Hematology and Oncology | Fellowship | Publications

  1. Anim SO, Strunk RC, DeBaun MR. Patient Factors associated with abnormal lung function in children with sickle cell disease. Pediatric Blood & Cancer, Volume 58, Issue 7, 1 July 2012, 1014–1097.
  2. Barone A and Rubin JB. Opportunities and challenges for successful use of bevacizumab in pediatrics. Front. Oncol., 29 April 2013. 3:92. Published online 2013 April 29. PMCID: PMC3638307
  3. Blunt AG, Lawshe A, Cunningham ML, et al: Overlapping expression and redundant activation of mesenchymal fibroblast growth factor (FGF) receptors by alternatively spliced FGF-8 ligands. Journal of Biological Chemistry 272:3733-8, 1997.
  4. Boudreaux JM, Towler DA: Synergistic induction of osteocalcin gene expression: identification of a bipartite element conferring fibroblast growth factor 2 and cyclic AMP responsiveness in the rat osteocalcin promoter. Journal of Biological Chemistry 271:7508-15, 1996.
  5. Brandt JM, Djouadi F, Kelly DP: Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha. Journal of Biological Chemistry 273:23786-92, 1998.
  6. Celik H, Mallaney C, Kothari A, Ostrander EL, Eultgen E, Martens A, Miller CA, Hundal J, Klco JM, Challen GA. Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation. Blood. 2015 Jan 22;125(4):619-28. PMID:25416276.
  7. Choi J, Cooper ML, Ziga ED, Ritchey J, Dipersio JF. Effect of Epigallocatechin-3-Gallate on Graft-versus-Host Disease. Cell Transplant. 2013 May 14.
  8. Choi J, Ziga ED, Ritchey J, Collins L, Prior JL, Cooper ML, Piwnica-Worms D, DiPersio JF. IFNγR signaling mediates alloreactive T-cell trafficking and GVHD. Blood. 2012 Nov 8;120(19):4093-103.
  9. Crawford DF, Piwnica-Worms H: The G(2) DNA damage checkpoint delays expression of genes encoding mitotic regulators. Journal of Biological Chemistry 276:37166-37177, 2001.
  10. Dean J, Hayashi S, Albert C, King A, Karzon R and Hayashi R. Hearing loss in pediatric oncology patients receiving carboplatin-containing regimens. J Ped Hem Onc, Feb 2008 30: 2.
  11. Djouadi F, Brandt JM, Weinheimer CJ, et al: The role of the peroxisome proliferator-activated receptor alpha (PPAR alpha) in the control of cardiac lipid metabolism. Prostaglandins Leukotrienes amp; Essential Fatty Acids 60:339-43,1999.
  12. Druley TE, Vallania FML, Varley KE, Knowles OL, Bonds JA, Doniger SW, Wegner DJ, Hamvas A, Cole FS, Fay JC and Mitra RD. Accurate detection and quantification of rare allelic variants from the pooled genomic DNA of 1111 individuals. Nature Methods, advanced online publication, 01 March 2009 (doi:10.1038/nmeth.1307).
  13. Druley TE. Vallania FL. Wegner DJ. Varley KE. Knowles OL. Bonds JA. Robison SW. Doniger SW. Hamvas A Cole FS. Fay JC. Mitra RD. Quantification of rare allelic variants from pooled genomic DNA. Nature Methods. 6(4):263-5,2009.
  14. Druley TE. Hayashi R. Mansur DB. Zhang QJ. Barnes Y. Trinkaus K. Witty S. Thomas T. Klein EE. DiPersio JF. Adkins D. Shenoy S. Early outcomes after allogeneic hematopoietic SCT in pediatric patients with hematologic malignancies following single fraction TBI. Bone Marrow Transplantation. 43(4):307-14, 2009 Feb.
  15. Fields, M.E., Berlin A., Hulbert, M.L., Spinella, P.C. Red blood cell storage duration and outcomes for acute chest syndrome in children and young adults with sickle cell disease. Blood 2013; 122: 2246.
  16. Fields, M. E., Wilson, D. B. "Hematology and Oncology." Washington Manual of Pediatrics, 2nd edition. Ed. White, A. J. Philadelphia: Lippincott Williams and Wilkins, 2014.
  17. Frei-Jones MJ, Rogers ZR, Buchanan GR. Vaso-occlusive episodes in older children with sickle cell disease: emergency department management and pain assessment. J Peds 2007.
  18. Frei-Jones MJ. Field JJ. DeBaun MR. Multi-modal intervention and prospective implementation of standardized sickle cell pain admission orders reduces 30-day readmission rate. Pediatric Blood.
  19. Frei-Jones MJ. Field JJ. DeBaun MR. Risk factors for hospital readmission within 30 days: a new quality measure for children with sickle cell disease.[see comment]. Pediatric Blood & Cancer. 52(4):481-5, 2009 Apr.
  20. Gauvain KM, McKinstry RC, Mukherjee P, et al: Evaluating pediatric brain tumor cellularity with diffusion-tensor imaging. AJR. American Journal of Roentgenology 177:449-54, 2001.
  21. Gomperts BN, Gong-Cooper X, Hackett BP: Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells. Journal of Cell Science 117:1329-37, 1329.
  22. Grossman WJ, Verbsky JW, Barchet W, et al: Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity 21:589-601, 2004.
  23. Grossman WJ, Verbsky JW, Tollefsen BL, et al: Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood 104:2840-8, 2004.
  24. Gru A.A., Coughlin C.C., Schapiro M.L., Lombardi M., Martin A., Bayliss S.J., Dehner L.P. (2014). Pediatric aleukemic leukemia cutis: Report of three cases and review of the literature.  Am J Dermatopathol.
  25. Hanson R.D., Hess JL, Yu BD, et al: Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development. Proceedings of the National Academy of Sciences of the United States of America 96:14372-7, 1999.
  26. Helmink BA. Bredemeyer AL. Lee BS. Huang CY. Sharma GG. Walker LM. Bednarski JJ. Lee WL. Pandita TK. Bassing CH. Sleckman BP. MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks. Journal of Experimental Medicine. 206(3):669-79, 2009 Mar16.
  27. Herman AC, Monlish DA, Romine MP, Bhatt ST, Zippel S, Schuettpelz LG. Systemic TLR2 agonist exposure regulates hematopoietic stem cells via cell-autonomous and cell-non-autonomous mechanisms. Blood Cancer J. 2016 Jun 17;6:e437. doi: 10.1038/bcj.2016.45. PMID: 27315114
  28. Herron S, Bacak SJ, King A, et al: Inadequate recognition of education resources required for high-risk students with sickle cell disease. Archives of Pediatrics & Adolescent Medicine. 157:104, 2003.
  29. Hulbert ML. Scothorn DJ. Panepinto JA. Scott JP. Buchanan GR. Sarnaik S. Fallon R. Chu JY. Wang W. Casella JF. Resar L. Berman B. Adamkiewicz T. Hsu LL. Smith-Whitley K. Mahoney D. Woods G. Watanabe M. DeBaun MR. Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: a retrospective cohort study of 137 children with sickle cell anemia Journal of Pediatrics. 149(5):710-2, 2006 Nov.
  30. Kanter J, Khan SY, Kelher M, Gore L, and Silliman CC. Oncogenic and angiogenic growth factors accumulate during routine storage of apheresis platelet concentrates. Clin Cancer Res. 15;14(12):3942-7, 2008 Jun.
  31. Kassel R, Robertson JO, Kung VL, White FV, Cluster AS, Hulbert ML, Vogel AM. Small intestinal ulcers in hemophagocytic lymphohistiocytosis presenting as acute appendicitis. Journal of Pediatric Surgery Case Reports. 2014 June; 2(6) 325-327.
  32. Kelly ME, Chan AC: Regulation of B cell function by linker proteins. Current Opinion in Immunology 12:267-75, 2000.
  33. King AA, Tang S, Ferguson KL, et al: An education program to increase teacher knowledge about sickle cell disease. Journal of School Health 75:11-4, 2005.
  34. Kothari A, Martens A, Challen GA. (2014). Clonal-level responses of functionally distinct hematopoietic stem cells to trophic factors. Exp Hematol, 42 (4), 317-327. PMCID: PMC4004685 PubMed: 24373928.
  35. Kothari A, Ngwube A, Hayashi R, Murray L, Davis J, Haut P, Loechelt BJ, Shenoy S. Hematopoietic Cell Transplantation Using Reduced-Intensity Conditioning Is Successful in Children with Hematologic Cytopenias of Genetic Origin. Biol Blood Marrow Transplant. 2015 Jul;21(7):1321-5. doi: 10.1016/j.bbmt.2015.03.019. Epub 2015 Mar 31.
  36. Kothari A, Hulbert ML, Cottrell CE, Nguyen TT. Aggressive congenital juvenile myelomonocytic leukemia associated with somatic KRAS p.G13D mutation and concurrent germline IGF1R duplication. Leuk Lymphoma. 2015 Apr; 56(4):1175-8. doi: 10.3109/10428194.2014.953152. Epub 2014 Sep 29.
  37. Link DC, Kunter G, Kasai Y, Zhao Y, Miner T, McLellan MD, Ries RE, Kapur D, Nagarajan R, Dale DC, Bolyard AA, Boxer LA, Welte K, Zeidler C, Donadieu J, Bellanné-Chantelot C, Vardiman JW, Caligiuri MA, Bloomfield CA, DiPersio JF, Tomasson MH, Graubert TA, Westervelt P, Watson M, Shannon W, Baty J, Mardis ER, Wilson RK, and Ley TJ. Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia. Blood, Sep 2007; 110: 1648 - 1655.
  38. Liu F*, Kunter G*, Krem M*, Eades W, Cain J, Tomasson M, Henninghausen L, and Link DC. G-CSF receptor mutations found in patients with severe congenital neutropenia induce hematopoietic stem self-renewal that is mediated by STAT5. JCI, 118:946-55, 2008. *These authors contributed equally to this study.
  39. Luchtman-Jones L, Broze GJ: The current status of coagulation. Annals of Medicine 27:47-52, 1995.
  40. Mallaney C, Kothari A, Martens A, Challen GA.  (2014).  Clonal-level responses of functionally distinct hematopoietic stem cells to trophic factors.  Exp Hematol, 42 (4), 317-327.  PMCID: PMC4004685  PubMed: 24373928.
  41. Mascotti DP, Rup D, Thach RE: Regulation of iron metabolism: translational effects mediated by iron, heme, and cytokines. Annual Review of Nutrition 15:239-61, 1995.
  42. Mascotti DP, Goessling LS, Rup D, et al: Effects of the ferritin open reading frame on translational induction by iron. Progress in Nucleic Acid Research & Molecular Biology 55:121-34,1996.
  43. McDonald S, Wilson DB, Pumbo E, Kulkarni S, Mason PJ, Else T, Bessler M, Ferkol T, Shenoy S. Acquired monosomy 7 myelodysplastic syndrome in a child with clinical features suggestive of dyskeratosis congenita and IMAGe association. Pediatr Blood Cancer.2010 Jan;54(1):154-7.
  44. McLemore ML, Grewal S, Liu F, et al: STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation. Immunity 14:193-204, 2001.
  45. Newberry EP, Boudreaux JM, Towler DA: The rat osteocalcin fibroblast growth factor (FGF)-responsive element: an okadaic acid-sensitive, FGF-selective transcriptional response motif. Molecular Endocrinology 10:1029-40, 1996.
  46. Porter SN, Cluster AS, Signer RA, Voigtmann J, Monlish DA, Schuettpelz LG, Magee JA. Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines. Stem Cell Reports. 2016 Jun 14;6(6):806-14. doi: 10.1016/j.stemcr.2016.04.008. Epub 2016 May 12. PMID: 27185281
  47. Rao A. Hulbert M. Wilson DB. Severe hypertriglyceridemia in an infant with red cell pyruvate kinase deficiency. Indian Pediatrics. 44(4):303-5, 2007 Apr.
  48. Rao A. Kamani N. Filipovich A. Lee SM. Davies SM. Dalal J. Shenoy S. Successful bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning. Blood.109(1):383-5, 2007 Jan 1.
  49. Rao A, Kelly M, Musselman M, Ramadas J, Grossman W and Shenoy S. Safety, efficacy and immune reconstitution after anti-CD20 monoclonal antibody for pediatric autoimmune cytopenias. Pediatric Blood and Cancer, 2007. In press.
  50. Richards MK, Liu F, Iwasaki H, et al: Pivotal role of granulocyte colony-stimulating factor in the development of progenitors in the common myeloid pathway.Blood 102:3562-8, 2003.
  51. Russler-Germain DA, Spencer DH, Young MA, Lamprecht TL, Miller CA, Fulton R, Meyer MR, Erdmann-Gilmore P, Townsend RR, Wilson RK, Ley TJ. The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers. Cancer Cell. 2014 Apr 14;25(4):442-54. doi: 10.1016/j.ccr.2014.02.010. Epub 2014 Mar 20.
  52. Saylors RL, 3rd, Sidransky D, Friedman HS, et al: Infrequent p53 gene mutations in medulloblastomas. Cancer Research 51:4721-3, 1991.
  53. Schaefer A, Jasinski M, Bessler M: High-dose cyclophosphamide does not eradicate paroxysmal nocturnal haemoglobinuria haematopoiesis in mice carrying a Piga gene mutation. British Journal of Haematology. 120:903-6,2003.
  54. Schuettpelz LG, McDonald S, Whitesell K, Desruisseau DM, Grange DK, Gurnett CA, Wilson DB. Pilocytic astrocytoma in a child with Noonan syndrome. Pediatr Blood Cancer. 2009 Dec;53(6):1147-9.
  55. Schuettpelz LG, Behrens D, Goldsmith MI, Druley TE. Severe ceftriaxone-induced hemolysis complicated by diffuse cerebral ischemia in a child with sickle cell disease. J Pediatr Hematol Oncol. 2009 Nov;31(11):870-2.
  56. Spencer DH, Young MA, Lamprecht TL, Helton NM, Fulton R, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Miller CA, Klco JM, Wilson RK, Ley TJ. Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells. Leukemia. 2015 Jun;29(6):1279-89. doi: 10.1038/leu.2015.6. Epub 2015 Jan 20.
  57. Walling EB., Benzoni N, Dornfeld J, Bhandari R,. Sisk BA, Garbutt J, Colditz G. Interventions to Improve HPV Vaccine Uptake: A Systematic Review. Pediatrics July 2016, VOLUME 138 / ISSUE 1.
  58. Wasson JC, Saylors RL, 3rd, Zeltzer P, et al: Oncogene amplification in pediatric brain tumors. Cancer Research 50:2987-90, 1990.
  59. Yamaguchi Y, Heiny ME, Shimizu N, et al: Expression of the Wilson disease gene is deficient in the Long-Evans Cinnamon rat. Biochemical Journal 301:1-4, 1994.
  60. Yamaguchi Y, Heiny ME, Suzuki M, et al: Biochemical characterization and intracellular localization of the Menkes disease protein. Proceedings of the National Academy of Sciences of the United States of America 93:14030-5, 1996.
  61. Yang E, Zha J, Jockel J, et al: Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80:285-91, 1995.
  62. Yu BD, Hanson R.D., Hess JL, et al: MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis. Proceedings of the National Academy of Sciences of the United States of America 95:10632-6, 1998.
  63. Zha J, Harada H, Yang E, et al: Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 87:619-28, 1996.
  64. Ziga ED, Druley TE, Burham CA. Herbaspirillum Species Bacteremia in a Pediatric Oncology Patient. Journal of Clinical Microbiology. Published online 2010 August 25. doi: 10.1128/JCM.01479-10. 2010 November; 48(11): 4320–4321.
Wash U School of Medicine
Children's Hospital St. Louis
Children's Discovery Institute
© 2017 by Washington University in St. Louis
One Brookings Drive, St. Louis, MO 63130