Andrew B. Janowski MD MSCI  abjanowski@wustl.edu

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Assistant Professor, Infectious Diseases
Researcher, Pediatric Research
Infectious Diseases

phone: (314) 454-6050

Clinical Interests

Dr. Janowski evaluates and treats children with infections at St. Louis Children's Hospital. His research concentrates on the discovery of novel viruses and determining what diseases these novel viruses can cause in humans. His current focus is on a family of RNA viruses known as astroviruses. For the past 40 years, these viruses have been considered primary pathogens of the gastrointestinal tract. Recently, these viruses have been identified to cause central nervous system infections in humans and other mammals. He has developed the first cell culture and animal model of infection with astrovirus VA1, a recently discovered astrovirus strain that is the most commonly identified astrovirus from cases of human encephalitis in children and adults. Surprisingly, astrovirus VA1 also has the capacity to infect cells of the heart and to cause myocarditis in mice, suggesting this virus could also cause cardiovascular diseases in humans. He aims to understand the mechanisms in which this virus causes disease in the central nervous and cardiovascular systems, and to develop treatments for patients with astrovirus infections.

In addition, Dr Janowski is studying the stem-loop II motif, a highly conserved RNA sequence present in viruses of multiple families, including SARS-CoV-1, SARS-CoV-2, and astrovirus VA1. This element is essential for replication of astrovirus VA1, but interestingly, it is dispensable for SARS-CoV-2. The lab is currently studying why this motif can have differing levels of importance for the viral lifecycle, despite being highly conserved across these viruses.

Lab Website

Education

  • BS, Honors with distinctive scholastic achievement, University of Wisconsin-Madison2006
  • MD, Honors in Research, University of Wisconsin-Madison School of Medicine and Public Health2010
  • MSCI, Washington University School of Medicine2021

Training

  • Intern, Children's Hospital of Pittsburgh 2010 - 2011
  • Resident, Children's Hospital of Pittsburgh 2011 - 2013
  • Fellow , Pediatric Infectious Diseases, Washington University School of Medicine2013 - 2017

Licensure and Board Certification

  • 2013 - PresAmerican Board of Pediatrics
  • 2017 - PresAmerican Board of Pediatrics, Pediatric Infectious Diseases

Honors and Awards

  • William F. Vilas Scholarship2002
  • Wisconsin Academic Excellence Scholarship2002
  • Phi Kappa Phi2005
  • Phi Beta Kappa2006
  • Shapiro Summer Research Scholar2007
  • Harry A. Waisman Pediatrics Award Scholarship2010
  • Honors in Medical Student Research2010
  • Outstanding Fellow Teaching Award, Department of Pediatrics, Washington University School of Medicine2015
  • Pediatric Infectious Disease Society Fellow’s Video Contest Winner2015
  • 2nd place Outstanding Poster Presentation Pediatric Infectious Disease Society/St Jude Conference2017
  • NIH Loan repayment recipient2017 - 2019
  • CRTC Outstanding Citizenship Award2021

Recent Publications view all (17)


Publication Co-Authors

  1. Perceptions of risk of SARS-CoV-2 transmission in social and educational activities by infectious diseases and general pediatric healthcare providers, a pre-vaccine risk perception cross-sectional survey. PLoS One. 2022;17(2):e0263767. PMID:35148344 
  2. High Seropositivity Rate of Neutralizing Antibodies to Astrovirus VA1 in Human Populations. mSphere. 2021;e0048421. PMID:34468168 
  3. Progression of SARS-CoV-2 Seroprevalence in St. Louis, Missouri, through January 2021. mSphere. 2021;e0045021. PMID:34346705 
  4. Beyond the Gastrointestinal Tract: The Emerging and Diverse Tissue Tropisms of Astroviruses. Viruses. 2021;13(5). PMID:33922259 
  5. Seroprevalence of SARS-CoV-2 Antibodies in Children and Adults in St. Louis, Missouri, USA. mSphere. 2021;6(1). PMID:33536325 
  6. Variability in the Use of Novel Diagnostic Technology in Children With Suspected Encephalitis and in the Management of Emerging Encephalitides by Pediatric Infectious Disease Providers. J Pediatric Infect Dis Soc. 2020. PMID:33347568 
  7. Antiviral activity of ribavirin and favipiravir against human astroviruses. J Clin Virol. 2020;123:104247. PMID:31864069 
  8. Astrovirus replication in human intestinal enteroids reveals multi-cellular tropism and an intricate host innate immune landscape. PLoS Pathog. 2019;15(10):e1008057. PMID:31671153 
  9. Differential In Vitro Infection of Neural Cells by Astroviruses. MBio. 2019;10(4). PMID:31289185 
  10. Therapeutic efficacy of favipiravir against Bourbon virus in mice. PLoS Pathog. 2019;15(6):e1007790. PMCID:PMC6564012  PMID:31194854 
  11. Infection and Propagation of Astrovirus VA1 in Cell Culture. Curr Protoc Microbiol. 2018;e73. PMID:30444308 
  12. Whole transcriptome profiling reveals major cell types in the cellular immune response against acute and chronic active Epstein-Barr virus infection. Sci Rep. 2017;7(1):17775. PMCID:PMC5736708  PMID:29259291 
  13. Propagation of astrovirus VA1, a neurotropic human astrovirus, in cell culture. J Virol. 2017. PMCID:PMC5599743  PMID:28701405 
  14. Statoviruses, A novel taxon of RNA viruses present in the gastrointestinal tracts of diverse mammals. Virology. 2017;504:36-44. PMCID:PMC5515247  PMID:28152382 
  15. Of the Phrensy: an update on the epidemiology and pathogenesis of bacterial meningitis in the pediatric population. F1000Res. 2017;6. PMCID:PMC5288681  PMID:28184287 
  16. Piperacillin-Tazobactam Usage at a Tertiary Pediatric Hospital: An Antimicrobial Stewardship Review. J Pediatric Infect Dis Soc. 2016;5(3):342-5. PMID:26407269 
  17. Hyperexpansion of RNA Bacteriophage Diversity. PLoS Biol. 2016;14(3):e1002409. PMCID:PMC4807089  PMID:27010970 
Last updated: 09/11/2022
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