Mary C. Dinauer, M.D., Ph.D.  dinauer_m@kids.wustl.edu

Fred M. Saigh Distinguished Chair in Pediatric Research, Washington University School of Medicine
Professor, Pathology & Immunology
Scientific Director, Children's Discovery Institute, Washington University School of Medicine
Pathology & ImmunologyDevelopmental BiologyHematology and OncologyPediatrics

phone: (314) 454-6018

Clinical Interests

Research interests: Dr. Dinauer studies the superoxide-generating leukocyte NADPH oxidase and the role of oxidant production by neutrophils and macrophages in microbial killing, the inflammatory response, and autoimmunity. Inactivating mutations in the NADPH oxidase result in chronic granulomatous disease (CGD), a primary immunodeficiency associated with recurrent bacterial and fungal infections as well as a variety of chronic inflammatory disorders, including inflammatory bowel disease and discoid lupus. Moreover, hypomorphic NADPH oxidase gene variants are now linked to inflammatory bowel disease and autoimmunity. These clinical manifestations reflect the dual importance of the NADPH oxidase both for microbial killing and for negatively regulating cellular processes that limit inflammation by redox mechanisms.

Education

  • BA, Lawrence University1975
  • PhD, University of Chicago1979
  • MD, University of Chicago1981

Training

  • Internship and Residency in Pediatrics, University of California1981 - 1984
  • Chief Residency in Pediatrics, University of California1984 - 1985
  • Fellowship in Pediatric Hematology/Oncology, Children’s Hospital and Dana-Farber Cancer Institute, Harvard Medical School1985 - 1988

Licensure and Board Certification

  • National Board of Medical Examiners 1982
  • CA, California License 1983
  • MA, Massachusetts License 1986
  • American Board of Pediatrics 1986
  • IN, Indiana License 1991
  • MO, Missouri License 2012

Honors

  • Phi Beta Kappa1974
  • Summa Cum Laude, Lawrence University1975
  • Medical Scientist Training Program1975 - 1981
  • Alpha Omega Alpha1981
  • American Medical Women's Association Award, University of Chicago1981
  • Mary Roberts Scott Memorial Prize, University of Chicago1981
  • Medical Doctorate, with Honors, University of Chicago1981
  • Basil O'Connor Starter Scholar Research Award, March of Dimes1990 - 1992
  • JV Satterfield Arthritis Investigator, Arthritis Foundation1990 - 1993
  • American Society of Clinical Investigation1995
  • Excellence in Pediatrics Research Award, American Academy of Pediatrics1995
  • Soroptimist International of Indianapolis, Woman of Distinction Honoree1996
  • Lucia R. Briggs Distinguished Achievement Award, Lawrence University2000
  • Association of American Physicians2008
  • Fellow, American Association for the Advancement of Science2014

Recent Publications view all (169)


Publication Co-Authors

  1. Enhanced expression of CXCR4 facilitates c-kit-targeted CAR-T cell trafficking to BM and enables donor HSC engraftment. Submitted. 2017. 
  2. NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages. In revision. 2017. 
  3. Inherited p40phox deficiency is related to but different from classical chronic granulomatous disease. Submitted. 2017. 
  4. Somatic Mutations And Clonal Hematopoiesis In Congenital Neutropenia. Blood, in press. 2017. 
  5. Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense. Cell Rep. 2017;19(5):1008-1021. PMCID:PMC5512462  PMID:28467895 
  6. Haploinsufficiency of NADPH Oxidase Subunit Neutrophil Cytosolic Factor 2 Is Sufficient to Accelerate Full-Blown Lupus in NZM 2328 Mice. Arthritis Rheumatol. 2017;69(8):1647-1660. PMID:28471497 
  7. PI(3)P-p40phox binding regulates NADPH oxidase activation in mouse macrophages and magnitude of inflammatory responses in vivo. J Leukoc Biol. 2017;101(2):449-457. PMID:27543673 
  8. Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis. Cell Host Microbe. 2016;19(1):102-13. PMCID:PMC4714358  PMID:26764600 
  9. NADPH oxidase controls neutrophilic response to sterile inflammation in mice by regulating the IL-1α/G-CSF axis. Blood. 2015;17(126(25)):2724-33. doi:10.1182/blood-2015-05-644773  PMID:26443623 
  10. Hyper-responsive Toll-like receptor 7 and 9 activation in NADPH oxidase-deficient B lymphoblasts. Immunology. 2015;146(4):595-606. doi:10.1111/imm.12530  PMCID:4693894  PMID:26340429 
  11. Mechanisms of interferon-γ production by neutrophils and its function during Streptococcus pneumoniae pneumonia. Am J Respir Cell Mol Biol. 2015;52(3):349-64. doi:10.1165/rcmb.2013-0316OC  PMCID:PMC4370257  PMID:25100610 
  12. Two CGD Families with a Hypomorphic Mutation in the Activation Domain of p67phox. J Clin Cell Immunol. 2014;5(3). PMCID:PMC4414043  PMID:25937994 
  13. Cupric yersiniabactin is a virulence-associated superoxide dismutase mimic. ACS Chem Biol. 2014;9(2):551-61. doi:10.1021/cb400658k  PMCID:PMC3934373  PMID:24283977 
  14. Primary Immune Deficiency Treatment Consortium (PIDTC) report. J Allergy Clin Immunol. 2014;133(2):335-47. doi:10.1016/j.jaci.2013.07.052  PMCID:PMC3960312  PMID:24139498 
  15. Autophagy proteins control goblet cell function by potentiating reactive oxygen species production. EMBO J. 2013;32(24):3130-44. doi:10.1038/emboj.2013.233  PMCID:PMC3981139  PMID:24185898 
  16. Regulation of the NADPH oxidase and associated ion fluxes during phagocytosis. Traffic. 2013;14(11):1118-1131. doi:10.1111/tra.12115  PMID:23980663 
  17. From bench to bedside: preclinical evaluation of a self-inactivating gammaretroviral vector for the gene therapy of X-linked chronic granulomatous disease. Hum Gene Ther Clin Dev. 2013;24(2):86-98. doi:10.1089/humc.2013.019  PMID:23845071 
  18. An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD. Blood. 2013;121(17):3473-83. doi:10.1182/blood-2012-10-461913  PMCID:PMC3637016  PMID:23426944 
  19. Activation of neutrophil respiratory burst by fungal particles requires phosphatidylinositol 3-phosphate binding to p40(phox) in humans but not in mice. Blood. 2012;120(16):3385-7. doi:10.1182/blood-2012-07-445619  PMID:23086626 
  20. Cutting edge: NADPH oxidase modulates MHC class II antigen presentation by B cells. J Immunol. 2012;189(8):3800-4. doi:10.4049/jimmunol.1103080  PMCID:PMC3466399  PMID:22984083 
  21. Effects of IFN-γ on intracellular trafficking and activity of macrophage NADPH oxidase flavocytochrome b558. J Leukoc Biol. 2012;92(4):869-82. doi:10.1189/jlb.0512244  PMCID:PMC3441311  PMID:22822009 
  22. Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase. Proc Natl Acad Sci U S A. 2012;109(2):E59-67. doi:10.1073/pnas.1113251108  PMCID:PMC3258621  PMID:22203994 
  23. Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2. Proc Natl Acad Sci U S A. 2011;108(49):19617-22. doi:10.1073/pnas.1114692108  PMCID:PMC3241757  PMID:22106281 
  24. The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxis. Mol Cell Biol. 2011;31(11):2227-40. doi:10.1128/MCB.01348-10  PMCID:PMC3133238  PMID:21444720 
  25. Interferon-γ production by neutrophils during bacterial pneumonia in mice. Am J Respir Crit Care Med. 2011;183(10):1391-401. doi:10.1164/rccm.201004-0592OC  PMCID:PMC3114063  PMID:21169470 
  26. Evidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2. J Biol Chem. 2011;286(18):16308-20. doi:10.1074/jbc.M110.206672  PMCID:PMC3091237  PMID:21378159 
  27. Germline CYBB mutations that selectively affect macrophages in kindreds with X-linked predisposition to tuberculous mycobacterial disease. Nat Immunol. 2011;12(3):213-21. doi:10.1038/ni.1992  PMCID:PMC3097900  PMID:21278736 
  28. Identifying viral integration sites using SeqMap 2.0. Bioinformatics. 2011;27(5):720-2. doi:10.1093/bioinformatics/btq722  PMCID:PMC3042184  PMID:21245052 
  29. Gene therapy of chronic granulomatous disease: the engraftment dilemma. Mol Ther. 2011;19(1):28-35. doi:10.1038/mt.2010.232  PMCID:PMC3017455  PMID:21045810 
  30. Antibody targeting KIT as pretransplantation conditioning in immunocompetent mice. Blood. 2010;116(24):5419-22. doi:10.1182/blood-2010-07-295949  PMCID:PMC3012550  PMID:20813896 
  31. p47phox Phox homology domain regulates plasma membrane but not phagosome neutrophil NADPH oxidase activation. J Biol Chem. 2010;285(45):35169-79. doi:10.1074/jbc.M110.164475  PMCID:PMC2966130  PMID:20817944 
  32. Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-γ in a nitric oxide-dependent manner. J Immunol. 2010;185(7):4030-41. doi:10.4049/jimmunol.1001778  PMID:20805415 
  33. Characterization of P-Rex1 for its role in fMet-Leu-Phe-induced superoxide production in reconstituted COS(phox) cells. Cell Signal. 2010;22(5):770-82. doi:10.1016/j.cellsig.2010.01.001  PMCID:PMC3282168  PMID:20074642 
  34. Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans. J Clin Invest. 2010;120(3):859-70. doi:10.1172/JCI41443  PMCID:PMC2827964  PMID:20160346 
  35. Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding. J Biol Chem. 2010;285(5):2959-67. doi:10.1074/jbc.M109.030643  PMCID:PMC2823407  PMID:19948736 
  36. Retroviral vector integration in post-transplant hematopoiesis in mice conditioned with either submyeloablative or ablative irradiation. Gene Ther. 2009;16(12):1452-64. doi:10.1038/gt.2009.96  PMCID:PMC2795029  PMID:19657370 
  37. A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40 phox and selective defects in neutrophil NADPH oxidase activity. Blood. 2009;114(15):3309-15. doi:10.1182/blood-2009-07-231498  PMCID:PMC2759653  PMID:19692703 
  38. Activation of antibacterial autophagy by NADPH oxidases. Proc Natl Acad Sci U S A. 2009;106(15):6226-31. doi:10.1073/pnas.0811045106  PMCID:PMC2664152  PMID:19339495 
  39. A fluorescently tagged C-terminal fragment of p47phox detects NADPH oxidase dynamics during phagocytosis. Mol Biol Cell. 2009;20(5):1520-32. doi:10.1091/mbc.E08-06-0620  PMCID:PMC2649267  PMID:19129478 
  40. Suppressed hindlimb perfusion in Rac2-/- and Nox2-/- mice does not result from impaired collateral growth. Am J Physiol Heart Circ Physiol. 2009;296(3):H877-86. doi:10.1152/ajpheart.00772.2008  PMCID:PMC2660231  PMID:19151256 
  41. Macrophage NADPH oxidase flavocytochrome B localizes to the plasma membrane and Rab11-positive recycling endosomes. J Immunol. 2009;182(4):2325-39. doi:10.4049/jimmunol.0803476  PMCID:PMC2666390  PMID:19201887 
  42. Mutational analysis reveals distinct features of the Nox4-p22 phox complex. J Biol Chem. 2008;283(50):35273-82. doi:10.1074/jbc.M804200200  PMCID:PMC2596391  PMID:18849343 
  43. Fc gamma R-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome. Blood. 2008;112(9):3867-77. doi:10.1182/blood-2007-11-126029  PMCID:PMC2572805  PMID:18711001 
  44. Automated analysis of viral integration sites in gene therapy research using the SeqMap web resource. Gene Ther. 2008;15(18):1294-8. doi:10.1038/gt.2008.99  PMCID:PMC2766545  PMID:18580967 
  45. The role of Rac2 in regulating neutrophil production in the bone marrow and circulating neutrophil counts. Am J Pathol. 2008;173(2):507-17. doi:10.2353/ajpath.2008.071059  PMCID:PMC2475787  PMID:18583316 
  46. Neutrophil caveolin-1 expression contributes to mechanism of lung inflammation and injury. Am J Physiol Lung Cell Mol Physiol. 2008;294(2):L178-86. doi:10.1152/ajplung.00263.2007  PMID:17993589 
  47. Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis. Blood. 2007;110(13):4179-87. doi:10.1182/blood-2006-11-057299  PMCID:PMC2234798  PMID:17761833 
  48. Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins. J Immunol. 2007;179(12):8322-31. PMCID:PMC2722108  PMID:18056377 
  49. A critical role of protein kinase C delta activation loop phosphorylation in formyl-methionyl-leucyl-phenylalanine-induced phosphorylation of p47(phox) and rapid activation of nicotinamide adenine dinucleotide phosphate oxidase. J Immunol. 2007;179(11):7720-8. PMID:18025218 
  50. Characterization of a mutation in the Phox homology domain of the NADPH oxidase component p40phox identifies a mechanism for negative regulation of superoxide production. J Biol Chem. 2007;282(41):30273-84. doi:10.1074/jbc.M704416200  PMID:17698849 
  51. Aberrant regulation of hematopoiesis by T cells in BAZF-deficient mice. Mol Cell Biol. 2007;27(15):5275-85. doi:10.1128/MCB.01967-05  PMCID:PMC1952080  PMID:17526724 
  52. SDF-1/CXCL12 enhances in vitro replating capacity of murine and human multipotential and macrophage progenitor cells. Stem Cells Dev. 2007;16(4):589-96. doi:10.1089/scd.2007.0044  PMID:17784832 
  53. Granulocyte colony-stimulating factor prior to nonmyeloablative irradiation decreases murine host hematopoietic stem cell function and increases engraftment of donor marrow cells. Stem Cells. 2007;25(6):1578-85. doi:10.1634/stemcells.2006-0808  PMID:17347493 
  54. Critical roles for p22phox in the structural maturation and subcellular targeting of Nox3. Biochem J. 2007;403(1):97-108. doi:10.1042/BJ20060819  PMCID:PMC1828898  PMID:17140397 
  55. The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity. Mol Cell Biol. 2007;27(1):312-23. doi:10.1128/MCB.00985-06  PMCID:PMC1800642  PMID:17060455 
  56. Deletion mutagenesis of p22phox subunit of flavocytochrome b558: identification of regions critical for gp91phox maturation and NADPH oxidase activity. J Biol Chem. 2006;281(41):30336-46. doi:10.1074/jbc.M607191200  PMID:16895900 
  57. The C-terminal flavin domain of gp91phox bound to plasma membranes of granulocyte-like X-CGD PLB-985 cells is sufficient to anchor cytosolic oxidase components and support NADPH oxidase-associated diaphorase activity independent of cytosolic phospholipase A2 regulation. J Leukoc Biol. 2006;80(3):630-9. doi:10.1189/jlb.1105684  PMID:16844764 
  58. The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis. J Exp Med. 2006;203(8):1915-25. doi:10.1084/jem.20052085  PMCID:PMC2118377  PMID:16880255 
  59. The role of nicotinamide adenine dinucleotide phosphate oxidase-derived reactive oxygen species in the acquisition of metastatic ability of tumor cells. Am J Pathol. 2006;169(1):294-302. doi:10.2353/ajpath.2006.060073  PMCID:PMC1698756  PMID:16816381 
  60. Rac2 concentrations in umbilical cord neutrophils. Biol Neonate. 2006;90(3):156-9. doi:10.1159/000092451  PMID:16582540 
  61. Impaired NADPH oxidase activity in Rac2-deficient murine neutrophils does not result from defective translocation of p47phox and p67phox and can be rescued by exogenous arachidonic acid. J Leukoc Biol. 2006;79(1):223-34. doi:10.1189/jlb.0705371  PMID:16275890 
  62. Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. Cell Signal. 2006;18(1):69-82. doi:10.1016/j.cellsig.2005.03.023  PMID:15927447 
  63. p21-activated kinase (Pak) regulates NADPH oxidase activation in human neutrophils. Blood. 2005;106(12):3962-9. doi:10.1182/blood-2005-03-0859  PMCID:PMC1895105  PMID:16099876 
  64. Gene correction reduces cutaneous inflammation and granuloma formation in murine X-linked chronic granulomatous disease. J Invest Dermatol. 2005;125(4):705-10. doi:10.1111/j.0022-202X.2005.23908.x  PMID:16185269 
  65. Phagocyte-derived reactive oxygen species do not influence the progression of murine blood-stage malaria infections. Infect Immun. 2005;73(8):4941-7. doi:10.1128/IAI.73.8.4941-4947.2005  PMCID:PMC1201219  PMID:16041008 
  66. Newly diagnosed chronic granulomatous disease in a 53-year-old woman with Crohn disease. Ann Allergy Asthma Immunol. 2005;95(2):204-9. doi:10.1016/S1081-1206(10)61212-4  PMID:16136772 
  67. Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways. J Immunol. 2005;174(8):4613-20. PMID:15814684 
  68. Monoclonal antibody CL5 recognizes the amino terminal domain of human phagocyte flavocytochrome b558 large subunit, gp91phox. Eur J Haematol. 2005;74(4):337-47. doi:10.1111/j.1600-0609.2004.00380.x  PMID:15777347 
  69. Unusual polyclonal anti-gp91 peptide antibody interactions with X-linked chronic granulomatous disease-derived human neutrophils are not from compensatory expression of Nox proteins 1, 3, or 4. Eur J Haematol. 2005;74(3):241-9. doi:10.1111/j.1600-0609.2004.00357.x  PMID:15693794 
  70. Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo. Role of the C-terminal polybasic domain. J Biol Chem. 2005;280(2):953-64. doi:10.1074/jbc.M408820200  PMID:15504745 
  71. p40phox: the last NADPH oxidase subunit. Blood Cells Mol Dis. 2005;35(2):291-302. doi:10.1016/j.bcmd.2005.06.010  PMID:16102984 
  72. Reconstitution of chemotactic peptide-induced nicotinamide adenine dinucleotide phosphate (reduced) oxidase activation in transgenic COS-phox cells. J Immunol. 2004;173(12):7462-70. PMID:15585872 
  73. Site-specific inhibitors of NADPH oxidase activity and structural probes of flavocytochrome b: characterization of six monoclonal antibodies to the p22phox subunit. J Immunol. 2004;173(12):7349-57. PMID:15585859 
  74. A murine model of antimetabolite-based, submyeloablative conditioning for bone marrow transplantation: biologic insights and potential applications. Exp Hematol. 2004;32(12):1255-64. doi:10.1016/j.exphem.2004.08.007  PMID:15588950 
  75. Rac2-deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles. J Immunol. 2004;173(10):5971-9. PMID:15528331 
  76. Mitochondrial transmembrane potential is diminished in phorbol myristate acetate-stimulated peritoneal resident macrophages isolated from wild-type mice, but not in those from gp91-phox-deficient mice. Histochem Cell Biol. 2004;122(4):323-32. doi:10.1007/s00418-004-0674-0  PMID:15243751 
  77. In vivo role of myeloperoxidase for the host defense. Jpn J Infect Dis. 2004;57(5):S15. PMID:15507755 
  78. [Expression and activity of polymorphisms in the 67-kDa protein of the NADPH oxidase system]. Biomedica. 2004;24(3):262-72. PMID:15551878 
  79. Rac2 is critical for neutrophil primary granule exocytosis. Blood. 2004;104(3):832-9. doi:10.1182/blood-2003-07-2624  PMID:15073033 
  80. Antagonistic cross-talk between Rac and Cdc42 GTPases regulates generation of reactive oxygen species. J Biol Chem. 2004;279(27):28136-42. doi:10.1074/jbc.M313891200  PMID:15123662 
  81. Stable long-term gene correction with low-dose radiation conditioning in murine X-linked chronic granulomatous disease. Blood Cells Mol Dis. 2004;33(3):365-71. doi:10.1016/j.bcmd.2004.06.007  PMID:15528159 
  82. The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl-leucyl-phenylalanine-activated neutrophil functions. J Immunol. 2003;171(8):4425-30. PMID:14530369 
  83. Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions. J Immunol. 2003;170(11):5652-7. PMID:12759446 
  84. Long-term high-level reconstitution of NADPH oxidase activity in murine X-linked chronic granulomatous disease using a bicistronic vector expressing gp91phox and a Delta LNGFR cell surface marker. Hum Gene Ther. 2003;14(7):651-66. doi:10.1089/104303403321618164  PMID:12804147 
  85. Safety of retroviral gene marking with a truncated NGF receptor. Nat Med. 2003;9(4):367-9. doi:10.1038/nm0403-367  PMID:12669036 
  86. Regulation of neutrophil function by Rac GTPases. Curr Opin Hematol. 2003;10(1):8-15. PMID:12483106 
  87. Relative contributions of myeloperoxidase and NADPH-oxidase to the early host defense against pulmonary infections with Candida albicans and Aspergillus fumigatus. Med Mycol. 2002;40(6):557-63. PMID:12521119 
  88. Retroviral-mediated gene transfer and nonmyeloablative conditioning: studies in a murine X-linked chronic granulomatous disease model. J Pediatr Hematol Oncol. 2002;24(9):787-90. PMID:12468930 
  89. Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions. J Immunol. 2002;169(9):5043-51. PMID:12391220 
  90. Donor chimerism and stem cell function in a murine congenic transplantation model after low-dose radiation conditioning: effects of a retroviral-mediated gene transfer protocol and implications for gene therapy. Exp Hematol. 2002;30(11):1324-32. PMID:12423686 
  91. Mutagenesis of p22(phox) histidine 94. A histidine in this position is not required for flavocytochrome b558 function. J Biol Chem. 2002;277(33):30368-74. doi:10.1074/jbc.M203993200  PMID:12042318 
  92. Critical role of myeloperoxidase and nicotinamide adenine dinucleotide phosphate-oxidase in high-burden systemic infection of mice with Candida albicans. J Infect Dis. 2002;185(12):1833-7. doi:10.1086/340635  PMID:12085336 
  93. Absence of proton channels in COS-7 cells expressing functional NADPH oxidase components. J Gen Physiol. 2002;119(6):571-80. PMCID:PMC2233867  PMID:12034764 
  94. Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent. J Biol Chem. 2002;277(21):19220-8. doi:10.1074/jbc.M200061200  PMID:11896053 
  95. Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by Gram-negative sepsis: studies in p47phox-/- and gp91phox-/- mice. J Immunol. 2002;168(8):3974-82. PMID:11937554 
  96. Creation of a genetic system for analysis of the phagocyte respiratory burst: high-level reconstitution of the NADPH oxidase in a nonhematopoietic system. Blood. 2002;99(8):2653-61. PMID:11929750 
  97. Enhanced cutaneous inflammatory reactions to Aspergillus fumigatus in a murine model of chronic granulomatous disease. J Invest Dermatol. 2002;118(3):424-9. doi:10.1046/j.0022-202x.2001.01691.x  PMID:11874480 
  98. Evidence for the involvement of the NADPH oxidase enzyme complex in the optimal accumulation of Platelet-activating factor in the human cell line PLB-985. Prostaglandins Other Lipid Mediat. 2001;66(4):305-15. PMID:11785782 
  99. The gp91phox component of NADPH oxidase is not the voltage-gated proton channel in phagocytes, but it helps. J Biol Chem. 2001;276(39):36063-6. doi:10.1074/jbc.C100352200  PMID:11477065 
  100. Heme-ligating histidines in flavocytochrome b(558): identification of specific histidines in gp91(phox). J Biol Chem. 2001;276(33):31105-12. doi:10.1074/jbc.M103327200  PMID:11413138 
  101. Variable correction of host defense following gene transfer and bone marrow transplantation in murine X-linked chronic granulomatous disease. Blood. 2001;97(12):3738-45. PMID:11389011 
  102. Phage display epitope mapping of human neutrophil flavocytochrome b558. Identification of two juxtaposed extracellular domains. J Biol Chem. 2001;276(3):2053-61. doi:10.1074/jbc.M006236200  PMID:11027685 
  103. Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways. J Immunol. 2001;166(2):1223-32. PMID:11145705 
  104. Targeted inhibition of the small GTPase protects against ischemia/reperfusion liver injury in mice. Transplant Proc. 2001;33(1-2):863-4. PMID:11267105 
  105. Phagocyte-derived reactive oxygen species and the immunology and pathology of murine malaria. Redox Rep. 2001;6(3):200-3. doi:10.1179/135100001101536210  PMID:11523600 
  106. Location of the epitope for 7D5, a monoclonal antibody raised against human flavocytochrome b558, to the extracellular peptide portion of primate gp91phox. Microbiol Immunol. 2001;45(3):249-57. PMID:11345535 
  107. The intracellular oxidation of 2',7'-dichlorofluorescin in murine T lymphocytes. Free Radic Biol Med. 2001;30(1):82-8. PMID:11134898 
  108. Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency. Blood. 2000;96(5):1646-54. PMID:10961859 
  109. Mechanisms of NSAID-induced gastrointestinal injury defined using mutant mice. Gastroenterology. 2000;119(3):699-705. PMID:10982764 
  110. Impaired superoxide production due to a deficiency in phagocyte NADPH oxidase fails to inhibit atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 2000;20(6):1529-35. PMID:10845868 
  111. Processing and maturation of flavocytochrome b558 include incorporation of heme as a prerequisite for heterodimer assembly. J Biol Chem. 2000;275(18):13986-93. PMID:10788525 
  112. Gene therapy of chronic granulomatous disease. Bone Marrow Transplant. 2000;25 Suppl 2:S99-104. PMID:10933200 
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