Cliff J. Luke, Ph.D.

Profile picture
Associate Professor of Pediatrics, Newborn Medicine
Newborn Medicine

phone: (314) 454-6148


  • BSc, Hons II(i), University of Liverpool1994
  • PhD, University of Surrey1998


  • Postodoctoral Fellow, The Children's Hospital1998 - 2001
  • Research fellow in Pediatrics, Harvard Medical School1998 - 2001
  • Research Associate, The Children's Hospital2001 - 2004

Honors and Awards

  • Aaron Janoff Recipient of the Young Investigator Award2001

Recent Publications view all (41)

Publication Co-Authors

  1. Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins. Commun Biol. 2022;5(1):47. PMCID:PMC8755814  PMID:35022507 
  2. SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation. Commun Biol. 2022;5(1):46. PMCID:PMC8755728  PMID:35022555 
  3. Interleukin-22 signaling attenuates necrotizing enterocolitis by promoting epithelial cell regeneration. Cell Rep Med. 2021;2(6):100320. PMCID:PMC8233697  PMID:34195684 
  4. Functional characterization of four ATP-binding cassette transporter A3 gene (ABCA3) variants. Hum Mutat. 2020;41(7):1298-1307. PMCID:PMC7292786  PMID:32196812 
  5. NADPH oxidase controls pulmonary neutrophil infiltration in the response to fungal cell walls by limiting LTB4. Blood. 2020;135(12):891-903. PMCID:PMC7082617  PMID:31951647 
  6. Patient-derived small intestinal myofibroblasts direct perfused, physiologically responsive capillary development in a microfluidic Gut-on-a-Chip Model. Sci Rep. 2020;10(1):3842. PMCID:PMC7051952  PMID:32123209 
  7. Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock. PNAS. 2019;116(33):16497-16506. doi:0.1073/pnas.1822157116  PMID:31346084 
  8. CemOrange2 fusions facilitate multifluorophore subcellular imaging in C. elegans. PLoS One. 2019;14(3):e0214257. doi:10.1371/journal.pone.0214257  PMCID:PMC6435234  PMID:30913273 
  9. Breast Milk Enhances Growth of Enteroids: An Ex Vivo Model of Cell Proliferation. J Vis Exp. 2018;(132). PMCID:PMC5912412  PMID:29553558 
  10. Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer. Br J Cancer. 2017. doi:10.1038/bjc.2017.390  PMID:29112685 
  11. Enteroviruses infect human enteroids and induce antiviral signaling in a cell lineage-specific manner. Proc Natl Acad Sci U S A. 2017;114(7):1672-1677. PMCID:PMC5320971  PMID:28137842 
  12. Activation of the Caenorhabditis elegans Degenerin Channel by Shear Stress Requires the MEC-10 Subunit. J Biol Chem. 2016;291(27):14012-22. PMCID:PMC4933161  PMID:27189943 
  13. SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin. Biochemistry. 2015;54(45):6756-9. PMCID:PMC4900762  PMID:26497600 
  14. Human SERPINB12 Is an Abundant Intracellular Serpin Expressed in Most Surface and Glandular Epithelia. J Histochem Cytochem. 2015;63(11):854-65. PMCID:PMC4812677  PMID:26220980 
  15. Deficient and Null Variants of SERPINA1 Are Proteotoxic in a Caenorhabditis elegans Model of α1-Antitrypsin Deficiency. PLoS One. 2015;10(10):e0141542. PMCID:PMC4626213  PMID:26512890 
  16. Microscopic Investigation of Protein Function in C. elegans Using Fluorescent Imaging. Curr Protoc Cytom. 2015;74:12.41.1-12.41.17. PMID:26423692 
  17. The aggregation-prone intracellular serpin SRP-2 fails to transit the ER in Caenorhabditis elegans. Genetics. 2015;200(1):207-19. PMCID:PMC4423363  PMID:25786854 
  18. A genome-wide RNAi screen identifies potential drug targets in a C. elegans model of α1-antitrypsin deficiency. Hum Mol Genet. 2014;23(19):5123-32. PMCID:PMC4159156  PMID:24838285 
  19. A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover. Hum Mol Genet. 2014;23(19):5109-22. PMCID:PMC4159155  PMID:24838286 
  20. Isolation of serpin-interacting proteins in C. elegans using protein affinity purification. Methods. 2014;68(3):536-41. PMCID:PMC4113314  PMID:24798811 
  21. Non-microfluidic methods for imaging live C. elegans. Methods. 2014;68(3):542-7. PMCID:PMC4812562  PMID:24836996 
  22. C. elegans in high-throughput drug discovery. Adv Drug Deliv Rev. 2014;69-70:247-53. PMCID:PMC4019719  PMID:24333896 
  23. A small conductance calcium-activated K+ channel in C. elegans, KCNL-2, plays a role in the regulation of the rate of egg-laying. PLoS One. 2013;8(9):e75869. PMCID:PMC3769271  PMID:24040423 
  24. A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans. PLoS One. 2012;7(7):e40145. PMCID:PMC3388072  PMID:22768338 
  25. Using C. elegans to identify the protease targets of serpins in vivo. Methods Enzymol. 2011;499:283-99. PMCID:PMC4374438  PMID:21683259 
  26. Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z. PLoS One. 2010;5(11):e15460. PMCID:PMC2980495  PMID:21103396 
  27. Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol. 2008;294(5):L932-41. PMCID:PMC2387194  PMID:18310226 
  28. An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury. Cell. 2007;130(6):1108-19. PMCID:PMC2128786  PMID:17889653 
  29. SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change. J Biol Chem. 2007;282(34):24948-60. PMID:17562709 
  30. The Caenorhabditis elegans muscle specific serpin, SRP-3, neutralizes chymotrypsin-like serine peptidases. Biochemistry. 2006;45(14):4474-80. PMCID:PMC2654365  PMID:16584183 
  31. Selective conservation of the RSL-encoding, proteinase inhibitory-type, clade L serpins in Caenorhabditis species. Front Biosci. 2006;11:581-94. PMID:16146754 
  32. Identification and activity of a lower eukaryotic serine proteinase inhibitor (serpin) from Cyanea capillata: analysis of a jellyfish serpin, jellypin. Biochemistry. 2004;43(37):11750-9. PMID:15362859 
  33. The amplified mouse squamous cell carcinoma antigen gene locus contains a serpin (Serpinb3b) that inhibits both papain-like cysteine and trypsin-like serine proteinases. Genomics. 2004;84(1):166-75. PMID:15203214 
  34. SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins. J Biol Chem. 2004;279(15):15448-59. PMID:14739286 
  35. Serpin production using rapid in vitro transcription/translation systems. Methods. 2004;32(2):191-8. PMID:14698632 
  36. The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases. Biochemistry. 2002;41(9):3189-99. PMID:11863458 
  37. SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases. J Biol Chem. 2001;276(52):49320-30. PMID:11604408 
  38. Recombinant Semliki Forest virus vector exhibits potential for avian virus vaccine development. Vaccine. 2001;19(23-24):3116-23. PMID:11312006 
  39. Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. Int J Cancer. 2000;89(4):368-77. PMID:10956412 
  40. Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage. Biochemistry. 2000;39(24):7081-91. PMID:10852705 
  41. Development of specific monoclonal antibodies and a sensitive discriminatory immunoassay for the circulating tumor markers SCCA1 and SCCA2. Clin Chim Acta. 2000;295(1-2):107-27. PMID:10767398 
Last updated: 08/09/2022
© 2022 by Washington University in St. Louis
One Brookings Drive, St. Louis, MO 63130