Jaiprakash Sharma  j.sharma@wustl.edu

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Instructor in Pediatrics, Genetics and Genomic Medicine
Genetics and Genomic Medicine

phone: (314) 454-6093


  • PhD, National Brain Research Centre2012

Recent Publications view all (14)

Publication Co-Authors

  1. A CLN6-CLN8 complex recruits lysosomal enzymes at the ER for Golgi transfer. J Clin Invest. 2020;130(8):4118-4132. PMCID:PMC7410054  PMID:32597833 
  2. Lysosome biogenesis in health and disease. J Neurochem. 2019;148(5):573-589. PMCID:PMC6368902  PMID:30092616 
  3. CLN8 is an endoplasmic reticulum cargo receptor that regulates lysosome biogenesis. Nat Cell Biol. 2018;20(12):1370-1377. PMCID:PMC6277210  PMID:30397314 
  4. Lysosomes and Brain Health. Annu Rev Neurosci. 2018;41:255-276. PMID:29661037 
  5. NADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson's disease. Sci Rep. 2016;6:22866. PMCID:PMC4785399  PMID:26960433 
  6. Identification of a peptide inhibitor of the RPM-1 · FSN-1 ubiquitin ligase complex. J Biol Chem. 2014;289(50):34654-66. PMCID:PMC4263871  PMID:25326385 
  7. Neuronatin-mediated aberrant calcium signaling and endoplasmic reticulum stress underlie neuropathology in Lafora disease. J Biol Chem. 2013;288(13):9482-90. PMCID:PMC3611017  PMID:23408434 
  8. Malin regulates Wnt signaling pathway through degradation of dishevelled2. J Biol Chem. 2012;287(9):6830-9. PMCID:PMC3307269  PMID:22223637 
  9. Lafora disease ubiquitin ligase malin promotes proteasomal degradation of neuronatin and regulates glycogen synthesis. Neurobiol Dis. 2011;44(1):133-41. PMID:21742036 
  10. Sequestration of chaperones and proteasome into Lafora bodies and proteasomal dysfunction induced by Lafora disease-associated mutations of malin. Hum Mol Genet. 2010;19(23):4726-34. PMID:20858601 
  11. Capsaicin induces apoptosis through ubiquitin-proteasome system dysfunction. J Cell Biochem. 2010;109(5):933-42. PMID:20069556 
  12. Co-chaperone CHIP stabilizes aggregate-prone malin, a ubiquitin ligase mutated in Lafora disease. J Biol Chem. 2010;285(2):1404-13. PMCID:PMC2801266  PMID:19892702 
  13. The ubiquitin ligase E6-AP promotes degradation of alpha-synuclein. J Neurochem. 2009;110(6):1955-64. PMID:19645749 
  14. E6-AP promotes misfolded polyglutamine proteins for proteasomal degradation and suppresses polyglutamine protein aggregation and toxicity. J Biol Chem. 2008;283(12):7648-56. PMID:18201976 
Last updated: 09/29/2021
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