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Gary S Gottesman
gsgottesman@wustl.edu
Professor of Pediatrics, Endocrinology and Diabetes
Professor of Pediatrics, Genetics and Genomic Medicine
Genetics and Genomic Medicine
Endocrinology and Diabetes
Department of Medicine
phone: (314) 454-6051
Education
BA,
Cum Laude in General Studies
,
Harvard College
,
1982
MD,
Cum laude eruditionis causa
,
University of Michigan Medical School
,
1988
Training
Pediatric Residency, Saint Louis Children's Hospital/Washington University School of Medicine
,
1988
-
1991
Medical Genetics Clinical/Research Fellowship, Washington University School of Medicine
,
1991
-
1995
Licensure and Board Certification
1991
-
Pres
MO, Missouri Board of Registration for the Healing Arts/Licensing Body/Medical Physician & Surgeon
1991
-
Pres
American Board of Pediatrics
1996
-
Pres
American Board of Medical Genetics and Genomics
Honors and Awards
Harvard Scholarship
,
1981
- 1982
University of Michigan Medical Student Research Fellowship
,
1984
- 1984
Howard Hughes Medical Institute-National Institutes of Health Research Scholar
,
1985
- 1986
Research Award, Osteogenesis Imperfecta Foundation, National Capital Area
,
1988
- 1988
Post-graduate Research Fellowship
,
1988
- 1988
Pediatric Scientist Development Program Fellowship
,
1991
- 1994
Achievement of Excellence in Patient Care Award-Cardinal Glennon Children's Medical Center
,
2006
Recent Publications
view all (46)
Publication Co-Authors
David H. Gutmann, MD, PhD, FAAN
Marwan Shinawi, M.D.
Christopher McPherson
Kilannin Krysiak
Dorothy Katherine Grange, M.D.
Ana María Arbeláez, M.D. MSCI
Abby Hollander, M.D.
Dahir K, Dhaliwal R, Simmons J, Imel EA, Gottesman GS, Mahan JD, Prakasam G, Hoch AI, Ramesan P, Díaz-González de Ferris M.
Healthcare Transition from Pediatric- to Adult-Focused Care in X-Linked Hypophosphatemia: Review and Expert Consensus.
J Clin Endocrinol Metab
.
2021.
PMID:
34741521
Linglart A, Imel EA, Whyte MP, Portale AA, Högler W, Boot AM, Padidela R, Van't Hoff W, Gottesman GS, Chen A, Skrinar A, Roberts MS, Carpenter TO.
Sustained efficacy and safety of burosumab, a monoclonal antibody to FGF23, in children with X-linked hypophosphatemia.
J Clin Endocrinol Metab
.
2021.
PMID:
34636899
Whyte MP, May JD, McAlister WH, Burgener K, Cortez SR, Kreienkamp R, Castro O, Verzola R, Zavala AS, McPherson CC, Gottesman GS, Ericson KL, Coburn SP, Arbelaez AM.
Vitamin B
6
deficiency with normal plasma levels of pyridoxal 5'-phosphate in perinatal hypophosphatasia.
Bone
.
2021;150:116007.
PMID:
34000433
Padidela R, Whyte MP, Glorieux FH, Munns CF, Ward LM, Nilsson O, Portale AA, Simmons JH, Namba N, Cheong HI, Pitukcheewanont P, Sochett E, Högler W, Muroya K, Tanaka H, Gottesman GS, Biggin A, Perwad F, Williams A, Nixon A, Sun W, Chen A, Skrinar A, Imel EA.
Patient-Reported Outcomes from a Randomized, Active-Controlled, Open-Label, Phase 3 Trial of Burosumab Versus Conventional Therapy in Children with X-Linked Hypophosphatemia.
Calcif Tissue Int
.
2021;108
(5):
622-633.
PMCID:
PMC8064984
PMID:
33484279
Whyte MP, Aronson J, McAlister WH, Weinstein RS, Wenkert D, Clements KL, Gottesman GS, Madson KL, Stolina M, Bijanki VN, Plotkin H, Huskey M, Duan S, Mumm S.
Coalescing expansile skeletal disease: Delineation of an extraordinary osteopathy involving the IFITM5 mutation of osteogenesis imperfecta type V.
Bone
.
2021;145:115835.
PMID:
33360005
Whyte MP, Ma NS, Mumm S, Gottesman GS, McAlister WH, Nenninger AR, Bijanki VN, Ericson KL, Magnusson P.
Persistent idiopathic hyperphosphatasemia from bone alkaline phosphatase in a healthy boy.
Bone
.
2020;138:115459.
PMID:
32474245
Whyte MP, Campeau PM, McAlister WH, Roodman GD, Kurihara N, Nenninger A, Duan S, Gottesman GS, Bijanki VN, Sedighi H, Veis DJ, Mumm S.
Juvenile Paget's Disease From Heterozygous Mutation of SP7 Encoding Osterix (Specificity Protein 7, Transcription Factor SP7).
Bone
.
2020;137:115364.
PMCID:
PMC8054448
PMID:
32298837
Lin EL, Gottesman GS, McAlister WH, Bijanki VN, Mack KE, Griffin DM, Mumm S, Whyte MP.
Healing of vitamin D deficiency rickets complicating hypophosphatasia suggests a role beyond circulating mineral sufficiency for vitamin D in musculoskeletal health.
Bone
.
2020;136:115322.
PMID:
32200022
Smith PS, Gottesman GS, Zhang F, Cook F, Ramirez B, Wenkert D, Wollberg V, Huskey M, Mumm S, Whyte MP.
X-Linked Hypophosphatemia: Uniquely Mild Disease Associated With PHEX 3'-UTR Mutation c.*231A>G (A Retrospective Case-Control Study).
J Bone Miner Res
.
2020;35
(5):
920-931.
PMID:
31910300
Mumm S, Gottesman GS, Wenkert D, Campeau PM, Nenninger A, Huskey M, Bijanki VN, Veis DJ, Barnes AM, Marini JC, Stolina M, Zhang F, McAlister WH, Whyte MP.
Bruck syndrome 2 variant lacking congenital contractures and involving a novel compound heterozygous PLOD2 mutation.
Bone
.
2020;130:115047.
PMCID:
PMC6945817
PMID:
31472299
Whyte MP, McAlister WH, Zhang F, Bijanki VN, Nenninger A, Gottesman GS, Lin EL, Huskey M, Duan S, Dahir K, Mumm S.
New explanation for autosomal dominant high bone mass: Mutation of low-density lipoprotein receptor-related protein 6.
Bone
.
2019;127:228-243.
PMID:
31085352
Imel EA, Glorieux FH, Whyte MP, Munns CF, Ward LM, Nilsson O, Simmons JH, Padidela R, Namba N, Cheong HI, Pitukcheewanont P, Sochett E, Högler W, Muroya K, Tanaka H, Gottesman GS, Biggin A, Perwad F, Mao M, Chen CY, Skrinar A, San Martin J, Portale AA.
Burosumab versus conventional therapy in children with X-linked hypophosphataemia: a randomised, active-controlled, open-label, phase 3 trial.
Lancet
.
2019;393
(10189):
2416-2427.
PMCID:
PMC7179969
PMID:
31104833
Whyte MP, Carpenter TO, Gottesman GS, Mao M, Skrinar A, San Martin J, Imel EA.
Efficacy and safety of burosumab in children aged 1-4 years with X-linked hypophosphataemia: a multicentre, open-label, phase 2 trial.
Lancet Diabetes Endocrinol
.
2019;7
(3):
189-199.
PMID:
30638856
Whyte MP, Lim E, McAlister WH, Gottesman GS, Trinh L, Veis DJ, Bijanki VN, Boden MG, Nenninger A, Mumm S, Buchbinder D.
Unique Variant of NOD2 Pediatric Granulomatous Arthritis With Severe 1,25-Dihydroxyvitamin D-Mediated Hypercalcemia and Generalized Osteosclerosis.
J Bone Miner Res
.
2018;33
(11):
2071-2080.
PMCID:
PMC6636828
PMID:
29933504
Otaify GA, Whyte MP, Gottesman GS, McAlister WH, Eric Gordon J, Hollander A, Andrews MV, El-Mofty SK, Chen WS, Veis DV, Stolina M, Woo AS, Katsonis P, Lichtarge O, Zhang F, Shinawi M.
Gnathodiaphyseal dysplasia: Severe atypical presentation with novel heterozygous mutation of the anoctamin gene (ANO5).
Bone
.
2018;107:161-171.
PMCID:
PMC5987759
PMID:
29175271
Whyte MP, Griffith M, Trani L, Mumm S, Gottesman GS, McAlister WH, Krysiak K, Lesurf R, Skidmore ZL, Campbell KM, Rosman IS, Bayliss S, Bijanki VN, Nenninger A, Van Tine BA, Griffith OL, Mardis ER.
Melorheostosis: Exome sequencing of an associated dermatosis implicates postzygotic mosaicism of mutated KRAS.
Bone
.
2017;101:145-155.
PMCID:
PMC5518630
PMID:
28434888
Talasila J, Pachigolla R, Yarlagadda KVSN, Vuppala R, Grzeschik KH, Kiran K V S S, Rose CM, Gottesman GS, Urban Z.
Acromelia-oligodontia syndrome.
Clin Case Rep
.
2017;5
(6):
968-974.
PMCID:
PMC5458011
PMID:
28588849
Gottesman GS, Madson KL, McAlister WH, Nenninger A, Wenkert D, Mumm S, Whyte MP.
Auricular ossification: A newly recognized feature of osteoprotegerin-deficiency juvenile Paget disease.
Am J Med Genet A
.
2016;170A
(4):
978-85.
PMCID:
PMC5111855
PMID:
26762549
Mumm S, Huskey M, Cajic A, Wollberg V, Zhang F, Madson KL, Wenkert D, McAlister WH, Gottesman GS, Whyte MP.
PHEX 3'-UTR c.*231A>G near the polyadenylation signal is a relatively common, mild, American mutation that masquerades as sporadic or X-linked recessive hypophosphatemic rickets.
J Bone Miner Res
.
2015;30
(1):
137-43.
PMID:
25042154
Mumm S, Huskey M, Duan S, Wenkert D, Madson KL, Gottesman GS, Nenninger AR, Laxer RM, McAlister WH, Whyte MP.
Multicentric carpotarsal osteolysis syndrome is caused by only a few domain-specific mutations in MAFB, a negative regulator of RANKL-induced osteoclastogenesis.
Am J Med Genet A
.
2014;164A
(9):
2287-93.
PMCID:
PMC4505615
PMID:
24989131
Dũng VC, Tomatsu S, Montaño AM, Gottesman G, Bober MB, Mackenzie W, Maeda M, Mitchell GA, Suzuki Y, Orii T.
Mucopolysaccharidosis IVA: correlation between genotype, phenotype and keratan sulfate levels.
Mol Genet Metab
.
2013;110
(1-2):
129-38.
PMCID:
PMC3779837
PMID:
23876334
Ross LF, Saal HM, David KL, Anderson RR, American Academy of Pediatrics., American College of Medical Genetics and Genomics..
Technical report: Ethical and policy issues in genetic testing and screening of children.
Genet Med
.
2013;15
(3):
234-45.
PMID:
23429433
Otero JE, Gottesman GS, McAlister WH, Mumm S, Madson KL, Kiffer-Moreira T, Sheen C, Millán JL, Ericson KL, Whyte MP.
Severe skeletal toxicity from protracted etidronate therapy for generalized arterial calcification of infancy.
J Bone Miner Res
.
2013;28
(2):
419-30.
PMID:
22972716
Hisama FM, Lessel D, Leistritz D, Friedrich K, McBride KL, Pastore MT, Gottesman GS, Saha B, Martin GM, Kubisch C, Oshima J.
Coronary artery disease in a Werner syndrome-like form of progeria characterized by low levels of progerin, a splice variant of lamin A.
Am J Med Genet A
.
2011;155A
(12):
3002-6.
PMCID:
PMC4679285
PMID:
22065502
Bree AF, Shah MR, BCNS Colloquium Group..
Consensus statement from the first international colloquium on basal cell nevus syndrome (BCNS).
Am J Med Genet A
.
2011;155A
(9):
2091-7.
PMID:
21834049
Gottesman GS, Batanian JR.
Mystery solved: The evolution of diagnostic abilities in genetic testing.
JAAPA
.
2011;24
(1):
57-8.
PMID:
21261153
DelRosario G, Gottesman GS.
Newborn screening tests in the 21st century: what PAs need to know.
JAAPA
.
2010;23
(4):
30-5.
PMID:
20411636
Gottesman GS.
The genetics encounter: different from the typical clinic visit.
JAAPA
.
2010;23
(3):
70.
PMID:
20232731
Eddy M, Gottesman GS.
Newborn metabolic screening and related pitfalls.
Mo Med
.
2009;106
(3):
234-40.
PMID:
22641920
Montaño AM, Tomatsu S, Gottesman GS, Smith M, Orii T.
International Morquio A Registry: clinical manifestation and natural course of Morquio A disease.
J Inherit Metab Dis
.
2007;30
(2):
165-74.
PMID:
17347914
Nishioka T, Tomatsu S, Gutierrez MA, Miyamoto K, Trandafirescu GG, Lopez PL, Grubb JH, Kanai R, Kobayashi H, Yamaguchi S, Gottesman GS, Cahill R, Noguchi A, Sly WS.
Enhancement of drug delivery to bone: characterization of human tissue-nonspecific alkaline phosphatase tagged with an acidic oligopeptide.
Mol Genet Metab
.
2006;88
(3):
244-55.
PMCID:
PMC2587042
PMID:
16616566
Openo KK, Schulz JM, Vargas CA, Orton CS, Epstein MP, Schnur RE, Scaglia F, Berry GT, Gottesman GS, Ficicioglu C, Slonim AE, Schroer RJ, Yu C, Rangel VE, Keenan J, Lamance K, Fridovich-Keil JL.
Epimerase-deficiency galactosemia is not a binary condition.
Am J Hum Genet
.
2006;78
(1):
89-102.
PMCID:
PMC1380226
PMID:
16385452
Gottesman GS.
The challenges of medical genetics and the primary care practitioner.
Mo Med
.
2004;101
(2):
85-6.
PMID:
15119103
Whyte MP, Kurtzberg J, McAlister WH, Mumm S, Podgornik MN, Coburn SP, Ryan LM, Miller CR, Gottesman GS, Smith AK, Douville J, Waters-Pick B, Armstrong RD, Martin PL.
Marrow cell transplantation for infantile hypophosphatasia.
J Bone Miner Res
.
2003;18
(4):
624-36.
PMID:
12674323
Mumm S, Zhang X, Gottesman GS, McAlister WH, Whyte MP.
Preonset studies of spondyloepiphyseal dysplasia tarda caused by a novel 2-base pair deletion in SEDL encoding sedlin.
J Bone Miner Res
.
2001;16
(12):
2245-50.
PMID:
11760838
Mumm S, Christie PT, Finnegan P, Jones J, Dixon PH, Pannett AA, Harding B, Gottesman GS, Thakker RV, Whyte MP.
A five-base pair deletion in the sedlin gene causes spondyloepiphyseal dysplasia tarda in a six-generation Arkansas kindred.
J Clin Endocrinol Metab
.
2000;85
(9):
3343-7.
PMID:
10999831
Waggoner DJ, Towbin J, Gottesman G, Gutmann DH.
Clinic-based study of plexiform neurofibromas in neurofibromatosis 1.
Am J Med Genet
.
2000;92
(2):
132-5.
PMID:
10797438
Batanian JR, Huang Y, Gottesman GS, Grange DK, Blasingame AV.
Preferential involvement of the short arm in chromosome 8-derived supernumerary markers and ring as identified by chromosome arm painting.
Am J Med Genet
.
2000;90
(4):
276-82.
PMID:
10710223
Gottesman GS, Hoffmann JW, Vogler C, Chen SC.
Hypertrophic cardiomyopathy in a newborn infant.
J Pediatr
.
1999;134
(1):
114-8.
PMID:
9880462
Whyte MP, Gottesman GS, Eddy MC, McAlister WH.
X-linked recessive spondyloepiphyseal dysplasia tarda. Clinical and radiographic evolution in a 6-generation kindred and review of the literature.
Medicine (Baltimore)
.
1999;78
(1):
9-25.
PMID:
9990351
Herman TE, Chines A, McAlister WH, Gottesman GS, Eddy MC, Whyte MP.
Erratum: metachondromatosis: report of a family with facial features mildly resembling trichorhinophalangeal syndrome (Pediatr radiol (1997) 27: 436-441)
Pediatr Radiol
.
1997;27
(11):
864.
PMID:
9361046
Herman TE, Chines A, McAlister WH, Gottesman GS, Eddy MC, Whyte MP.
Metachondromatosis: report of a family with facial features mildly resembling trichorhinophalangeal syndromePediatr Radiol 1997 Nov;27(11):864.
Pediatr Radiol
.
1997;27
(5):
436-41.
PMID:
9133359
Grange DK, Gottesman GS, Lewis MB, Marini JC.
Detection of point mutations in type I collagen by RNase digestion of RNA/RNA hybrids.
Nucleic Acids Res
.
1990;18
(14):
4227-36.
PMCID:
PMC331183
PMID:
1696002
Marini JC, Grange DK, Gottesman GS, Lewis MB, Koeplin DA.
Osteogenesis imperfecta type IV. Detection of a point mutation in one alpha 1(I) collagen allele (COL1A1) by RNA/RNA hybrid analysis.
J Biol Chem
.
1989;264
(20):
11893-900.
PMID:
2745420
Marini JC, Gottesman GS, Zasloff MA.
Human and chick alpha 2(I) collagen mRNA: comparison of the 5' end in osteoblasts and fibroblasts.
Biochemistry
.
1988;27
(9):
3351-6.
PMID:
3390435
Burden SJ, DePalma RL, Gottesman GS.
Crosslinking of proteins in acetylcholine receptor-rich membranes: association between the beta-subunit and the 43 kd subsynaptic protein.
Cell
.
1983;35
(3 Pt 2):
687-92.
PMID:
6652683
Last updated: 02/16/2022
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