Joshi H, Almgren-Bell A, Anaya EP, Todd EM, Van Dyken SJ, Seth A, McIntire KM, Singamaneni S, Sutterwala F, Morley SC. L-plastin enhances NLRP3 inflammasome assembly and bleomycin-induced lung fibrosis. Cell Rep. 2022;38(11):110507. PMID:35294888 Joshi, H. and S.C. Morley. Efficient T cell Migration and Activation require L-plastin. Frontiers Immunology. 2022.
Anaya EP, Lin X, Todd EM, Szasz TP, Morley SC. Novel Mouse Model Reveals That Serine Phosphorylation of L-Plastin Is Essential for Effective Splenic Clearance of Pneumococcus. J Immunol. 2021;206(9):2135-2145. PMCID:PMC8323710 PMID:33858961 Mantravadi V, Nguyen ST, Morley SC, Bednarski JJ, Kitcharoensakkul M, Cooper MA. Recovery from COVID-19 in a Child with Chronic Granulomatous Disease and T Cell Lymphopenia. J Clin Immunol. 2021;41(1):23-25. PMCID:PMC7588587 PMID:33108551 Bhatlekar S, Manne BK, Basak I, Edelstein LC, Tugolukova E, Stoller ML, Cody MJ, Morley SC, Nagalla S, Weyrich AS, Rowley JW, O'Connell RM, Rondina MT, Campbell RA, Bray PF. miR-125a-5p Regulates Megakaryocyte Proplatelet Formation Via the Actin Bundling Protein L-Plastin. Blood. 2020. PMID:32844999 Gregory MH, Ciorba MA, Wiitala WL, Stidham RW, Higgins P, Morley SC, Hou JK, Feagins LA, Govani SM, Cohen-Mekelburg SA, Waljee AK. The Association of Medications and Vaccination with Risk of Pneumonia in Inflammatory Bowel Disease. Inflamm Bowel Dis. 2020;26(6):919-925. PMCID:PMC7350553 PMID:31504531 Lu X, Kugadas A, Smith-Page K, Lamb J, Lin T, Ru Y, Morley SC, Fichorova R, Mittal SK, Chauhan SK, Littleton S, Saban D, Gadjeva M. Neutrophil L-Plastin Controls Ocular Paucibacteriality and Susceptibility to Keratitis. Front Immunol. 2020;11:547. PMCID:PMC7147296 PMID:32318063 Chellaiah MA, Moorer MC, Majumdar S, Aljohani H, Morley SC, Yingling V, Stains JP. L-Plastin deficiency produces increased trabecular bone due to attenuation of sealing ring formation and osteoclast dysfunction. Bone Res. 2020;8:3. PMCID:PMC6976634 PMID:31993243 Todd EM, Ramani R, Szasz TP, Morley SC. Inhaled GM-CSF in neonatal mice provides durable protection against bacterial pneumonia. Sci Adv. 2019;5(8):eaax3387. PMCID:PMC6693910 PMID:31453341 Joshi H, Morley SC. Cells under stress: The mechanical environment shapes inflammasome responses to danger signals. J Leukoc Biol. 2019. PMID:30645000 Si M, Goodluck H, Zeng C, Pan S, Todd EM, Morley SC, Qin X, Mohan S, Xing W. LRRK1 regulation of actin assembly in osteoclasts involves serine 5 phosphorylation of L-plastin. J Cell Biochem. 2018;119(12):10351-10357. PMCID:PMC6218268 PMID:30136304 Stewart-Hutchinson PJ, Szasz TP, Jaeger ER, Onken MD, Cooper JA, Morley SC. Technical Advance: New in vitro method for assaying the migration of primary B cells using an endothelial monolayer as substrate. J Leukoc Biol. 2017;102(3):941-948. PMCID:PMC5557643 PMID:28637896 McFarland M, Szasz TP, Zhou JY, Motley K, Sivapalan JS, Isaacson-Schmid M, Todd EM, Hogan PG, Fritz SA, Burnham CD, Hoffmann S, Morley SC. Colonization with 19F and other pneumococcal conjugate vaccine serotypes in children in St. Louis, Missouri, USA. Vaccine. 2017;35(34):4389-4395. PMID:28687405 Todd EM, Zhou JY, Szasz TP, Deady LE, D'Angelo JA, Cheung MD, Kim AH, Morley SC. Alveolar macrophage development in mice requires L-plastin for cellular localization in alveoli. Blood. 2016;128(24):2785-2796. doi:10.1182/blood-2016-03-705962 PMCID:PMC5159703 PMID:27758872 Zhou JY, Szasz TP, Stewart-Hutchinson PJ, Sivapalan J, Todd EM, Deady LE, Cooper JA, Onken MD, Morley SC. L-Plastin promotes podosome longevity and supports macrophage motility. Mol Immunol. 2016;78:79-88. PMCID:5205537 PMID:27614263 Xu X, Wang X, Todd EM, Jaeger ER, Vella JL, Mooren OL, Feng Y, Hu J, Cooper JA, Morley SC, Huang YH. Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration. J Immunol. 2016;197(5):1683-91. PMCID:PMC4992580 PMID:27465533 Rosen DA, Hilliard JK, Tiemann KM, Todd EM, Morley SC, Hunstad DA. Klebsiella pneumoniae FimK Promotes Virulence in Murine Pneumonia. J Infect Dis. 2016;213(4):649-58. PMCID:PMC4721909 PMID:26347570 Zhou JY, Isaacson-Schmid M, Utterson EC, Todd EM, McFarland M, Sivapalan J, Niehoff JM, Burnham CD, Morley SC. Prevalence of nasopharyngeal pneumococcal colonization in children and antimicrobial susceptibility profiles of carriage isolates. Int J Infect Dis. 2015;39:50-52. PMCID:PMC4620696 PMID:26327122 Morley SC. HIV-1 Nef drives macrophages into hiding. Blood. 2015;125(10):1512-3. PMID:25745180 Deady LE, Todd EM, Davis CG, Zhou JY, Topcagic N, Edelson BT, Ferkol TW, Cooper MA, Muenzer JT, Morley SC. L-plastin is essential for alveolar macrophage production and control of pulmonary pneumococcal infection. Infect Immun. 2014;82(5):1982-93. doi:10.1128/IAI.01199-13 PMCID:PMC3993441 PMID:24595139 Rodriguez M, Nelson M, Kelly JE, Elward A, Morley SC. Successful use of temocillin as salvage therapy for cervical osteomyelitis secondary to multidrug-resistant Burkholderia cepacia. J Ped Infect Dis. 2014;3(1):77-80.
Morley SC. The actin-bundling protein L-plastin supports T-cell motility and activation. Immunol Rev. 2013;256(1):48-62. PMCID:PMC3801223 PMID:24117812 Todd EM, Deady LE, Morley SC. Intrinsic T- and B-cell defects impair T-cell-dependent antibody responses in mice lacking the actin-bundling protein L-plastin. Eur J Immunol. 2013;43(7):1735-44. PMCID:PMC3794664 PMID:23589339 Watson Jr M E, Morley SC. Streptococcus Intermedius Brain Abscesses in an Adolescent Male with Histoplasma Infection. Pediatric Oncall [serial online] 2012 [cited 2012 October 1]; 9. Art # 62. Available from: http://www.pediatriconcall.com/fordoctor/casereports/BrainAbscesses.asp 2012.
Morley SC. The actin-bundling protein L-plastin: a critical regulator of immune cell function. Int J Cell Biol. 2012;2012:935173. PMCID:PMC3238366 PMID:22194750 Wang C, Morley SC, Donermeyer D, Peng I, Lee WP, Devoss J, Danilenko DM, Lin Z, Zhang J, Zhou J, Allen PM, Brown EJ. Actin-bundling protein L-plastin regulates T cell activation. J Immunol. 2010;185(12):7487-97. doi:10.4049/jimmunol.1001424 PMCID:PMC3027212 PMID:21076065 Morley SC, Wang C, Lo WL, Lio CW, Zinselmeyer BH, Miller MJ, Brown EJ, Allen PM. The actin-bundling protein L-plastin dissociates CCR7 proximal signaling from CCR7-induced motility. J Immunol. 2010;184(7):3628-38. doi:10.4049/jimmunol.0903851 PMCID:PMC2855624 PMID:20194718 Wambach J, Morley SC. Visual Diagnosis: Skin Ulcerations in a Preterm Newborn NeoReviews. 2009;10:e575.
Morley SC, Weber KS, Kao H, Allen PM. Protein kinase C-theta is required for efficient positive selection. J Immunol. 2008;181(7):4696-708. PMCID:PMC2645034 PMID:18802072 Morley SC, Allen PM. Taking a toll road to better vaccines. Immunity. 2008;28(5):602-4. PMID:18482564 Morley SC, Sung J, Sun GP, Martelli MP, Bunnell SC, Bierer BE. Gelsolin overexpression alters actin dynamics and tyrosine phosphorylation of lipid raft-associated proteins in Jurkat T cells. Mol Immunol. 2007;44(9):2469-80. doi:10.1016/j.molimm.2006.09.024 PMCID:PMC1945820 PMID:17178161 Celeste Morley S, Sun GP, Bierer BE. Inhibition of actin polymerization enhances commitment to and execution of apoptosis induced by withdrawal of trophic support. J Cell Biochem. 2003;88(5):1066-76. doi:10.1002/jcb.10449 PMID:12616543 Morley SC, Bierer BE. The actin cytoskeleton, membrane lipid microdomains, and T cell signal transduction. Adv Immunol. 2001;77:1-43. PMID:11293114 Posey SC, Martelli MP, Azuma T, Kwiatkowski DJ, Bierer BE. Failure of gelsolin overexpression to regulate lymphocyte apoptosis. Blood. 2000;95(11):3483-8. PMID:10828033 Posey SC, Bierer BE. Actin stabilization by jasplakinolide enhances apoptosis induced by cytokine deprivation. J Biol Chem. 1999;274(7):4259-65. PMID:9933626 Palanivel V, Posey C, Horauf AM, Solbach W, Piessens WF, Harn DA. B-cell outgrowth and ligand-specific production of IL-10 correlate with Th2 dominance in certain parasitic diseases. Exp Parasitol. 1996;84(2):168-77. doi:10.1006/expr.1996.0102 PMID:8932766 Todd EM, Ramani R, Szasz TP, Morley SC. Inhaled GM-CSF in neonatal mice provides durable protection against bacterial pneumonia. Sci. Adv.