Newborn Medicine | Research | Necrotizing Enterocolitis

Dr. Misty Good’s laboratory focuses on the cellular and molecular mechanisms involved in the development of necrotizing enterocolitis (NEC), a disease affecting the intestine of premature babies. Specifically, the Good Lab seeks to identify nutritional strategies to protect against NEC and determine the mechanisms involved in mediating the protection. In addition, a major challenge in the field of NEC research is the ability to determine which babies are at risk for NEC development, and the Good Lab is committed to identifying these high-risk infants.

Utilizing a humanized neonatal mouse model of NEC, we are interested in:

  • Determining the components of breast milk that are protective against NEC.
  • Understanding the signaling pathways that are involved in NEC development.
  • Modifying the intestinal mucosal immune response seen in NEC.
  • Modulation of the microbiota to attenuate the development of NEC.
  • Evaluating premature infants’ biological signatures and genetic susceptibility to predict the infants at risk for NEC and biomarker development.

Our goal is to apply this knowledge to design novel preventative strategies for infants at high risk for NEC development.

Misty Good, MD

Wash U School of Medicine
Children's Hospital St. Louis
Children's Discovery Institute
© 2017 by Washington University in St. Louis
One Brookings Drive, St. Louis, MO 63130