Department of Pediatrics

Nicole Gilbert, PhD gilbert@wustl.edu

Instructor in Pediatrics, Infectious Diseases

Infectious Diseases

phone: (314) 454-6050

Education

BS, Concordia University Nebraska, 2005
PhD, Saint Louis University School of Medicine, 2010

Training

Postdoc, Washington University School of Medicine, 2011 - 2016

Honors and Awards

Most Outstanding Graduate in Biology and Chemistry, 2005
Saint Louis University Graduate Student Association Research Symposium, Biological Sciences Poster Competition – 2nd place, 2008
American Society of Microbiology, Missouri Branch Annual Meeting. Ph.D. Candidate Research Presentation Competition - 1st place, 2011
Global Health and Infectious Disease Conference Postdoc Poster Competition- 1st place, 2016

Recent Publications view all (21)

Publication Co-Authors

Drew Schwartz, M.D., Ph.D.

Valerie P O'Brien, Amanda L Lewis, Nicole M Gilbert . Bladder Exposure to Gardnerella Activates Host Pathways Necessary for Escherichia coli Recurrent UTI Front Cell Infect Microbiol . . 2021. doi:10.3389/fcimb.2021.788229 PMCID:PMC8685330 PMID:34938672
Nicole M Gilbert, Brian Choi, Jingjie Du, Christina Collins, Amanda L Lewis, Catherine Putonti, Alan J Wolfe . A mouse model displays host and bacterial strain differences in Aerococcus urinae urinary tract infection Biol Open. 2021;10(8). doi:10.1242/bio.058931 PMID:34387311
Gilbert NM, Foster LR, Cao B, Yin Y, Mysorekar IU, Lewis AL. Gardnerella vaginalis promotes group B Streptococcus vaginal colonization, enabling ascending uteroplacental infection in pregnant mice Am J Obstet Gynecol. 2021. doi:10.1016/j.ajog.2020.11.032 PMID:33248136
O'Brien VP, Joens MS, Lewis AL, Gilbert NM. Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice Journal of Visualized Experiments. 2020. doi:10.3791/61967
Kavita Agarwal, Lloyd S Robinson, Somya Aggarwal, Lynne R Foster, Ariel Hernandez-Leyva, Hueylie Lin, Brett A Tortelli, Valerie P O'Brien, Liza Miller, Andrew L Kau, Hilary Reno , Nicole M Gilbert, Warren G Lewis, Amanda L Lewis . Glycan cross-feeding supports mutualism between Fusobacterium and the vaginal microbiota PLoS Biol.. 2020. doi:10.1371/journal.pbio.3000788 PMCID:PMC7447053 PMID:32841232
Hilt EE, Putonti C, Thomas-White K, Lewis AL, Visick KL, Gilbert NM, Wolfe AJ. Aerococcus urinae Isolated from Women with Lower Urinary Tract Symptoms: In Vitro Aggregation and Genome Analysis. J Bacteriol. 2020;202(13). PMCID:PMC7283593 PMID:32284319
Morrill S, Gilbert NM, Lewis AL. Gardnerella vaginalis as a Cause of Bacterial Vaginosis: Appraisal of the Evidence From in vivo Models. Front Cell Infect Microbiol. 2020;10:168. PMCID:PMC7193744 PMID:32391287
Lewis AL, Gilbert NM. Roles of the vagina and the vaginal microbiota in urinary tract infection: evidence from clinical correlations and experimental models. GMS Infect Dis. 2020;8:Doc02. PMCID:PMC7186798 PMID:32373427
Gilbert NM, Lewis WG, Li G, Sojka DK, Lubin JB, Lewis AL. Gardnerella vaginalis and Prevotella bivia Trigger Distinct and Overlapping Phenotypes in a Mouse Model of Bacterial Vaginosis. J Infect Dis. 2019;220(7):1099-1108. PMCID:PMC6736442 PMID:30715405
O'Brien VP, Gilbert NM, Lebratti T, Agarwal K, Foster L, Shin H, Lewis AL. Low-dose inoculation of Escherichia coli achieves robust vaginal colonization and results in ascending infection accompanied by severe uterine inflammation in mice. PLoS One. 2019;14(7):e0219941. PMCID:PMC6645506 PMID:31329630
Gilbert NM, Lewis AL. Covert pathogenesis: Transient exposures to microbes as triggers of disease. PLoS Pathog. 2019;15(3):e1007586. PMCID:PMC6438445 PMID:30921443
Amegashie CP, Gilbert NM, Peipert JF, Allsworth JE, Lewis WG, Lewis AL. Relationship between nugent score and vaginal epithelial exfoliation. PLoS One. 2017;12(5):e0177797. PMCID:PMC5451030 PMID:28562623
Gilbert NM, O'Brien VP, Lewis AL. Transient microbiota exposures activate dormant Escherichia coli infection in the bladder and drive severe outcomes of recurrent disease. PLoS Pathog. 2017;13(3):e1006238. PMCID:PMC5373645 PMID:28358889
Lubin JB, Lewis WG, Gilbert NM, Weimer CM, Almagro-Moreno S, Boyd EF, Lewis AL. Host-like carbohydrates promote bloodstream survival of Vibrio vulnificus in vivo. Infect Immun. 2015;83(8):3126-36. PMCID:PMC4496609 PMID:26015477
Kline KA, Schwartz DJ, Gilbert NM, Lewis AL. Impact of host age and parity on susceptibility to severe urinary tract infection in a murine model. PLoS One. 2014;9(5):e97798. PMCID:PMC4024022 PMID:24835885
Gilbert NM, O'Brien VP, Hultgren S, Macones G, Lewis WG, Lewis AL. Urinary tract infection as a preventable cause of pregnancy complications: opportunities, challenges, and a global call to action. Glob Adv Health Med. 2013;2(5):59-69. PMCID:PMC3833562 PMID:24416696
Lewis WG, Robinson LS, Gilbert NM, Perry JC, Lewis AL. Degradation, foraging, and depletion of mucus sialoglycans by the vagina-adapted Actinobacterium Gardnerella vaginalis. J Biol Chem. 2013;288(17):12067-79. PMCID:PMC3636892 PMID:23479734
Gilbert NM, Lewis WG, Lewis AL. Clinical features of bacterial vaginosis in a murine model of vaginal infection with Gardnerella vaginalis. PLoS One. 2013;8(3):e59539. PMCID:PMC3602284 PMID:23527214
Kline KA, Schwartz DJ, Gilbert NM, Hultgren SJ, Lewis AL. Immune modulation by group B Streptococcus influences host susceptibility to urinary tract infection by uropathogenic Escherichia coli. Infect Immun. 2012;80(12):4186-94. PMCID:PMC3497425 PMID:22988014
Gilbert NM, Baker LG, Specht CA, Lodge JK. A glycosylphosphatidylinositol anchor is required for membrane localization but dispensable for cell wall association of chitin deacetylase 2 in Cryptococcus neoformans. mBio. 2012;3(1). PMCID:PMC3280450 PMID:22354955
Gilbert NM, Donlin MJ, Gerik KJ, Specht CA, Djordjevic JT, Wilson CF, Sorrell TC, Lodge JK. KRE genes are required for beta-1,6-glucan synthesis, maintenance of capsule architecture and cell wall protein anchoring in Cryptococcus neoformans. Mol Microbiol. 2010;76(2):517-34. PMCID:PMC2969852 PMID:20384682

Last updated: 05/10/2022