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Gary A. Silverman, M.D., Ph.D.
gsilverman@wustl.edu
The Harriet B. Spoehrer Professor and Chairman, Department of Pediatrics
Executive Director, Children's Discovery Institute, Washington University School of Medicine/St. Louis Children's Hospital
Professor, Cell Biology & Physiology
Professor, Genetics
Researcher, Developmental Biology
Newborn Medicine
phone: (314) 454-6148
Education
BA,
Washington and Jefferson College
,
1978
PhD,
University of Chicago
,
1982
MD,
University of Chicago, Pritzer School of Medicine
,
1984
Training
Internship, The Children’s Hospital
,
1984
-
1985
Junior Assistant Resident, The Children’s Hospital
,
1985
-
1986
Senior Assistant Resident, The Children’s Hospital
,
1986
-
1987
Fellowship, St. Louis Children’s Hospital/Washington University School of Medicine
,
1987
-
1989
Postdoctoral Research Fellow, Washington University School of Medicine
,
1988
-
1991
Licensure and Board Certification
1985
National Board of Medical Examiners (Diplomate)
1987
-
1991
MO, Medical License
1988
American Board of Pediatrics, Pediatrics
1989
American Board of Pediatrics, Neonatal/Perinatal Medicine
1991
-
2004
MA, Medical License
1997
American Board of Pediatrics, Neonatal/Perinatal Medicine - recertification
2004
American Board of Pediatrics, Neonatal/Perinatal Medicine - recertification
2004
-
2016
PA, Medical License
2013
American Board of Pediatrics, Neonatal/Perinatal Medicine - recertification
2016
-
Pres
MO, Medical License
2020
American Board of Pediatrics, Neonatal/Perinatal Medicine - recertification #208826
Honors and Awards
Phi Sigma, Biology Honorary Society
,
1976
Phi Beta Kappa, Washington and Jefferson College
,
1978
Solon E. Summerfield Scholarship, Phi Kappa Psi Fraternity
,
1978
Birch Scholarship Award, Washington and Jefferson College
,
1978
National Science Foundation, Student Originated Studies Program
,
1978
National Research Service Award: Medical Scientist Training Program University of Chicago
,
1978
The Medical Alumni Prize, University of Chicago
,
1982
Individual National Research Service Award, NICHHD
,
1988
Leukemia Society Special Fellowship
,
1991
FIRST Award, National Institute of Child Health and Human Development
,
1991
Lucille P. Markey Trust Child Health Fellowship
,
1992
William Randolph Hearst Award
,
1992
March of Dimes Birth Defects Foundation Award
,
1993
Elsa U. Pardee Foundation Award
,
1994
Biology Smokeless Tobacco Research Council Award
,
1994
The Stewart Trust of Washington D.C., Alexander and Margaret Stewart Trust Grant, in Support of Promising Ideas in Basic and Applied Cancer
,
2001
Inaugural Class Hartwell Individual Biomedical Research Award
,
2006
Top Doctors, Pittsburgh Magazine
,
2009
Twenty-Five Club Endowed Professorship, University of Pittsburgh School of Medicine
,
2009
- 2016
Top Doctors, Pittsburgh Magazine
,
2010
Cellome Award, Thermo Scientific
,
2011
America’s Top Doctors, Castle Connolly
,
2011
Top Doctors, Pittsburgh Magazine
,
2011
Distinguished Service Award, Washington & Jefferson College
,
2011
America’s Top Doctors, Castle Connolly
,
2012
2014 AAP CME/CPD Award (Continuing Medical Education /Continuing Professional Development)
,
2014
Top Doctors, Pittsburgh Magazine
,
2015
2015 Marshall W. Webster Physician Leadership Program, University of Pittsburgh School of Medicine
,
2015
2015 Scholars Day Award, University of Pittsburgh School of Medicine
,
2015
The Harriet B. Spoehrer Professorship of Pediatrics, Washington University School of Medicine
,
2016
America’s Top Doctors, Castle Connolly
,
2016
America’s Top Doctors, Castle Connolly
,
2017
Fellow, American Association for the Advancement of Science
,
2018
WUSM Chapter of Alpha Omega Alpha (AOA) Honor Medical Society
,
2018
Recent Publications
view all (120)
Publication Co-Authors
Dustin Baldridge
Marco Sardiello
Cliff J. Luke, Ph.D.
David A. Rudnick, M.D., Ph.D.
Jennifer A Wambach, M.D.
Anthony W. Orvedahl, M.D., Ph.D.
Stephen C. Pak, Ph.D.
David Perlmutter, M.D.
Tunda Hidvegi, Ph.D.
Francis Sessions Cole, III, M.D.
Rudnick DA, Huang J, Hidvegi T, Chu AS, Hale P, Munanairi A, Dietzen DJ, Cliften PF, Tycksen E, Lutkewitte AJ, Finck BN, Pak SC, Silverman GA, Perlmutter DH.
Regulation of PGC1α downstream of the insulin signaling pathway plays a role in the hepatic proteotoxicity of mutant α1-antitrypsin deficiency variant Z.
Gastroenterology
.
2022.
PMID:
35301011
Luke CJ, Markovina S, Good M, Wight IE, Thomas BJ, Linneman JM, Lanik WE, Koroleva O, Coffman MR, Miedel MT, Gong Q, Andress A, Campos Guerrero M, Wang S, Chen L, Beatty WL, Hausmann KN, White FV, Fitzpatrick JAJ, Orvedahl A, Pak SC, Silverman GA.
Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins.
Commun Biol
.
2022;5
(1):
47.
PMID:
35022507
Wang S, Luke CJ, Pak SC, Shi V, Chen L, Moore J, Andress AP, Jayachandran K, Zhang J, Huang Y, Platik M, Apicelli AA, Schwarz JK, Grigsby PW, Silverman GA, Markovina S.
SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation.
Commun Biol
.
2022;5
(1):
46.
PMID:
35022555
Boulin T, Itani O, El Mouridi S, Leclercq-Blondel A, Gendrel M, Macnamara E, Soldatos A, Murphy JL, Gorman MP, Lindsey A, Shimada S, Turner D, Silverman GA, Baldridge D, Undiagnosed Diseases Network., Malicdan MC, Schedl T, Pak SC.
Functional analysis of a de novo variant in the neurodevelopment and generalized epilepsy disease gene NBEA.
Mol Genet Metab
.
2021;134
(1-2):
195-202.
PMID:
34412939
Hu JY, Yang P, Wegner DJ, Heins HB, Luke CJ, Li F, White FV, Silverman GA, Sessions Cole F, Wambach JA.
Functional characterization of four ATP-binding cassette transporter A3 gene (ABCA3) variants.
Hum Mutat
.
2020;41
(7):
1298-1307.
PMCID:
PMC7292786
PMID:
32196812
Shi Q, Pei F, Silverman GA, Pak SC, Perlmutter DH, Liu B, Bahar I.
Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis.
Int J Mol Sci
.
2020;21
(8).
PMCID:
PMC7215584
PMID:
32325894
Orvedahl A, McAllaster MR, Sansone A, Dunlap BF, Desai C, Wang YT, Balce DR, Luke CJ, Lee S, Orchard RC, Artyomov MN, Handley SA, Doench JG, Silverman GA, Virgin HW.
Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock.
Proc Natl Acad Sci U S A
.
2019;116
(33):
16497-16506.
PMCID:
PMC6697821
PMID:
31346084
Thomas BJ, Wight IE, Chou WYY, Moreno M, Dawson Z, Homayouni A, Huang H, Kim H, Jia H, Buland JR, Wambach JA, Cole FS, Pak SC, Silverman GA, Luke CJ.
CemOrange2 fusions facilitate multifluorophore subcellular imaging in C. elegans.
PLoS One
.
2019;14
(3):
e0214257.
PMCID:
PMC6435234
PMID:
30913273
Wang Y, Cobanoglu MC, Li J, Hidvegi T, Hale P, Ewing M, Chu AS, Gong Z, Muzumdar R, Pak SC, Silverman GA, Bahar I, Perlmutter DH.
An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z.
PLoS One
.
2019;14
(1):
e0209748.
PMCID:
PMC6343872
PMID:
30673724
Markovina S, Wang S, Henke LE, Luke CJ, Pak SC, DeWees T, Pfeifer JD, Schwarz JK, Liu W, Chen S, Mutch D, Wang X, Powell MA, Siegel BA, Dehdashti F, Silverman GA, Grigsby PW.
Serum squamous cell carcinoma antigen as an early indicator of response during therapy of cervical cancer.
Br J Cancer
.
2018;118
(1):
72-78.
PMCID:
PMC5765231
PMID:
29112685
Liu B, Oltvai ZN, Bayır H, Silverman GA, Pak SC, Perlmutter DH, Bahar I.
Quantitative assessment of cell fate decision between autophagy and apoptosis.
Sci Rep
.
2017;7
(1):
17605.
PMCID:
PMC5730598
PMID:
29242632
Shi S, Luke CJ, Miedel MT, Silverman GA, Kleyman TR.
Activation of the Caenorhabditis elegans Degenerin Channel by Shear Stress Requires the MEC-10 Subunit.
J Biol Chem
.
2016;291
(27):
14012-22.
PMCID:
PMC4933161
PMID:
27189943
O'Reilly LP, Knoerdel RR, Silverman GA, Pak SC.
High-Throughput, Liquid-Based Genome-Wide RNAi Screening in C. elegans.
Methods Mol Biol
.
2016;1470:151-62.
PMID:
27581291
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC Jr, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR Jr, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, Ciarcia R, Ciechomska IA, Ciriolo MR, Cirone M, Claerhout S, Clague MJ, Clària J, Clarke PG, Clarke R, Clementi E, Cleyrat C, Cnop M, Coccia EM, Cocco T, Codogno P, Coers J, Cohen EE, Colecchia D, Coletto L, Coll NS, Colucci-Guyon E, Comincini S, Condello M, Cook KL, Coombs GH, Cooper CD, Cooper JM, Coppens I, Corasaniti MT, Corazzari M, Corbalan R, Corcelle-Termeau E, Cordero MD, Corral-Ramos C, Corti O, Cossarizza A, Costelli P, Costes S, Cotman SL, Coto-Montes A, Cottet S, Couve E, Covey LR, Cowart LA, Cox JS, Coxon FP, Coyne CB, Cragg MS, Craven RJ, Crepaldi T, Crespo JL, Criollo A, Crippa V, Cruz MT, Cuervo AM, Cuezva JM, Cui T, Cutillas PR, Czaja MJ, Czyzyk-Krzeska MF, Dagda RK, Dahmen U, Dai C, Dai W, Dai Y, Dalby KN, Dalla Valle L, Dalmasso G, D'Amelio M, Damme M, Darfeuille-Michaud A, Dargemont C, Darley-Usmar VM, Dasarathy S, Dasgupta B, Dash S, Dass CR, Davey HM, Davids LM, Dávila D, Davis RJ, Dawson TM, Dawson VL, Daza P, de Belleroche J, de Figueiredo P, de Figueiredo RC, de la Fuente J, De Martino L, De Matteis A, De Meyer GR, De Milito A, De Santi M, de Souza W, De Tata V, De Zio D, Debnath J, Dechant R, Decuypere JP, Deegan S, Dehay B, Del Bello B, Del Re DP, Delage-Mourroux R, Delbridge LM, Deldicque L, Delorme-Axford E, Deng Y, Dengjel J, Denizot M, Dent P, Der CJ, Deretic V, Derrien B, Deutsch E, Devarenne TP, Devenish RJ, Di Bartolomeo S, Di Daniele N, Di Domenico F, Di Nardo A, Di Paola S, Di Pietro A, Di Renzo L, DiAntonio A, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dickey CA, Dickson RC, Diederich M, Digard P, Dikic I, Dinesh-Kumar SP, Ding C, Ding WX, Ding Z, Dini L, Distler JH, Diwan A, Djavaheri-Mergny M, Dmytruk K, Dobson RC, Doetsch V, Dokladny K, Dokudovskaya S, Donadelli M, Dong XC, Dong X, Dong Z, Donohue TM Jr, Doran KS, D'Orazi G, Dorn GW 2nd, Dosenko V, Dridi S, Drucker L, Du J, Du LL, Du L, du Toit A, Dua P, Duan L, Duann P, Dubey VK, Duchen MR, Duchosal MA, Duez H, Dugail I, Dumit VI, Duncan MC, Dunlop EA, Dunn WA Jr, Dupont N, Dupuis L, Durán RV, Durcan TM, Duvezin-Caubet S, Duvvuri U, Eapen V, Ebrahimi-Fakhari D, Echard A, Eckhart L, Edelstein CL, Edinger AL, Eichinger L, Eisenberg T, Eisenberg-Lerner A, Eissa NT, El-Deiry WS, El-Khoury V, Elazar Z, Eldar-Finkelman H, Elliott CJ, Emanuele E, Emmenegger U, Engedal N, Engelbrecht AM, Engelender S, Enserink JM, Erdmann R, Erenpreisa J, Eri R, Eriksen JL, Erman A, Escalante R, Eskelinen EL, Espert L, Esteban-Martínez L, Evans TJ, Fabri M, Fabrias G, Fabrizi C, Facchiano A, Færgeman NJ, Faggioni A, Fairlie WD, Fan C, Fan D, Fan J, Fang S, Fanto M, Fanzani A, Farkas T, Faure M, Favier FB, Fearnhead H, Federici M, Fei E, Felizardo TC, Feng H, Feng Y, Feng Y, Ferguson TA, Fernández ÁF, Fernandez-Barrena MG, Fernandez-Checa JC, Fernández-López A, Fernandez-Zapico ME, Feron O, Ferraro E, Ferreira-Halder CV, Fesus L, Feuer R, Fiesel FC, Filippi-Chiela EC, Filomeni G, Fimia GM, Fingert JH, Finkbeiner S, Finkel T, Fiorito F, Fisher PB, Flajolet M, Flamigni F, Florey O, Florio S, Floto RA, Folini M, Follo C, Fon EA, Fornai F, Fortunato F, Fraldi A, Franco R, Francois A, François A, Frankel LB, Fraser ID, Frey N, Freyssenet DG, Frezza C, Friedman SL, Frigo DE, Fu D, Fuentes JM, Fueyo J, Fujitani Y, Fujiwara Y, Fujiya M, Fukuda M, Fulda S, Fusco C, Gabryel B, Gaestel M, Gailly P, Gajewska M, Galadari S, Galili G, Galindo I, Galindo MF, Galliciotti G, Galluzzi L, Galluzzi L, Galy V, Gammoh N, Gandy S, Ganesan AK, Ganesan S, Ganley IG, Gannagé M, Gao FB, Gao F, Gao JX, García Nannig L, García Véscovi E, Garcia-Macía M, Garcia-Ruiz C, Garg AD, Garg PK, Gargini R, Gassen NC, Gatica D, Gatti E, Gavard J, Gavathiotis E, Ge L, Ge P, Ge S, Gean PW, Gelmetti V, Genazzani AA, Geng J, Genschik P, Gerner L, Gestwicki JE, Gewirtz DA, Ghavami S, Ghigo E, Ghosh D, Giammarioli AM, Giampieri F, Giampietri C, Giatromanolaki A, Gibbings DJ, Gibellini L, Gibson SB, Ginet V, Giordano A, Giorgini F, Giovannetti E, Girardin SE, Gispert S, Giuliano S, Gladson CL, Glavic A, Gleave M, Godefroy N, Gogal RM Jr, Gokulan K, Goldman GH, Goletti D, Goligorsky MS, Gomes AV, Gomes LC, Gomez H, Gomez-Manzano C, Gómez-Sánchez R, Gonçalves DA, Goncu E, Gong Q, Gongora C, Gonzalez CB, Gonzalez-Alegre P, Gonzalez-Cabo P, González-Polo RA, Goping IS, Gorbea C, Gorbunov NV, Goring DR, Gorman AM, Gorski SM, Goruppi S, Goto-Yamada S, Gotor C, Gottlieb RA, Gozes I, Gozuacik D, Graba Y, Graef M, Granato GE, Grant GD, Grant S, Gravina GL, Green DR, Greenhough A, Greenwood MT, Grimaldi B, Gros F, Grose C, Groulx JF, Gruber F, Grumati P, Grune T, Guan JL, Guan KL, Guerra B, Guillen C, Gulshan K, Gunst J, Guo C, Guo L, Guo M, Guo W, Guo XG, Gust AA, Gustafsson ÅB, Gutierrez E, Gutierrez MG, Gwak HS, Haas A, Haber JE, Hadano S, Hagedorn M, Hahn DR, Halayko AJ, Hamacher-Brady A, Hamada K, Hamai A, Hamann A, Hamasaki M, Hamer I, Hamid Q, Hammond EM, Han F, Han W, Handa JT, Hanover JA, Hansen M, Harada M, Harhaji-Trajkovic L, Harper JW, Harrath AH, 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O'Reilly LP, Long OS, Cobanoglu MC, Benson JA, Luke CJ, Miedel MT, Hale P, Perlmutter DH, Bahar I, Silverman GA, Pak SC.
A genome-wide RNAi screen identifies potential drug targets in a C. elegans model of α1-antitrypsin deficiency.
Hum Mol Genet
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2014;23
(19):
5123-32.
PMCID:
PMC4159156
PMID:
24838285
Long OS, Benson JA, Kwak JH, Luke CJ, Gosai SJ, O'Reilly LP, Wang Y, Li J, Vetica AC, Miedel MT, Stolz DB, Watkins SC, Züchner S, Perlmutter DH, Silverman GA, Pak SC.
A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover.
Hum Mol Genet
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2014;23
(19):
5109-22.
PMCID:
PMC4159155
PMID:
24838286
O'Reilly LP, Benson JA, Cummings EE, Perlmutter DH, Silverman GA, Pak SC.
Worming our way to novel drug discovery with the Caenorhabditis elegans proteostasis network, stress response and insulin-signaling pathways.
Expert Opin Drug Discov
.
2014;9
(9):
1021-32.
PMID:
24998976
Ghazi A, Yanowitz J, Silverman GA.
Expanding the C. elegans toolbox into a toolshed.
Methods
.
2014;68
(3):
379-80.
PMCID:
PMC5408735
PMID:
25064639
Miedel MT, Zeng X, Yates NA, Silverman GA, Luke CJ.
Isolation of serpin-interacting proteins in C. elegans using protein affinity purification.
Methods
.
2014;68
(3):
536-41.
PMCID:
PMC4113314
PMID:
24798811
O'Reilly LP, Luke CJ, Perlmutter DH, Silverman GA, Pak SC.
C. elegans in high-throughput drug discovery.
Adv Drug Deliv Rev
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2014;69-70:247-53.
PMCID:
PMC4019719
PMID:
24333896
O'Reilly LP, Perlmutter DH, Silverman GA, Pak SC.
α1-antitrypsin deficiency and the hepatocytes - an elegans solution to drug discovery.
Int J Biochem Cell Biol
.
2014;47:109-12.
PMCID:
PMC3970812
PMID:
24355812
Li J, Pak SC, O'Reilly LP, Benson JA, Wang Y, Hidvegi T, Hale P, Dippold C, Ewing M, Silverman GA, Perlmutter DH.
Fluphenazine reduces proteotoxicity in C. elegans and mammalian models of alpha-1-antitrypsin deficiency.
PLoS One
.
2014;9
(1):
e87260.
PMCID:
PMC3909079
PMID:
24498058
Heit C, Jackson BC, McAndrews M, Wright MW, Thompson DC, Silverman GA, Nebert DW, Vasiliou V.
Update of the human and mouse SERPIN gene superfamily.
Hum Genomics
.
2013;7:22.
PMCID:
PMC3880077
PMID:
24172014
Chotoo CK, Silverman GA, Devor DC, Luke CJ.
A small conductance calcium-activated K+ channel in C. elegans, KCNL-2, plays a role in the regulation of the rate of egg-laying.
PLoS One
.
2013;8
(9):
e75869.
PMCID:
PMC3769271
PMID:
24040423
Silverman GA, Pak SC, Perlmutter DH.
Disorders of protein misfolding: alpha-1-antitrypsin deficiency as prototype.
J Pediatr
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2013;163
(2):
320-6.
PMCID:
PMC3725216
PMID:
23664631
Miedel MT, Graf NJ, Stephen KE, Long OS, Pak SC, Perlmutter DH, Silverman GA, Luke CJ.
A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans.
PLoS One
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2012;7
(7):
e40145.
PMCID:
PMC3388072
PMID:
22768338
Kantyka T, Plaza K, Koziel J, Florczyk D, Stennicke HR, Thogersen IB, Enghild JJ, Silverman GA, Pak SC, Potempa J.
Inhibition of Staphylococcus aureus cysteine proteases by human serpin potentially limits staphylococcal virulence.
Biol Chem
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2011;392
(5):
483-9.
PMCID:
PMC4372843
PMID:
21476872
Perlmutter DH, Silverman GA.
Hepatic fibrosis and carcinogenesis in α1-antitrypsin deficiency: a prototype for chronic tissue damage in gain-of-function disorders.
Cold Spring Harb Perspect Biol
.
2011;3
(3).
PMCID:
PMC3039936
PMID:
21421920
Luke CJ, Silverman GA.
Necrotic cell death: harnessing the Dark side of the Force in mammary gland involution.
Nat Cell Biol
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2011;13
(3):
197-9.
PMID:
21364568
Sivaprasad U, Askew DJ, Ericksen MB, Gibson AM, Stier MT, Brandt EB, Bass SA, Daines MO, Chakir J, Stringer KF, Wert SE, Whitsett JA, Le Cras TD, Wills-Karp M, Silverman GA, Khurana Hershey GK.
A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma.
J Allergy Clin Immunol
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2011;127
(1):
254-61, 261.e1-6.
PMCID:
PMC3058372
PMID:
21126757
Long OS, Gosai SJ, Kwak JH, King DE, Perlmutter DH, Silverman GA, Pak SC.
Using Caenorhabditis elegans to study serpinopathies.
Methods Enzymol
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2011;499:259-81.
PMCID:
PMC4374434
PMID:
21683258
Bhatia SR, Miedel MT, Chotoo CK, Graf NJ, Hood BL, Conrads TP, Silverman GA, Luke CJ.
Using C. elegans to identify the protease targets of serpins in vivo.
Methods Enzymol
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2011;499:283-99.
PMCID:
PMC4374438
PMID:
21683259
Gosai SJ, Kwak JH, Luke CJ, Long OS, King DE, Kovatch KJ, Johnston PA, Shun TY, Lazo JS, Perlmutter DH, Silverman GA, Pak SC.
Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z.
PLoS One
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2010;5
(11):
e15460.
PMCID:
PMC2980495
PMID:
21103396
Reece ST, Loddenkemper C, Askew DJ, Zedler U, Schommer-Leitner S, Stein M, Mir FA, Dorhoi A, Mollenkopf HJ, Silverman GA, Kaufmann SH.
Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice.
J Clin Invest
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2010;120
(9):
3365-76.
PMCID:
PMC2929725
PMID:
20679732
Whisstock JC, Silverman GA, Bird PI, Bottomley SP, Kaiserman D, Luke CJ, Pak SC, Reichhart JM, Huntington JA.
Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions.
J Biol Chem
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2010;285
(32):
24307-12.
PMCID:
PMC2915666
PMID:
20498368
Silverman GA, Whisstock JC, Bottomley SP, Huntington JA, Kaiserman D, Luke CJ, Pak SC, Reichhart JM, Bird PI.
Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems.
J Biol Chem
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2010;285
(32):
24299-305.
PMCID:
PMC2915665
PMID:
20498369
Yin L, Swanson B, An J, Hacker BM, Silverman GA, Dale BA, Chung WO.
Differential effects of periopathogens on host protease inhibitors SLPI, elafin, SCCA1, and SCCA2.
J Oral Microbiol
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2010;2.
PMCID:
PMC3084571
PMID:
21523231
Silverman GA, Luke CJ, Bhatia SR, Long OS, Vetica AC, Perlmutter DH, Pak SC.
Modeling molecular and cellular aspects of human disease using the nematode Caenorhabditis elegans.
Pediatr Res
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2009;65
(1):
10-8.
PMCID:
PMC2731241
PMID:
18852689
Askew DJ, Silverman GA.
Intracellular and extracellular serpins modulate lung disease.
J Perinatol
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2008;28 Suppl 3:S127-35.
PMID:
19057604
Ong PC, McGowan S, Pearce MC, Irving JA, Kan WT, Grigoryev SA, Turk B, Silverman GA, Brix K, Bottomley SP, Whisstock JC, Pike RN.
DNA accelerates the inhibition of human cathepsin V by serpins.
J Biol Chem
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2007;282
(51):
36980-6.
PMID:
17923478
Luke CJ, Pak SC, Askew YS, Naviglia TL, Askew DJ, Nobar SM, Vetica AC, Long OS, Watkins SC, Stolz DB, Barstead RJ, Moulder GL, Brömme D, Silverman GA.
An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury.
Cell
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2007;130
(6):
1108-19.
PMCID:
PMC2128786
PMID:
17889653
Askew DJ, Cataltepe S, Kumar V, Edwards C, Pace SM, Howarth RN, Pak SC, Askew YS, Brömme D, Luke CJ, Whisstock JC, Silverman GA.
SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change.
J Biol Chem
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2007;282
(34):
24948-60.
PMID:
17562709
Badola S, Spurling H, Robison K, Fedyk ER, Silverman GA, Strayle J, Kapeller R, Tsu CA.
Correlation of serpin-protease expression by comparative analysis of real-time PCR profiling data.
Genomics
.
2006;88
(2):
173-84.
PMID:
16713170
Pak SC, Tsu C, Luke CJ, Askew YS, Silverman GA.
The Caenorhabditis elegans muscle specific serpin, SRP-3, neutralizes chymotrypsin-like serine peptidases.
Biochemistry
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2006;45
(14):
4474-80.
PMCID:
PMC2654365
PMID:
16584183
Nakashima T, Yasumatsu R, Kuratomi Y, Masuda M, Kuwano T, Toh S, Umezaki T, Cataltepe S, Silverman GA, Komune S.
Role of squamous cell carcinoma antigen 1 expression in the invasive potential of head and neck squamous cell carcinoma.
Head Neck
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2006;28
(1):
24-30.
PMID:
16155915
Law RH, Zhang Q, McGowan S, Buckle AM, Silverman GA, Wong W, Rosado CJ, Langendorf CG, Pike RN, Bird PI, Whisstock JC.
An overview of the serpin superfamily.
Genome Biol
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2006;7
(5):
216.
PMCID:
PMC1779521
PMID:
16737556
Luke CJ, Pak SC, Askew DJ, Askew YS, Smith JE, Silverman GA.
Selective conservation of the RSL-encoding, proteinase inhibitory-type, clade L serpins in Caenorhabditis species.
Front Biosci
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2006;11:581-94.
PMID:
16146754
Yasuda S, Morokawa N, Wong GW, Rossi A, Madhusudhan MS, Sali A, Askew YS, Adachi R, Silverman GA, Krilis SA, Stevens RL.
Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22.
Blood
.
2005;105
(10):
3893-901.
PMCID:
PMC1895090
PMID:
15701722
Ray R, Choi M, Zhang Z, Silverman GA, Askew D, Mukherjee AB.
Uteroglobin suppresses SCCA gene expression associated with allergic asthma.
J Biol Chem
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2005;280
(11):
9761-4.
PMID:
15677460
Cole EB, Miller D, Rometo D, Greenberg RM, Brömme D, Cataltepe S, Pak SC, Mills DR, Silverman GA, Luke CJ.
Identification and activity of a lower eukaryotic serine proteinase inhibitor (serpin) from Cyanea capillata: analysis of a jellyfish serpin, jellypin.
Biochemistry
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2004;43
(37):
11750-9.
PMID:
15362859
Askew DJ, Askew YS, Kato Y, Luke CJ, Pak SC, Brömme D, Silverman GA.
The amplified mouse squamous cell carcinoma antigen gene locus contains a serpin (Serpinb3b) that inhibits both papain-like cysteine and trypsin-like serine proteinases.
Genomics
.
2004;84
(1):
166-75.
PMID:
15203214
Askew DJ, Askew YS, Kato Y, Turner RF, Dewar K, Lehoczky J, Silverman GA.
Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus.
Genomics
.
2004;84
(1):
176-84.
PMID:
15203215
Pak SC, Kumar V, Tsu C, Luke CJ, Askew YS, Askew DJ, Mills DR, Brömme D, Silverman GA.
SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins.
J Biol Chem
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2004;279
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15448-59.
PMID:
14739286
Silverman GA, Lomas DA.
Serpin identification, production, and characterization.
Methods
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2004;32
(2):
71-2.
PMID:
14698620
Jayakumar A, Cataltepe S, Kang Y, Frederick MJ, Mitsudo K, Henderson Y, Crawford SE, Silverman GA, Clayman GL.
Production of serpins using baculovirus expression systems.
Methods
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2004;32
(2):
177-84.
PMID:
14698630
Silverman GA, Whisstock JC, Askew DJ, Pak SC, Luke CJ, Cataltepe S, Irving JA, Bird PI.
Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis.
Cell Mol Life Sci
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2004;61
(3):
301-25.
PMID:
14770295
Nustad K, Dowell BL, Davis GJ, Stewart K, Nilsson O, Röijer E, Suminami Y, Nawata S, Cataltepe S, Silverman GA, Kato H, de Bruijn HW.
Characterization of monoclonal antibodies directed against squamous cell carcinoma antigens: report of the TD-10 Workshop.
Tumour Biol
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2004;25
(1-2):
69-90.
PMID:
15192315
Gariboldi M, Peissel B, Fabbri A, Saran A, Zaffaroni D, Falvella FS, Spinola M, Tanuma J, Pazzaglia S, Mancuso MT, Maurichi A, Bartoli C, Cataltepe S, Silverman GA, Pilotti S, Hayashizaki Y, Okazaki Y, Dragani TA.
SCCA2-like serpins mediate genetic predisposition to skin tumors.
Cancer Res
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2003;63
(8):
1871-5.
PMID:
12702576
Jayakumar A, Kang Y, Frederick MJ, Pak SC, Henderson Y, Holton PR, Mitsudo K, Silverman GA, EL-Naggar AK, Brömme D, Clayman GL.
Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin (SERPINB13): a kinetic analysis.
Arch Biochem Biophys
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2003;409
(2):
367-74.
PMID:
12504904
Irving JA, Pike RN, Dai W, Brömme D, Worrall DM, Silverman GA, Coetzer TH, Dennison C, Bottomley SP, Whisstock JC.
Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases.
Biochemistry
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2002;41
(15):
4998-5004.
PMID:
11939796
Al-Khunaizi M, Luke CJ, Askew YS, Pak SC, Askew DJ, Cataltepe S, Miller D, Mills DR, Tsu C, Brömme D, Irving JA, Whisstock JC, Silverman GA.
The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases.
Biochemistry
.
2002;41
(9):
3189-99.
PMID:
11863458
Yasumatsu R, Nakashima T, Kuratomi Y, Hirakawa N, Azuma K, Tomita K, Cataltepe S, Silverman GA, Clayman GL, Komiyama S.
Serum squamous cell carcinoma antigen is a useful biologic marker in patients with inverted papillomas of the sinonasal tract.
Cancer
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2002;94
(1):
152-8.
PMID:
11815971
Askew YS, Pak SC, Luke CJ, Askew DJ, Cataltepe S, Mills DR, Kato H, Lehoczky J, Dewar K, Birren B, Silverman GA.
SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases.
J Biol Chem
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2001;276
(52):
49320-30.
PMID:
11604408
Silverman GA, Bird PI, Carrell RW, Church FC, Coughlin PB, Gettins PG, Irving JA, Lomas DA, Luke CJ, Moyer RW, Pemberton PA, Remold-O'Donnell E, Salvesen GS, Travis J, Whisstock JC.
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature.
J Biol Chem
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2001;276
(36):
33293-6.
PMID:
11435447
Yasumatsu R, Nakashima T, Azuma K, Hirakawa N, Kuratomi Y, Tomita K, Cataltepe S, Silverman GA, Clayman GL, Komiyama S.
SCCA1 expression in T-lymphocytes peripheral to cancer cells is associated with the elevation of serum SCC antigen in squamous cell carcinoma of the tongue.
Cancer Lett
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2001;167
(2):
205-13.
PMID:
11369142
Suminami Y, Nagashima S, Murakami A, Nawata S, Gondo T, Hirakawa H, Numa F, Silverman GA, Kato H.
Suppression of a squamous cell carcinoma (SCC)-related serpin, SCC antigen, inhibits tumor growth with increased intratumor infiltration of natural killer cells.
Cancer Res
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2001;61
(5):
1776-80.
PMID:
11280721
Nakashima T, Pak SC, Silverman GA, Spring PM, Frederick MJ, Clayman GL.
Genomic cloning, mapping, structure and promoter analysis of HEADPIN, a serpin which is down-regulated in head and neck cancer cells.
Biochim Biophys Acta
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2000;1492
(2-3):
441-6.
PMID:
11004515
Uemura Y, Pak SC, Luke C, Cataltepe S, Tsu C, Schick C, Kamachi Y, Pomeroy SL, Perlmutter DH, Silverman GA.
Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells.
Int J Cancer
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2000;89
(4):
368-77.
PMID:
10956412
Luke C, Schick C, Tsu C, Whisstock JC, Irving JA, Brömme D, Juliano L, Shi GP, Chapman HA, Silverman GA.
Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage.
Biochemistry
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2000;39
(24):
7081-91.
PMID:
10852705
Cataltepe S, Schick C, Luke CJ, Pak SC, Goldfarb D, Chen P, Tanasiyevic MJ, Posner MR, Silverman GA.
Development of specific monoclonal antibodies and a sensitive discriminatory immunoassay for the circulating tumor markers SCCA1 and SCCA2.
Clin Chim Acta
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2000;295
(1-2):
107-27.
PMID:
10767398
Ruzindana-Umunyana A, Sircar S, Schick C, Silverman GA, Weber JM.
Adenovirus endopeptidase hydrolyses human squamous cell carcinoma antigens in vitro but not ex vivo.
Virology
.
2000;268
(1):
141-6.
PMID:
10683336
Cataltepe S, Gornstein ER, Schick C, Kamachi Y, Chatson K, Fries J, Silverman GA, Upton MP.
Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas.
J Histochem Cytochem
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2000;48
(1):
113-22.
PMID:
10653592
Katz SG, Schneider SS, Bartuski A, Trask BJ, Massa H, Overhauser J, Lalande M, Lansdorp PM, Silverman GA.
An 18q- syndrome breakpoint resides between the duplicated serpins SCCA1 and SCCA2 and arises via a cryptic rearrangement with satellite III DNA.
Hum Mol Genet
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1999;8
(1):
87-92.
PMID:
9887335
Bartuski AJ, Kamachi Y, Schick C, Massa H, Trask BJ, Silverman GA.
A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases.
Genomics
.
1998;54
(2):
297-306.
PMID:
9828132
Schick C, Brömme D, Bartuski AJ, Uemura Y, Schechter NM, Silverman GA.
The reactive site loop of the serpin SCCA1 is essential for cysteine proteinase inhibition.
Proc Natl Acad Sci U S A
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1998;95
(23):
13465-70.
PMCID:
PMC24842
PMID:
9811823
Tamura A, Akagi T, Nakazawa N, Kashima K, Nakamura S, Karpas A, Silverman GA, Morishima Y, Taniwaki M, Seto M.
Delineation of the breakpoint at 18q21.1 in a cell line (Karpas1106) derived from mediastinal B-cell lymphoma by fluorescence in situ hybridization with multiple YAC clones.
Int J Cancer
.
1998;78
(1):
100-5.
PMID:
9724100
Zeng W, Silverman GA, Remold-O'Donnell E.
Structure and sequence of human M/NEI (monocyte/neutrophil elastase inhibitor), an Ov-serpin family gene.
Gene
.
1998;213
(1-2):
179-87.
PMID:
9630619
Thakker-Varia S, Elkabes S, Schick C, Silverman GA, Peng L, Sherwood AC, Black IB.
Gene expression in activated brain microglia: identification of a proteinase inhibitor that increases microglial cell number.
Brain Res Mol Brain Res
.
1998;56
(1-2):
99-107.
PMID:
9602079
Schick C, Pemberton PA, Shi GP, Kamachi Y, Cataltepe S, Bartuski AJ, Gornstein ER, Brömme D, Chapman HA, Silverman GA.
Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis.
Biochemistry
.
1998;37
(15):
5258-66.
PMID:
9548757
Bartuski AJ, Kamachi Y, Schick C, Overhauser J, Silverman GA.
Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3.
Genomics
.
1997;43
(3):
321-8.
PMID:
9268635
Taniwaki M, Ueda Y, Nishida K, Takashima T, Kashima K, Matsuda F, Silverman GA.
Rapid detection of lymphoma-specific translocations in interphase nuclei of non-Hodgkin's lymphoma by fluorescence in situ hybridization.
Leukemia
.
1997;11 Suppl 3:291-3.
PMID:
9209369
Schick C, Kamachi Y, Bartuski AJ, Cataltepe S, Schechter NM, Pemberton PA, Silverman GA.
Squamous cell carcinoma antigen 2 is a novel serpin that inhibits the chymotrypsin-like proteinases cathepsin G and mast cell chymase.
J Biol Chem
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1997;272
(3):
1849-55.
PMID:
8999871
Silverman GA, Overhauser J, Gerken S, Aburomia R, O'Connell P, Krauter KS, Detera-Wadleigh SD, Yoshikawa T, Collins AR, Geurts van Kessel A.
Report of the Fourth International Workshop on Human Chromosome 18 Mapping. Boston, Massachusetts, October 7-9, 1996.
Cytogenet Cell Genet
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1996;75
(2-3):
111-31.
PMID:
9040777
Taniwaki M, Sliverman GA, Nishida K, Horiike S, Misawa S, Shimazaki C, Miura I, Nagai M, Abe M, Fukuhara S.
Translocations and amplification of the BCL2 gene are detected in interphase nuclei of non-Hodgkin's lymphoma by in situ hybridization with yeast artificial chromosome clones.
Blood
.
1995;86
(4):
1481-6.
PMID:
7632955
Belaaouaj A, Shipley JM, Kobayashi DK, Zimonjic DB, Popescu N, Silverman GA, Shapiro SD.
Human macrophage metalloelastase. Genomic organization, chromosomal location, gene linkage, and tissue-specific expression.
J Biol Chem
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1995;270
(24):
14568-75.
PMID:
7782320
Schneider SS, Schick C, Fish KE, Miller E, Pena JC, Treter SD, Hui SM, Silverman GA.
A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene.
Proc Natl Acad Sci U S A
.
1995;92
(8):
3147-51.
PMCID:
PMC42122
PMID:
7724531
Silverman GA, Schneider SS, Massa HF, Flint A, Lalande M, Leonard JC, Overhauser J, van den Engh G, Trask BJ.
The 18q- syndrome: analysis of chromosomes by bivariate flow karyotyping and the PCR reveals a successive set of deletion breakpoints within 18q21.2-q22.2.
Am J Hum Genet
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1995;56
(4):
926-37.
PMCID:
PMC1801205
PMID:
7717403
Hui SM, Trask B, van den Engh G, Bartuski AJ, Smith A, Flint A, Lalande M, Silverman GA.
Analysis of randomly amplified flow-sorted chromosomes using the polymerase chain reaction.
Genomics
.
1995;26
(2):
364-71.
PMID:
7601463
Overhauser J, Silverman GA, Gerken S, Geurts van Kessel A.
Report of the Third International Workshop on human chromosome 18 mapping 1995.
Cytogenet Cell Genet
.
1995;71
(2):
106-17.
PMID:
7656577
Rojas K, Silverman GA, Hudson JR Jr, Overhauser J.
Integration of the 1993-94 Généthon genetic linkage map for chromosome 18 with the physical map using a somatic cell hybrid mapping panel.
Genomics
.
1995;25
(1):
329-30.
PMID:
7774947
Gerken S, Fish K, Uyar D, Polymeropoulos MH, Bradley P, White R, Overhauser J, Silverman GA.
Integration of 28 STSs into the physical map of human chromosome 18.
Genomics
.
1994;24
(3):
612-3.
PMID:
7713522
Khurana TS, Engle EC, Bennett RR, Silverman GA, Selig S, Bruns GA, Kunkel LM.
(CA) repeat polymorphism in the chromosome 18 encoded dystrophin-like protein.
Hum Mol Genet
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1994;3
(5):
841.
PMID:
8081380
Cho KR, Oliner JD, Simons JW, Hedrick L, Fearon ER, Preisinger AC, Hedge P, Silverman GA, Vogelstein B.
The DCC gene: structural analysis and mutations in colorectal carcinomas.
Genomics
.
1994;19
(3):
525-31.
PMID:
8188295
van Kessel AG, Straub RE, Silverman GA, Gerken S, Overhauser J.
Report and abstracts of the second international workshop on human chromosome 18 mapping. Doorwerth, the Netherlands, July 19-20, 1993.
Cytogenet Cell Genet
.
1994;65
(3):
142-65.
PMID:
8222751
Chang E, Luna J, Giacalone J, Uyar D, Silverman GA, Francke U.
Regional localization of 56 new human chromosome 18-specific yeast artificial chromosomes.
Cytogenet Cell Genet
.
1994;65
(1-2):
136-9.
PMID:
8404067
Silverman GA.
Isolating vector-insert junctions from yeast artificial chromosomes.
PCR Methods Appl
.
1993;3
(3):
141-50.
PMID:
8118395
Silverman GA, Yang E, Proffitt JH, Zutter M, Korsmeyer SJ.
Genetic transfer and expression of reconstructed yeast artificial chromosomes containing normal and translocated BCL2 proto-oncogenes.
Mol Cell Biol
.
1993;13
(9):
5469-78.
PMCID:
PMC360259
PMID:
8355694
Domer PH, Fakharzadeh SS, Chen CS, Jockel J, Johansen L, Silverman GA, Kersey JH, Korsmeyer SJ.
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product.
Proc Natl Acad Sci U S A
.
1993;90
(16):
7884-8.
PMCID:
PMC47247
PMID:
7689231
Silverman GA, Jenkins R, Bruns GA, LeBeau MM.
Reassignment of pEFD70.3 (D18S23) to human chromosome band 21q22.2 (D21S412) by physical mapping.
Hum Mol Genet
.
1993;2
(3):
331.
PMID:
8499926
Lia KM, Bruns GA, LeBeau MM, Silverman GA.
pMCT108.2 is a chimaeric clone which physically maps to human chromosome bands 9q33 (D9S203) and 18q21.1 (D18S24).
Hum Mol Genet
.
1993;2
(3):
332.
PMID:
8499927
Caughey GH, Schaumberg TH, Zerweck EH, Butterfield JH, Hanson RD, Silverman GA, Ley TJ.
The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression.
Genomics
.
1993;15
(3):
614-20.
PMID:
8468056
Silverman GA, Kuo WL, Taillon-Miller P, Gray JW.
Chromosomal reassignment: YACs containing both YES1 and thymidylate synthase map to the short arm of chromosome 18.
Genomics
.
1993;15
(2):
442-5.
PMID:
8449516
Overhauser J, Mewar R, Rojas K, Lia K, Kline AD, Silverman GA.
STS map of genes and anonymous DNA fragments on human chromosome 18 using a panel of somatic cell hybrids.
Genomics
.
1993;15
(2):
387-91.
PMID:
8449504
Le Beau MM, Overhauser J, Straub RE, Silverman G, Gilliam TC, Ott J, O'Connell P, Francke U, Geurts van Kessel A.
Report of the first international workshop on human chromosome 18 mapping.
Cytogenet Cell Genet
.
1993;63
(2):
78-96.
PMID:
8096808
Zutter M, Hockenbery D, Silverman GA, Korsmeyer SJ.
Immunolocalization of the Bcl-2 protein within hematopoietic neoplasms.
Blood
.
1991;78
(4):
1062-8.
PMID:
1868240
Heusel JW, Hanson RD, Silverman GA, Ley TJ.
Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2.
J Biol Chem
.
1991;266
(10):
6152-8.
PMID:
2007574
Silverman GA, Jockel JI, Domer PH, Mohr RM, Taillon-Miller P, Korsmeyer SJ.
Yeast artificial chromosome cloning of a two-megabase-size contig within chromosomal band 18q21 establishes physical linkage between BCL2 and plasminogen activator inhibitor type-2.
Genomics
.
1991;9
(2):
219-28.
PMID:
2004771
Silverman GA, Green ED, Young RL, Jockel JI, Domer PH, Korsmeyer SJ.
Meiotic recombination between yeast artificial chromosomes yields a single clone containing the entire BCL2 protooncogene.
Proc Natl Acad Sci U S A
.
1990;87
(24):
9913-7.
PMCID:
PMC55284
PMID:
2263642
Silverman GA, Ye RD, Pollock KM, Sadler JE, Korsmeyer SJ.
Use of yeast artificial chromosome clones for mapping and walking within human chromosome segment 18q21.3.
Proc Natl Acad Sci U S A
.
1989;86
(19):
7485-9.
PMCID:
PMC298089
PMID:
2678105
Brownstein BH, Silverman GA, Little RD, Burke DT, Korsmeyer SJ, Schlessinger D, Olson MV.
Isolation of single-copy human genes from a library of yeast artificial chromosome clones.
Science
.
1989;244
(4910):
1348-51.
PMID:
2544027
Silverman GA, Peri BA, Fitch FW, Rothberg RM.
Enterically induced regulation of systemic immune responses. II. Suppression of proliferating T cells by an Lyt-1+, 2- T effector cell.
J Immunol
.
1983;131
(6):
2656-61.
PMID:
6196395
Silverman GA, Peri BA, Fitch FW, Rothberg RM.
Enterically induced regulation of systemic immune responses. I. Lymphoproliferative responses in mice suppressed by ingested antigen.
J Immunol
.
1983;131
(6):
2651-5.
PMID:
6196394
Silverman GA, Peri BA, Rothberg RM.
Specifically induced suppression of T cell and NK-like cytolytic activity by ingested soluble antigens.
Cell Immunol
.
1983;80
(1):
115-29.
PMID:
6603272
Silverman GA, Peri BA, Rothberg RM.
Systemic antibody responses of different species following ingestion of soluble protein antigens.
Dev Comp Immunol
.
1982;6
(4):
737-46.
PMID:
7160515
Check JH, Silverman GA, Dryden RL, Brady LW.
Inhibition of spontaneous AKR leukemia by multiple inoculations of Corynebacterium parvum.
Cancer
.
1979;44
(2):
488-91.
PMID:
476565
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