Scott Saunders, M.D., Ph.D.

Associate Professor of Pediatrics, Newborn Medicine
Developmental BiologyNewborn Medicine

phone: (314) 454-6148


  • B.S., University of Minnesota 1983
  • M.D., Stanford University School of Medicine1990
  • Ph.D., Stanford University School of Medicine1990


  • Intern in Medicine, Children's Hospital, Boston, MA1990 - 1991
  • Resident in Medicine, Children's Hospital, Boston, MA1991 - 1993
  • Postdoc Fellow, Brain & Cognitive Sciences , Massachusetts Institute of Technology, MA1993 - 1995
  • Clinical Fellow in Newborn Medicine, Joint Program in Neonatology, Harvard Medical School 1993 - 1996

Licensure and Board Certification

  • Federal Aviation Administration, Private Pilot, Airplane Single Engine Land1980
  • National Board of Medical Examiners, Diplomate1991
  • MA, Physician/Board of Registration in Medicine1993
  • American Board of Pediatrics, General Pediatrics Certification1993
  • MO, Physician & Surgeon/Board of Registration for the Healing Arts1997
  • American Board of Pediatrics, Neonatal-Perinatal Medicine Certification2008
  • IL, Physician & Surgeon/Dept. of Financial and Professional Regulation2015
  • Advanced Trauma Life Support2015
  • C-NPT (Neonatal Pediatric Transport)2016
  • Neonatal Resuscitation Program2016
  • Pediatric Advanced Life Support2016
  • Advanced Cardiac Life Support2016
  • Basic Life Support2016
  • CEVO 3: Ambulance2017


  • Alumni Scholarship, College of Biological Sciences, University of Minnesota1982
  • Phi Beta Kappa1983
  • Summa cum Laude, Biochemistry1983
  • Medical Student Research Award, Society for Pediatric Research1989
  • Howard Hughes Medical Institute Postdoctoral Research Fellowship for Physicians1994
  • Reynolds Rich Smith Fellowship in Development and Function of the Central Nervous System1994
  • Wyeth Pediatrics Neonatology Research Grant1994
  • Basil O'Connor Starter Scholar Research Award, March of Dimes Birth Defects Foundation1997
  • Scholar, NIH-designated Child Health Research Center, Washington University School of Medicine1997
  • Spoehrer Scholar Award, Department of Pediatrics, Washington University School of Medicine1999
  • Society for Pediatric Research, Member2001

Recent Publications view all (21)

Publication Co-Authors

  1. Ellies DL, Economou A, Viviano B, Rey JP, Paine-Saunders S, Krumlauf R, Saunders S. Wise regulates bone deposition through genetic interactions with Lrp5. PLoS One. 2014;9(5):e96257. doi:10.1371/journal.pone.0096257  PMCID:PMC4006890  PMID:24789067  
  2. Stankiewicz P, Kulkarni S, Dharmadhikari AV, Sampath S, Bhatt SS, Shaikh TH, Xia Z, Pursley AN, Cooper ML, Shinawi M, Paciorkowski AR, Grange DK, Noetzel MJ, Saunders S, Simons P, Summar M, Lee B, Scaglia F, Fellmann F, Martinet D, Beckmann JS, Asamoah A, Platky K, Sparks S, Martin AS, Madan-Khetarpal S, Hoover J, Medne L, Bonnemann CG, Moeschler JB, Vallee SE, Parikh S, Irwin P, Dalzell VP, Smith WE, Banks VC, Flannery DB, Lovell CM, Bellus GA, Golden-Grant K, Gorski JL, Kussmann JL, McGregor TL, Hamid R, Pfotenhauer J, Ballif BC, Shaw CA, Kang SH, Bacino CA, Patel A, Rosenfeld JA, Cheung SW, Shaffer LG. Recurrent deletions and reciprocal duplications of 10q11.21q11.23 including CHAT and SLC18A3 are likely mediated by complex low-copy repeats. Hum Mutat. 2012;33(1):165-79. doi:10.1002/humu.21614  PMCID:PMC3655525  PMID:21948486  
  3. Thach BT, Kenney-Hunt JP, Simon TC, Stratman JL, Thach SB, Harris KA, Saunders S, Cheverud JM. Sex-specific quantitative trait loci linked to autoresuscitation failure in SWR/J mice. Heredity (Edinb). 2009;103(6):469-75. doi:10.1038/hdy.2009.89  PMCID:PMC2783180  PMID:19654605  
  4. Ng A, Wong M, Viviano B, Erlich JM, Alba G, Pflederer C, Jay PY, Saunders S. Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development. Dev Biol. 2009;335(1):208-15. doi:10.1016/j.ydbio.2009.08.029  PMCID:PMC2763964  PMID:19733558  
  5. Ellies DL, Viviano B, McCarthy J, Rey JP, Itasaki N, Saunders S, Krumlauf R. Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity. J Bone Miner Res. 2006;21(11):1738-49. doi:10.1359/jbmr.060810  PMID:17002572  
  6. Vachharajani A, Bethin K, Mouillet JF, Sadovsky Y, Saunders S. The rare occurrence of absent adrenals in a term infant: a case report and review of the literature. Am J Perinatol. 2006;23(2):111-4. doi:10.1055/s-2006-931911  PMID:16506117  
  7. Vachharajani A, Saunders S. Allelic variation in the serotonin transporter (5HTT) gene contributes to idiopathic pulmonary hypertension in children. Biochem Biophys Res Commun. 2005;334(2):376-9. doi:10.1016/j.bbrc.2005.06.107  PMID:16009349  
  8. Viviano BL, Silverstein L, Pflederer C, Paine-Saunders S, Mills K, Saunders S. Altered hematopoiesis in glypican-3-deficient mice results in decreased osteoclast differentiation and a delay in endochondral ossification. Dev Biol. 2005;282(1):152-62. doi:10.1016/j.ydbio.2005.03.003  PMID:15936336  
  9. Viviano BL, Paine-Saunders S, Gasiunas N, Gallagher J, Saunders S. Domain-specific modification of heparan sulfate by Qsulf1 modulates the binding of the bone morphogenetic protein antagonist Noggin. J Biol Chem. 2004;279(7):5604-11. doi:10.1074/jbc.M310691200  PMID:14645250  
  10. Paine-Saunders S, Viviano BL, Economides AN, Saunders S. Heparan sulfate proteoglycans retain Noggin at the cell surface: a potential mechanism for shaping bone morphogenetic protein gradients. J Biol Chem. 2002;277(3):2089-96. doi:10.1074/jbc.M109151200  PMID:11706034  
  11. Paine-Saunders S, Viviano BL, Zupicich J, Skarnes WC, Saunders S. glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development. Dev Biol. 2000;225(1):179-87. doi:10.1006/dbio.2000.9831  PMID:10964473  
  12. Paine-Saunders S, Viviano BL, Saunders S. GPC6, a novel member of the glypican gene family, encodes a product structurally related to GPC4 and is colocalized with GPC5 on human chromosome 13. Genomics. 1999;57(3):455-8. doi:10.1006/geno.1999.5793  PMID:10329016  
  13. Saunders S, Paine-Saunders S, Lander AD. Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain. Dev Biol. 1997;190(1):78-93. doi:10.1006/dbio.1997.8690  PMID:9331333  
  14. Kato M, Saunders S, Nguyen H, Bernfield M. Loss of cell surface syndecan-1 causes epithelia to transform into anchorage-independent mesenchyme-like cells. Mol Biol Cell. 1995;6(5):559-76. PMCID:PMC301215  PMID:7545031  
  15. Saunders S, Jalkanen M, O'Farrell S, Bernfield M. Molecular cloning of syndecan, an integral membrane proteoglycan. J Cell Biol. 1989;108(4):1547-56. PMCID:PMC2115498  PMID:2494194  
  16. Saunders S, Bernfield M. Cell surface proteoglycan binds mouse mammary epithelial cells to fibronectin and behaves as a receptor for interstitial matrix. J Cell Biol. 1988;106(2):423-30. PMCID:PMC2114970  PMID:2963012  
  17. Jalkanen M, Rapraeger A, Saunders S, Bernfield M. Cell surface proteoglycan of mouse mammary epithelial cells is shed by cleavage of its matrix-binding ectodomain from its membrane-associated domain. J Cell Biol. 1987;105(6 Pt 2):3087-96. PMCID:PMC2114732  PMID:3320062  
  18. Saunders S, Hedlund BE. Electrostatic modification of protein surfaces: effect on hemoglobin ligation and solubility. Biochemistry. 1984;23(7):1457-61. PMID:6426506  
  19. Ramakrishnan K, Oppenhuizen ME, Saunders S, Fisher J. Stereoselectivity of chloroperoxidase-dependent halogenation. Biochemistry. 1983;22(13):3271-7. PMID:6882748  
  20. Ellies DL, Economou A, Viviano B, Paine-Saunders S, Chan L, Saunders S, Krumlauf R. The function of Wise and genetic interactions with Lrp5 in the regulation of bone density. In preparation.  
  21. Funches L, Wang M, Viviano B, Saunders S. The role of glypican-3 in modulating IHH-, BMP- and FGF-dependent skeletal growth and development. In preparation.  
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