Newborn Medicine | Research | Genetic Determinants

Genetic determinants of lung disease in newborns and children:

  • surfactant pathway genes that influence risk and severity of RDS
  • in vivo measurement of surfactant metabolism using stable isotopes
  • population and disease based frequency of genetic variation in surfactant genes (table)
  • role of genetics in airway inflammation

Linkage Dysequilibrium mapping (right) is used in our laboratory to evaluate the variants in Surfactant Protein B gene and other genes in the population associated with an increased risk of neonatal Respiratory Distress Syndrome. Other areas of research in our laboratory include

F. Sessions Cole, MD
Jennifer Wambach, MD

Wash U School of Medicine
Children's Hospital St. Louis
Children's Discovery Institute
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