Lori R. Holtz, M.D., M.S.P.H.  loriholtz@wustl.edu

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Founder and Director, The Celiac Center at St. Louis Children’s Hospital
Associate Professor of Pediatrics, Gastroenterology, Hepatology and Nutrition
Gastroenterology, Hepatology and Nutrition

phone: (314) 454-6173

Clinical Interests

Celiac Disease


  • BS, Tulane University1999
  • MD, The Ohio State University College of Medicine2003
  • MSPH, St. Louis University School of Public Health2014


  • Residency, Vanderbilt Children's Hospital2003 - 2006
  • Fellowship, Washington University2006 - 2009

Licensure and Board Certification

  • 2006 - 2026American Board of Pediatrics
  • 2008 - PresMO
  • 2009 - 2023American Board of Pediatrics, Sub-board of Pediatric Gastroenterology

Honors and Awards

  • National Science Scholar1995
  • Tulane University Partial Academic Scholarship1995 - 1999
  • Funding from the National Science Foundation research experience for undergraduates1998
  • Cum Laude, Tulane University1999
  • NASPGHAN travel grant2008
  • Children's Discovery Institute Faculty Scholar2013 - 2018
  • St. Louis Best Doctors2015 - 2020
  • Washington University Institute for Public Health Scholar2016 - Pres
  • March of Dimes Basil O'Connor Award2017 - 2020
  • Doris Duke Clinical Scientist Development Award2017 - 2021

Recent Publications view all (34)

Publication Co-Authors

  1. Longitudinal gut virome analysis identifies specific viral signatures that precede necrotizing enterocolitis onset in preterm infants. Nat Microbiol. 2022. PMID:35449461 
  2. Rhamnose Is Superior to Mannitol as a Monosaccharide in the Dual Sugar Absorption Test: A Prospective Randomized Study in Children With Treatment-Naïve Celiac Disease. Front Pediatr. 2022;10:874116. PMCID:PMC9021878  PMID:35463906 
  3. Viral prevalence by gestational age and season in a large neonatal cord blood cohort. J Matern Fetal Neonatal Med. 2021;1-6. PMID:34587860 
  4. Progression of pediatric celiac disease from potential celiac disease to celiac disease: a retrospective cohort study. BMC Pediatr. 2021;21(1):149. PMID:33781221 
  5. Growth velocity in children with Environmental Enteric Dysfunction is associated with specific bacterial and viral taxa of the gastrointestinal tract in Malawian children. PLoS Negl Trop Dis. 2020;14(6):e0008387. PMID:32574158 
  6. Alphatorquevirus is the most prevalent virus identified in blood from a matched maternal-infant preterm cohort. J Matern Fetal Neonatal Med. 2020;1-7. PMID:32401076 
  7. Prenatal food insecurity post Hurricane Maria is associated with decreased Veillonella in the infant gut. Pediatr Res. 2020. PMID:32172280 
  8. A novel histological index for evaluation of environmental enteric dysfunction identifies geographic-specific features of enteropathy among children with suboptimal growth. PLoS Negl Trop Dis. 2020;14(1):e0007975. PMID:31929525 
  9. Discordant transmission of bacteria and viruses from mothers to babies at birth. Microbiome. 2019;7(1):156. PMID:31823811 
  10. Reply Re: "Amniotic fluid from healthy term pregnancies does not harbor a detectable microbial community". Microbiome. 2019;7(1):21. PMCID:PMC6373012  PMID:30755269 
  11. Amniotic fluid from healthy term pregnancies does not harbor a detectable microbial community. Microbiome. 2018;6(1):87. PMCID:PMC5946436  PMID:29751830 
  12. Case-Control Assessment of the Roles of Noroviruses, Human Bocaviruses 2, 3, and 4, and Novel Polyomaviruses and Astroviruses in Acute Childhood Diarrhea. J Pediatric Infect Dis Soc. 2017;6(3):e49-e54. PMID:28186546 
  13. Propagation of astrovirus VA1, a neurotropic human astrovirus, in cell culture. J Virol. 2017. PMCID:PMC5599743  PMID:28701405 
  14. Statoviruses, A novel taxon of RNA viruses present in the gastrointestinal tracts of diverse mammals. Virology. 2017;504:36-44. PMCID:PMC5515247  PMID:28152382 
  15. Risk Factors Associated with Very Low Birth Weight in a Large Urban Area, Stratified by Adequacy of Prenatal Care. Matern Child Health J. 2016;20(3):623-9. PMID:26537389 
  16. A diverse group of small circular ssDNA viral genomes in human and non-human primate stools. Virus Evol. 2015;1(1):vev017. PMCID:PMC5014484  PMID:27774288 
  17. Early life dynamics of the human gut virome and bacterial microbiome in infants. Nat Med. 2015;21(10):1228-34. PMCID:PMC4710368  PMID:26366711 
  18. Prevalence of classic, MLB-clade and VA-clade Astroviruses in Kenya and The Gambia. Virol J. 2015;12:78. PMCID:PMC4465002  PMID:25975198 
  19. Geographic variation in the eukaryotic virome of human diarrhea. Virology. 2014;468-470:556-64. PMCID:PMC4254309  PMID:25262473 
  20. Seroepidemiology of astrovirus MLB1. Clin Vaccine Immunol. 2014;21(6):908-11. PMCID:PMC4054231  PMID:24789796 
  21. Discovery of rosavirus 2, a novel variant of a rodent-associated picornavirus, in children from The Gambia. Virology. 2014;454-455:25-33. PMCID:PMC4096378  PMID:24725928 
  22. Comparison of novel MLB-clade, VA-clade and classic human astroviruses highlights constrained evolution of the classic human astrovirus nonstructural genes. Virology. 2013;436(1):8-14. PMCID:PMC3545029  PMID:23084422 
  23. Human polyomaviruses in children undergoing transplantation, United States, 2008-2010. Emerg Infect Dis. 2012;18(10):1676-9. PMCID:PMC3471627  PMID:23017293 
  24. Novel astroviruses in children, Egypt. Emerg Infect Dis. 2011;17(12):2391-3. PMCID:PMC3311207  PMID:22172277 
  25. Astrovirus MLB2 viremia in febrile child. Emerg Infect Dis. 2011;17(11):2050-2. PMCID:PMC3310569  PMID:22099095 
  26. Astrovirus MLB1 is not associated with diarrhea in a cohort of Indian children. PLoS One. 2011;6(12):e28647. PMCID:PMC3235140  PMID:22174853 
  27. Serological evidence of human klassevirus infection. Clin Vaccine Immunol. 2010;17(10):1584-8. PMCID:PMC2952992  PMID:20739504 
  28. Detection of novel sequences related to african Swine Fever virus in human serum and sewage. J Virol. 2009;83(24):13019-25. PMCID:PMC2786824  PMID:19812170 
  29. Human stool contains a previously unrecognized diversity of novel astroviruses. Virol J. 2009;6:161. PMCID:PMC2765957  PMID:19814825 
  30. Klassevirus 1, a previously undescribed member of the family Picornaviridae, is globally widespread. Virol J. 2009;6:86. PMCID:PMC2706813  PMID:19552824 
  31. Acute bloody diarrhea: a medical emergency for patients of all ages. Gastroenterology. 2009;136(6):1887-98. PMID:19457417 
  32. Detection of newly described astrovirus MLB1 in stool samples from children. Emerg Infect Dis. 2009;15(3):441-4. PMCID:PMC2666294  PMID:19239759 
  33. Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea. Virol J. 2008;5:159. PMCID:PMC2615758  PMID:19102772 
  34. GH mRNA levels are elevated by forskolin but not GH releasing hormone in GHRH receptor-expressing MtT/S somatotroph cell line. Mol Cell Endocrinol. 2001;172(1-2):125-34. PMID:11165046 
Last updated: 10/31/2022
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