Megan A. Cooper, M.D., Ph.D.  cooper_m@kids.wustl.edu

Assistant Professor of Pediatrics and Pathology and Immunology
RheumatologyPathobiology

phone: (314) 454-6124

Clinical Interests

Dr. Cooper received her MD and PhD training at The Ohio State University in Columbus, Ohio. Her PhD work focused on understanding the biology of a subset of human immune cells known as “natural killer” or NK cells. After graduating from medical school she moved to St. Louis and completed her residency and fellowship training at St. Louis Children’s Hospital and Washington University. Dr. Cooper has a clinical interest in primary disorders of the immune system and sees patients in the rheumatology and immunology clinics.

Education

  • B.A., The College of Wooster1995
  • Ph.D., The Ohio State University2002
  • M.D., Cum Laude, AOA, MD/PhD Fellow, The Ohio State University2004

Training

  • Resident in Pediatrics, St. Louis Children's Hospital, Washington University2004 - 2006
  • Fellowship in Pediatric Rheumatology, Washington University2006 - 2010

Licensure and Board Certification

  • American Board of Pediatrics, General Pediatrics2007
  • MO, Missouri State Medical License2010
  • American Board of Pediatrics - Pediatric Rheumatology2011

Honors

  • National Merit Finalist1991
  • Lewis LaShell Chemistry Scholarship, The College of Wooster1994
  • National Science Foundation Research Undergraduate Fellowship1994
  • Phi Beta Kappa National Honor Society1995
  • Bertha Bouroncle Internal Medicine Research Fellowship1998 - 1999
  • 1st Place, Oral Presentation, Landare Day Medical Student Research Forum1999
  • Howard Hughes Medical Institute (HHMI) Medical Student Research Fellow1999 - 2000
  • American Society of Hematology (ASH) Medical Student Award2001
  • Carroll L. Birch Award, for the best original research paper by a student member of the American Medical Women's Association (AMWA)2001
  • Roche Molecular Biochemicals Distinguished Graduate Seminar Award2001
  • Phi Kappa Phi National Graduate Honor Society2002
  • Alpha Omega Alpha (AOA) Honor Medical Society2003
  • Grant Morrow III, MD, Award for Excellence in Pediatrics, The Ohio State University2004
  • Internal Medicine Research Award, The Ohio State University2004
  • Medical Scientist Award, The Ohio State University College of Medicine2004
  • Watman Achievement Award, Alpha Omega Alpha Society, The Ohio State University2004
  • David Gilstrap Award, Washington University School of Medicine Department of Pediatrics2007
  • Pediatric NIH Loan Repayment Grant (LRP), NIH/NIAID2007 - 2013
  • Scholar of the NIH Child Health Research Center, Washington University Department of Pediatrics2009 - 2013
  • Best Original Basic Science Abstract, Washington University Department of Pediatrics Research Retreat2010
  • Children's Discovery Institute and St. Louis Children's Hospital Faculty Recruit Award2010 - 2015
  • Children’s Discovery Institute of Washington University and St. Louis Children’s Hospital Interdisciplinary Research Award2012 - 2015
  • The American Association of Immunologists (AAI) Early Career Faculty Travel Grant2014
  • “Lecturer of the Month”, St. Louis Children’s Hospital Residency Program, March 20162016

Recent Publications view all (26)


Publication Co-Authors

  1. Lovric S, Goncalves S, Gee HY, Oskouian B, Srinivas H, Choi WI, Shril S, Ashraf S, Tan W, Rao J, Airik M, Schapiro D, Braun DA, Sadowski CE, Widmeier E, Jobst-Schwan T, Schmidt JM, Girik V, Capitani G, Suh JH, Lachaussée N, Arrondel C, Patat J, Gribouval O, Furlano M, Boyer O, Schmitt A, Vuiblet V, Hashmi S, Wilcken R, Bernier FP, Innes AM, Parboosingh JS, Lamont RE, Midgley JP, Wright N, Majewski J, Zenker M, Schaefer F, Kuss N, Greil J, Giese T, Schwarz K, Catheline V, Schanze D, Franke I, Sznajer Y, Truant AS, Adams B, Désir J, Biemann R, Pei Y, Ars E, Lloberas N, Madrid A, Dharnidharka VR, Connolly AM, Willing MC, Cooper MA, Lifton RP, Simons M, Riezman H, Antignac C, Saba JD, Hildebrandt F. Mutations in sphingosine-1-phosphase lyase cause nephrosis with ichthyosis and adrenal insufficiency. J Clin Invest. 2017. PMID:28165339  
  2. Romee R, Rosario M, Berrien-Elliott MM, Wagner JA, Jewell BA, Schappe T, Leong JW, Abdel-Latif S, Schneider SE, Willey S, Neal CC, Yu L, Oh ST, Lee YS, Mulder A, Claas F, Cooper MA, Fehniger TA. Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia. Sci Transl Med. 2016;8(357):357ra123. PMID:27655849  
  3. Fotis L, Baszis KW, French AR, Cooper MA, White AJ. Mesenteric vasculitis in children with systemic lupus erythematosus. Clin Rheumatol. 2016;35(3):785-93. doi:10.1007/s10067-015-2892-3  PMID:25687984  
  4. Keppel MP, Saucier N, Mah AY, Vogel TP, Cooper MA. Activation-specific metabolic requirements for NK Cell IFN-γ production. J Immunol. 2015;194(4):1954-1962. doi:10.4049/jimmunol.1402099  PMID:25595780  
  5. Milner JD, Vogel TP, Forbes L, Ma CA, Stray-Pedersen A, Niemela JE, Lyons JJ, Engelhardt KR, Zhang Y, Topcagic N, Roberson ED, Matthews H, Verbsky JW, Dasu T, Vargas-Hernandez A, Varghese N, McClain KL, Karam LB, Nahmod K, Makedonas G, Mace EM, Sorte HS, Perminow G, Rao VK, O'Connell MP, Price S, Su HC, Butrick M, McElwee J, Hughes JD, Willet J, Swan D, Xu Y, Santibanez-Koref M, Slowik V, Dinwiddie DL, Ciaccio CE, Saunders CJ, Septer S, Kingsmore SF, White AJ, Cant AJ, Hambleton S, Cooper MA. Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations. Blood. 2015;125(4):591-599.. doi:10.1182/blood-2014-09-602763  PMID:25359994  
  6. Tarbox JA, Keppel MP, Topcagic N, Mackin C, Ben Abdallah M, Baszis KW, White AJ, French AR, Cooper MA. Elevated double negative T cells in pediatric autoimmunity. J Clin Immunol. 2014;34(5):594-9. doi:10.1007/s10875-014-0038-z  PMCID:PMC4047151  PMID:24760111  
  7. Leong JW, Chase JM, Romee R, Schneider SE, Sullivan RP, Cooper MA, Fehniger TA. Preactivation with IL-12, IL-15, and IL-18 induces CD25 and a functional high-affinity IL-2 receptor on human cytokine-induced memory-like natural killer cells. Biol Blood Marrow Transplant. 2014;20(4):463-73. doi:10.1016/j.bbmt.2014.01.006  PMCID:PMC3959288  PMID:24434782  
  8. Deady LE, Todd EM, Davis CG, Zhou JY, Topcagic N, Edelson BT, Ferkol TW, Cooper MA, Muenzer JT, Morley SC. L-plastin is essential for alveolar macrophage production and control of pulmonary pneumococcal infection. Infect Immun. 2014. doi:10.1128/IAI.01199-13  PMID:24595139  
  9. Lim E, Tao Y, White AJ, French AR, Cooper MA. Hypogammaglobulinemia in pediatric systemic lupus erythematosus. Lupus. 2013;22(13):1382-7. doi:10.1177/0961203313507990  PMCID:PMC3840537  PMID:24106215  
  10. Keppel MP, Yang L, Cooper MA. Murine NK cell intrinsic cytokine-induced memory-like responses are maintained following homeostatic proliferation. J Immunol. 2013;190(9):4754-62. doi:10.4049/jimmunol.1201742  PMCID:PMC3633638  PMID:23530145  
  11. Romee R, Schneider SE, Leong JW, Chase JM, Keppel CR, Sullivan RP, Cooper MA, Fehniger TA. Cytokine activation induces human memory-like NK cells. Blood. 2012;120(24):4751-60. doi:10.1182/blood-2012-04-419283  PMCID:PMC3520618  PMID:22983442  
  12. Kitcharoensakkul M, Ree N, Bloomberg GR, Dehner LP, Heidingsfelder JA, White AJ, Cooper MA. Vancomycin-induced DRESS with evidence of T-cell activation in a 22-month-old patient. Ann Allergy Asthma Immunol. 2012;109(4):280-1. doi:10.1016/j.anai.2012.07.016  PMID:23010236  
  13. Cooper MA, Elliott JM, Keyel PA, Yang L, Carrero JA, Yokoyama WM. Cytokine-induced memory-like natural killer cells. Proc Natl Acad Sci U S A. 2009;106(6):1915-9. doi:10.1073/pnas.0813192106  PMCID:PMC2644138  PMID:19181844  
  14. Cooper MA, Willingham DL, Brown DE, French AR, Shih FF, White AJ. Rituximab for the treatment of juvenile dermatomyositis: a report of four pediatric patients. Arthritis Rheum. 2007;56(9):3107-11. doi:10.1002/art.22856  PMID:17763414  
  15. Fehniger TA, Cooper MA, Nuovo GJ, Cella M, Facchetti F, Colonna M, Caligiuri MA. CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity. Blood. 2003;101(8):3052-7. doi:10.1182/blood-2002-09-2876  PMID:12480696  
  16. Cooper MA, Bush JE, Fehniger TA, VanDeusen JB, Waite RE, Liu Y, Aguila HL, Caligiuri MA. In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells. Blood. 2002;100(10):3633-8. doi:10.1182/blood-2001-12-0293  PMID:12393617  
  17. Comella K, Nakamura M, Melnik K, Chosy J, Zborowski M, Cooper MA, Fehniger TA, Caligiuri MA, Chalmers JJ. Effects of antibody concentration on the separation of human natural killer cells in a commercial immunomagnetic separation system. Cytometry. 2001;45(4):285-93. PMID:11746098  
  18. Cooper MA, Fehniger TA, Caligiuri MA. The biology of human natural killer-cell subsets. Trends Immunol. 2001;22(11):633-40. PMID:11698225  
  19. Cooper MA, Fehniger TA, Turner SC, Chen KS, Ghaheri BA, Ghayur T, Carson WE, Caligiuri MA. Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset. Blood. 2001;97(10):3146-51. PMID:11342442  
  20. Cooper MA, Fehniger TA, Ponnappan A, Mehta V, Wewers MD, Caligiuri MA. Interleukin-1beta costimulates interferon-gamma production by human natural killer cells. Eur J Immunol. 2001;31(3):792-801. PMID:11241284  
  21. Fehniger TA, Suzuki K, Ponnappan A, VanDeusen JB, Cooper MA, Florea SM, Freud AG, Robinson ML, Durbin J, Caligiuri MA. Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells. J Exp Med. 2001;193(2):219-31. PMCID:PMC2193336  PMID:11208862  
  22. Carson WE, Dierksheide JE, Jabbour S, Anghelina M, Bouchard P, Ku G, Yu H, Baumann H, Shah MH, Cooper MA, Durbin J, Caligiuri MA. Coadministration of interleukin-18 and interleukin-12 induces a fatal inflammatory response in mice: critical role of natural killer cell interferon-gamma production and STAT-mediated signal transduction. Blood. 2000;96(4):1465-73. PMID:10942393  
  23. Fehniger TA, Bluman EM, Porter MM, Mrózek E, Cooper MA, VanDeusen JB, Frankel SR, Stock W, Caligiuri MA. Potential mechanisms of human natural killer cell expansion in vivo during low-dose IL-2 therapy. J Clin Invest. 2000;106(1):117-24. doi:10.1172/JCI6218  PMCID:PMC314354  PMID:10880055  
  24. Fehniger TA, Yu H, Cooper MA, Suzuki K, Shah MH, Caligiuri MA. Cutting edge: IL-15 costimulates the generalized Shwartzman reaction and innate immune IFN-gamma production in vivo. J Immunol. 2000;164(4):1643-7. PMID:10657604  
  25. Fehniger TA, Shah MH, Turner MJ, VanDeusen JB, Whitman SP, Cooper MA, Suzuki K, Wechser M, Goodsaid F, Caligiuri MA. Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: implications for the innate immune response. J Immunol. 1999;162(8):4511-20. PMID:10201989  
  26. Schanze KS, Lucia LA, Cooper M, Walter KA, Ji HF, Sabina O. Intramolecular energy transfer to trans-stilbene J Phys Chem A. 1998;102:5577-5584. 
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