Clinical Interests

Genetic regulation of neonatal pulmonary surfactant deficiency has been suggested by studies of gender, genetic linkage, recurrent familial cases, targeted gene ablation in murine lineages, and by racial disparity in risk of neonatal respiratory distress syndrome. Successful fetal-neonatal pulmonary transition requires production of the pulmonary surfactant, a phospholipid-protein film that lines alveoli and maintains alveolar patency at end expiration. Our goal is to understand the genetic mechanisms that disrupt pulmonary surfactant metabolism and cause neonatal respiratory distress syndrome

Education

  • B.A., Amherst College1969
  • M.D., Yale School of Medicine1973

Training

  • Clinical Fellow in Pediatrics, Harvard Medical School1973 - 1974
  • Internship, Boston Children’s Hospital/Harvard Medical School1973 - 1974
  • Residency, Boston Children’s Hospital/Harvard Medical School1976 - 1978
  • Clinical Fellow in Pediatrics, Harvard Medical School1976 - 1978
  • Research Fellow in Pediatrics, Harvard Medical School1978 - 1980
  • Research Fellow, Neonatology and Cell Biology, the Joint Program in Neonatology, Brigham and Women's Hospital1978 - 1981

Licensure and Board Certification

  • National Board of Medical Examiners, #1340031973
  • MA, 1975
  • American Board of Pediatrics #239151980
  • American Board of Neonatal-Perinatal Medicine (#1141)1983
  • MO, 1986

Honors

  • Alpha Omega Alpha, Yale University School of Medicine1973
  • M.D., cum laude, Yale University School of Medicine1973
  • 37th Annual Alpha Omega Alpha Lecturer, Washington University School of Medicine1990
  • Clinical Teacher of the Year Award, Washington University School of Medicine1993
  • Invited plenary session speaker, 14th European Congress of Perinatal Medicine, Helsinki, Finland1994
  • FDR Leadership Award from the March of Dimes (co-winner with Senator Christopher Bond, Senior Senator from Missouri)1997
  • Distinguished Faculty Award-Founder's Day, Washington University1997
  • Named the Park J. White, M.D., Professor of Pediatrics1998
  • Distinguished Service Teaching Award, Washington University School of Medicine Class of 20011998
  • Clinical Teaching Award, Washington University School of Medicine Class of 20001999
  • Torch of Youth Award, National Council on Youth Leadership1999
  • Cartíer First Aide Award, St. Louis Effort For AIDS2000
  • Washington University Nominee for the Pfizer Humanism in Medicine Award2003
  • Distinguished Service Teaching Award, Washington University School of Medicine, Class of 20072004
  • Washington University School of Medicine Distinguished Faculty Award Recipient for Distinguished Community Service2009
  • Princeton Award from the Princeton Club of St. Louis in recognition of outstanding leadership in service to the community2010
  • Washington University School of Medicine Samuel R. Goldstein Leadership Award in Medical Education2010
  • Distinguished Service Award from the Washington University Medical Center Alumni Association2013
  • Washington University School of Medicine 2nd Century Award2014
  • Distinguished Alumnus Award, Moses Brown School, Providence, Rhode Island2015
  • Founder's Award - Midwest Society for Pediatric Research (MWSPR)2016

Recent Publications view all (103)


  1. Wambach JA, Yang P, Wegner DJ, Heins HB, Kaliberova LN, Kaliberov SA, Curiel DT, White FV, Hamvas A, Hackett BP, Cole FS. Functional Characterization of ABCA3 Mutations from Infants with Respiratory Distress Syndrome. Am J Respir Cell Mol Biol. 2016. PMID:27374344  
  2. Ng BG, Shiryaev SA, Rymen D, Eklund EA, Raymond K, Kircher M, Abdenur JE, Alehan F, Midro AT, Bamshad MJ, Barone R, Berry GT, Brumbaugh JE, Buckingham KJ, Clarkson K, Cole FS, O'Connor S, Cooper GM, Van Coster R, Demmer LA, Diogo L, Fay AJ, Ficicioglu C, Fiumara A, Gahl WA, Ganetzky R, Goel H, Harshman LA, He M, Jaeken J, James PM, Katz D, Keldermans L, Kibaek M, Kornberg AJ, Lachlan K, Lam C, Yaplito-Lee J, Nickerson DA, Peters HL, Race V, Régal L, Rush JS, Rutledge SL, Shendure J, Souche E, Sparks SE, Trapane P, Sanchez-Valle A, Vilain E, Vøllo A, Waechter CJ, Wang RY, Wolfe LA, Wong DA, Wood T, Yang AC, University of Washington Center for Mendelian Genomics, Matthijs G, Freeze HH. ALG1-CDG: Clinical and Molecular Characterization of 39 Unreported Patients. Hum Mutat. 2016;37(7):653-60. PMCID:PMC4907823  PMID:26931382  
  3. Shen CL, Zhang Q, Meyer Hudson J, Cole FS, Wambach JA. Genetic Factors Contribute to Risk for Neonatal Respiratory Distress Syndrome among Moderately Preterm, Late Preterm, and Term Infants. J Pediatr. 2016;172:69-74.e2. PMCID:PMC4876036  PMID:26935785  
  4. Chen YJ, Wambach JA, DePass K, Wegner DJ, Chen SK, Zhang QY, Heins H, Cole FS, Hamvas A. Population-based frequency of surfactant dysfunction mutations in a native Chinese cohort. World J Pediatr. 2016;12(2):190-5. PMID:26547207  
  5. Jackson T, Wegner DJ, White FV, Hamvas A, Cole FS, Wambach JA. Respiratory failure in a term infant with cis and trans mutations in ABCA3. J Perinatol. 2015;35(3):231-2. doi:10.1038/jp.2014.236  PMCID:PMC4341920  PMID:25712598  
  6. Vesoulis ZA, Attarian SJ, Zeller B, Cole FS. Minoxidil-associated anorexia in an infant with refractory hypertension. Pharmacotherapy. 2014;34(12):e341-4. doi:10.1002/phar.1495  PMID:25280267  
  7. Starmer AJ, Spector ND, Srivastava R, West DC, Rosenbluth G, Allen AD, Noble EL, Tse LL, Dalal AK, Keohane CA, Lipsitz SR, Rothschild JM, Wien MF, Yoon CS, Zigmont KR, Wilson KM, O'Toole JK, Solan LG, Aylor M, Bismilla Z, Coffey M, Mahant S, Blankenburg RL, Destino LA, Everhart JL, Patel SJ, Bale JF Jr, Spackman JB, Stevenson AT, Calaman S, Cole FS, Balmer DF, Hepps JH, Lopreiato JO, Yu CE, Sectish TC, Landrigan CP, I-PASS Study Group. Changes in medical errors after implementation of a handoff program. N Engl J Med. 2014;371(19):1803-12. doi:10.1056/NEJMsa1405556  PMID:25372088  
  8. Szafranski P, Dharmadhikari AV, Wambach JA, Towe CT, White FV, Grady RM, Eghtesady P, Cole FS, Deutsch G, Sen P, Stankiewicz P. Two deletions overlapping a distant FOXF1 enhancer unravel the role of lncRNA LINC01081 in etiology of alveolar capillary dysplasia with misalignment of pulmonary veins. Am J Med Genet A. 2014;164A(8):2013-9. doi:10.1002/ajmg.a.36606  PMCID:PMC4107046  PMID:24842713  
  9. Wambach JA, Casey AM, Fishman MP, Wegner DJ, Wert SE, Cole FS, Hamvas A, Nogee LM. Genotype-phenotype correlations for infants and children with ABCA3 deficiency. Am J Respir Crit Care Med. 2014;189(12):1538-43. doi:10.1164/rccm.201402-0342OC  PMCID:PMC4226019  PMID:24871971  
  10. Starmer AJ, O'Toole JK, Rosenbluth G, Calaman S, Balmer D, West DC, Bale JF Jr, Yu CE, Noble EL, Tse LL, Srivastava R, Landrigan CP, Sectish TC, Spector ND, I-PASS Study Education Executive Committee. Development, implementation, and dissemination of the I-PASS handoff curriculum: A multisite educational intervention to improve patient handoffs. Acad Med. 2014;89(6):876-84. doi:10.1097/ACM.0000000000000264  PMID:24871238  
  11. Wambach JA, Wegner DJ, Heins HB, Druley TE, Mitra RD, Hamvas A, Cole FS. Synonymous ABCA3 variants do not increase risk for neonatal respiratory distress syndrome. J Pediatr. 2014;164(6):1316-1321.e3. doi:10.1016/j.jpeds.2014.02.021  PMCID:PMC4035386  PMID:24657120  
  12. Ramos EI, Bien-Willner GA, Li J, Hughes AE, Giacalone J, Chasnoff S, Kulkarni S, Parmacek M, Cole FS, Druley TE. Genetic variation in MKL2 and decreased downstream PCTAIRE1 expression in extreme, fatal primary human microcephaly. Clin Genet. 2014;85(5):423-32. doi:10.1111/cge.12197  PMCID:PMC3929543  PMID:23692340  
  13. Coghlan MA, Shifren A, Huang HJ, Russell TD, Mitra RD, Zhang Q, Wegner DJ, Cole FS, Hamvas A. Sequencing of idiopathic pulmonary fibrosis-related genes reveals independent single gene associations. BMJ Open Respir Res. 2014;1(1):e000057. doi:10.1136/bmjresp-2014-000057  PMCID:PMC4265083  PMID:25553246  
  14. O'Toole JK, West DC, Starmer AJ, Yu CE, Calaman S, Rosenbluth G, Hepps JH, Lopreiato JO, Landrigan CP, Sectish TC, Spector ND, I-PASS Study Education Executive Committee. Placing faculty development front and center in a multisite educational initiative: lessons from the I-PASS Handoff study. Acad Pediatr. 2014;14(3):221-4. doi:10.1016/j.acap.2014.02.013  PMID:24767774  
  15. van Meel E, Wegner DJ, Cliften P, Willing MC, White FV, Kornfeld S, Cole FS. Rare recessive loss-of-function methionyl-tRNA synthetase mutations presenting as a multi-organ phenotype. BMC Med Genet. 2013;14(1):106. doi:10.1186/1471-2350-14-106  PMID:24103465  
  16. Hamvas A, Deterding RR, Wert SE, White FV, Dishop MK, Alfano DN, Halbower AC, Planer B, Stephan MJ, Uchida DA, Williames LD, Rosenfeld JA, Lebel RR, Young LR, Cole FS, Nogee LM. Heterogeneous pulmonary phenotypes associated with mutations in the thyroid transcription factor gene NKX2-1. Chest. 2013;144(3):794-804. doi:10.1378/chest.12-2502  PMCID:PMC3760742  PMID:23430038  
  17. Wilfond BS, Magnus D, Antommaria AH, Appelbaum P, Aschner J, Barrington KJ, Beauchamp T, Boss RD, Burke W, Caplan AL, Capron AM, Cho M, Clayton EW, Cole FS, Darlow BA, Diekema D, Faden RR, Feudtner C, Fins JJ, Fost NC, Frader J, Hester DM, Janvier A, Joffe S, Kahn J, Kass NE, Kodish E, Lantos JD, McCullough L, McKinney R Jr, Meadow W, O'Rourke PP, Powderly KE, Pursley DM, Ross LF, Sayeed S, Sharp RR, Sugarman J, Tarnow-Mordi WO, Taylor H, Tomlinson T, Truog RD, Unguru YT, Weise KL, Woodrum D, Youngner S. The OHRP and SUPPORT. N Engl J Med. 2013;368(25):e36. doi:10.1056/NEJMc1307008  PMID:23738513  
  18. Sen P, Yang Y, Navarro C, Silva I, Szafranski P, Kolodziejska KE, Dharmadhikari AV, Mostafa H, Kozakewich H, Kearney D, Cahill JB, Whitt M, Bilic M, Margraf L, Charles A, Goldblatt J, Gibson K, Lantz PE, Garvin AJ, Petty J, Kiblawi Z, Zuppan C, McConkie-Rosell A, McDonald MT, Peterson-Carmichael SL, Gaede JT, Shivanna B, Schady D, Friedlich PS, Hays SR, Palafoll IV, Siebers-Renelt U, Bohring A, Finn LS, Siebert JR, Galambos C, Nguyen L, Riley M, Chassaing N, Vigouroux A, Rocha G, Fernandes S, Brumbaugh J, Roberts K, Ho-Ming L, Lo IF, Lam S, Gerychova R, Jezova M, Valaskova I, Fellmann F, Afshar K, Giannoni E, Muhlethaler V, Liang J, Beckmann JS, Lioy J, Deshmukh H, Srinivasan L, Swarr DT, Sloman M, Shaw-Smith C, van Loon RL, Hagman C, Sznajer Y, Barrea C, Galant C, Detaille T, Wambach JA, Cole FS, Hamvas A, Prince LS, Diderich KE, Brooks AS, Verdijk RM, Ravindranathan H, Sugo E, Mowat D, Baker ML, Langston C, Welty S, Stankiewicz P. Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain. Hum Mutat. 2013;34(6):801-11. doi:10.1002/humu.22313  PMCID:PMC3663886  PMID:23505205  
  19. Anderson JL, Levy PT, Leonard KB, Smyser CD, Tychsen L, Cole FS. Congenital lymphocytic choriomeningitis virus: when to consider the diagnosis. J Child Neurol. 2013;29(6):837-842. doi:10.1177/0883073813486295  PMCID:PMC3972356  PMID:23666045  
  20. Mills KI, Anderson J, Levy PT, Cole FS, Silva JN, Kulkarni S, Shinawi M. Duplication of 20p12.3 associated with familial Wolff-Parkinson-White syndrome. Am J Med Genet A. 2013;161A(1):137-44. doi:10.1002/ajmg.a.35701  PMID:23239491  
  21. Wambach JA, Wegner DJ, Depass K, Heins H, Druley TE, Mitra RD, An P, Zhang Q, Nogee LM, Cole FS, Hamvas A. Single ABCA3 mutations increase risk for neonatal respiratory distress syndrome. Pediatrics. 2012;130(6):e1575-82. doi:10.1542/peds.2012-0918  PMCID:PMC3507255  PMID:23166334  
  22. Anadkat JS, Kuzniewicz MW, Chaudhari BP, Cole FS, Hamvas A. Increased risk for respiratory distress among white, male, late preterm and term infants. J Perinatol. 2012;32(10):780-5. doi:10.1038/jp.2011.191  PMCID:PMC3461404  PMID:22222548  
  23. Agrawal A, Hamvas A, Cole FS, Wambach JA, Wegner D, Coghill C, Harrison K, Nogee LM. An intronic ABCA3 mutation that is responsible for respiratory disease. Pediatr Res. 2012;71(6):633-7. doi:10.1038/pr.2012.21  PMID:22337229  
  24. Bereman MS, Tomazela DM, Heins HS, Simonato M, Cogo PE, Hamvas A, Patterson BW, Cole FS, MacCoss MJ. A method to determine the kinetics of multiple proteins in human infants with respiratory distress syndrome. Anal Bioanal Chem. 2012;403(8):2397-402. doi:10.1007/s00216-012-5953-3  PMID:22526637  
  25. Starmer AJ, Spector ND, Srivastava R, Allen AD, Landrigan CP, Sectish TC, I-PASS Study Group. I-pass, a mnemonic to standardize verbal handoffs. Pediatrics. 2012;129(2):201-4. doi:10.1542/peds.2011-2966  PMID:22232313  
  26. Sectish TC, Starmer AJ, Landrigan CP, Spector ND, I-PASS Study Group. Establishing a multisite education and research project requires leadership, expertise, collaboration, and an important aim. Pediatrics. 2010;126(4):619-22. doi:10.1542/peds.2010-1793  PMID:20876168  
  27. Wambach JA, Yang P, Wegner DJ, An P, Hackett BP, Cole FS, Hamvas A. Surfactant protein-C promoter variants associated with neonatal respiratory distress syndrome reduce transcription. Pediatr Res. 2010;68(3):216-20. doi:10.1203/PDR.0b013e3181eb5d68  PMCID:PMC2921462  PMID:20539253  
  28. Tomazela DM, Patterson BW, Hanson E, Spence KL, Kanion TB, Salinger DH, Vicini P, Barret H, Heins HB, Cole FS, Hamvas A, MacCoss MJ. Measurement of human surfactant protein-B turnover in vivo from tracheal aspirates using targeted proteomics. Anal Chem. 2010;82(6):2561-7. doi:10.1021/ac1001433  PMCID:PMC2843406  PMID:20178338  
  29. Hamvas A, Nogee LM, Wegner DJ, Depass K, Christodoulou J, Bennetts B, McQuade LR, Gray PH, Deterding RR, Carroll TR, Kammesheidt A, Kasch LM, Kulkarni S, Cole FS. Inherited surfactant deficiency caused by uniparental disomy of rare mutations in the surfactant protein-B and ATP binding cassette, subfamily a, member 3 genes. J Pediatr. 2009;155(6):854-859.e1. doi:10.1016/j.jpeds.2009.06.006  PMCID:PMC2794197  PMID:19647838  
  30. Druley TE, Vallania FL, Wegner DJ, Varley KE, Knowles OL, Bonds JA, Robison SW, Doniger SW, Hamvas A, Cole FS, Fay JC, Mitra RD. Quantification of rare allelic variants from pooled genomic DNA. Nat Methods. 2009;6(4):263-5. doi:10.1038/nmeth.1307  PMCID:PMC2776647  PMID:19252504  
  31. Hamvas A, Heins HB, Guttentag SH, Wegner DJ, Trusgnich MA, Bennet KW, Yang P, Carlson CS, An P, Cole FS. Developmental and genetic regulation of human surfactant protein B in vivo. Neonatology. 2009;95(2):117-24. doi:10.1159/000153095  PMCID:PMC2765709  PMID:18776725  
  32. Garmany TH, Wambach JA, Heins HB, Watkins-Torry JM, Wegner DJ, Bennet K, An P, Land G, Saugstad OD, Henderson H, Nogee LM, Cole FS, Hamvas A. Population and disease-based prevalence of the common mutations associated with surfactant deficiency. Pediatr Res. 2008;63(6):645-9. doi:10.1203/PDR.0b013e31816fdbeb  PMCID:PMC2765719  PMID:18317237  
  33. McBee AD, Wegner DJ, Carlson CS, Wambach JA, Yang P, Heins HB, Saugstad OD, Trusgnich MA, Watkins-Torry J, Nogee LM, Henderson H, Cole FS, Hamvas A. Recombination as a mechanism for sporadic mutation in the surfactant protein-C gene. Pediatr Pulmonol. 2008;43(5):443-50. doi:10.1002/ppul.20782  PMCID:PMC2765708  PMID:18383112  
  34. Hamvas A, Wegner DJ, Carlson CS, Bergmann KR, Trusgnich MA, Fulton L, Kasai Y, An P, Mardis ER, Wilson RK, Cole FS. Comprehensive genetic variant discovery in the surfactant protein B gene. Pediatr Res. 2007;62(2):170-5. doi:10.1203/PDR.0b013e3180a03232  PMCID:PMC2765713  PMID:17597650  
  35. Wegner DJ, Hertzberg T, Heins HB, Elmberger G, MacCoss MJ, Carlson CS, Nogee LM, Cole FS, Hamvas A. A major deletion in the surfactant protein-B gene causing lethal respiratory distress. Acta Paediatr. 2007;96(4):516-20. doi:10.1111/j.1651-2227.2006.00188.x  PMID:17391469  
  36. Saugstad OD, Hansen TW, Rønnestad A, Nakstad B, Tølløfsrud PA, Reinholt F, Hamvas A, Coles FS, Dean M, Wert SE, Whitsett JA, Nogee LM. Novel mutations in the gene encoding ATP binding cassette protein member A3 (ABCA3) resulting in fatal neonatal lung disease. Acta Paediatr. 2007;96(2):185-90. PMID:17429902  
  37. Kistka ZA, Palomar L, Lee KA, Boslaugh SE, Wangler MF, Cole FS, DeBaun MR, Muglia LJ. Racial disparity in the frequency of recurrence of preterm birth. Am J Obstet Gynecol. 2007;196(2):131.e1-6. doi:10.1016/j.ajog.2006.06.093  PMID:17306652  
  38. Hamvas A, Cole FS, Nogee LM. Genetic disorders of surfactant proteins. Neonatology. 2007;91(4):311-7. doi:10.1159/000101347  PMID:17575475  
  39. Palomar LM, Nogee LM, Sweet SC, Huddleston CB, Cole FS, Hamvas A. Long-term outcomes after infant lung transplantation for surfactant protein B deficiency related to other causes of respiratory failure. J Pediatr. 2006;149(4):548-53. doi:10.1016/j.jpeds.2006.06.004  PMID:17011330  
  40. Cole FS, Nogee LM, Hamvas A. Defects in surfactant synthesis: clinical implications. Pediatr Clin North Am. 2006;53(5):911-27, ix. doi:10.1016/j.pcl.2006.08.006  PMID:17027617  
  41. Hamvas A, Wegner DJ, Trusgnich MA, Madden K, Heins H, Liu Y, Rice T, An P, Watkins-Torry J, Cole FS. Genetic variant characterization in intron 4 of the surfactant protein B gene. Hum Mutat. 2005;26(5):494-5. doi:10.1002/humu.9378  PMID:16211553  
  42. Hamvas A, Madden KK, Nogee LM, Trusgnich MA, Wegner DJ, Heins HB, Cole FS. Informed consent for genetic research. Arch Pediatr Adolesc Med. 2004;158(6):551-5. doi:10.1001/archpedi.158.6.551  PMID:15184218  
  43. Cole FS. Surfactant protein B: unambiguously necessary for adult pulmonary function. Am J Physiol Lung Cell Mol Physiol. 2003;285(3):L540-2. doi:10.1152/ajplung.00111.2003  PMID:12902317  
  44. Wilson RK, Ley TJ, Cole FS, Milbrandt JD, Clifton S, Fulton L, Fewell G, Minx P, Sun H, McLellan M, Pohl C, Mardis ER. Mutational profiling in the human genome. Cold Spring Harb Symp Quant Biol. 2003;68:23-9. PMID:15338599  
  45. Hamvas A, Trusgnich M, Brice H, Baumgartner J, Hong Y, Nogee LM, Cole FS. Population-based screening for rare mutations: high-throughput DNA extraction and molecular amplification from Guthrie cards. Pediatr Res. 2001;50(5):666-8. doi:10.1203/00006450-200111000-00021  PMID:11641464  
  46. Cole FS, Hamvas A, Nogee LM. Genetic disorders of neonatal respiratory function. Pediatr Res. 2001;50(2):157-62. doi:10.1203/00006450-200108000-00001  PMID:11477198  
  47. Merchak A, Lueder GT, White FV, Cole FS. Alveolar capillary dysplasia with misalignment of pulmonary veins and anterior segment dysgenesis of the eye: a report of a new association and review of the literature. J Perinatol. 2001;21(5):327-30. doi:10.1038/sj.jp.7200494  PMID:11536028  
  48. Cole FS, Hamvas A, Rubinstein P, King E, Trusgnich M, Nogee LM, deMello DE, Colten HR. Population-based estimates of surfactant protein B deficiency. Pediatrics. 2000;105(3 Pt 1):538-41. PMID:10699106  
  49. Hamvas A, Kwong P, DeBaun M, Schramm W, Cole FS. Hyaline membrane disease is underreported in a linked birth-infant death certificate database. Am J Public Health. 1998;88(9):1387-9. PMCID:PMC1509088  PMID:9736884  
  50. Chen B, Basil JB, Schefft GL, Cole FS, Sadovsky Y. Antenatal steroids and intraventricular hemorrhage after premature rupture of membranes at 24-28 weeks' gestation. Am J Perinatol. 1997;14(3):171-6. doi:10.1055/s-2007-994121  PMID:9259922  
  51. Kempe A, Wise PH, Wampler NS, Cole FS, Wallace H, Dickinson C, Rinehart H, Lezotte DC, Beaty B. Risk status at discharge and cause of death for postneonatal infant deaths: a total population study. Pediatrics. 1997;99(3):338-44. PMID:9041284  
  52. Hamvas A, Nogee LM, Mallory GB Jr, Spray TL, Huddleston CB, August A, Dehner LP, deMello DE, Moxley M, Nelson R, Cole FS, Colten HR. Lung transplantation for treatment of infants with surfactant protein B deficiency. J Pediatr. 1997;130(2):231-9. PMID:9042125  
  53. Hamvas A, Wise PH, Yang RK, Wampler NS, Noguchi A, Maurer MM, Walentik CA, Schramm WF, Cole FS. The influence of the wider use of surfactant therapy on neonatal mortality among blacks and whites. N Engl J Med. 1996;334(25):1635-40. doi:10.1056/NEJM199606203342504  PMID:8628359  
  54. Kilani RA, Cole FS, Bier DM. Phenylalanine hydroxylase activity in preterm infants: is tyrosine a conditionally essential amino acid? Am J Clin Nutr. 1995;61(6):1218-23. PMID:7762520  
  55. Sunwood J, Brenman A, Escobedo J, Philpott T, Allman K, Mueller J, Jaeger J, Brown LK, Cole FS. School-based AIDS education for adolescents. J Adolesc Health. 1995;16(4):309-15. PMID:7612637  
  56. Hamvas A, Nogee LM, deMello DE, Cole FS. Pathophysiology and treatment of surfactant protein-B deficiency. Biol Neonate. 1995;67 Suppl 1:18-31. PMID:7647155  
  57. Khurana A, Huettner PC, Cole FS. Umbilical cord ulceration as a cause of hypoxic-ischemic encephalopathy: report of a case and review of the literature. J Perinatol. 1995;15(5):423-5. PMID:8576764  
  58. DeBaun M, Rowley D, Province M, Stockbauer JW, Cole FS. Selected antepartum medical complications and very-low-birthweight infants among black and white women. Am J Public Health. 1994;84(9):1495-7. PMCID:PMC1615154  PMID:8092380  
  59. Hamvas A, Cole FS, deMello DE, Moxley M, Whitsett JA, Colten HR, Nogee LM. Surfactant protein B deficiency: antenatal diagnosis and prospective treatment with surfactant replacement. J Pediatr. 1994;125(3):356-61. PMID:8071741  
  60. deMello DE, Heyman S, Phelps DS, Hamvas A, Nogee L, Cole S, Colten HR. Ultrastructure of lung in surfactant protein B deficiency. Am J Respir Cell Mol Biol. 1994;11(2):230-9. doi:10.1165/ajrcmb.11.2.8049084  PMID:8049084  
  61. Strunk RC, Fleischer JA, Katz Y, Cole FS. Developmentally regulated effects of lipopolysaccharide on biosynthesis of the third component of complement and factor B in human fibroblasts and monocytes. Immunology. 1994;82(2):314-20. PMCID:PMC1414817  PMID:7927503  
  62. Hamvas A, Devine T, Cole FS. Surfactant therapy failure identifies infants at risk for pulmonary mortality. Am J Dis Child. 1993;147(6):665-8. PMID:8506837  
  63. Coffin CM, Schechtman K, Cole FS, Dehner LP. Neonatal and infantile pulmonary hemorrhage: an autopsy study with clinical correlation. Pediatr Pathol. 1993;13(5):583-9. PMID:8247956  
  64. Fjeld CR, Cole FS, Bier DM. Energy expenditure, lipolysis, and glucose production in preterm infants treated with theophylline. Pediatr Res. 1992;32(6):693-8. doi:10.1203/00006450-199212000-00015  PMID:1287561  
  65. Kempe A, Wise PH, Barkan SE, Sappenfield WM, Sachs B, Gortmaker SL, Sobol AM, First LR, Pursley D, Rinehart H. Clinical determinants of the racial disparity in very low birth weight. N Engl J Med. 1992;327(14):969-73. doi:10.1056/NEJM199210013271401  PMID:1518548  
  66. Johnson CA, Densen P, Wetsel RA, Cole FS, Goeken NE, Colten HR. Molecular heterogeneity of C2 deficiency. N Engl J Med. 1992;326(13):871-4. doi:10.1056/NEJM199203263261306  PMID:1542325  
  67. Porter FL, Miller JP, Cole FS, Marshall RE. A controlled clinical trial of local anesthesia for lumbar punctures in newborns. Pediatrics. 1991;88(4):663-9. PMID:1896268  
  68. Lennartz MR, Cole FS, Stahl PD. Biosynthesis and processing of the mannose receptor in human macrophages. J Biol Chem. 1989;264(4):2385-90. PMID:2914913  
  69. Whyte MP, Mahuren JD, Fedde KN, Cole FS, McCabe ER, Coburn SP. Perinatal hypophosphatasia: tissue levels of vitamin B6 are unremarkable despite markedly increased circulating concentrations of pyridoxal-5'-phosphate. Evidence for an ectoenzyme role for tissue-nonspecific alkaline phosphatase. J Clin Invest. 1988;81(4):1234-9. doi:10.1172/JCI113440  PMCID:PMC329654  PMID:3350970  
  70. Katz Y, Cole FS, Strunk RC. Synergism between gamma interferon and lipopolysaccharide for synthesis of factor B, but not C2, in human fibroblasts. J Exp Med. 1988;167(1):1-14. PMCID:PMC2188816  PMID:3121777  
  71. Lennartz MR, Cole FS, Shepherd VL, Wileman TE, Stahl PD. Isolation and characterization of a mannose-specific endocytosis receptor from human placenta. J Biol Chem. 1987;262(21):9942-4. PMID:3611070  
  72. Perlmutter DH, Strunk RC, Goldberger G, Cole FS. Regulation of complement proteins C2 and factor B by interleukin-1 and interferon-gamma acting on transfected L cells. Mol Immunol. 1986;23(11):1263-6. PMID:3029573  
  73. Royer-Pokora B, Kunkel LM, Monaco AP, Goff SC, Newburger PE, Baehner RL, Cole FS, Curnutte JT, Orkin SH. Cloning the gene for an inherited human disorder--chronic granulomatous disease--on the basis of its chromosomal location. Nature. 1986;322:32-8. doi:10.1038/322032a0  PMID:2425263  
  74. Sutton MB, Strunk RC, Cole FS. Regulation of the synthesis of the third component of complement and factor B in cord blood monocytes by lipopolysaccharide. J Immunol. 1986;136(4):1366-72. PMID:3003195  
  75. Royer-Pokora B, Kunkel LM, Monaco AP, Goff SC, Newburger PE, Baehner RL, Cole FS, Curnutte JT, Orkin SH. Cloning the gene for the inherited disorder chronic granulomatous disease on the basis of its chromosomal location. Cold Spring Harb Symp Quant Biol. 1986;51 Pt 1:177-83. PMID:3472714  
  76. Strunk RC, Cole FS, Perlmutter DH, Colten HR. gamma-Interferon increases expression of class III complement genes C2 and factor B in human monocytes and in murine fibroblasts transfected with human C2 and factor B genes. J Biol Chem. 1985;260(28):15280-5. PMID:2866182  
  77. Zannis VI, Ordovas JM, Cladaras C, Cole FS, Forbes G, Schaefer EJ. mRNA and apolipoprotein E synthesis abnormalities in peripheral blood monocyte macrophages in familial apolipoprotein E deficiency. J Biol Chem. 1985;260(24):12891-4. PMID:2997147  
  78. Perlmutter DH, Kay RM, Cole FS, Rossing TH, Van Thiel D, Colten HR. The cellular defect in alpha 1-proteinase inhibitor (alpha 1-PI) deficiency is expressed in human monocytes and in Xenopus oocytes injected with human liver mRNA. Proc Natl Acad Sci U S A. 1985;82(20):6918-21. PMCID:PMC390799  PMID:3876562  
  79. Strunk RC, Whitehead AS, Cole FS. Pretranslational regulation of the synthesis of the third component of complement in human mononuclear phagocytes by the lipid A portion of lipopolysaccharide. J Clin Invest. 1985;76(3):985-90. doi:10.1172/JCI112099  PMCID:PMC423963  PMID:3900137  
  80. Zannis VI, Cole FS, Jackson CL, Kurnit DM, Karathanasis SK. Distribution of apolipoprotein A-I, C-II, C-III, and E mRNA in fetal human tissues. Time-dependent induction of apolipoprotein E mRNA by cultures of human monocyte-macrophages. Biochemistry. 1985;24(16):4450-5. PMID:3931677  
  81. Cole FS, Whitehead AS, Auerbach HS, Lint T, Zeitz HJ, Kilbridge P, Colten HR. The molecular basis for genetic deficiency of the second component of human complement. N Engl J Med. 1985;313(1):11-6. doi:10.1056/NEJM198507043130103  PMID:2582254  
  82. Pennington JE, Cole FS, Boerth LW. Intrapulmonary chemotaxins in the normal and in the cyclophosphamide-treated host. Am Rev Respir Dis. 1985;131(6):845-9. doi:10.1164/arrd.1985.131.6.845  PMID:4003935  
  83. Cole FS, Auerbach HS, Goldberger G, Colten HR. Tissue-specific pretranslational regulation of complement production in human mononuclear phagocytes. J Immunol. 1985;134(4):2610-6. PMID:3844437  
  84. Perlmutter DH, Cole FS, Kilbridge P, Rossing TH, Colten HR. Expression of the alpha 1-proteinase inhibitor gene in human monocytes and macrophages. Proc Natl Acad Sci U S A. 1985;82(3):795-9. PMCID:PMC397133  PMID:3871944  
  85. Perlmutter DH, Kay RM, Cole FS, Rossing TH, Van Thiel D, Colten HR. A selective defect in secretion of alpha 1-proteinase inhibitor PiZZ demonstrated in surrogate and primary extrahepatic cell culture. Trans Assoc Am Physicians. 1985;98:47-54. PMID:3879845  
  86. Perlmutter DH, Cole FS, Goldberger G, Colten HR. Distinct primary translation products from human liver mRNA give rise to secreted and cell-associated forms of complement protein C2. J Biol Chem. 1984;259(16):10380-5. PMID:6088497  
  87. Yin HL, Kwiatkowski DJ, Mole JE, Cole FS. Structure and biosynthesis of cytoplasmic and secreted variants of gelsolin. J Biol Chem. 1984;259(8):5271-6. PMID:6325429  
  88. Key L, Carnes D, Cole S, Holtrop M, Bar-Shavit Z, Shapiro F, Arceci R, Steinberg J, Gundberg C, Kahn A. Treatment of congenital osteopetrosis with high-dose calcitriol. N Engl J Med. 1984;310(7):409-15. doi:10.1056/NEJM198402163100701  PMID:6546410  
  89. DiPietro MA, Brody BA, Kuban K, Cole FS. Schizencephaly: rare cerebral malformation demonstrated by sonography. AJNR Am J Neuroradiol. 1984;5(2):196-8. PMID:6422720  
  90. Winter HS, Cole FS, Huffer LM, Davidson CB, Katz AJ, Edelson PJ. Isolation and characterization of resident macrophages from guinea pig and human intestine. Gastroenterology. 1983;85(2):358-63. PMID:6190701  
  91. Cole FS, Matthews WJ Jr, Rossing TH, Gash DJ, Lichtenberg NA, Pennington JE. Complement biosynthesis by human bronchoalveolar macrophages. Clin Immunol Immunopathol. 1983;27(2):153-9. PMID:6553519  
  92. Alpert SE, Auerbach HS, Cole FS, Colten HR. Macrophage maturation: differences in complement secretion by marrow, monocyte, and tissue macrophages detected with an improved hemolytic plaque assay. J Immunol. 1983;130(1):102-7. PMID:6336622  
  93. Goldberger G, Cole FS, Einstein LP, Auerbach HS, Bitter-Suermann D, Colten HR. Biosynthesis of a structurally abnormal C2 complement protein by macrophages from C2-deficient guinea pigs. J Immunol. 1982;129(5):2061-5. PMID:6922142  
  94. Cole FS, Schneeberger EE, Lichtenberg NA, Colten HR. Complement biosynthesis in human breast-milk macrophages and blood monocytes. Immunology. 1982;46(2):429-41. PMCID:PMC1555385  PMID:6919505  
  95. Cole FS, Saryan JA, Smith AL. The risk of additional systemic bacterial illness in infants with systemic Streptococcus pneumoniae disease. J Pediatr. 1981;99(1):91-4. PMID:7252672  
  96. Beatty DW, Davis AE 3rd, Cole FS, Einstein LP, Colten HR. Biosynthesis of complement by human monocytes. Clin Immunol Immunopathol. 1981;18(3):334-43. PMID:6910430  
  97. Cole FS, Matthews WJ Jr, Marino JT, Gash DJ, Colten HR. Control of complement synthesis and secretion in bronchoalveolar and peritoneal macrophages. J Immunol. 1980;125(3):1120-4. PMID:6997377  
  98. Cole FS, Brusch JL, Talarico L. A circulating anticoagulant in lepromatous leprosy. Int J Lepr Other Mycobact Dis. 1979;47(2):121-5. PMID:378869  
  99. Cole FS, Daum RS, Teller L, Goldmann DA, Smith AL. Effect of ampicillin and chloramphenicol alone and in combination on ampicillin-susceptible and -resistant Haemophilus influenzae type B. Antimicrob Agents Chemother. 1979;15(3):415-9. PMCID:PMC352675  PMID:313752  
  100. Schwartz AL, Cole FS, Fiedorek F, Matthews D, Paika I, Frantz ID, Latt SA. Effect of phototherapy on sister chromatid exchange in premature infants. Lancet. 1978;2(8081):157-8. PMID:78359  
  101. Cole FS, Todres ID, Shannon DC. Technique for percutaneous cannulation of the radial artery in the newborn infant. J Pediatr. 1978;92(1):105-7. PMID:619050  
  102. Askinazi C, Cole FS, Brusch JL. Positive differential heterophile antibody test. Persistence in a symptomatic patient. JAMA. 1976;236(13):1492-3. PMID:183027  
  103. Cole FS. A study of neonatal hyperbilirubinemia: The role of the enterohepatic circulation of bilirubin. A thesis submitted in partial fulfillment of the requirements for the degree of Doctor of Medicine to the Departments of Medicine and Pediatrics Yale University School of Medicine, New Haven, Connecticut. 1973. 
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