Department of Pediatrics

Clinical Interests

Non-alcoholic fatty liver disease, Obesity

Education

• BS, Summa Cum Laude Distinction, University of Michigan, 2001
• MD, Washington University School of Medicine, 2008
• PhD, Olin Fellowship, Washington University School of Medicine, 2008

Training

• Residency, St. Louis Children's Hospital, 2008 - 2010
• Fellowship - Accelerated Research Pathway, Washington University School of Medicine, 2010 - 2014

Licensure and Board Certification

• 2008 - PresBasic Life Support
• 2008 - 2010Neonatal Resuscitation Program
• 2008 - 2010Pediatric Advanced Life Support
• 2013 - PresAmerican Board of Pediatrics
• 2015 - 2016MO, Physician & Surgeon License
• 2015 - PresPediatric Gastroenterology, Hepatology & Nutrition

Honors and Awards

• National Merit Scholar, 1997
• Regents-Alumni Scholar, University of Michigan, Ann Arbor, 1997
• UPAAM Outstanding Youth of Michigan Scholar, 1997
• Academic Merit Scholar, College of Literature, Science & Arts, University of Michigan, Ann Arbor, 1997 - 2001
• Ford Endowed Merit Scholar, 1997 - 2001
• James B. Angell Scholar, University of Michigan, Ann Arbor, 1997 - 2001
• Class Honors Award, University of Michigan, Ann Arbor, 1998 - 2001
• Sophomore Honors Award, University of Michigan, Ann Arbor, 1999
• Telluride Association Scholar, 1999 - 2001
• Barry M. Goldwater Scholar, 2000 - 2001
• Delta Phi Alpha National German Honor Society, 2001 - Pres
• National Council on Undergraduate Research Award, 2001
• Highest Honors Thesis Distinction, University of Michigan, Ann Arbor, 2001 - 2001
• Summa Cum Laude, University of Michigan, Ann Arbor, 2001 - 2001
• Triple Crown Award - St. Louis Children's Hospital, 2011
• Digestive Diseases Research Center P&F Award, 2013 - 2015
• Faculty Scholar - Children's Discovery Institute, 2014 - Pres
• Nutrition & Obesity Research Center P&F Award, 2014 - Pres
• Scholar - Child Health Research Center of Washington University School of Medicine, 2014 - Pres
• Early Investigator Award - the Endocrine Society, 2015 - Pres
• American Gastroenterological Association / Gilead Sciences Research Scholars Award in Liver Disease, 2015 - 2018
• St. Louis Children's Hosptial Recognition Award, 2015
• Robert Wood Johnson Foundation Scholar - Amos Medical Faculty Development Program, 2016 - Pres
• United States Department of Defense Discovery Award, 2017 - Pres
• Inductee, Society for Pediatric Research, 2018 - Pres
• St. Louis Children's Hospital Triple Crown Award for Safe, Effective and Exceptional Patient Care, 2018 - 2018
• Co-Inventor (Paul Hruz, MD, PhD), LEAP Inventor Challenge - Washington University School of Medicine Skandalaris Center: "Novel Treatment of Fatty Liver Disease", 2018 - Pres
• AGA/AASLD Young Investigator Conference Travel Award, 2018 - Pres
• AGA-Allergan Foundation Pilot Research Award in Non-Alcoholic Fatty Liver Disease, 2019 - Pres
• AGA-Allergan Pilot Research Award in Non-Alcoholic Fatty Liver Disease, 2019 - Pres
• Gilead Sciences Cardiovascular Co-Morbidities Research Award, 2019 - Pres
• Doris Duke Charitable Foundation Clinical Scientist Development Award, 2019 - Pres
• Junior Faculty Award - American Federation for Aging Research, 2019 - Pres
• Young Investigators Travel Award - The Obesity Society / NORC "Obesity Week" Scientific Sessions, 2019
• Early Career Reviewer - NIH / CSR, 2020 - 2020
• AASLD Pilot Research Award, 2020 - 2021

Recent Publications view all (31)

Publication Co-Authors

Misty Good, M.D., M.S.

Phillip I. Tarr, M.D.

Kristine Wylie, Ph.D.

Michael Thompson

Todd N. Wylie

Paul W. Hruz, M.D., Ph.D.

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Brian DeBosch, M.D., Ph.D.

1. Zhang Y, Shaikh N, Ferey JL, Wankhade UD, Chintapalli SV, Higgins CB, Crowley JR, Heitmeier MR, Stothard AI, Mihi B, Good MR, Higashiyama T, Swarts BM, Hruz PW, Shankar K, Tarr PI, DeBosch BJ.. Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice. Gastroenterology. 2019. doi:10.1053/j.gastro.2019.11.295.   PMID:31838076 
2. Yiming Zhang and Brian J DeBosch. Using trehalose to prevent and treat metabolic function: effectiveness and mechanisms Curr Opin Clin Nutr Metab Care. 2019. doi:10.1097/MCO.0000000000000568  PMID:31033580 
3. Xie Y, Matsumoto H, Kennedy S, Newberry EP, Moritz W, DeBosch BJ, Moley KH, Rubin DC, Warner BW, Kau AL, Tarr PI, Wylie TN, Wylie KM, Davidson NO. Impaired Chylomicron Assembly Modifies Hepatic Metabolism Through Bile Acid-Dependent and Transmissible Microbial Adaptations. Hepatology. 2019;70(4):1168-1184. doi:10.1002/hep.30669  PMCID:PMC6783349  PMID:31004524 
4. Yiming Zhang, Cassandra B Higgins, Hannah M Fortune, Phillip Chen, Alicyn I Stothard, Benjamin M Swarts, Brian J DeBosch. Hepatocyte Arginase 2 is sufficient to convey the therapeutic metabolic effects of fasting Nature Communications. 2019;10:1587. doi:0.1038/s41467-019-09642-8  PMID:30962478 
5. Danielson, N. C., James; Stothard, Alicyn; Dong, Qing Qing; Kalera, Karishma; Woodruff, Peter; DeBosch, Brian; Britton, Robert; Swarts, Benjamin . Degradation-Resistant Trehalose Analogues Block Utilization of Trehalose by Hypervirulent Clostridioides difficile Chem Comm. 2019. doi:10.1039/C9CC01300H  
6. Amalia Z. Berna, Brian DeBosch, Janis Stoll, Audrey R. Odom John. Breath Collection from Children for Disease Biomarker Discovery J. Vis. Exp.. 2019; 144:e59217. doi:10.3791/59217  PMID:30829338 
7. Jeremie Ferey, Anna Boudoures, Michaela Reid, Andrea Drury, Suzanne Scheaffer, Zeel Modi, Attila Kovacs, Terri Pietka, Brian DeBosch, Michael Thompson, Abhinav Diwan, and Kelle Moley. Maternal High-Fat, High-Sucrose Diet Induces Transgenerational Cardiac Mitochondrial Dysfunction Independent of Maternal Mitochondrial Inheritance AJP Heart Circ Physiol. 2019. doi:10.1152/ajpheart.00013.2019  PMID:30901280 
8. Bauckman KA, Matsuda R, Higgins CB, DeBosch BJ, Wang C, Mysorekar IU. Dietary restriction of iron availability attenuates UPEC pathogenesis in a mouse model of urinary tract infection. Am J Physiol Renal Physiol. 2019. doi:10.1152/ajprenal.00133.2018  PMID:30724105 
9. Higgins CB, Zhang Y, Mayer AL, Fujiwara H, Stothard AI, Graham MJ, Swarts BM, DeBosch BJ. Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPARγ. JCI Insight. 2018;3(16). PMCID:PMC6141168  PMID:30135298 
10. Mayer AL, Zhang Y, Feng EH, Higgins CB, Adenekan O, Pietka TA, Beatty WL, DeBosch BJ. Enhanced Hepatic PPARα Activity Links GLUT8 Deficiency to Augmented Peripheral Fasting Responses in Male Mice. Endocrinology. 2018;159(5):2110-2126. PMID:29596655 
11. Yiming Zhang, Cassandra B. Higgins, Allyson L. Mayer, Indira U. Mysorekar, Babak B. Razani, Mark J. Graham, Paul W. Hruz, Brian J. DeBosch . Transcription Factor EB (TFEB)-dependent Induction of Thermogenesis by the Hepatocyte Solute Carrier 2A (SLC2A) inhibitor, Trehalose Autophagy. 2018. 
12. Mayer AL, Higgins CB, Heitmeier MR, Kraft TE, Qian X, Crowley JR, Hyrc KL, Beatty WL, Yarasheski KE, Hruz PW, DeBosch BJ. SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy. Sci Rep. 2016;6:38586. PMID:27922102 
13. DeBosch BJ, Heitmeier MR, Mayer AL, Higgins CB, Crowley JR, Kraft TE, Chi M, Newberry EP, Chen Z, Finck BN, Davidson NO, Yarasheski KE, Hruz PW, Moley KH. Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis. Sci Signal. 2016;9(416):ra21. PMCID:PMC4816640  PMID:26905426 
14. Omurtag K, Esakky P, Debosch BJ, Schoeller EL, Chi MM, Moley KH. Modeling the effect of cigarette smoke on hexose utilization in spermatocytes. Reprod Sci. 2015;22(1):94-101. doi:10.1177/1933719114533727  PMID:24803506 
15. DeBosch BJ, Kluth O, Fujiwara H, Schürmann A, Moley K. Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9. Nat Commun. 2014;5:4642. doi:10.1038/ncomms5642  PMCID:PMC4348061  PMID:25100214 
16. Debosch BJ, Chen Z, Saben JL, Finck BN, Moley KH. Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis. J Biol Chem. 2014;289(16):10989-98. doi:10.1074/jbc.M113.527002  PMCID:PMC4036240  PMID:24519932 
17. DeBosch BJ, Chen Z, Finck BN, Chi M, Moley KH. Glucose transporter-8 (GLUT8) mediates glucose intolerance and dyslipidemia in high-fructose diet-fed male mice. Mol Endocrinol. 2013;27(11):1887-96. doi:10.1210/me.2013-1137  PMCID:PMC3805847  PMID:24030250 
18. DeBosch BJ, Chi M, Moley KH. Glucose transporter 8 (GLUT8) regulates enterocyte fructose transport and global mammalian fructose utilization. Endocrinology. 2012;153(9):4181-91. doi:10.1210/en.2012-1541  PMCID:PMC3423610  PMID:22822162 
19. Etzion S, Etzion Y, DeBosch B, Crawford PA, Muslin AJ. Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity. J Mol Cell Cardiol. 2010;49(6):931-40. doi:10.1016/j.yjmcc.2010.08.011  PMCID:PMC2975863  PMID:20728450 
20. Avery J, Etzion S, DeBosch BJ, Jin X, Lupu TS, Beitinjaneh B, Grand J, Kovacs A, Sambandam N, Muslin AJ. TRB3 function in cardiac endoplasmic reticulum stress. Circ Res. 2010;106(9):1516-23. doi:10.1161/CIRCRESAHA.109.211920  PMCID:PMC2913227  PMID:20360254 
21. DeBosch BJ, Brown D, Tse G, Hua M, Kodner IJ. Fetus-saving Caesarian rejection by pregnant woman: a case study. Surgery. 2009;145(1):6-8. PMID:19093328 
22. DeBosch BJ, Muslin AJ. Insulin signaling pathways and cardiac growth. J Mol Cell Cardiol. 2008;44(5):855-64. doi:10.1016/j.yjmcc.2008.03.008  PMCID:PMC2442827  PMID:18423486 
23. Lau JM, Jin X, Ren J, Avery J, DeBosch BJ, Treskov I, Lupu TS, Kovacs A, Weinheimer C, Muslin AJ. The 14-3-3tau phosphoserine-binding protein is required for cardiomyocyte survival. Mol Cell Biol. 2007;27(4):1455-66. doi:10.1128/MCB.01369-06  PMCID:PMC1800730  PMID:17145769 
24. DeBosch B, Sambandam N, Weinheimer C, Courtois M, Muslin AJ. Akt2 regulates cardiac metabolism and cardiomyocyte survival. J Biol Chem. 2006;281(43):32841-51. doi:10.1074/jbc.M513087200  PMCID:PMC2724003  PMID:16950770 
25. DeBosch B, Treskov I, Lupu TS, Weinheimer C, Kovacs A, Courtois M, Muslin AJ. Akt1 is required for physiological cardiac growth. Circulation. 2006;113(17):2097-104. doi:10.1161/CIRCULATIONAHA.105.595231  PMID:16636172 
26. Muslin AJ, DeBosch B. Role of Akt in cardiac growth and metabolism. Novartis Found Symp. 2006;274:118-26; discussion 126-31, 152-5, 272-6. PMID:17019809 
27. DeBosch BJ, Deo BK, Kumagai AK. Insulin-like growth factor-1 effects on bovine retinal endothelial cell glucose transport: role of MAP kinase. J Neurochem. 2002;81(4):728-34. PMID:12065632 
28. DeBosch BJ, Baur E, Deo BK, Hiraoka M, Kumagai AK. Effects of insulin-like growth factor-1 on retinal endothelial cell glucose transport and proliferation. J Neurochem. 2001;77(4):1157-67. PMID:11359881 
29. Yiming Zhang, Nurmohammad Shaikh, Jeremie L. Ferey, Umesh D. Wankhade, Sree V. Chintapalli, Cassandra B. Higgins, Jan R. Crowley, Monique R. Heitmeier, Alicyn I. Stothard, Belgacem Mihi, Misty R. Good, Takanobu Higashiyama, Benjamin M. Swarts, Paul W. Hruz, Kartik Shankar, Phillip I. Tarr and Brian J. DeBosch. Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice Gastroenterology. 
30. Allyson L Mayer, Hannah Fortune, Oyin Adenekan, Yiming Zhang, Cassandra B Higgins, Jeremie L Ferey, Carla J Weinheimer, Carrie M Gierasch, Patrick Y Jay, Attila Kovacs, Scot J Matkovich, Brian J DeBosch . The hepatic fasting response is cardioprotective. JCI Insight. 
31. Allyson L Mayer, Cassandra B Higgins, Jeremie L Ferey, Yiming Zhang, Carla J Weinheimer, Patrick Y Jay, Attila Kovacs, Scot J Matkovich, and Brian J DeBosch. Hepatocyte TFEB attenuates the pathological cardiac response to cardiac injury JCI Insight.