Department of Pediatrics

Education

• BA, Princeton University, 1984
• MD, Washington University School of Medicine, 1989
• MA, Washington University School of Medicine, 1989

Training

• Residency, St. Louis Children's Hospital, Washington University School of Medicine, 1989 - 1992
• Fellow, Washington University School of Medicine, St. Louis Children's Hospital, 1992 - 1997

Licensure and Board Certification

• 1997 - PresMO
• 1998 - 2008American Board of Pediatrics, certificate number 1377
• 2005 - PresAmerican Board of Pediatrics, Subboard of Pediatric Cardiology, certificate number 001377
• 2011 - PresIL
• 2011 - PresMO, DEA
• 2012 - PresMO, BNDD

Honors and Awards

• Princeton University: Phi Beta kappa--Academic honor society
• Princeton University: Senior book prize for excellence in scholarship
• Princeton University: Sigma Xi--Scientific research honor society
• Princeton University: Summa cum laude graduate
• Washington University: Alpha Omege Alpha--Medical honor society
• Washington University: Merck manual award for oustanding medical student
• Washington University: Recipient of the 1999 Richard D. Rowe award for research in pediatric cardiology given by the Society for Pediatric Research

Recent Publications view all (41)

Publication Co-Authors

Stuart C. Sweet, M.D., Ph.D.

Marwan Shinawi, M.D.

Lisa M. Moscoso, M.D., Ph.D.

Georgeann Groh, M.D.

Laura Schuettpelz, M.D, Ph.D.

Jennifer A Wambach, M.D.

Charles Canter, M.D.

Manish Aggarwal

David Balzer, M.D.

Avihu Z. Gazit, M.D.

Francis Sessions Cole, III, M.D.

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with R. Mark Grady, M.D.

1. Symersky P, Jansen SMA, Kamminga SK, Meijboom LJ, Lust EJ, Eghtesady P, Grady RM, Bogaard HJ. Improvement in exercise capacity after a modified Potts shunt in an adult patient with pulmonary arterial hypertension. ERJ Open Res. 2021;7(4). PMCID:PMC8488222  PMID:34616835 
2. Grady RM, Canter MW, Wan F, Shmalts AA, Coleman RD, Beghetti M, Berger RMF, Del Cerro Marin MJ, Fletcher SE, Hirsch R, Humpl T, Ivy DD, Kirkpatrick EC, Kulik TJ, Levy M, Moledina S, Yung D, Eghtesady P, Bonnet D, International Registry Potts Shunt.. Pulmonary-to-Systemic Arterial Shunt to Treat Children With Severe Pulmonary Hypertension. J Am Coll Cardiol. 2021;78(5):468-477. PMID:34325836 
3. Lancaster TS, Shahanavaz S, Balzer DT, Sweet SC, Grady RM, Eghtesady P. Midterm outcomes of the Potts shunt for pediatric pulmonary hypertension, with comparison to lung transplant. J Thorac Cardiovasc Surg. 2021;161(3):1139-1148. PMID:33454101 
4. R Mark Grady. Beyond transplant: Roles of atrial septostomy and Potts shunt in pediatric pulmonary hypertension Pediatr Pulmonol. 2020. doi:10.1002/ppul.25049  PMID:32860488 
5. Aggarwal M, Schuettpelz L, Kolodziej J, Grady RM. Rapid development of pulmonary hypertension during treatment of paediatric cancer. Cardiol Young. 2019;29(3):286-289. doi:10.1017/S1047951118002196  PMID:30678742 
6. Aggarwal M, Grady RM, Choudhry S, Anwar S, Eghtesady P, Singh GK. Potts shunt improves right ventricular function and coupling with pulmonary circulation in children with suprasystemic pulmonary arterial hypertension circ cardiovasc imaging. 2018;11(12). PMID:30558504 
7. Aggarwal M, Grady RM. Treatment of Pulmonary Hypertension Curr Treat Options Cardiovasc Med. 2018;20(8). PMID:29464391 
8. Mowers KL, Sekarski L, White AJ, Grady RM. Pulmonary Arterivenous Malformations in Children with Hereditary Hemorrhagic Telangiectasia: A Longitudinal Study Pulm Circ. 2018;8(3). 
9. Towe CT, White FV, Grady RM, Sweet SC, Eghtesady P, Wegner DJ, Sen P, Szafranski P, Hamvas A, Cole FS, Wambach JA. Infants with Atypical Presentations of Alveolar Capillary Dysplasia with Misalignment of the Pulmonary Veins Who underwent Bilateral Lung Transplantation J Pediatr. 2017;194:158-64. PMID:29198536 
10. Aggarwal M, Grady RM. Glucocorticoids for treating paediatric pulmonary hypertension: a novel use for a common medication Cardiol Young. 2017;16:1-3. PMID:28506331 
11. Levy PT, Patel MD, Grog G, Choudry S, Murphy J, Holland MR, Hamvas A, Grady RM, Singh GK. Pulmonary artery acceleration time provides a reliable estimate of invasive pulmonary hemodynamics in children J Am Soc Echocardiogr. 2017;29(11):1056-1065. PMID:27641101 
12. Kim HS, Grady RM, Shahanavaz S. Isolated Major Aortopulmonary Collateral as the Sole Pulmonary Blood Supply to an Entire Lung Segment Case Rep Cardiol. 2017;2017:3 pages. PMID:28785488 
13. Grady RM, Eghtesady P. Potts Shunt and Pediatric Pulmonary Hypertension: What We Have Learned. Ann Thorac Surg. 2016;101(4):1539-43. PMID:26518375 
14. Gazit AZ, Sweet SC, Grady RM, Boston US, Huddleston CB, Hoganson DM, Shepard M, Raithel S, Mehegan M, Doctor A, Spinella PC, Eghtesady P. Recommendations for utilization of the paracorporeal lung assist device in neonates and young children with pulmonary hypertension. Pediatr Transplant. 2016;20(2):256-70. PMID:26899454 
15. Gingras J, Gawor M, Bernadzki KM, Grady RM, Hallock P, Glass DJ, Sanes JR, Proszynski TJ. Α-Dystrobrevin-1 recruits Grb2 and α-catulin to organize neurotransmitter receptors at the neuromuscular junction. J Cell Sci. 2016;129(5):898-911. PMCID:PMC4813319  PMID:26769899 
16. Szafranski P, Dharmadhikari AV, Wambach JA, Towe CT, White FV, Grady RM, Eghtesady P, Cole FS, Deutsch G, Sen P, Stankiewicz P. Two deletions overlapping a distant FOXF1 enhancer unravel the role of lncRNA LINC01081 in etiology of alveolar capillary dysplasia with misalignment of pulmonary veins. Am J Med Genet A. 2014. doi:10.1002/ajmg.a.36606  PMID:24842713 
17. Hoganson DM, Gazit AZ, Boston US, Sweet SC, Grady RM, Huddleston CB, Eghtesady P. Paracorporeal lung assist devices as a bridge to recovery or lung transplantation in neonates and young children. J Thorac Cardiovasc Surg. 2014;147(1):420-6. doi:10.1016/j.jtcvs.2013.08.078  PMID:24199759 
18. Euteneuer J, Carvalho CM, Kulkarni S, Vineyard M, Grady RM, Lupski JR, Shinawi M. Molecular and phenotypic characterization of atypical Williams-Beuren syndrome. Clin Genet. 2013. doi:10.1111/cge.12305  PMID:24246242 
19. Hoganson DM, Gazit AZ, Sweet SC, Grady RM, Huddleston CB, Eghtesady P. Neonatal paracorporeal lung assist device for respiratory failure. Ann Thorac Surg. 2013;95(2):692-4. doi:10.1016/j.athoracsur.2012.05.128  PMID:23336880 
20. McDonnell CJ, White KS, Grady RM. Noncardiac chest pain in children and adolescents: a biopsychosocial conceptualization. Child Psychiatry Hum Dev. 2012;43(1):1-26. doi:10.1007/s10578-011-0240-7  PMID:21701910 
21. Goldstein BS, Sweet SC, Mao J, Huddleston CB, Grady RM. Lung transplantation in children with idiopathic pulmonary arterial hypertension: an 18-year experience. J Heart Lung Transplant. 2011;30(10):1148-52. doi:10.1016/j.healun.2011.04.009  PMID:21620736 
22. Gazit AZ, Sweet SC, Grady RM, Huddleston CB. First experience with a paracorporeal artificial lung in a small child with pulmonary hypertension. J Thorac Cardiovasc Surg. 2011;141(6):e48-50. doi:10.1016/j.jtcvs.2011.02.005  PMID:21420104 
23. Grady RM, Gandhi S, Sweet SC, Mao J, Huddleston CB. Dismal lung transplant outcomes in children with tetralogy of Fallot with pulmonary atresia compared to Eisenmenger syndrome or pulmonary vein stenosis. J Heart Lung Transplant. 2009;28(11):1221-5. doi:10.1016/j.healun.2009.07.010  PMID:19783168 
24. Gandhi SK, Grady RM, Huddleston CB, Balzer DT, Canter CE. Beyond Berlin: heart transplantation in the "untransplantable". J Thorac Cardiovasc Surg. 2008;136(2):529-31. doi:10.1016/j.jtcvs.2008.01.032  PMID:18692672 
25. Grady RM, Wozniak DF, Ohlemiller KK, Sanes JR. Cerebellar synaptic defects and abnormal motor behavior in mice lacking alpha- and beta-dystrobrevin. J Neurosci. 2006;26(11):2841-51. doi:10.1523/JNEUROSCI.4823-05.2006  PMID:16540561 
26. Grady RM, Starr DA, Ackerman GL, Sanes JR, Han M. Syne proteins anchor muscle nuclei at the neuromuscular junction. Proc Natl Acad Sci U S A. 2005;102(12):4359-64. doi:10.1073/pnas.0500711102  PMCID:PMC555524  PMID:15749817 
27. Grady RM, Akaaboune M, Cohen AL, Maimone MM, Lichtman JW, Sanes JR. Tyrosine-phosphorylated and nonphosphorylated isoforms of alpha-dystrobrevin: roles in skeletal muscle and its neuromuscular and myotendinous junctions. J Cell Biol. 2003;160(5):741-52. doi:10.1083/jcb.200209045  PMCID:PMC2173352  PMID:12604589 
28. Akaaboune M, Grady RM, Turney S, Sanes JR, Lichtman JW. Neurotransmitter receptor dynamics studied in vivo by reversible photo-unbinding of fluorescent ligands. Neuron. 2002;34(6):865-76. PMID:12086635 
29. Lévi S, Grady RM, Henry MD, Campbell KP, Sanes JR, Craig AM. Dystroglycan is selectively associated with inhibitory GABAergic synapses but is dispensable for their differentiation. J Neurosci. 2002;22(11):4274-85. doi:20026440  PMID:12040032 
30. Knuesel I, Riban V, Zuellig RA, Schaub MC, Grady RM, Sanes JR, Fritschy JM. Increased vulnerability to kainate-induced seizures in utrophin-knockout mice. Eur J Neurosci. 2002;15(9):1474-84. PMID:12028357 
31. Apel ED, Lewis RM, Grady RM, Sanes JR. Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction. J Biol Chem. 2000;275(41):31986-95. doi:10.1074/jbc.M004775200  PMID:10878022 
32. Grady RM, Zhou H, Cunningham JM, Henry MD, Campbell KP, Sanes JR. Maturation and maintenance of the neuromuscular synapse: genetic evidence for roles of the dystrophin--glycoprotein complex. Neuron. 2000;25(2):279-93. PMID:10719885 
33. Grady RM, Grange RW, Lau KS, Maimone MM, Nichol MC, Stull JT, Sanes JR. Role for alpha-dystrobrevin in the pathogenesis of dystrophin-dependent muscular dystrophies. Nat Cell Biol. 1999;1(4):215-20. doi:10.1038/12034  PMID:10559919 
34. Crosbie RH, Lebakken CS, Holt KH, Venzke DP, Straub V, Lee JC, Grady RM, Chamberlain JS, Sanes JR, Campbell KP. Membrane targeting and stabilization of sarcospan is mediated by the sarcoglycan subcomplex. J Cell Biol. 1999;145(1):153-65. PMCID:PMC2148225  PMID:10189375 
35. Sanes JR, Apel ED, Gautam M, Glass D, Grady RM, Martin PT, Nichol MC, Yancopoulos GD. Agrin receptors at the skeletal neuromuscular junction Ann N Y Acad Sci. 1998;841:1-13. PMID:9668217 
36. Sanes JR, Apel ED, Burgess RW, Emerson RB, Feng G, Gautam M, Glass D, Grady RM, Krejci E, Lichtman JW, Lu JT, Massoulié J, Miner JH, Moscoso LM, Nguyen Q, Nichol M, Noakes PG, Patton BL, Son YJ, Yancopoulos GD, Zhou H. Development of the neuromuscular junction: genetic analysis in mice. J Physiol Paris. 1998;92(3-4):167-72. PMID:9789802 
37. Peters MF, Sadoulet-Puccio HM, Grady RM, Kramarcy NR, Kunkel LM, Sanes JR, Sealock R, Froehner. Differential membrane localization and intermolecular associations of alpha-dystrobrevin isoforms in skeletal muscle Journal of Cell Biology. 1998;142:1269-1278. 
38. Grady RM, Teng H, Nichol MC, Cunningham JC, Wilkinson RS, Sanes JR. Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophy. Cell. 1997;90(4):729-38. PMID:9288752 
39. Grady RM, Merlie JP, Sanes JR. Subtle neuromuscular defects in utrophin-deficient mice. J Cell Biol. 1997;136(4):871-82. PMCID:PMC2132496  PMID:9049252 
40. Grady RM, Eisenberg PR, Bridges ND. Rational approach to use of heparin during cardiac catheterization in children. J Am Coll Cardiol. 1995;25(3):725-9. doi:10.1016/0735-1097(94)00438-V  PMID:7860920 
41. Grady RM, Sharkey AM, Bridges ND. Transcatheter coil embolisation of a pulmonary arteriovenous malformation in a neonate. Br Heart J. 1994;71(4):370-1. PMCID:PMC483690  PMID:8198890