Amjad Horani, M.D.  horani_a@wustl.edu

Assistant Professor of Pediatrics, Allergy, Immunology and Pulmonary Medicine
Allergy, Immunology and Pulmonary MedicinePathobiology

phone: (314) 454-2694

Clinical Interests

Dr.Horani is a member of the Division of Allergy, Immunology and Pulmonary Medicine. He was born in Israel and received his medical degree from the Hebrew University of Jerusalem. Dr. Horani completed a residency in Pediatrics at the Hadassah-Hebrew University Medical Center in Jerusalem between 2004 and 2009, and then pursued a fellowship in Pediatric Pulmonology at Washington University School of Medicine in St. Louis before joining the faculty of Washington University in 2014. Dr. Horani's clinical interests include early childhood lung disease, cystic fibrosis, primary ciliary dyskinesia, and asthma.Dr. Horani's main research interest focuses on airway epithelial cell pathogensis including primary ciliary dyskinesia (PCD), a genetic condition that results in impaired mucociliary clearance, causing progressive involvement of the respiratory tract characterized by recurrent infections of the lungs, middle ear, and paranasal sinuses. Dr. Horani is the recipient of multiple scientific awards related to his work in pediatric research. Working alongside members of a multidisciplinary team at Washington University in St. Louis, Dr. Horani's work in the laboratory examines the importance of different genes in the pathogenesis of primary ciliary dyskinesia and studies the function of several proteins in the assembly of motile cilia, a structure known to be defective in PCD.

Education

  • B.Sc., with distinction, The Hebrew University of Jerusalem1999
  • M.D., The Hebrew University of Jerusalem2004

Training

  • Pediatric Residency, Hadassah-Hebrew University Medical Center2004 - 2009
  • Fellowship in Pulmonary Medicine, St. Louis Children's Hospital2010 - 2013
  • Advanced fellowship in Pediatric Pulmonary Medicine, St. Louis Children's Hospital2013 - 2014

Licensure and Board Certification

  • Israeli Medical License2004
  • Israeli Board of Pediatrics2009
  • MO, Missouri Medical License2014
  • Israeli Board of Pediatric Pulmonary Medicine2015

Honors

  • Excellent clinical Teacher, Department of Pediatrics, Hadassah-Hebrew University Medical Center.2005
  • Excellent clinical Teacher, Department of Pediatrics, Hadassah-Hebrew University Medical Center.2006
  • Dr. BOYKES Honorary award for excellent Pediatric Research, Israeli Association of Clinical Pediatrics2007
  • Young Clinician Award, Hadassah-Hebrew University Medical Center2008
  • Dr. DIMSON Honorary Faculty award for excellent Pediatric Research, The Hebrew University-Hadassah Faculty of Medicine2008
  • Best fellows abstract, pediatric research retreat, Washington University in St. Louis2012
  • Martin K. and Jill F. Sneider Endowed Fellowship Award2013
  • Annual ATS Assembly on Pediatrics Scientific Award2013
  • The Japanese Respiratory Society International Session Award2014
  • Gordon conference Abstract Award2015

Recent Publications view all (27)


Publication Co-Authors

  1. Horani A, Ferkol TW. Primary ciliary dyskinesia and associated sensory ciliopathies. Expert Rev Respir Med. 2016;10(5):569-76. doi:10.1586/17476348.2016.1165612  PMCID:PMC4893162  PMID:26967669  
  2. Horani A, Ferkol TW, Dutcher SK, Brody SL. Genetics and biology of primary ciliary dyskinesia. Paediatr Respir Rev. 2015. doi:10.1016/j.prrv.2015.09.001  PMID:26476603  
  3. Horani A, Brody SL, Ferkol TW. Picking up speed: advances in the genetics of primary ciliary dyskinesia. Pediatr Res. 2014;75(1-2):158-64. doi:10.1038/pr.2013.200  PMCID:PMC3946436  PMID:24192704  
  4. Ghadially H, Horani A, Glasner A, Elboim M, Gazit R, Shoseyov D, Mandelboim O. NKp46 regulates allergic responses. Eur J Immunol. 2013;43(11):3006-16. doi:10.1002/eji.201343388  PMCID:PMC3867659  PMID:23878025  
  5. Horani A, Nath A, Wasserman MG, Huang T, Brody SL. Rho-associated protein kinase inhibition enhances airway epithelial Basal-cell proliferation and lentivirus transduction. Am J Respir Cell Mol Biol. 2013;49(3):341-7. doi:10.1165/rcmb.2013-0046TE  PMCID:PMC3824057  PMID:23713995  
  6. Horani A, Brody SL, Ferkol TW, Shoseyov D, Wasserman MG, Ta-shma A, Wilson KS, Bayly PV, Amirav I, Cohen-Cymberknoh M, Dutcher SK, Elpeleg O, Kerem E. CCDC65 mutation causes primary ciliary dyskinesia with normal ultrastructure and hyperkinetic cilia. PLoS One. 2013;8(8):e72299. doi:10.1371/journal.pone.0072299  PMCID:PMC3753302  PMID:23991085  
  7. Horani A, Ferkol TW, Shoseyov D, Wasserman MG, Oren YS, Kerem B, Amirav I, Cohen-Cymberknoh M, Dutcher SK, Brody SL, Elpeleg O, Kerem E. LRRC6 mutation causes primary ciliary dyskinesia with dynein arm defects. PLoS One. 2013;8(3):e59436. doi:10.1371/journal.pone.0059436  PMCID:PMC3602302  PMID:23527195  
  8. Horani A, Dickinson JD, Brody SL. Applications of mouse airway epithelial cell culture for asthma research. Methods Mol Biol. 2013;1032:91-107. doi:10.1007/978-1-62703-496-8_7  PMID:23943446  
  9. Horani A, Druley TE, Zariwala MA, Patel AC, Levinson BT, Van Arendonk LG, Thornton KC, Giacalone JC, Albee AJ, Wilson KS, Turner EH, Nickerson DA, Shendure J, Bayly PV, Leigh MW, Knowles MR, Brody SL, Dutcher SK, Ferkol TW. Whole-exome capture and sequencing identifies HEATR2 mutation as a cause of primary ciliary dyskinesia. Am J Hum Genet. 2012;91(4):685-93. doi:10.1016/j.ajhg.2012.08.022  PMCID:PMC3484505  PMID:23040496  
  10. Horani A, Shoseyov D, Ginsburg I, Mruwat R, Doron S, Amer J, Safadi R. Triphala (PADMA) extract alleviates bronchial hyperreactivity in a mouse model through liver and spleen immune modulation and increased anti-oxidative effects. Ther Adv Respir Dis. 2012;6(4):199-210. doi:10.1177/1753465812452194  PMID:22763675  
  11. Jain R, Javidan-Nejad C, Alexander-Brett J, Horani A, Cabellon MC, Walter MJ, Brody SL. Sensory functions of motile cilia and implication for bronchiectasis. Front Biosci (Schol Ed). 2012;4:1088-98. PMCID:PMC3841983  PMID:22202111  
  12. Horani A, Shoseyov D, Doron S, Mruwat R, Amer J, Kerem E, Safadi R. Immune modulation of ovalbumin-induced lung injury in mice using β-glucosylceramide and a potential role of the liver. Immunobiology. 2011;216(5):548-57. doi:10.1016/j.imbio.2010.10.002  PMID:21074892  
  13. Ginsburg I, Koren E, Horani A, Mahamid M, Doron S, Muhanna N, Amer J, Safadi R. Amelioration of hepatic fibrosis via Padma Hepaten is associated with altered natural killer T lymphocytes. Clin Exp Immunol. 2009;157(1):155-64. doi:10.1111/j.1365-2249.2009.03936.x  PMCID:PMC2710603  PMID:19659781  
  14. Orlev A, Horani A, Rapson Y, Cohen MJ, Blumenthal EZ. Clinical characteristics of eyes demonstrating atypical patterns in scanning laser polarimetry. Eye (Lond). 2008;22(11):1378-83. doi:10.1038/sj.eye.6702897  PMID:17627289  
  15. Muhanna N, Doron S, Wald O, Horani A, Eid A, Pappo O, Friedman SL, Safadi R. Activation of hepatic stellate cells after phagocytosis of lymphocytes: A novel pathway of fibrogenesis. Hepatology. 2008;48(3):963-77. doi:10.1002/hep.22413  PMCID:PMC2880478  PMID:18726940  
  16. Higazi AA, El-Haj M, Melhem A, Horani A, Pappo O, Alvarez CE, Muhanna N, Friedman SL, Safadi R. Immunomodulatory effects of plasminogen activators on hepatic fibrogenesis. Clin Exp Immunol. 2008;152(1):163-73. doi:10.1111/j.1365-2249.2008.03606.x  PMCID:PMC2384070  PMID:18279442  
  17. Muhanna N, Horani A, Doron S, Safadi R. Lymphocyte-hepatic stellate cell proximity suggests a direct interaction. Clin Exp Immunol. 2007;148(2):338-47. doi:10.1111/j.1365-2249.2007.03353.x  PMCID:PMC1868876  PMID:17437422  
  18. Horani A, Muhanna N, Pappo O, Melhem A, Alvarez CE, Doron S, Wehbi W, Dimitrios K, Friedman SL, Safadi R. Beneficial effect of glatiramer acetate (Copaxone) on immune modulation of experimental hepatic fibrosis. Am J Physiol Gastrointest Liver Physiol. 2007;292(2):G628-38. doi:10.1152/ajpgi.00137.2006  PMID:17038628  
  19. Horani A, Frenkel S, Blumenthal EZ. Test-retest variability in visual field testing using frequency doubling technology. Eur J Ophthalmol. 2007;17(2):203-7. PMID:17415693  
  20. Melhem A, Muhanna N, Bishara A, Alvarez CE, Ilan Y, Bishara T, Horani A, Nassar M, Friedman SL, Safadi R. Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC. J Hepatol. 2006;45(1):60-71. doi:10.1016/j.jhep.2005.12.025  PMID:16515819  
  21. Frenkel S, Katz S, Horani A, Kaiserman I, Asleh SA, Blumenthal EZ. Estimating intraocular pressure using a glass rod. Ann Ophthalmol (Skokie). 2006;38(3):195-9. PMID:17416953  
  22. Blumenthal EZ, Horani A, Sasikumar R, Garudadri C, Udaykumar A, Thomas R. Correlating structure with function in end-stage glaucoma. Ophthalmic Surg Lasers Imaging. 2006;37(3):218-23. PMID:16749258  
  23. Horani A, Frenkel S, Blumenthal EZ. The effect of pupil dilation on scanning laser polarimetry with variable corneal compensation. Ophthalmic Surg Lasers Imaging. 2006;37(3):212-6. PMID:16749257  
  24. Frenkel S, Slonim E, Horani A, Molcho M, Barzel I, Blumenthal EZ. Operator learning effect and interoperator reproducibility of the scanning laser polarimeter with variable corneal compensation. Ophthalmology. 2005;112(2):257-61. doi:10.1016/j.ophtha.2004.08.013  PMID:15691560  
  25. Horani A, Ulitsky J, Kalish Y, Safadi R. Hodgkin's disease in pregnancy. Isr Med Assoc J. 2004;6(8):502-3. PMID:15326837  
  26. Blumenthal EZ, Haddad A, Horani A, Anteby I. The reliability of frequency-doubling perimetry in young children. Ophthalmology. 2004;111(3):435-9. doi:10.1016/j.ophtha.2003.06.018  PMID:15019315  
  27. Horani A, Frenkel S, Yahalom C, Farber MD, Ticho U, Blumenthal EZ. The learning effect in visual field testing of healthy subjects using frequency doubling technology. J Glaucoma. 2002;11(6):511-6. PMID:12483097  
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