Lori R. Holtz, M.D., M.S.P.H.  holtz_l@kids.wustl.edu

Gastroenterology, Hepatology and NutritionPathobiology

phone: (314) 454-6173


  • B.S., Tulane University1999
  • M.D., The Ohio State University College of Medicine2003
  • MSPH, St. Louis University School of Public Health2014


  • Residency, Vanderbilt Children's Hospital2003 - 2006
  • Fellowship, Washington University2006 - 2009

Licensure and Board Certification

  • American Board of Pediatrics2006
  • MO, 2008
  • American Board of Pediatrics, Sub-board of Pediatric Gastroenterology2009


  • National Science Scholar1995
  • Tulane University Partial Academic Scholarship1995 - 1999
  • Funding from the National Science Foundation research experience for undergraduates1998
  • Cum Laude, Tulane University1999
  • NASPGHAN travel grant2008
  • Children's Discovery Institute Faculty Scholar2013 - Pres
  • St. Louis Best Doctors2015 - 2016
  • Washington University Institute for Public Health Scholar2016 - Pres

Recent Publications view all (22)

Publication Co-Authors

  1. Melamed R, Storch GA, Holtz LR, Klein EJ, Herrin B, Tarr PI, Denno DM. Case-Control Assessment of the Roles of Noroviruses, Human Bocaviruses 2, 3, and 4, and Novel Polyomaviruses and Astroviruses in Acute Childhood Diarrhea. J Pediatric Infect Dis Soc. 2017. PMID:28186546  
  2. Janowski AB, Krishnamurthy SR, Lim ES, Zhao G, Brenchley JM, Barouch DH, Thakwalakwa C, Manary MJ, Holtz LR, Wang D. Statoviruses, A novel taxon of RNA viruses present in the gastrointestinal tracts of diverse mammals. Virology. 2017;504:36-44. PMID:28152382  
  3. Xaverius P, Alman C, Holtz L, Yarber L. Risk Factors Associated with Very Low Birth Weight in a Large Urban Area, Stratified by Adequacy of Prenatal Care. Matern Child Health J. 2016;20(3):623-9. doi:10.1007/s10995-015-1861-4  PMID:26537389  
  4. Ng, T.F.F., Zhang, W., Sachsenroder, J., Kondov, N.O., Charlys da Costa, A., Vega, E., Holtz, L.R., Wu, G., Wang, D., Stine, O.C., Antonio, M., Mulvaney, U.S., Muench, M.O., Deng, X., Ambert-Balay, K., Pothier, P., Vinje, J., Delwart, E. A diverse group of small circular ssDNA viral genomes in human and non-human primate stools. Virus Evolution . 2015. doi: http://dx.doi.org/10.1093/ve/vev017  
  5. Lim ES, Zhou Y, Zhao G, Bauer IK, Droit L, Ndao IM, Warner BB, Tarr PI, Wang D, Holtz LR. Early life dynamics of the human gut virome and bacterial microbiome in infants. Nat Med. 2015. doi:10.1038/nm.3950  PMID:26366711  
  6. Meyer CT, Bauer IK, Antonio M, Adeyemi M, Saha D, Oundo JO, Ochieng JB, Omore R, Stine OC, Wang D, Holtz LR. Prevalence of classic, MLB-clade and VA-clade Astroviruses in Kenya and The Gambia. Virol J. 2015;12:78. doi:10.1186/s12985-015-0299-z  PMCID:PMC4465002  PMID:25975198  
  7. Holtz LR, Cao S, Zhao G, Bauer IK, Denno DM, Klein EJ, Antonio M, Stine OC, Snelling TL, Kirkwood CD, Wang D. Geographic variation in the eukaryotic virome of human diarrhea. Virology. 2014;468-470:556-64. doi:10.1016/j.virol.2014.09.012  PMCID:PMC4254309  PMID:25262473  
  8. Holtz LR, Bauer IK, Jiang H, Belshe R, Freiden P, Schultz-Cherry SL, Wang D. Seroepidemiology of astrovirus MLB1. Clin Vaccine Immunol. 2014;21(6):908-11. doi:10.1128/CVI.00100-14  PMID:24789796  
  9. Lim ES, Cao S, Holtz LR, Antonio M, Stine OC, Wang D. Discovery of rosavirus 2, a novel variant of a rodent-associated picornavirus, in children from The Gambia. Virology. 2014;454-455:25-33. doi:10.1016/j.virol.2014.01.018  PMID:24725928  
  10. Jiang H, Holtz LR, Bauer I, Franz CJ, Zhao G, Bodhidatta L, Shrestha SK, Kang G, Wang D. Comparison of novel MLB-clade, VA-clade and classic human astroviruses highlights constrained evolution of the classic human astrovirus nonstructural genes. Virology. 2013;436(1):8-14. doi:10.1016/j.virol.2012.09.040  PMCID:PMC3545029  PMID:23084422  
  11. Siebrasse EA, Bauer I, Holtz LR, Le BM, Lassa-Claxton S, Canter C, Hmiel P, Shenoy S, Sweet S, Turmelle Y, Shepherd R, Wang D. Human polyomaviruses in children undergoing transplantation, United States, 2008-2010. Emerg Infect Dis. 2012;18(10):1676-9. doi:10.3201/eid1810.120359  PMCID:PMC3471627  PMID:23017293  
  12. Ahmed SF, Sebeny PJ, Klena JD, Pimentel G, Mansour A, Naguib AM, Bruton J, Young SY, Holtz LR, Wang D. Novel astroviruses in children, Egypt. Emerg Infect Dis. 2011;17(12):2391-3. doi:10.3201/eid1712.110909  PMCID:PMC3311207  PMID:22172277  
  13. Holtz LR, Wylie KM, Sodergren E, Jiang Y, Franz CJ, Weinstock GM, Storch GA, Wang D. Astrovirus MLB2 viremia in febrile child. Emerg Infect Dis. 2011;17(11):2050-2. doi:10.3201/eid1711.110496  PMCID:PMC3310569  PMID:22099095  
  14. Holtz LR, Bauer IK, Rajendran P, Kang G, Wang D. Astrovirus MLB1 is not associated with diarrhea in a cohort of Indian children. PLoS One. 2011;6(12):e28647. doi:10.1371/journal.pone.0028647  PMCID:PMC3235140  PMID:22174853  
  15. Greninger AL, Holtz L, Kang G, Ganem D, Wang D, DeRisi JL. Serological evidence of human klassevirus infection. Clin Vaccine Immunol. 2010;17(10):1584-8. doi:10.1128/CVI.00152-10  PMCID:PMC2952992  PMID:20739504  
  16. Loh J, Zhao G, Presti RM, Holtz LR, Finkbeiner SR, Droit L, Villasana Z, Todd C, Pipas JM, Calgua B, Girones R, Wang D, Virgin HW. Detection of novel sequences related to african Swine Fever virus in human serum and sewage. J Virol. 2009;83(24):13019-25. doi:10.1128/JVI.00638-09  PMCID:PMC2786824  PMID:19812170  
  17. Finkbeiner SR, Holtz LR, Jiang Y, Rajendran P, Franz CJ, Zhao G, Kang G, Wang D. Human stool contains a previously unrecognized diversity of novel astroviruses. Virol J. 2009;6:161. doi:10.1186/1743-422X-6-161  PMCID:PMC2765957  PMID:19814825  
  18. Holtz LR, Finkbeiner SR, Zhao G, Kirkwood CD, Girones R, Pipas JM, Wang D. Klassevirus 1, a previously undescribed member of the family Picornaviridae, is globally widespread. Virol J. 2009;6:86. doi:10.1186/1743-422X-6-86  PMCID:PMC2706813  PMID:19552824  
  19. Holtz LR, Neill MA, Tarr PI. Acute bloody diarrhea: a medical emergency for patients of all ages. Gastroenterology. 2009;136(6):1887-98. doi:10.1053/j.gastro.2009.02.059  PMID:19457417  
  20. Finkbeiner SR, Le BM, Holtz LR, Storch GA, Wang D. Detection of newly described astrovirus MLB1 in stool samples from children. Emerg Infect Dis. 2009;15(3):441-4. doi:10.3201/eid1503.081213  PMCID:PMC2666294  PMID:19239759  
  21. Holtz LR, Finkbeiner SR, Kirkwood CD, Wang D. Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea. Virol J. 2008;5:159. doi:10.1186/1743-422X-5-159  PMCID:PMC2615758  PMID:19102772  
  22. Voss TC, Goldman LR, Seek SL, Miller TL, Mayo KE, Somogyvari-Vigh A, Arimura A, Hurley DL. GH mRNA levels are elevated by forskolin but not GH releasing hormone in GHRH receptor-expressing MtT/S somatotroph cell line. Mol Cell Endocrinol. 2001;172(1-2):125-34. PMID:11165046  
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