Brian DeBosch, M.D., Ph.D.  debosch_B@kids.wustl.edu

Diabetes Research Center
Gastroenterology, Hepatology and NutritionPathobiology

phone: (314) 454-6173

Clinical Interests

Non-alcoholic fatty liver diseaseObesity

Education

  • B.S., Summa Cum Laude Distinction, University of Michigan2001
  • M.D., Washington University School of Medicine2008
  • Ph.D., Olin Fellowship, Washington University School of Medicine2008

Training

  • Residency, St. Louis Children's Hospital2008 - 2010
  • Fellowship - Accelerated Research Pathway, Washington University School of Medicine2010 - 2014

Licensure and Board Certification

  • Basic Life Support2008
  • Neonatal Resuscitation Program2008
  • Pediatric Advanced Life Support2008
  • American Board of Pediatrics2013
  • MO, Physician & Surgeon License2015
  • Pediatric Gastroenterology, Hepatology & Nutrition2015

Honors

  • National Merit Scholar1997
  • Regents-Alumni Scholar, University of Michigan, Ann Arbor1997
  • UPAAM Outstanding Youth of Michigan Scholar1997
  • Academic Merit Scholar, College of Literature, Science & Arts, University of Michigan, Ann Arbor1997 - 2001
  • Ford Endowed Merit Scholar1997 - 2001
  • James B. Angell Scholar, University of Michigan, Ann Arbor1997 - 2001
  • Class Honors Award, University of Michigan, Ann Arbor1998 - 2001
  • Sophomore Honors Award, University of Michigan, Ann Arbor1999
  • Telluride Association Scholar1999 - 2001
  • Barry M. Goldwater Scholar2000 - 2001
  • Delta Phi Alpha National German Honor Society2001 - Pres
  • National Council on Undergraduate Research Award2001
  • Highest Honors Thesis Distinction, University of Michigan, Ann Arbor2001 - 2001
  • Summa Cum Laude, University of Michigan, Ann Arbor2001 - 2001
  • Triple Crown Award - St. Louis Children's Hospital2011
  • Digestive Diseases Research Center P&F Award2013 - 2015
  • Faculty Scholar - Children's Discovery Institute2014 - Pres
  • Nutrition & Obesity Research Center P&F Award2014 - Pres
  • Scholar - Child Health Research Center of Washington University School of Medicine2014 - Pres
  • Early Investigator Award - the Endocrine Society2015 - Pres
  • American Gastroenterological Association / Gilead Sciences Research Scholars Award in Liver Disease2015 - 2018
  • St. Louis Children's Hosptial Recognition Award2015
  • Robert Wood Johnson Foundation Scholar - Amos Medical Faculty Development Program2016 - Pres
  • United States Department of Defense Discovery Award2017 - Pres

Recent Publications view all (17)


Publication Co-Authors

  1. Mayer AL, Higgins CB, Heitmeier MR, Kraft TE, Qian X, Crowley JR, Hyrc KL, Beatty WL, Yarasheski KE, Hruz PW, DeBosch BJ. SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy. Sci Rep. 2016;6:38586. PMID:27922102  
  2. DeBosch BJ, Heitmeier MR, Mayer AL, Higgins CB, Crowley JR, Kraft TE, Chi M, Newberry EP, Chen Z, Finck BN, Davidson NO, Yarasheski KE, Hruz PW, Moley KH. Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis. Sci Signal. 2016;9(416):ra21. PMCID:PMC4816640  PMID:26905426  
  3. Omurtag K, Esakky P, Debosch BJ, Schoeller EL, Chi MM, Moley KH. Modeling the effect of cigarette smoke on hexose utilization in spermatocytes. Reprod Sci. 2015;22(1):94-101. doi:10.1177/1933719114533727  PMID:24803506  
  4. DeBosch BJ, Kluth O, Fujiwara H, Schürmann A, Moley K. Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9. Nat Commun. 2014;5:4642. doi:10.1038/ncomms5642  PMCID:PMC4348061  PMID:25100214  
  5. Debosch BJ, Chen Z, Saben JL, Finck BN, Moley KH. Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis. J Biol Chem. 2014;289(16):10989-98. doi:10.1074/jbc.M113.527002  PMCID:PMC4036240  PMID:24519932  
  6. DeBosch BJ, Chen Z, Finck BN, Chi M, Moley KH. Glucose transporter-8 (GLUT8) mediates glucose intolerance and dyslipidemia in high-fructose diet-fed male mice. Mol Endocrinol. 2013;27(11):1887-96. doi:10.1210/me.2013-1137  PMCID:PMC3805847  PMID:24030250  
  7. DeBosch BJ, Chi M, Moley KH. Glucose transporter 8 (GLUT8) regulates enterocyte fructose transport and global mammalian fructose utilization. Endocrinology. 2012;153(9):4181-91. doi:10.1210/en.2012-1541  PMCID:PMC3423610  PMID:22822162  
  8. Etzion S, Etzion Y, DeBosch B, Crawford PA, Muslin AJ. Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity. J Mol Cell Cardiol. 2010;49(6):931-40. doi:10.1016/j.yjmcc.2010.08.011  PMCID:PMC2975863  PMID:20728450  
  9. Avery J, Etzion S, DeBosch BJ, Jin X, Lupu TS, Beitinjaneh B, Grand J, Kovacs A, Sambandam N, Muslin AJ. TRB3 function in cardiac endoplasmic reticulum stress. Circ Res. 2010;106(9):1516-23. doi:10.1161/CIRCRESAHA.109.211920  PMCID:PMC2913227  PMID:20360254  
  10. DeBosch BJ, Brown D, Tse G, Hua M, Kodner IJ. Fetus-saving Caesarian rejection by pregnant woman: a case study. Surgery. 2009;145(1):6-8. PMID:19093328  
  11. DeBosch BJ, Muslin AJ. Insulin signaling pathways and cardiac growth. J Mol Cell Cardiol. 2008;44(5):855-64. doi:10.1016/j.yjmcc.2008.03.008  PMCID:PMC2442827  PMID:18423486  
  12. Lau JM, Jin X, Ren J, Avery J, DeBosch BJ, Treskov I, Lupu TS, Kovacs A, Weinheimer C, Muslin AJ. The 14-3-3tau phosphoserine-binding protein is required for cardiomyocyte survival. Mol Cell Biol. 2007;27(4):1455-66. doi:10.1128/MCB.01369-06  PMCID:PMC1800730  PMID:17145769  
  13. DeBosch B, Sambandam N, Weinheimer C, Courtois M, Muslin AJ. Akt2 regulates cardiac metabolism and cardiomyocyte survival. J Biol Chem. 2006;281(43):32841-51. doi:10.1074/jbc.M513087200  PMCID:PMC2724003  PMID:16950770  
  14. DeBosch B, Treskov I, Lupu TS, Weinheimer C, Kovacs A, Courtois M, Muslin AJ. Akt1 is required for physiological cardiac growth. Circulation. 2006;113(17):2097-104. doi:10.1161/CIRCULATIONAHA.105.595231  PMID:16636172  
  15. Muslin AJ, DeBosch B. Role of Akt in cardiac growth and metabolism. Novartis Found Symp. 2006;274:118-26; discussion 126-31, 152-5, 272-6. PMID:17019809  
  16. DeBosch BJ, Deo BK, Kumagai AK. Insulin-like growth factor-1 effects on bovine retinal endothelial cell glucose transport: role of MAP kinase. J Neurochem. 2002;81(4):728-34. PMID:12065632  
  17. DeBosch BJ, Baur E, Deo BK, Hiraoka M, Kumagai AK. Effects of insulin-like growth factor-1 on retinal endothelial cell glucose transport and proliferation. J Neurochem. 2001;77(4):1157-67. PMID:11359881  
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