Nephrology | Renal Transplantation
The Pediatric Renal Transplant Program at St. Louis Children's Hospital is run jointly by the Section of Transplant Surgery and the Division of Pediatric Nephrology of Washington University. The program provides comprehensive evaluation, treatment, and on-going care for children with end-stage renal disease (ESKD), including cadaveric and living donor kidney transplantation.
The first pediatric renal transplant at Washington University Medical Center was performed at Barnes Hospital in 1964. The long term survival of our patient and their transplants has steadily improved since the early years of the program, with five-year survival rates of >90% for living related donors, and >80% for cadaveric donors.
Children have received transplants for end-stage renal disease due to a variety of causes, including: congenital and hereditary kidney disorders; chronic urinary tract infections; chronic glomerular and tubular diseases; toxic exposures; polycystic kidney disease; and renal disorders secondary to systemic diseases such as Systemic Lupus Erythematosus. Our referral area encompasses Southern and Eastern Missouri, Southern Illinois, and Northeast Arkansas, besides the metropolitan St. Louis area. A separate Transplant Clinic meets weekly for long-term management of pediatric kidney transplant recipients. All patients are reviewed in a multidisciplinary team meeting, to develop treatment plans as well as to evaluate new referrals.
All patients referred for kidney transplantation undergo a comprehensive evaluation, with review of their medical history, assessment of their current medical condition and ongoing problems, as well as neuropsychological and psychosocial assessments.
Wherever possible, transplantation is performed before the initiation of dialysis in the treatment of end-stage kidney disease (Pre-emptive Transplant). In addition, we have extensive experience with both cadaveric donor and living donor (related as well as unrelated) transplants.
Ongoing Research Projects
- NIH R01 support for randomized controlled trials to improve teenage adherence after kidney transplant
- NIH U01 support for prospective multi-center studies to improve post-transplant graft and patient survival and reduce morbidities
- Long-term outcome and function of pediatric renal transplant recipients
- The role of the CKD-MBD in chronic allograft nephropathy
- North American Pediatric Renal Trials and Cooperative Studies (Registries of Transplant, Dialysis and Chronic Renal Insufficiency patients)
Transplant Nurse Practitioners
- Grace Gryzlo, RN, CPNP-AC
- Michelle Nadler, RN, CPNP-AC
- Lyn Bianchi, RN, BSN, CTTC
- Kristen Jasper, RN, BSN
- Michelle Rozier, RN, BSN
- Sharon Wheeler, RN, MSN
- Jenny Young, PharmD, BCPPS
St. Louis Children's Hospital
One Children's Place
St. Louis MO 63110
(314) 454-6289 (Voice)
(314) 454-2762 (Fax)
On-Line Information Sources/Links
Information for parents and patients
Information for physicians and health care providers