Stephen Stone, M.D.

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Assistant Professor, Endocrinology and Diabetes
Researcher, Pediatric Research
Endocrinology and Diabetes


Clinical Interests

I am extremely excited to join the faculty at Washington University! My practice philosophy hopes to balance the science of medicine with a holistic approach to patient care. As a result, I am committed to developing individualized diagnostic and treatment plans based on a patient and family’s specific needs. In particular, I pride myself on communication and therefore hope to clearly articulate the complex aspects of endocrinology and diabetes in a practical and digestible manner. Furthermore, I hope to offer the latest advances in modern endocrinology and diabetes technology available to my patients.

My clinical interests include utilizing insulin pumps and continuous glucose monitors in the management of children with diabetes. I am a co-leader of a multidisciplinary team for the use of technology in caring for children with diabetes. In addition to type 1 diabetes, I have a strong interest in managing disorders of the thyroid gland including Hashimoto’s and Graves’ disease. Finally, I enjoy helping care for children with rare or complex conditions resulting in diabetes, insulin resistance, or obesity. This includes monogenic diabetes, Wolfram syndrome, chronic recurrent pancreatitis, and insulin-mediated pseudoacromegaly.

My interest in caring for children with rare and complex diseases has spun into my career as a physician-scientist. My research aims to combine cutting edge genomic and metabolomic techniques with traditional endocrine physiologic testing. This precision medicine approach to endocrinology has led to the discovery of several novel gene variants, and has helped me describe a novel insulin resistance syndrome. I am hopeful that this approach will not only aid in the diagnosis of complex endocrine diseases, but will also lead to an improved understanding of the basic biology of insulin signaling and resistance. Therefore, these discoveries hold the potential to revolutionize the way we care for children with both common and rare diseases.

In my free time, I enjoy exploring St. Louis with my family. My hobbies include drawing, illustration, fishing, and bicycling.


  • BS, University of Illinois at Chicago2005
  • MD, Chicago Medical School at Rosalind Franklin University of Medicine & Science2010


  • Intern, Medical College of Wisconsin Affiliated Hospitals2010 - 2011
  • Resident, Medical College of Wisconsin Affiliated Hospitals2011 - 2013
  • Fellow, Washington University School of Medicine2013 - 2016

Licensure and Board Certification

  • 2012 - 2014WI, Medical License
  • 2013 - PresMO, Medical License
  • 2013General Pediatrics
  • 2017Pediatric Endocrinology

Honors and Awards

  • Honors in Pathology Program, Chicago Medical School2007
  • Elected to the Arnold P. Gold Humanism in Medicine Honor Society2010
  • Eddy Award for Outstanding 3rd Year Pediatric Resident2013
  • Golden Syringe Award for Excellence in Pediatric Endocrinology2015
  • 1st Place Poster, Clinical / Translational Science Category, Diabetes Research Day Symposium2016
  • Children's Direct Triple Crown Award2020
  • 2020 Journal of the Endocrine Society Manuscript on Insulin Mediated Pseudoacromegaly was highlighted in a Special Issue of the Endocrine Society Thematic issue on Rare Endocrine Disorders2021
  • 2020 Journal of the Endocrine Society Manuscript on Insulin Mediated Pseudoacromegaly was highlighted in a Special Issue of the Endocrine Society Thematic issue on Bone Research2022

Recent Publications view all (7)

Publication Co-Authors

  1. Identification of a novel hepatocyte nuclear factor-1 alpha (HNF1A) variant in maturity onset diabetes of the young type 3 (HNF1A-MODY). Endocrinol Diabetes Metab Case Rep. . 2022;21(0118). doi:10.1530/EDM-21-0118  PMCID:PMC9066565  PMID:35466084 
  2. A phase Ib/IIa clinical trial of dantrolene sodium in patients with Wolfram syndrome JCI Insight. 2021;6(15). doi:  
  3. Digenic Variants in the FGF21 Signaling Pathway Associated with Severe Insulin Resistance and Pseudoacromegaly J Endocr Soc. 2020;4(12). doi:  PMCID:PMC7653638  PMID:33210059 
  4. Monogenic and syndromic diabetes due to endoplasmic reticulum stress. J Diabetes Complications. 2020;107618. doi:  PMID:32518033 
  5. Pancreatic stone protein/regenerating protein is a potential biomarker for endoplasmic reticulum stress in beta cells Scientific Reports. 2019. doi:  PMCID:PMC6435683  PMID:30914711 
  6. Severe bilateral adrenal hemorrhages in a newborn complicated by persistent adrenal insufficiency EDM Case Reports. 2018. doi:  PMCID: PMC5820741  PMID:29479447 
  7. Propagation of the [PIN+] prion by fragments of Rnq1 fused to GFP. Curr Genet. 2007;51(5):309-19. doi:10.1007/s00294-007-0127-0  PMCID:PMC2597802  PMID:17415568 
Last updated: 12/05/2022
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