Department of Pediatrics

Education

• BSc, University of Mumbai, 2002
• MSc, University of Mumbai, 2004
• PhD, National Brain Research Centre, 2011

Training

• Postdoctoral Associate, Baylor College of Medicine, 2011 - 2017

Honors and Awards

• Sir Currimbhoy Ebrahim and Bai Khanoobai Noor Mahomed Jairazbhoy Peerbhoy Scholarship for academic excellence, University of Mumbai, India, 2002 - 2003
• Research fellowship, Lady Tata Memorial Trust, Mumbai, India, 2003 - 2004
• Senior Research Fellowship, Council of Scientific and Industrial Research (CSIR), India, 2008 - 2010
• Dean’s Award of Excellence, Baylor College of Medicine, Houston, 2015 - 2016

Recent Publications view all (16)

Publication Co-Authors

Jaiprakash Sharma

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Shalaka Mulherkar

1. Duman JG, Blanco FA, Cronkite CA, Ru Q, Erikson KC, Mulherkar S, Saifullah AB, Firozi K, Tolias KF. Rac-maninoff and Rho-vel: The symphony of Rho-GTPase signaling at excitatory synapses. Small GTPases. 2021;1-34. PMID:33955328 
2. Jinxuan X Cheng, Federico Scala, Francisco A Blanco, Sanyong Niu, Karen Firozi, Laura Keehan, Shalaka Mulherkar, Manolis Froudarakis, Lingyong Li, Joseph G Duman, Xiaolong Jiang, Kimberley F Tolias. The Rac-GEF Tiam1 Promotes Dendrite and Synapse Stabilization of Dentate Granule Cells and Restricts Hippocampal-Dependent Memory Functions J Neurosci . 2020;JN-RM-3271-17.. doi:10.1523/JNEUROSCI.3271-17.2020  PMID:33328293 
3. Scala F, Kobak D, Bernabucci M, Bernaerts Y, Cadwell CR, Castro JR, Hartmanis L, Jiang X, Laturnus S, Miranda E, Mulherkar S, Tan ZH, Yao Z, Zeng H, Sandberg R, Berens P, Tolias AS. Phenotypic variation of transcriptomic cell types in mouse motor cortex. Nature. 2020. PMID:33184512 
4. Cadwell CR, Scala F, Fahey PG, Kobak D, Mulherkar S, Sinz FH, Papadopoulos S, Tan ZH, Johnsson P, Hartmanis L, Li S, Cotton RJ, Tolias KF, Sandberg R, Berens P, Jiang X, Tolias AS. Cell type composition and circuit organization of clonally related excitatory neurons in the juvenile mouse neocortex. Elife. 2020;9. PMCID:PMC7162653  PMID:32134385 
5. Mulherkar S, Tolias KF. RhoA-ROCK Signaling as a Therapeutic Target in Traumatic Brain Injury. Cells. 2020;9(1). PMCID:PMC7016605  PMID:31963704 
6. Duman JG, Mulherkar S, Tu YK, Erikson KC, Tzeng CP, Mavratsas VC, Ho TS, Tolias KF. The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest. Elife. 2019;8. PMCID:PMC6713510  PMID:31461398 
7. Duman JG, Dinh J, Zhou W, Cham H, Mavratsas VC, Paveškovic M, Mulherkar S, McGovern SL, Tolias KF, Grosshans DR. Memantine prevents acute radiation-induced toxicities at hippocampal excitatory synapses. Neuro Oncol. 2018;20(5):655-665. PMCID:PMC5892158  PMID:29112734 
8. Mulherkar S, Firozi K, Huang W, Uddin MD, Grill RJ, Costa-Mattioli M, Robertson C, Tolias KF. RhoA-ROCK Inhibition Reverses Synaptic Remodeling and Motor and Cognitive Deficits Caused by Traumatic Brain Injury. Sci Rep. 2017;7(1):10689. PMCID:PMC5587534  PMID:28878396 
9. Duman JG, Mulherkar S, Tu YK, X Cheng J, Tolias KF. Mechanisms for spatiotemporal regulation of Rho-GTPase signaling at synapses. Neurosci Lett. 2015;601:4-10. PMCID:PMC4513188  PMID:26003445 
10. Mulherkar S, Uddin MD, Couvillon AD, Sillitoe RV, Tolias KF. The small GTPases RhoA and Rac1 regulate cerebellar development by controlling cell morphogenesis, migration and foliation. Dev Biol. 2014;394(1):39-53. PMCID:PMC4163514  PMID:25128586 
11. Um K, Niu S, Duman JG, Cheng JX, Tu YK, Schwechter B, Liu F, Hiles L, Narayanan AS, Ash RT, Mulherkar S, Alpadi K, Smirnakis SM, Tolias KF. Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex. Dev Cell. 2014;29(6):701-15. PMCID:PMC4111230  PMID:24960694 
12. Mulherkar S, Liu F, Chen Q, Narayanan A, Couvillon AD, Shine HD, Tolias KF. The small GTPase RhoA is required for proper locomotor circuit assembly. PLoS One. 2013;8(6):e67015. PMCID:PMC3692541  PMID:23825607 
13. Sharma J, Mulherkar S, Mukherjee D, Jana NR. Malin regulates Wnt signaling pathway through degradation of dishevelled2. J Biol Chem. 2012;287(9):6830-9. PMCID:PMC3307269  PMID:22223637 
14. Mulherkar SA, Jana NR. Loss of dopaminergic neurons and resulting behavioural deficits in mouse model of Angelman syndrome. Neurobiol Dis. 2010;40(3):586-92. PMID:20696245 
15. Mulherkar SA, Sharma J, Jana NR. The ubiquitin ligase E6-AP promotes degradation of alpha-synuclein. J Neurochem. 2009;110(6):1955-64. PMID:19645749 
16. Goswami A, Dikshit P, Mishra A, Mulherkar S, Nukina N, Jana NR. Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction. Biochem Biophys Res Commun. 2006;342(1):184-90. PMID:16472774