Jeffrey Magee, M.D., Ph.D.  Magee_J@kids.wustl.edu

Assistant Professor, Division of Hematology-Oncology, Department of Pediatrics
Developmental BiologyHematology and Oncology

phone: (314) 454-6018

Education

  • B.S., University of Wisconsin1997
  • M.D., Washington University, School of Medicine2005
  • Ph.D., Washington University, School of Medicine2005

Training

  • Residency, University of Michigan Hospitals and Health Centers2005 - 2007
  • Fellowship, University of Michigan Hospitals and Health Centers2007 - 2010

Licensure and Board Certification

  • Pediatric Advanced Life Support
  • General Pediatrics, # 952462009
  • MI, Michigan Medical Board2009
  • Pediatric Hematology/Oncology, # 24092011
  • TX, Texas Medical Board2011
  • MO, Missouri Board of Registration for the Healing Arts2013

Honors

  • Hilldale Undergraduate/Faculty Research Fellowship, University of Wisconsin-Madison1995
  • Barry M. Goldwater Scholarship, University of Wisconsin-Madison1996
  • Howard Hughes Medical Institute Fellowship, University of Wisconsin-Madison1996
  • I. Jerome Flance Medical Science Traineeship, Washington University School of Medicine1999
  • American College of Physicians Award for Excellence in Physical Diagnosis, Washington University School of Medicine2000
  • Outstanding Teaching Assistant, Washington University School of Medicine2000
  • David M. Kipnis Thesis Award, Washington University School of Medicine2005
  • Spencer T. and Ann W. Olin Medical Science Fellowship, Washington University School of Medicine2005
  • Pediatric Scientist Development Program Fellowship, University of Michigan Medical School2008
  • Laurence Carolin Award, University of Michigan Medical School2010
  • UT-Southwestern Disease Oriented Clinical Scholar Fellowship (declined)2013
  • Children's Discovery Institute Faculty Scholar2014
  • St. Baldrick's Scholar Award2014
  • Gabrielle's Angel Medical Research Award2016
  • V Foundation Scholar Award2016

Recent Publications view all (17)


Publication Co-Authors

  1. Porter SN, Cluster AS, Yang W, Busken KA, Patel RM, Ryoo JA, Magee JA. Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations. Elife. 2016;5. PMID:27879203  
  2. Magee JA. Comment on: Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia. Br J Haematol. 2016. PMID:27766614  
  3. Porter SN, Cluster AS, Signer RAJ, Voigtman J, Monlish DA, Schuettpelz LG, Magee JA. Pten cell autonomously modulates the hematopoietic stem cell response to inflammatory cytokines Stem Cell Reports. 2016;6(6):806-814. PMID:27185281  
  4. Kraus M, Dolinski B, Rosahl TW, Magee JA. Protein kinase N3 deficiency impedes PI3-kinase pathway-driven leukemogenesis without affecting normal hematopoiesis. Leukemia. 2015;29(1):255-8. doi:10.1038/leu.2014.278  PMID:25234167  
  5. Signer RA, Magee JA, Salic A, Morrison SJ. Haematopoietic stem cells require a highly regulated protein synthesis rate. Nature. 2014;509(7498):49-54. doi:10.1038/nature13035  PMCID:PMC4015626  PMID:24670665  
  6. Li Q, Bohin N, Wen T, Ng V, Magee J, Chen SC, Shannon K, Morrison SJ. Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness. Nature. 2013;504(7478):143-7. doi:10.1038/nature12830  PMID:24284627  
  7. Foley SB, Hildenbrand ZL, Soyombo AA, Magee JA, Wu Y, Oravecz-Wilson KI, Ross TS. Expression of BCR/ABL p210 from a knockin allele enhances bone marrow engraftment without inducing neoplasia. Cell Rep. 2013;5(1):51-60. doi:10.1016/j.celrep.2013.08.037  PMCID:PMC3832111  PMID:24095735  
  8. Magee JA, Ikenoue T, Nakada D, Lee JY, Guan KL, Morrison SJ. Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. Cell Stem Cell. 2012;11(3):415-28. doi:10.1016/j.stem.2012.05.026  PMCID:PMC3447536  PMID:22958933  
  9. Magee JA, Piskounova E, Morrison SJ. Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell. 2012;21(3):283-96. doi:10.1016/j.ccr.2012.03.003  PMID:22439924  
  10. Chang LW, Nagarajan R, Magee JA, Milbrandt J, Stormo GD. A systematic model to predict transcriptional regulatory mechanisms based on overrepresentation of transcription factor binding profiles. Genome Res. 2006;16(3):405-13. doi:10.1101/gr.4303406  PMCID:PMC1415218  PMID:16449500  
  11. Magee JA, Chang LW, Stormo GD, Milbrandt J. Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element. Endocrinology. 2006;147(1):590-8. doi:10.1210/en.2005-1001  PMID:16210365  
  12. Magee JA, Abdulkadir SA, Milbrandt J. Haploinsufficiency at the Nkx3.1 locus. A paradigm for stochastic, dosage-sensitive gene regulation during tumor initiation. Cancer Cell. 2003;3(3):273-83. PMID:12676585  
  13. Abdulkadir SA, Magee JA, Peters TJ, Kaleem Z, Naughton CK, Humphrey PA, Milbrandt J. Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Mol Cell Biol. 2002;22(5):1495-503. PMCID:PMC134699  PMID:11839815  
  14. Magee J, Gordon JI, Whelan A. Bringing the human genome and the revolution in bioinformatics to the medical school classroom: a case report from Washington University School of Medicine. Acad Med. 2001;76(8):852-5. PMID:11500292  
  15. Magee JA, Araki T, Patil S, Ehrig T, True L, Humphrey PA, Catalona WJ, Watson MA, Milbrandt J. Expression profiling reveals hepsin overexpression in prostate cancer. Cancer Res. 2001;61(15):5692-6. PMID:11479199  
  16. Kim J, Magee J, Carroll SB. Intercompartmental signaling and the regulation of vestigial expression at the dorsoventral boundary of the developing Drosophila wing. Cold Spring Harb Symp Quant Biol. 1997;62:283-91. PMID:9598362  
  17. Kim J, Sebring A, Esch JJ, Kraus ME, Vorwerk K, Magee J, Carroll SB. Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene. Nature. 1996;382(6587):133-8. doi:10.1038/382133a0  PMID:8700202  
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