Department of Pediatrics

Clinical Interests

As the director of the Sickle Cell Disease Program at St. Louis Children's Hospital, my goal is to ensure that children with sickle cell disease (SCD) receive optimal medical care, including both management of symptoms of SCD as well as treatments that lessen the severity of the disease. The Sickle Cell Disease Team includes physicians, nurses, nurse practitioners, social work, psychology, and other professionals who contribute to the inpatient and outpatient care of children and young adults with SCD.

Education

• BS, Indiana University, 1996
• MD, Washington University School of Medicine, 2000

Training

• Residency in Pediatrics, St. Louis Children's Hospital, 2000 - 2003
• Fellowship in Pediatric Hematology/Oncology, Washington University School of Medicine, 2003 - 2006

Licensure and Board Certification

• 2006 - 2013IN, Medical Licensing Board
• 2006 - 2016American Board of Pediatrics
• 2009 - 2023American Board of Pediatrics, Subboard of Pediatric Hematology-Oncology
• 2011 - PresMO, Board of Registration for the Healing Arts
• 2019 - PresIL, Department of Financial and Professional Regulation

Honors and Awards

• Best Doctors in St. Louis, 2015 - Pres

Recent Publications view all (26)

Publication Co-Authors

Fields, Melanie

Shalini Shenoy, M.D.

Jonathan Mullin

Ronald Jackups, Jr., M.D., Ph.D.

Andrew Cluster

Allison King, M.D., M.P.H., Ph.D.

David B. Wilson, M.D., Ph.D.

Alok Kothari, M.D.

Kristin Guilliams, MD MSCI

Robert J. Hayashi, M.D.

Philip C. Spinella, M.D., FCCM

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Monica Hulbert, M.D.

1. Ngwube A, Shah N, Godder K, Jacobsohn D, Hulbert ML, Shenoy S. Abatacept is effective as GVHD prophylaxis in unrelated donor stem cell transplantation for children with severe sickle cell disease Blood Advances. 2020;4(16):3894-3899. doi:10.1182/bloodadvances.2020002236  PMCID:PMC7448594  PMID:32813873 
2. Hood AM, King AA, Fields ME, Ford AL, Guilliams KP, Hulbert ML, Lee JM, White DA. Higher executive abilities following a blood transfusion in children and young adults with sickle cell disease. Pediatr Blood Cancer. 2019;66(10):e27899. doi:10.1002/pbc.27899  PMCID:PMC6707832  PMID:31267645 
3. Fields ME, Guilliams KP, Ragan D, Binkley MM, Mirro A, Fellah S, Hulbert ML, Blinder M, Eldeniz C, Vo K, Shimony JS, Chen Y, McKinstry RC, An H, Lee JM, Ford AL. Hydroxyurea reduces cerebral metabolic stress in patients with sickle cell anemia. Blood. 2019;133(22):2436-2444. PMCID:PMC6543515  PMID:30858231 
4. Towerman AS, Hayashi SS, Hayashi RJ, Hulbert ML. Prevalence and nature of hearing loss in a cohort of children with sickle cell disease. Pediatr Blood Cancer. 2019;66(1):e27457. PMID:30207054 
5. Fields ME, Guilliams KP, Ragan DK, Binkley MM, Eldeniz C, Chen Y, Hulbert ML, McKinstry RC, Shimony JS, Vo KD, Doctor A, An H, Ford AL, Lee JM. Regional oxygen extraction predicts border zone vulnerability to stroke in sickle cell disease. Neurology. 2018;90(13):e1134-e1142. PMCID:PMC5880632  PMID:29500287 
6. Guilliams KP, Fields ME, Ragan DK, Eldeniz C, Binkley MM, Chen Y, Comiskey LS, Doctor A, Hulbert ML, Shimony JS, Vo KD, McKinstry RC, An H, Lee JM, Ford AL. Red cell exchange transfusions lower cerebral blood flow and oxygen extraction fraction in pediatric sickle cell anemia. Blood. 2017;131(9):1012-1021. PMID:29255068 
7. Panepinto JA, Paul Scott J, Badaki-Makun O, Darbari DS, Chumpitazi CE, Airewele GE, Ellison AM, Smith-Whitley K, Mahajan P, Sarnaik SA, Charles Casper T, Cook LJ, Leonard J, Hulbert ML, Powell EC, Liem RI, Hickey R, Krishnamurti L, Hillery CA, Brousseau DC, Pediatric Emergency Care Applied Research Network (PECARN).. Determining the longitudinal validity and meaningful differences in HRQL of the PedsQL™ Sickle Cell Disease Module. Health Qual Life Outcomes. 2017;15(1):124. PMCID:PMC5468970  PMID:28606098 
8. Abraham A, Cluster A, Jacobsohn D, Delgado D, Hulbert ML, Kukadiya D, Murray L, Shenoy S. Unrelated Umbilical Cord Blood Transplantation for Sickle Cell Disease Following Reduced Intensity Conditioning: Results of a Phase I Trial. Biol Blood Marrow Transplant. 2017;23(9):1587-1592. PMID:28578010 
9. Woods D, Hayashi RJ, Binkley MM, Sparks GW, Hulbert ML. Increased complications of chronic erythrocytapheresis compared with manual exchange transfusions in children and adolescents with sickle cell disease. Pediatr Blood Cancer. 2017;64:e26635. PMID:28544309 
10. Hulbert ML, Panepinto JA, Scott JP, Liem RI, Cook LJ, Simmons T, Brousseau DC, Pediatric Emergency Care and Research Network Sickle Cell Disease Working Group. Red blood cell transfusions during sickle cell anemia vaso-occlusive crises: a report from the magnesium in crisis (MAGiC) study. Transfusion. 2017;57(8):1891-1897. PMID:28500682 
11. Guilliams KP, Fields ME, Ragan DK, Chen Y, Eldeniz C, Hulbert ML, Binkley MM, Rhodes JN, Shimony JS, McKinstry RC, Vo KD, An H, Lee JM, Ford AL. Large-Vessel Vasculopathy in Children With Sickle Cell Disease: A Magnetic Resonance Imaging Study of Infarct Topography and Focal Atrophy. Pediatr Neurol. 2017;69:49-57. PMCID:PMC5365370  PMID:28159432 
12. Hall EM, Leonard J, Smith JL, Guilliams KP, Binkley M, Fallon RJ, Hulbert ML. Reduction in Overt and Silent Stroke Recurrence Rate Following Cerebral Revascularization Surgery in Children with Sickle Cell Disease and Severe Cerebral Vasculopathy. Pediatr Blood Cancer. 2016;63(8):1431-7. PMID:27106860 
13. Brousseau DC, Scott JP, Badaki-Makun O, Darbari DS, Chumpitazi CE, Airewele GE, Ellison AM, Smith-Whitley K, Mahajan P, Sarnaik SA, Casper TC, Cook LJ, Dean JM, Leonard J, Hulbert ML, Powell EC, Liem RI, Hickey R, Krishnamurti L, Hillery CA, Nimmer M, Panepinto JA, Pediatric Emergency Care Applied Research Network (PECARN). A multicenter randomized controlled trial of intravenous magnesium for sickle cell pain crisis in children. Blood. 2015;126(14):1651-1657. doi:10.1182/blood-2015-05-647107  PMID:26232172 
14. Fields ME, Hulbert ML, Chen L, Berlin AN, Jackups R, Spinella PC. Red blood cell storage duration is not associated with clinical outcomes for acute chest syndrome in children with sickle cell disease. Transfusion. 2015;55(11):2714-2721. doi:10.1111/trf.13176  PMID:26033266 
15. Kothari A, Hulbert ML, Cottrell CE, Nguyen TT. Aggressive congenital juvenile myelomonocytic leukemia associated with somatic KRAS p.G13D mutation and concurrent germline IGF1R duplication. Leuk Lymphoma. 2015;56(4):1175-8. doi:10.3109/10428194.2014.953152  PMID:25110823 
16. Beverung LM, Strouse JJ, Hulbert ML, Neville K, Liem RI, Inusa B, Fuh B, King A, Meier ER, Casella J, DeBaun MR, Panepinto JA, SIT trial investigators. Health-related quality of life in children with sickle cell anemia: impact of blood transfusion therapy. Am J Hematol. 2015;90(2):139-43. doi:10.1002/ajh.23877  PMCID:PMC4304929  PMID:25345798 
17. Guilliams KP, Fields ME, Hulbert ML. Higher-than-expected prevalence of silent cerebral infarcts in children with hemoglobin SC disease. Blood. 2015;125(2):416-7. doi:10.1182/blood-2014-10-605964  PMID:25573975 
18. Fasano RM, Meier ER, Hulbert ML. Cerebral vasculopathy in children with sickle cell anemia. Blood Cells Mol Dis. 2015;54(1):17-25. doi:10.1016/j.bcmd.2014.08.007  PMID:25294561 
19. Creary S, Heiny M, Croop J, Fallon R, Vik T, Hulbert M, Knoderer H, Kumar M, Sharathkumar A. Clinical course of postthrombotic syndrome in children with history of venous thromboembolism. Blood Coagul Fibrinolysis. 2012;23(1):39-44. doi:10.1097/MBC.0b013e32834bdb1c  PMID:22089938 
20. Skiles JL, Imel EA, Christenson JC, Bell JE, Hulbert ML. Fluorosis because of prolonged voriconazole therapy in a teenager with acute myelogenous leukemia. J Clin Oncol. 2011;29(32):e779-82. doi:10.1200/JCO.2011.35.9604  PMID:21969513 
21. Hulbert ML, McKinstry RC, Lacey JL, Moran CJ, Panepinto JA, Thompson AA, Sarnaik SA, Woods GM, Casella JF, Inusa B, Howard J, Kirkham FJ, Anie KA, Mullin JE, Ichord R, Noetzel M, Yan Y, Rodeghier M, Debaun MR. Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease. Blood. 2011;117(3):772-9. doi:10.1182/blood-2010-01-261123  PMCID:PMC3035071  PMID:20940417 
22. Rao A, Hulbert M, Wilson DB. Severe hypertriglyceridemia in an infant with red cell pyruvate kinase deficiency. Indian Pediatr. 2007;44(4):303-5. PMID:17468529 
23. Strouse JJ, Hulbert ML, DeBaun MR, Jordan LC, Casella JF. Primary hemorrhagic stroke in children with sickle cell disease is associated with recent transfusion and use of corticosteroids. Pediatrics. 2006;118(5):1916-24. doi:10.1542/peds.2006-1241  PMID:17079562 
24. Hulbert ML, Scothorn DJ, Panepinto JA, Scott JP, Buchanan GR, Sarnaik S, Fallon R, Chu JY, Wang W, Casella JF, Resar L, Berman B, Adamkiewicz T, Hsu LL, Smith-Whitley K, Mahoney D, Woods G, Watanabe M, DeBaun MR. Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: a retrospective cohort study of 137 children with sickle cell anemia. J Pediatr. 2006;149(5):710-2. doi:10.1016/j.jpeds.2006.06.037  PMID:17095350 
25. Ogden MA, White FV, Hulbert ML, Herrmann BW. Pathology quiz case 1. Cervical neuroblastoma (NB). Arch Otolaryngol Head Neck Surg. 2005;131(2):172, 174. doi:10.1001/archotol.131.2.172  PMID:15723954 
26. Wilson DB, Rao A, Hulbert M, Mychaliska KP, Luchtman-Jones L, Hill DA, Foglia RP. Neutropenic enterocolitis as a presenting complication of acute lymphoblastic leukemia: an unusual case marked by delayed perforation of the descending colon. J Pediatr Surg. 2004;39(7):e18-20. PMID:15213940