Department of Pediatrics

Clinical Interests

Dr. Wilson is a physician-scientist in the Division of Pediatric Hematology-Oncology. Areas of clinical interest include bone marrow failure, hemolytic anemias, coagulation disorders, and cancer predisposition syndromes. His basic research laboratory studies the role of transcription factors in development and oncogenesis.

Education

• BA, Kalamazoo College, 1980
• MD, Washington University School of Medicine, 1986
• PhD, Washington University School of Medicine, 1986

Training

• Pediatric Resident, Boston Children's Hospital, 1986 - 1988
• Hematology/Oncology Fellow, Dana Farber Cancer Inst, 1988 - 1991

Licensure and Board Certification

• 1993 - PresMO, Physician
• 1993 - 2008Pediatrics
• 1996 - PresPediatric Hematology/Oncology
• 2015 - 2017IL, Physician

Honors and Awards

• Honors in Chemistry, Kalamazoo College, 1980
• Phi Beta Kappa, 1980
• Carter Prize for Achievement in the Medical Curriculum, 1981
• Lowry Prize in Pharmacology, 1982
• Alpha Omega Alpha, 1986
• McDonnell Scholars Award in Oncology, 1992
• Pfizer Junior Faculty Award in Cardiovascular Biology, 1992
• March of Dimes Basil O'Connor Award, 1993
• American Heart Association Established Investigator Award, 1995
• American Society for Clinical Investigation, 1998
• Robert Strunk MD Award in Clinical Excellence for outstanding contributions to the outpatient clinical services, 2018

Recent Publications view all (115)

Publication Co-Authors

Megan A. Cooper, M.D., Ph.D.

Shalini Shenoy, M.D.

Stuart C. Sweet, M.D., Ph.D.

Marwan Shinawi, M.D.

Mary C. Dinauer, M.D., Ph.D.

Laura Schuettpelz, M.D, Ph.D.

David A. Rudnick, M.D., Ph.D.

Thomas Ferkol, M.D.

Rachel Slaugh, MS, CGC

Maleewan Kitcharoensakkul, MD, MSCI

Monica Hulbert, M.D.

Rachel C. Orscheln, M.D.

Katarina Semkiu

Jorge L Granadillo, MD, MSc.

Allison King, M.D., M.P.H., Ph.D.

Cori Grant

Dorothy Katherine Grange, M.D.

Frederick S. Huang, M.D.

Robert J. Hayashi, M.D.

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with David B. Wilson, M.D., Ph.D.

1. Andersson N, Haltia U-M, Färkkilä A, Wong SC, Eloranta K, Wilson DB, Unkila-Kallio L, Pihlajoki M, Kyrönlahti A, Heikinheimo M. Analysis of non-relapsed and relapsed adult type granulosa cell tumors suggests stable transcriptomes during tumor progression. Curr Issues Mol Biol. 2022;44(2):686-698. doi:10.3390/cimb44020048  
2. Wilson DB, Hoefgen HR, Vrecenak JD. Letter to the Editor: "Uterine sarcoma auto-amputation in an infant with DICER1 syndrome". J Pediatr Adolesc Gynecol. 2021. doi:10.1016/j.jpag.2021.12.012.  PMID:34973456 
3. Bigley TM, Song Z, Orscheln RC, Wilson DB, Shakhsheer BA, He M, Sweet SC, Dinauer MC, Kitcharoensakkul M. X-linked chronic granulomatous disease presenting with mediastinal lipoblastoma and adjacent pneumonia J Clin Immunol. 2021;41(8):1969-1971. doi:10.1007/s10875-021-01129-w   PMID:34462840 
4. Towerman AS, Wilson DB, Hulbert ML. Epstein-Barr virus-induced sickle hepatopathy. Pediatr Blood Cancer. 2021;68(9):e29196. doi:10.1002/pbc.29196   PMID:34180131 
5. Eloranta K, Nousiainen R, Cairo S, Pakarinen MP, Wilson DB, Pihlajoki M, Heikinheimo M. Neuropilin-2 is associated with increased hepatoblastoma cell viability and motility. Front Pediatr. 2021;9:660482. doi:10.3389/fped.2021.660482  PMCID:PMC8257959  PMID:34239847 
6. Zhou HF, Amarillo IE, Snyder S, Granadillo JL, O'Conor CJ, Dillon P, Wilson D, Huang FS, Dehner LP, He M. Confirmation of Xp22.11 duplication as a germline susceptibility alteration in a Wilms tumor arising in horseshoe kidney. Fetal Pediatr Pathol. 2021;1-6. doi:10.1080/15513815.2021.1921892  PMID:33960268 
7. Kyrönlahti A, Godbole N, Akinrinade O, Soini T, Nyholm I, Andersson N, Hukkinen M, Lohi J, Wilson DB, Pihlajoki M, Pakarinen MP, Heikinheimo M. Evolving up-regulation of biliary fibrosis related extracellular matrix molecules after successful portoenterostomy. Hepatol Commun. 2021;2021(5):1036-1050. doi:10.1002/hep4.1684  
8. Pihlajoki M, Soini T, Cochran RB, Liljeström E, Huang J, Rudnick DA, Dietzen DJ, Kyrönlahti A, Pakarinen MP, Heikinheimo M, Wilson DB. GATA6 modulates the ductular reaction to bile duct ligation. Hepatol Int. 2021;15(1):166-178. doi:10.1007/s12072-020-10119-w  PMID:33486744 
9. Eloranta K, Cairo S, Liljeström E, Soini T, Kyrönlahti A, Judde J, Wilson DB, Heikinheimo M, Pihlajoki M. Chloroquine triggers cell death by targeting PARPs in cell models of aggressive hepatoblastoma. Front Oncol (Lausanne). 2020;10:1138. doi:10.3389/fonc.2020.01138  PMCID:PMC7379510  PMID:32766148 
10. Hall BJ, Reiter AJ, Englum BR, Rothman JA, Rice HE on behalf of the Splenectomy in Congenital Hemolytic Anemia (SICHA) Consortium. Long-term hematologic and clinical outcomes of splenectomy in children with hereditary spherocytosis and sickle cell disease. Pediatr Blood Cancer. 2020;67(8):e28290. doi:10.1002/pbc.28290  
11. Crowgey EL, Soini T, Shah N, Pauniaho SL, Lahdenne P, Wilson DB, Heikinheimo M, Druley TE. Germline sequencing identifies rare variants in Finnish subjects with familial germ cell tumors. Appl Clin Genet. 2020;13:127-137. doi:10.2147/TACG.S245093  PMCID:PMC7335280  PMID:32636668 
12. Haltia UM, Pihlajoki M, Andersson N, Mäkinen L, Tapper J, Cervera A, Horlings HM, Turpeinen U, Anttonen M, Bützow R, Unkila-Kallio L, Carpén O, Wilson DB, Heikinheimo M, Färkkilä A. Functional profiling of FSH and estradiol in ovarian granulosa cell tumors. J Endocr Soc. 2020;4(4):bvaa034. doi:10.1210/jendso/bvaa034  PMCID:PMC7153750  PMID:32309755 
13. Semkiu KM, Oliveira JL, Nguyen PL, Porter TR, Wilson DB. Hb F-Wentzville [Gγ24(B6)Gly→Glu; HBG2: c.74G>A, p.Gly25Glu]: An unstable Gγ-globin variant associated with neonatal hemolytic anemia. Hemoglobin. 2020;1-3. doi:10.1080/03630269.2020.1716002  PMID:31985299 
14. Thompson E, Abdalla E, Superti-Furga A, McAlister W, Kratz L, Unger S, Royer-Bertrand B, Campos-Xavier B, Mittaz-Crettol L, Amin AK, DeSanto C, Wilson DB, Douglas G, Kozel B, Shinawi M. Lamin B receptor-related disorder is associated with a spectrum of skeletal dysplasia phenotypes. Bone. 2019;120:354-363. doi:10.1016/j.bone.2018.11.006  PMID:30448303 
15. Gabani P, Fischer-Valuck BW, Robinson CG, Wilson DB, Michalski JM. Stereotactic body radiation therapy for the treatment of primary cardiac angiosarcoma causing hemodynamic instability. Pract Radiat Oncol. 2019;9(1):5-8. doi:10.1016/j.prro.2018.07.004  PMID:30611463 
16. Soini T, Eloranta K, Pihlajoki M, Kyrönlahti A, Akinrinade O, Andersson N, Lohi J, Pakarinen MP, Wilson DB, Heikinheimo M. Transcription factor GATA4 associates with mesenchymal-like gene expression in human hepatoblastoma cells. Tumour Biol. 2018;40(7):1010428318785498. doi:10.1177/1010428318785498  PMID:30074440 
17. Soini T, Pihlajoki M, Andersson N, Lohi J, Huppert KA, Rudnick DA, Huppert SS, Wilson DB, Pakarinen MP, Heikinheimo M. Transcription factor GATA6: a novel marker and putative inducer of ductal metaplasia in biliary atresia. Am J Physiol Gastrointest Liver Physiol. 2018;314(5):G547-G558. doi:10.1152/ajpgi.00362.2017  PMCID:PMC6008062  PMID:29388792 
18. Xia J, Miller CA, Baty J, Ramesh A, Jotte MRM, Fulton RS, Vogel TP, Cooper MA, Walkovich KJ, Makaryan V, Bolyard AA, Dinauer MC, Wilson DB, Vlachos A, Myers KC, Rothbaum RJ, Bertuch AA, Dale DC, Shimamura A, Boxer LA, Link DC. Somatic mutations and clonal hematopoiesis in congenital neutropenia. Blood. 2018;131(4):408-416. doi:10.1182/blood-2017-08-801985  PMCID:PMC5790127  PMID:29092827 
19. Wilson DB, Bessler M, Ferkol TW, Shenoy S, Amano N, Ishii T, Shima H, Narumi S. Comment on: Acquired monosomy 7 myelodysplastic syndrome in a child with clinical features of dyskeratosis congenita and IMAGe association. Pediatr Blood Cancer. 2018;65(1). doi:10.1002/pbc.26747  PMID:28834235 
20. Penny GM, Cochran RB, Pihlajoki M, Kyrönlahti A, Schrade A, Häkkinen M, Toppari J, Heikinheimo M, Wilson DB. Probing GATA factor function in mouse Leydig cells via testicular injection of adenoviral vectors. Reproduction. 2017;154(4):455–467. doi:10.1530/REP-17-0311  PMCID:PMC5589507  PMID:28710293 
21. Panzer AA, Regmi SD, Cormier D, Danzo MT, Chen ID, Winston JB, Hutchinson AK, Salm D, Schulkey CE, Cochran RS, Wilson DB, Jay PY. Nkx2-5 and Sarcospan genetically interact in the development of the muscular ventricular septum of the heart. Sci Rep. 2017;7:46438. doi:10.1038/srep46438  PMCID:PMC5390293  PMID:28406175 
22. Soini T, Pihlajoki M, Kyrönlahti A, Andersson LC, Wilson DB, Heikinheimo M. Downregulation of transcription factor GATA4 sensitizes human hepatoblastoma cells to doxorubicin-induced apoptosis. Tumour Biol. 2017;39(3):1010428317695016. doi:10.1177/1010428317695016  PMID:28349834 
23. Dörner J, Rodriguez VM, Ziegler R, Röhrig T, Cochran RS, Götz RM, Levin MD, Pihlajoki M, Heikinheimo M, Wilson DB. GLI1+ progenitor cells in the adrenal capsule of the adult mouse give rise to heterotopic gonadal-like tissue. Mol Cell Endocrinol. 2016;441:164–175. doi:10.1016/j.mce.2016.08.043  PMCID:PMC5235954  PMID:27585489 
24. Schrade A, Kyrönlahti A, Akinrinade O, Pihlajoki M, Fischer S, Rodriguez VM, Otte K, Velagapudi V, Toppari J, Wilson DB, Heikinheimo M. GATA4 regulates blood-testis barrier function and lactate metabolism in mouse Sertoli cells. Endocrinology. 2016;157(6):2416-31. doi:10.1210/en.2015-1927  PMCID:PMC4891789  PMID:26974005 
25. Englum BR, Rothman J, Leonard S, Reiter A, Thornburg C, Brindle M, Wright N, Heeney MM, Jason Smithers C, Brown RL, Kalfa T, Langer JC, Cada M, Oldham KT, Scott JP, St Peter SD, Sharma M, Davidoff AM, Nottage K, Bernabe K, Wilson DB, Dutta S, Glader B, Crary SE, Dassinger MS, Dunbar L, Islam S, Kumar M, Rescorla F, Bruch S, Campbell A, Austin M, Sidonio R, Blakely ML, Rice HE, Splenectomy in Congenital Hemolytic Anemia Consortium. Hematologic outcomes after total splenectomy and partial splenectomy for congenital hemolytic anemia. J Pediatr Surg. 2016;51(1):122-7. doi:10.1016/j.jpedsurg.2015.10.028  PMCID:PMC5083068  PMID:26613837 
26. Schrade A, Kyrönlahti A, Akinrinade O, Pihlajoki M, Häkkinen M, Fischer S, Alastalo TP, Velagapudi V, Toppari J, Wilson DB, Heikinheimo M. GATA4 is a key regulator of steroidogenesis and glycolysis in mouse Leydig cells. Endocrinology. 2015;156(5):1860-1872. doi:10.1210/en.2014-1931  PMCID:PMC4398762  PMID:25668067 
27. Schulkey CE, Regmi SD, Magnan RA, Danzo MT, Luther H, Hutchinson AK, Panzer AA, Grady MM, Wilson DB, Jay PY. The maternal-age-associated risk of congenital heart disease is modifiable. Nature. 2015;520(7546):230-33. doi:10.1038/nature14361  PMCID:PMC4393370  PMID:25830876 
28. Rice HE, Englum BR, Rothman J, Leonard S, Reiter A, Thornburg C, Brindle M, Wright N, Heeney MM, Smithers C, Brown RL, Kalfa T, Langer JC, Cada M, Oldham KT, Scott JP, St Peter S, Sharma M, Davidoff AM, Nottage K, Bernabe K, Wilson DB, Dutta S, Glader B, Crary SE, Dassinger MS, Dunbar L, Islam S, Kumar M, Rescorla F, Bruch S, Campbell A, Austin M, Sidonio R, Blakely ML, Splenectomy in Congenital Hemolytic Anemia (SICHA) Consortium. Clinical outcomes of splenectomy in children: report of the splenectomy in congenital hemolytic anemia registry. Am J Hematol. 2015;90(3):187-92. doi:10.1002/ajh.23888  PMCID:PMC4333061  PMID:25382665 
29. Schillebeeckx M, Pihlajoki M, Gretzinger E, Yang W, Thol F, Hiller T, Löbs AK, Röhrig T, Schrade A, Cochran R, Jay PY, Heikinheimo M, Mitra RD, Wilson DB. Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret. Mol Cell Endocrinol. 2015;399:122-30. doi:10.1016/j.mce.2014.09.029  PMCID:PMC4262703  PMID:25289806 
30. Gautier EL, Ivanov S, Williams JW, Huang SC, Marcelin G, Fairfax K, Wang PL, Francis JS, Leone P, Wilson DB, Artyomov MN, Pearce EJ, Randolph GJ. Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival. J Exp Med. 2014;211(8):1525-31. doi:10.1084/jem.20140570  PMCID:PMC4113942  PMID:25024137 
31. Parviainen H, Schrade A, Kiiveri S, Prunskaite-Hyyryläinen R, Haglund C, Vainio S, Wilson DB, Arola J, Heikinheimo M. Expression of Wnt and TGF-β pathway components and key adrenal transcription factors in adrenocortical tumors: association to carcinoma aggressiveness. Pathol Res Pract. 2013;209(8):503-9. doi:10.1016/j.prp.2013.06.002  PMCID:PMC3777642  PMID:23866946 
32. Vogiatzi P, Perdigones N, Mason PJ, Wilson DB, Bessler M. A family with Hoyeraal-Hreidarsson syndrome and four variants in two genes of the telomerase core complex. Pediatr Blood Cancer. 2013;60(6):E4-6. doi:10.1002/pbc.24389  PMCID:PMC3860171  PMID:23335200 
33. Schillebeeckx M, Schrade A, Löbs AK, Pihlajoki M, Wilson DB, Mitra RD. Laser capture microdissection-reduced representation bisulfite sequencing (LCM-RRBS) maps changes in DNA methylation associated with gonadectomy-induced adrenocortical neoplasia in the mouse. Nucleic Acids Res. 2013;41(11):e116. doi:10.1093/nar/gkt230  PMCID:PMC3675465  PMID:23589626 
34. Pihlajoki M, Gretzinger E, Cochran R, Kyrönlahti A, Schrade A, Hiller T, Sullivan L, Shoykhet M, Schoeller EL, Brooks MD, Heikinheimo M, Wilson DB. Conditional mutagenesis of Gata6 in SF1-positive cells causes gonadal-like differentiation in the adrenal cortex of mice. Endocrinology. 2013;154(5):1754-67. doi:10.1210/en.2012-1892  PMCID:PMC3628026  PMID:23471215 
35. Krachulec J, Vetter M, Schrade A, Löbs AK, Bielinska M, Cochran R, Kyrönlahti A, Pihlajoki M, Parviainen H, Jay PY, Heikinheimo M, Wilson DB. GATA4 is a critical regulator of gonadectomy-induced adrenocortical tumorigenesis in mice. Endocrinology. 2012;153(6):2599-611. doi:10.1210/en.2011-2135  PMCID:PMC3359595  PMID:22461617 
36. Rice HE, Crary SE, Langer JC, Kemper AR, Splenectomy in Congenital Hemolytic Anemia Consortium. Comparative effectiveness of different types of splenectomy for children with congenital hemolytic anemias. J Pediatr. 2012;160(4):684-689.e13. doi:10.1016/j.jpeds.2011.09.030  PMID:22050869 
37. Zou J, Majerus PW, Wilson DB, Schrade A, Chang SC, Wilson MP. The role of myotubularin-related phosphatases in the control of autophagy and programmed cell death. Adv Biol Regul. 2012;52(1):282-9. doi:10.1016/j.advenzreg.2011.10.001  PMCID:PMC3565244  PMID:22056831 
38. Soini T, Haveri H, Elo JM, Kauppinen M, Kyrönlahti A, Salo MK, Lohi J, Andersson LC, Wilson DB, Heikinheimo M. Transcription factor GATA-4 is abundantly expressed in childhood but not in adult liver tumors. J Pediatr Gastroenterol Nutr. 2012;54(1):101-8. doi:10.1097/MPG.0b013e31822d52cf  PMID:21788913 
39. Kyrönlahti A, Vetter M, Euler R, Bielinska M, Jay PY, Anttonen M, Heikinheimo M, Wilson DB. GATA4 deficiency impairs ovarian function in adult mice. Biol Reprod. 2011;84(5):1033-44. doi:10.1095/biolreprod.110.086850  PMCID:PMC3080425  PMID:21248289 
40. Kyrönlahti A, Euler R, Bielinska M, Schoeller EL, Moley KH, Toppari J, Heikinheimo M, Wilson DB. GATA4 regulates Sertoli cell function and fertility in adult male mice. Mol Cell Endocrinol. 2011;333(1):85-95. doi:10.1016/j.mce.2010.12.019  PMCID:PMC3026658  PMID:21172404 
41. Kyrönlahti A, Kauppinen M, Lind E, Unkila-Kallio L, Butzow R, Klefström J, Wilson DB, Anttonen M, Heikinheimo M. GATA4 protects granulosa cell tumors from TRAIL-induced apoptosis. Endocr Relat Cancer. 2010;17(3):709-17. doi:10.1677/ERC-10-0041  PMID:20554787 
42. Majerus PW, Wilson DB, Zhang C, Nicholas PJ, Wilson MP. Expression of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) and its role in neural tube defects. Adv Enzyme Regul. 2010;50(1):365-72. doi:10.1016/j.advenzreg.2009.10.017  PMCID:PMC2862868  PMID:19914276 
43. McDonald S, Wilson DB, Pumbo E, Kulkarni S, Mason PJ, Else T, Bessler M, Ferkol T, Shenoy S. Acquired monosomy 7 myelodysplastic syndrome in a child with clinical features suggestive of dyskeratosis congenita and IMAGe association. Pediatr Blood Cancer. 2010;54(1):154-7. doi:10.1002/pbc.22283  PMID:19760774 
44. Schuettpelz LG, McDonald S, Whitesell K, Desruisseau DM, Grange DK, Gurnett CA, Wilson DB. Pilocytic astrocytoma in a child with Noonan syndrome. Pediatr Blood Cancer. 2009;53(6):1147-9. doi:10.1002/pbc.22193  PMID:19621452 
45. Kanter J, Wilson DB, Strasberg S. Downsizing to resectability of a large solid and cystic papillary tumor of the pancreas by single-agent chemotherapy. J Pediatr Surg. 2009;44(10):e23-5. doi:10.1016/j.jpedsurg.2009.07.026  PMID:19853735 
46. Haveri H, Ashorn M, Iltanen S, Wilson DB, Andersson LC, Heikinheimo M. Enhanced expression of transcription factor GATA-4 in inflammatory bowel disease and its possible regulation by TGF-beta1. J Clin Immunol. 2009;29(4):444-53. doi:10.1007/s10875-009-9292-x  PMID:19353247 
47. Wilson MP, Hugge C, Bielinska M, Nicholas P, Majerus PW, Wilson DB. Neural tube defects in mice with reduced levels of inositol 1,3,4-trisphosphate 5/6-kinase. Proc Natl Acad Sci U S A. 2009;106(24):9831-5. doi:10.1073/pnas.0904172106  PMCID:PMC2701051  PMID:19482943 
48. Du HY, Mason PJ, Bessler M, Wilson DB. TINF2 mutations in children with severe aplastic anemia. Pediatr Blood Cancer. 2009;52(5):687. doi:10.1002/pbc.21903  PMCID:PMC2860792  PMID:19090550 
49. Du HY, Pumbo E, Ivanovich J, An P, Maziarz RT, Reiss UM, Chirnomas D, Shimamura A, Vlachos A, Lipton JM, Goyal RK, Goldman F, Wilson DB, Mason PJ, Bessler M. TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements. Blood. 2009;113(2):309-16. doi:10.1182/blood-2008-07-166421  PMCID:PMC2615648  PMID:18931339 
50. Wagner S, Kiupel M, Peterson RA 2nd, Heikinheimo M, Wilson DB. Cytochrome b5 expression in gonadectomy-induced adrenocortical neoplasms of the domestic ferret (Mustela putorius furo). Vet Pathol. 2008;45(4):439-42. doi:10.1354/vp.45-4-439  PMCID:PMC2497446  PMID:18587089 
51. Rao A, Kelly M, Musselman M, Ramadas J, Wilson D, Grossman W, Shenoy S. Safety, efficacy, and immune reconstitution after rituximab therapy in pediatric patients with chronic or refractory hematologic autoimmune cytopenias. Pediatr Blood Cancer. 2008;50(4):822-5. doi:10.1002/pbc.21264  PMID:17570702 
52. Du HY, Pumbo E, Manley P, Field JJ, Bayliss SJ, Wilson DB, Mason PJ, Bessler M. Complex inheritance pattern of dyskeratosis congenita in two families with 2 different mutations in the telomerase reverse transcriptase gene. Blood. 2008;111(3):1128-30. doi:10.1182/blood-2007-10-120907  PMCID:PMC2214749  PMID:18042801 
53. Du HY, Idol R, Robledo S, Ivanovich J, An P, Londono-Vallejo A, Wilson DB, Mason PJ, Bessler M. Telomerase reverse transcriptase haploinsufficiency and telomere length in individuals with 5p- syndrome. Aging Cell. 2007;6(5):689-97. doi:10.1111/j.1474-9726.2007.00324.x  PMCID:PMC2583393  PMID:17875000 
54. Bielinska M, Jay PY, Erlich JM, Mannisto S, Urban Z, Heikinheimo M, Wilson DB. Molecular genetics of congenital diaphragmatic defects. Ann Med. 2007;39(4):261-74. doi:10.1080/07853890701326883  PMCID:PMC2174621  PMID:17558598 
55. Rao A, Hulbert M, Wilson DB. Severe hypertriglyceridemia in an infant with red cell pyruvate kinase deficiency. Indian Pediatr. 2007;44(4):303-5. PMID:17468529 
56. Jay PY, Bielinska M, Erlich JM, Mannisto S, Pu WT, Heikinheimo M, Wilson DB. Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects. Dev Biol. 2007;301(2):602-14. doi:10.1016/j.ydbio.2006.09.050  PMCID:PMC1808541  PMID:17069789 
57. Bielinska M, Seehra A, Toppari J, Heikinheimo M, Wilson DB. GATA-4 is required for sex steroidogenic cell development in the fetal mouse. Dev Dyn. 2007;236(1):203-13. doi:10.1002/dvdy.21004  PMCID:PMC2174205  PMID:17096405 
58. Idol RA, Robledo S, Du HY, Crimmins DL, Wilson DB, Ladenson JH, Bessler M, Mason PJ. Cells depleted for RPS19, a protein associated with Diamond Blackfan Anemia, show defects in 18S ribosomal RNA synthesis and small ribosomal subunit production. Blood Cells Mol Dis. 2007;39(1):35-43. doi:10.1016/j.bcmd.2007.02.001  PMID:17376718 
59. Huang Q, Robledo S, Wilson DB, Bessler M, Mason PJ. A four base pair insertion in exon 1 of the RPS19 gene is a common polymorphism in African-Americans. Br J Haematol. 2006;135(5):745-746. doi:10.1111/j.1365-2141.2006.06368.x  PMID:17107358 
60. Field JJ, Mason PJ, An P, Kasai Y, McLellan M, Jaeger S, Barnes YJ, King AA, Bessler M, Wilson DB. Low frequency of telomerase RNA mutations among children with aplastic anemia or myelodysplastic syndrome. J Pediatr Hematol Oncol. 2006;28(7):450-3. doi:10.1097/01.mph.0000212952.58597.84  PMID:16825992 
61. Anttonen M, Parviainen H, Kyrönlahti A, Bielinska M, Wilson DB, Ritvos O, Heikinheimo M. GATA-4 is a granulosa cell factor employed in inhibin-alpha activation by the TGF-beta pathway. J Mol Endocrinol. 2006;36(3):557-68. doi:10.1677/jme.1.01962  PMID:16720723 
62. Bielinska M, Kiiveri S, Parviainen H, Mannisto S, Heikinheimo M, Wilson DB. Gonadectomy-induced adrenocortical neoplasia in the domestic ferret (Mustela putorius furo) and laboratory mouse. Vet Pathol. 2006;43(2):97-117. doi:10.1354/vp.43-2-97  PMID:16537928 
63. Jacobsen CM, Mannisto S, Porter-Tinge S, Genova E, Parviainen H, Heikinheimo M, Adameyko II, Tevosian SG, Wilson DB. GATA-4:FOG interactions regulate gastric epithelial development in the mouse. Dev Dyn. 2005;234(2):355-62. doi:10.1002/dvdy.20552  PMID:16127717 
64. Bielinska M, Genova E, Boime I, Parviainen H, Kiiveri S, Leppäluoto J, Rahman N, Heikinheimo M, Wilson DB. Gonadotropin-induced adrenocortical neoplasia in NU/J nude mice. Endocrinology. 2005;146(9):3975-84. doi:10.1210/en.2004-1643  PMID:15919738 
65. Shenoy S, Grossman WJ, DiPersio J, Yu LC, Wilson D, Barnes YJ, Mohanakumar T, Rao A, Hayashi RJ. A novel reduced-intensity stem cell transplant regimen for nonmalignant disorders. Bone Marrow Transplant. 2005;35(4):345-52. doi:10.1038/sj.bmt.1704795  PMID:15592491 
66. Bielinska M, Genova E, Boime I, Parviainen H, Kiiveri S, Rahman N, Leppäluoto J, Heikinheimo M, Wilson DB. Nude mice as a model for gonadotropin-induced adrenocortical neoplasia. Endocr Res. 2004;30(4):913-7. PMID:15666844 
67. Divine JK, Staloch LJ, Haveri H, Jacobsen CM, Wilson DB, Heikinheimo M, Simon TC. GATA-4, GATA-5, and GATA-6 activate the rat liver fatty acid binding protein gene in concert with HNF-1alpha. Am J Physiol Gastrointest Liver Physiol. 2004;287(5):G1086-99. doi:10.1152/ajpgi.00421.2003  PMID:14715527 
68. Ketola I, Otonkoski T, Pulkkinen MA, Niemi H, Palgi J, Jacobsen CM, Wilson DB, Heikinheimo M. Transcription factor GATA-6 is expressed in the endocrine and GATA-4 in the exocrine pancreas. Mol Cell Endocrinol. 2004;226(1-2):51-7. doi:10.1016/j.mce.2004.06.007  PMID:15489005 
69. Rahman NA, Kiiveri S, Rivero-Müller A, Levallet J, Vierre S, Kero J, Wilson DB, Heikinheimo M, Huhtaniemi I. Adrenocortical tumorigenesis in transgenic mice expressing the inhibin alpha-subunit promoter/simian virus 40 T-antigen transgene: relationship between ectopic expression of luteinizing hormone receptor and transcription factor GATA-4. Mol Endocrinol. 2004;18(10):2553-69. doi:10.1210/me.2002-0282  PMID:15256532 
70. Peterson RA 2nd, Kiupel M, Bielinska M, Kiiveri S, Heikinheimo M, Capen CC, Wilson DB. Transcription factor GATA-4 is a marker of anaplasia in adrenocortical neoplasms of the domestic ferret (Mustela putorius furo). Vet Pathol. 2004;41(4):446-9. doi:10.1354/vp.41-4-446  PMID:15232151 
71. Wilson DB, Rao A, Hulbert M, Mychaliska KP, Luchtman-Jones L, Hill DA, Foglia RP. Neutropenic enterocolitis as a presenting complication of acute lymphoblastic leukemia: an unusual case marked by delayed perforation of the descending colon. J Pediatr Surg. 2004;39(7):e18-20. PMID:15213940 
72. Grossman WJ, Wilson DB. Hypopigmentation from imatinib mesylate (Gleevec). J Pediatr Hematol Oncol. 2004;26(3):214. PMID:15125619 
73. Wilson DB, Michalski JM, Grossman WJ, Hayashi RJ. Isolated CNS relapse following stem cell transplantation for juvenile myelomonocytic leukemia. J Pediatr Hematol Oncol. 2003;25(11):910-3. PMID:14608204 
74. Hostetler MA, Dribben W, Wilson DB, Grossman WJ. Sudden unexplained hemolysis occurring in an infant due to presumed Loxosceles envenomation. J Emerg Med. 2003;25(3):277-82. PMID:14585455 
75. Bielinska M, Parviainen H, Porter-Tinge SB, Kiiveri S, Genova E, Rahman N, Huhtaniemi IT, Muglia LJ, Heikinheimo M, Wilson DB. Mouse strain susceptibility to gonadectomy-induced adrenocortical tumor formation correlates with the expression of GATA4 and luteinizing hormone receptor. Endocrinology. 2003;144(9):4123-33. doi:10.1210/en.2003-0126  PMID:12933687 
76. Wilson DB, Ivanovich J, Whelan A, Goodfellow PJ, Bessler M. Human telomerase RNA mutations and bone marrow failure. Lancet. 2003;361(9373):1993-4. PMID:12801777 
77. Clabby ML, Robison TA, Quigley HF, Wilson DB, Kelly DP. Retinoid X receptor alpha represses GATA-4-mediated transcription via a retinoid-dependent interaction with the cardiac-enriched repressor FOG-2. J Biol Chem. 2003;278(8):5760-7. doi:10.1074/jbc.M208173200  PMID:12480945 
78. Kiiveri S, Liu J, Westerholm-Ormio M, Narita N, Wilson DB, Voutilainen R, Heikinheimo M. Transcription factors GATA-4 and GATA-6 during mouse and human adrenocortical development. Endocr Res. 2002;28(4):647-50. PMID:12530677 
79. Kiiveri S, Liu J, Westerholm-Ormio M, Narita N, Wilson DB, Voutilainen R, Heikinheimo M. Differential expression of GATA-4 and GATA-6 in fetal and adult mouse and human adrenal tissue. Endocrinology. 2002;143(8):3136-43. doi:10.1210/endo.143.8.8939  PMID:12130579 
80. Jacobsen CM, Narita N, Bielinska M, Syder AJ, Gordon JI, Wilson DB. Genetic mosaic analysis reveals that GATA-4 is required for proper differentiation of mouse gastric epithelium. Dev Biol. 2002;241(1):34-46. doi:10.1006/dbio.2001.0424  PMID:11784093 
81. Laitinen MP, Anttonen M, Ketola I, Wilson DB, Ritvos O, Butzow R, Heikinheimo M. Transcription factors GATA-4 and GATA-6 and a GATA family cofactor, FOG-2, are expressed in human ovary and sex cord-derived ovarian tumors. J Clin Endocrinol Metab. 2000;85(9):3476-83. doi:10.1210/jcem.85.9.6828  PMID:10999851 
82. Siltanen S, Anttonen M, Heikkilä P, Narita N, Laitinen M, Ritvos O, Wilson DB, Heikinheimo M. Transcription factor GATA-4 is expressed in pediatric yolk sac tumors. Am J Pathol. 1999;155(6):1823-9. doi:10.1016/S0002-9440(10)65500-9  PMCID:PMC1866939  PMID:10595911 
83. Kiiveri S, Siltanen S, Rahman N, Bielinska M, Lehto VP, Huhtaniemi IT, Muglia LJ, Wilson DB, Heikinheimo M. Reciprocal changes in the expression of transcription factors GATA-4 and GATA-6 accompany adrenocortical tumorigenesis in mice and humans. Mol Med. 1999;5(7):490-501. PMCID:PMC2230442  PMID:10449810 
84. Bielinska M, Narita N, Wilson DB. Distinct roles for visceral endoderm during embryonic mouse development. Int J Dev Biol. 1999;43(3):183-205. PMID:10410899 
85. Pehlivan T, Pober BR, Brueckner M, Garrett S, Slaugh R, Van Rheeden R, Wilson DB, Watson MS, Hing AV. GATA4 haploinsufficiency in patients with interstitial deletion of chromosome region 8p23.1 and congenital heart disease. Am J Med Genet. 1999;83(3):201-6. PMID:10096597 
86. Ketola I, Rahman N, Toppari J, Bielinska M, Porter-Tinge SB, Tapanainen JS, Huhtaniemi IT, Wilson DB, Heikinheimo M. Expression and regulation of transcription factors GATA-4 and GATA-6 in developing mouse testis. Endocrinology. 1999;140(3):1470-80. doi:10.1210/endo.140.3.6587  PMID:10067876 
87. Narita N, Bielinska M, Wilson DB. Cardiomyocyte differentiation by GATA-4-deficient embryonic stem cells. Development. 1997;124(19):3755-64. PMID:9367431 
88. Narita N, Bielinska M, Wilson DB. Wild-type endoderm abrogates the ventral developmental defects associated with GATA-4 deficiency in the mouse. Dev Biol. 1997;189(2):270-274. doi:10.1006/dbio.1997.8684  PMID:9299119 
89. Heikinheimo M, Ermolaeva M, Bielinska M, Rahman NA, Narita N, Huhtaniemi IT, Tapanainen JS, Wilson DB. Expression and hormonal regulation of transcription factors GATA-4 and GATA-6 in the mouse ovary. Endocrinology. 1997;138(8):3505-14. doi:10.1210/endo.138.8.5350  PMID:9231805 
90. Bielinska M, Wilson DB. Induction of yolk sac endoderm in GATA-4-deficient embryoid bodies by retinoic acid. Mech Dev. 1997;65(1-2):43-54. PMID:9256344 
91. Bielinska M, Narita N, Heikinheimo M, Porter SB, Wilson DB. Erythropoiesis and vasculogenesis in embryoid bodies lacking visceral yolk sac endoderm. Blood. 1996;88(10):3720-30. PMID:8916936 
92. Goyal RK, McEvoy L, Wilson DB. Hodgkin disease after renal transplantation in childhood. J Pediatr Hematol Oncol. 1996;18(4):392-5. PMID:8888750 
93. Narita N, Heikinheimo M, Bielinska M, White RA, Wilson DB. The gene for transcription factor GATA-6 resides on mouse chromosome 18 and is expressed in myocardium and vascular smooth muscle. Genomics. 1996;36(2):345-8. doi:10.1006/geno.1996.0472  PMID:8812463 
94. Soudais C, Bielinska M, Heikinheimo M, MacArthur CA, Narita N, Saffitz JE, Simon MC, Leiden JM, Wilson DB. Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro. Development. 1995;121(11):3877-88. PMID:8582296 
95. White RA, Dowler LL, Pasztor LM, Gatson LL, Adkison LR, Angeloni SV, Wilson DB. Assignment of the transcription factor GATA4 gene to human chromosome 8 and mouse chromosome 14: Gata4 is a candidate gene for Ds (disorganization). Genomics. 1995;27(1):20-6. doi:10.1006/geno.1995.1003  PMID:7665171 
96. Bielinska M, Wilson DB. Regulation of J6 gene expression by transcription factor GATA-4. Biochem J. 1995;307 ( Pt 1):183-9. PMCID:PMC1136761  PMID:7717974 
97. Ball RH, Picus D, Goyal RK, Wilson DB, Rader JS. Ovarian artery pseudoaneurysm: diagnosis by Doppler sonography and treatment with transcatheter embolization. J Ultrasound Med. 1995;14(3):250-2. PMID:7760472 
98. Heikinheimo M, Lawshé A, Shackleford GM, Wilson DB, MacArthur CA. Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system. Mech Dev. 1994;48(2):129-38. PMID:7873403 
99. Ip HS, Wilson DB, Heikinheimo M, Tang Z, Ting CN, Simon MC, Leiden JM, Parmacek MS. The GATA-4 transcription factor transactivates the cardiac muscle-specific troponin C promoter-enhancer in nonmuscle cells. Mol Cell Biol. 1994;14(11):7517-26. PMCID:PMC359288  PMID:7935467 
100. Heikinheimo M, Scandrett JM, Wilson DB. Localization of transcription factor GATA-4 to regions of the mouse embryo involved in cardiac development. Dev Biol. 1994;164(2):361-73. doi:10.1006/dbio.1994.1206  PMID:8045339 
101. Arceci RJ, King AA, Simon MC, Orkin SH, Wilson DB. Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol Cell Biol. 1993;13(4):2235-46. PMCID:PMC359544  PMID:8455608 
102. Wilson DB, Wilson MP. Identification and subcellular localization of human rab5b, a new member of the ras-related superfamily of GTPases. J Clin Invest. 1992;89(3):996-1005. doi:10.1172/JCI115683  PMCID:PMC442949  PMID:1541686 
103. Dorfman DM, Wilson DB, Bruns GA, Orkin SH. Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells. J Biol Chem. 1992;267(2):1279-85. PMID:1370462 
104. Wilson DB, Dorfman DM, Orkin SH. A nonerythroid GATA-binding protein is required for function of the human preproendothelin-1 promoter in endothelial cells. Mol Cell Biol. 1990;10(9):4854-62. PMCID:PMC361096  PMID:2388628 
105. Connolly TM, Wilson DB, Bross TE, Majerus PW. Isolation and characterization of the inositol cyclic phosphate products of phosphoinositide cleavage by phospholipase C. Metabolism in cell-free extracts. J Biol Chem. 1986;261(1):122-6. PMID:3001044 
106. Wilson DB, Connolly TM, Bross TE, Majerus PW, Sherman WR, Tyler AN, Rubin LJ, Brown JE. Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells. J Biol Chem. 1985;260(25):13496-501. PMID:2997167 
107. Auchus RJ, Wilson DB, Covey DF, Majerus PW. The 5-hydroxyl of myo-inositol is essential for uptake into HSDM1C1 mouse fibrosarcoma cells. Biochem Biophys Res Commun. 1985;130(3):1139-46. PMID:4026861 
108. Wilson DB, Bross TE, Sherman WR, Berger RA, Majerus PW. Inositol cyclic phosphates are produced by cleavage of phosphatidylphosphoinositols (polyphosphoinositides) with purified sheep seminal vesicle phospholipase C enzymes. Proc Natl Acad Sci U S A. 1985;82(12):4013-7. PMCID:PMC397924  PMID:2987959 
109. Wilson DB, Neufeld EJ, Majerus PW. Phosphoinositide interconversion in thrombin-stimulated human platelets. J Biol Chem. 1985;260(2):1046-51. PMID:2981829 
110. Wilson DB, Bross TE, Hofmann SL, Majerus PW. Hydrolysis of polyphosphoinositides by purified sheep seminal vesicle phospholipase C enzymes. J Biol Chem. 1984;259(19):11718-24. PMID:6090445 
111. Wilson DB, Salem HH, Mruk JS, Maruyama I, Majerus PW. Biosynthesis of coagulation Factor V by a human hepatocellular carcinoma cell line. J Clin Invest. 1984;73(3):654-8. doi:10.1172/JCI111256  PMCID:PMC425065  PMID:6200498 
112. Neufeld EJ, Wilson DB, Sprecher H, Majerus PW. High affinity esterification of eicosanoid precursor fatty acids by platelets. J Clin Invest. 1983;72(1):214-20. PMCID:PMC1129176  PMID:6308046 
113. Wilson DB, Prescott SM, Majerus PW. Discovery of an arachidonoyl coenzyme A synthetase in human platelets. J Biol Chem. 1982;257(7):3510-5. PMID:7061494 
114. Wilson DB, Ellsworth JL, Jackson RL. Net transfer of phosphatidylcholine from plasma low density lipoproteins to sphingomyelin-apolipoprotein A-II complexes by bovine liver and human plasma phospholipid exchange proteins. Biochim Biophys Acta. 1980;620(3):550-61. PMID:7236658 
115. Jackson RL, Glueck CJ. Exchange of phospholipids between unilamellar vesicles of 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine and plasma very low density lipoproteins. Biochim Biophys Acta. 1979;557(1):79-85. PMID:232989