David B. Wilson, M.D., Ph.D.  wilson_d@wustl.edu

Professor of Pediatrics, Hematology and Oncology
Developmental BiologyHematology and Oncology

phone: (314) 454-6018

Clinical Interests

Dr. Wilson is a physician-scientist in the Division of Pediatric Hematology-Oncology. Areas of clinical interest include bone marrow failure, hemolytic anemias, and coagulation disorders. His basic research laboratory studies the role of transcription factors in development and oncogenesis.

Education

  • BA, Kalamazoo College1980
  • MD, Washington University School of Medicine1986
  • PhD, Washington University School of Medicine1986

Training

  • Pediatric Resident, Boston Children's Hospital1986 - 1988
  • Hematology/Oncology Fellow, Dana Farber Cancer Inst1988 - 1991

Licensure and Board Certification

  • MO, Physician 1993
  • Pediatrics 1993
  • Pediatric Hematology/Oncology 1996
  • IL, Physician 2015

Honors

  • Honors in Chemistry, Kalamazoo College1980
  • Phi Beta Kappa1980
  • Carter Prize for Achievement in the Medical Curriculum1981
  • Lowry Prize in Pharmacology1982
  • Alpha Omega Alpha1986
  • McDonnell Scholars Award in Oncology1992
  • Pfizer Junior Faculty Award in Cardiovascular Biology1992
  • March of Dimes Basil O'Connor Award1993
  • American Heart Association Established Investigator Award1995
  • American Society for Clinical Investigation1998

Recent Publications view all (95)


Publication Co-Authors

  1. Nkx2-5 and Sarcospan genetically interact in the development of the muscular ventricular septum of the heart. Sci Rep. 2017;7:46438. PMID:28406175 
  2. Downregulation of transcription factor GATA4 sensitizes human hepatoblastoma cells to doxorubicin-induced apoptosis. Tumour Biol. 2017;39(3):1010428317695016. PMID:28349834 
  3. GLI1+ progenitor cells in the adrenal capsule of the adult mouse give rise to heterotopic gonadal-like tissue. Mol Cell Endocrinol. 2016;441:164–175. doi:10.1016/j.mce.2016.08.043  PMID:27585489 
  4. GATA4 regulates blood-testis barrier function and lactate metabolism in mouse Sertoli cells. Endocrinology. 2016;157(6):2416-31. doi:10.1210/en.2015-1927  PMCID:PMC4891789  PMID:26974005 
  5. Hematologic outcomes after total splenectomy and partial splenectomy for congenital hemolytic anemia. J Pediatr Surg. 2016;51(1):122-7. doi:10.1016/j.jpedsurg.2015.10.028  PMID:26613837 
  6. GATA4 is a key regulator of steroidogenesis and glycolysis in mouse Leydig cells. Endocrinology. 2015;156(5):1860-1872. doi:10.1210/en.2014-1931  PMCID:PMC4398762  PMID:25668067 
  7. The maternal-age-associated risk of congenital heart disease is modifiable. Nature. 2015;520(7546):230-33. doi:10.1038/nature14361  PMCID:PMC4393370  PMID:25830876 
  8. Clinical outcomes of splenectomy in children: report of the splenectomy in congenital hemolytic anemia registry. Am J Hematol. 2015;90(3):187-92. doi:10.1002/ajh.23888  PMCID:PMC4333061  PMID:25382665 
  9. Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret. Mol Cell Endocrinol. 2015;399:122-30. doi:10.1016/j.mce.2014.09.029  PMCID:PMC4262703  PMID:25289806 
  10. Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival. J Exp Med. 2014;211(8):1525-31. doi:10.1084/jem.20140570  PMCID:PMC4113942  PMID:25024137 
  11. Expression of Wnt and TGF-β pathway components and key adrenal transcription factors in adrenocortical tumors: association to carcinoma aggressiveness. Pathol Res Pract. 2013;209(8):503-9. doi:10.1016/j.prp.2013.06.002  PMCID:PMC3777642  PMID:23866946 
  12. A family with Hoyeraal-Hreidarsson syndrome and four variants in two genes of the telomerase core complex. Pediatr Blood Cancer. 2013;60(6):E4-6. doi:10.1002/pbc.24389  PMCID:PMC3860171  PMID:23335200 
  13. Laser capture microdissection-reduced representation bisulfite sequencing (LCM-RRBS) maps changes in DNA methylation associated with gonadectomy-induced adrenocortical neoplasia in the mouse. Nucleic Acids Res. 2013;41(11):e116. doi:10.1093/nar/gkt230  PMCID:PMC3675465  PMID:23589626 
  14. Conditional mutagenesis of Gata6 in SF1-positive cells causes gonadal-like differentiation in the adrenal cortex of mice. Endocrinology. 2013;154(5):1754-67. doi:10.1210/en.2012-1892  PMCID:PMC3628026  PMID:23471215 
  15. GATA4 is a critical regulator of gonadectomy-induced adrenocortical tumorigenesis in mice. Endocrinology. 2012;153(6):2599-611. doi:10.1210/en.2011-2135  PMCID:PMC3359595  PMID:22461617 
  16. Comparative effectiveness of different types of splenectomy for children with congenital hemolytic anemias. J Pediatr. 2012;160(4):684-689.e13. doi:10.1016/j.jpeds.2011.09.030  PMID:22050869 
  17. The role of myotubularin-related phosphatases in the control of autophagy and programmed cell death. Adv Biol Regul. 2012;52(1):282-9. doi:10.1016/j.advenzreg.2011.10.001  PMCID:PMC3565244  PMID:22056831 
  18. Transcription factor GATA-4 is abundantly expressed in childhood but not in adult liver tumors. J Pediatr Gastroenterol Nutr. 2012;54(1):101-8. doi:10.1097/MPG.0b013e31822d52cf  PMID:21788913 
  19. GATA4 deficiency impairs ovarian function in adult mice. Biol Reprod. 2011;84(5):1033-44. doi:10.1095/biolreprod.110.086850  PMCID:PMC3080425  PMID:21248289 
  20. GATA4 regulates Sertoli cell function and fertility in adult male mice. Mol Cell Endocrinol. 2011;333(1):85-95. doi:10.1016/j.mce.2010.12.019  PMCID:PMC3026658  PMID:21172404 
  21. GATA4 protects granulosa cell tumors from TRAIL-induced apoptosis. Endocr Relat Cancer. 2010;17(3):709-17. doi:10.1677/ERC-10-0041  PMID:20554787 
  22. Expression of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) and its role in neural tube defects. Adv Enzyme Regul. 2010;50(1):365-72. doi:10.1016/j.advenzreg.2009.10.017  PMCID:PMC2862868  PMID:19914276 
  23. Acquired monosomy 7 myelodysplastic syndrome in a child with clinical features suggestive of dyskeratosis congenita and IMAGe association. Pediatr Blood Cancer. 2010;54(1):154-7. doi:10.1002/pbc.22283  PMID:19760774 
  24. Pilocytic astrocytoma in a child with Noonan syndrome. Pediatr Blood Cancer. 2009;53(6):1147-9. doi:10.1002/pbc.22193  PMID:19621452 
  25. Downsizing to resectability of a large solid and cystic papillary tumor of the pancreas by single-agent chemotherapy. J Pediatr Surg. 2009;44(10):e23-5. doi:10.1016/j.jpedsurg.2009.07.026  PMID:19853735 
  26. Enhanced expression of transcription factor GATA-4 in inflammatory bowel disease and its possible regulation by TGF-beta1. J Clin Immunol. 2009;29(4):444-53. doi:10.1007/s10875-009-9292-x  PMID:19353247 
  27. Neural tube defects in mice with reduced levels of inositol 1,3,4-trisphosphate 5/6-kinase. Proc Natl Acad Sci U S A. 2009;106(24):9831-5. doi:10.1073/pnas.0904172106  PMCID:PMC2701051  PMID:19482943 
  28. TINF2 mutations in children with severe aplastic anemia. Pediatr Blood Cancer. 2009;52(5):687. doi:10.1002/pbc.21903  PMCID:PMC2860792  PMID:19090550 
  29. TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements. Blood. 2009;113(2):309-16. doi:10.1182/blood-2008-07-166421  PMCID:PMC2615648  PMID:18931339 
  30. Cytochrome b5 expression in gonadectomy-induced adrenocortical neoplasms of the domestic ferret (Mustela putorius furo). Vet Pathol. 2008;45(4):439-42. doi:10.1354/vp.45-4-439  PMCID:PMC2497446  PMID:18587089 
  31. Safety, efficacy, and immune reconstitution after rituximab therapy in pediatric patients with chronic or refractory hematologic autoimmune cytopenias. Pediatr Blood Cancer. 2008;50(4):822-5. doi:10.1002/pbc.21264  PMID:17570702 
  32. Complex inheritance pattern of dyskeratosis congenita in two families with 2 different mutations in the telomerase reverse transcriptase gene. Blood. 2008;111(3):1128-30. doi:10.1182/blood-2007-10-120907  PMCID:PMC2214749  PMID:18042801 
  33. Telomerase reverse transcriptase haploinsufficiency and telomere length in individuals with 5p- syndrome. Aging Cell. 2007;6(5):689-97. doi:10.1111/j.1474-9726.2007.00324.x  PMCID:PMC2583393  PMID:17875000 
  34. Molecular genetics of congenital diaphragmatic defects. Ann Med. 2007;39(4):261-74. doi:10.1080/07853890701326883  PMCID:PMC2174621  PMID:17558598 
  35. Severe hypertriglyceridemia in an infant with red cell pyruvate kinase deficiency. Indian Pediatr. 2007;44(4):303-5. PMID:17468529 
  36. Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects. Dev Biol. 2007;301(2):602-14. doi:10.1016/j.ydbio.2006.09.050  PMCID:PMC1808541  PMID:17069789 
  37. GATA-4 is required for sex steroidogenic cell development in the fetal mouse. Dev Dyn. 2007;236(1):203-13. doi:10.1002/dvdy.21004  PMCID:PMC2174205  PMID:17096405 
  38. Cells depleted for RPS19, a protein associated with Diamond Blackfan Anemia, show defects in 18S ribosomal RNA synthesis and small ribosomal subunit production. Blood Cells Mol Dis. 2007;39(1):35-43. doi:10.1016/j.bcmd.2007.02.001  PMID:17376718 
  39. A four base pair insertion in exon 1 of the RPS19 gene is a common polymorphism in African-Americans. Br J Haematol. 2006;135(5):745-746. doi:10.1111/j.1365-2141.2006.06368.x  PMID:17107358 
  40. Low frequency of telomerase RNA mutations among children with aplastic anemia or myelodysplastic syndrome. J Pediatr Hematol Oncol. 2006;28(7):450-3. doi:10.1097/01.mph.0000212952.58597.84  PMID:16825992 
  41. GATA-4 is a granulosa cell factor employed in inhibin-alpha activation by the TGF-beta pathway. J Mol Endocrinol. 2006;36(3):557-68. doi:10.1677/jme.1.01962  PMID:16720723 
  42. Gonadectomy-induced adrenocortical neoplasia in the domestic ferret (Mustela putorius furo) and laboratory mouse. Vet Pathol. 2006;43(2):97-117. doi:10.1354/vp.43-2-97  PMID:16537928 
  43. GATA-4:FOG interactions regulate gastric epithelial development in the mouse. Dev Dyn. 2005;234(2):355-62. doi:10.1002/dvdy.20552  PMID:16127717 
  44. Gonadotropin-induced adrenocortical neoplasia in NU/J nude mice. Endocrinology. 2005;146(9):3975-84. doi:10.1210/en.2004-1643  PMID:15919738 
  45. A novel reduced-intensity stem cell transplant regimen for nonmalignant disorders. Bone Marrow Transplant. 2005;35(4):345-52. doi:10.1038/sj.bmt.1704795  PMID:15592491 
  46. Nude mice as a model for gonadotropin-induced adrenocortical neoplasia. Endocr Res. 2004;30(4):913-7. PMID:15666844 
  47. GATA-4, GATA-5, and GATA-6 activate the rat liver fatty acid binding protein gene in concert with HNF-1alpha. Am J Physiol Gastrointest Liver Physiol. 2004;287(5):G1086-99. doi:10.1152/ajpgi.00421.2003  PMID:14715527 
  48. Transcription factor GATA-6 is expressed in the endocrine and GATA-4 in the exocrine pancreas. Mol Cell Endocrinol. 2004;226(1-2):51-7. doi:10.1016/j.mce.2004.06.007  PMID:15489005 
  49. Adrenocortical tumorigenesis in transgenic mice expressing the inhibin alpha-subunit promoter/simian virus 40 T-antigen transgene: relationship between ectopic expression of luteinizing hormone receptor and transcription factor GATA-4. Mol Endocrinol. 2004;18(10):2553-69. doi:10.1210/me.2002-0282  PMID:15256532 
  50. Transcription factor GATA-4 is a marker of anaplasia in adrenocortical neoplasms of the domestic ferret (Mustela putorius furo). Vet Pathol. 2004;41(4):446-9. doi:10.1354/vp.41-4-446  PMID:15232151 
  51. Neutropenic enterocolitis as a presenting complication of acute lymphoblastic leukemia: an unusual case marked by delayed perforation of the descending colon. J Pediatr Surg. 2004;39(7):e18-20. PMID:15213940 
  52. Hypopigmentation from imatinib mesylate (Gleevec). J Pediatr Hematol Oncol. 2004;26(3):214. PMID:15125619 
  53. Isolated CNS relapse following stem cell transplantation for juvenile myelomonocytic leukemia. J Pediatr Hematol Oncol. 2003;25(11):910-3. PMID:14608204 
  54. Sudden unexplained hemolysis occurring in an infant due to presumed Loxosceles envenomation. J Emerg Med. 2003;25(3):277-82. PMID:14585455 
  55. Mouse strain susceptibility to gonadectomy-induced adrenocortical tumor formation correlates with the expression of GATA4 and luteinizing hormone receptor. Endocrinology. 2003;144(9):4123-33. doi:10.1210/en.2003-0126  PMID:12933687 
  56. Human telomerase RNA mutations and bone marrow failure. Lancet. 2003;361(9373):1993-4. doi:10.1016/S0140-6736(03)13575-1  PMID:12801777 
  57. Retinoid X receptor alpha represses GATA-4-mediated transcription via a retinoid-dependent interaction with the cardiac-enriched repressor FOG-2. J Biol Chem. 2003;278(8):5760-7. doi:10.1074/jbc.M208173200  PMID:12480945 
  58. Transcription factors GATA-4 and GATA-6 during mouse and human adrenocortical development. Endocr Res. 2002;28(4):647-50. PMID:12530677 
  59. Differential expression of GATA-4 and GATA-6 in fetal and adult mouse and human adrenal tissue. Endocrinology. 2002;143(8):3136-43. doi:10.1210/endo.143.8.8939  PMID:12130579 
  60. Genetic mosaic analysis reveals that GATA-4 is required for proper differentiation of mouse gastric epithelium. Dev Biol. 2002;241(1):34-46. doi:10.1006/dbio.2001.0424  PMID:11784093 
  61. Transcription factors GATA-4 and GATA-6 and a GATA family cofactor, FOG-2, are expressed in human ovary and sex cord-derived ovarian tumors. J Clin Endocrinol Metab. 2000;85(9):3476-83. doi:10.1210/jcem.85.9.6828  PMID:10999851 
  62. Transcription factor GATA-4 is expressed in pediatric yolk sac tumors. Am J Pathol. 1999;155(6):1823-9. doi:10.1016/S0002-9440(10)65500-9  PMCID:PMC1866939  PMID:10595911 
  63. Reciprocal changes in the expression of transcription factors GATA-4 and GATA-6 accompany adrenocortical tumorigenesis in mice and humans. Mol Med. 1999;5(7):490-501. PMCID:PMC2230442  PMID:10449810 
  64. Distinct roles for visceral endoderm during embryonic mouse development. Int J Dev Biol. 1999;43(3):183-205. PMID:10410899 
  65. GATA4 haploinsufficiency in patients with interstitial deletion of chromosome region 8p23.1 and congenital heart disease. Am J Med Genet. 1999;83(3):201-6. PMID:10096597 
  66. Expression and regulation of transcription factors GATA-4 and GATA-6 in developing mouse testis. Endocrinology. 1999;140(3):1470-80. doi:10.1210/endo.140.3.6587  PMID:10067876 
  67. Cardiomyocyte differentiation by GATA-4-deficient embryonic stem cells. Development. 1997;124(19):3755-64. PMID:9367431 
  68. Wild-type endoderm abrogates the ventral developmental defects associated with GATA-4 deficiency in the mouse. Dev Biol. 1997;189(2):270-274. doi:10.1006/dbio.1997.8684  PMID:9299119 
  69. Expression and hormonal regulation of transcription factors GATA-4 and GATA-6 in the mouse ovary. Endocrinology. 1997;138(8):3505-14. doi:10.1210/endo.138.8.5350  PMID:9231805 
  70. Induction of yolk sac endoderm in GATA-4-deficient embryoid bodies by retinoic acid. Mech Dev. 1997;65(1-2):43-54. PMID:9256344 
  71. Erythropoiesis and vasculogenesis in embryoid bodies lacking visceral yolk sac endoderm. Blood. 1996;88(10):3720-30. PMID:8916936 
  72. Hodgkin disease after renal transplantation in childhood. J Pediatr Hematol Oncol. 1996;18(4):392-5. PMID:8888750 
  73. The gene for transcription factor GATA-6 resides on mouse chromosome 18 and is expressed in myocardium and vascular smooth muscle. Genomics. 1996;36(2):345-8. doi:10.1006/geno.1996.0472  PMID:8812463 
  74. Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro. Development. 1995;121(11):3877-88. PMID:8582296 
  75. Assignment of the transcription factor GATA4 gene to human chromosome 8 and mouse chromosome 14: Gata4 is a candidate gene for Ds (disorganization). Genomics. 1995;27(1):20-6. doi:10.1006/geno.1995.1003  PMID:7665171 
  76. Regulation of J6 gene expression by transcription factor GATA-4. Biochem J. 1995;307 ( Pt 1):183-9. PMCID:PMC1136761  PMID:7717974 
  77. Ovarian artery pseudoaneurysm: diagnosis by Doppler sonography and treatment with transcatheter embolization. J Ultrasound Med. 1995;14(3):250-2. PMID:7760472 
  78. Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system. Mech Dev. 1994;48(2):129-38. PMID:7873403 
  79. The GATA-4 transcription factor transactivates the cardiac muscle-specific troponin C promoter-enhancer in nonmuscle cells. Mol Cell Biol. 1994;14(11):7517-26. PMCID:PMC359288  PMID:7935467 
  80. Localization of transcription factor GATA-4 to regions of the mouse embryo involved in cardiac development. Dev Biol. 1994;164(2):361-73. doi:10.1006/dbio.1994.1206  PMID:8045339 
  81. Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol Cell Biol. 1993;13(4):2235-46. PMCID:PMC359544  PMID:8455608 
  82. Identification and subcellular localization of human rab5b, a new member of the ras-related superfamily of GTPases. J Clin Invest. 1992;89(3):996-1005. doi:10.1172/JCI115683  PMCID:PMC442949  PMID:1541686 
  83. Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells. J Biol Chem. 1992;267(2):1279-85. PMID:1370462 
  84. A nonerythroid GATA-binding protein is required for function of the human preproendothelin-1 promoter in endothelial cells. Mol Cell Biol. 1990;10(9):4854-62. PMCID:PMC361096  PMID:2388628 
  85. Isolation and characterization of the inositol cyclic phosphate products of phosphoinositide cleavage by phospholipase C. Metabolism in cell-free extracts. J Biol Chem. 1986;261(1):122-6. PMID:3001044 
  86. Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells. J Biol Chem. 1985;260(25):13496-501. PMID:2997167 
  87. The 5-hydroxyl of myo-inositol is essential for uptake into HSDM1C1 mouse fibrosarcoma cells. Biochem Biophys Res Commun. 1985;130(3):1139-46. PMID:4026861 
  88. Inositol cyclic phosphates are produced by cleavage of phosphatidylphosphoinositols (polyphosphoinositides) with purified sheep seminal vesicle phospholipase C enzymes. Proc Natl Acad Sci U S A. 1985;82(12):4013-7. PMCID:PMC397924  PMID:2987959 
  89. Phosphoinositide interconversion in thrombin-stimulated human platelets. J Biol Chem. 1985;260(2):1046-51. PMID:2981829 
  90. Hydrolysis of polyphosphoinositides by purified sheep seminal vesicle phospholipase C enzymes. J Biol Chem. 1984;259(19):11718-24. PMID:6090445 
  91. Biosynthesis of coagulation Factor V by a human hepatocellular carcinoma cell line. J Clin Invest. 1984;73(3):654-8. doi:10.1172/JCI111256  PMCID:PMC425065  PMID:6200498 
  92. High affinity esterification of eicosanoid precursor fatty acids by platelets. J Clin Invest. 1983;72(1):214-20. PMCID:PMC1129176  PMID:6308046 
  93. Discovery of an arachidonoyl coenzyme A synthetase in human platelets. J Biol Chem. 1982;257(7):3510-5. PMID:7061494 
  94. Net transfer of phosphatidylcholine from plasma low density lipoproteins to sphingomyelin-apolipoprotein A-II complexes by bovine liver and human plasma phospholipid exchange proteins. Biochim Biophys Acta. 1980;620(3):550-61. PMID:7236658 
  95. Exchange of phospholipids between unilamellar vesicles of 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine and plasma very low density lipoproteins. Biochim Biophys Acta. 1979;557(1):79-85. PMID:232989 
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