Department of Pediatrics
Toggle navigation
Home
Residency
Education
PSRP
Educational Programs
Weekly Schedule
Fellow Core Curriculum
Fellowships
Allergy & Pulmonary Medicine
Cardiology
Child Abuse Pediatrics
Clinical Informatics
Critical Care Medicine
Emergency Medicine
Endocrinology & Diabetes
Fellowship Training Grants
Gastroenterology, Hepatology & Nutrition
Genetics & Genomic Medicine
Hematology & Oncology
Hospice & Palliative Medicine
Hospital Medicine
Infectious Diseases
Nephrology, Hypertension & Pheresis
Newborn Medicine
Rheumatology & Immunology
Fellow Core Curriculum
Divisions
Academic Pediatrics
Adolescent Medicine
Allergy & Pulmonary Medicine
Cardiology
Critical Care Medicine
Emergency Medicine
Endocrinology & Diabetes
Gastroenterology, Hepatology & Nutrition
Genetics & Genomic Medicine
Hematology & Oncology
Hospital Medicine
Infectious Diseases
Nephrology, Hypertension & Pheresis
Newborn Medicine
Rheumatology & Immunology
Other Services
Research
Patient Care
Patient Care Home
Adolescent Medicine
Allergy & Pulmonary Medicine
Cardiology
Critical Care Medicine
Emergency Medicine
Endocrinology & Diabetes
Gastroenterology, Hepatology & Nutrition
Genetics & Genomic Medicine
Hematology & Oncology
Hospital Medicine
Infectious Diseases
Nephrology, Hypertension & Pheresis
Newborn Medicine
Rheumatology & Immunology
Phone Numbers
Office Locations
Virtual Tours
Faculty
Newsletter
R. Mark Grady, M.D.
rmgrady@wustl.edu
Professor of Pediatrics, Cardiology
Cardiology
phone: (314) 454-6095
Education
BA,
Princeton University
,
1984
MD,
Washington University School of Medicine
,
1989
MA,
Washington University School of Medicine
,
1989
Training
Residency, St. Louis Children's Hospital, Washington University School of Medicine
,
1989
-
1992
Fellow, Washington University School of Medicine, St. Louis Children's Hospital
,
1992
-
1997
Licensure and Board Certification
1997
-
Pres
MO
1998
-
2008
American Board of Pediatrics, certificate number 1377
2005
-
Pres
American Board of Pediatrics, Subboard of Pediatric Cardiology, certificate number 001377
2011
-
Pres
IL
2011
-
Pres
MO, DEA
2012
-
Pres
MO, BNDD
Honors and Awards
Princeton University: Phi Beta kappa--Academic honor society
Princeton University: Senior book prize for excellence in scholarship
Princeton University: Sigma Xi--Scientific research honor society
Princeton University: Summa cum laude graduate
Washington University: Alpha Omege Alpha--Medical honor society
Washington University: Merck manual award for oustanding medical student
Washington University: Recipient of the 1999 Richard D. Rowe award for research in pediatric cardiology given by the Society for Pediatric Research
Recent Publications
view all (41)
Publication Co-Authors
Stuart C. Sweet, M.D., Ph.D.
Marwan Shinawi, M.D.
Lisa M. Moscoso, M.D., Ph.D.
Georgeann Groh, M.D.
Laura Schuettpelz, M.D, Ph.D.
Jennifer A Wambach, M.D.
Charles Canter, M.D.
Manish Aggarwal
David Balzer, M.D.
Avihu Z. Gazit, M.D.
Francis Sessions Cole, III, M.D.
Symersky P, Jansen SMA, Kamminga SK, Meijboom LJ, Lust EJ, Eghtesady P, Grady RM, Bogaard HJ.
Improvement in exercise capacity after a modified Potts shunt in an adult patient with pulmonary arterial hypertension.
ERJ Open Res
.
2021;7
(4).
PMCID:
PMC8488222
PMID:
34616835
Grady RM, Canter MW, Wan F, Shmalts AA, Coleman RD, Beghetti M, Berger RMF, Del Cerro Marin MJ, Fletcher SE, Hirsch R, Humpl T, Ivy DD, Kirkpatrick EC, Kulik TJ, Levy M, Moledina S, Yung D, Eghtesady P, Bonnet D, International Registry Potts Shunt..
Pulmonary-to-Systemic Arterial Shunt to Treat Children With Severe Pulmonary Hypertension.
J Am Coll Cardiol
.
2021;78
(5):
468-477.
PMID:
34325836
Lancaster TS, Shahanavaz S, Balzer DT, Sweet SC, Grady RM, Eghtesady P.
Midterm outcomes of the Potts shunt for pediatric pulmonary hypertension, with comparison to lung transplant.
J Thorac Cardiovasc Surg
.
2021;161
(3):
1139-1148.
PMID:
33454101
R Mark Grady.
Beyond transplant: Roles of atrial septostomy and Potts shunt in pediatric pulmonary hypertension
Pediatr Pulmonol
.
2020.
doi:
10.1002/ppul.25049
PMID:
32860488
Aggarwal M, Schuettpelz L, Kolodziej J, Grady RM.
Rapid development of pulmonary hypertension during treatment of paediatric cancer.
Cardiol Young
.
2019;29
(3):
286-289.
doi:
10.1017/S1047951118002196
PMID:
30678742
Aggarwal M, Grady RM, Choudhry S, Anwar S, Eghtesady P, Singh GK.
Potts shunt improves right ventricular function and coupling with pulmonary circulation in children with suprasystemic pulmonary arterial hypertension
circ cardiovasc imaging
.
2018;11
(12).
PMID:
30558504
Aggarwal M, Grady RM.
Treatment of Pulmonary Hypertension
Curr Treat Options Cardiovasc Med
.
2018;20
(8).
PMID:
29464391
Mowers KL, Sekarski L, White AJ, Grady RM.
Pulmonary Arterivenous Malformations in Children with Hereditary Hemorrhagic Telangiectasia: A Longitudinal Study
Pulm Circ
.
2018;8
(3).
Towe CT, White FV, Grady RM, Sweet SC, Eghtesady P, Wegner DJ, Sen P, Szafranski P, Hamvas A, Cole FS, Wambach JA.
Infants with Atypical Presentations of Alveolar Capillary Dysplasia with Misalignment of the Pulmonary Veins Who underwent Bilateral Lung Transplantation
J Pediatr
.
2017;194:158-64.
PMID:
29198536
Aggarwal M, Grady RM.
Glucocorticoids for treating paediatric pulmonary hypertension: a novel use for a common medication
Cardiol Young
.
2017;16:1-3.
PMID:
28506331
Levy PT, Patel MD, Grog G, Choudry S, Murphy J, Holland MR, Hamvas A, Grady RM, Singh GK.
Pulmonary artery acceleration time provides a reliable estimate of invasive pulmonary hemodynamics in children
J Am Soc Echocardiogr
.
2017;29
(11):
1056-1065.
PMID:
27641101
Kim HS, Grady RM, Shahanavaz S.
Isolated Major Aortopulmonary Collateral as the Sole Pulmonary Blood Supply to an Entire Lung Segment
Case Rep Cardiol
.
2017;2017:3 pages.
PMID:
28785488
Grady RM, Eghtesady P.
Potts Shunt and Pediatric Pulmonary Hypertension: What We Have Learned.
Ann Thorac Surg
.
2016;101
(4):
1539-43.
PMID:
26518375
Gazit AZ, Sweet SC, Grady RM, Boston US, Huddleston CB, Hoganson DM, Shepard M, Raithel S, Mehegan M, Doctor A, Spinella PC, Eghtesady P.
Recommendations for utilization of the paracorporeal lung assist device in neonates and young children with pulmonary hypertension.
Pediatr Transplant
.
2016;20
(2):
256-70.
PMID:
26899454
Gingras J, Gawor M, Bernadzki KM, Grady RM, Hallock P, Glass DJ, Sanes JR, Proszynski TJ.
Α-Dystrobrevin-1 recruits Grb2 and α-catulin to organize neurotransmitter receptors at the neuromuscular junction.
J Cell Sci
.
2016;129
(5):
898-911.
PMCID:
PMC4813319
PMID:
26769899
Szafranski P, Dharmadhikari AV, Wambach JA, Towe CT, White FV, Grady RM, Eghtesady P, Cole FS, Deutsch G, Sen P, Stankiewicz P.
Two deletions overlapping a distant FOXF1 enhancer unravel the role of lncRNA LINC01081 in etiology of alveolar capillary dysplasia with misalignment of pulmonary veins.
Am J Med Genet A
.
2014.
doi:
10.1002/ajmg.a.36606
PMID:
24842713
Hoganson DM, Gazit AZ, Boston US, Sweet SC, Grady RM, Huddleston CB, Eghtesady P.
Paracorporeal lung assist devices as a bridge to recovery or lung transplantation in neonates and young children.
J Thorac Cardiovasc Surg
.
2014;147
(1):
420-6.
doi:
10.1016/j.jtcvs.2013.08.078
PMID:
24199759
Euteneuer J, Carvalho CM, Kulkarni S, Vineyard M, Grady RM, Lupski JR, Shinawi M.
Molecular and phenotypic characterization of atypical Williams-Beuren syndrome.
Clin Genet
.
2013.
doi:
10.1111/cge.12305
PMID:
24246242
Hoganson DM, Gazit AZ, Sweet SC, Grady RM, Huddleston CB, Eghtesady P.
Neonatal paracorporeal lung assist device for respiratory failure.
Ann Thorac Surg
.
2013;95
(2):
692-4.
doi:
10.1016/j.athoracsur.2012.05.128
PMID:
23336880
McDonnell CJ, White KS, Grady RM.
Noncardiac chest pain in children and adolescents: a biopsychosocial conceptualization.
Child Psychiatry Hum Dev
.
2012;43
(1):
1-26.
doi:
10.1007/s10578-011-0240-7
PMID:
21701910
Goldstein BS, Sweet SC, Mao J, Huddleston CB, Grady RM.
Lung transplantation in children with idiopathic pulmonary arterial hypertension: an 18-year experience.
J Heart Lung Transplant
.
2011;30
(10):
1148-52.
doi:
10.1016/j.healun.2011.04.009
PMID:
21620736
Gazit AZ, Sweet SC, Grady RM, Huddleston CB.
First experience with a paracorporeal artificial lung in a small child with pulmonary hypertension.
J Thorac Cardiovasc Surg
.
2011;141
(6):
e48-50.
doi:
10.1016/j.jtcvs.2011.02.005
PMID:
21420104
Grady RM, Gandhi S, Sweet SC, Mao J, Huddleston CB.
Dismal lung transplant outcomes in children with tetralogy of Fallot with pulmonary atresia compared to Eisenmenger syndrome or pulmonary vein stenosis.
J Heart Lung Transplant
.
2009;28
(11):
1221-5.
doi:
10.1016/j.healun.2009.07.010
PMID:
19783168
Gandhi SK, Grady RM, Huddleston CB, Balzer DT, Canter CE.
Beyond Berlin: heart transplantation in the "untransplantable".
J Thorac Cardiovasc Surg
.
2008;136
(2):
529-31.
doi:
10.1016/j.jtcvs.2008.01.032
PMID:
18692672
Grady RM, Wozniak DF, Ohlemiller KK, Sanes JR.
Cerebellar synaptic defects and abnormal motor behavior in mice lacking alpha- and beta-dystrobrevin.
J Neurosci
.
2006;26
(11):
2841-51.
doi:
10.1523/JNEUROSCI.4823-05.2006
PMID:
16540561
Grady RM, Starr DA, Ackerman GL, Sanes JR, Han M.
Syne proteins anchor muscle nuclei at the neuromuscular junction.
Proc Natl Acad Sci U S A
.
2005;102
(12):
4359-64.
doi:
10.1073/pnas.0500711102
PMCID:
PMC555524
PMID:
15749817
Grady RM, Akaaboune M, Cohen AL, Maimone MM, Lichtman JW, Sanes JR.
Tyrosine-phosphorylated and nonphosphorylated isoforms of alpha-dystrobrevin: roles in skeletal muscle and its neuromuscular and myotendinous junctions.
J Cell Biol
.
2003;160
(5):
741-52.
doi:
10.1083/jcb.200209045
PMCID:
PMC2173352
PMID:
12604589
Akaaboune M, Grady RM, Turney S, Sanes JR, Lichtman JW.
Neurotransmitter receptor dynamics studied in vivo by reversible photo-unbinding of fluorescent ligands.
Neuron
.
2002;34
(6):
865-76.
PMID:
12086635
Lévi S, Grady RM, Henry MD, Campbell KP, Sanes JR, Craig AM.
Dystroglycan is selectively associated with inhibitory GABAergic synapses but is dispensable for their differentiation.
J Neurosci
.
2002;22
(11):
4274-85.
doi:
20026440
PMID:
12040032
Knuesel I, Riban V, Zuellig RA, Schaub MC, Grady RM, Sanes JR, Fritschy JM.
Increased vulnerability to kainate-induced seizures in utrophin-knockout mice.
Eur J Neurosci
.
2002;15
(9):
1474-84.
PMID:
12028357
Apel ED, Lewis RM, Grady RM, Sanes JR.
Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.
J Biol Chem
.
2000;275
(41):
31986-95.
doi:
10.1074/jbc.M004775200
PMID:
10878022
Grady RM, Zhou H, Cunningham JM, Henry MD, Campbell KP, Sanes JR.
Maturation and maintenance of the neuromuscular synapse: genetic evidence for roles of the dystrophin--glycoprotein complex.
Neuron
.
2000;25
(2):
279-93.
PMID:
10719885
Grady RM, Grange RW, Lau KS, Maimone MM, Nichol MC, Stull JT, Sanes JR.
Role for alpha-dystrobrevin in the pathogenesis of dystrophin-dependent muscular dystrophies.
Nat Cell Biol
.
1999;1
(4):
215-20.
doi:
10.1038/12034
PMID:
10559919
Crosbie RH, Lebakken CS, Holt KH, Venzke DP, Straub V, Lee JC, Grady RM, Chamberlain JS, Sanes JR, Campbell KP.
Membrane targeting and stabilization of sarcospan is mediated by the sarcoglycan subcomplex.
J Cell Biol
.
1999;145
(1):
153-65.
PMCID:
PMC2148225
PMID:
10189375
Sanes JR, Apel ED, Gautam M, Glass D, Grady RM, Martin PT, Nichol MC, Yancopoulos GD.
Agrin receptors at the skeletal neuromuscular junction
Ann N Y Acad Sci
.
1998;841:1-13.
PMID:
9668217
Sanes JR, Apel ED, Burgess RW, Emerson RB, Feng G, Gautam M, Glass D, Grady RM, Krejci E, Lichtman JW, Lu JT, Massoulié J, Miner JH, Moscoso LM, Nguyen Q, Nichol M, Noakes PG, Patton BL, Son YJ, Yancopoulos GD, Zhou H.
Development of the neuromuscular junction: genetic analysis in mice.
J Physiol Paris
.
1998;92
(3-4):
167-72.
PMID:
9789802
Peters MF, Sadoulet-Puccio HM, Grady RM, Kramarcy NR, Kunkel LM, Sanes JR, Sealock R, Froehner.
Differential membrane localization and intermolecular associations of alpha-dystrobrevin isoforms in skeletal muscle
Journal of Cell Biology
.
1998;142:1269-1278.
Grady RM, Teng H, Nichol MC, Cunningham JC, Wilkinson RS, Sanes JR.
Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophy.
Cell
.
1997;90
(4):
729-38.
PMID:
9288752
Grady RM, Merlie JP, Sanes JR.
Subtle neuromuscular defects in utrophin-deficient mice.
J Cell Biol
.
1997;136
(4):
871-82.
PMCID:
PMC2132496
PMID:
9049252
Grady RM, Eisenberg PR, Bridges ND.
Rational approach to use of heparin during cardiac catheterization in children.
J Am Coll Cardiol
.
1995;25
(3):
725-9.
doi:
10.1016/0735-1097(94)00438-V
PMID:
7860920
Grady RM, Sharkey AM, Bridges ND.
Transcatheter coil embolisation of a pulmonary arteriovenous malformation in a neonate.
Br Heart J
.
1994;71
(4):
370-1.
PMCID:
PMC483690
PMID:
8198890
Last updated: 11/09/2021
Internal Links
Office 365
External Citrix
Internal ECV
External ECV
HRMS
Pediatric Intranet
Faculty Opportunities
Office of Faculty Development
Login
Affiliates
St. Louis Children’s Hospital
Barnes-Jewish Hospital
BJC Healthcare
Children’s Discovery Institute
IT Services
Helpdesk
PCF Home
Clinical Informatics
Follow Us
Find a Physician
Make a Gift
© 2022 by Washington University in St. Louis
One Brookings Drive, St. Louis, MO 63130