David Rosen, M.D., Ph.D.  rosen_d@kids.wustl.edu

Instructor in Pediatrics, Infectious Diseases
Infectious DiseasesPathobiology

phone: (314) 454-6050

Clinical Interests

Dr. Rosen evaluates children with a variety of infectious diseases at St. Louis Children's Hospital. He has a particular interest in the treatment of resistant Gram-negative bacterial infections.

In the research lab, Dr. Rosen studies basic pathogenic mechanisms of Klebsiella pneumoniae. This organism often carries sets of genes that render it resistant to most, if not all, antibiotics available. Klebsiella, and other carbapenem-resistant Enterobacteriaceae (CRE), have recently been assigned a threat level of urgent by the CDC. Utilizing mouse models of pneumonia and urinary tract infection, Dr. Rosen dissects mechanisms by which Klebsiella pneumoniae infects the host. Specific interests includes differential regulation of virulence determinants, including type 1 pili and capsule, and adaptive immune responses to Klebsiella in the lung. The ultimate goal is to develop further understanding of Klebsiella pneumoniae pathogenesis, which may reveal alternative therapies to combat these resistant organisms.

Education

  • B.S., University of Michigan2002
  • M.D., Washington University School of Medicine2010
  • Ph.D., Washington University School of Medicine2010

Training

  • Pediatric Internship and Residency, St. Louis Children's Hospital2010 - 2012
  • Pediatric Infectious Disease Fellowship, Washington University School of Medicine, St. Louis Children's Hospital2012 - 2016

Licensure and Board Certification

  • MO, Physician and Surgeon License2012
  • General Pediatrics, American Board of Pediatrics2013

Honors

  • Farmington Rotary Foundation Daniel Waldman Memorial Scholarship1998
  • State of Michigan House of Representatives Certificate of Recognition1998
  • University of Michigan Regents-Alumni Scholarship1998
  • William Beaumont Hospital Scholarship1998 - 2001
  • University of Michigan James B. Angell Scholar1999 - 2002
  • National Stark Scholarship for Chemistry and Biochemistry2001
  • American Institute of Chemistry Merit Award for Biochemistry2002
  • Washington University Medical School Teaching Assistant of the Year2007
  • Washington University Teaching Citation2008
  • Alexander Berg Prize for Microbiology Research2010
  • St. Louis Children’s Hospital Chief Resident Award2012
  • Pediatric Infectious Diseases Society Fellowship Award2013 - 2015
  • St. Louis Children’s Hospital Outstanding Fellow Teaching Award2015 - 2016
  • Pediatric Infectious Diseases Society Fellow Video Award2015

Recent Publications view all (5)


Publication Co-Authors

  1. Rosen DA, Hilliard JK, Tiemann KM, Todd EM, Morley SC, Hunstad DA. Klebsiella pneumoniae FimK Promotes Virulence in Murine Pneumonia. J Infect Dis. 2016;213(4):649-58. PMCID:PMC4721909  PMID:26347570  
  2. Rosen DA, Hung CS, Kline KA, Hultgren SJ. Streptozocin-induced diabetic mouse model of urinary tract infection. Infect Immun. 2008;76(9):4290-8. PMCID:PMC2519435  PMID:18644886  
  3. Rosen DA, Pinkner JS, Walker JN, Elam JS, Jones JM, Hultgren SJ. Molecular variations in Klebsiella pneumoniae and Escherichia coli FimH affect function and pathogenesis in the urinary tract. Infect Immun. 2008;76(7):3346-56. PMCID:PMC2446687  PMID:18474655  
  4. Rosen DA, Pinkner JS, Jones JM, Walker JN, Clegg S, Hultgren SJ. Utilization of an intracellular bacterial community pathway in Klebsiella pneumoniae urinary tract infection and the effects of FimK on type 1 pilus expression. Infect Immun. 2008;76(7):3337-45. PMCID:PMC2446714  PMID:18411285  
  5. Rosen DA, Hooton TM, Stamm WE, Humphrey PA, Hultgren SJ. Detection of intracellular bacterial communities in human urinary tract infection. PLoS Med. 2007;4(12):e329. PMCID:PMC2140087  PMID:18092884  
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