David A. Rudnick, M.D., Ph.D.  rudnick_d@wustl.edu

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Associate Professor of Pediatrics, Gastroenterology, Hepatology and Nutrition
Researcher, Developmental Biology
Gastroenterology, Hepatology and Nutrition

phone: (314) 454-6173

Clinical Interests

I am board certified in pediatrics and pediatric gastroenterology, and I have >15 years of experience caring for patients with a wide range of pediatric GI, liver and pancreatic diseases.


  • BS, University of Illinois1987
  • MD, Washington University School of Medicine1994
  • PhD, Washington University School of Medicine 1994


  • Internship, St. Louis Children's Hospital1994 - 1995
  • Residency, St. Louis Children's Hospital1995 - 1997
  • Fellowship, Washington University School of Medicine1997 - 2000

Licensure and Board Certification

  • 1997 - PresMO
  • 1997American Board of Pediatrics, General Pediatrics
  • 2001American Board of Pediatrics, Sub-board of Pediatric Gastroenterology
  • 2004 - PresAmerican Board of Pediatrics, General Pediatrics, Recertification
  • 2008 - PresAmerican Board of Pediatrics, Sub-board of Pediatric Gastroenterology, Recertification

Honors and Awards

  • Phi Beta Kappa, University of Illinois Chapter1987
  • Summa Cum Laude, University of Illinois1987
  • American Federation for Clinical Research, Medical Student Award, Washington University Medical School1992
  • Spencer T. and Ann W. Olin Foundation Medical Scientist Predoctoral, Fellowship, Washington University Medical School1992
  • American College of Physicians Award for Excellence in Physical Diagnosis, Washington University Medical School1993
  • Alpha Omega Alpha, Washington University Medical School Chapter1994
  • The Dr. Phillip Needleman Pharmacology Award, Washington University Medical School1994
  • The George F. Gill Prize in Pediatrics, Washington University Medical School1994
  • Scholar of the Child Health Research Center for Excellence in Developmental Biology at Washington University Medical School2000 - 2003
  • NASPGHAN Young Faculty Investigator Award2003
  • Research Excellence in GI and Liver (REGAL) Award2003
  • Best Doctors in America2007 - Pres
  • WUMS Distinguished Investigator Award2008
  • NASPGHAN Foundation Mid-Level Career Development Award2015

Recent Publications view all (55)

Publication Co-Authors

  1. Outcomes Analyses of Pediatric Acute Liver Failure Subjects listed for Liver Transplantation JPGN. 2022;74(6):750-756. doi:DOI: 10.1097/MPG.0000000000003448  PMCID:PMC9296584  PMID:35442235 
  2. Regulation of PGC1α downstream of the insulin signaling pathway plays a role in the hepatic proteotoxicity of mutant α1-antitrypsin deficiency variant Z. Gastroenterology. 2022. PMID:35301011 
  3. GATA6 modulates the ductular reaction to bile duct ligation. Hepatol Int. 2021;15(1):166-178. PMID:33486744 
  4. Diet Modifies Pioglitazone's Influence on Hepatic PPARγ-Regulated Mitochondrial Gene Expression. PPAR Res. 2020;2020:3817573. PMCID:PMC7501566  PMID:32963510 
  5. Invasive Ductular Reaction: Form and Function. Am J Pathol. 2019;189(8):1501-1504. PMID:31202722 
  6. Liver Transplant Listing in Pediatric Acute Liver Failure: Practices and Participant Characteristics. Hepatology. 2018;68(6):2338-2347. PMCID:PMC6275095  PMID:30070372 
  7. Transcription factor GATA6: a novel marker and putative inducer of ductal metaplasia in biliary atresia. Am J Physiol Gastrointest Liver Physiol. 2018;314(5):G547-G558. doi:doi: 10.1152/ajpgi.00362.2017.  PMID:29388792 
  8. Health Related Quality of Life and Neurocognitive Outcomes in the First Year after Pediatric Acute Liver Failure. J Pediatr. 2018;196:129-138.e3. PMCID:PMC5933443  PMID:29551316 
  9. Induced Pluripotent Stem Cell-Derived Hepatocytes and Precision Medicine in Human Liver Disease. J Pediatr Gastroenterol Nutr. 2018;66(5):716-719. PMID:29509632 
  10. A Learning Collaborative Approach Increases Specificity of Diagnosis of Acute Liver Failure in Pediatric Patients. Clin Gastroenterol Hepatol. 2018;Epub ahead of print](doi: 10.1016/j.cgh.2018.04.050.):pii: S1542-3565(18)30455-5.. PMID:29723692 
  11. Antifibrotic therapies in liver disease: Ready for primetime? Clin Liver Dis (Hoboken). 2017;9(6):138-140. PMCID:PMC6467161  PMID:30992978 
  12. Prevalence and Significance of Autoantibodies in Children With Acute Liver Failure. J Pediatr Gastroenterol Nutr. 2017;64(2):210-217. PMCID:PMC5250572  PMID:27496798 
  13. Outcomes of Children With and Without Hepatic Encephalopathy From the Pediatric Acute Liver Failure Study Group. J Pediatr Gastroenterol Nutr. 2016;63(3):357-64. PMCID:PMC4992416  PMID:27367788 
  14. Clinical Course among Cases of Acute Liver Failure of Indeterminate Diagnosis. J Pediatr. 2016;171:163-70.e1-3. PMCID:PMC4808594  PMID:26831743 
  15. Postponing the Hypoglycemic Response to Partial Hepatectomy Delays Mouse Liver Regeneration. Am J Pathol. 2016;186(3):587-99. doi:10.1016/j.ajpath.2015.10.027  PMID:26772417 
  16. Dietary aflatoxin-induced stunting in a novel rat model: evidence for toxin-induced liver injury and hepatic growth hormone resistance. Pediatr Res. 2015;78(2):120-127. doi:10.1038/pr.2015.84  PMCID:PMC4506701  PMID:25938735 
  17. Baseline Analysis of a Young α-1-Antitrypsin Deficiency Liver Disease Cohort Reveals Frequent Portal Hypertension. J Pediatr Gastroenterol Nutr. 2015;61(1):94-101. doi:10.1097/MPG.0000000000000753  PMID:25651489 
  18. Analysis of viral testing in nonacetaminophen pediatric acute liver failure. J Pediatr Gastroenterol Nutr. 2014;59(5):616-23. PMCID:PMC4305349  PMID:25340974 
  19. Fibroblast growth factor 15 deficiency impairs liver regeneration in mice. Am J Physiol Gastrointest Liver Physiol. 2014;306(10):G893-902. doi:10.1152/ajpgi.00337.2013  PMCID:PMC4024724  PMID:24699334 
  20. Elucidating the metabolic regulation of liver regeneration. Am J Pathol. 2014;184(2):309-21. PMCID:PMC3906487  PMID:24139945 
  21. Identification of an epigenetic signature of early mouse liver regeneration that is disrupted by Zn-HDAC inhibition. Epigenetics. 2014;9(11):1521-31. doi:10.4161/15592294.2014.983371  PMID:25482284 
  22. Pregnancy in an NTBC-treated patient with hereditary tyrosinemia type I. J Pediatr Gastroenterol Nutr. 2013. doi:10.1097/MPG.0b013e3182a27463  PMID:23838819 
  23. Characterization of the regulation and function of zinc-dependent histone deacetylases during rodent liver regeneration. Hepatology. 2013;57(5):1742-51. doi:10.1002/hep.26206  PMID:23258575 
  24. Intravenous N-acetylcysteine in pediatric patients with nonacetaminophen acute liver failure: a placebo-controlled clinical trial. Hepatology. 2013;57(4):1542-9. doi:10.1002/hep.26001  PMCID:PMC3509266  PMID:22886633 
  25. Chronic acetaminophen exposure in pediatric acute liver failure. Pediatrics. 2013;131(3):e740-6. PMCID:PMC3581836  PMID:23439908 
  26. Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure. PLoS One. 2013;8(11):e78202. doi:10.1371/journal.pone.0078202  PMCID:PMC3823926  PMID:24244295 
  27. Analysis of the role of hepatic PPARγ expression during mouse liver regeneration. Hepatology. 2012;56(4):1489-98. doi:10.1002/hep.25880  PMCID:PMC3465497  PMID:22707117 
  28. The influence of skeletal muscle on the regulation of liver:body mass and liver regeneration. Am J Pathol. 2012;180(2):575-82. doi:10.1016/j.ajpath.2011.10.032  PMCID:PMC3349872  PMID:22155110 
  29. Functional Relationships between Lipid Metabolism and Liver Regeneration. Int J Hepatol. 2012;2012:549241. PMCID:PMC3272806  PMID:22319652 
  30. Liver regeneration is impaired in lipodystrophic fatty liver dystrophy mice. Hepatology. 2010;52(6):2109-17. doi:10.1002/hep.23920  PMCID:PMC2991544  PMID:20967828 
  31. Rapamycin reduces intrahepatic alpha-1-antitrypsin mutant Z protein polymers and liver injury in a mouse model Exp Biol Med (Maywood). 2010;235(6):700-709. PMID:20511674 
  32. Characteristics of hepatocellular carcinoma in a murine model of alpha-1-antitrypsin deficiency. Hepatol Res. 2010;40(6):641-53. doi:10.1111/j.1872-034X.2010.00663.x  PMCID:PMC2928671  PMID:20618460 
  33. Dyskerin ablation in mouse liver inhibits rRNA processing and cell division. Mol Cell Biol. 2010;30(2):413-22. doi:10.1128/MCB.01128-09  PMCID:PMC2798470  PMID:19917719 
  34. Murine functional liver mass is reduced following partial small bowel resection. J Gastrointest Surg. 2009;13(12):2176-82. doi:10.1007/s11605-009-1043-z  PMCID:PMC3034449  PMID:19774425 
  35. p21 is required for dextrose-mediated inhibition of mouse liver regeneration Hepatology. 2009;50(1):207-215. PMCID:PMC2705473   PMID:19441104 
  36. Serum alpha-NH-butyric acid may predict spontaneous survival in pediatric acute liver failure. Pediatr Transplant. 2009;13(2):223-30. doi:10.1111/j.1399-3046.2008.00998.x  PMCID:PMC2659723  PMID:18643912 
  37. Evidence for non-traditional activation of complement factor C3 during murine liver regeneration. Mol Immunol. 2008;45(11):3125-32. doi:10.1016/j.molimm.2008.03.008  PMCID:PMC2600895  PMID:18452991 
  38. Rosiglitazone inhibits mouse liver regeneration. FASEB J. 2006;20(14):2609-11. doi:10.1096/fj.06-6511fje  PMID:17077279 
  39. Indomethacin increases liver damage in a murine model of liver injury from alpha-1-antitrypsin deficiency. Hepatology. 2006;44(4):976-82. doi:10.1002/hep.21326  PMID:17006946 
  40. Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice. Hepatology. 2004;40(6):1322-32. doi:10.1002/hep.20462  PMID:15565660 
  41. Delayed hepatocellular mitotic progression and impaired liver regeneration in early growth response-1-deficient mice. J Biol Chem. 2004;279(41):43107-16. doi:10.1074/jbc.M407969200  PMID:15265859 
  42. Analyses of hepatocellular proliferation in a mouse model of alpha-1-antitrypsin deficiency. Hepatology. 2004;39(4):1048-55. doi:10.1002/hep.20118  PMID:15057909 
  43. Protection from pancreatitis by the zymogen granule membrane protein integral membrane-associated protein-1. J Biol Chem. 2002;277(52):50725-33. doi:10.1074/jbc.M204159200  PMID:12401800 
  44. Prostaglandins are required for CREB activation and cellular proliferation during liver regeneration. Proc Natl Acad Sci U S A. 2001;98(15):8885-90. doi:10.1073/pnas.151217998  PMCID:PMC37530  PMID:11447268 
  45. Use of photoactivatable peptide substrates of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase (Nmt1p) to characterize a myristoyl-CoA-Nmt1p-peptide ternary complex and to provide evidence for an ordered reaction mechanism. Proc Natl Acad Sci U S A. 1993;90(3):1087-91. PMCID:PMC45816  PMID:8430078 
  46. Genetic and biochemical studies of a mutant Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase, nmt72pLeu99-->Pro, that produces temperature-sensitive myristic acid auxotrophy. J Biol Chem. 1993;268(1):483-94. PMID:8416952 
  47. Studies of the catalytic activities and substrate specificities of Saccharomyces cerevisiae myristoyl-coenzyme A: protein N-myristoyltransferase deletion mutants and human/yeast Nmt chimeras in Escherichia coli and S. cerevisiae. J Biol Chem. 1992;267(33):23852-61. PMID:1429724 
  48. Analogs of palmitoyl-CoA that are substrates for myristoyl-CoA:protein N-myristoyltransferase. Proc Natl Acad Sci U S A. 1992;89(21):10507-11. PMCID:PMC50368  PMID:1438240 
  49. Substrate specificity of Saccharomyces cerevisiae myristoyl-CoA: protein N-myristoyltransferase. Analysis of fatty acid analogs containing carbonyl groups, nitrogen heteroatoms, and nitrogen heterocycles in an in vitro enzyme assay and subsequent identification of inhibitors of human immunodeficiency virus I replication. J Biol Chem. 1992;267(11):7224-39. PMID:1559967 
  50. Analyzing the substrate specificity of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase by co-expressing it with mammalian G protein alpha subunits in Escherichia coli. J Biol Chem. 1991;266(16):10498-504. PMID:1903791 
  51. Myristic acid auxotrophy caused by mutation of S. cerevisiae myristoyl-CoA:protein N-myristoyltransferase. J Cell Biol. 1991;113(6):1313-30. PMCID:PMC2289034  PMID:2045414 
  52. Kinetic and structural evidence for a sequential ordered Bi Bi mechanism of catalysis by Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase. J Biol Chem. 1991;266(15):9732-9. PMID:2033063 
  53. Protein N-myristoylation. J Biol Chem. 1991;266(14):8647-50. PMID:2026581 
  54. The substrate specificity of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase. Analysis of myristic acid analogs containing oxygen, sulfur, double bonds, triple bonds, and/or an aromatic residue. J Biol Chem. 1991;266(14):8835-55. PMID:2026598 
  55. Structural and functional studies of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase produced in Escherichia coli. Evidence for an acyl-enzyme intermediate. J Biol Chem. 1990;265(22):13370-8. PMID:2198291 
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