Tunda Hidvegi, Ph.D.  tunde@wustl.edu

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Associate Professor of Pediatrics, Gastroenterology, Hepatology and Nutrition
Gastroenterology, Hepatology and Nutrition

phone: (314) 454-6173


  • PhD, Eotvos Lorand University1988
  • MS, Eotvos Lorand University1985

Recent Publications view all (34)

Publication Co-Authors

  1. Regulation of PGC1α downstream of the insulin signaling pathway plays a role in the hepatic proteotoxicity of mutant α1-antitrypsin deficiency variant Z Gastroenterology. 2022. doi: Gastroenterology . 2022 Mar 14;S0016-5085(22)00261-X. doi: 10.1053/j.gastro.2022.03.010. In Press Journal Pre-proof.  PMCID:35301011  PMID:35301011 
  2. An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z PLoS One. 2019;14(1):e0209748. doi:10.1371/journal.pone.0209748. eCollection 2019  PMID: 30673724 
  3. NFκB mitigates the pathological effects of misfolded α1-antitrypsin by activating autophagy and an integrated program of proteostasis mechanisms. Cell Death Differ. 2018. PMID:29795336 
  4. Enhancing Autophagy with Drugs or Lung-directed Gene Therapy Reverses the Pathological Effects of Respiratory Epithelial Cell Proteinopathy. J Biol Chem. 2015;290(50):29742-57. doi:10.1074/jbc.M115.691253  PMCID:PMC4705969  PMID:26494620 
  5. Fluphenazine reduces proteotoxicity in C. elegans and mammalian models of alpha-1-antitrypsin deficiency. PLoS One. 2014;9(1):e87260. doi:10.1371/journal.pone.0087260  PMCID:PMC3909079  PMID:24498058 
  6. Spontaneous hepatic repopulation in transgenic mice expressing mutant human α1-antitrypsin by wild-type donor hepatocytes. J Clin Invest. 2011;121(5):1930-4. doi:10.1172/JCI45260  PMCID:PMC3083768  PMID:21505264 
  7. The role of autophagy in alpha-1-antitrypsin deficiency. Methods Enzymol. 2011;499:33-54. doi:10.1016/B978-0-12-386471-0.00003-1  PMID:21683248 
  8. An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis. Science. 2010;329(5988):229-32. doi:10.1126/science.1190354  PMID:20522742 
  9. Regulator of G Signaling 16 is a marker for the distinct endoplasmic reticulum stress state associated with aggregated mutant alpha1-antitrypsin Z in the classical form of alpha1-antitrypsin deficiency. J Biol Chem. 2007;282(38):27769-80. doi:10.1074/jbc.M704330200  PMID:17635928 
  10. Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity. J Biol Chem. 2006;281(7):4467-76. doi:10.1074/jbc.M509409200  PMID:16365039 
  11. Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response. J Biol Chem. 2005;280(47):39002-15. doi:10.1074/jbc.M508652200  PMID:16183649 
  12. The proteasome participates in degradation of mutant alpha 1-antitrypsin Z in the endoplasmic reticulum of hepatoma-derived hepatocytes. J Biol Chem. 2001;276(48):44865-72. doi:10.1074/jbc.M103703200  PMID:11577074 
  13. Genetic disruption of the murine complement C3 promoter region generates deficient mice with extrahepatic expression of C3 mRNA. Immunopharmacology. 1999;42(1-3):135-49. PMID:10408374 
  14. Disruption of disulfide bonds is responsible for impaired secretion in human complement factor H deficiency. J Biol Chem. 1999;274(17):11782-8. PMID:10206995 
  15. Ragweed allergy: correlation between skin reactivity and in vitro complement activation. Immunol Lett. 1998;64(2-3):119-23. PMID:9870662 
  16. The severity of clinical symptoms in ragweed-allergic patients is related to the extent of ragweed-induced complement activation in their sera. Allergy. 1997;52(11):1110-4. PMID:9404564 
  17. Abrogation of the alternative complement pathway by targeted deletion of murine factor B. Proc Natl Acad Sci U S A. 1997;94(16):8720-5. PMCID:PMC23097  PMID:9238044 
  18. Two parallel routes of the complement-mediated antibody-dependent enhancement of HIV-1 infection. AIDS. 1997;11(8):949-58. PMID:9223728 
  19. Comparative study of the complement-activating and specific IgE-binding properties of ragweed pollen allergen. Clin Exp Immunol. 1997;108(1):122-7. PMCID:PMC1904628  PMID:9097920 
  20. In vitro complement activation by ragweed allergen extract in the sera of ragweed allergic and non-allergic persons. Immunol Lett. 1995;48(1):65-71. PMID:8847094 
  21. Interaction of complement and specific antibodies with the external glycoprotein 120 of HIV-1. Immunology. 1995;85(2):184-9. PMCID:PMC1383879  PMID:7642209 
  22. Role of humoral factors in the progression of HIV disease. Immunol Today. 1995;16(4):167-9. PMID:7734041 
  23. Competition of complement proteins and specific antibodies for binding to HIV-1 envelope antigens. Acta Microbiol Immunol Hung. 1994;41 Suppl:27-31. PMID:8075944 
  24. Quality of plasma separated from (buffy coat + plasma). An alternative way of blood processing. Acta Haematol Pol. 1994;25(1):47-53. PMID:8209614 
  25. Studies on the mechanism of complement-mediated inhibition of antibody binding to HIV gp41. Clin Exp Immunol. 1993;94(3):490-3. PMCID:PMC1534428  PMID:8252810 
  26. Complement activation decreases the ability of HIV transmembrane envelope protein to bind to specific antibody. AIDS. 1992;6(9):1050-1. PMID:1388901 
  27. The complement system in HIV disease. Immunol Invest. 1991;20(2):231-41. PMID:1864641 
  28. Concentration of C1 inhibitor in sera of healthy blood donors as studied by immunoenzymatic assay. Complement Inflamm. 1991;8(5-6):310-2. PMID:1802549 
  29. Differences in the complement activation induced by preformed and nascent immune complexes. Complement Inflamm. 1991;8(1):43-9. PMID:2049935 
  30. Hormonal regulation of complement biosynthesis in human cell lines--I. Androgens and gamma-interferon stimulate the biosynthesis and gene expression of C1 inhibitor in human cell lines U937 and HepG2. Mol Immunol. 1990;27(2):191-5. PMID:2157144 
  31. Hormonal regulation of complement biosynthesis in human cell lines--II. Upregulation of the biosynthesis of complement components C3, factor B and C1 inhibitor by interleukin-6 and interleukin-1 in human hepatoma cell line. Mol Immunol. 1990;27(2):197-201. PMID:2157145 
  32. FN-C1q and C1 INH C1r-C1s complexes as indicators of complement activation in patients with chronic lymphocytic leukaemia. Immunol Lett. 1989;22(1):1-6. PMID:2550362 
  33. Non-covalently bound C3 enhances lysis of rabbit erythrocytes through the alternative pathway. Immunology. 1985;56(4):735-41. PMCID:PMC1453793  PMID:3935572 
  34. Inhibition of the complement activation by an adrenal androgen, dehydroepiandrosterone. Complement. 1984;1(4):201-6. PMID:6242390 
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