Department of Pediatrics

Education

• MD, University of Pennsylvania, 2007
• PhD, University of Pennsylvania, 2007
• BA, Summa cum laude, Washington University in St. Louis, 2000

Training

• Residency, University of California San Francisco, 2007 - 2010
• Fellowship, University of California San Francisco, 2010 - 2014

Licensure and Board Certification

• 2010Board Certification - Pediatrics
• 2016 - PresMO, Medical License
• 2016Board Certification - Pediatric Critical Care Medicine

Honors and Awards

• Rensselaer Math and Science Award, 1996
• Phi Beta Kappa, 2000
• Medical Scientist Training Program, University of Pennsylvania, 2000
• Society for Leukocyte Biology Student Conference Award, 2005
• Molecular Medicine Fellow, UCSF, 2007
• NIH Loan Repayment Program Awardee, 2012
• Pediatric Scientist Development Program, 2012 - 2015
• Melvin Grumbach Pediatric Research Award, 2014
• FASEB Conference (Cell Calcium) Travel Award, 2018

Recent Publications view all (18)

Publication Co-Authors

Ashley Steed, M.D., Ph.D.

Mary C. Dinauer, M.D., Ph.D.

Cliff J. Luke, Ph.D.

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Regina Clemens, M.D., Ph.D.

1. Li J, Kumari T, Barazia A, Jha V, Jeong SY, Olson A, Kim M, Lee BK, Manickam V, Song Z, Clemens R, Razani B, Kim J, Dinauer MC, Cho J. Neutrophil DREAM promotes neutrophil recruitment in vascular inflammation. J Exp Med. 2022;219(1). PMCID:PMC8719643  PMID:34751735 
2. Anand G, Perry AM, Cummings CL, St Raymond E, Clemens RA, Steed AL. Surface Proteins of SARS-CoV-2 Drive Airway Epithelial Cells to Induce IFN-Dependent Inflammation. J Immunol. 2021;206(12):3000-3009. PMCID:PMC8278276  PMID:34078711 
3. Leonard JM, Zhang CX, Lu L, Hoofnagle MH, Fuchs A, Clemens RA, Ghosh S, Hughes SW, Bochicchio GV, Hotchkiss R, Turnbull IR. Extrathoracic multiple trauma dysregulates neutrophil function and exacerbates pneumonia-induced lung injury. J Trauma Acute Care Surg. 2021;90(6):924-934. PMCID:PMC8932930  PMID:34016916 
4. Lebratti T, Lim YS, Cofie A, Andhey P, Jiang X, Scott J, Fabbrizi MR, Ozantürk AN, Pham C, Clemens R, Artyomov M, Dinauer M, Shin H. A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection. Elife. 2021;10. PMCID:PMC8163503  PMID:34047696 
5. Kangelaris KN, Clemens R, Fang X, Jauregui A, Liu T, Vessel K, Deiss T, Sinha P, Leligdowicz A, Liu KD, Zhuo H, Alder MN, Wong HR, Calfee CS, Lowell CA, Matthay MA. A Neutrophil Subset Defined by Intracellular Olfactomedin 4 is Associated with Mortality in Sepsis. Am J Physiol Lung Cell Mol Physiol. 2020. PMID:33355521 
6. Grimes D, Johnson R, Pashos M, Cummings C, Kang C, Sampedro GR, Tycksen E, McBride HJ, Sah R, Lowell CA, Clemens RA. ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense. Proc Natl Acad Sci U S A. 2020;117(39):24403-24414. PMCID:PMC7533673  PMID:32929002 
7. Song Z, Huang G, Chiquetto Paracatu L, Grimes D, Gu J, Luke CJ, Clemens RA, Dinauer MC. NADPH oxidase controls pulmonary neutrophil infiltration in the response to fungal cell walls by limiting LTB4. Blood. 2020;135(12):891-903. PMCID:PMC7082617  PMID:31951647 
8. Clemens RA, Lowell CA. CRAC channel regulation of innate immune cells in health and disease. Cell Calcium. 2019;78:56-65. PMID:30641250 
9. Clemens RA, Chong J, Grimes D, Hu Y, Lowell CA. STIM1 and STIM2 cooperatively regulate mouse neutrophil store operated calcium entry and cytokine production. Blood. 2017. PMID:28724541 
10. Clemens RA, Lowell CA. Store-operated calcium signaling in neutrophils. J Leukoc Biol. 2015;98(4):497-502. PMCID:PMC4763866  PMID:25714804 
11. Zhang H, Clemens RA, Liu F, Hu Y, Baba Y, Theodore P, Kurosaki T, Lowell CA. STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense. Blood. 2014;123(14):2238-49. PMCID:PMC3975260  PMID:24493668 
12. Clemens RA, Lenox LE, Kambayashi T, Bezman N, Maltzman JS, Nichols KE, Koretzky GA. Loss of SLP-76 expression within myeloid cells confers resistance to neutrophil-mediated tissue damage while maintaining effective bacterial killing. J Immunol. 2007;178(7):4606-14. PMID:17372019 
13. Sebzda E, Hibbard C, Sweeney S, Abtahian F, Bezman N, Clemens G, Maltzman JS, Cheng L, Liu F, Turner M, Tybulewicz V, Koretzky GA, Kahn ML. Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development. Dev Cell. 2006;11(3):349-61. PMID:16950126 
14. Abtahian F, Bezman N, Clemens R, Sebzda E, Cheng L, Shattil SJ, Kahn ML, Koretzky GA. Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells. Mol Cell Biol. 2006;26(18):6936-49. PMCID:PMC1592869  PMID:16943434 
15. Clemens RA, Newbrough SA, Chung EY, Gheith S, Singer AL, Koretzky GA, Peterson EJ. PRAM-1 is required for optimal integrin-dependent neutrophil function. Mol Cell Biol. 2004;24(24):10923-32. PMCID:PMC533979  PMID:15572693 
16. Newbrough SA, Mocsai A, Clemens RA, Wu JN, Silverman MA, Singer AL, Lowell CA, Koretzky GA. SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils. Immunity. 2003;19(5):761-9. PMID:14614862 
17. Locke JE, Bradbury CM, Wei SJ, Shah S, Rene LM, Clemens RA, Roti Roti J, Horikoshi N, Gius D. Indomethacin lowers the threshold thermal exposure for hyperthermic radiosensitization and heat-shock inhibition of ionizing radiation-induced activation of NF-kappaB. Int J Radiat Biol. 2002;78(6):493-502. PMID:12065054 
18. Curry HA, Clemens RA, Shah S, Bradbury CM, Botero A, Goswami P, Gius D. Heat shock inhibits radiation-induced activation of NF-kappaB via inhibition of I-kappaB kinase. J Biol Chem. 1999;274(33):23061-7. PMID:10438474