Over the last 35 years, Dr. White's clinical and research interests have focused on diabetes mellitus. This includes clinical and translational research related to diabetes mellitus, both type 1 and type 2, in children and adolescents. Much of his research has been through active participation in multicenter NIH-supported clinical trials including DCCT/EDIC, DPP/DPPOS, TODAY, DirecNet, TRIGR and TrialNet. In addition to serving as local PI for these trials, he has national leadership roles in DirecNet and TODAY. Throughout his career, he has had an ongoing interest in: 1) methods of intensive therapy in type 1 diabetes; 2) the risks associated with hypoglycemia in diabetic subjects, including effects on brain structure and function; 3) studies of diabetes prevention; and 4) psychosocial interventions in teenagers with diabetes. Dr. White has also had a longstanding interest in the diagnosis and management of hypoglycemia in infants and children, including hyperinsulinism and glycogen storage disease.