Laura Schuettpelz, M.D, Ph.D.

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Assistant Professor of Pediatrics, Hematology and Oncology
School of MedicineDepartment of MedicineHematology and Oncology



  • BS, Summa Cum Laude, Creighton University1995
  • PhD, Northwestern University2000
  • MD, Northwestern University2005


  • Residency in Pediatrics, Washington Univeristy School of Medicine2005 - 2008
  • Fellowship in Pediatric Hematology/Oncology, Washington University School of Medicine2008 - 2011

Licensure and Board Certification

  • 2005 - PresMO, Missouri Medical License
  • 2009 - PresGeneral Pediatrics
  • 2013 - PresPediatric Hematology/Oncology

Honors and Awards

  • David Gilstrap Award2008
  • James P.Keating Oustanding Resident Award2008
  • Outstanding Fellow Teaching Award2009
  • Scholar of the Child Health Research Center of Excellence in Developmental Biology2012 - Pres
  • Faculty Scholar Award, Children's Discovery Institute of Washington University2013 - Pres

Recent Publications view all (34)

  1. Toll-like receptor and cytokine expression throughout the bone marrow differs between patients with low- and high-risk myelodysplastic syndromes. Exp Hematol. 2022;110:47-59. PMID:35367529 
  2. Microbiota Signals Suppress B Lymphopoiesis With Aging in Mice. Front Immunol. 2021;12:767267. PMCID:PMC8560790  PMID:34737755 
  3. Clonal hematopoiesis in CIN. Blood. 2021;138(14):1204-1206. PMID:34618005 
  4. Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders. Science. 2021;373(6553). PMID:34083450 
  5. Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma. Science. 2021;373(6553). PMID:34083447 
  6. Toll-Like Receptor Signaling in the Establishment and Function of the Immune System. Cells. 2021;10(6). PMCID:PMC8228919  PMID:34199501 
  7. Immunodeficiency and bone marrow failure with mosaic and germline TLR8 gain of function. Blood. 2021;137(18):2450-2462. PMCID:PMC8109013  PMID:33512449 
  8. Open conformation of tetraspanins shapes interaction partner networks on cell membranes. EMBO J. 2020;39(18):e105246. PMCID:PMC7507038  PMID:32974937 
  9. TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse model of MDS. Exp Hematol. 2020. PMID:32652111 
  10. Contribution of Aberrant Toll Like Receptor Signaling to the Pathogenesis of Myelodysplastic Syndromes. Front Immunol. 2020;11:1236. PMCID:PMC7313547  PMID:32625214 
  11. The Tetraspanin CD53 Regulates Early B Cell Development by Promoting IL-7R Signaling. J Immunol. 2020;204(1):58-67. PMCID:PMC6926393  PMID:31748347 
  12. Pediatric Acute Lymphoblastic Leukemia, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2020;18(1):81-112. PMID:31910389 
  13. Trauma Induces Emergency Hematopoiesis through IL-1/MyD88-Dependent Production of G-CSF. J Immunol. 2019;202(10):3020-3032. PMCID:PMC6504560  PMID:30988118 
  14. Rapid development of pulmonary hypertension during treatment of paediatric cancer. Cardiol Young. 2019;29(3):286-289. doi:10.1017/S1047951118002196  PMID:30678742 
  15. NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages. Blood. 2018. PMID:29618478 
  16. Loss of toll-like receptor 2 results in accelerated leukemogenesis in the NUP98-HOXD13 mouse model of MDS. Blood. 2018. PMID:29358180 
  17. Editorial: Inflammatory Signaling in Bone Marrow Failure and Hematopoietic Malignancy. Front Immunol. 2017;8:660. PMCID:PMC5454062  PMID:28626462 
  18. Continuous blockade of CXCR4 results in dramatic mobilization and expansion of hematopoietic stem and progenitor cells. Blood. 2017. PMID:28400375 
  19. The Role of Toll-Like Receptors in Hematopoietic Malignancies. Front Immunol. 2016;7:390. PMCID:PMC5039188  PMID:27733853 
  20. Systemic TLR2 agonist exposure regulates hematopoietic stem cells via cell-autonomous and cell-non-autonomous mechanisms. Blood Cancer J. 2016;6:e437. PMID:27315114 
  21. Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines. Stem Cell Reports. 2016;6(6):806-14. PMCID:PMC4911494  PMID:27185281 
  22. G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling. Leukemia. 2014;28(9):1851-60. doi:10.1038/leu.2014.68  PMCID:PMC4130805  PMID:24518205 
  23. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature. 2013;495(7440):227-30. doi:10.1038/nature11926  PMCID:PMC3600148  PMID:23434756 
  24. Regulation of hematopoietic stem cell activity by inflammation. Front Immunol. 2013;4:204. doi:10.3389/fimmu.2013.00204  PMCID:PMC3715736  PMID:23882270 
  25. Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function. Blood. 2012;120(15):2981-9. doi:10.1182/blood-2012-02-409839  PMCID:PMC3471512  PMID:22936656 
  26. Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML. JAMA. 2011;305(15):1568-76. doi:10.1001/jama.2011.473  PMCID:PMC3170052  PMID:21505135 
  27. Niche competition and cancer metastasis to bone. J Clin Invest. 2011;121(4):1253-5. doi:10.1172/JCI57229  PMCID:PMC3069798  PMID:21436576 
  28. Pilocytic astrocytoma in a child with Noonan syndrome. Pediatr Blood Cancer. 2009;53(6):1147-9. doi:10.1002/pbc.22193  PMID:19621452 
  29. Severe ceftriaxone-induced hemolysis complicated by diffuse cerebral ischemia in a child with sickle cell disease. J Pediatr Hematol Oncol. 2009;31(11):870-2. doi:10.1097/MPH.0b013e3181b7eda2  PMID:19829151 
  30. Upregulation of FasL by LPA on ovarian cancer cell surface leads to apoptosis of activated lymphocytes. Gynecol Oncol. 2004;95(3):488-95. doi:10.1016/j.ygyno.2004.07.052  PMID:15581951 
  31. Proinvasive properties of ovarian cancer ascites-derived membrane vesicles. Cancer Res. 2004;64(19):7045-9. doi:10.1158/0008-5472.CAN-04-1800  PMID:15466198 
  32. RNA-Regulated TRA-1 nuclear export controls sexual fate. Dev Cell. 2001;1(4):539-51. PMID:11703944 
  33. TRA-1 regulates the cellular distribution of the tra-2 mRNA in C. elegans. Nature. 1999;399(6738):802-5. doi:10.1038/21682  PMID:10391248 
  34. The STAR protein, GLD-1, is a translational regulator of sexual identity in Caenorhabditis elegans. EMBO J. 1999;18(1):258-69. doi:10.1093/emboj/18.1.258  PMCID:PMC1171120  PMID:9878068 
Last updated: 08/16/2022
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