Department of Pediatrics

Clinical Interests

My clinical interests include diagnosis and management of congenital anomalies of the kidney and urinary tract, chronic kidney disease, hypertension, kidney stones, urinary tract infections, glomerular diseases including nephrotic and nephritic syndromes, and electrolyte disorders. In the acute setting, as part of the dialysis and pheresis team, we provide all modalities of renal replacement therapies and therapeutic plasma exchange.

Education

• BS, Honors and High Distinction, The University of Iowa, 2001
• PhD, The University of Iowa, 2009
• MD, The University of Iowa Carver College of Medicine, 2009

Training

• Resident in Pediatrics, Saint Louis Children's Hospital, 2009 - 2011
• Fellow in Pediatric Nephrology, Washington University School of Medicine, 2011 - 2015

Licensure and Board Certification

• 2012 - PresMO, State Board of Registration for the Healing Arts - Physician and Surgeon
• 2012 - PresAmerican Board of Pediatrics/General Pediatrics
• 2015 - PresIL, Department of Financial and Professional Regulation - Licensed Physician and Surgeon
• 2016 - PresThe American Board of Pediatrics/Pediatric Nephrology

Honors and Awards

• Predoctoral Training Program in Genetics, National Institutes of Health, 5T32GM008629, PI: Jeffrey Murray, M.D., 2005 - 2007
• Caroline tum Suden/Frances A. Hellebrandt Professional Opportunity Award, American Physiological Society, 2007
• Research Day Award for Best Graduate Student Basic Science Poster, Department of Internal Medicine, The University of Iowa Carver College of Medicine, 2007
• Research Week Poster Award, The University of Iowa Carver College of Medicine, 2007
• Merck New Investigator Award, American Heart Association - Council on High Blood Pressure, 2007
• Best Poster Presentation Award, The University of Iowa Genetics Ph.D. Program, 2007
• Dean's Distinguished Dissertation Award, The University of Iowa, 2010
• Postdoctoral Developmental Cardiology and Pulmonary Training Program, National Institutes of Health, 5T32HL007873, PI: Robert Mecham, Ph.D., 2012 - 2014
• Trainee Research Award in Pediatric Nephrology, American Society of Pediatric Nephrology, 2014
• Physician Scientist Training Program, National Institutes of Health, 2T32HD043010, PI: Alan Schwartz, Ph.D., M.D., 2014 - 2015
• Pediatric Physician-Scientist Training Program Fellowship Support, Mallinckrodt Foundation, 2014 - 2015
• Travel Award, American Society for Matrix Biology, 2014
• "Teresa Vietti Fellow" Award, Department of Pediatrics, Washington University School of Medicine, 2015
• Scholar of the Child Health Research Center at Washington University School of Medicine, National Institutes of Health, K12-HD076224, 2015 - 2017
• F. Sessions Cole, M.D. Award in Clinical Excellence 2018, 2018

Recent Publications view all (26)

Publication Co-Authors

Beth A. Kozel, M.D., Ph.D.

Lawrence Salkoff

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Carmen Halabi, M.D., Ph.D.

1. Spears LD, Adak S, Dong G, Wei X, Spyropoulos G, Zhang Q, Yin L, Feng C, Hu D, Lodhi IJ, Hsu FF, Rajagopal R, Noguchi KK, Halabi CM, Brier L, Bice AR, Lananna BV, Musiek ES, Avraham O, Cavalli V, Holth JK, Holtzman DM, Wozniak DF, Culver JP, Semenkovich CF. Endothelial ether lipids link the vasculature to blood pressure, behavior, and neurodegeneration. J Lipid Res. 2021;62:100079. PMCID:PMC8144742  PMID:33894211 
2. Troia A, Knutsen RH, Halabi CM, Malide D, Yu ZX, Wardlaw-Pickett A, Kronquist EK, Tsang KM, Kovacs A, Mecham RP, Kozel BA. Inhibition of NOX1 Mitigates Blood Pressure Increases in Elastin Insufficiency. Function (Oxf). 2021;2(3):zqab015. PMCID:PMC8248879  PMID:34223172 
3. Kabir AU, Subramanian M, Lee DH, Wang X, Krchma K, Wu J, Naismith T, Halabi CM, Kim JY, Pulous FE, Petrich BG, Kim S, Park HC, Hanson PI, Pan H, Wickline SA, Fremont DH, Park C, Choi K. Dual role of endothelial Myct1 in tumor angiogenesis and tumor immunity. Sci Transl Med. 2021;13(583). PMID:33658356 
4. Halabi CM, Hulbert ML. Sickle cell disease-Under pressure. Pediatr Blood Cancer. 2021;e28932. PMID:33559325 
5. Zhang H, Hanson AM, Scherf de Almeida TU, Emfinger CH, McClenaghan C, Harter T, Yan Z, Cooper PE, Brown GS, Arakel EC, Mecham RP, Kovacs A, Halabi CM, Schwappach B, Remedi MS, Nichols CG. Complex consequences of Cantu Syndrome SUR2 variant R1154Q in genetically modified mice. JCI Insight. 2021. PMID:33529173 
6. Halabi CM, Kozel BA. Vascular elastic fiber heterogeneity in health and disease. Curr Opin Hematol. 2020;27(3):190-196. PMID:32141894 
7. McClenaghan C, Huang Y, Yan Z, Harter T, Halabi CM, Chalk R, Kovacs A, van Haaften G, Remedi MS, Nichols CG. Glibenclamide reverses cardiovascular abnormalities of Cantu Syndrome driven by KATP channel overactivity. J Clin Invest. 2019. PMID:31821173 
8. Li P, Halabi CM, Stewart R, Butler A, Brown B, Xia X, Santi C, England S, Ferreira J, Mecham RP, Salkoff L. Sodium-activated potassium channels moderate excitability in vascular smooth muscle. J Physiol. 2019. PMID:31444905 
9. Lee VS, Halabi CM, Broekelmann TJ, Trackman PC, Stitziel NO, Mecham RP. Intracellular retention of mutant lysyl oxidase leads to aortic dilation in response to increased hemodynamic stress. JCI Insight. 2019;5. PMID:31211696 
10. Huang Y, McClenaghan C, Harter TM, Hinman K, Halabi CM, Matkovich SJ, Zhang H, Brown GS, Mecham RP, England SK, Kovacs A, Remedi MS, Nichols CG. Cardiovascular consequences of KATP overactivity in Cantu syndrome. JCI Insight. 2018;3(15). PMID:30089727 
11. Shepherd AJ, Mickle AD, Golden JP, Mack MR, Halabi CM, de Kloet AD, Samineni VK, Kim BS, Krause EG, Gereau RW 4th, Mohapatra DP. Macrophage angiotensin II type 2 receptor triggers neuropathic pain. Proc Natl Acad Sci U S A. 2018. PMID:30082378 
12. Halabi CM, Mecham RP. Elastin purification and solubilization. Methods Cell Biol. 2018;143:207-222. PMID:29310779 
13. Halabi CM, Broekelmann TJ, Lin M, Lee VS, Chu ML, Mecham RP. Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries. Sci Adv. 2017;3(5):e1602532. PMCID:PMC5415335  PMID:28508064 
14. McAlister AE, Geile K, Halabi CM, Davis TK. In tandem extracorporeal therapies during hemodialysis in pediatric patients. Hemodial Int. 2016;20 Suppl 1:S40-S43. PMID:27669548 
15. Lee VS, Halabi CM, Hoffman EP, Carmichael N, Leshchiner I, Lian CG, Bierhals AJ, Vuzman D, Brigham Genomic Medicine, Mecham RP, Frank NY, Stitziel NO. Loss of function mutation in LOX causes thoracic aortic aneurysm and dissection in humans. Proc Natl Acad Sci U S A. 2016;113(31):8759-64. PMID:27432961 
16. Halabi CM, Broekelmann TJ, Knutsen RH, Ye L, Mecham RP, Kozel BA. Chronic antihypertensive treatment improves pulse pressure but not large artery mechanics in a mouse model of congenital vascular stiffness. Am J Physiol Heart Circ Physiol. 2015;309(5):H1008-16. doi:10.1152/ajpheart.00288.2015  PMID:26232234 
17. Igoucheva O, Alexeev V, Halabi CM, Adams SM, Stoilov I, Sasaki T, Arita M, Donahue A, Mecham RP, Birk DE, Chu ML. Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with both Elastic Fiber and Collagen Fibril Abnormalities. J Biol Chem. 2015;290(35):21443-59. doi:10.1074/jbc.M115.640425  PMID:26178373 
18. Davis TK, Halabi CM, Siefken P, Karmarkar S, Leonard J. Aggressive blood pressure control for chronic kidney disease unmasks moyamoya! Clin Kidney J. 2013;6(5):495-9. doi:10.1093/ckj/sft090  PMCID:PMC4438405  PMID:26064513 
19. Keen HL, Halabi CM, Beyer AM, de Lange WJ, Liu X, Maeda N, Faraci FM, Casavant TL, Sigmund CD. Bioinformatic analysis of gene sets regulated by ligand-activated and dominant-negative peroxisome proliferator-activated receptor gamma in mouse aorta. Arterioscler Thromb Vasc Biol. 2010;30(3):518-25. doi:10.1161/ATVBAHA.109.200733  PMCID:PMC2850258  PMID:20018933 
20. Feng Y, Xia H, Cai Y, Halabi CM, Becker LK, Santos RA, Speth RC, Sigmund CD, Lazartigues E. Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension. Circ Res. 2010;106(2):373-82. doi:10.1161/CIRCRESAHA.109.208645  PMCID:PMC2818798  PMID:19926873 
21. de Lange WJ, Halabi CM, Beyer AM, Sigmund CD. Germ line activation of the Tie2 and SMMHC promoters causes noncell-specific deletion of floxed alleles. Physiol Genomics. 2008;35(1):1-4. doi:10.1152/physiolgenomics.90284.2008  PMCID:PMC2574738  PMID:18612081 
22. Beyer AM, de Lange WJ, Halabi CM, Modrick ML, Keen HL, Faraci FM, Sigmund CD. Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet. Circ Res. 2008;103(6):654-61. doi:10.1161/CIRCRESAHA.108.176339  PMCID:PMC2583077  PMID:18676352 
23. Beyer AM, Baumbach GL, Halabi CM, Modrick ML, Lynch CM, Gerhold TD, Ghoneim SM, de Lange WJ, Keen HL, Tsai YS, Maeda N, Sigmund CD, Faraci FM. Interference with PPARgamma signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling. Hypertension. 2008;51(4):867-71. doi:10.1161/HYPERTENSIONAHA.107.103648  PMCID:PMC2408877  PMID:18285614 
24. Halabi CM, Beyer AM, de Lange WJ, Keen HL, Baumbach GL, Faraci FM, Sigmund CD. Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension. Cell Metab. 2008;7(3):215-26. doi:10.1016/j.cmet.2007.12.008  PMCID:PMC2275166  PMID:18316027 
25. McCray PB Jr, Pewe L, Wohlford-Lenane C, Hickey M, Manzel L, Shi L, Netland J, Jia HP, Halabi C, Sigmund CD, Meyerholz DK, Kirby P, Look DC, Perlman S. Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol. 2007;81(2):813-21. doi:10.1128/JVI.02012-06  PMCID:PMC1797474  PMID:17079315 
26. Halabi CM, Sigmund CD. Peroxisome proliferator-activated receptor-gamma and its agonists in hypertension and atherosclerosis : mechanisms and clinical implications. Am J Cardiovasc Drugs. 2005;5(6):389-98. PMID:16259527