Department of Pediatrics

Clinical Interests

Dr. Sprague’s clinical interests include pediatric diabetes (type 1 and type 2) and general endocrine disorders (disorders of growth, puberty, thyroid and adrenal disease). She has a particular interest in endocrine complications of obesity including type 2 diabetes, metabolic syndrome and polycystic ovary syndrome (PCOS). Dr. Sprague is active in the type 2 diabetes education and care program at St. Louis Children’s Hospital. She has a focus on patient education, patient centered outcomes and quality improvement.

Education

• BS, Highest Honors, Indiana University, 2000
• MD, Washington University School of Medicine, 2007
• PhD, Washington UNiversity School of Medicine, 2007

Training

• Pediatrics Residency, St. Louis Children's Hospital, 2007 - 2010
• Pediatric Endocrinology Fellowship, Washington University, 2010 - 2013

Licensure and Board Certification

• MO, Medicine , 2010
• General Pediatrics , 2010
• Pediatric Endocrinology , 2013

Honors

• National Starch & Chemical Scholarship, 1997 - 1998
• Lubrizol Scholarship in Chemistry, 1998 - 1999
• Ronald E. McNair Post-baccalaureate Achievement Program, 1999 - 2000
• Triple Crown Award - St. Louis Children's Hospital, Children's Direct, 2012
• Best Abstract in Basic Research - Department of Pediatrics Research Retreat, 2013

Recent Publications view all (8)

Publication Co-Authors

Ana María Arbeláez, M.D. MSCI

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Jennifer Sprague, M.D., Ph.D.

1. Weng S, Sprague JE, Oh J, Riek AE, Chin K, Garcia M, Bernal-Mizrachi C. Vitamin D deficiency induces high blood pressure and accelerates atherosclerosis in mice. PLoS One. 2013;8(1):e54625. doi:10.1371/journal.pone.0054625  PMCID:PMC3551761  PMID:23349943 
2. Riek AE, Oh J, Sprague JE, Timpson A, de las Fuentes L, Bernal-Mizrachi L, Schechtman KB, Bernal-Mizrachi C. Vitamin D suppression of endoplasmic reticulum stress promotes an antiatherogenic monocyte/macrophage phenotype in type 2 diabetic patients. J Biol Chem. 2012;287(46):38482-94. doi:10.1074/jbc.M112.386912  PMCID:PMC3493893  PMID:23012375 
3. Sprague JE, Arbeláez AM. Glucose counterregulatory responses to hypoglycemia. Pediatr Endocrinol Rev. 2011;9(1):463-73; quiz 474-5. PMID:22783644 
4. Wadas TJ, Deng H, Sprague JE, Zheleznyak A, Weilbaecher KN, Anderson CJ. Targeting the alphavbeta3 integrin for small-animal PET/CT of osteolytic bone metastases. J Nucl Med. 2009;50(11):1873-80. doi:10.2967/jnumed.109.067140  PMCID:PMC2836828  PMID:19875645 
5. Sprague JE, Peng Y, Fiamengo AL, Woodin KS, Southwick EA, Weisman GR, Wong EH, Golen JA, Rheingold AL, Anderson CJ. Synthesis, characterization and in vivo studies of Cu(II)-64-labeled cross-bridged tetraazamacrocycle-amide complexes as models of peptide conjugate imaging agents. J Med Chem. 2007;50(10):2527-35. doi:10.1021/jm070204r  PMID:17458949 
6. Sprague JE, Kitaura H, Zou W, Ye Y, Achilefu S, Weilbaecher KN, Teitelbaum SL, Anderson CJ. Noninvasive imaging of osteoclasts in parathyroid hormone-induced osteolysis using a 64Cu-labeled RGD peptide. J Nucl Med. 2007;48(2):311-8. PMCID:PMC2711534  PMID:17268030 
7. Sprague JE, Li WP, Liang K, Achilefu S, Anderson CJ. In vitro and in vivo investigation of matrix metalloproteinase expression in metastatic tumor models. Nucl Med Biol. 2006;33(2):227-37. doi:10.1016/j.nucmedbio.2005.10.011  PMID:16546677 
8. Sprague JE, Peng Y, Sun X, Weisman GR, Wong EH, Achilefu S, Anderson CJ. Preparation and biological evaluation of copper-64-labeled tyr3-octreotate using a cross-bridged macrocyclic chelator. Clin Cancer Res. 2004;10(24):8674-82. doi:10.1158/1078-0432.CCR-04-1084  PMID:15623652