R. Mark Grady, M.D.  rmgrady@wustl.edu

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Associate Professor of Pediatrics, Cardiology
Cardiology

phone: (314) 454-6095

Education

  • BA, Princeton University1984
  • MD, Washington University School of Medicine1989
  • MA, Washington University School of Medicine1989

Training

  • Residency, St. Louis Children's Hospital, Washington University School of Medicine1989 - 1992
  • Fellow, Washington University School of Medicine, St. Louis Children's Hospital1992 - 1997

Licensure and Board Certification

  • MO, 1997
  • American Board of Pediatrics, certificate number 1377 1998
  • American Board of Pediatrics, Subboard of Pediatric Cardiology, certificate number 001377 2005
  • IL, 2011
  • MO, DEA 2011
  • MO, BNDD 2012

Honors

  • Princeton University: Phi Beta kappa--Academic honor society
  • Princeton University: Senior book prize for excellence in scholarship
  • Princeton University: Sigma Xi--Scientific research honor society
  • Princeton University: Summa cum laude graduate
  • Washington University: Alpha Omege Alpha--Medical honor society
  • Washington University: Merck manual award for oustanding medical student
  • Washington University: Recipient of the 1999 Richard D. Rowe award for research in pediatric cardiology given by the Society for Pediatric Research

Recent Publications view all (35)


  1. Treatment of Pulmonary Hypertension Curr Treat Options Cardiovasc Med. 2018;20(8). PMID:29464391 
  2. Pulmonary Arterivenous Malformations in Children with Hereditary Hemorrhagic Telangiectasia: A Longitudinal Study Pulm Circ. 2018;8(3). 
  3. Infants with Atypical Presentations of Alveolar Capillary Dysplasia with Misalignment of the Pulmonary Veins Who underwent Bilateral Lung Transplantation J Pediatr. 2017;194:158-64. PMID:29198536 
  4. Glucocorticoids for treating paediatric pulmonary hypertension: a novel use for a common medication Cardiol Young. 2017;16:1-3. PMID:28506331 
  5. Pulmonary artery acceleration time provides a reliable estimate of invasive pulmonary hemodynamics in children J Am Soc Echocardiogr. 2017;29(11):1056-1065. PMID:27641101 
  6. Isolated Major Aortopulmonary Collateral as the Sole Pulmonary Blood Supply to an Entire Lung Segment Case Rep Cardiol. 2017;2017:3 pages. PMID:28785488 
  7. Potts Shunt and Pediatric Pulmonary Hypertension: What We Have Learned. Ann Thorac Surg. 2016;101(4):1539-43. PMID:26518375 
  8. Recommendations for utilization of the paracorporeal lung assist device in neonates and young children with pulmonary hypertension. Pediatr Transplant. 2016;20(2):256-70. PMID:26899454 
  9. Α-Dystrobrevin-1 recruits Grb2 and α-catulin to organize neurotransmitter receptors at the neuromuscular junction. J Cell Sci. 2016;129(5):898-911. PMCID:PMC4813319  PMID:26769899 
  10. Two deletions overlapping a distant FOXF1 enhancer unravel the role of lncRNA LINC01081 in etiology of alveolar capillary dysplasia with misalignment of pulmonary veins. Am J Med Genet A. 2014. doi:10.1002/ajmg.a.36606  PMID:24842713 
  11. Paracorporeal lung assist devices as a bridge to recovery or lung transplantation in neonates and young children. J Thorac Cardiovasc Surg. 2014;147(1):420-6. doi:10.1016/j.jtcvs.2013.08.078  PMID:24199759 
  12. Molecular and phenotypic characterization of atypical Williams-Beuren syndrome. Clin Genet. 2013. doi:10.1111/cge.12305  PMID:24246242 
  13. Neonatal paracorporeal lung assist device for respiratory failure. Ann Thorac Surg. 2013;95(2):692-4. doi:10.1016/j.athoracsur.2012.05.128  PMID:23336880 
  14. Noncardiac chest pain in children and adolescents: a biopsychosocial conceptualization. Child Psychiatry Hum Dev. 2012;43(1):1-26. doi:10.1007/s10578-011-0240-7  PMID:21701910 
  15. Lung transplantation in children with idiopathic pulmonary arterial hypertension: an 18-year experience. J Heart Lung Transplant. 2011;30(10):1148-52. doi:10.1016/j.healun.2011.04.009  PMID:21620736 
  16. First experience with a paracorporeal artificial lung in a small child with pulmonary hypertension. J Thorac Cardiovasc Surg. 2011;141(6):e48-50. doi:10.1016/j.jtcvs.2011.02.005  PMID:21420104 
  17. Dismal lung transplant outcomes in children with tetralogy of Fallot with pulmonary atresia compared to Eisenmenger syndrome or pulmonary vein stenosis. J Heart Lung Transplant. 2009;28(11):1221-5. doi:10.1016/j.healun.2009.07.010  PMID:19783168 
  18. Beyond Berlin: heart transplantation in the "untransplantable". J Thorac Cardiovasc Surg. 2008;136(2):529-31. doi:10.1016/j.jtcvs.2008.01.032  PMID:18692672 
  19. Cerebellar synaptic defects and abnormal motor behavior in mice lacking alpha- and beta-dystrobrevin. J Neurosci. 2006;26(11):2841-51. doi:10.1523/JNEUROSCI.4823-05.2006  PMID:16540561 
  20. Syne proteins anchor muscle nuclei at the neuromuscular junction. Proc Natl Acad Sci U S A. 2005;102(12):4359-64. doi:10.1073/pnas.0500711102  PMCID:PMC555524  PMID:15749817 
  21. Tyrosine-phosphorylated and nonphosphorylated isoforms of alpha-dystrobrevin: roles in skeletal muscle and its neuromuscular and myotendinous junctions. J Cell Biol. 2003;160(5):741-52. doi:10.1083/jcb.200209045  PMCID:PMC2173352  PMID:12604589 
  22. Neurotransmitter receptor dynamics studied in vivo by reversible photo-unbinding of fluorescent ligands. Neuron. 2002;34(6):865-76. PMID:12086635 
  23. Dystroglycan is selectively associated with inhibitory GABAergic synapses but is dispensable for their differentiation. J Neurosci. 2002;22(11):4274-85. doi:20026440  PMID:12040032 
  24. Increased vulnerability to kainate-induced seizures in utrophin-knockout mice. Eur J Neurosci. 2002;15(9):1474-84. PMID:12028357 
  25. Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction. J Biol Chem. 2000;275(41):31986-95. doi:10.1074/jbc.M004775200  PMID:10878022 
  26. Maturation and maintenance of the neuromuscular synapse: genetic evidence for roles of the dystrophin--glycoprotein complex. Neuron. 2000;25(2):279-93. PMID:10719885 
  27. Role for alpha-dystrobrevin in the pathogenesis of dystrophin-dependent muscular dystrophies. Nat Cell Biol. 1999;1(4):215-20. doi:10.1038/12034  PMID:10559919 
  28. Membrane targeting and stabilization of sarcospan is mediated by the sarcoglycan subcomplex. J Cell Biol. 1999;145(1):153-65. PMCID:PMC2148225  PMID:10189375 
  29. Agrin receptors at the skeletal neuromuscular junction Ann N Y Acad Sci. 1998;841:1-13. PMID:9668217 
  30. Development of the neuromuscular junction: genetic analysis in mice. J Physiol Paris. 1998;92(3-4):167-72. PMID:9789802 
  31. Differential membrane localization and intermolecular associations of alpha-dystrobrevin isoforms in skeletal muscle Journal of Cell Biology. 1998;142:1269-1278. 
  32. Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophy. Cell. 1997;90(4):729-38. PMID:9288752 
  33. Subtle neuromuscular defects in utrophin-deficient mice. J Cell Biol. 1997;136(4):871-82. PMCID:PMC2132496  PMID:9049252 
  34. Rational approach to use of heparin during cardiac catheterization in children. J Am Coll Cardiol. 1995;25(3):725-9. doi:10.1016/0735-1097(94)00438-V  PMID:7860920 
  35. Transcatheter coil embolisation of a pulmonary arteriovenous malformation in a neonate. Br Heart J. 1994;71(4):370-1. PMCID:PMC483690  PMID:8198890 
Last updated: 07/31/2018
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