Department of Pediatrics

Clinical Interests

Non-alcoholic fatty liver disease, Obesity

Education

• BS, Summa Cum Laude Distinction, University of Michigan, 2001
• MD, Washington University School of Medicine, 2008
• PhD, Olin Fellowship, Washington University School of Medicine, 2008

Training

• Residency, St. Louis Children's Hospital, 2008 - 2010
• Fellowship - Accelerated Research Pathway, Washington University School of Medicine, 2010 - 2014

Licensure and Board Certification

• Basic Life Support , 2008
• Neonatal Resuscitation Program , 2008
• Pediatric Advanced Life Support , 2008
• American Board of Pediatrics , 2013
• MO, Physician & Surgeon License , 2015
• Pediatric Gastroenterology, Hepatology & Nutrition , 2015

Honors

• National Merit Scholar, 1997
• Regents-Alumni Scholar, University of Michigan, Ann Arbor, 1997
• UPAAM Outstanding Youth of Michigan Scholar, 1997
• Academic Merit Scholar, College of Literature, Science & Arts, University of Michigan, Ann Arbor, 1997 - 2001
• Ford Endowed Merit Scholar, 1997 - 2001
• James B. Angell Scholar, University of Michigan, Ann Arbor, 1997 - 2001
• Class Honors Award, University of Michigan, Ann Arbor, 1998 - 2001
• Sophomore Honors Award, University of Michigan, Ann Arbor, 1999
• Telluride Association Scholar, 1999 - 2001
• Barry M. Goldwater Scholar, 2000 - 2001
• Delta Phi Alpha National German Honor Society, 2001 - Pres
• National Council on Undergraduate Research Award, 2001
• Highest Honors Thesis Distinction, University of Michigan, Ann Arbor, 2001 - 2001
• Summa Cum Laude, University of Michigan, Ann Arbor, 2001 - 2001
• Triple Crown Award - St. Louis Children's Hospital, 2011
• Digestive Diseases Research Center P&F Award, 2013 - 2015
• Faculty Scholar - Children's Discovery Institute, 2014 - Pres
• Nutrition & Obesity Research Center P&F Award, 2014 - Pres
• Scholar - Child Health Research Center of Washington University School of Medicine, 2014 - Pres
• Early Investigator Award - the Endocrine Society, 2015 - Pres
• American Gastroenterological Association / Gilead Sciences Research Scholars Award in Liver Disease, 2015 - 2018
• St. Louis Children's Hosptial Recognition Award, 2015
• Robert Wood Johnson Foundation Scholar - Amos Medical Faculty Development Program, 2016 - Pres
• United States Department of Defense Discovery Award, 2017 - Pres
• Inductee, Society for Pediatric Research, 2017 - Pres
• American Gastroenterological Association (AGA) / American Association for the study of Liver Diseases (AASLD) Conference Travel Award, 2018 - 2018
• St. Louis Children's Hospital Triple Crown Award for Safe, Effective and Exceptional Patient Care, 2018 - 2018
• Co-Inventor (Paul Hruz, MD, PhD), LEAP Inventor Challenge - Washington University School of Medicine Skandalaris Center: "Novel Treatment of Fatty Liver Disease", 2018 - Pres

Recent Publications view all (20)

Publication Co-Authors

Paul W. Hruz, M.D., Ph.D.

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Brian DeBosch, M.D., Ph.D.

1. Casssandra B Higgins, Yiming Zhang, Allyson L Mayer, Hidjei Fujiwara, Alicyn I Stothard, Mark J Graham, Benjamin M Swarts, Brian J DeBosch. Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPAR-gamma JCI Insight. 2018. doi:https://doi.org/10.1172/jci.insight.120794  
2. Mayer AL, Zhang Y, Feng EH, Higgins CB, Adenekan O, Pietka TA, Beatty WL, DeBosch BJ. Enhanced Hepatic PPARα Activity Links GLUT8 Deficiency to Augmented Peripheral Fasting Responses in Male Mice Endocrinology. 2018. 
3. Yiming Zhang, Cassandra B. Higgins, Allyson L. Mayer, Indira U. Mysorekar, Babak B. Razani, Mark J. Graham, Paul W. Hruz, Brian J. DeBosch . Transcription Factor EB (TFEB)-dependent Induction of Thermogenesis by the Hepatocyte Solute Carrier 2A (SLC2A) inhibitor, Trehalose Autophagy. 2018. 
4. Mayer AL, Higgins CB, Heitmeier MR, Kraft TE, Qian X, Crowley JR, Hyrc KL, Beatty WL, Yarasheski KE, Hruz PW, DeBosch BJ. SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy. Sci Rep. 2016;6:38586. PMID:27922102 
5. DeBosch BJ, Heitmeier MR, Mayer AL, Higgins CB, Crowley JR, Kraft TE, Chi M, Newberry EP, Chen Z, Finck BN, Davidson NO, Yarasheski KE, Hruz PW, Moley KH. Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis. Sci Signal. 2016;9(416):ra21. PMCID:PMC4816640  PMID:26905426 
6. Omurtag K, Esakky P, Debosch BJ, Schoeller EL, Chi MM, Moley KH. Modeling the effect of cigarette smoke on hexose utilization in spermatocytes. Reprod Sci. 2015;22(1):94-101. doi:10.1177/1933719114533727  PMID:24803506 
7. DeBosch BJ, Kluth O, Fujiwara H, Schürmann A, Moley K. Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9. Nat Commun. 2014;5:4642. doi:10.1038/ncomms5642  PMCID:PMC4348061  PMID:25100214 
8. Debosch BJ, Chen Z, Saben JL, Finck BN, Moley KH. Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis. J Biol Chem. 2014;289(16):10989-98. doi:10.1074/jbc.M113.527002  PMCID:PMC4036240  PMID:24519932 
9. DeBosch BJ, Chen Z, Finck BN, Chi M, Moley KH. Glucose transporter-8 (GLUT8) mediates glucose intolerance and dyslipidemia in high-fructose diet-fed male mice. Mol Endocrinol. 2013;27(11):1887-96. doi:10.1210/me.2013-1137  PMCID:PMC3805847  PMID:24030250 
10. DeBosch BJ, Chi M, Moley KH. Glucose transporter 8 (GLUT8) regulates enterocyte fructose transport and global mammalian fructose utilization. Endocrinology. 2012;153(9):4181-91. doi:10.1210/en.2012-1541  PMCID:PMC3423610  PMID:22822162 
11. Etzion S, Etzion Y, DeBosch B, Crawford PA, Muslin AJ. Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity. J Mol Cell Cardiol. 2010;49(6):931-40. doi:10.1016/j.yjmcc.2010.08.011  PMCID:PMC2975863  PMID:20728450 
12. Avery J, Etzion S, DeBosch BJ, Jin X, Lupu TS, Beitinjaneh B, Grand J, Kovacs A, Sambandam N, Muslin AJ. TRB3 function in cardiac endoplasmic reticulum stress. Circ Res. 2010;106(9):1516-23. doi:10.1161/CIRCRESAHA.109.211920  PMCID:PMC2913227  PMID:20360254 
13. DeBosch BJ, Brown D, Tse G, Hua M, Kodner IJ. Fetus-saving Caesarian rejection by pregnant woman: a case study. Surgery. 2009;145(1):6-8. PMID:19093328 
14. DeBosch BJ, Muslin AJ. Insulin signaling pathways and cardiac growth. J Mol Cell Cardiol. 2008;44(5):855-64. doi:10.1016/j.yjmcc.2008.03.008  PMCID:PMC2442827  PMID:18423486 
15. Lau JM, Jin X, Ren J, Avery J, DeBosch BJ, Treskov I, Lupu TS, Kovacs A, Weinheimer C, Muslin AJ. The 14-3-3tau phosphoserine-binding protein is required for cardiomyocyte survival. Mol Cell Biol. 2007;27(4):1455-66. doi:10.1128/MCB.01369-06  PMCID:PMC1800730  PMID:17145769 
16. DeBosch B, Sambandam N, Weinheimer C, Courtois M, Muslin AJ. Akt2 regulates cardiac metabolism and cardiomyocyte survival. J Biol Chem. 2006;281(43):32841-51. doi:10.1074/jbc.M513087200  PMCID:PMC2724003  PMID:16950770 
17. DeBosch B, Treskov I, Lupu TS, Weinheimer C, Kovacs A, Courtois M, Muslin AJ. Akt1 is required for physiological cardiac growth. Circulation. 2006;113(17):2097-104. doi:10.1161/CIRCULATIONAHA.105.595231  PMID:16636172 
18. Muslin AJ, DeBosch B. Role of Akt in cardiac growth and metabolism. Novartis Found Symp. 2006;274:118-26; discussion 126-31, 152-5, 272-6. PMID:17019809 
19. DeBosch BJ, Deo BK, Kumagai AK. Insulin-like growth factor-1 effects on bovine retinal endothelial cell glucose transport: role of MAP kinase. J Neurochem. 2002;81(4):728-34. PMID:12065632 
20. DeBosch BJ, Baur E, Deo BK, Hiraoka M, Kumagai AK. Effects of insulin-like growth factor-1 on retinal endothelial cell glucose transport and proliferation. J Neurochem. 2001;77(4):1157-67. PMID:11359881