Department of Pediatrics

Education

• BA, Cum Laude in General Studies, Harvard College, 1982
• MD, Cum laude eruditionis causa, University of Michigan Medical School, 1988

Training

• Pediatric Residency, Saint Louis Children's Hospital/Washington University School of Medicine, 1988 - 1991
• Medical Genetics Clinical/Research Fellowship, Washington University School of Medicine, 1991 - 1995

Licensure and Board Certification

• 1991 - PresMO, Missouri Board of Registration for the Healing Arts/Licensing Body/Medical Physician & Surgeon
• 1991 - PresAmerican Board of Pediatrics
• 1996 - PresAmerican Board of Medical Genetics and Genomics

Honors and Awards

• Harvard Scholarship, 1981 - 1982
• University of Michigan Medical Student Research Fellowship, 1984 - 1984
• Howard Hughes Medical Institute-National Institutes of Health Research Scholar, 1985 - 1986
• Research Award, Osteogenesis Imperfecta Foundation, National Capital Area, 1988 - 1988
• Post-graduate Research Fellowship, 1988 - 1988
• Pediatric Scientist Development Program Fellowship, 1991 - 1994
• Achievement of Excellence in Patient Care Award-Cardinal Glennon Children's Medical Center, 2006

Recent Publications view all (46)

Publication Co-Authors

David H. Gutmann, MD, PhD, FAAN

Marwan Shinawi, M.D.

Christopher McPherson

Kilannin Krysiak

Dorothy Katherine Grange, M.D.

Ana María Arbeláez, M.D. MSCI

Abby Hollander, M.D.

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Gary S Gottesman

1. Dahir K, Dhaliwal R, Simmons J, Imel EA, Gottesman GS, Mahan JD, Prakasam G, Hoch AI, Ramesan P, Díaz-González de Ferris M. Healthcare Transition from Pediatric- to Adult-Focused Care in X-Linked Hypophosphatemia: Review and Expert Consensus. J Clin Endocrinol Metab. 2021. PMID:34741521 
2. Linglart A, Imel EA, Whyte MP, Portale AA, Högler W, Boot AM, Padidela R, Van't Hoff W, Gottesman GS, Chen A, Skrinar A, Roberts MS, Carpenter TO. Sustained efficacy and safety of burosumab, a monoclonal antibody to FGF23, in children with X-linked hypophosphatemia. J Clin Endocrinol Metab. 2021. PMID:34636899 
3. Whyte MP, May JD, McAlister WH, Burgener K, Cortez SR, Kreienkamp R, Castro O, Verzola R, Zavala AS, McPherson CC, Gottesman GS, Ericson KL, Coburn SP, Arbelaez AM. Vitamin B₆ deficiency with normal plasma levels of pyridoxal 5'-phosphate in perinatal hypophosphatasia. Bone. 2021;150:116007. PMID:34000433 
4. Padidela R, Whyte MP, Glorieux FH, Munns CF, Ward LM, Nilsson O, Portale AA, Simmons JH, Namba N, Cheong HI, Pitukcheewanont P, Sochett E, Högler W, Muroya K, Tanaka H, Gottesman GS, Biggin A, Perwad F, Williams A, Nixon A, Sun W, Chen A, Skrinar A, Imel EA. Patient-Reported Outcomes from a Randomized, Active-Controlled, Open-Label, Phase 3 Trial of Burosumab Versus Conventional Therapy in Children with X-Linked Hypophosphatemia. Calcif Tissue Int. 2021;108(5):622-633. PMCID:PMC8064984  PMID:33484279 
5. Whyte MP, Aronson J, McAlister WH, Weinstein RS, Wenkert D, Clements KL, Gottesman GS, Madson KL, Stolina M, Bijanki VN, Plotkin H, Huskey M, Duan S, Mumm S. Coalescing expansile skeletal disease: Delineation of an extraordinary osteopathy involving the IFITM5 mutation of osteogenesis imperfecta type V. Bone. 2021;145:115835. PMID:33360005 
6. Whyte MP, Ma NS, Mumm S, Gottesman GS, McAlister WH, Nenninger AR, Bijanki VN, Ericson KL, Magnusson P. Persistent idiopathic hyperphosphatasemia from bone alkaline phosphatase in a healthy boy. Bone. 2020;138:115459. PMID:32474245 
7. Whyte MP, Campeau PM, McAlister WH, Roodman GD, Kurihara N, Nenninger A, Duan S, Gottesman GS, Bijanki VN, Sedighi H, Veis DJ, Mumm S. Juvenile Paget's Disease From Heterozygous Mutation of SP7 Encoding Osterix (Specificity Protein 7, Transcription Factor SP7). Bone. 2020;137:115364. PMCID:PMC8054448  PMID:32298837 
8. Lin EL, Gottesman GS, McAlister WH, Bijanki VN, Mack KE, Griffin DM, Mumm S, Whyte MP. Healing of vitamin D deficiency rickets complicating hypophosphatasia suggests a role beyond circulating mineral sufficiency for vitamin D in musculoskeletal health. Bone. 2020;136:115322. PMID:32200022 
9. Smith PS, Gottesman GS, Zhang F, Cook F, Ramirez B, Wenkert D, Wollberg V, Huskey M, Mumm S, Whyte MP. X-Linked Hypophosphatemia: Uniquely Mild Disease Associated With PHEX 3'-UTR Mutation c.*231A>G (A Retrospective Case-Control Study). J Bone Miner Res. 2020;35(5):920-931. PMID:31910300 
10. Mumm S, Gottesman GS, Wenkert D, Campeau PM, Nenninger A, Huskey M, Bijanki VN, Veis DJ, Barnes AM, Marini JC, Stolina M, Zhang F, McAlister WH, Whyte MP. Bruck syndrome 2 variant lacking congenital contractures and involving a novel compound heterozygous PLOD2 mutation. Bone. 2020;130:115047. PMCID:PMC6945817  PMID:31472299 
11. Whyte MP, McAlister WH, Zhang F, Bijanki VN, Nenninger A, Gottesman GS, Lin EL, Huskey M, Duan S, Dahir K, Mumm S. New explanation for autosomal dominant high bone mass: Mutation of low-density lipoprotein receptor-related protein 6. Bone. 2019;127:228-243. PMID:31085352 
12. Imel EA, Glorieux FH, Whyte MP, Munns CF, Ward LM, Nilsson O, Simmons JH, Padidela R, Namba N, Cheong HI, Pitukcheewanont P, Sochett E, Högler W, Muroya K, Tanaka H, Gottesman GS, Biggin A, Perwad F, Mao M, Chen CY, Skrinar A, San Martin J, Portale AA. Burosumab versus conventional therapy in children with X-linked hypophosphataemia: a randomised, active-controlled, open-label, phase 3 trial. Lancet. 2019;393(10189):2416-2427. PMCID:PMC7179969  PMID:31104833 
13. Whyte MP, Carpenter TO, Gottesman GS, Mao M, Skrinar A, San Martin J, Imel EA. Efficacy and safety of burosumab in children aged 1-4 years with X-linked hypophosphataemia: a multicentre, open-label, phase 2 trial. Lancet Diabetes Endocrinol. 2019;7(3):189-199. PMID:30638856 
14. Whyte MP, Lim E, McAlister WH, Gottesman GS, Trinh L, Veis DJ, Bijanki VN, Boden MG, Nenninger A, Mumm S, Buchbinder D. Unique Variant of NOD2 Pediatric Granulomatous Arthritis With Severe 1,25-Dihydroxyvitamin D-Mediated Hypercalcemia and Generalized Osteosclerosis. J Bone Miner Res. 2018;33(11):2071-2080. PMCID:PMC6636828  PMID:29933504 
15. Otaify GA, Whyte MP, Gottesman GS, McAlister WH, Eric Gordon J, Hollander A, Andrews MV, El-Mofty SK, Chen WS, Veis DV, Stolina M, Woo AS, Katsonis P, Lichtarge O, Zhang F, Shinawi M. Gnathodiaphyseal dysplasia: Severe atypical presentation with novel heterozygous mutation of the anoctamin gene (ANO5). Bone. 2018;107:161-171. PMCID:PMC5987759  PMID:29175271 
16. Whyte MP, Griffith M, Trani L, Mumm S, Gottesman GS, McAlister WH, Krysiak K, Lesurf R, Skidmore ZL, Campbell KM, Rosman IS, Bayliss S, Bijanki VN, Nenninger A, Van Tine BA, Griffith OL, Mardis ER. Melorheostosis: Exome sequencing of an associated dermatosis implicates postzygotic mosaicism of mutated KRAS. Bone. 2017;101:145-155. PMCID:PMC5518630  PMID:28434888 
17. Talasila J, Pachigolla R, Yarlagadda KVSN, Vuppala R, Grzeschik KH, Kiran K V S S, Rose CM, Gottesman GS, Urban Z. Acromelia-oligodontia syndrome. Clin Case Rep. 2017;5(6):968-974. PMCID:PMC5458011  PMID:28588849 
18. Gottesman GS, Madson KL, McAlister WH, Nenninger A, Wenkert D, Mumm S, Whyte MP. Auricular ossification: A newly recognized feature of osteoprotegerin-deficiency juvenile Paget disease. Am J Med Genet A. 2016;170A(4):978-85. PMCID:PMC5111855  PMID:26762549 
19. Mumm S, Huskey M, Cajic A, Wollberg V, Zhang F, Madson KL, Wenkert D, McAlister WH, Gottesman GS, Whyte MP. PHEX 3'-UTR c.*231A>G near the polyadenylation signal is a relatively common, mild, American mutation that masquerades as sporadic or X-linked recessive hypophosphatemic rickets. J Bone Miner Res. 2015;30(1):137-43. PMID:25042154 
20. Mumm S, Huskey M, Duan S, Wenkert D, Madson KL, Gottesman GS, Nenninger AR, Laxer RM, McAlister WH, Whyte MP. Multicentric carpotarsal osteolysis syndrome is caused by only a few domain-specific mutations in MAFB, a negative regulator of RANKL-induced osteoclastogenesis. Am J Med Genet A. 2014;164A(9):2287-93. PMCID:PMC4505615  PMID:24989131 
21. Dũng VC, Tomatsu S, Montaño AM, Gottesman G, Bober MB, Mackenzie W, Maeda M, Mitchell GA, Suzuki Y, Orii T. Mucopolysaccharidosis IVA: correlation between genotype, phenotype and keratan sulfate levels. Mol Genet Metab. 2013;110(1-2):129-38. PMCID:PMC3779837  PMID:23876334 
22. Ross LF, Saal HM, David KL, Anderson RR, American Academy of Pediatrics., American College of Medical Genetics and Genomics.. Technical report: Ethical and policy issues in genetic testing and screening of children. Genet Med. 2013;15(3):234-45. PMID:23429433 
23. Otero JE, Gottesman GS, McAlister WH, Mumm S, Madson KL, Kiffer-Moreira T, Sheen C, Millán JL, Ericson KL, Whyte MP. Severe skeletal toxicity from protracted etidronate therapy for generalized arterial calcification of infancy. J Bone Miner Res. 2013;28(2):419-30. PMID:22972716 
24. Hisama FM, Lessel D, Leistritz D, Friedrich K, McBride KL, Pastore MT, Gottesman GS, Saha B, Martin GM, Kubisch C, Oshima J. Coronary artery disease in a Werner syndrome-like form of progeria characterized by low levels of progerin, a splice variant of lamin A. Am J Med Genet A. 2011;155A(12):3002-6. PMCID:PMC4679285  PMID:22065502 
25. Bree AF, Shah MR, BCNS Colloquium Group.. Consensus statement from the first international colloquium on basal cell nevus syndrome (BCNS). Am J Med Genet A. 2011;155A(9):2091-7. PMID:21834049 
26. Gottesman GS, Batanian JR. Mystery solved: The evolution of diagnostic abilities in genetic testing. JAAPA. 2011;24(1):57-8. PMID:21261153 
27. DelRosario G, Gottesman GS. Newborn screening tests in the 21st century: what PAs need to know. JAAPA. 2010;23(4):30-5. PMID:20411636 
28. Gottesman GS. The genetics encounter: different from the typical clinic visit. JAAPA. 2010;23(3):70. PMID:20232731 
29. Eddy M, Gottesman GS. Newborn metabolic screening and related pitfalls. Mo Med. 2009;106(3):234-40. PMID:22641920 
30. Montaño AM, Tomatsu S, Gottesman GS, Smith M, Orii T. International Morquio A Registry: clinical manifestation and natural course of Morquio A disease. J Inherit Metab Dis. 2007;30(2):165-74. PMID:17347914 
31. Nishioka T, Tomatsu S, Gutierrez MA, Miyamoto K, Trandafirescu GG, Lopez PL, Grubb JH, Kanai R, Kobayashi H, Yamaguchi S, Gottesman GS, Cahill R, Noguchi A, Sly WS. Enhancement of drug delivery to bone: characterization of human tissue-nonspecific alkaline phosphatase tagged with an acidic oligopeptide. Mol Genet Metab. 2006;88(3):244-55. PMCID:PMC2587042  PMID:16616566 
32. Openo KK, Schulz JM, Vargas CA, Orton CS, Epstein MP, Schnur RE, Scaglia F, Berry GT, Gottesman GS, Ficicioglu C, Slonim AE, Schroer RJ, Yu C, Rangel VE, Keenan J, Lamance K, Fridovich-Keil JL. Epimerase-deficiency galactosemia is not a binary condition. Am J Hum Genet. 2006;78(1):89-102. PMCID:PMC1380226  PMID:16385452 
33. Gottesman GS. The challenges of medical genetics and the primary care practitioner. Mo Med. 2004;101(2):85-6. PMID:15119103 
34. Whyte MP, Kurtzberg J, McAlister WH, Mumm S, Podgornik MN, Coburn SP, Ryan LM, Miller CR, Gottesman GS, Smith AK, Douville J, Waters-Pick B, Armstrong RD, Martin PL. Marrow cell transplantation for infantile hypophosphatasia. J Bone Miner Res. 2003;18(4):624-36. PMID:12674323 
35. Mumm S, Zhang X, Gottesman GS, McAlister WH, Whyte MP. Preonset studies of spondyloepiphyseal dysplasia tarda caused by a novel 2-base pair deletion in SEDL encoding sedlin. J Bone Miner Res. 2001;16(12):2245-50. PMID:11760838 
36. Mumm S, Christie PT, Finnegan P, Jones J, Dixon PH, Pannett AA, Harding B, Gottesman GS, Thakker RV, Whyte MP. A five-base pair deletion in the sedlin gene causes spondyloepiphyseal dysplasia tarda in a six-generation Arkansas kindred. J Clin Endocrinol Metab. 2000;85(9):3343-7. PMID:10999831 
37. Waggoner DJ, Towbin J, Gottesman G, Gutmann DH. Clinic-based study of plexiform neurofibromas in neurofibromatosis 1. Am J Med Genet. 2000;92(2):132-5. PMID:10797438 
38. Batanian JR, Huang Y, Gottesman GS, Grange DK, Blasingame AV. Preferential involvement of the short arm in chromosome 8-derived supernumerary markers and ring as identified by chromosome arm painting. Am J Med Genet. 2000;90(4):276-82. PMID:10710223 
39. Gottesman GS, Hoffmann JW, Vogler C, Chen SC. Hypertrophic cardiomyopathy in a newborn infant. J Pediatr. 1999;134(1):114-8. PMID:9880462 
40. Whyte MP, Gottesman GS, Eddy MC, McAlister WH. X-linked recessive spondyloepiphyseal dysplasia tarda. Clinical and radiographic evolution in a 6-generation kindred and review of the literature. Medicine (Baltimore). 1999;78(1):9-25. PMID:9990351 
41. Herman TE, Chines A, McAlister WH, Gottesman GS, Eddy MC, Whyte MP. Erratum: metachondromatosis: report of a family with facial features mildly resembling trichorhinophalangeal syndrome (Pediatr radiol (1997) 27: 436-441) Pediatr Radiol. 1997;27(11):864. PMID:9361046 
42. Herman TE, Chines A, McAlister WH, Gottesman GS, Eddy MC, Whyte MP. Metachondromatosis: report of a family with facial features mildly resembling trichorhinophalangeal syndromePediatr Radiol 1997 Nov;27(11):864. Pediatr Radiol. 1997;27(5):436-41. PMID:9133359 
43. Grange DK, Gottesman GS, Lewis MB, Marini JC. Detection of point mutations in type I collagen by RNase digestion of RNA/RNA hybrids. Nucleic Acids Res. 1990;18(14):4227-36. PMCID:PMC331183  PMID:1696002 
44. Marini JC, Grange DK, Gottesman GS, Lewis MB, Koeplin DA. Osteogenesis imperfecta type IV. Detection of a point mutation in one alpha 1(I) collagen allele (COL1A1) by RNA/RNA hybrid analysis. J Biol Chem. 1989;264(20):11893-900. PMID:2745420 
45. Marini JC, Gottesman GS, Zasloff MA. Human and chick alpha 2(I) collagen mRNA: comparison of the 5' end in osteoblasts and fibroblasts. Biochemistry. 1988;27(9):3351-6. PMID:3390435 
46. Burden SJ, DePalma RL, Gottesman GS. Crosslinking of proteins in acetylcholine receptor-rich membranes: association between the beta-subunit and the 43 kd subsynaptic protein. Cell. 1983;35(3 Pt 2):687-92. PMID:6652683