Ana María Arbeláez, M.D. MSCI

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Researcher, Patient Oriented Research Unit
ICTS TL1 Predoctoral Clinical Research Program
Division Chief, School of Medicine
Professor of Pediatrics, Endocrinology and Diabetes
Endocrinology and Diabetes

phone: (314) 454-6051

Clinical Interests

Dr. Arbelaez evaluates children with a variety of Pediatric and Adolescent Diabetes and Endocrine disorders at St. Louis Children's Hospital: hypoglycemia and metabolism disorders, growth disorders, thyroid disorders, disorders of pituitary and adrenal gland, disorders of puberty and endocrine disorders in patients with cystic fibrosis.

Dr. Arbelaez is the Co-Director for the Predoctoral Interdisciplinary Clinical Research Training Program at Washington University in St Louis. In her research laboratory, she studies the effects of glycemic extremes (hypoglycemia and hyperglycemia)and glucose deprivation (malnutrition) on brain glucose metabolism, neurodevelopment and glucose counterregulation. She has experience conducting interdisciplinary human studies of glucose counterregulation using neuroimaging methodologies, such as PET and MRI and in the management of multidisciplinary domestic and international research teams. She has been part of multicenter studies such as the TODAY Study and DirecNet Study. Dr. Arbelaez’s work has been funded by both federal and non-federal sources, including: the NIH, The Robert Wood Johnson Foundation, The Children’s Discovery Institute, The Institute of Clinical and Translational Sciences, and the Washington University Mallinckrodt Institute of Radiology. She is a member of the American Society for Pediatric Research. Her work has contributed to our understanding of the brain-hormone interactions during the cascade of physiological responses that occur across various levels of glycemia and how these are altered in vivo in humans.


  • MD, Universidad del Valle School of Medicine1997
  • MS, Washington University2011


  • Biology, Universidad del Valle School of Science1989 - 1990
  • Medicine and Surgery, Universidad Libre1990 - 1991
  • M.D., Universidad del Valle School of Medicine1991 - 1997
  • Medical training program for Latin America, Jackson Memorial Hospital, University of Miami1996 - 1997
  • Pediatric Residency, St. Louis Children’s Hospital1999 - 2002
  • Pediatric Endocrinology Fellowship , Washington University School of Medicine2002 - 2005

Licensure and Board Certification

  • 2003 - 2013Diplomat, American Board of General Pediatrics
  • 2005 - 2021MO, Missouri State Medical License
  • 2011 - 2021Diplomat, American Board of Pediatric Endocrinology

Honors and Awards

  • “PTA Medal” Best Baccalaureate Student at Colegio Colombo Britanico1983
  • Universidad Libre, Best Student School of Medicine1991 - 1992
  • Medical Student of the Year at Universidad del Valle1996
  • Hospital Infantil Club Noel, Cali. Outstanding Physician Award1997
  • Endocrine Society Travel Award2001
  • Barnes Jewish Hospital Caring Spirit Award2002
  • James P. Keating, M.D. Outstanding Pediatric Resident Award2002
  • Missouri Chapter, American Academy of Pediatrics Outstanding Resident Award2002
  • Outstanding Fellow Teaching Award2003
  • Endocrine Society Travel Award2005
  • Scholar, Mentored Training Program in Clinical Investigation (K30 Program)2007 - 2008
  • Scholar, KL2 Multidisciplinary Clinical Research Career Development Program2008 - 2011
  • Scholar, Child Health Research Center2010
  • Nominated to the Washington University American Association of Medical Colleges Humanism in Medicine Award2010
  • Scholar Harold Amos Medical Faculty Development Program/ Robert Wood Johnson Foundation2011 - Pres
  • Elected Member of American Society for Pediatric Research2013
  • Washington University Teresa Vietti Fellow Award2013
  • Best Doctor St Louis Magazine2015 - Pres
  • Best Doctor St. Louis Magazine2016 - Pres
  • Alpha Omega Alpha Honor Medical Society2017 - Pres
  • Best Doctor St Louis Magazine2017 - Pres
  • ADA President's Abstract Award2019

Recent Publications view all (63)

Publication Co-Authors

  1. Testing an Automated Approach to Identify Variation in Outcomes among Children with Type 1 Diabetes across Multiple Sites. ;7:e602. Pediatr Qual Saf. 2022;7(5):p e602. doi:10.1097/pq9.0000000000000602  
  2. A Pilot randomized trial to examine effects of a hybrid closed-loop insulin delivery system on neurodevelopmental and cognitive outcomes in adolescents with type 1 diabetes. Nat Commun. 2022;13(1):4940. PMCID:PMC9427757  PMID:36042217 
  3. Association Between Endocrine Disorders and Severe COVID-19 Disease in Pediatric Patients. Horm Res Paediatr. 2022. PMCID:PMC9393781  PMID:35417912 
  4. Comparison of Bioelectrical Impedance Analysis with DXA in Adolescents with Cystic Fibrosis Before and After a Resistance Training Intervention Int. J. Environ. Res. Public Health. 2022;19(7). doi:  
  5. Comparison of Bioelectrical Impedance Analysis with DXA in Adolescents with Cystic Fibrosis before and after a Resistance Training Intervention. Int J Environ Res Public Health. 2022;19(7). PMCID:PMC8997924  PMID:35409718 
  6. Feasibility and Efficacy of Telehealth-Based Resistance Exercise Training in Adolescents with Cystic Fibrosis and Glucose Intolerance. Int J Environ Res Public Health. 2022;19(6). PMCID:PMC8950531  PMID:35328985 
  7. Rates of adrenal insufficiency using a monoclonal vs. polyclonal cortisol assay. J Pediatr Endocrinol Metab. 2021. PMID:34890170 
  8. The association between body composition, leptin levels and glucose dysregulation in youth with cystic fibrosis. J Cyst Fibros. 2021;20(5):796-802. PMID:34183284 
  9. Blood leukocytes recapitulate diabetogenic peptide-MHC-II complexes displayed in the pancreatic islets. J Exp Med. 2021;218(6). PMCID:PMC8034384  PMID:33822842 
  10. Vitamin B6 deficiency with normal plasma levels of pyridoxal 5'-phosphate in perinatal hypophosphatasia. Bone. 2021;150:116007. PMID:34000433 
  11. Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study. Diabetes Care. 2021;44(4):983-992. PMCID:PMC7985430  PMID:33568403 
  12. Brain Function Differences in Children With Type 1 Diabetes: A Functional MRI Study of Working Memory. Diabetes. 2020;69(8):1770-1778. PMCID:PMC7372069  PMID:32471809 
  13. Portable, field-based neuroimaging using high-density diffuse optical tomography. Neuroimage. 2020;215:116541. PMID:31987995 
  14. Executive task-based brain function in children with type 1 diabetes: An observational study. PLoS Med. 2019;16(12):e1002979. PMCID:PMC6901178  PMID:31815939 
  15. Impact of Early Diabetic Ketoacidosis on the Developing Brain. Diabetes Care. 2019;42(3):443-449. PMCID:PMC6385695  PMID:30573652 
  16. Inherited Deletion of 1q, Hyperparathyroidism, and Signs of Y-Chromosomal Influence in a Patient with Turner Syndrome. J Clin Res Pediatr Endocrinol. 2019. PMID:29739732 
  17. Persistence of abnormalities in white matter in children with type 1 diabetes. Diabetologia. 2018;61(7):1538-1547. PMCID:PMC5991628  PMID:29654376 
  18. Quantitative positron emission tomography reveals regional differences in aerobic glycolysis within the human brain. J Cereb Blood Flow Metab. 2018;271678X18767005. PMID:29569986 
  19. Dissociation Between Hormonal Counterregulatory Responses and Cerebral Glucose Metabolism During Hypoglycemia. Diabetes. 2017;66(12):2964-2972. PMCID:PMC5697948  PMID:28970283 
  20. Hypoglycemia during moderate intensity exercise reduces counterregulatory responses to subsequent hypoglycemia. Physiol Rep. 2016;4(17). PMCID:PMC5027337  PMID:27597762 
  21. Severity of clinical presentation in youth with type 1 diabetes is associated with differences in brain structure. Pediatr Diabetes. 2016. PMID:27488913 
  22. Associations of the Levels of C4d-bearing Reticulocytes and High-avidity Anti-dsDNA Antibodies with Disease Activity in Systemic Lupus Erythematosus. J Rheumatol. 2016. PMID:27134246 
  23. Academic abilities and glycaemic control in children and young people with Type 1 diabetes mellitus. Diabet Med. 2016;33(5):668-73. PMCID:PMC4713372  PMID:26173465 
  24. Persistently high glucose levels in young children with type 1 diabetes. Pediatr Diabetes. 2016;17(2):93-100. PMCID:PMC4465416  PMID:25496062 
  25. Longitudinal Evaluation of Cognitive Functioning in Young Children with Type 1 Diabetes over 18 Months. J Int Neuropsychol Soc. 2016;22(3):293-302. PMCID:PMC4856439  PMID:26786245 
  26. Correction: Insulin, Central Dopamine D2 Receptors, and Monetary Reward Discounting in Obesity. PLoS One. 2016;11(1):e0147063. PMCID:PMC4713421  PMID:26744894 
  27. Clinical presentation and memory function in youth with type 1 diabetes. Pediatr Diabetes. 2015. PMCID:PMC4803626  PMID:26377697 
  28. Airway Obstruction Worsens in Young Adults with Asthma Who Become Obese. J Allergy Clin Immunol Pract. 2015;3(5):765-71.e2. PMCID:PMC4568157  PMID:26164807 
  29. Longitudinal assessment of neuroanatomical and cognitive differences in young children with type 1 diabetes: association with hyperglycemia. Diabetes. 2015;64(5):1770-9. PMCID:PMC4407847  PMID:25488901 
  30. Markers of cardiovascular risk, insulin resistance, and ventricular dysfunction and remodeling in obese adolescents. J Pediatr. 2015;166(3):660-5. PMCID:PMC4344883  PMID:25556013 
  31. Insulin, Central Dopamine D2 Receptors, and Monetary Reward Discounting in Obesity. PLoS One. 2015;10(7):e0133621. PMCID:PMC4507849  PMID:26192187 
  32. Skin and adhesive issues with continuous glucose monitors: a sticky situation. J Diabetes Sci Technol. 2014;8(4):745-51. PMCID:PMC4764227  PMID:24876416 
  33. Evolution of abnormal plasma glucagon responses to mixed-meal feedings in youth with type 1 diabetes during the first 2 years after diagnosis. Diabetes Care. 2014;37(6):1741-4. doi:10.2337/dc13-2612  PMCID:PMC4030093  PMID:24696460 
  34. Coeliac disease presenting as severe hypoglycaemia in youth with type 1 diabetes. Diabet Med. 2014. doi:10.1111/dme.12488  PMID:24805141 
  35. Blunted glucagon but not epinephrine responses to hypoglycemia occurs in youth with less than 1 yr duration of type 1 diabetes mellitus. Pediatr Diabetes. 2014;15(2):127-34. doi:10.1111/pedi.12070  PMCID:PMC3858506  PMID:23992543 
  36. Cognitive functioning in young children with type 1 diabetes. J Int Neuropsychol Soc. 2014;20(2):238-47. PMCID:PMC4123061  PMID:24512675 
  37. Neuroanatomical correlates of dysglycemia in young children with type 1 diabetes. Diabetes. 2014;63(1):343-53. PMCID:PMC3868050  PMID:24170697 
  38. Glycemic extremes in youth with T1DM: the structural and functional integrity of the developing brain. Pediatr Diabetes. 2013;14(8):541-53. doi:10.1111/pedi.12088  PMCID:PMC3857606  PMID:24119040 
  39. Effectiveness of early intensive therapy on β-cell preservation in type 1 diabetes. Diabetes Care. 2013;36(12):4030-5. PMCID:PMC3836135  PMID:24130350 
  40. Lactate and the mechanism of hypoglycemia-associated autonomic failure in diabetes. Diabetes. 2013;62(12):3999-4001. doi:10.2337/db13-1360  PMCID:PMC3837063  PMID:24264400 
  41. A comparison of D2 receptor specific binding in obese and normal-weight individuals using PET with (N-[(11)C]methyl)benperidol. Synapse. 2013;67(11):748-56. doi:10.1002/syn.21680  PMCID:PMC3778147  PMID:23650017 
  42. The effects of inpatient hybrid closed-loop therapy initiated within 1 week of type 1 diabetes diagnosis. Diabetes Technol Ther. 2013;15(5):401-8. PMCID:PMC3643224  PMID:23570538 
  43. Hypoglycaemia-induced changes in regional brain volume and memory function. Diabet Med. 2013;30(4):e151-6. doi:10.1111/dme.12135  PMCID:PMC3651610  PMID:23330574 
  44. White matter microstructural integrity in youth with type 1 diabetes. Diabetes. 2013;62(2):581-9. doi:10.2337/db12-0696  PMCID:PMC3554385  PMID:23139349 
  45. Lack of association between residual insulin production and glucagon response to hypoglycemia in youth with short duration of type 1 diabetes. Diabetes Care. 2013. doi:10.2337/dc12-1697  PMID:23288858 
  46. Comparison of regional cerebral blood flow responses to hypoglycemia using pulsed arterial spin labeling and positron emission tomography. PLoS One. 2013;8(3):e60085. PMCID:PMC3610825  PMID:23555895 
  47. Noninvasive estimation of the arterial input function in positron emission tomography imaging of cerebral blood flow. J Cereb Blood Flow Metab. 2013;33(1):115-21. doi:10.1038/jcbfm.2012.143  PMCID:PMC3597366  PMID:23072748 
  48. Thalamic activation during slightly subphysiological glycemia in humans. Diabetes Care. 2012;35(12):2570-4. doi:10.2337/dc12-0297  PMCID:PMC3507561  PMID:22891254 
  49. Feasibility of prolonged continuous glucose monitoring in toddlers with type 1 diabetes. Pediatr Diabetes. 2012;13(4):301-7. doi:10.1111/j.1399-5448.2011.00837.x  PMID:22151826 
  50. Vitamin D deficiency and comorbidities in children with sickle cell anemia. Pediatr Hematol Oncol. 2012;29(3):261-6. doi:10.3109/08880018.2012.661034  PMID:22475302 
  51. Achievement of target A1C levels with negligible hypoglycemia and low glucose variability in youth with short-term type 1 diabetes and residual β-cell function. Diabetes Care. 2012;35(4):817-20. doi:10.2337/dc11-2190  PMCID:PMC3308298  PMID:22323414 
  52. A randomized clinical trial to assess the efficacy and safety of real-time continuous glucose monitoring in the management of type 1 diabetes in young children aged 4 to <10 years. Diabetes Care. 2012;35(2):204-10. doi:10.2337/dc11-1746  PMCID:PMC3263860  PMID:22210571 
  53. Glucose counterregulatory responses to hypoglycemia. Pediatr Endocrinol Rev. 2011;9(1):463-73; quiz 474-5. PMID:22783644 
  54. Partial inhibition of insulin secretion results in glucose intolerance but not hyperglucagonemia. Diabetes. 2011;60(4):1324-8. doi:10.2337/db10-1586  PMCID:PMC3064106  PMID:21378174 
  55. Imaging hypoglycemia's effects on the human brain Diabetic Hypoglycemia . 2010;3(2):3-9. 
  56. Hypoglycemia in Diabetes: Prevalence, Mechanisms, Impact and Prevention International Diabetes Monitor . 2009;6(21):206-209. 
  57. Terbutaline and the prevention of nocturnal hypoglycemia in type 1 diabetes. Diabetes Care. 2008;31(12):2271-2. doi:10.2337/dc08-0520  PMCID:PMC2584177  PMID:18782903 
  58. Attenuation of counterregulatory responses to recurrent hypoglycemia by active thalamic inhibition: a mechanism for hypoglycemia-associated autonomic failure. Diabetes. 2008;57(2):470-5. doi:10.2337/db07-1329  PMCID:PMC2435187  PMID:18003752 
  59. Basal insulin, glucagon, and growth hormone replacement. Am J Physiol Endocrinol Metab. 2007;293(5):E1303-10. doi:10.1152/ajpendo.00325.2007  PMID:17711984 
  60. Glucagon, in concert with insulin, supports the postabsorptive plasma glucose concentration in humans. Diabetes. 2007;56(10):2442-8. doi:10.2337/db07-0751  PMID:17606872 
  61. Nocturnal hypoglycemia in type 1 diabetes: an assessment of preventive bedtime treatments. J Clin Endocrinol Metab. 2006;91(6):2087-92. doi:10.1210/jc.2005-2798  PMID:16492699 
  62. Acute retroviruses and oncogenesis. Crit Rev Oncog. 1999;10(1-2):17-81. PMID:10327210 
  63. Semenkovich K, Bischoff A, Doty T, Nelson S, Siller AF, Hershey T, Arbeláez AM. Clinical presentation and memory function in youth with type 1 diabetes. Pediatric diabetes. 2016; 17(7):492-499. PMID: 26377697 PMCID: PMC4803626 
Last updated: 09/23/2022
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