Mary C. Dinauer, M.D., Ph.D.  dinauer_m@kids.wustl.edu

Fred M. Saigh Distinguished Chair in Pediatric Research, Washington University School of Medicine
Professor, Department of Pediatrics
Professor, Pathology & Immunology
Scientific Director, Children's Discovery Institute, Washington University School of Medicine
Pathology & ImmunologyDevelopmental BiologyPediatrics

phone: (314) 454-6005

Clinical Interests

Research interests: Dr. Dinauer studies the superoxide-generating leukocyte NADPH oxidase and the role of oxidant production by neutrophils and macrophages in microbial killing, the inflammatory response, and autoimmunity. Inactivating mutations in the NADPH oxidase result in chronic granulomatous disease (CGD), a primary immunodeficiency associated with recurrent bacterial and fungal infections as well as a variety of chronic inflammatory disorders, including inflammatory bowel disease and discoid lupus. Moreover, hypomorphic NADPH oxidase gene variants are now linked to inflammatory bowel disease and autoimmunity. These clinical manifestations reflect the dual importance of the NADPH oxidase both for microbial killing and for negatively regulating cellular processes that limit inflammation by redox mechanisms.

Education

  • B.A., Lawrence University1975
  • Ph.D., University of Chicago1979
  • M.D., University of Chicago1981

Training

  • Internship and Residency in Pediatrics, University of California1981 - 1984
  • Chief Residency in Pediatrics, University of California1984 - 1985
  • Fellowship in Pediatric Hematology/Oncology, Children’s Hospital and Dana-Farber Cancer Institute, Harvard Medical School1985 - 1988

Licensure and Board Certification

  • National Board of Medical Examiners1982
  • CA, California License 1983
  • MA, Massachusetts License 1986
  • American Board of Pediatrics1986
  • IN, Indiana License1991
  • MO, Missouri License2012

Honors

  • Phi Beta Kappa1974
  • Summa Cum Laude, Lawrence University1975
  • Medical Scientist Training Program1975 - 1981
  • Alpha Omega Alpha1981
  • American Medical Women's Association Award, University of Chicago1981
  • Mary Roberts Scott Memorial Prize, University of Chicago1981
  • Medical Doctorate, with Honors, University of Chicago1981
  • Basil O'Connor Starter Scholar Research Award, March of Dimes1990 - 1992
  • JV Satterfield Arthritis Investigator, Arthritis Foundation1990 - 1993
  • American Society of Clinical Investigation1995
  • Excellence in Pediatrics Research Award, American Academy of Pediatrics1995
  • Soroptimist International of Indianapolis, Woman of Distinction Honoree1996
  • Lucia R. Briggs Distinguished Achievement Award, Lawrence University2000
  • Association of American Physicians2008
  • Fellow, American Association for the Advancement of Science2014

Recent Publications view all (163)


Publication Co-Authors

  1. Bagaitkar J, Barbu EA, Perez-Zapata LJ, Austin A, Huang G, Pallat S, Dinauer MC. PI(3)P-p40phox binding regulates NADPH oxidase activation in mouse macrophages and magnitude of inflammatory responses in vivo. J Leuko Biol. 2016. doi:http://dx.doi.org/10.1189/jlb.3AB0316-139R  PMID:27543673  
  2. Lu Q, Yokoyama CC, Williams JW, Baldridge MT, Jin X, DesRochers B, Bricker T, Wilen CB, Bagaitkar J, Loginicheva E, Sergushichev A, Kreamalmeyer D, Keller BC, Zhao Y, Kambal A, Green DR, Martinez J, Dinauer MC, Holtzman MJ, Crouch EC, Beatty W, Boon AC, Zhang H, Randolph GJ, Artyomov MN, Virgin HW. Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis. Cell Host Microbe. 2016;19(1):102-13. PMCID:PMC4714358  PMID:26764600  
  3. Bagaitkar J, Pech NK, Ivanov S, Austin A, Zeng MY, Huang G, Randolph GJ, Dinauer MC. NADPH oxidase controls neutrophilic response to sterile inflammation in mice by regulating the IL-1α/G-CSF axis. Blood. 2015;17(126(25)):2724-33. doi:10.1182/blood-2015-05-644773  PMID:26443623  
  4. McLetchie S, Volpp BD, Dinauer MC, Blum JS. Hyper-responsive Toll-like receptor 7 and 9 activation in NADPH oxidase-deficient B lymphoblasts. Immunology. 2015;146(4):595-606. doi:10.1111/imm.12530  PMCID:4693894  PMID:26340429  
  5. Gomez JC, Yamada M, Martin JR, Dang H, Brickey WJ, Bergmeier W, Dinauer MC, Doerschuk CM. Mechanisms of interferon-γ production by neutrophils and its function during Streptococcus pneumoniae pneumonia. Am J Respir Cell Mol Biol. 2015;52(3):349-64. doi:10.1165/rcmb.2013-0316OC  PMCID:PMC4370257  PMID:25100610  
  6. Roos D, van Buul JD, Tool AT, Matute JD, Marchal CM, Hayee B, Köker MY, de Boer M, van Leeuwen K, Segal AW, Pick E, Dinauer MC. Two CGD Families with a Hypomorphic Mutation in the Activation Domain of p67phox. J Clin Cell Immunol. 2014;5(3). PMCID:PMC4414043  PMID:25937994  
  7. Chaturvedi KS, Hung CS, Giblin DE, Urushidani S, Austin AM, Dinauer MC, Henderson JP. Cupric yersiniabactin is a virulence-associated superoxide dismutase mimic. ACS Chem Biol. 2014;9(2):551-61. doi:10.1021/cb400658k  PMCID:PMC3934373  PMID:24283977  
  8. Griffith LM, Cowan MJ, Notarangelo LD, Kohn DB, Puck JM, Pai SY, Ballard B, Bauer SC, Bleesing JJ, Boyle M, Brower A, Buckley RH, van der Burg M, Burroughs LM, Candotti F, Cant AJ, Chatila T, Cunningham-Rundles C, Dinauer MC, Dvorak CC, Filipovich AH, Fleisher TA, Bobby Gaspar H, Gungor T, Haddad E, Hovermale E, Huang F, Hurley A, Hurley M, Iyengar S, Kang EM, Logan BR, Long-Boyle JR, Malech HL, McGhee SA, Modell F, Modell V, Ochs HD, O'Reilly RJ, Parkman R, Rawlings DJ, Routes JM, Shearer WT, Small TN, Smith H, Sullivan KE, Szabolcs P, Thrasher A, Torgerson TR, Veys P, Weinberg K, Zuniga-Pflucker JC, workshop participants. Primary Immune Deficiency Treatment Consortium (PIDTC) report. J Allergy Clin Immunol. 2014;133(2):335-47. doi:10.1016/j.jaci.2013.07.052  PMCID:PMC3960312  PMID:24139498  
  9. Patel KK, Miyoshi H, Beatty WL, Head RD, Malvin NP, Cadwell K, Guan JL, Saitoh T, Akira S, Seglen PO, Dinauer MC, Virgin HW, Stappenbeck TS. Autophagy proteins control goblet cell function by potentiating reactive oxygen species production. EMBO J. 2013;32(24):3130-44. doi:10.1038/emboj.2013.233  PMCID:PMC3981139  PMID:24185898  
  10. Nunes P, Demaurex N, Dinauer MC. Regulation of the NADPH oxidase and associated ion fluxes during phagocytosis. Traffic. 2013;14(11):1118-1131. doi:10.1111/tra.12115  PMID:23980663  
  11. Stein S, Scholz S, Schwäble J, Sadat MA, Modlich U, Schultze-Strasser S, Diaz M, Chen-Wichmann L, Müller-Kuller U, Brendel C, Fronza R, Kaufmann KB, Naundorf S, Pech NK, Travers JB, Matute JD, Presson RG Jr, Sandusky GE, Kunkel H, Rudolf E, Dillmann A, von Kalle C, Kühlcke K, Baum C, Schambach A, Dinauer MC, Schmidt M, Grez M. From bench to bedside: preclinical evaluation of a self-inactivating gammaretroviral vector for the gene therapy of X-linked chronic granulomatous disease. Hum Gene Ther Clin Dev. 2013;24(2):86-98. doi:10.1089/humc.2013.019  PMID:23845071  
  12. Zeng MY, Pham D, Bagaitkar J, Liu J, Otero K, Shan M, Wynn TA, Brombacher F, Brutkiewicz RR, Kaplan MH, Dinauer MC. An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD. Blood. 2013;121(17):3473-83. doi:10.1182/blood-2012-10-461913  PMCID:PMC3637016  PMID:23426944  
  13. Bagaitkar J, Matute JD, Austin A, Arias AA, Dinauer MC. Activation of neutrophil respiratory burst by fungal particles requires phosphatidylinositol 3-phosphate binding to p40(phox) in humans but not in mice. Blood. 2012;120(16):3385-7. doi:10.1182/blood-2012-07-445619  PMID:23086626  
  14. Crotzer VL, Matute JD, Arias AA, Zhao H, Quilliam LA, Dinauer MC, Blum JS. Cutting edge: NADPH oxidase modulates MHC class II antigen presentation by B cells. J Immunol. 2012;189(8):3800-4. doi:10.4049/jimmunol.1103080  PMCID:PMC3466399  PMID:22984083  
  15. Casbon AJ, Long ME, Dunn KW, Allen LA, Dinauer MC. Effects of IFN-γ on intracellular trafficking and activity of macrophage NADPH oxidase flavocytochrome b558. J Leukoc Biol. 2012;92(4):869-82. doi:10.1189/jlb.0512244  PMCID:PMC3441311  PMID:22822009  
  16. Jacob CO, Eisenstein M, Dinauer MC, Ming W, Liu Q, John S, Quismorio FP Jr, Reiff A, Myones BL, Kaufman KM, McCurdy D, Harley JB, Silverman E, Kimberly RP, Vyse TJ, Gaffney PM, Moser KL, Klein-Gitelman M, Wagner-Weiner L, Langefeld CD, Armstrong DL, Zidovetzki R. Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase. Proc Natl Acad Sci U S A. 2012;109(2):E59-67. doi:10.1073/pnas.1113251108  PMCID:PMC3258621  PMID:22203994  
  17. Mahankali M, Peng HJ, Henkels KM, Dinauer MC, Gomez-Cambronero J. Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2. Proc Natl Acad Sci U S A. 2011;108(49):19617-22. doi:10.1073/pnas.1114692108  PMCID:PMC3241757  PMID:22106281  
  18. Peng HJ, Henkels KM, Mahankali M, Marchal C, Bubulya P, Dinauer MC, Gomez-Cambronero J. The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxis. Mol Cell Biol. 2011;31(11):2227-40. doi:10.1128/MCB.01348-10  PMCID:PMC3133238  PMID:21444720  
  19. Yamada M, Gomez JC, Chugh PE, Lowell CA, Dinauer MC, Dittmer DP, Doerschuk CM. Interferon-γ production by neutrophils during bacterial pneumonia in mice. Am J Respir Crit Care Med. 2011;183(10):1391-401. doi:10.1164/rccm.201004-0592OC  PMCID:PMC3114063  PMID:21169470  
  20. Peng HJ, Henkels KM, Mahankali M, Dinauer MC, Gomez-Cambronero J. Evidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2. J Biol Chem. 2011;286(18):16308-20. doi:10.1074/jbc.M110.206672  PMCID:PMC3091237  PMID:21378159  
  21. Bustamante J, Arias AA, Vogt G, Picard C, Galicia LB, Prando C, Grant AV, Marchal CC, Hubeau M, Chapgier A, de Beaucoudrey L, Puel A, Feinberg J, Valinetz E, Jannière L, Besse C, Boland A, Brisseau JM, Blanche S, Lortholary O, Fieschi C, Emile JF, Boisson-Dupuis S, Al-Muhsen S, Woda B, Newburger PE, Condino-Neto A, Dinauer MC, Abel L, Casanova JL. Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease. Nat Immunol. 2011;12(3):213-21. doi:10.1038/ni.1992  PMCID:PMC3097900  PMID:21278736  
  22. Hawkins TB, Dantzer J, Peters B, Dinauer M, Mockaitis K, Mooney S, Cornetta K. Identifying viral integration sites using SeqMap 2.0. Bioinformatics. 2011;27(5):720-2. doi:10.1093/bioinformatics/btq722  PMCID:PMC3042184  PMID:21245052  
  23. Grez M, Reichenbach J, Schwäble J, Seger R, Dinauer MC, Thrasher AJ. Gene therapy of chronic granulomatous disease: the engraftment dilemma. Mol Ther. 2011;19(1):28-35. doi:10.1038/mt.2010.232  PMCID:PMC3017455  PMID:21045810  
  24. Xue X, Pech NK, Shelley WC, Srour EF, Yoder MC, Dinauer MC. Antibody targeting KIT as pretransplantation conditioning in immunocompetent mice. Blood. 2010;116(24):5419-22. doi:10.1182/blood-2010-07-295949  PMCID:PMC3012550  PMID:20813896  
  25. Li XJ, Marchal CC, Stull ND, Stahelin RV, Dinauer MC. p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation. J Biol Chem. 2010;285(45):35169-79. doi:10.1074/jbc.M110.164475  PMCID:PMC2966130  PMID:20817944  
  26. Fernandez-Boyanapalli R, McPhillips KA, Frasch SC, Janssen WJ, Dinauer MC, Riches DW, Henson PM, Byrne A, Bratton DL. Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-γ in a nitric oxide-dependent manner. J Immunol. 2010;185(7):4030-41. doi:10.4049/jimmunol.1001778  PMID:20805415  
  27. Nie B, Cheng N, Dinauer MC, Ye RD. Characterization of P-Rex1 for its role in fMet-Leu-Phe-induced superoxide production in reconstituted COS(phox) cells. Cell Signal. 2010;22(5):770-82. doi:10.1016/j.cellsig.2010.01.001  PMCID:PMC3282168  PMID:20074642  
  28. Lasater EA, Li F, Bessler WK, Estes ML, Vemula S, Hingtgen CM, Dinauer MC, Kapur R, Conway SJ, Ingram DA Jr. Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans. J Clin Invest. 2010;120(3):859-70. doi:10.1172/JCI41443  PMCID:PMC2827964  PMID:20160346  
  29. Lewis EM, Sergeant S, Ledford B, Stull N, Dinauer MC, McPhail LC. Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding. J Biol Chem. 2010;285(5):2959-67. doi:10.1074/jbc.M109.030643  PMCID:PMC2823407  PMID:19948736  
  30. Sadat MA, Dirscherl S, Sastry L, Dantzer J, Pech N, Griffin S, Hawkins T, Zhao Y, Barese CN, Cross S, Orazi A, An C, Goebel WS, Yoder MC, Li X, Grez M, Cornetta K, Mooney SD, Dinauer MC. Retroviral vector integration in post-transplant hematopoiesis in mice conditioned with either submyeloablative or ablative irradiation. Gene Ther. 2009;16(12):1452-64. doi:10.1038/gt.2009.96  PMCID:PMC2795029  PMID:19657370  
  31. Matute JD, Arias AA, Wright NA, Wrobel I, Waterhouse CC, Li XJ, Marchal CC, Stull ND, Lewis DB, Steele M, Kellner JD, Yu W, Meroueh SO, Nauseef WM, Dinauer MC. A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40 phox and selective defects in neutrophil NADPH oxidase activity. Blood. 2009;114(15):3309-15. doi:10.1182/blood-2009-07-231498  PMCID:PMC2759653  PMID:19692703  
  32. Huang J, Canadien V, Lam GY, Steinberg BE, Dinauer MC, Magalhaes MA, Glogauer M, Grinstein S, Brumell JH. Activation of antibacterial autophagy by NADPH oxidases. Proc Natl Acad Sci U S A. 2009;106(15):6226-31. doi:10.1073/pnas.0811045106  PMCID:PMC2664152  PMID:19339495  
  33. Li XJ, Tian W, Stull ND, Grinstein S, Atkinson S, Dinauer MC. A fluorescently tagged C-terminal fragment of p47phox detects NADPH oxidase dynamics during phagocytosis. Mol Biol Cell. 2009;20(5):1520-32. doi:10.1091/mbc.E08-06-0620  PMCID:PMC2649267  PMID:19129478  
  34. Distasi MR, Case J, Ziegler MA, Dinauer MC, Yoder MC, Haneline LS, Dalsing MC, Miller SJ, Labarrere CA, Murphy MP, Ingram DA, Unthank JL. Suppressed hindlimb perfusion in Rac2-/- and Nox2-/- mice does not result from impaired collateral growth. Am J Physiol Heart Circ Physiol. 2009;296(3):H877-86. doi:10.1152/ajpheart.00772.2008  PMCID:PMC2660231  PMID:19151256  
  35. Casbon AJ, Allen LA, Dunn KW, Dinauer MC. Macrophage NADPH oxidase flavocytochrome B localizes to the plasma membrane and Rab11-positive recycling endosomes. J Immunol. 2009;182(4):2325-39. doi:10.4049/jimmunol.0803476  PMCID:PMC2666390  PMID:19201887  
  36. von Löhneysen K, Noack D, Jesaitis AJ, Dinauer MC, Knaus UG. Mutational analysis reveals distinct features of the Nox4-p22 phox complex. J Biol Chem. 2008;283(50):35273-82. doi:10.1074/jbc.M804200200  PMCID:PMC2596391  PMID:18849343  
  37. Tian W, Li XJ, Stull ND, Ming W, Suh CI, Bissonnette SA, Yaffe MB, Grinstein S, Atkinson SJ, Dinauer MC. Fc gamma R-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome. Blood. 2008;112(9):3867-77. doi:10.1182/blood-2007-11-126029  PMCID:PMC2572805  PMID:18711001  
  38. Peters B, Dirscherl S, Dantzer J, Nowacki J, Cross S, Li X, Cornetta K, Dinauer MC, Mooney SD. Automated analysis of viral integration sites in gene therapy research using the SeqMap web resource. Gene Ther. 2008;15(18):1294-8. doi:10.1038/gt.2008.99  PMCID:PMC2766545  PMID:18580967  
  39. Gomez JC, Soltys J, Okano K, Dinauer MC, Doerschuk CM. The role of Rac2 in regulating neutrophil production in the bone marrow and circulating neutrophil counts. Am J Pathol. 2008;173(2):507-17. doi:10.2353/ajpath.2008.071059  PMCID:PMC2475787  PMID:18583316  
  40. Hu G, Ye RD, Dinauer MC, Malik AB, Minshall RD. Neutrophil caveolin-1 expression contributes to mechanism of lung inflammation and injury. Am J Physiol Lung Cell Mol Physiol. 2008;294(2):L178-86. doi:10.1152/ajplung.00263.2007  PMID:17993589  
  41. Grenda DS, Murakami M, Ghatak J, Xia J, Boxer LA, Dale D, Dinauer MC, Link DC. Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis. Blood. 2007;110(13):4179-87. doi:10.1182/blood-2006-11-057299  PMCID:PMC2234798  PMID:17761833  
  42. Li Y, Yan J, De P, Chang HC, Yamauchi A, Christopherson KW 2nd, Paranavitana NC, Peng X, Kim C, Munugalavadla V, Kapur R, Chen H, Shou W, Stone JC, Kaplan MH, Dinauer MC, Durden DL, Quilliam LA. Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins. J Immunol. 2007;179(12):8322-31. PMCID:PMC2722108  PMID:18056377  
  43. Cheng N, He R, Tian J, Dinauer MC, Ye RD. A critical role of protein kinase C delta activation loop phosphorylation in formyl-methionyl-leucyl-phenylalanine-induced phosphorylation of p47(phox) and rapid activation of nicotinamide adenine dinucleotide phosphate oxidase. J Immunol. 2007;179(11):7720-8. PMID:18025218  
  44. Chen J, He R, Minshall RD, Dinauer MC, Ye RD. Characterization of a mutation in the Phox homology domain of the NADPH oxidase component p40phox identifies a mechanism for negative regulation of superoxide production. J Biol Chem. 2007;282(41):30273-84. doi:10.1074/jbc.M704416200  PMID:17698849  
  45. Broxmeyer HE, Sehra S, Cooper S, Toney LM, Kusam S, Aloor JJ, Marchal CC, Dinauer MC, Dent AL. Aberrant regulation of hematopoiesis by T cells in BAZF-deficient mice. Mol Cell Biol. 2007;27(15):5275-85. doi:10.1128/MCB.01967-05  PMCID:PMC1952080  PMID:17526724  
  46. Broxmeyer HE, Mejia JA, Hangoc G, Barese C, Dinauer M, Cooper S. SDF-1/CXCL12 enhances in vitro replating capacity of murine and human multipotential and macrophage progenitor cells. Stem Cells Dev. 2007;16(4):589-96. doi:10.1089/scd.2007.0044  PMID:17784832  
  47. Barese C, Pech N, Dirscherl S, Meyers JL, Sinn AL, Yoder MC, Goebel WS, Dinauer MC. Granulocyte colony-stimulating factor prior to nonmyeloablative irradiation decreases murine host hematopoietic stem cell function and increases engraftment of donor marrow cells. Stem Cells. 2007;25(6):1578-85. doi:10.1634/stemcells.2006-0808  PMID:17347493  
  48. Nakano Y, Banfi B, Jesaitis AJ, Dinauer MC, Allen LA, Nauseef WM. Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3. Biochem J. 2007;403(1):97-108. doi:10.1042/BJ20060819  PMCID:PMC1828898  PMID:17140397  
  49. Ming W, Li S, Billadeau DD, Quilliam LA, Dinauer MC. The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity. Mol Cell Biol. 2007;27(1):312-23. doi:10.1128/MCB.00985-06  PMCID:PMC1800642  PMID:17060455  
  50. Zhu Y, Marchal CC, Casbon AJ, Stull N, von Löhneysen K, Knaus UG, Jesaitis AJ, McCormick S, Nauseef WM, Dinauer MC. Deletion mutagenesis of p22phox subunit of flavocytochrome b558: identification of regions critical for gp91phox maturation and NADPH oxidase activity. J Biol Chem. 2006;281(41):30336-46. doi:10.1074/jbc.M607191200  PMID:16895900  
  51. Pessach I, Shmelzer Z, Leto TL, Dinauer MC, Levy R. The C-terminal flavin domain of gp91phox bound to plasma membranes of granulocyte-like X-CGD PLB-985 cells is sufficient to anchor cytosolic oxidase components and support NADPH oxidase-associated diaphorase activity independent of cytosolic phospholipase A2 regulation. J Leukoc Biol. 2006;80(3):630-9. doi:10.1189/jlb.1105684  PMID:16844764  
  52. Suh CI, Stull ND, Li XJ, Tian W, Price MO, Grinstein S, Yaffe MB, Atkinson S, Dinauer MC. The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis. J Exp Med. 2006;203(8):1915-25. doi:10.1084/jem.20052085  PMCID:PMC2118377  PMID:16880255  
  53. Okada F, Kobayashi M, Tanaka H, Kobayashi T, Tazawa H, Iuchi Y, Onuma K, Hosokawa M, Dinauer MC, Hunt NH. The role of nicotinamide adenine dinucleotide phosphate oxidase-derived reactive oxygen species in the acquisition of metastatic ability of tumor cells. Am J Pathol. 2006;169(1):294-302. doi:10.2353/ajpath.2006.060073  PMCID:PMC1698756  PMID:16816381  
  54. Martyn KD, Frederick LM, von Loehneysen K, Dinauer MC, Knaus UG. Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. Cell Signal. 2006;18(1):69-82. doi:10.1016/j.cellsig.2005.03.023  PMID:15927447  
  55. Kim C, Dinauer MC. Impaired NADPH oxidase activity in Rac2-deficient murine neutrophils does not result from defective translocation of p47phox and p67phox and can be rescued by exogenous arachidonic acid. J Leukoc Biol. 2006;79(1):223-34. doi:10.1189/jlb.0705371  PMID:16275890  
  56. Meade VM, Barese CN, Kim C, Njinimbam CG, Marchal CC, Ingram DA, Clapp DW, Dinauer MC, Yoder MC. Rac2 concentrations in umbilical cord neutrophils. Biol Neonate. 2006;90(3):156-9. doi:10.1159/000092451  PMID:16582540  
  57. Martyn KD, Kim MJ, Quinn MT, Dinauer MC, Knaus UG. p21-activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils. Blood. 2005;106(12):3962-9. doi:10.1182/blood-2005-03-0859  PMCID:PMC1895105  PMID:16099876  
  58. Goebel WS, Mark LA, Billings SD, Meyers JL, Pech N, Travers JB, Dinauer MC. Gene correction reduces cutaneous inflammation and granuloma formation in murine X-linked chronic granulomatous disease. J Invest Dermatol. 2005;125(4):705-10. doi:10.1111/j.0022-202X.2005.23908.x  PMID:16185269  
  59. Potter SM, Mitchell AJ, Cowden WB, Sanni LA, Dinauer M, de Haan JB, Hunt NH. Phagocyte-derived reactive oxygen species do not influence the progression of murine blood-stage malaria infections. Infect Immun. 2005;73(8):4941-7. doi:10.1128/IAI.73.8.4941-4947.2005  PMCID:PMC1201219  PMID:16041008  
  60. Ramanuja S, Wolf KM, Sadat MA, Mahoney SJ, Dinauer MC, Nelson RP Jr. Newly diagnosed chronic granulomatous disease in a 53-year-old woman with Crohn disease. Ann Allergy Asthma Immunol. 2005;95(2):204-9. doi:10.1016/S1081-1206(10)61212-4  PMID:16136772  
  61. Carstanjen D, Yamauchi A, Koornneef A, Zang H, Filippi MD, Harris C, Towe J, Atkinson S, Zheng Y, Dinauer MC, Williams DA. Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways. J Immunol. 2005;174(8):4613-20. PMID:15814684  
  62. Baniulis D, Burritt JB, Taylor RM, Dinauer MC, Heyworth PG, Parkos CA, Magnusson KE, Jesaitis AJ. Monoclonal antibody CL5 recognizes the amino terminal domain of human phagocyte flavocytochrome b558 large subunit, gp91phox. Eur J Haematol. 2005;74(4):337-47. doi:10.1111/j.1600-0609.2004.00380.x  PMID:15777347  
  63. Baniulis D, Nauseef WM, Burritt JB, Taylor RM, Heyworth PG, Dinauer MC, Bumelis VA, Magnusson KE, Jesaitis AJ. Unusual polyclonal anti-gp91 peptide antibody interactions with X-linked chronic granulomatous disease-derived human neutrophils are not from compensatory expression of Nox proteins 1, 3, or 4. Eur J Haematol. 2005;74(3):241-9. doi:10.1111/j.1600-0609.2004.00357.x  PMID:15693794  
  64. Yamauchi A, Marchal CC, Molitoris J, Pech N, Knaus U, Towe J, Atkinson SJ, Dinauer MC. Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo. Role of the C-terminal polybasic domain. J Biol Chem. 2005;280(2):953-64. doi:10.1074/jbc.M408820200  PMID:15504745  
  65. Matute JD, Arias AA, Dinauer MC, Patiño PJ. p40phox: the last NADPH oxidase subunit. Blood Cells Mol Dis. 2005;35(2):291-302. doi:10.1016/j.bcmd.2005.06.010  PMID:16102984  
  66. He R, Nanamori M, Sang H, Yin H, Dinauer MC, Ye RD. Reconstitution of chemotactic peptide-induced nicotinamide adenine dinucleotide phosphate (reduced) oxidase activation in transgenic COS-phox cells. J Immunol. 2004;173(12):7462-70. PMID:15585872  
  67. Taylor RM, Burritt JB, Baniulis D, Foubert TR, Lord CI, Dinauer MC, Parkos CA, Jesaitis AJ. Site-specific inhibitors of NADPH oxidase activity and structural probes of flavocytochrome b: characterization of six monoclonal antibodies to the p22phox subunit. J Immunol. 2004;173(12):7349-57. PMID:15585859  
  68. Goebel WS, Pech NK, Meyers JL, Srour EF, Yoder MC, Dinauer MC. A murine model of antimetabolite-based, submyeloablative conditioning for bone marrow transplantation: biologic insights and potential applications. Exp Hematol. 2004;32(12):1255-64. doi:10.1016/j.exphem.2004.08.007  PMID:15588950  
  69. Yamauchi A, Kim C, Li S, Marchal CC, Towe J, Atkinson SJ, Dinauer MC. Rac2-deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles. J Immunol. 2004;173(10):5971-9. PMID:15528331  
  70. Aratani Y, Kura F, Watanabe H, Akagawa H, Takano Y, Suzuki K, Dinauer MC, Maeda N, Koyama H. In vivo role of myeloperoxidase for the host defense. Jpn J Infect Dis. 2004;57(5):S15. PMID:15507755  
  71. Kobayashi T, Ogawa Y, Watanabe Y, Furuya M, Kataoka S, Garcia del Saz E, Tsunawaki S, Dinauer MC, Seguchi H. Mitochondrial transmembrane potential is diminished in phorbol myristate acetate-stimulated peritoneal resident macrophages isolated from wild-type mice, but not in those from gp91-phox-deficient mice. Histochem Cell Biol. 2004;122(4):323-32. doi:10.1007/s00418-004-0674-0  PMID:15243751  
  72. Arias AA, Dinauer MC, Ding J, Matute JD, Patiño PJ. [Expression and activity of polymorphisms in the 67-kDa protein of the NADPH oxidase system]. Biomedica. 2004;24(3):262-72. PMID:15551878  
  73. Abdel-Latif D, Steward M, Macdonald DL, Francis GA, Dinauer MC, Lacy P. Rac2 is critical for neutrophil primary granule exocytosis. Blood. 2004;104(3):832-9. doi:10.1182/blood-2003-07-2624  PMID:15073033  
  74. Diebold BA, Fowler B, Lu J, Dinauer MC, Bokoch GM. Antagonistic cross-talk between Rac and Cdc42 GTPases regulates generation of reactive oxygen species. J Biol Chem. 2004;279(27):28136-42. doi:10.1074/jbc.M313891200  PMID:15123662  
  75. Goebel WS, Pech NK, Dinauer MC. Stable long-term gene correction with low-dose radiation conditioning in murine X-linked chronic granulomatous disease. Blood Cells Mol Dis. 2004;33(3):365-71. doi:10.1016/j.bcmd.2004.06.007  PMID:15528159  
  76. Kim C, Marchal CC, Penninger J, Dinauer MC. The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl-leucyl-phenylalanine-activated neutrophil functions. J Immunol. 2003;171(8):4425-30. PMID:14530369  
  77. Glogauer M, Marchal CC, Zhu F, Worku A, Clausen BE, Foerster I, Marks P, Downey GP, Dinauer M, Kwiatkowski DJ. Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions. J Immunol. 2003;170(11):5652-7. PMID:12759446  
  78. Sadat MA, Pech N, Saulnier S, Leroy BA, Hossle JP, Grez M, Dinauer MC. Long-term high-level reconstitution of NADPH oxidase activity in murine X-linked chronic granulomatous disease using a bicistronic vector expressing gp91phox and a Delta LNGFR cell surface marker. Hum Gene Ther. 2003;14(7):651-66. doi:10.1089/104303403321618164  PMID:12804147  
  79. Bonini C, Grez M, Traversari C, Ciceri F, Marktel S, Ferrari G, Dinauer M, Sadat M, Aiuti A, Deola S, Radrizzani M, Hagenbeek A, Apperley J, Ebeling S, Martens A, Kolb HJ, Weber M, Lotti F, Grande A, Weissinger E, Bueren JA, Lamana M, Falkenburg JH, Heemskerk MH, Austin T, Kornblau S, Marini F, Benati C, Magnani Z, Cazzaniga S, Toma S, Gallo-Stampino C, Introna M, Slavin S, Greenberg PD, Bregni M, Mavilio F, Bordignon C. Safety of retroviral gene marking with a truncated NGF receptor. Nat Med. 2003;9(4):367-9. doi:10.1038/nm0403-367  PMID:12669036  
  80. Dinauer MC. Regulation of neutrophil function by Rac GTPases. Curr Opin Hematol. 2003;10(1):8-15. PMID:12483106  
  81. Aratani Y, Kura F, Watanabe H, Akagawa H, Takano Y, Suzuki K, Dinauer MC, Maeda N, Koyama H. Relative contributions of myeloperoxidase and NADPH-oxidase to the early host defense against pulmonary infections with Candida albicans and Aspergillus fumigatus. Med Mycol. 2002;40(6):557-63. PMID:12521119  
  82. Goebel WS, Dinauer MC. Retroviral-mediated gene transfer and nonmyeloablative conditioning: studies in a murine X-linked chronic granulomatous disease model. J Pediatr Hematol Oncol. 2002;24(9):787-90. PMID:12468930  
  83. Li S, Yamauchi A, Marchal CC, Molitoris JK, Quilliam LA, Dinauer MC. Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions. J Immunol. 2002;169(9):5043-51. PMID:12391220  
  84. Goebel WS, Yoder MC, Pech NK, Dinauer MC. Donor chimerism and stem cell function in a murine congenic transplantation model after low-dose radiation conditioning: effects of a retroviral-mediated gene transfer protocol and implications for gene therapy. Exp Hematol. 2002;30(11):1324-32. PMID:12423686  
  85. Biberstine-Kinkade KJ, Yu L, Stull N, LeRoy B, Bennett S, Cross A, Dinauer MC. Mutagenesis of p22(phox) histidine 94. A histidine in this position is not required for flavocytochrome b558 function. J Biol Chem. 2002;277(33):30368-74. doi:10.1074/jbc.M203993200  PMID:12042318  
  86. Aratani Y, Kura F, Watanabe H, Akagawa H, Takano Y, Suzuki K, Dinauer MC, Maeda N, Koyama H. Critical role of myeloperoxidase and nicotinamide adenine dinucleotide phosphate-oxidase in high-burden systemic infection of mice with Candida albicans. J Infect Dis. 2002;185(12):1833-7. doi:10.1086/340635  PMID:12085336  
  87. Morgan D, Cherny VV, Price MO, Dinauer MC, DeCoursey TE. Absence of proton channels in COS-7 cells expressing functional NADPH oxidase components. J Gen Physiol. 2002;119(6):571-80. PMCID:PMC2233867  PMID:12034764  
  88. Price MO, Atkinson SJ, Knaus UG, Dinauer MC. Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent. J Biol Chem. 2002;277(21):19220-8. doi:10.1074/jbc.M200061200  PMID:11896053  
  89. Gao XP, Standiford TJ, Rahman A, Newstead M, Holland SM, Dinauer MC, Liu QH, Malik AB. Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by Gram-negative sepsis: studies in p47phox-/- and gp91phox-/- mice. J Immunol. 2002;168(8):3974-82. PMID:11937554  
  90. Price MO, McPhail LC, Lambeth JD, Han CH, Knaus UG, Dinauer MC. Creation of a genetic system for analysis of the phagocyte respiratory burst: high-level reconstitution of the NADPH oxidase in a nonhematopoietic system. Blood. 2002;99(8):2653-61. PMID:11929750  
  91. Petersen JE, Hiran TS, Goebel WS, Johnson C, Murphy RC, Azmi FH, Hood AF, Travers JB, Dinauer MC. Enhanced cutaneous inflammatory reactions to Aspergillus fumigatus in a murine model of chronic granulomatous disease. J Invest Dermatol. 2002;118(3):424-9. doi:10.1046/j.0022-202x.2001.01691.x  PMID:11874480  
  92. Hiran T, Dinauer M, Johnson C, Clay K, Travers J. Evidence for the involvement of the NADPH oxidase enzyme complex in the optimal accumulation of Platelet-activating factor in the human cell line PLB-985. Prostaglandins Other Lipid Mediat. 2001;66(4):305-15. PMID:11785782  
  93. DeCoursey TE, Cherny VV, Morgan D, Katz BZ, Dinauer MC. The gp91phox component of NADPH oxidase is not the voltage-gated proton channel in phagocytes, but it helps. J Biol Chem. 2001;276(39):36063-6. doi:10.1074/jbc.C100352200  PMID:11477065  
  94. Biberstine-Kinkade KJ, DeLeo FR, Epstein RI, LeRoy BA, Nauseef WM, Dinauer MC. Heme-ligating histidines in flavocytochrome b(558): identification of specific histidines in gp91(phox). J Biol Chem. 2001;276(33):31105-12. doi:10.1074/jbc.M103327200  PMID:11413138  
  95. Dinauer MC, Gifford MA, Pech N, Li LL, Emshwiller P. Variable correction of host defense following gene transfer and bone marrow transplantation in murine X-linked chronic granulomatous disease. Blood. 2001;97(12):3738-45. PMID:11389011  
  96. Burritt JB, DeLeo FR, McDonald CL, Prigge JR, Dinauer MC, Nakamura M, Nauseef WM, Jesaitis AJ. Phage display epitope mapping of human neutrophil flavocytochrome b558. Identification of two juxtaposed extracellular domains. J Biol Chem. 2001;276(3):2053-61. doi:10.1074/jbc.M006236200  PMID:11027685  
  97. Kim C, Dinauer MC. Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways. J Immunol. 2001;166(2):1223-32. PMID:11145705  
  98. Potter SM, Sanni L, Simasathiansophon S, Dinauer MC, Hunt NH. Phagocyte-derived reactive oxygen species and the immunology and pathology of murine malaria. Redox Rep. 2001;6(3):200-3. doi:10.1179/135100001101536210  PMID:11523600  
  99. van Reyk DM, King NJ, Dinauer MC, Hunt NH. The intracellular oxidation of 2',7'-dichlorofluorescin in murine T lymphocytes. Free Radic Biol Med. 2001;30(1):82-8. PMID:11134898  
  100. Yamauchi A, Yu L, Pötgens AJ, Kuribayashi F, Nunoi H, Kanegasaki S, Roos D, Malech HL, Dinauer MC, Nakamura M. Location of the epitope for 7D5, a monoclonal antibody raised against human flavocytochrome b558, to the extracellular peptide portion of primate gp91phox. Microbiol Immunol. 2001;45(3):249-57. PMID:11345535  
  101. Ozaki M, Deshpande S, Angkeow P, Bellan J, Lowenstein CJ, Dinauer MC, Goldschmidt-Clermont P, Suzuki S, Irani K. Targeted inhibition of the small GTPase protects against ischemia/reperfusion liver injury in mice. Transplant Proc. 2001;33(1-2):863-4. PMID:11267105  
  102. Beck PL, Xavier R, Lu N, Nanda NN, Dinauer M, Podolsky DK, Seed B. Mechanisms of NSAID-induced gastrointestinal injury defined using mutant mice. Gastroenterology. 2000;119(3):699-705. PMID:10982764  
  103. Williams DA, Tao W, Yang F, Kim C, Gu Y, Mansfield P, Levine JE, Petryniak B, Derrow CW, Harris C, Jia B, Zheng Y, Ambruso DR, Lowe JB, Atkinson SJ, Dinauer MC, Boxer L. Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency. Blood. 2000;96(5):1646-54. PMID:10961859  
  104. Kirk EA, Dinauer MC, Rosen H, Chait A, Heinecke JW, LeBoeuf RC. Impaired superoxide production due to a deficiency in phagocyte NADPH oxidase fails to inhibit atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 2000;20(6):1529-35. PMID:10845868  
  105. DeLeo FR, Burritt JB, Yu L, Jesaitis AJ, Dinauer MC, Nauseef WM. Processing and maturation of flavocytochrome b558 include incorporation of heme as a prerequisite for heterodimer assembly. J Biol Chem. 2000;275(18):13986-93. PMID:10788525  
  106. Grez M, Becker S, Saulnier S, Knöss H, Ott MG, Maurer A, Dinauer MC, Hoelzer D, Seger R, Hossle JP. Gene therapy of chronic granulomatous disease. Bone Marrow Transplant. 2000;25 Suppl 2:S99-104. PMID:10933200  
  107. Yang FC, Kapur R, King AJ, Tao W, Kim C, Borneo J, Breese R, Marshall M, Dinauer MC, Williams DA. Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells. Immunity. 2000;12(5):557-68. PMID:10843388  
  108. Fu XW, Wang D, Nurse CA, Dinauer MC, Cutz E. NADPH oxidase is an O2 sensor in airway chemoreceptors: evidence from K+ current modulation in wild-type and oxidase-deficient mice. Proc Natl Acad Sci U S A. 2000;97(8):4374-9. PMCID:PMC18249  PMID:10760304  
  109. Vazquez-Torres A, Xu Y, Jones-Carson J, Holden DW, Lucia SM, Dinauer MC, Mastroeni P, Fang FC. Salmonella pathogenicity island 2-dependent evasion of the phagocyte NADPH oxidase. Science. 2000;287(5458):1655-8. PMID:10698741  
  110. Ozaki M, Deshpande SS, Angkeow P, Bellan J, Lowenstein CJ, Dinauer MC, Goldschmidt-Clermont PJ, Irani K. Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion-induced necrosis and apoptosis in vivo. FASEB J. 2000;14(2):418-29. PMID:10657998  
  111. Saulnier SO, Steinhoff D, Dinauer MC, Zufferey R, Trono D, Seger RA, Hossle JP. Lentivirus-mediated gene transfer of gp91phox corrects chronic granulomatous disease (CGD) phenotype in human X-CGD cells. J Gene Med. 2000;2(5):317-25. doi:10.1002/1521-2254(200009/10)2:5<317::AID-JGM127>3.0.CO;2-P  PMID:11045425  
  112. Zentilin L, Qin G, Tafuro S, Dinauer MC, Baum C, Giacca M. Variegation of retroviral vector gene expression in myeloid cells. Gene Ther. 2000;7(2):153-66. doi:10.1038/sj.gt.3301057  PMID:10673720  
  113. Yu L, Cross AR, Zhen L, Dinauer MC. Functional analysis of NADPH oxidase in granulocytic cells expressing a delta488-497 gp91(phox) deletion mutant. Blood. 1999;94(7):2497-504. PMID:10498623  
  114. Dinauer MC, Li LL, Björgvinsdóttir H, Ding C, Pech N. Long-term correction of phagocyte NADPH oxidase activity by retroviral-mediated gene transfer in murine X-linked chronic granulomatous disease. Blood. 1999;94(3):914-22. PMID:10419882  
  115. Archer SL, Reeve HL, Michelakis E, Puttagunta L, Waite R, Nelson DP, Dinauer MC, Weir EK. O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase. Proc Natl Acad Sci U S A. 1999;96(14):7944-9. PMCID:PMC22167  PMID:10393927  
  116. Biberstine-Kinkade KJ, Yu L, Dinauer MC. Mutagenesis of an arginine- and lysine-rich domain in the gp91(phox) subunit of the phagocyte NADPH-oxidase flavocytochrome b558. J Biol Chem. 1999;274(15):10451-7. PMID:10187835  
  117. Nicholson SC, Grobmyer SR, Shiloh MU, Brause JE, Potter S, MacMicking JD, Dinauer MC, Nathan CF. Lethality of endotoxin in mice genetically deficient in the respiratory burst oxidase, inducible nitric oxide synthase, or both. Shock. 1999;11(4):253-8. PMID:10220301  
  118. Ou X, Pollock J, Dinauer MC, Gharehbaghi-Schnell E, Skalnik DG. Identification and functional characterization of the murine Rac2 gene promoter. DNA Cell Biol. 1999;18(3):253-63. doi:10.1089/104454999315475  PMID:10098607  
  119. Yu L, DeLeo FR, Biberstine-Kinkade KJ, Renee J, Nauseef WM, Dinauer MC. Biosynthesis of flavocytochrome b558 . gp91(phox) is synthesized as a 65-kDa precursor (p65) in the endoplasmic reticulum. J Biol Chem. 1999;274(7):4364-9. PMID:9933639  
  120. Roberts AW, Kim C, Zhen L, Lowe JB, Kapur R, Petryniak B, Spaetti A, Pollock JD, Borneo JB, Bradford GB, Atkinson SJ, Dinauer MC, Williams DA. Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Immunity. 1999;10(2):183-96. PMID:10072071  
  121. Shiloh MU, MacMicking JD, Nicholson S, Brause JE, Potter S, Marino M, Fang F, Dinauer M, Nathan C. Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase. Immunity. 1999;10(1):29-38. PMID:10023768  
  122. Sanni LA, Fu S, Dean RT, Bloomfield G, Stocker R, Chaudhri G, Dinauer MC, Hunt NH. Are reactive oxygen species involved in the pathogenesis of murine cerebral malaria? J Infect Dis. 1999;179(1):217-22. doi:10.1086/314552  PMID:9841842  
  123. Lundberg BE, Wolf RE Jr, Dinauer MC, Xu Y, Fang FC. Glucose 6-phosphate dehydrogenase is required for Salmonella typhimurium virulence and resistance to reactive oxygen and nitrogen intermediates. Infect Immun. 1999;67(1):436-8. PMCID:PMC96332  PMID:9864251  
  124. Li LL, Dinauer. Reconstitution of NADPH oxidase activity in human X-linked chronic granulomatous disease myeloid cells after stable gene transfer using a recombinant adeno-associated virus 2 vector. Blood Cells Mol Dis. 1998;24(4):522-38. PMID:9880243  
  125. Al-Mehdi AB, Zhao G, Dodia C, Tozawa K, Costa K, Muzykantov V, Ross C, Blecha F, Dinauer M, Fisher AB. Endothelial NADPH oxidase as the source of oxidants in lungs exposed to ischemia or high K+. Circ Res. 1998;83(7):730-7. PMID:9758643  
  126. Becker S, Wasser S, Hauses M, Hossle JP, Ott MG, Dinauer MC, Ganser A, Hoelzer D, Seger R, Grez M. Correction of respiratory burst activity in X-linked chronic granulomatous cells to therapeutically relevant levels after gene transfer into bone marrow CD34+ cells. Hum Gene Ther. 1998;9(11):1561-70. doi:10.1089/hum.1998.9.11-1561  PMID:9694155  
  127. Yu L, Quinn MT, Cross AR, Dinauer MC. Gp91(phox) is the heme binding subunit of the superoxide-generating NADPH oxidase. Proc Natl Acad Sci U S A. 1998;95(14):7993-8. PMCID:PMC20917  PMID:9653128  
  128. Rae J, Newburger PE, Dinauer MC, Noack D, Hopkins PJ, Kuruto R, Curnutte JT. X-Linked chronic granulomatous disease: mutations in the CYBB gene encoding the gp91-phox component of respiratory-burst oxidase. Am J Hum Genet. 1998;62(6):1320-31. doi:10.1086/301874  PMCID:PMC1377153  PMID:9585602  
  129. Zhen L, Yu L, Dinauer MC. Probing the role of the carboxyl terminus of the gp91phox subunit of neutrophil flavocytochrome b558 using site-directed mutagenesis. J Biol Chem. 1998;273(11):6575-81. PMID:9497394  
  130. De Groote MA, Ochsner UA, Shiloh MU, Nathan C, McCord JM, Dinauer MC, Libby SJ, Vazquez-Torres A, Xu Y, Fang FC. Periplasmic superoxide dismutase protects Salmonella from products of phagocyte NADPH-oxidase and nitric oxide synthase. Proc Natl Acad Sci U S A. 1997;94(25):13997-4001. PMCID:PMC28421  PMID:9391141  
  131. Walder CE, Green SP, Darbonne WC, Mathias J, Rae J, Dinauer MC, Curnutte JT, Thomas GR. Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase. Stroke. 1997;28(11):2252-8. PMID:9368573  
  132. Yu L, Zhen L, Dinauer MC. Biosynthesis of the phagocyte NADPH oxidase cytochrome b558. Role of heme incorporation and heterodimer formation in maturation and stability of gp91phox and p22phox subunits. J Biol Chem. 1997;272(43):27288-94. PMID:9341176  
  133. Dinauer MC, Deck MB, Unanue ER. Mice lacking reduced nicotinamide adenine dinucleotide phosphate oxidase activity show increased susceptibility to early infection with Listeria monocytogenes. J Immunol. 1997;158(12):5581-3. PMID:9190903  
  134. Morgenstern DE, Gifford MA, Li LL, Doerschuk CM, Dinauer MC. Absence of respiratory burst in X-linked chronic granulomatous disease mice leads to abnormalities in both host defense and inflammatory response to Aspergillus fumigatus. J Exp Med. 1997;185(2):207-18. PMCID:PMC2196125  PMID:9016870  
  135. Adams LB, Dinauer MC, Morgenstern DE, Krahenbuhl JL. Comparison of the roles of reactive oxygen and nitrogen intermediates in the host response to Mycobacterium tuberculosis using transgenic mice. Tuber Lung Dis. 1997;78(5-6):237-46. PMID:10209678  
  136. Björgvinsdóttir H, Ding C, Pech N, Gifford MA, Li LL, Dinauer MC. Retroviral-mediated gene transfer of gp91phox into bone marrow cells rescues defect in host defense against Aspergillus fumigatus in murine X-linked chronic granulomatous disease. Blood. 1997;89(1):41-8. PMID:8978275  
  137. Wang D, Youngson C, Wong V, Yeger H, Dinauer MC, Vega-Saenz Miera E, Rudy B, Cutz E. NADPH-oxidase and a hydrogen peroxide-sensitive K+ channel may function as an oxygen sensor complex in airway chemoreceptors and small cell lung carcinoma cell lines. Proc Natl Acad Sci U S A. 1996;93(23):13182-7. PMCID:PMC24067  PMID:8917565  
  138. Roos D. X-CGDbase: a database of X-CGD-causing mutations. Immunol Today. 1996;17(11):517-521. PMID:8961628  
  139. Ding C, Kume A, Björgvinsdóttir H, Hawley RG, Pech N, Dinauer MC. High-level reconstitution of respiratory burst activity in a human X-linked chronic granulomatous disease (X-CGD) cell line and correction of murine X-CGD bone marrow cells by retroviral-mediated gene transfer of human gp91phox. Blood. 1996;88(5):1834-40. PMID:8781441  
  140. Kubo H, Morgenstern D, Quinian WM, Ward PA, Dinauer MC, Doerschuk CM. Preservation of complement-induced lung injury in mice with deficiency of NADPH oxidase. J Clin Invest. 1996;97(11):2680-4. doi:10.1172/JCI118718  PMCID:PMC507356  PMID:8647963  
  141. Björgvinsdóttir H, Zhen L, Dinauer MC. Cloning of murine gp91phox cDNA and functional expression in a human X-linked chronic granulomatous disease cell line. Blood. 1996;87(5):2005-10. PMID:8634451  
  142. Pollock JD, Williams DA, Gifford MA, Li LL, Du X, Fisherman J, Orkin SH, Doerschuk CM, Dinauer MC. Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nat Genet. 1995;9(2):202-9. doi:10.1038/ng0295-202  PMID:7719350  
  143. Newburger PE, Malawista SE, Dinauer MC, Gelbart T, Woodman RC, Chada S, Shen Q, van Blaricom G, Quie PG, Curnutte JT. Chronic granulomatous disease and glutathione peroxidase deficiency, revisited. Blood. 1994;84(11):3861-9. PMID:7949143  
  144. Kume A, Dinauer MC. Retrovirus-mediated reconstitution of respiratory burst activity in X-linked chronic granulomatous disease cells. Blood. 1994;84(10):3311-6. PMID:7949086  
  145. Maly FE, Schuerer-Maly CC, Quilliam L, Cochrane CG, Newburger PE, Curnutte JT, Gifford M, Dinauer MC. Restitution of superoxide generation in autosomal cytochrome-negative chronic granulomatous disease (A22(0) CGD)-derived B lymphocyte cell lines by transfection with p22phax cDNA. J Exp Med. 1993;178(6):2047-53. PMCID:PMC2191282  PMID:8245781  
  146. Zhen L, King AA, Xiao Y, Chanock SJ, Orkin SH, Dinauer MC. Gene targeting of X chromosome-linked chronic granulomatous disease locus in a human myeloid leukemia cell line and rescue by expression of recombinant gp91phox. Proc Natl Acad Sci U S A. 1993;90(21):9832-6. PMCID:PMC47666  PMID:8234321  
  147. de Boer M, Bolscher BG, Dinauer MC, Orkin SH, Smith CI, Ahlin A, Weening RS, Roos D. Splice site mutations are a common cause of X-linked chronic granulomatous disease. Blood. 1992;80(6):1553-8. PMID:1520880  
  148. Schapiro BL, Newburger PE, Klempner MS, Dinauer MC. Chronic granulomatous disease presenting in a 69-year-old man. N Engl J Med. 1991;325(25):1786-90. doi:10.1056/NEJM199112193252506  PMID:1719419  
  149. Dinauer MC, Pierce EA, Erickson RW, Muhlebach TJ, Messner H, Orkin SH, Seger RA, Curnutte JT. Point mutation in the cytoplasmic domain of the neutrophil p22-phox cytochrome b subunit is associated with a nonfunctional NADPH oxidase and chronic granulomatous disease. Proc Natl Acad Sci U S A. 1991;88(24):11231-5. PMCID:PMC53108  PMID:1763037  
  150. Ezekowitz RA, Sieff CA, Dinauer MC, Nathan DG, Orkin SH, Newburger PE. Restoration of phagocyte function by interferon-gamma in X-linked chronic granulomatous disease occurs at the level of a progenitor cell. Blood. 1990;76(12):2443-8. PMID:2176110  
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