Department of Pediatrics

Education

• MBBS, Rajiv Gandhi University of Health Sciences, 2011
• MSc, KINGS-PGT Scholarship, King's College London, 2012
• PhD, KINGS-GSIRS international studentship, King's College London, 2017

Training

• Postdoctoral Research Fellow, LABioMed at Harbor-UCLA Medical Center, 2017 - 2018

Licensure and Board Certification

• 2011 - PresKarnataka Medical Council (KMC)

Honors and Awards

• KINGS-PGT Scholarship, 2011 - 2012
• KINGS-GSIRS international studentship, 2013 - 2017
• Best “Omics” Poster – 16th International Conference on Neuronal Ceroid Lipofuscinoses (NCL2018), 2018

Recent Publications view all (12)

Publication Co-Authors

Marco Sardiello

Jonathan D Cooper, Ph.D.

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Hemanth Ramesh Nelvagal

1. Nelvagal HR, Lange J, Takahashi K, Tarczyluk-Wells MA, Cooper JD. Pathomechanisms in the neuronal ceroid lipofuscinoses. Biochim Biophys Acta Mol Basis Dis. 2020;1866(9):165570. PMID:31678162 
2. Nelvagal HR, Cooper JD . An update on the progress of preclinical models for guiding therapeutic management of neuronal ceroid lipofuscinosis Expert Opinion on Orphan Drugs. 2019;7(12):555-568. doi:https://doi.org/10.1080/21678707.2019.1703672  
3. Nelvagal HR, Cooper JD . Translating preclinical models of neuronal ceroid lipofuscinosis: progress and prospects. Expert Opinion on Orphan Drugs. 2018;5(9):727-740. doi:https://doi.org/10.1080/21678707.2017.1360182  
4. Cooper JD, Nelvagal HR. Progress toward Fulfilling the Potential of Immunomodulation in Childhood Neurodegeneration? Mol Ther. 2017;25(8):1743-1745. PMCID:PMC5542794  PMID:28625570 
5. Shyng C, Nelvagal HR, Dearborn JT, Tyynelä J, Schmidt RE, Sands MS, Cooper JD. Synergistic effects of treating the spinal cord and brain in CLN1 disease. Proc Natl Acad Sci U S A. 2017;114(29):E5920-E5929. PMCID:PMC5530669  PMID:28673981 
6. Palmieri M, Pal R, Nelvagal HR, Lotfi P, Stinnett GR, Seymour ML, Chaudhury A, Bajaj L, Bondar VV, Bremner L, Saleem U, Tse DY, Sanagasetti D, Wu SM, Neilson JR, Pereira FA, Pautler RG, Rodney GG, Cooper JD, Sardiello M. Corrigendum: mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases. Nat Commun. 2017;8:15793. PMCID:PMC5474731  PMID:28607479 
7. Palmieri M, Pal R, Nelvagal HR, Lotfi P, Stinnett GR, Seymour ML, Chaudhury A, Bajaj L, Bondar VV, Bremner L, Saleem U, Tse DY, Sanagasetti D, Wu SM, Neilson JR, Pereira FA, Pautler RG, Rodney GG, Cooper JD, Sardiello M. mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases. Nat Commun. 2017;8:14338. PMCID:PMC5303831  PMID:28165011 
8. Cooper JD, Tarczyluk MA, Nelvagal HR. Towards a new understanding of NCL pathogenesis. Biochim Biophys Acta. 2015;1852(10 Pt B):2256-61. PMID:26026924 
9. Lu JY, Nelvagal HR, Wang L, Birnbaum SG, Cooper JD, Hofmann SL. Intrathecal enzyme replacement therapy improves motor function and survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis. Mol Genet Metab. 2015;116(1-2):98-105. PMID:25982063 
10. Cooper JD, Brooks HR, Nelvagal HR. Quantifying storage material accumulation in tissue sections. Methods Cell Biol. 2015;126:349-56. PMID:25665454 
11. Sondhi D, Scott EC, Chen A, Hackett NR, Wong AM, Kubiak A, Nelvagal HR, Pearse Y, Cotman SL, Cooper JD, Crystal RG. Partial correction of the CNS lysosomal storage defect in a mouse model of juvenile neuronal ceroid lipofuscinosis by neonatal CNS administration of an adeno-associated virus serotype rh.10 vector expressing the human CLN3 gene. Hum Gene Ther. 2014;25(3):223-39. PMCID:PMC3955974  PMID:24372003 
12. Groh J, Kühl TG, Ip CW, Nelvagal HR, Sri S, Duckett S, Mirza M, Langmann T, Cooper JD, Martini R. Immune cells perturb axons and impair neuronal survival in a mouse model of infantile neuronal ceroid lipofuscinosis. Brain. 2013;136(Pt 4):1083-101. PMID:23485853