung transplantation. Curr Opin Pulm Med. 2008;14(6):589-94. doi:10.1097/MCP.0b013e328313e3d4  PMID:18812837 
  38. Increased mortality after pulmonary fungal infection within the first year after pediatric lung transplantation. J Heart Lung Transplant. 2008;27(6):655-61. doi:10.1016/j.healun.2008.03.010  PMCID:PMC2447528  PMID:18503966 
  39. Lung transplantation and survival in children with cystic fibrosis. N Engl J Med. 2008;358(16):1754; author reply 1755. PMID:18426004 
  40. A national conference to determine research priorities in pediatric solid organ transplantation. Pediatr Transplant. 2008;12(2):153-66. PMID:18345550 
  41. Therapeutic idiosyncrasy. Pediatr Transplant. 2008;12(2):121-2. doi:10.1111/j.1399-3046.2007.00866.x  PMID:18086249 
  42. Lung transplantation and survival in children with cystic fibrosis: solid statistics--flawed interpretation. Pediatr Transplant. 2008;12(2):129-36. doi:10.1111/j.1399-3046.2008.00924.x  PMID:18307660 
  43. Lower incidence of bronchiolitis obliterans in pediatric liver-lung transplant recipients with cystic fibrosis. Transplantation. 2007;83(11):1435-9. doi:10.1097/01.tp.0000266067.44499.07  PMID:17565316 
  44. Safety and efficacy of prolonged cytomegalovirus prophylaxis with intravenous ganciclovir in pediatric and young adult lung transplant recipients. Pediatr Transplant. 2007;11(3):312-8. doi:10.1111/j.1399-3046.2006.00626.x  PMCID:PMC1930168  PMID:17430489 
  45. Pre-transplant mechanical ventilation increases short-term morbidity and mortality in pediatric patients with cystic fibrosis. J Heart Lung Transplant. 2007;26(2):127-31. doi:10.1016/j.healun.2006.11.597  PMID:17258145 
  46. American Society of Transplantation executive summary on pediatric lung transplantation. Am J Transplant. 2007;7(2):285-92. doi:10.1111/j.1600-6143.2006.01612.x  PMID:17109726 
  47. Model for end-stage liver disease (MELD) exception for cystic fibrosis. Liver Transpl. 2006;12(12 Suppl 3):S98-9. doi:10.1002/lt.20967  PMID:17123272 
  48. Pediatric living donor lobar lung transplantation. Pediatr Transplant. 2006;10(7):861-8. doi:10.1111/j.1399-3046.2006.00559.x  PMID:17032437 
  49. Long-term outcomes after infant lung transplantation for surfactant protein B deficiency related to other causes of respiratory failure. J Pediatr. 2006;149(4):548-53. doi:10.1016/j.jpeds.2006.06.004  PMID:17011330 
  50. Preferred methods of excess hair removal in pediatric patients with lung transplantation. J Am Acad Dermatol. 2006;55(2):320-3. doi:10.1016/j.jaad.2006.03.031  PMID:16844521 
  51. Living donor lobar grafts improve pediatric lung retransplantation survival. J Thorac Cardiovasc Surg. 2006;131(5):1142-7. doi:10.1016/j.jtcvs.2005.08.074  PMID:16678602 
  52. Otolaryngological manifestations of posttransplant lymphoproliferative disorder in pediatric thoracic transplant patients. Int J Pediatr Otorhinolaryngol. 2006;70(2):303-10. doi:10.1016/j.ijporl.2005.07.011  PMID:16125255 
  53. Not so fast--don't deprive children with cystic fibrosis of the option for lung transplantation. Am J Respir Crit Care Med. 2006;173(2):246-7; author reply 247-8. doi:10.1164/ajrccm.173.2.246a  PMID:16391305 
  54. Bronchial airway anastomotic complications after pediatric lung transplantation: incidence, cause, management, and outcome. J Thorac Cardiovasc Surg. 2006;131(1):198-203. doi:10.1016/j.jtcvs.2005.06.053  PMID:16399312 
  55. Development of the new lung allocation system in the United States. Am J Transplant. 2006;6(5 Pt 2):1212-27. doi:10.1111/j.1600-6143.2006.01276.x  PMID:16613597 
  56. Pediatric transplantation in the United States, 1995-2004. Am J Transplant. 2006;6(5 Pt 2):1132-52. doi:10.1111/j.1600-6143.2006.01271.x  PMID:16613592 
  57. Role of open lung biopsy in lung transplant recipients in a single children's hospital: a 13-year experience. J Thorac Cardiovasc Surg. 2006;131(1):204-8. doi:10.1016/j.jtcvs.2005.07.059  PMID:16399313 
  58. Progressive chronic kidney disease after pediatric lung transplantation. Am J Transplant. 2005;5(7):1739-47. doi:10.1111/j.1600-6143.2005.00930.x  PMID:15943634 
  59. Sinonasal posttransplant lymphoproliferative disorder in pediatric lung transplant patients. Otolaryngol Head Neck Surg. 2005;133(1):38-41. doi:10.1016/j.otohns.2005.03.064  PMID:16025050 
  60. Primary graft dysfunction and other selected complications of lung transplantation: A single-center experience of 983 patients. J Thorac Cardiovasc Surg. 2005;129(6):1421-9. doi:10.1016/j.jtcvs.2005.01.022  PMID:15942587 
  61. Epidemiology of bloodstream infections in the first year after pediatric lung transplantation. Pediatr Infect Dis J. 2005;24(4):324-30. PMID:15818292 
  62. Pediatric transplantation, 1994-2003. Am J Transplant. 2005;5(4 Pt 2):887-903. doi:10.1111/j.1600-6135.2005.00834.x  PMID:15760416 
  63. Repair of congenital heart lesions combined with lung transplantation for the treatment of severe pulmonary hypertension: a 13-year experience. J Thorac Cardiovasc Surg. 2005;129(3):661-9. doi:10.1016/j.jtcvs.2004.07.058  PMID:15746752 
  64. Variability in standard care for cytomegalovirus prevention and detection in pediatric lung transplantation: survey of eight pediatric lung transplant programs. Pediatr Transplant. 2003;7(6):469-73. PMID:14870896 
  65. CT of posttransplantation lymphoproliferative disorder in pediatric recipients of lung allograft. AJR Am J Roentgenol. 2003;181(4):1125-31. doi:10.2214/ajr.181.4.1811125  PMID:14500243 
  66. Bilateral lung transplantation for pulmonary hypoplasia caused by congenital diaphragmatic hernia. J Thorac Cardiovasc Surg. 2003;126(1):295-7. PMID:12878973 
  67. Cytomegalovirus viremia associated with death or retransplantation in pediatric lung-transplant recipients. Transplantation. 2003;75(9):1538-43. doi:10.1097/01.TP.0000061607.07985.BD  PMID:12792511 
  68. Lung transplantation in children following treatment for malignancy. J Heart Lung Transplant. 2003;22(2):154-60. PMID:12581763 
  69. Concomitant allorecognition of mismatched donor HLA class I- and class II-derived peptides in pediatric lung transplant recipients with bronchiolitis obliterans syndrome. J Heart Lung Transplant. 2003;22(1):35-43. PMID:12531411 
  70. Lung transplantation in children. Ann Surg. 2002;236(3):270-6. doi:10.1097/01.SLA.0000027173.38874.31  PMCID:PMC1422580  PMID:12192313 
  71. Rejection is reduced in thoracic organ recipients when transplanted in the first year of life. J Heart Lung Transplant. 2002;21(3):311-8. PMID:11897518 
  72. Lung transplantation for pulmonary vascular disease. Ann Thorac Surg. 2002;73(1):209-17; discussion 217-9. PMID:11834012 
  73. Post-lung transplantation bronchiolitis obliterans syndrome: usefulness of expiratory thin-section CT for diagnosis. Radiology. 2001;220(2):455-62. doi:10.1148/radiology.220.2.r01au19455  PMID:11477251 
  74. Pediatric lung transplantation and CMV pneumonitis: a ten year experience. J Heart Lung Transplant. 2001;20(2):221. PMID:11250411 
  75. Pediatric living donor lung transplantation: psychosocial considerations. J Heart Lung Transplant. 2001;20(2):245. PMID:11250481 
  76. Lung transplantation in children following treatment for mallignancy. J Heart Lung Transplant. 2001;20(2):221. PMID:11250412 
  77. Interleukin-2-receptor blockade with daclizumab decreases the incidence of acute rejection in pediatric lung transplant recipients. J Heart Lung Transplant. 2001;20(2):221-222. PMID:11250413 
  78. Posttransplant lymphoproliferative disease in children: correlation of histology to clinical behavior. J Pediatr Hematol Oncol. 2001;23(1):14-8. PMID:11196263 
  79. High incidence of posttransplant lymphoproliferative disease in pediatric patients with cystic fibrosis. Am J Respir Crit Care Med. 2000;161(4 Pt 1):1252-5. doi:10.1164/ajrccm.161.4.9901013  PMID:10764320 
  80. Lung transplantation in very young infants. J Thorac Cardiovasc Surg. 1999;118(5):796-804. PMID:10534684 
  81. Lung retransplantation in children. Ann Thorac Surg. 1998;66(1):199-203; discussion 203-4. PMID:9692464 
  82. Pediatric and adult lung transplantation for cystic fibrosis. J Thorac Cardiovasc Surg. 1998;115(2):404-13; discussion 413-4. doi:10.1016/S0022-5223(98)70285-5  PMID:9475536 
  83. Pediatric lung transplantation at St. Louis Children's Hospital, 1990-1995. Am J Respir Crit Care Med. 1997;155(3):1027-35. doi:10.1164/ajrccm.155.3.9116982  PMID:9116982 
  84. Lung transplantation in children and young adults with cardiovascular disease. Ann Thorac Surg. 1995;59(4):813-20; discussion 820-1. PMID:7695402 
  85. Presence of matrix-specific antibodies in affinity-purified polyclonal antibodies. J Immunol Methods. 1991;136(1):31-6. PMID:1995710 
  86. Calmodulin is associated with microtubules forming in PTK1 cells upon release from nocodazole treatment. Cell Motil Cytoskeleton. 1989;12(2):113-22. doi:10.1002/cm.970120206  PMID:2713899 
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  88. Calmodulin colocalization with cold-stable and nocodazole-stable microtubules in living PtK1 cells. Eur J Cell Biol. 1988;47(1):88-93. PMID:3068060 
  89. Dynamics of a fluorescent calmodulin analog in the mammalian mitotic spindle at metaphase. Cell Motil Cytoskeleton. 1988;9(3):231-42. doi:10.1002/cm.970090305  PMID:2896549 
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