Charles Samson, M.D.

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Associate Professor of Pediatrics, Gastroenterology, Hepatology and Nutrition
Fellowship Program Director, Pediatric Gastroenterology, Hepatology and Nutrition
Director, Washington University Pediatric and Adolescent Inflammatory Bowel Disease Center at St Louis Children's Hospital
Gastroenterology, Hepatology and Nutrition

phone: (314) 454-6173

Clinical Interests

Pediatric inflammatory bowel disease and general pediatric gastrointestinal illness


  • BS, Highest Distinction and Highest Honors, University of North Carolina at Chapel Hill1998
  • MD, Thesis Honors, University of Washington2003


  • Pediatric Residency, Univeristy of North Carolina at Chapel Hill/NC Children's Hospital2003 - 2006
  • Pediatric Gastroenterology Fellowship, Cincinnati Children's Hospital Medical Center2006 - 2009
  • Advanced Improvement Methods Workshop, Cincinnati Children's Hospital Medical Center2014 - 2015
  • Pediatric Leadership Development Program, Washington University School of Medicine2016 - 2016
  • Academic Medical Leadership Program for Physicians & Scientists, Washington University School of Medicine, Washington University Olin Business School, & BJC Healthcare2018 - 2018
  • Educational Skills Program, Washington University School of Medicine2018 - 2019
  • EPIC Physician Builder Certificate 2021 - 2021

Licensure and Board Certification

  • 2003 - 2006NC, NC Training License
  • 2006 - 2009OH, Ohio Training Certificate
  • 2006 - PresAmerican Board of Pediatrics; General Pediatrics
  • 2009 - 2012OH, Ohio Medical License
  • 2009 - PresAmerican Board of Pediatrics; Pediatric Gastroenterology
  • 2011 - PresMO, Missouri Medical License
  • 2016 - 2019AR, Arkansas Medical License
  • 2020 - PresIL, Illinois Medical License

Honors and Awards

  • David L Stern Award; Department of Chemistry; University of North Carolina at Chapel Hill1997
  • Phi Beta Kappa; University of North Carolina at Chapel Hill1997
  • Highest Distinction Graduate; University of North Carolina at Chapel Hill1998
  • Highest Honor's Thesis in Chemistry; University of North Carolina at Chapel Hill1998
  • Venable Medal; Department of Chemistry; University of North Carolina at Chapel Hill1998
  • Medical Thesis Honors; University of Washington School of Medicine2002
  • Fellowship to Faculty Transition Award; Foundation of the American Gastroenterological Association2009
  • Pediatric Loan Repayment Award; National Institutes of Health2009
  • Procter Scholar Award; Cincinnati Children's Hospital Medical Center2009
  • Poster of Distinction, Digestive Disease Week2011

Recent Publications view all (27)

Publication Co-Authors

  1. Immunosuppressant-associated eruptions in pediatric inflammatory bowel disease: A case-control study. Pediatr Dermatol. 2022;39(4):563-566. PMID:35342990 
  2. Very-Early Onset Chronic Active Colitis with Heterozygous Variants in LRBA1 and CARD11, a Case of "Immune TOR-Opathies" Fetal Pediatr Pathol. 2022. doi:10.1080/15513815.2022.2088912  PMID:35748740 
  3. Use of Patient-Reported Outcomes Measurement Information System Pediatric Measures as Clinical Trial Endpoints: Experience from a Multicenter Pragmatic Trial in Children with Crohn's Disease. J Pediatr. 2022;242:86-92.e3. PMCID:PMC8882140  PMID:34740588 
  4. Evaluation of Nonalcoholic Fatty Liver Disease in Pediatric Patients With Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr. 2021;72(4):574-578. PMID:33346578 
  5. Continued Statural Growth in Older Adolescents and Young Adults With Crohn's Disease and Ulcerative Colitis Beyond the Time of Expected Growth Plate Closure. Inflamm Bowel Dis. 2020;26(12):1880-1889. PMID:31968095 
  6. Development and evaluation of an EHR‐based computable phenotype for identification of pediatric Crohn's disease patients in a National Pediatric Learning Health System. Learning Health Systems. 2020;4:e10243. doi:  
  7. Implementing a Novel Quality Improvement-Based Approach to Data Quality Monitoring and Enhancement in a Multipurpose Clinical Registry. EGEMS (Wash DC). 2019;7(1):51. PMCID:PMC6777196  PMID:31646151 
  8. Reduction of Computed Tomography Use for Pediatric Closed Head Injury Evaluation at a Nonpediatric Community Emergency Department Acad Emerg Med. 2018;e pub. PMID:30428150 
  9. Accuracy of the medication list in the electronic health record-implications for care, research, and improvement. J Am Med Inform Assoc. 2018;25(7):909-912. PMID:29771350 
  10. The Use of Concomitant Immunomodulators with Adalimumab Therapy in Pediatric Crohn's Disease J Clin Cell Immunol. 2018;9(1):e pub. 
  11. Rapid Infliximab Infusion in Children with Inflammatory Bowel Disease: A Multicenter North American Experience. Inflamm Bowel Dis. 2017;23(12):2104-2108. PMID:29140940 
  12. Serologic Evidence of Gut-driven Systemic Inflammation in Juvenile Idiopathic Arthritis J Rheum. 2017;44(11):1624-31. PMID:28916545 
  13. Application of Conjoint Analysis to Improve Reliability of Dietician Consultation in Pediatric Celiac Disease. Pediatr Qual Saf. 2017;2(4):e029. PMCID:PMC6132477  PMID:30229166 
  14. Remission in Pediatric Inflammatory Bowel Disease Correlates With Prescription Refill Adherence Rates. J Pediatr Gastroenterol Nutr. 2017;64(4):575-579. PMID:27299424 
  15. Improved outcomes with quality improvement interventions in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2012;55(6):679-88. PMID:22699837 
  16. Budesonide use in pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2012;55(2):200-4. PMID:22258289 
  17. Improved outcomes in a quality improvement collaborative for pediatric inflammatory bowel disease. Pediatrics. 2012;129(4):e1030-41. PMCID:PMC3313634  PMID:22412030 
  18. Granulocyte-macrophage colony stimulating factor blockade promotes ccr9(+) lymphocyte expansion in Nod2 deficient mice. Inflamm Bowel Dis. 2011;17(12):2443-55. PMCID:PMC3111853  PMID:21381154 
  19. Outcome following thiopurine use in children with ulcerative colitis: a prospective multicenter registry study. Am J Gastroenterol. 2011;106(5):981-7. PMID:21224840 
  20. Presentation and outcome of histoplasmosis in pediatric inflammatory bowel disease patients treated with antitumor necrosis factor alpha therapy: a case series. Inflamm Bowel Dis. 2011;17(1):56-61. PMID:20645322 
  21. Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury. Gut. 2010;59(8):1066-78. PMCID:PMC4296557  PMID:20584783 
  22. Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease. Gastroenterology. 2009;136(4):1261-71, e1-3. PMID:19230854 
  23. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. J Hepatol. 2004;40(6):942-51. PMID:15158334 
  24. TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein. Surgery. 2004;135(6):619-28. PMID:15179368 
  25. Cirrhotic hepatocytes exhibit decreased TGFbeta growth inhibition associated with downregulated Smad protein expression. Biochem Biophys Res Commun. 2004;313(3):546-51. PMID:14697224 
  26. NFkappaB inhibition decreases hepatocyte proliferation but does not alter apoptosis in obstructive jaundice. J Surg Res. 2003;114(2):110-7. PMID:14559434 
  27. Transforming growth factor-beta1 induces hepatocyte apoptosis by a c-Jun independent mechanism. Surgery. 2002;132(3):441-9. PMID:12324757 
Last updated: 10/31/2022
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