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Shalaka Mulherkar
mshalaka@wustl.edu
Assistant Professor of Pediatrics, Genetics and Genomic Medicine
Genetics and Genomic Medicine
phone: (314) 454-6093
Education
BSc,
University of Mumbai
,
2002
MSc,
University of Mumbai
,
2004
PhD,
National Brain Research Centre
,
2011
Training
Postdoctoral Associate, Baylor College of Medicine
,
2011
-
2017
Honors and Awards
Sir Currimbhoy Ebrahim and Bai Khanoobai Noor Mahomed Jairazbhoy Peerbhoy Scholarship for academic excellence, University of Mumbai, India
,
2002
- 2003
Research fellowship, Lady Tata Memorial Trust, Mumbai, India
,
2003
- 2004
Senior Research Fellowship, Council of Scientific and Industrial Research (CSIR), India
,
2008
- 2010
Dean’s Award of Excellence, Baylor College of Medicine, Houston
,
2015
- 2016
Recent Publications
view all (16)
Publication Co-Authors
Jaiprakash Sharma
Duman JG, Blanco FA, Cronkite CA, Ru Q, Erikson KC, Mulherkar S, Saifullah AB, Firozi K, Tolias KF.
Rac-maninoff and Rho-vel: The symphony of Rho-GTPase signaling at excitatory synapses.
Small GTPases
.
2021;1-34.
PMID:
33955328
Jinxuan X Cheng, Federico Scala, Francisco A Blanco, Sanyong Niu, Karen Firozi, Laura Keehan, Shalaka Mulherkar, Manolis Froudarakis, Lingyong Li, Joseph G Duman, Xiaolong Jiang, Kimberley F Tolias.
The Rac-GEF Tiam1 Promotes Dendrite and Synapse Stabilization of Dentate Granule Cells and Restricts Hippocampal-Dependent Memory Functions
J Neurosci
.
2020;JN-RM-3271-17..
doi:
10.1523/JNEUROSCI.3271-17.2020
PMID:
33328293
Scala F, Kobak D, Bernabucci M, Bernaerts Y, Cadwell CR, Castro JR, Hartmanis L, Jiang X, Laturnus S, Miranda E, Mulherkar S, Tan ZH, Yao Z, Zeng H, Sandberg R, Berens P, Tolias AS.
Phenotypic variation of transcriptomic cell types in mouse motor cortex.
Nature
.
2020.
PMID:
33184512
Cadwell CR, Scala F, Fahey PG, Kobak D, Mulherkar S, Sinz FH, Papadopoulos S, Tan ZH, Johnsson P, Hartmanis L, Li S, Cotton RJ, Tolias KF, Sandberg R, Berens P, Jiang X, Tolias AS.
Cell type composition and circuit organization of clonally related excitatory neurons in the juvenile mouse neocortex.
Elife
.
2020;9.
PMCID:
PMC7162653
PMID:
32134385
Mulherkar S, Tolias KF.
RhoA-ROCK Signaling as a Therapeutic Target in Traumatic Brain Injury.
Cells
.
2020;9
(1).
PMCID:
PMC7016605
PMID:
31963704
Duman JG, Mulherkar S, Tu YK, Erikson KC, Tzeng CP, Mavratsas VC, Ho TS, Tolias KF.
The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest.
Elife
.
2019;8.
PMCID:
PMC6713510
PMID:
31461398
Duman JG, Dinh J, Zhou W, Cham H, Mavratsas VC, Paveškovic M, Mulherkar S, McGovern SL, Tolias KF, Grosshans DR.
Memantine prevents acute radiation-induced toxicities at hippocampal excitatory synapses.
Neuro Oncol
.
2018;20
(5):
655-665.
PMCID:
PMC5892158
PMID:
29112734
Mulherkar S, Firozi K, Huang W, Uddin MD, Grill RJ, Costa-Mattioli M, Robertson C, Tolias KF.
RhoA-ROCK Inhibition Reverses Synaptic Remodeling and Motor and Cognitive Deficits Caused by Traumatic Brain Injury.
Sci Rep
.
2017;7
(1):
10689.
PMCID:
PMC5587534
PMID:
28878396
Duman JG, Mulherkar S, Tu YK, X Cheng J, Tolias KF.
Mechanisms for spatiotemporal regulation of Rho-GTPase signaling at synapses.
Neurosci Lett
.
2015;601:4-10.
PMCID:
PMC4513188
PMID:
26003445
Mulherkar S, Uddin MD, Couvillon AD, Sillitoe RV, Tolias KF.
The small GTPases RhoA and Rac1 regulate cerebellar development by controlling cell morphogenesis, migration and foliation.
Dev Biol
.
2014;394
(1):
39-53.
PMCID:
PMC4163514
PMID:
25128586
Um K, Niu S, Duman JG, Cheng JX, Tu YK, Schwechter B, Liu F, Hiles L, Narayanan AS, Ash RT, Mulherkar S, Alpadi K, Smirnakis SM, Tolias KF.
Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex.
Dev Cell
.
2014;29
(6):
701-15.
PMCID:
PMC4111230
PMID:
24960694
Mulherkar S, Liu F, Chen Q, Narayanan A, Couvillon AD, Shine HD, Tolias KF.
The small GTPase RhoA is required for proper locomotor circuit assembly.
PLoS One
.
2013;8
(6):
e67015.
PMCID:
PMC3692541
PMID:
23825607
Sharma J, Mulherkar S, Mukherjee D, Jana NR.
Malin regulates Wnt signaling pathway through degradation of dishevelled2.
J Biol Chem
.
2012;287
(9):
6830-9.
PMCID:
PMC3307269
PMID:
22223637
Mulherkar SA, Jana NR.
Loss of dopaminergic neurons and resulting behavioural deficits in mouse model of Angelman syndrome.
Neurobiol Dis
.
2010;40
(3):
586-92.
PMID:
20696245
Mulherkar SA, Sharma J, Jana NR.
The ubiquitin ligase E6-AP promotes degradation of alpha-synuclein.
J Neurochem
.
2009;110
(6):
1955-64.
PMID:
19645749
Goswami A, Dikshit P, Mishra A, Mulherkar S, Nukina N, Jana NR.
Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction.
Biochem Biophys Res Commun
.
2006;342
(1):
184-90.
PMID:
16472774
Last updated: 09/29/2021
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