Department of Pediatrics

Clinical Interests

Non-alcoholic fatty liver disease, Obesity

Education

• BS, Summa Cum Laude Distinction, University of Michigan, 2001
• MD, Washington University School of Medicine, 2008
• PhD, Olin Fellowship, Washington University School of Medicine, 2008

Training

• Residency, St. Louis Children's Hospital, 2008 - 2010
• Fellowship - Accelerated Research Pathway, Washington University School of Medicine, 2010 - 2014

Licensure and Board Certification

• 2008 - PresBasic Life Support
• 2008 - 2010Neonatal Resuscitation Program
• 2008 - 2010Pediatric Advanced Life Support
• 2013 - PresAmerican Board of Pediatrics
• 2015 - PresMO, Physician & Surgeon License
• 2015 - PresAmerican Board of Pediatrics (ABP), Pediatric Gastroenterology, Hepatology & Nutrition

Honors and Awards

• National Merit Scholar, 1997
• Regents-Alumni Scholar, University of Michigan, Ann Arbor, 1997
• UPAAM Outstanding Youth of Michigan Scholar, 1997
• Academic Merit Scholar, College of Literature, Science & Arts, University of Michigan, Ann Arbor, 1997 - 2001
• Ford Endowed Merit Scholar, 1997 - 2001
• James B. Angell Scholar, University of Michigan, Ann Arbor, 1997 - 2001
• Class Honors Award, University of Michigan, Ann Arbor, 1998 - 2001
• Sophomore Honors Award, University of Michigan, Ann Arbor, 1999
• Telluride Association Scholar, 1999 - 2001
• Barry M. Goldwater Scholar, 2000 - 2001
• Delta Phi Alpha National German Honor Society, 2001 - Pres
• National Council on Undergraduate Research Award, 2001
• Highest Honors Thesis Distinction, University of Michigan, Ann Arbor, 2001 - 2001
• Summa Cum Laude, University of Michigan, Ann Arbor, 2001 - 2001
• Triple Crown Award - St. Louis Children's Hospital, 2011
• Digestive Diseases Research Center P&F Award, 2013 - 2015
• Faculty Scholar - Children's Discovery Institute, 2014 - Pres
• Scholar - Child Health Research Center of Washington University School of Medicine, 2014 - Pres
• Early Investigator Award - the Endocrine Society, 2015 - Pres
• St. Louis Children's Hospital Recognition Award, 2015
• United States Department of Defense Discovery Award, 2017 - Pres
• Inductee, Society for Pediatric Research, 2018 - Pres
• Triple Crown Award - St. Louis Children's Hospital, 2018 - 2018
• Co-Inventor (Paul Hruz, MD, PhD), LEAP Inventor Challenge - Washington University School of Medicine Skandalaris Center: "Novel Treatment of Fatty Liver Disease", 2018 - Pres
• Doris Duke Charitable Foundation Clinical Scientist Development Award, 2019 - Pres
• Early Career Reviewer - NIH / CSR, 2020 - 2020
• AGA Institute Research Awards Panel, 2020 - Pres
• AASLD Pilot Research Award, 2020 - 2021

Recent Publications view all (34)

Publication Co-Authors

Misty Good, M.D., M.S.

Phillip I. Tarr, M.D.

Kristine Wylie, Ph.D.

Michael Thompson

Todd N. Wylie

Paul W. Hruz, M.D., Ph.D.

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Brian DeBosch, M.D., Ph.D.

1. McCommis KS, Kovacs A, Weinheimer CJ, Shew TM, Koves TR, Ilkayeva OR, Kamm DR, Pyles KD, King MT, Veech RL, DeBosch BJ, Muoio DM, Gross RW, Finck BN. Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice. Nat Metab. 2020;2(11):1232-1247. PMID:33106690 
2. Robert N. Helsley, Francois Moreau, Manoj K. Gupta, Aurelia Radulescu, Brian DeBosch, Samir Softic. Tissue-Specific Fructose Metabolism in Obesity and Diabetes Curr Diab Rep. 2020;20:64. doi:10.1007/s11892-020-01342-8  
3. Kading J, Finck BN, DeBosch BJ. Targeting hepatocyte carbohydrate transport to mimic fasting and calorie restriction. FEBS. 2020. doi:doi: 10.1111/febs.15482  PMID:32654397 
4. Zhang Y and DeBosch BJ. Microbial and metabolic impacts of trehalose and trehalose analogues Gut Microbes. 2020;24:1-8. doi:doi: 10.1080/19490976.2020.1750273  PMID:32329657 
5. Zhang Y, Shaikh N, Ferey JL, Wankhade UD, Chintapalli SV, Higgins CB, Crowley JR, Heitmeier MR, Stothard AI, Mihi B, Good M, Higashiyama T, Swarts BM, Hruz PW, Shankar K, Tarr PI and DeBosch BJ. Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice Gastroenterology. 2020;158(5):1402-1416.e2. doi:doi: 10.1053/j.gastro.2019.11.295  PMCID:PMC7103499   
6. Zhang Y, Shaikh N, Ferey JL, Wankhade UD, Chintapalli SV, Higgins CB, Crowley JR, Heitmeier MR, Stothard AI, Mihi B, Good M, Higashiyama T, Swarts BM, Hruz PW, Shankar K, Tarr PI, DeBosch BJ. Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice. Gastroenterology. 2020;158(5):1402-1416.e2. PMCID:PMC7103499  PMID:31838076 
7. Zhang Y and DeBosch BJ. Using trehalose to prevent and treat metabolic function: effectiveness and mechanisms Curr Opin Clin Nutr Metab Care. 2019;22(4):303-310. doi:10.1097/MCO.0000000000000568  PMID:31033580 
8. Xie Y, Matsumoto H, Kennedy S, Newberry EP, Moritz W, DeBosch BJ, Moley KH, Rubin DC, Warner BW, Kau AL, Tarr PI, Wylie TN, Wylie KM, Davidson NO. Impaired Chylomicron Assembly Modifies Hepatic Metabolism Through Bile Acid-Dependent and Transmissible Microbial Adaptations. Hepatology. 2019;70(4):1168-1184. doi:10.1002/hep.30669  PMCID:PMC6783349  PMID:31004524 
9. Zhang Y, Higgins CB, Fortune HM, Chen P, Stothard AI, Swarts BM, DeBosch BJ. Hepatocyte Arginase 2 is sufficient to convey the therapeutic metabolic effects of fasting Nature Communications. 2019;10:1587. doi:0.1038/s41467-019-09642-8  PMCID:PMC6453920  PMID:30962478 
10. Danielson ND, Collins J, Stothard AI, Dong Q, Kalera K, Woodruff P, DeBosch BJ, Britton RA, Swarts BM . Degradation-Resistant Trehalose Analogues Block Utilization of Trehalose by Hypervirulent Clostridioides difficile Chem Comm. 2019;55(34):5009-5012. doi:10.1039/C9CC01300H  PMCID:PMC6499371  PMID:30968891 
11. Berna AZ, DeBosch B, Stoll J, John ARO. Breath Collection from Children for Disease Biomarker Discovery J. Vis. Exp.. 2019; 144:e59217. doi:10.3791/59217  PMCID:PMC6596991  PMID:30829338 
12. Ferey J, Boudoures A, Reid M, Drury A, Scheaffer S, Modi Z, Kovacs A, Pietka T, DeBosch BJ, Thompson MD, Diwan A, and Moley KH. Maternal High-Fat, High-Sucrose Diet Induces Transgenerational Cardiac Mitochondrial Dysfunction Independent of Maternal Mitochondrial Inheritance AJP Heart Circ Physiol. 2019;316(5):H1202-H1210. doi:10.1152/ajpheart.00013.2019  PMCID: PMC6580388  PMID:30901280 
13. Bauckman KA, Matsuda R, Higgins CB, DeBosch BJ, Wang C, Mysorekar IU. Dietary restriction of iron availability attenuates UPEC pathogenesis in a mouse model of urinary tract infection. Am J Physiol Renal Physiol. 2019. doi:10.1152/ajprenal.00133.2018  PMCID:PMC6580250  PMID:30724105 
14. Higgins CB, Zhang Y, Mayer AL, Fujiwara H, Stothard AI, Graham MJ, Swarts BM, DeBosch BJ. Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPARγ. JCI Insight. 2018;3(16). PMCID:PMC6141168  PMID:30135298 
15. Mayer AL, Zhang Y, Feng EH, Higgins CB, Adenekan O, Pietka TA, Beatty WL, DeBosch BJ. Enhanced Hepatic PPARα Activity Links GLUT8 Deficiency to Augmented Peripheral Fasting Responses in Male Mice. Endocrinology. 2018;159(5):2110-2126. PMCID:PMC6366533  PMID:29596655 
16. Zhang Y, Higgins CB, Mayer AL, Mysorekar IU, Razani B, Graham MJ, Hruz PW, DeBosch BJ. Transcription Factor EB (TFEB)-dependent Induction of Thermogenesis by the Hepatocyte Solute Carrier 2A (SLC2A) inhibitor, Trehalose Autophagy. 2018;24(22):2959-1975. doi:10.1080/15548627.2018.1493044  PMCID:PMC6152536  PMID:29996716 
17. Mayer AL, Higgins CB, Heitmeier MR, Kraft TE, Qian X, Crowley JR, Hyrc KL, Beatty WL, Yarasheski KE, Hruz PW, DeBosch BJ. SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy. Sci Rep. 2016;6:38586. PMCID:PMC5138640  PMID:27922102 
18. DeBosch BJ, Heitmeier MR, Mayer AL, Higgins CB, Crowley JR, Kraft TE, Chi M, Newberry EP, Chen Z, Finck BN, Davidson NO, Yarasheski KE, Hruz PW, Moley KH. Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis. Sci Signal. 2016;9(416):ra21. PMCID:PMC4816640  PMID:26905426 
19. Omurtag K, Esakky P, Debosch BJ, Schoeller EL, Chi MM, Moley KH. Modeling the effect of cigarette smoke on hexose utilization in spermatocytes. Reprod Sci. 2015;22(1):94-101. doi:10.1177/1933719114533727  PMCID:PMC4527419  PMID:24803506 
20. DeBosch BJ, Kluth O, Fujiwara H, Schürmann A, Moley K. Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9. Nat Commun. 2014;5:4642. doi:10.1038/ncomms5642  PMCID:PMC4348061  PMID:25100214 
21. Debosch BJ, Chen Z, Saben JL, Finck BN, Moley KH. Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis. J Biol Chem. 2014;289(16):10989-98. doi:10.1074/jbc.M113.527002  PMCID:PMC4036240  PMID:24519932 
22. DeBosch BJ, Chen Z, Finck BN, Chi M, Moley KH. Glucose transporter-8 (GLUT8) mediates glucose intolerance and dyslipidemia in high-fructose diet-fed male mice. Mol Endocrinol. 2013;27(11):1887-96. doi:10.1210/me.2013-1137  PMCID:PMC3805847  PMID:24030250 
23. DeBosch BJ, Chi M, Moley KH. Glucose transporter 8 (GLUT8) regulates enterocyte fructose transport and global mammalian fructose utilization. Endocrinology. 2012;153(9):4181-91. doi:10.1210/en.2012-1541  PMCID:PMC3423610  PMID:22822162 
24. Etzion S, Etzion Y, DeBosch B, Crawford PA, Muslin AJ. Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity. J Mol Cell Cardiol. 2010;49(6):931-40. doi:10.1016/j.yjmcc.2010.08.011  PMCID:PMC2975863  PMID:20728450 
25. Avery J, Etzion S, DeBosch BJ, Jin X, Lupu TS, Beitinjaneh B, Grand J, Kovacs A, Sambandam N, Muslin AJ. TRB3 function in cardiac endoplasmic reticulum stress. Circ Res. 2010;106(9):1516-23. doi:10.1161/CIRCRESAHA.109.211920  PMCID:PMC2913227  PMID:20360254 
26. DeBosch BJ, Brown D, Tse G, Hua M, Kodner IJ. Fetus-saving Caesarian rejection by pregnant woman: a case study. Surgery. 2009;145(1):6-8. PMID:19093328 
27. DeBosch BJ, Muslin AJ. Insulin signaling pathways and cardiac growth. J Mol Cell Cardiol. 2008;44(5):855-64. doi:10.1016/j.yjmcc.2008.03.008  PMCID:PMC2442827  PMID:18423486 
28. Lau JM, Jin X, Ren J, Avery J, DeBosch BJ, Treskov I, Lupu TS, Kovacs A, Weinheimer C, Muslin AJ. The 14-3-3tau phosphoserine-binding protein is required for cardiomyocyte survival. Mol Cell Biol. 2007;27(4):1455-66. doi:10.1128/MCB.01369-06  PMCID:PMC1800730  PMID:17145769 
29. DeBosch B, Sambandam N, Weinheimer C, Courtois M, Muslin AJ. Akt2 regulates cardiac metabolism and cardiomyocyte survival. J Biol Chem. 2006;281(43):32841-51. doi:10.1074/jbc.M513087200  PMCID:PMC2724003  PMID:16950770 
30. DeBosch B, Treskov I, Lupu TS, Weinheimer C, Kovacs A, Courtois M, Muslin AJ. Akt1 is required for physiological cardiac growth. Circulation. 2006;113(17):2097-104. doi:10.1161/CIRCULATIONAHA.105.595231  PMID:16636172 
31. Muslin AJ, DeBosch B. Role of Akt in cardiac growth and metabolism. Novartis Found Symp. 2006;274:118-26; discussion 126-31, 152-5, 272-6. PMID:17019809 
32. DeBosch BJ, Deo BK, Kumagai AK. Insulin-like growth factor-1 effects on bovine retinal endothelial cell glucose transport: role of MAP kinase. J Neurochem. 2002;81(4):728-34. PMID:12065632 
33. DeBosch BJ, Baur E, Deo BK, Hiraoka M, Kumagai AK. Effects of insulin-like growth factor-1 on retinal endothelial cell glucose transport and proliferation. J Neurochem. 2001;77(4):1157-67. PMID:11359881 
34. Michael P. Franczyk, Nathan Qi, Kelly L. Stromsdorfer, Chengcheng Li, Shintaro Yamaguchi1, Hiroshi Itoh, Mihoko Yoshino, Brian N. Finck, Brian J. DeBosch, Samuel Klein, Jun Yoshino. Importance of adipose tissue NAD+ biology in regulating metabolic flexibility Endocrinology.