David B. Wilson, M.D., Ph.D.  wilson_d@wustl.edu

Professor of Pediatrics, Hematology and Oncology
Developmental BiologyHematology and Oncology

phone: (314) 454-6018

Clinical Interests

Dr. Wilson is a physician-scientist in the Division of Pediatric Hematology-Oncology. Areas of clinical interest include bone marrow failure, hemolytic anemias, and coagulation disorders. His basic research laboratory studies the role of transcription factors in development and oncogenesis.

Education

  • B.A., Kalamazoo College1980
  • M.D., Washington University School of Medicine1986
  • Ph.D., Washington University School of Medicine1986

Training

  • Pediatric Resident, Boston Children's Hospital1986 - 1988
  • Hematology/Oncology Fellow, Dana Farber Cancer Inst1988 - 1991

Licensure and Board Certification

  • MO, Physician1993
  • Pediatrics1993
  • Pediatric Hematology/Oncology1996
  • IL, Physician2015

Honors

  • Honors in Chemistry, Kalamazoo College1980
  • Phi Beta Kappa1980
  • Carter Prize for Achievement in the Medical Curriculum1981
  • Lowry Prize in Pharmacology1982
  • Alpha Omega Alpha1986
  • McDonnell Scholars Award in Oncology1992
  • Pfizer Junior Faculty Award in Cardiovascular Biology1992
  • March of Dimes Basil O'Connor Award1993
  • American Heart Association Established Investigator Award1995
  • American Society for Clinical Investigation1998

Recent Publications view all (93)


Publication Co-Authors

  1. Dörner J, Rodriguez VM, Ziegler R, Röhrig T, Cochran RS, Götz RM, Levin MD, Pihlajoki M, Heikinheimo M, Wilson DB. GLI1+ progenitor cells in the adrenal capsule of the adult mouse give rise to heterotopic gonadal-like tissue. Mol Cell Endocrinol. 2016;441:164–175. doi:10.1016/j.mce.2016.08.043  PMID:27585489  
  2. Schrade A, Kyrönlahti A, Akinrinade O, Pihlajoki M, Fischer S, Rodriguez VM, Otte K, Velagapudi V, Toppari J, Wilson DB, Heikinheimo M. GATA4 regulates blood-testis barrier function and lactate metabolism in mouse Sertoli cells. Endocrinology. 2016;157(6):2416-31. doi:10.1210/en.2015-1927  PMCID:PMC4891789  PMID:26974005  
  3. Englum BR, Rothman J, Leonard S, Reiter A, Thornburg C, Brindle M, Wright N, Heeney MM, Jason Smithers C, Brown RL, Kalfa T, Langer JC, Cada M, Oldham KT, Scott JP, St Peter SD, Sharma M, Davidoff AM, Nottage K, Bernabe K, Wilson DB, Dutta S, Glader B, Crary SE, Dassinger MS, Dunbar L, Islam S, Kumar M, Rescorla F, Bruch S, Campbell A, Austin M, Sidonio R, Blakely ML, Rice HE, Splenectomy in Congenital Hemolytic Anemia Consortium. Hematologic outcomes after total splenectomy and partial splenectomy for congenital hemolytic anemia. J Pediatr Surg. 2016;51(1):122-7. doi:10.1016/j.jpedsurg.2015.10.028  PMID:26613837  
  4. Schrade A, Kyrönlahti A, Akinrinade O, Pihlajoki M, Häkkinen M, Fischer S, Alastalo TP, Velagapudi V, Toppari J, Wilson DB, Heikinheimo M. GATA4 is a key regulator of steroidogenesis and glycolysis in mouse Leydig cells. Endocrinology. 2015;156(5):1860-1872. doi:10.1210/en.2014-1931  PMCID:PMC4398762  PMID:25668067  
  5. Schulkey CE, Regmi SD, Magnan RA, Danzo MT, Luther H, Hutchinson AK, Panzer AA, Grady MM, Wilson DB, Jay PY. The maternal-age-associated risk of congenital heart disease is modifiable. Nature. 2015;520(7546):230-33. doi:10.1038/nature14361  PMCID:PMC4393370  PMID:25830876  
  6. Rice HE, Englum BR, Rothman J, Leonard S, Reiter A, Thornburg C, Brindle M, Wright N, Heeney MM, Smithers C, Brown RL, Kalfa T, Langer JC, Cada M, Oldham KT, Scott JP, St Peter S, Sharma M, Davidoff AM, Nottage K, Bernabe K, Wilson DB, Dutta S, Glader B, Crary SE, Dassinger MS, Dunbar L, Islam S, Kumar M, Rescorla F, Bruch S, Campbell A, Austin M, Sidonio R, Blakely ML, Splenectomy in Congenital Hemolytic Anemia (SICHA) Consortium. Clinical outcomes of splenectomy in children: report of the splenectomy in congenital hemolytic anemia registry. Am J Hematol. 2015;90(3):187-92. doi:10.1002/ajh.23888  PMCID:PMC4333061  PMID:25382665  
  7. Schillebeeckx M, Pihlajoki M, Gretzinger E, Yang W, Thol F, Hiller T, Löbs AK, Röhrig T, Schrade A, Cochran R, Jay PY, Heikinheimo M, Mitra RD, Wilson DB. Novel markers of gonadectomy-induced adrenocortical neoplasia in the mouse and ferret. Mol Cell Endocrinol. 2015;399:122-30. doi:10.1016/j.mce.2014.09.029  PMCID:PMC4262703  PMID:25289806  
  8. Gautier EL, Ivanov S, Williams JW, Huang SC, Marcelin G, Fairfax K, Wang PL, Francis JS, Leone P, Wilson DB, Artyomov MN, Pearce EJ, Randolph GJ. Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival. J Exp Med. 2014;211(8):1525-31. doi:10.1084/jem.20140570  PMCID:PMC4113942  PMID:25024137  
  9. Parviainen H, Schrade A, Kiiveri S, Prunskaite-Hyyryläinen R, Haglund C, Vainio S, Wilson DB, Arola J, Heikinheimo M. Expression of Wnt and TGF-β pathway components and key adrenal transcription factors in adrenocortical tumors: association to carcinoma aggressiveness. Pathol Res Pract. 2013;209(8):503-9. doi:10.1016/j.prp.2013.06.002  PMCID:PMC3777642  PMID:23866946  
  10. Schillebeeckx M, Schrade A, Löbs AK, Pihlajoki M, Wilson DB, Mitra RD. Laser capture microdissection-reduced representation bisulfite sequencing (LCM-RRBS) maps changes in DNA methylation associated with gonadectomy-induced adrenocortical neoplasia in the mouse. Nucleic Acids Res. 2013;41(11):e116. doi:10.1093/nar/gkt230  PMCID:PMC3675465  PMID:23589626  
  11. Vogiatzi P, Perdigones N, Mason PJ, Wilson DB, Bessler M. A family with Hoyeraal-Hreidarsson syndrome and four variants in two genes of the telomerase core complex. Pediatr Blood Cancer. 2013;60(6):E4-6. doi:10.1002/pbc.24389  PMCID:PMC3860171  PMID:23335200  
  12. Pihlajoki M, Gretzinger E, Cochran R, Kyrönlahti A, Schrade A, Hiller T, Sullivan L, Shoykhet M, Schoeller EL, Brooks MD, Heikinheimo M, Wilson DB. Conditional mutagenesis of Gata6 in SF1-positive cells causes gonadal-like differentiation in the adrenal cortex of mice. Endocrinology. 2013;154(5):1754-67. doi:10.1210/en.2012-1892  PMCID:PMC3628026  PMID:23471215  
  13. Krachulec J, Vetter M, Schrade A, Löbs AK, Bielinska M, Cochran R, Kyrönlahti A, Pihlajoki M, Parviainen H, Jay PY, Heikinheimo M, Wilson DB. GATA4 is a critical regulator of gonadectomy-induced adrenocortical tumorigenesis in mice. Endocrinology. 2012;153(6):2599-611. doi:10.1210/en.2011-2135  PMCID:PMC3359595  PMID:22461617  
  14. Rice HE, Crary SE, Langer JC, Kemper AR, Splenectomy in Congenital Hemolytic Anemia Consortium. Comparative effectiveness of different types of splenectomy for children with congenital hemolytic anemias. J Pediatr. 2012;160(4):684-689.e13. doi:10.1016/j.jpeds.2011.09.030  PMID:22050869  
  15. Zou J, Majerus PW, Wilson DB, Schrade A, Chang SC, Wilson MP. The role of myotubularin-related phosphatases in the control of autophagy and programmed cell death. Adv Biol Regul. 2012;52(1):282-9. doi:10.1016/j.advenzreg.2011.10.001  PMCID:PMC3565244  PMID:22056831  
  16. Soini T, Haveri H, Elo JM, Kauppinen M, Kyrönlahti A, Salo MK, Lohi J, Andersson LC, Wilson DB, Heikinheimo M. Transcription factor GATA-4 is abundantly expressed in childhood but not in adult liver tumors. J Pediatr Gastroenterol Nutr. 2012;54(1):101-8. doi:10.1097/MPG.0b013e31822d52cf  PMID:21788913  
  17. Kyrönlahti A, Vetter M, Euler R, Bielinska M, Jay PY, Anttonen M, Heikinheimo M, Wilson DB. GATA4 deficiency impairs ovarian function in adult mice. Biol Reprod. 2011;84(5):1033-44. doi:10.1095/biolreprod.110.086850  PMCID:PMC3080425  PMID:21248289  
  18. Kyrönlahti A, Euler R, Bielinska M, Schoeller EL, Moley KH, Toppari J, Heikinheimo M, Wilson DB. GATA4 regulates Sertoli cell function and fertility in adult male mice. Mol Cell Endocrinol. 2011;333(1):85-95. doi:10.1016/j.mce.2010.12.019  PMCID:PMC3026658  PMID:21172404  
  19. Kyrönlahti A, Kauppinen M, Lind E, Unkila-Kallio L, Butzow R, Klefström J, Wilson DB, Anttonen M, Heikinheimo M. GATA4 protects granulosa cell tumors from TRAIL-induced apoptosis. Endocr Relat Cancer. 2010;17(3):709-17. doi:10.1677/ERC-10-0041  PMID:20554787  
  20. Majerus PW, Wilson DB, Zhang C, Nicholas PJ, Wilson MP. Expression of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) and its role in neural tube defects. Adv Enzyme Regul. 2010;50(1):365-72. doi:10.1016/j.advenzreg.2009.10.017  PMCID:PMC2862868  PMID:19914276  
  21. McDonald S, Wilson DB, Pumbo E, Kulkarni S, Mason PJ, Else T, Bessler M, Ferkol T, Shenoy S. Acquired monosomy 7 myelodysplastic syndrome in a child with clinical features suggestive of dyskeratosis congenita and IMAGe association. Pediatr Blood Cancer. 2010;54(1):154-7. doi:10.1002/pbc.22283  PMID:19760774  
  22. Schuettpelz LG, McDonald S, Whitesell K, Desruisseau DM, Grange DK, Gurnett CA, Wilson DB. Pilocytic astrocytoma in a child with Noonan syndrome. Pediatr Blood Cancer. 2009;53(6):1147-9. doi:10.1002/pbc.22193  PMID:19621452  
  23. Kanter J, Wilson DB, Strasberg S. Downsizing to resectability of a large solid and cystic papillary tumor of the pancreas by single-agent chemotherapy. J Pediatr Surg. 2009;44(10):e23-5. doi:10.1016/j.jpedsurg.2009.07.026  PMID:19853735  
  24. Haveri H, Ashorn M, Iltanen S, Wilson DB, Andersson LC, Heikinheimo M. Enhanced expression of transcription factor GATA-4 in inflammatory bowel disease and its possible regulation by TGF-beta1. J Clin Immunol. 2009;29(4):444-53. doi:10.1007/s10875-009-9292-x  PMID:19353247  
  25. Wilson MP, Hugge C, Bielinska M, Nicholas P, Majerus PW, Wilson DB. Neural tube defects in mice with reduced levels of inositol 1,3,4-trisphosphate 5/6-kinase. Proc Natl Acad Sci U S A. 2009;106(24):9831-5. doi:10.1073/pnas.0904172106  PMCID:PMC2701051  PMID:19482943  
  26. Du HY, Mason PJ, Bessler M, Wilson DB. TINF2 mutations in children with severe aplastic anemia. Pediatr Blood Cancer. 2009;52(5):687. doi:10.1002/pbc.21903  PMCID:PMC2860792  PMID:19090550  
  27. Du HY, Pumbo E, Ivanovich J, An P, Maziarz RT, Reiss UM, Chirnomas D, Shimamura A, Vlachos A, Lipton JM, Goyal RK, Goldman F, Wilson DB, Mason PJ, Bessler M. TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements. Blood. 2009;113(2):309-16. doi:10.1182/blood-2008-07-166421  PMCID:PMC2615648  PMID:18931339  
  28. Wagner S, Kiupel M, Peterson RA 2nd, Heikinheimo M, Wilson DB. Cytochrome b5 expression in gonadectomy-induced adrenocortical neoplasms of the domestic ferret (Mustela putorius furo). Vet Pathol. 2008;45(4):439-42. doi:10.1354/vp.45-4-439  PMCID:PMC2497446  PMID:18587089  
  29. Rao A, Kelly M, Musselman M, Ramadas J, Wilson D, Grossman W, Shenoy S. Safety, efficacy, and immune reconstitution after rituximab therapy in pediatric patients with chronic or refractory hematologic autoimmune cytopenias. Pediatr Blood Cancer. 2008;50(4):822-5. doi:10.1002/pbc.21264  PMID:17570702  
  30. Du HY, Pumbo E, Manley P, Field JJ, Bayliss SJ, Wilson DB, Mason PJ, Bessler M. Complex inheritance pattern of dyskeratosis congenita in two families with 2 different mutations in the telomerase reverse transcriptase gene. Blood. 2008;111(3):1128-30. doi:10.1182/blood-2007-10-120907  PMCID:PMC2214749  PMID:18042801  
  31. Du HY, Idol R, Robledo S, Ivanovich J, An P, Londono-Vallejo A, Wilson DB, Mason PJ, Bessler M. Telomerase reverse transcriptase haploinsufficiency and telomere length in individuals with 5p- syndrome. Aging Cell. 2007;6(5):689-97. doi:10.1111/j.1474-9726.2007.00324.x  PMCID:PMC2583393  PMID:17875000  
  32. Bielinska M, Jay PY, Erlich JM, Mannisto S, Urban Z, Heikinheimo M, Wilson DB. Molecular genetics of congenital diaphragmatic defects. Ann Med. 2007;39(4):261-74. doi:10.1080/07853890701326883  PMCID:PMC2174621  PMID:17558598  
  33. Rao A, Hulbert M, Wilson DB. Severe hypertriglyceridemia in an infant with red cell pyruvate kinase deficiency. Indian Pediatr. 2007;44(4):303-5. PMID:17468529  
  34. Jay PY, Bielinska M, Erlich JM, Mannisto S, Pu WT, Heikinheimo M, Wilson DB. Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects. Dev Biol. 2007;301(2):602-14. doi:10.1016/j.ydbio.2006.09.050  PMCID:PMC1808541  PMID:17069789  
  35. Bielinska M, Seehra A, Toppari J, Heikinheimo M, Wilson DB. GATA-4 is required for sex steroidogenic cell development in the fetal mouse. Dev Dyn. 2007;236(1):203-13. doi:10.1002/dvdy.21004  PMCID:PMC2174205  PMID:17096405  
  36. Idol RA, Robledo S, Du HY, Crimmins DL, Wilson DB, Ladenson JH, Bessler M, Mason PJ. Cells depleted for RPS19, a protein associated with Diamond Blackfan Anemia, show defects in 18S ribosomal RNA synthesis and small ribosomal subunit production. Blood Cells Mol Dis. 2007;39(1):35-43. doi:10.1016/j.bcmd.2007.02.001  PMID:17376718  
  37. Huang Q, Robledo S, Wilson DB, Bessler M, Mason PJ. A four base pair insertion in exon 1 of the RPS19 gene is a common polymorphism in African-Americans. Br J Haematol. 2006;135(5):745-746. doi:10.1111/j.1365-2141.2006.06368.x  PMID:17107358  
  38. Field JJ, Mason PJ, An P, Kasai Y, McLellan M, Jaeger S, Barnes YJ, King AA, Bessler M, Wilson DB. Low frequency of telomerase RNA mutations among children with aplastic anemia or myelodysplastic syndrome. J Pediatr Hematol Oncol. 2006;28(7):450-3. doi:10.1097/01.mph.0000212952.58597.84  PMID:16825992  
  39. Anttonen M, Parviainen H, Kyrönlahti A, Bielinska M, Wilson DB, Ritvos O, Heikinheimo M. GATA-4 is a granulosa cell factor employed in inhibin-alpha activation by the TGF-beta pathway. J Mol Endocrinol. 2006;36(3):557-68. doi:10.1677/jme.1.01962  PMID:16720723  
  40. Bielinska M, Kiiveri S, Parviainen H, Mannisto S, Heikinheimo M, Wilson DB. Gonadectomy-induced adrenocortical neoplasia in the domestic ferret (Mustela putorius furo) and laboratory mouse. Vet Pathol. 2006;43(2):97-117. doi:10.1354/vp.43-2-97  PMID:16537928  
  41. Jacobsen CM, Mannisto S, Porter-Tinge S, Genova E, Parviainen H, Heikinheimo M, Adameyko II, Tevosian SG, Wilson DB. GATA-4:FOG interactions regulate gastric epithelial development in the mouse. Dev Dyn. 2005;234(2):355-62. doi:10.1002/dvdy.20552  PMID:16127717  
  42. Bielinska M, Genova E, Boime I, Parviainen H, Kiiveri S, Leppäluoto J, Rahman N, Heikinheimo M, Wilson DB. Gonadotropin-induced adrenocortical neoplasia in NU/J nude mice. Endocrinology. 2005;146(9):3975-84. doi:10.1210/en.2004-1643  PMID:15919738  
  43. Shenoy S, Grossman WJ, DiPersio J, Yu LC, Wilson D, Barnes YJ, Mohanakumar T, Rao A, Hayashi RJ. A novel reduced-intensity stem cell transplant regimen for nonmalignant disorders. Bone Marrow Transplant. 2005;35(4):345-52. doi:10.1038/sj.bmt.1704795  PMID:15592491  
  44. Bielinska M, Genova E, Boime I, Parviainen H, Kiiveri S, Rahman N, Leppäluoto J, Heikinheimo M, Wilson DB. Nude mice as a model for gonadotropin-induced adrenocortical neoplasia. Endocr Res. 2004;30(4):913-7. PMID:15666844  
  45. Divine JK, Staloch LJ, Haveri H, Jacobsen CM, Wilson DB, Heikinheimo M, Simon TC. GATA-4, GATA-5, and GATA-6 activate the rat liver fatty acid binding protein gene in concert with HNF-1alpha. Am J Physiol Gastrointest Liver Physiol. 2004;287(5):G1086-99. doi:10.1152/ajpgi.00421.2003  PMID:14715527  
  46. Ketola I, Otonkoski T, Pulkkinen MA, Niemi H, Palgi J, Jacobsen CM, Wilson DB, Heikinheimo M. Transcription factor GATA-6 is expressed in the endocrine and GATA-4 in the exocrine pancreas. Mol Cell Endocrinol. 2004;226(1-2):51-7. doi:10.1016/j.mce.2004.06.007  PMID:15489005  
  47. Rahman NA, Kiiveri S, Rivero-Müller A, Levallet J, Vierre S, Kero J, Wilson DB, Heikinheimo M, Huhtaniemi I. Adrenocortical tumorigenesis in transgenic mice expressing the inhibin alpha-subunit promoter/simian virus 40 T-antigen transgene: relationship between ectopic expression of luteinizing hormone receptor and transcription factor GATA-4. Mol Endocrinol. 2004;18(10):2553-69. doi:10.1210/me.2002-0282  PMID:15256532  
  48. Peterson RA 2nd, Kiupel M, Bielinska M, Kiiveri S, Heikinheimo M, Capen CC, Wilson DB. Transcription factor GATA-4 is a marker of anaplasia in adrenocortical neoplasms of the domestic ferret (Mustela putorius furo). Vet Pathol. 2004;41(4):446-9. doi:10.1354/vp.41-4-446  PMID:15232151  
  49. Wilson DB, Rao A, Hulbert M, Mychaliska KP, Luchtman-Jones L, Hill DA, Foglia RP. Neutropenic enterocolitis as a presenting complication of acute lymphoblastic leukemia: an unusual case marked by delayed perforation of the descending colon. J Pediatr Surg. 2004;39(7):e18-20. PMID:15213940  
  50. Grossman WJ, Wilson DB. Hypopigmentation from imatinib mesylate (Gleevec). J Pediatr Hematol Oncol. 2004;26(3):214. PMID:15125619  
  51. Wilson DB, Michalski JM, Grossman WJ, Hayashi RJ. Isolated CNS relapse following stem cell transplantation for juvenile myelomonocytic leukemia. J Pediatr Hematol Oncol. 2003;25(11):910-3. PMID:14608204  
  52. Hostetler MA, Dribben W, Wilson DB, Grossman WJ. Sudden unexplained hemolysis occurring in an infant due to presumed Loxosceles envenomation. J Emerg Med. 2003;25(3):277-82. PMID:14585455  
  53. Bielinska M, Parviainen H, Porter-Tinge SB, Kiiveri S, Genova E, Rahman N, Huhtaniemi IT, Muglia LJ, Heikinheimo M, Wilson DB. Mouse strain susceptibility to gonadectomy-induced adrenocortical tumor formation correlates with the expression of GATA4 and luteinizing hormone receptor. Endocrinology. 2003;144(9):4123-33. doi:10.1210/en.2003-0126  PMID:12933687  
  54. Wilson DB, Ivanovich J, Whelan A, Goodfellow PJ, Bessler M. Human telomerase RNA mutations and bone marrow failure. Lancet. 2003;361(9373):1993-4. doi:10.1016/S0140-6736(03)13575-1  PMID:12801777  
  55. Clabby ML, Robison TA, Quigley HF, Wilson DB, Kelly DP. Retinoid X receptor alpha represses GATA-4-mediated transcription via a retinoid-dependent interaction with the cardiac-enriched repressor FOG-2. J Biol Chem. 2003;278(8):5760-7. doi:10.1074/jbc.M208173200  PMID:12480945  
  56. Kiiveri S, Liu J, Westerholm-Ormio M, Narita N, Wilson DB, Voutilainen R, Heikinheimo M. Transcription factors GATA-4 and GATA-6 during mouse and human adrenocortical development. Endocr Res. 2002;28(4):647-50. PMID:12530677  
  57. Kiiveri S, Liu J, Westerholm-Ormio M, Narita N, Wilson DB, Voutilainen R, Heikinheimo M. Differential expression of GATA-4 and GATA-6 in fetal and adult mouse and human adrenal tissue. Endocrinology. 2002;143(8):3136-43. doi:10.1210/endo.143.8.8939  PMID:12130579  
  58. Jacobsen CM, Narita N, Bielinska M, Syder AJ, Gordon JI, Wilson DB. Genetic mosaic analysis reveals that GATA-4 is required for proper differentiation of mouse gastric epithelium. Dev Biol. 2002;241(1):34-46. doi:10.1006/dbio.2001.0424  PMID:11784093  
  59. Laitinen MP, Anttonen M, Ketola I, Wilson DB, Ritvos O, Butzow R, Heikinheimo M. Transcription factors GATA-4 and GATA-6 and a GATA family cofactor, FOG-2, are expressed in human ovary and sex cord-derived ovarian tumors. J Clin Endocrinol Metab. 2000;85(9):3476-83. doi:10.1210/jcem.85.9.6828  PMID:10999851  
  60. Siltanen S, Anttonen M, Heikkilä P, Narita N, Laitinen M, Ritvos O, Wilson DB, Heikinheimo M. Transcription factor GATA-4 is expressed in pediatric yolk sac tumors. Am J Pathol. 1999;155(6):1823-9. doi:10.1016/S0002-9440(10)65500-9  PMCID:PMC1866939  PMID:10595911  
  61. Kiiveri S, Siltanen S, Rahman N, Bielinska M, Lehto VP, Huhtaniemi IT, Muglia LJ, Wilson DB, Heikinheimo M. Reciprocal changes in the expression of transcription factors GATA-4 and GATA-6 accompany adrenocortical tumorigenesis in mice and humans. Mol Med. 1999;5(7):490-501. PMCID:PMC2230442  PMID:10449810  
  62. Bielinska M, Narita N, Wilson DB. Distinct roles for visceral endoderm during embryonic mouse development. Int J Dev Biol. 1999;43(3):183-205. PMID:10410899  
  63. Pehlivan T, Pober BR, Brueckner M, Garrett S, Slaugh R, Van Rheeden R, Wilson DB, Watson MS, Hing AV. GATA4 haploinsufficiency in patients with interstitial deletion of chromosome region 8p23.1 and congenital heart disease. Am J Med Genet. 1999;83(3):201-6. PMID:10096597  
  64. Ketola I, Rahman N, Toppari J, Bielinska M, Porter-Tinge SB, Tapanainen JS, Huhtaniemi IT, Wilson DB, Heikinheimo M. Expression and regulation of transcription factors GATA-4 and GATA-6 in developing mouse testis. Endocrinology. 1999;140(3):1470-80. doi:10.1210/endo.140.3.6587  PMID:10067876  
  65. Narita N, Bielinska M, Wilson DB. Cardiomyocyte differentiation by GATA-4-deficient embryonic stem cells. Development. 1997;124(19):3755-64. PMID:9367431  
  66. Narita N, Bielinska M, Wilson DB. Wild-type endoderm abrogates the ventral developmental defects associated with GATA-4 deficiency in the mouse. Dev Biol. 1997;189(2):270-274. doi:10.1006/dbio.1997.8684  PMID:9299119  
  67. Heikinheimo M, Ermolaeva M, Bielinska M, Rahman NA, Narita N, Huhtaniemi IT, Tapanainen JS, Wilson DB. Expression and hormonal regulation of transcription factors GATA-4 and GATA-6 in the mouse ovary. Endocrinology. 1997;138(8):3505-14. doi:10.1210/endo.138.8.5350  PMID:9231805  
  68. Bielinska M, Wilson DB. Induction of yolk sac endoderm in GATA-4-deficient embryoid bodies by retinoic acid. Mech Dev. 1997;65(1-2):43-54. PMID:9256344  
  69. Bielinska M, Narita N, Heikinheimo M, Porter SB, Wilson DB. Erythropoiesis and vasculogenesis in embryoid bodies lacking visceral yolk sac endoderm. Blood. 1996;88(10):3720-30. PMID:8916936  
  70. Goyal RK, McEvoy L, Wilson DB. Hodgkin disease after renal transplantation in childhood. J Pediatr Hematol Oncol. 1996;18(4):392-5. PMID:8888750  
  71. Narita N, Heikinheimo M, Bielinska M, White RA, Wilson DB. The gene for transcription factor GATA-6 resides on mouse chromosome 18 and is expressed in myocardium and vascular smooth muscle. Genomics. 1996;36(2):345-8. doi:10.1006/geno.1996.0472  PMID:8812463  
  72. Soudais C, Bielinska M, Heikinheimo M, MacArthur CA, Narita N, Saffitz JE, Simon MC, Leiden JM, Wilson DB. Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro. Development. 1995;121(11):3877-88. PMID:8582296  
  73. White RA, Dowler LL, Pasztor LM, Gatson LL, Adkison LR, Angeloni SV, Wilson DB. Assignment of the transcription factor GATA4 gene to human chromosome 8 and mouse chromosome 14: Gata4 is a candidate gene for Ds (disorganization). Genomics. 1995;27(1):20-6. doi:10.1006/geno.1995.1003  PMID:7665171  
  74. Bielinska M, Wilson DB. Regulation of J6 gene expression by transcription factor GATA-4. Biochem J. 1995;307 ( Pt 1):183-9. PMCID:PMC1136761  PMID:7717974  
  75. Ball RH, Picus D, Goyal RK, Wilson DB, Rader JS. Ovarian artery pseudoaneurysm: diagnosis by Doppler sonography and treatment with transcatheter embolization. J Ultrasound Med. 1995;14(3):250-2. PMID:7760472  
  76. Ip HS, Wilson DB, Heikinheimo M, Tang Z, Ting CN, Simon MC, Leiden JM, Parmacek MS. The GATA-4 transcription factor transactivates the cardiac muscle-specific troponin C promoter-enhancer in nonmuscle cells. Mol Cell Biol. 1994;14(11):7517-26. PMCID:PMC359288  PMID:7935467  
  77. Heikinheimo M, Lawshé A, Shackleford GM, Wilson DB, MacArthur CA. Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system. Mech Dev. 1994;48(2):129-38. PMID:7873403  
  78. Heikinheimo M, Scandrett JM, Wilson DB. Localization of transcription factor GATA-4 to regions of the mouse embryo involved in cardiac development. Dev Biol. 1994;164(2):361-73. doi:10.1006/dbio.1994.1206  PMID:8045339  
  79. Arceci RJ, King AA, Simon MC, Orkin SH, Wilson DB. Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol Cell Biol. 1993;13(4):2235-46. PMCID:PMC359544  PMID:8455608  
  80. Wilson DB, Wilson MP. Identification and subcellular localization of human rab5b, a new member of the ras-related superfamily of GTPases. J Clin Invest. 1992;89(3):996-1005. doi:10.1172/JCI115683  PMCID:PMC442949  PMID:1541686  
  81. Dorfman DM, Wilson DB, Bruns GA, Orkin SH. Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells. J Biol Chem. 1992;267(2):1279-85. PMID:1370462  
  82. Wilson DB, Dorfman DM, Orkin SH. A nonerythroid GATA-binding protein is required for function of the human preproendothelin-1 promoter in endothelial cells. Mol Cell Biol. 1990;10(9):4854-62. PMCID:PMC361096  PMID:2388628  
  83. Connolly TM, Wilson DB, Bross TE, Majerus PW. Isolation and characterization of the inositol cyclic phosphate products of phosphoinositide cleavage by phospholipase C. Metabolism in cell-free extracts. J Biol Chem. 1986;261(1):122-6. PMID:3001044  
  84. Wilson DB, Connolly TM, Bross TE, Majerus PW, Sherman WR, Tyler AN, Rubin LJ, Brown JE. Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells. J Biol Chem. 1985;260(25):13496-501. PMID:2997167  
  85. Auchus RJ, Wilson DB, Covey DF, Majerus PW. The 5-hydroxyl of myo-inositol is essential for uptake into HSDM1C1 mouse fibrosarcoma cells. Biochem Biophys Res Commun. 1985;130(3):1139-46. PMID:4026861  
  86. Wilson DB, Bross TE, Sherman WR, Berger RA, Majerus PW. Inositol cyclic phosphates are produced by cleavage of phosphatidylphosphoinositols (polyphosphoinositides) with purified sheep seminal vesicle phospholipase C enzymes. Proc Natl Acad Sci U S A. 1985;82(12):4013-7. PMCID:PMC397924  PMID:2987959  
  87. Wilson DB, Neufeld EJ, Majerus PW. Phosphoinositide interconversion in thrombin-stimulated human platelets. J Biol Chem. 1985;260(2):1046-51. PMID:2981829  
  88. Wilson DB, Bross TE, Hofmann SL, Majerus PW. Hydrolysis of polyphosphoinositides by purified sheep seminal vesicle phospholipase C enzymes. J Biol Chem. 1984;259(19):11718-24. PMID:6090445  
  89. Wilson DB, Salem HH, Mruk JS, Maruyama I, Majerus PW. Biosynthesis of coagulation Factor V by a human hepatocellular carcinoma cell line. J Clin Invest. 1984;73(3):654-8. doi:10.1172/JCI111256  PMCID:PMC425065  PMID:6200498  
  90. Neufeld EJ, Wilson DB, Sprecher H, Majerus PW. High affinity esterification of eicosanoid precursor fatty acids by platelets. J Clin Invest. 1983;72(1):214-20. PMCID:PMC1129176  PMID:6308046  
  91. Wilson DB, Prescott SM, Majerus PW. Discovery of an arachidonoyl coenzyme A synthetase in human platelets. J Biol Chem. 1982;257(7):3510-5. PMID:7061494  
  92. Wilson DB, Ellsworth JL, Jackson RL. Net transfer of phosphatidylcholine from plasma low density lipoproteins to sphingomyelin-apolipoprotein A-II complexes by bovine liver and human plasma phospholipid exchange proteins. Biochim Biophys Acta. 1980;620(3):550-61. PMID:7236658  
  93. Jackson RL, Glueck CJ. Exchange of phospholipids between unilamellar vesicles of 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine and plasma very low density lipoproteins. Biochim Biophys Acta. 1979;557(1):79-85. PMID:232989  
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