Tarin Bigley  bigley@wustl.edu

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Education

  • BA, Summa Cum Laude, University of Wisconsin2008
  • PhD, Medical College of Wisconsin2014
  • MD, Medical College of Wisconsin2016

Training

  • Resident, St. Louis Children's Hospital-Pediatric Physician Scientist Training Program2016 - 2018
  • Clinical Fellow, Washington University-Pediatric Physician Training Scientist Program2018

Honors and Awards

  • Congenital CMV Conference and International CMV/Betaherpesvirus Workshop Travel Award2012
  • International Herpesvirus Workshop Early Travel Award2012
  • American Society for Virology Student Travel Grant2013
  • Journal of Virology Spotlight Article2013
  • Kayoko Ishizuka Award for Presentation at International Conferences2013
  • Medical College of Wisconsin Annual Research Day Poster Award2013
  • Travel Award to attend the MD/PhD Student Conference2013
  • American Society for Virology Postdoctoral Fellow Travel Grant2015
  • Medical College of Wisconsin Outstanding Dissertation Award2015
  • Armand J. Quick Award for Outstanding Senior Medical Students in Biochemistry2016
  • Chief Residents Award2016
  • James P. Keating Outstanding Resident Award2018
  • AAI Trainee Abstract Award2020 - 2021
  • David Gilstrap Memorial Award for Research in Immunology2021

Recent Publications view all (16)


  1. Murine Roseolovirus Disrupts Thymic Central Tolerance and Induces Autoimmune Gastritis Journal of Experimental Medicine. 2022;(10):1084. doi:jem.20211403  
  2. Murine Roseolovirus does not Accelerate Amyloid-B Pathology and Human Roseoloviruses are not Over-Represented in Alzheimer Disease Brains. Molecular Neurodegeneration. 2022;15(17):10. 
  3. Hobit Confers Tissue Dependent Programs to Type 1 Innate Lymphoid Cells PNAS. 2021;14(118):50. doi:e2117965118  
  4. X-linked Chronic Granulomatous Disease Presenting with Mediastinal Lipoblastoma and Adjacent Pneumonia Journal of Clinical Immunology. 2021;41(8):1969-1971. 
  5. NK Cells Metabolically Adapt to Infection to Promote Survival and Viral Clearance eLife. 2021;16:10. doi:e68484  
  6. The Double-Edged Sword of Immune Dysregulation. Current Opinion in Immunology. 2021;12(72):230-238. 
  7. Comparative Analysis of Roseoloviruses in Humans, Pigs, Mice, and Other Species. Viruses. 2019;11(12):1108. 
  8. SmgGDS is a Transient Nucleolar Protein that Protects Cells from Nucleolar Stress and Promotes the Cell Cycle by Regulating DREAM Complex Gene Expression. Oncogene. 2017;14(36):6873-6883. 
  9. Impact of a Cytomegalovirus Kinase Inhibitor on Infection and Neuronal Progenitor Cell Differentiation. Antiviral Research. 2016;129:67-73. 
  10. An Antagonistic Relationship between Human Cytomegalovirus pUL27 and pUL97 Activities during Infection. J Virol. 2015;(20):10230-46. 
  11. The MprB Extracytoplasmic Domain Negatively Regulates Activation of the Mycobacterium Tuberculosis MprAB Two-Component System. J Bacteriol. 2014;(2):391-406. 
  12. A Conserved Gammaherpesvirus Protein Kinase Targets Histone Deacetylases 1 and 2 to Facilitate Viral Replication in Primary Macrophages. J Virol. 2013;87(13):7314-25. 
  13. Human Cytomegalovirus pUL97 Regulates the Viral Major Immediate Early Promoter by Phosphorylation-Mediated Disruption of Histone Deacetylase 1 Binding. J Virol. 2013;87(13):7393-8408. 
  14. Human Cytomegalovirus pUL29/28 and pUL38 Repression of p53-Regulated p21CIP1 and Caspase 1 Promoters during Infection. J Virol. 2013;87(5):2463-74. 
  15. A Method for Quantifying Mechanical Properties of Tissue Following Viral Infection. PLoS One. 2012;7(8). doi:e42197  
  16. Conserved Gammaherpesvirus Kinase and Histone Variant H2AX Facilitate Gammaherpesvirus Latency in vivo. Virology. 2010;15;405(1):50-61. 
Last updated: 03/14/2022
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