Monica Hulbert, M.D.

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Associate Professor, Hematology and Oncology
Hematology and Oncology

phone: (314) 454-6018

Clinical Interests

As the director of the Sickle Cell Disease Program at St. Louis Children's Hospital, my goal is to ensure that children with sickle cell disease (SCD) receive optimal medical care, including both management of symptoms of SCD as well as treatments that lessen the severity of the disease. The Sickle Cell Disease Team includes physicians, nurses, nurse practitioners, social work, psychology, and other professionals who contribute to the inpatient and outpatient care of children and young adults with SCD.


  • BS, Indiana University1996
  • MD, Washington University School of Medicine2000


  • Residency in Pediatrics, St. Louis Children's Hospital2000 - 2003
  • Fellowship in Pediatric Hematology/Oncology, Washington University School of Medicine2003 - 2006

Licensure and Board Certification

  • 2006 - 2013IN, Medical Licensing Board
  • 2006 - 2016American Board of Pediatrics
  • 2009 - 2023American Board of Pediatrics, Subboard of Pediatric Hematology-Oncology
  • 2011 - PresMO, Board of Registration for the Healing Arts
  • 2019 - PresIL, Department of Financial and Professional Regulation

Honors and Awards

  • Best Doctors in St. Louis2015 - Pres
  • Robert Strunk, MD Award in Clinical Excellence, St. Louis Children's Hospital2021

Recent Publications view all (31)

Publication Co-Authors

  1. Silent Infarcts, White Matter Integrity, and Oxygen Metabolic Stress in Young Adults With and Without Sickle Cell Trait. Stroke. 2022;53(9):2887-2895. PMCID:PMC9398918  PMID:35545940 
  2. Normalization of cerebral hemodynamics following hematopoietic stem cell transplant in children with sickle cell disease. Blood. 2022. PMID:36040484 
  3. Cerebral oxygen metabolic stress is increased in children with sickle cell anemia compared to anemic controls. Am J Hematol. 2022;97(6):682-690. PMCID:PMC9081128  PMID:35113471 
  4. A Case Series of Kawasaki Disease in Children With Sickle Cell Disease. J Pediatr Hematol Oncol. 2021. PMID:34486560 
  5. Epstein-Barr virus-induced sickle hepatopathy. Pediatr Blood Cancer. 2021;68(9):e29196. PMID:34180131 
  6. Abatacept is effective as GVHD prophylaxis in unrelated donor stem cell transplantation for children with severe sickle cell disease Blood Advances. 2020;4(16):3894-3899. doi:10.1182/bloodadvances.2020002236  PMCID:PMC7448594  PMID:32813873 
  7. Higher executive abilities following a blood transfusion in children and young adults with sickle cell disease. Pediatr Blood Cancer. 2019;66(10):e27899. doi:10.1002/pbc.27899  PMCID:PMC6707832  PMID:31267645 
  8. Hydroxyurea reduces cerebral metabolic stress in patients with sickle cell anemia. Blood. 2019;133(22):2436-2444. PMCID:PMC6543515  PMID:30858231 
  9. Prevalence and nature of hearing loss in a cohort of children with sickle cell disease. Pediatr Blood Cancer. 2019;66(1):e27457. PMID:30207054 
  10. Regional oxygen extraction predicts border zone vulnerability to stroke in sickle cell disease. Neurology. 2018;90(13):e1134-e1142. PMCID:PMC5880632  PMID:29500287 
  11. Red cell exchange transfusions lower cerebral blood flow and oxygen extraction fraction in pediatric sickle cell anemia. Blood. 2017;131(9):1012-1021. PMID:29255068 
  12. Determining the longitudinal validity and meaningful differences in HRQL of the PedsQL™ Sickle Cell Disease Module. Health Qual Life Outcomes. 2017;15(1):124. PMCID:PMC5468970  PMID:28606098 
  13. Unrelated Umbilical Cord Blood Transplantation for Sickle Cell Disease Following Reduced Intensity Conditioning: Results of a Phase I Trial. Biol Blood Marrow Transplant. 2017;23(9):1587-1592. PMID:28578010 
  14. Increased complications of chronic erythrocytapheresis compared with manual exchange transfusions in children and adolescents with sickle cell disease. Pediatr Blood Cancer. 2017;64:e26635. PMID:28544309 
  15. Red blood cell transfusions during sickle cell anemia vaso-occlusive crises: a report from the magnesium in crisis (MAGiC) study. Transfusion. 2017;57(8):1891-1897. PMID:28500682 
  16. Large-Vessel Vasculopathy in Children With Sickle Cell Disease: A Magnetic Resonance Imaging Study of Infarct Topography and Focal Atrophy. Pediatr Neurol. 2017;69:49-57. PMCID:PMC5365370  PMID:28159432 
  17. Reduction in Overt and Silent Stroke Recurrence Rate Following Cerebral Revascularization Surgery in Children with Sickle Cell Disease and Severe Cerebral Vasculopathy. Pediatr Blood Cancer. 2016;63(8):1431-7. PMID:27106860 
  18. A multicenter randomized controlled trial of intravenous magnesium for sickle cell pain crisis in children. Blood. 2015;126(14):1651-1657. doi:10.1182/blood-2015-05-647107  PMID:26232172 
  19. Red blood cell storage duration is not associated with clinical outcomes for acute chest syndrome in children with sickle cell disease. Transfusion. 2015;55(11):2714-2721. doi:10.1111/trf.13176  PMID:26033266 
  20. Aggressive congenital juvenile myelomonocytic leukemia associated with somatic KRAS p.G13D mutation and concurrent germline IGF1R duplication. Leuk Lymphoma. 2015;56(4):1175-8. doi:10.3109/10428194.2014.953152  PMID:25110823 
  21. Health-related quality of life in children with sickle cell anemia: impact of blood transfusion therapy. Am J Hematol. 2015;90(2):139-43. doi:10.1002/ajh.23877  PMCID:PMC4304929  PMID:25345798 
  22. Higher-than-expected prevalence of silent cerebral infarcts in children with hemoglobin SC disease. Blood. 2015;125(2):416-7. doi:10.1182/blood-2014-10-605964  PMID:25573975 
  23. Cerebral vasculopathy in children with sickle cell anemia. Blood Cells Mol Dis. 2015;54(1):17-25. doi:10.1016/j.bcmd.2014.08.007  PMID:25294561 
  24. Clinical course of postthrombotic syndrome in children with history of venous thromboembolism. Blood Coagul Fibrinolysis. 2012;23(1):39-44. doi:10.1097/MBC.0b013e32834bdb1c  PMID:22089938 
  25. Fluorosis because of prolonged voriconazole therapy in a teenager with acute myelogenous leukemia. J Clin Oncol. 2011;29(32):e779-82. doi:10.1200/JCO.2011.35.9604  PMID:21969513 
  26. Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease. Blood. 2011;117(3):772-9. doi:10.1182/blood-2010-01-261123  PMCID:PMC3035071  PMID:20940417 
  27. Severe hypertriglyceridemia in an infant with red cell pyruvate kinase deficiency. Indian Pediatr. 2007;44(4):303-5. PMID:17468529 
  28. Primary hemorrhagic stroke in children with sickle cell disease is associated with recent transfusion and use of corticosteroids. Pediatrics. 2006;118(5):1916-24. doi:10.1542/peds.2006-1241  PMID:17079562 
  29. Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: a retrospective cohort study of 137 children with sickle cell anemia. J Pediatr. 2006;149(5):710-2. doi:10.1016/j.jpeds.2006.06.037  PMID:17095350 
  30. Pathology quiz case 1. Cervical neuroblastoma (NB). Arch Otolaryngol Head Neck Surg. 2005;131(2):172, 174. doi:10.1001/archotol.131.2.172  PMID:15723954 
  31. Neutropenic enterocolitis as a presenting complication of acute lymphoblastic leukemia: an unusual case marked by delayed perforation of the descending colon. J Pediatr Surg. 2004;39(7):e18-20. PMID:15213940 
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