Mark E. Lowe, M.D., Ph.D.  lowe@wustl.edu

Chairman's OfficeGastroenterology, Hepatology and Nutrition

phone: (314) 454-6173

Education

  • BA, Washington University1973
  • PhD, University of Pennsylvania1977
  • MD, University of Miami1984

Training

  • Staff Fellow in Biochemistry, National Institutes of Health1977 - 1980
  • Staff Fellow in Pediatric Metabolism, National Institutes of Health1980 - 1981
  • Senior Staff Fellow in Pediatric Metabolism, National Institutes of Health1981 - 1982
  • Pediatric Intern in Pediatrics, St. Louis Children’s Hospital1984 - 1985
  • Pediatric Resident in Pediatrics, St. Louis Children’s Hospital1985 - 1986
  • Pediatric Fellow in Gastroenterology, St. Louis Children’s Hospital1986 - 1989

Licensure and Board Certification

  • National Board of Medical Examiners 1985
  • MO Missouri State Medical License 1986
  • Pediatrics - ABP 1989
  • Pediatric Gastroenterology - ABP 1995
  • DEA BL0736768 2002
  • MO Missouri State BNDD 2002
  • PA Pennsylvania State Medical License 2003
  • The American Board of Pediatrics (ABP) Maintenance of Certification (MOC) 2014

Honors

  • Omicron Delta Kappa1973
  • AGA-Industry Scholar Award (declined)1990
  • FIRST Award, National Institutes of Health1990
  • American Heart Association Established Investigator1992
  • Society for Pediatric Research1993
  • Mead Johnson Nutritionals Award from the American Institute of Nutrition (Renamed the American Society for Nutritional Sciences)1996
  • American Pediatric Society2004
  • Courage for the Cure Award, National Pancreas Foundation2010
  • Opponent, Thesis Defense, University of Lund, Sweden2010
  • Best Doctors in America2012 - Pres
  • Carol Ann Craumer Endowed Chair for Pediatric Reseach2015 - 2017
  • Fellow of the American Gastroenterological Association2017

Recent Publications view all (90)


Publication Co-Authors

  1. Early-Onset Acute Recurrent and Chronic Pancreatitis Is Associated with PRSS1 or CTRC Gene Mutations. J Pediatr. 2017;186:95-100. PMCID:PMC5506853  PMID:28502372 
  2. Therapeutic Endoscopic Retrograde Cholangiopancreatography in Pediatric Patients With Acute Recurrent and Chronic Pancreatitis: Data From the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) Study. Pancreas. 2017;46(6):764-769. PMCID:PMC5502745  PMID:28609364 
  3. Risk Factors for Asparaginase-associated Pancreatitis: A Systematic Review. J Clin Gastroenterol. 2017. PMID:28375864 
  4. Causal Evaluation of Acute Recurrent and Chronic Pancreatitis in Children: Consensus From the INSPPIRE Group. J Pediatr Gastroenterol Nutr. 2017;64(1):95-103. PMCID:PMC5191966  PMID:27782962 
  5. Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Pancreas. 2016;45(10):1365-1375. PMCID:PMC5117429  PMID:27748719 
  6. A Carboxyl Ester Lipase (CEL) Mutant Causes Chronic Pancreatitis by Forming Intracellular Aggregates That Activate Apoptosis. J Biol Chem. 2016;291(44):23224-23236. PMCID:PMC5087739  PMID:27650499 
  7. Risk Factors Associated With Pediatric Acute Recurrent and Chronic Pancreatitis: Lessons From INSPPIRE. JAMA Pediatr. 2016;170(6):562-9. PMCID:PMC5317277  PMID:27064572 
  8. A prognostic tool to predict severe acute pancreatitis in pediatrics. Pancreatology. 2016;16(3):358-64. PMID:27051062 
  9. Direct Costs of Acute Recurrent and Chronic Pancreatitis in Children in the INSPPIRE Registry. J Pediatr Gastroenterol Nutr. 2016;62(3):443-9. PMCID:PMC4767646  PMID:26704866 
  10. Valproic Acid Limits Pancreatic Recovery after Pancreatitis by Inhibiting Histone Deacetylases and Preventing Acinar Redifferentiation Programs. Am J Pathol. 2015;185(12):3304-15. PMCID:PMC4729237  PMID:26476347 
  11. The β5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 (PNLIPRP2). J Biol Chem. 2015;290(48):28847-56. PMCID:PMC4661400  PMID:26494624 
  12. A novel mutation in PNLIP causes pancreatic triglyceride lipase deficiency through protein misfolding. Biochim Biophys Acta. 2015;1852(7):1372-9. PMCID:PMC4645278  PMID:25862608 
  13. Forkhead Box O6 (FoxO6) Depletion Attenuates Hepatic Gluconeogenesis and Protects against Fat-induced Glucose Disorder in Mice. J Biol Chem. 2015;290(25):15581-94. PMCID:PMC4505471  PMID:25944898 
  14. A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition. J Pediatr Surg Case Rep. 2015;3(5):223-226. PMCID:PMC4864014  PMID:27182490 
  15. Pediatric chronic pancreatitis is associated with genetic risk factors and substantial disease burden. J Pediatr. 2015;166(4):890-896.e1. PMCID:PMC4380827  PMID:25556020 
  16. Pediatric chronic pancreatitis is associated with genetic risk factors and substantial disease burden J Pediatr. 2015;166(4):890-6 e1. PMID:25556020 
  17. Design and implementation of INSPPIRE. J Pediatr Gastroenterol Nutr. 2014;59(3):360-4. PMCID:PMC4141003  PMID:24824361 
  18. The histopathology of PRSS1 hereditary pancreatitis. Am J Surg Pathol. 2014;38(3):346-53. PMCID:PMC4321743  PMID:24525505 
  19. Visual diagnosis: 12-year-old girl with constipation and rectal bleeding. Pediatr Rev. 2014;35(2):e11-4. PMID:24488834 
  20. Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest. Pancreatology. 2014;14(1):27-35. PMCID:PMC4058640  PMID:24555976 
  21. Porcine pancreatic lipase related protein 2 has high triglyceride lipase activity in the absence of colipase. Biochim Biophys Acta. 2013;1831(9):1435-41. PMCID:PMC3742628  PMID:23770034 
  22. Pancreatic lipase-related protein 2 digests fats in human milk and formula in concert with gastric lipase and carboxyl ester lipase. Pediatr Res. 2013;74(2):127-32. PMCID:PMC3737390  PMID:23732775 
  23. Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis: recommendations from PancreasFest 2012. Pancreatology. 2013;13(4):336-42. PMCID:PMC3830751  PMID:23890130 
  24. Identification of amino acids in human colipase that mediate adsorption to lipid emulsions and mixed micelles. Biochim Biophys Acta. 2013;1831(6):1052-9. PMCID:PMC3642234  PMID:23470256 
  25. The Arg92Cys colipase polymorphism impairs function and secretion by increasing protein misfolding. J Lipid Res. 2013;54(2):514-21. PMCID:PMC3837459  PMID:23204298 
  26. Definitions of pediatric pancreatitis and survey of present clinical practices. J Pediatr Gastroenterol Nutr. 2012;55(3):261-5. PMCID:PMC3626452  PMID:22357117 
  27. IP3 receptor type 2 deficiency is associated with a secretory defect in the pancreatic acinar cell and an accumulation of zymogen granules. PLoS One. 2012;7(11):e48465. PMCID:PMC3504040  PMID:23185258 
  28. Pancreatic lipase-related protein-2 (PLRP2) can contribute to dietary fat digestion in human newborns. J Biol Chem. 2011;286(30):26353-63. PMCID:PMC3143598  PMID:21652702 
  29. Kinetic properties of mouse pancreatic lipase-related protein-2 suggest the mouse may not model human fat digestion. J Lipid Res. 2011;52(5):982-90. PMCID:PMC3073462  PMID:21382969 
  30. What have we learned about acute pancreatitis in children? J Pediatr Gastroenterol Nutr. 2011;52(3):262-70. PMCID:PMC3626416  PMID:21336157 
  31. Pharmacology and safety of glycerol phenylbutyrate in healthy adults and adults with cirrhosis. Hepatology. 2010;51(6):2077-85. PMCID:PMC3733097  PMID:20512995 
  32. Increasing incidence of acute pancreatitis at an American pediatric tertiary care center: is greater awareness among physicians responsible? Pancreas. 2010;39(1):5-8. PMID:19752770 
  33. Enterostatin deficiency increases serum cholesterol but does not influence growth and food intake in mice. Am J Physiol Endocrinol Metab. 2009;297(4):E856-65. PMCID:PMC2763786  PMID:19622781 
  34. Pancreatic lipase-related protein 2 (PLRP2) induction by IL-4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity. J Leukoc Biol. 2009;86(3):701-12. PMCID:PMC2735286  PMID:19451396 
  35. Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs). Cell Biochem Funct. 2009;27(5):296-308. PMCID:PMC2837949  PMID:19548271 
  36. Trp-107 and trp-253 account for the increased steady state fluorescence that accompanies the conformational change in human pancreatic triglyceride lipase induced by tetrahydrolipstatin and bile salt. J Biol Chem. 2009;284(21):14157-64. PMCID:PMC2682864  PMID:19346257 
  37. Hydrolysis of tumor cell lipids after CTL-mediated death. Int Immunol. 2009;21(5):543-53. PMCID:PMC2733839  PMID:19325035 
  38. Carboxyl ester lipase from either mother's milk or the pancreas is required for efficient dietary triglyceride digestion in suckling mice. J Nutr. 2008;138(5):927-30. PMCID:PMC3687517  PMID:18424603 
  39. Etiology and outcome of acute pancreatitis in infants and toddlers. J Pediatr. 2008;152(1):106-10, 110.e1. PMID:18154910 
  40. Bile salt-stimulated lipase and pancreatic lipase-related protein 2 are the dominating lipases in neonatal fat digestion in mice and rats. Pediatr Res. 2007;62(5):537-41. PMCID:PMC3488855  PMID:17805199 
  41. Hereditary pancreatitis amlodipine trial: a pilot study of a calcium-channel blocker in hereditary pancreatitis. Pancreas. 2007;35(4):308-12. PMID:18090235 
  42. A polymorphism in the gene encoding procolipase produces a colipase, Arg92Cys, with decreased function against long-chain triglycerides. J Lipid Res. 2007;48(11):2478-84. PMCID:PMC3684974  PMID:17715423 
  43. Acute pancreatitis in association with Campylobacter jejuni-associated diarrhea in a 15-year-old with CFTR mutations: is there a link? JOP. 2006;7(5):482-5. PMID:16998246 
  44. Val-407 and Ile-408 in the beta5'-loop of pancreatic lipase mediate lipase-colipase interactions in the presence of bile salt micelles. J Biol Chem. 2006;281(12):7793-800. PMCID:PMC3695395  PMID:16431912 
  45. Real-time measurement of solute partitioning to lipid monolayers. Anal Biochem. 2005;346(1):139-49. PMID:16188221 
  46. Expression of a novel cadherin in the mouse and human intestine. Pediatr Res. 2004;55(6):927-34. PMID:15028844 
  47. Pancreatic lipase-related protein 2 is the major colipase-dependent pancreatic lipase in suckling mice. J Nutr. 2004;134(1):132-4. PMCID:PMC2528064  PMID:14704305 
  48. Pancreatic triacylglycerol lipase in a hibernating mammal. II. Cold-adapted function and differential expression. Physiol Genomics. 2003;16(1):131-40. PMID:14583599 
  49. Inhibition of lipases by epsilon-polylysine. J Lipid Res. 2003;44(12):2278-86. PMID:12951365 
  50. Effect of long-term high-fat feeding on the expression of pancreatic lipases and adipose tissue uncoupling proteins in mice. Pancreas. 2003;26(2):e36-42. PMCID:PMC3488857  PMID:12604926 
  51. Protection from pancreatitis by the zymogen granule membrane protein integral membrane-associated protein-1. J Biol Chem. 2002;277(52):50725-33. PMCID:PMC3701954  PMID:12401800 
  52. The beta 5' loop of the pancreatic lipase C2-like domain plays a critical role in the lipase-lipid interactions. Biochemistry. 2002;41(46):13725-35. PMID:12427035 
  53. Persistent hyperlipasemia caused by macrolipase in an adolescent. J Pediatr. 2002;141(1):129-31. PMID:12091864 
  54. Decreased postnatal survival and altered body weight regulation in procolipase-deficient mice. J Biol Chem. 2002;277(9):7170-7. PMCID:PMC2528063  PMID:11751900 
  55. Expression of a chimeric retroviral-lipase mRNA confers enhanced lipolysis in a hibernating mammal. Am J Physiol Regul Integr Comp Physiol. 2001;281(4):R1186-92. PMID:11557627 
  56. Colipase residues Glu64 and Arg65 are essential for normal lipase-mediated fat digestion in the presence of bile salt micelles. J Biol Chem. 2001;276(16):12505-12. PMID:11278590 
  57. Discoordinate expression of pancreatic lipase and two related proteins in the human fetal pancreas. Pediatr Res. 2000;47(2):184-8. PMID:10674344 
  58. The open lid mediates pancreatic lipase function. J Lipid Res. 2000;41(1):48-57. PMID:10627501 
  59. Structure and activity of rat pancreatic lipase-related protein 2. J Biol Chem. 1998;273(48):32121-8. PMID:9822688 
  60. Decreased neonatal dietary fat absorption and T cell cytotoxicity in pancreatic lipase-related protein 2-deficient mice. J Biol Chem. 1998;273(47):31215-21. PMCID:PMC3690502  PMID:9813028 
  61. Rat gastric procolipase: sequence, expression, and secretion during high-fat feeding. Gastroenterology. 1998;115(5):1179-85. PMID:9797373 
  62. The hydrophobic surface of colipase influences lipase activity at an oil-water interface. J Lipid Res. 1998;39(9):1759-67. PMID:9741688 
  63. Purification and characterization of human procolipase expressed in yeast cells. Protein Expr Purif. 1998;13(1):30-5. PMID:9631511 
  64. Human pancreatic triglyceride lipase expressed in yeast cells: purification and characterization. Protein Expr Purif. 1998;13(1):36-40. PMID:9631512 
  65. Colipase stabilizes the lid domain of pancreatic triglyceride lipase. J Biol Chem. 1997;272(1):9-12. PMID:8995215 
  66. Pancreatic lipase-related protein 2 but not classical pancreatic lipase hydrolyzes galactolipids. Biochim Biophys Acta. 1996;1302:236-40. 
  67. Mutation of the catalytic site Asp177 to Glu177 in human pancreatic lipase produces an active lipase with increased sensitivity to proteases. Biochim Biophys Acta. 1996;1302(2):177-83. PMID:8695668 
  68. Dexamethasone-regulated expression of pancreatic lipase and two related proteins in AR42J cells. Am J Physiol. 1996;270(5 Pt 1):G746-51. PMID:8967484 
  69. Rat GP-3 is a pancreatic lipase with kinetic properties that differ from colipase-dependent pancreatic lipase. J Lipid Res. 1995;36(11):2374-82. PMID:8656075 
  70. C-terminal domain of human pancreatic lipase is required for stability and maximal activity but not colipase reactivation. J Lipid Res. 1995;36(5):1029-36. PMID:7658150 
  71. Human pancreatic procolipase expressed in insect cells: purification and characterization. Protein Expr Purif. 1994;5(6):583-6. PMID:7858428 
  72. A surface loop covering the active site of human pancreatic lipase influences interfacial activation and lipid binding. J Biol Chem. 1994;269(41):25470-4. PMID:7929247 
  73. Rat pancreatic lipase and two related proteins: enzymatic properties and mRNA expression during development. Am J Physiol. 1994;266(5 Pt 1):G914-21. PMCID:PMC3523700  PMID:8203536 
  74. The human pancreatic lipase-encoding gene: structure and conservation of an Alu sequence in the lipase gene family. Gene. 1993;131(2):281-5. PMID:8406023 
  75. The catalytic site residues and interfacial binding of human pancreatic lipase. J Biol Chem. 1992;267(24):17069-73. PMID:1512245 
  76. The human colipase gene: isolation, chromosomal location, and tissue-specific expression. Biochemistry. 1992;31(31):7120-5. PMID:1643046 
  77. Structure of the human pancreatic cholesterol esterase gene. Biochemistry. 1992;31(26):6077-81. PMID:1627550 
  78. Site-specific mutations in the COOH-terminus of placental alkaline phosphatase: a single amino acid change converts a phosphatidylinositol-glycan-anchored protein to a secreted protein. J Cell Biol. 1992;116(3):799-807. PMCID:PMC2289307  PMID:1730777 
  79. Isolation and characterization of the gene from a human genome encoding 17 beta-estradiol dehydrogenase: a comparison of Jar and BeWo choriocarcinoma cell lines. Am J Obstet Gynecol. 1990;163(6 Pt 1):1976-81. PMID:2256510 
  80. Expression of a Nagao-type, phosphatidylinositol-glycan anchored alkaline phosphatase in human choriocarcinomas. Cancer Res. 1990;50(13):3956-62. PMID:2162249 
  81. Molecular cloning and expression of a cDNA encoding the membrane-associated rat intestinal alkaline phosphatase. Biochim Biophys Acta. 1990;1037(2):170-7. PMID:2155025 
  82. Cloning and characterization of the human colipase cDNA. Biochemistry. 1990;29(3):823-8. PMID:2337598 
  83. Cloning and characterization of human pancreatic lipase cDNA. J Biol Chem. 1989;264(33):20042-8. PMID:2479644 
  84. A method of purification of partially methylated alditol acetates in the methylation analysis of glycoproteins and glycopeptides. Anal Biochem. 1984;136(1):187-91. PMID:6711806 
  85. The structure of the complex type oligosaccharide from rabbit hepatic binding protein. A re-examination. J Biol Chem. 1983;258(3):1885-7. PMID:6822540 
  86. Radiation inactivation of the glycoprotein, invertase. J Biol Chem. 1982;257(21):12478-80. PMID:6752136 
  87. Immunological approaches to the study of membrane receptors. A monoclonal antibody that inhibits the binding of asialoglycoproteins to the rat liver receptor. J Biol Chem. 1982;257(21):12685-90. PMID:6290477 
  88. Solubilization and assay of an hepatic receptor for the haptoglobin--hemoglobin complex. Arch Biochem Biophys. 1982;216(2):704-10. PMID:6287941 
  89. Fibronectin alters the phenotypic properties of cultured chick embryo chondroblasts. Cell. 1979;17(3):491-501. PMID:476827 
  90. Effects of phorbol-12-myristate-13-acetate on the phenotypic program of cultured chondroblasts and fibroblasts. Cancer Res. 1978;38(8):2350-6. PMID:667832 
Last updated: 08/10/2017
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