Daniel W. Coyne, Hem N. Singh, WIlliam T. Smith, Ana Carolina Giuseppi, Jamie N. Connarn, Matthew L. Sherman, Frank Dellanna, Hartmut H. Malluche, Keith A. Hruska. Sotatercept Safety and Effects on Hemoglobin, Bone, and Vascular Calcification ISN KI Reports. 2019;In press.
Wu J, Dong J, Verzola D, Hruska KA, Garibotto G, Hu Z, Mitch WE, Thomas SS . SIRPa Initiates Cachexia Through Muscle to Adipose Tissue Crosstalk JCSM. 2019.
Hruska KA, Mahjoub MR. New pathogenic insights inform therapeutic target development for renal osteodystrophy. Kidney Int. 2019;95(2):261-263. PMID:30665565 Olson PD, McLellan LK, Hreha TN, Liu A, Briden KE, Hruska KA, Hunstad DA. Androgen exposure potentiates formation of intratubular communities and renal abscesses by Escherichia coli. Kidney Int. 2018;94(3):502-513. PMCID:PMC6109434 PMID:30041870 Gravesen E, Lerche Mace M, Nordholm A, Hofman-Bang J, Hruska K, Haagen Nielsen C, Kjær A, Olgaard K, Lewin E. Exogenous BMP7 in aortae of rats with chronic uremia ameliorates expression of profibrotic genes, but does not reverse established vascular calcification. PLoS One. 2018;13(1):e0190820. PMCID:PMC5755916 PMID:29304096 Williams MJ, Sugatani T, Agapova OA, Fang Y, Gaut JP, Faugere MC, Malluche HH, Hruska KA. The activin receptor is stimulated in the skeleton, vasculature, heart, and kidney during chronic kidney disease. Kidney Int. 2018;93(1):147-158. PMID:28843411 Olson PD, McLellan LK, Liu A, Briden KE, Tiemann KM, Daugherty AL, Hruska KA, Hunstad DA. Renal scar formation and kidney function following antibiotic-treated murine pyelonephritis. Dis Model Mech. 2017;10(11):1371-1379. PMCID:PMC5719254 PMID:28882930 Hruska KA, Lanske B, Moe OW. Crosstalk between kidney and bone - Bench to bedside. Bone. 2017;100:1-3. PMID:28412470 Hruska KA, Sugatani T, Agapova O, Fang Y. The chronic kidney disease - Mineral bone disorder (CKD-MBD): Advances in pathophysiology. Bone. 2017;100:80-86. PMCID:PMC5502716 PMID:28119179 Sugatani T, Agapova OA, Fang Y, Berman AG, Wallace JM, Malluche HH, Faugere MC, Smith W, Sung V, Hruska KA. Ligand trap of the activin receptor type IIA inhibits osteoclast stimulation of bone remodeling in diabetic mice with chronic kidney disease. Kidney Int. 2017;91(1):86-95. PMCID:PMC5530394 PMID:27666759 Wagenknecht LE, Divers J, Register TC, Russell GB, Bowden DW, Xu J, Langefeld CD, Lenchik L, Hruska KA, Carr JJ, Freedman BI. Bone Mineral Density and Progression of Subclinical Atherosclerosis in African-Americans With Type 2 Diabetes. J Clin Endocrinol Metab. 2016;101(11):4135-4141. PMCID:PMC5095232 PMID:27552541 Agapova OA, Fang Y, Sugatani T, Seifert ME, Hruska KA. Ligand trap for the activin type IIA receptor protects against vascular disease and renal fibrosis in mice with chronic kidney disease. Kidney Int. 2016;89(6):1231-43. PMCID:PMC4868771 PMID:27165838 Olson PD, Hruska KA, Hunstad DA. Androgens Enhance Male Urinary Tract Infection Severity in a New Model. J Am Soc Nephrol. 2016;27(6):1625-34. PMCID:PMC4884108 PMID:26449605 Seifert ME, Ashoor IF, Chiang ML, Chishti AS, Dietzen DJ, Gipson DS, Janjua HS, Selewski DT, Hruska KA. Fibroblast growth factor-23 and chronic allograft injury in pediatric renal transplant recipients: a Midwest Pediatric Nephrology Consortium study. Pediatr Transplant. 2016;20(3):378-87. PMCID:PMC4818682 PMID:26880121 Seifert ME, Hruska KA. The Kidney-Vascular-Bone Axis in the Chronic Kidney Disease-Mineral Bone Disorder. Transplantation. 2016;100(3):497-505. PMCID:PMC4764429 PMID:26356179 Sugatani T, Agapova O, Malluche HH, Hruska KA. SIRT6 deficiency culminates in low-turnover osteopenia. Bone. 2015;81:168-77. PMCID:PMC4640951 PMID:26189760 Anyaegbu EI, Shaw AS, Hruska KA, Jain S. Clinical phenotype of APOL1 nephropathy in young relatives of patients with end-stage renal disease. Pediatr Nephrol. 2015;30(6):983-9. doi:10.1007/s00467-014-3031-0 PMCID:PMC4406792 PMID:25530085 Freedman BI, Divers J, Russell GB, Palmer ND, Bowden DW, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Langefeld CD, Hruska KA, Register TC. Plasma FGF23 and Calcified Atherosclerotic Plaque in African Americans with Type 2 Diabetes Mellitus. Am J Nephrol. 2015;42(6):391-401. doi:10.1159/000443241 PMCID:PMC4732898 PMID:26693712 Sugatani T, Hildreth BE 3rd, Toribio RE, Malluche HH, Hruska KA. Expression of DGCR8-dependent microRNAs is indispensable for osteoclastic development and bone-resorbing activity. J Cell Biochem. 2014;115(6):1043-7. doi:10.1002/jcb.24759 PMCID:PMCID: PMC4079251 PMID:24420069 Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI. Sclerostin is positively associated with bone mineral density in men and women and negatively associated with carotid calcified atherosclerotic plaque in men from the African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2014;99(1):315-21. doi:10.1210/jc.2013-3168 PMCID:PMC3879670 PMID:24178795 Seifert ME, de Las Fuentes L, Ginsberg C, Rothstein M, Dietzen DJ, Cheng SC, Ross W, Windus D, Dávila-Román VG, Hruska KA. Left ventricular mass progression despite stable blood pressure and kidney function in stage 3 chronic kidney disease. Am J Nephrol. 2014;39(5):392-9. doi:10.1159/000362251 PMCID:PMC4066883 PMID:24818573 Manson SR, Song JB, Hruska KA, Austin PF. HDAC dependent transcriptional repression of Bmp-7 potentiates TGF-β mediated renal fibrosis in obstructive uropathy. J Urol. 2014;191(1):242-52. doi:10.1016/j.juro.2013.06.110 PMCID:PMC4084877 PMID:23820056 Fang Y, Ginsberg C, Sugatani T, Monier-Faugere MC, Malluche H, Hruska KA. Early chronic kidney disease-mineral bone disorder stimulates vascular calcification. Kidney Int. 2014;85(1):142-50. doi:10.1038/ki.2013.271 PMCID:PMC3836911 PMID:23884339 Block GA, Ix JH, Ketteler M, Martin KJ, Thadhani RI, Tonelli M, Wolf M, Jüppner H, Hruska K, Wheeler DC. Phosphate homeostasis in CKD: report of a scientific symposium sponsored by the National Kidney Foundation. Am J Kidney Dis. 2013;62(3):457-73. doi:10.1053/j.ajkd.2013.03.042 PMID:23763855 Anyaegbu E, Davis TK, Kniska K, Hruska K, Beck A. Buyer beware! doctor be aware!: Questions. Pediatr Nephrol. 2013;28(9):1785; answer 1787-90. doi:10.1007/s00467-012-2338-y PMID:23111895 Sugatani T, Hruska KA. Down-regulation of miR-21 biogenesis by estrogen action contributes to osteoclastic apoptosis. J Cell Biochem. 2013;114(6):1217-22. doi:10.1002/jcb.24471 PMCID:PMCID: PMC4154486 PMID:23238785 Register TC, Divers J, Bowden DW, Carr JJ, Lenchik L, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Hruska KA, Langefeld CD, Freedman BI. Relationships between serum adiponectin and bone density, adiposity and calcified atherosclerotic plaque in the African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2013;98(5):1916-22. doi:10.1210/jc.2012-4126 PMCID:PMC3644610 PMID:23543659 Divers J, Palmer ND, Lu L, Register TC, Carr JJ, Hicks PJ, Hightower RC, Smith SC, Xu J, Cox AJ, Hruska KA, Bowden DW, Lewis CE, Heiss G, Province MA, Borecki IB, Kerr KF, Chen YD, Palmas W, Rotter JI, Wassel CL, Bertoni AG, Herrington DM, Wagenknecht LE, Langefeld CD, Freedman BI. Admixture mapping of coronary artery calcified plaque in African Americans with type 2 diabetes mellitus. Circ Cardiovasc Genet. 2013;6(1):97-105. doi:10.1161/CIRCGENETICS.112.964114 PMCID:PMC3578054 PMID:23233742 Seifert ME, de las Fuentes L, Rothstein M, Dietzen DJ, Bierhals AJ, Cheng SC, Ross W, Windus D, Dávila-Román VG, Hruska KA. Effects of phosphate binder therapy on vascular stiffness in early-stage chronic kidney disease. Am J Nephrol. 2013;38(2):158-67. doi:10.1159/000353569 PMID:23941761 Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI. Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes. J Clin Endocrinol Metab. 2013;98(1):E60-5. doi:10.1210/jc.2012-3038 PMCID:PMC3537092 PMID:23125289 Murea M, Register TC, Divers J, Bowden DW, Carr JJ, Hightower CR, Xu J, Smith SC, Hruska KA, Langefeld CD, Freedman BI. Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study. BMC Nephrol. 2012;13:148. doi:10.1186/1471-2369-13-148 PMCID:PMC3534523 PMID:23151275 Chatterjee R, Ramos E, Hoffman M, VanWinkle J, Martin DR, Davis TK, Hoshi M, Hmiel SP, Beck A, Hruska K, Coplen D, Liapis H, Mitra R, Druley T, Austin P, Jain S. Traditional and targeted exome sequencing reveals common, rare and novel functional deleterious variants in RET-signaling complex in a cohort of living US patients with urinary tract malformations. Hum Genet. 2012;131(11):1725-38. doi:10.1007/s00439-012-1181-3 PMCID:PMC3551468 PMID:22729463 Manson SR, Niederhoff RA, Hruska KA, Austin PF. Endogenous BMP-7 is a critical molecular determinant of the reversibility of obstruction-induced renal injuries. Am J Physiol Renal Physiol. 2011;301(6):F1293-302. doi:10.1152/ajprenal.00071.2011 PMCID:PMC3774217 PMID:21880836 Siedlecki AM, Jin X, Thomas W, Hruska KA, Muslin AJ. RGS4, a GTPase activator, improves renal function in ischemia-reperfusion injury. Kidney Int. 2011;80(3):263-71. doi:10.1038/ki.2011.63 PMCID:PMC3221244 PMID:21412219 Divers J, Register TC, Langefeld CD, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Xu J, Hruska KA, Freedman BI. Relationships between calcified atherosclerotic plaque and bone mineral density in African Americans with type 2 diabetes. J Bone Miner Res. 2011;26(7):1554-60. doi:10.1002/jbmr.389 PMID:21437982 Manson SR, Niederhoff RA, Hruska KA, Austin PF. The BMP-7-Smad1/5/8 pathway promotes kidney repair after obstruction induced renal injury. J Urol. 2011;185(6 Suppl):2523-30. doi:10.1016/j.juro.2011.01.034 PMCID:PMC3418146 PMID:21527199 London G, Coyne D, Hruska K, Malluche HH, Martin KJ. The new kidney disease: improving global outcomes (KDIGO) guidelines - expert clinical focus on bone and vascular calcification. Clin Nephrol. 2010;74(6):423-32. PMCID:PMC3770279 PMID:21084045 Hruska KA, Choi ET, Memon I, Davis TK, Mathew S. Cardiovascular risk in chronic kidney disease (CKD): the CKD-mineral bone disorder (CKD-MBD). Pediatr Nephrol. 2010;25(4):769-78. doi:10.1007/s00467-009-1337-0 PMCID:PMC3719392 PMID:19898875 Teti A, Grano M, Colucci S, Argentino L, Barattolo R, Miyauchi A, Teitelbaum SL, Hruska KA, Zambonin-Zallone A. Voltage dependent calcium channel expression in isolated osteoclasts Boll Soc Ital Biol Sper. 2009;65(12):1115-1118.
Freedman BI, Bowden DW, Ziegler JT, Langefeld CD, Lehtinen AB, Rudock ME, Lenchik L, Hruska KA, Register TC, Carr JJ. Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study. J Bone Miner Res. 2009;24(10):1719-27. doi:10.1359/jbmr.090501 PMCID:PMC2743282 PMID:19453255 Kokubo T, Ishikawa N, Uchida H, Chasnoff SE, Xie X, Mathew S, Hruska KA, Choi ET. CKD accelerates development of neointimal hyperplasia in arteriovenous fistulas. J Am Soc Nephrol. 2009;20(6):1236-45. doi:10.1681/ASN.2007121312 PMCID:PMC2689906 PMID:19423694 Hruska KA, Mathew S, Lund RJ, Memon I, Saab G. The pathogenesis of vascular calcification in the chronic kidney disease mineral bone disorder: the links between bone and the vasculature. Semin Nephrol. 2009;29(2):156-65. doi:10.1016/j.semnephrol.2009.01.008 PMCID:PMC2758096 PMID:19371806 Mathew S, Lund RJ, Chaudhary LR, Geurs T, Hruska KA. Vitamin D receptor activators can protect against vascular calcification. J Am Soc Nephrol. 2008;19(8):1509-19. doi:10.1681/ASN.2007080902 PMCID:PMC2488263 PMID:18448587 Mathew S, Tustison KS, Sugatani T, Chaudhary LR, Rifas L, Hruska KA. The mechanism of phosphorus as a cardiovascular risk factor in CKD. J Am Soc Nephrol. 2008;19(6):1092-105. doi:10.1681/ASN.2007070760 PMCID:PMC2396927 PMID:18417722 Hruska KA, Mathew S, Lund R. Osteoporosis and cardiovascular disease: lessons from chronic kidney disease. Clin Cases Miner Bone Metab. 2008;5(1):35-9. PMCID:PMC2781186 PMID:22460843 De Petris L, Hruska KA, Chiechio S, Liapis H. Bone morphogenetic protein-7 delays podocyte injury due to high glucose. Nephrol Dial Transplant. 2007;22(12):3442-50. doi:10.1093/ndt/gfm503 PMID:17686813 Sugatani T, Hruska KA. MicroRNA-223 is a key factor in osteoclast differentiation. J Cell Biochem. 2007;101(4):996-9. doi:10.1002/jcb.21335 PMID:17471500 Hruska KA, Saab G, Mathew S, Lund R. Renal osteodystrophy, phosphate homeostasis, and vascular calcification. Semin Dial. 2007;20(4):309-15. PMID:17635820 Mathew S, Lund RJ, Strebeck F, Tustison KS, Geurs T, Hruska KA. Reversal of the adynamic bone disorder and decreased vascular calcification in chronic kidney disease by sevelamer carbonate therapy. J Am Soc Nephrol. 2007;18(1):122-30. doi:10.1681/ASN.2006050490 PMID:17182886 Mathew S, Davies M, Lund R, Saab G, Hruska KA. Function and effect of bone morphogenetic protein-7 in kidney bone and the bone-vascular links in chronic kidney disease. Eur J Clin Invest. 2006;36 Suppl 2:43-50. doi:10.1111/j.1365-2362.2006.01663.x PMID:16884397 Hendy GN, Hruska KA, Mathew S, Goltzman D. New insights into mineral and skeletal regulation by active forms of vitamin D. Kidney Int. 2006;69(2):218-23. doi:10.1038/sj.ki.5000091 PMID:16408109 Lund RJ, Davies MR, Mathew S, Hruska KA. New discoveries in the pathogenesis of renal osteodystrophy. J Bone Miner Metab. 2006;24(2):169-71. doi:10.1007/s00774-005-0666-8 PMID:16502127 Hruska KA, Mathew S, Davies MR, Lund RJ. Connections between vascular calcification and progression of chronic kidney disease: therapeutic alternatives. Kidney Int Suppl. 2005;(99):S142-51. doi:10.1111/j.1523-1755.2005.09926.x PMID:16336568 Surendran K, Schiavi S, Hruska KA. Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol. 2005;16(8):2373-84. doi:10.1681/ASN.2004110949 PMID:15944336 Jendrisak MD, Hruska K, Wagner J, Chandler D, Kappel D. Hospital-independent organ recovery from deceased donors: a two-year experience. Am J Transplant. 2005;5(5):1105-10. doi:10.1111/j.1600-6143.2005.00804.x PMID:15816893 Davies MR, Lund RJ, Mathew S, Hruska KA. Low turnover osteodystrophy and vascular calcification are amenable to skeletal anabolism in an animal model of chronic kidney disease and the metabolic syndrome. J Am Soc Nephrol. 2005;16(4):917-28. doi:10.1681/ASN.2004100835 PMID:15743994 Sugatani T, Hruska KA. Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors. J Biol Chem. 2005;280(5):3583-9. doi:10.1074/jbc.M410480200 PMID:15545269 Lu Y, Adkisson HD, Bogdanske J, Kalscheur V, Maloney W, Cheung R, Grodzinsky AJ, Hruska KA, Markel MD. In vivo transplantation of neonatal ovine neocartilage allografts: determining the effectiveness of tissue transglutaminase. J Knee Surg. 2005;18(1):31-42. PMID:15742595 Li T, Surendran K, Zawaideh MA, Mathew S, Hruska KA. Bone morphogenetic protein 7: a novel treatment for chronic renal and bone disease. Curr Opin Nephrol Hypertens. 2004;13(4):417-22. PMID:15199292 Biswas RS, Baker D, Hruska KA, Chellaiah MA. Polyphosphoinositides-dependent regulation of the osteoclast actin cytoskeleton and bone resorption. BMC Cell Biol. 2004;5:19. doi:10.1186/1471-2121-5-19 PMCID:PMC441372 PMID:15142256 Goodman WG, London G, Amann K, Block GA, Giachelli C, Hruska KA, Ketteler M, Levin A, Massy Z, McCarron DA, Raggi P, Shanahan CM, Yorioka N, Vascular Calcification Work Group. Vascular calcification in chronic kidney disease. Am J Kidney Dis. 2004;43(3):572-9. PMID:14981617 Chaudhary LR, Hofmeister AM, Hruska KA. Differential growth factor control of bone formation through osteoprogenitor differentiation. Bone. 2004;34(3):402-11. doi:10.1016/j.bone.2003.11.014 PMID:15003788 Lund RJ, Davies MR, Brown AJ, Hruska KA. Successful treatment of an adynamic bone disorder with bone morphogenetic protein-7 in a renal ablation model. J Am Soc Nephrol. 2004;15(2):359-69. PMID:14747382 Nochi H, Sung JH, Lou J, Adkisson HD, Maloney WJ, Hruska KA. Adenovirus mediated BMP-13 gene transfer induces chondrogenic differentiation of murine mesenchymal progenitor cells. J Bone Miner Res. 2004;19(1):111-22. doi:10.1359/jbmr.2004.19.1.111 PMID:14753743 Hruska KA, Saab G, Chaudhary LR, Quinn CO, Lund RJ, Surendran K. Kidney-bone, bone-kidney, and cell-cell communications in renal osteodystrophy. Semin Nephrol. 2004;24(1):25-38. PMID:14730507 Walling HW, Raggatt LJ, Irvine DW, Barmina OY, Toledano JE, Goldring MB, Hruska KA, Adkisson HD, Burdge RE, Gatt CJ Jr, Harwood DA, Partridge NC. Impairment of the collagenase-3 endocytotic receptor system in cells from patients with osteoarthritis. Osteoarthritis Cartilage. 2003;11(12):854-63. PMID:14629961 Sugatani T, Alvarez UM, Hruska KA. Activin A stimulates IkappaB-alpha/NFkappaB and RANK expression for osteoclast differentiation, but not AKT survival pathway in osteoclast precursors. J Cell Biochem. 2003;90(1):59-67. doi:10.1002/jcb.10613 PMID:12938156 Chellaiah MA, Biswas RS, Rittling SR, Denhardt DT, Hruska KA. Rho-dependent Rho kinase activation increases CD44 surface expression and bone resorption in osteoclasts. J Biol Chem. 2003;278(31):29086-97. doi:10.1074/jbc.M211074200 PMID:12730217 Wang S, Chen Q, Simon TC, Strebeck F, Chaudhary L, Morrissey J, Liapis H, Klahr S, Hruska KA. Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy. Kidney Int. 2003;63(6):2037-49. doi:10.1046/j.1523-1755.2003.00035.x PMID:12753291 Davies MR, Lund RJ, Hruska KA. BMP-7 is an efficacious treatment of vascular calcification in a murine model of atherosclerosis and chronic renal failure. J Am Soc Nephrol. 2003;14(6):1559-67. PMID:12761256 Rojas E, Carlini RG, Clesca P, Arminio A, Suniaga O, De Elguezabal K, Weisinger JR, Hruska KA, Bellorin-Font E. The pathogenesis of osteodystrophy after renal transplantation as detected by early alterations in bone remodeling. Kidney Int. 2003;63(5):1915-23. doi:10.1046/j.1523-1755.2003.00938.x PMID:12675872 Chaudhary LR, Hruska KA. Inhibition of cell survival signal protein kinase B/Akt by curcumin in human prostate cancer cells. J Cell Biochem. 2003;89(1):1-5. doi:10.1002/jcb.10495 PMID:12682902 Saab G, Mathew S, Chaudhary LR, Hruska KA. Post-transplant osteodystrophy in the era of the K/DOQI guidelines. Dialysis & Transplantation. 2003;32:651-658.
Gupta A, Lee BS, Khadeer MA, Tang Z, Chellaiah M, Abu-Amer Y, Goldknopf J, Hruska KA. Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast. J Bone Miner Res. 2003;18(4):669-85. doi:10.1359/jbmr.2003.18.4.669 PMID:12674328 Chellaiah MA, Hruska KA. The integrin alpha(v)beta(3) and CD44 regulate the actions of osteopontin on osteoclast motility. Calcif Tissue Int. 2003;72(3):197-205. doi:10.1007/s00223-002-1025-6 PMID:12469249 Sugatani T, Alvarez U, Hruska KA. PTEN regulates RANKL- and osteopontin-stimulated signal transduction during osteoclast differentiation and cell motility. J Biol Chem. 2003;278(7):5001-8. doi:10.1074/jbc.M209299200 PMID:12460992 Uchida K, Chaudhary LR, Sugimura Y, Adkisson HD, Hruska KA. Proprotein convertases regulate activity of prostate epithelial cell differentiation markers and are modulated in human prostate cancer cells. J Cell Biochem. 2003;88(2):394-9. doi:10.1002/jcb.10327 PMID:12520542 Chellaiah MA, Kizer N, Biswas R, Alvarez U, Strauss-Schoenberger J, Rifas L, Rittling SR, Denhardt DT, Hruska KA. Osteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expression. Mol Biol Cell. 2003;14(1):173-89. doi:10.1091/mbc.E02-06-0354 PMCID:PMC140236 PMID:12529435 Jendrisak MD, Hruska K, Wagner J, Chandler D, Kappel D. Cadaveric-donor organ recovery at a hospital-independent facility. Transplantation. 2002;74(7):978-82. PMID:12394841 Klahr S, Morrissey J, Hruska K, Wang S, Chen Q. New approaches to delay the progression of chronic renal failure. Kidney Int Suppl. 2002;(80):23-6. doi:10.1046/j.1523-1755.61.s80.16.x PMID:11982808 González EA, Lund RJ, Martin KJ, McCartney JE, Tondravi MM, Sampath TK, Hruska KA. Treatment of a murine model of high-turnover renal osteodystrophy by exogenous BMP-7. Kidney Int. 2002;61(4):1322-31. doi:10.1046/j.1523-1755.2002.00258.x PMID:11918739 Morrissey J, Hruska K, Guo G, Wang S, Chen Q, Klahr S. Bone morphogenetic protein-7 improves renal fibrosis and accelerates the return of renal function. J Am Soc Nephrol. 2002;13 Suppl 1:S14-21. PMID:11792757 Lund RJ, Davies MR, Hruska KA. Bone morphogenetic protein-7: an anti-fibrotic morphogenetic protein with therapeutic importance in renal disease. Curr Opin Nephrol Hypertens. 2002;11(1):31-6. PMID:11753084 Chellaiah MA, Biswas RS, Yuen D, Alvarez UM, Hruska KA. Phosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolin. J Biol Chem. 2001;276(50):47434-44. doi:10.1074/jbc.M107494200 PMID:11577104 Gupta A, Tenenhouse HS, Hoag HM, Wang D, Khadeer MA, Namba N, Feng X, Hruska KA. Identification of the type II Na(+)-Pi cotransporter (Npt2) in the osteoclast and the skeletal phenotype of Npt2-/- mice. Bone. 2001;29(5):467-76. PMID:11704500 Adkisson HD, Gillis MP, Davis EC, Maloney W, Hruska KA. In vitro generation of scaffold independent neocartilage. Clin Orthop Relat Res. 2001;(391 Suppl):S280-94. PMID:11603712 Soga N, Namba N, McAllister S, Cornelius L, Teitelbaum SL, Dowdy SF, Kawamura J, Hruska KA. Rho family GTPases regulate VEGF-stimulated endothelial cell motility. Exp Cell Res. 2001;269(1):73-87. doi:10.1006/excr.2001.5295 PMID:11525641 Vocero-Akbari, A., Chellaiah, M.A., Hruska, K.A., Dowdy, S.F. Protein transduction: delivery of Tat-GTPase fusion proteins into mammalian cells Methods Enzymol. 2001;332:36-49.
Bennett BD, Alvarez U, Hruska KA. Receptor-operated osteoclast calcium sensing. Endocrinology. 2001;142(5):1968-74. doi:10.1210/endo.142.5.8125 PMID:11316762 Ihara H, Denhardt DT, Furuya K, Yamashita T, Muguruma Y, Tsuji K, Hruska KA, Higashio K, Enomoto S, Nifuji A, Rittling SR, Noda M. Parathyroid hormone-induced bone resorption does not occur in the absence of osteopontin. J Biol Chem. 2001;276(16):13065-71. doi:10.1074/jbc.M010938200 PMID:11278791 Chaudhary LR, Hruska KA. The cell survival signal Akt is differentially activated by PDGF-BB, EGF, and FGF-2 in osteoblastic cells. J Cell Biochem. 2001;81(2):304-11. PMID:11241670 Soga N, Connolly JO, Chellaiah M, Kawamura J, Hruska KA. Rac regulates vascular endothelial growth factor stimulated motility. Cell Commun Adhes. 2001;8(1):1-13. PMID:11775025 Wozniak M, Fausto A, Carron CP, Meyer DM, Hruska KA. Mechanically strained cells of the osteoblast lineage organize their extracellular matrix through unique sites of alphavbeta3-integrin expression. J Bone Miner Res. 2000;15(9):1731-45. doi:10.1359/jbmr.2000.15.9.1731 PMID:10976993 Schwarze SR, Hruska KA, Dowdy SF. Protein transduction: unrestricted delivery into all cells? Trends Cell Biol. 2000;10(7):290-5. PMID:10856932 Hruska KA, Guo G, Wozniak M, Martin D, Miller S, Liapis H, Loveday K, Klahr S, Sampath TK, Morrissey J. Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction. Am J Physiol Renal Physiol. 2000;279(1):F130-43. PMID:10894795 Civitelli R, Hruska K, Ralston S. Dawning of a New Era at CTI Calcif Tissue Int. 2000;67(1):1. PMID:10908404 Hruska KA. Pathophysiology of renal osteodystrophy Pediatr Nephrol. 2000;14:636-640.
Adkisson HD, Strauss-Schoenberger J, Gillis M, Wilkins R, Jackson M, Hruska KA. Rapid quantitative bioassay of osteoinduction. J Orthop Res. 2000;18(3):503-11. doi:10.1002/jor.1100180326 PMID:10937641 Connolly JO, Soga N, Guo XL, Alvarez U, Hruska KA. Rac is essential in the transformation of endothelial cells by polyoma middle T. Cell Adhes Commun. 2000;7(5):409-22. PMID:10830619 Chellaiah MA, Soga N, Swanson S, McAllister S, Alvarez U, Wang D, Dowdy SF, Hruska KA. Rho-A is critical for osteoclast podosome organization, motility, and bone resorption. J Biol Chem. 2000;275(16):11993-2002. PMID:10766830 Cheng SL, Lai CF, Fausto A, Chellaiah M, Feng X, McHugh KP, Teitelbaum SL, Civitelli R, Hruska KA, Ross FP, Avioli LV. Regulation of alphaVbeta3 and alphaVbeta5 integrins by dexamethasone in normal human osteoblastic cells. J Cell Biochem. 2000;77(2):265-76. PMID:10723092 Chellaiah M, Kizer N, Silva M, Alvarez U, Kwiatkowski D, Hruska KA. Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength. J Cell Biol. 2000;148(4):665-78. PMCID:PMC2169374 PMID:10684249 Hruska KA. New insights related to aging and renal osteodystrophy. Geriatr Nephrol Urol. 1999;9(1):49-56. PMID:10435227 Kizer N, Harter L, Hruska K, Alvarez U, Duncan R. Volume regulatory decrease in UMR-106.01 cells is mediated by specific alpha1 subunits of L-type calcium channels. Cell Biochem Biophys. 1999;31(1):65-79. doi:10.1007/BF02738155 PMID:10505668 Chellaiah MA, Hruska KA. Osteopontin. Drug News Perspect. 1998;11(6):350-5. PMID:15616623 Powell T, Hsu FF, Turk J, Hruska K. Ma-huang strikes again: ephedrine nephrolithiasis. Am J Kidney Dis. 1998;32(1):153-9. PMID:9669437 Stickle D, Cole B, Hock K, Hruska KA, Scott MG. Correlation of plasma concentrations of cystatin C and creatinine to inulin clearance in a pediatric population. Clin Chem. 1998;44(6 Pt 1):1334-8. PMID:9625061 Chellaiah M, Fitzgerald C, Alvarez U, Hruska K. c-Src is required for stimulation of gelsolin-associated phosphatidylinositol 3-kinase. J Biol Chem. 1998;273(19):11908-16. PMID:9565618 Teti A, Taranta A, Migliaccio S, Degiorgi A, Santandrea E, Villanova I, Faraggiana T, Chellaiah M, Hruska KA. Colony stimulating factor-1-induced osteoclast spreading depends on substrate and requires the vitronectin receptor and the c-src proto-oncogene. J Bone Miner Res. 1998;13(1):50-8. doi:10.1359/jbmr.1998.13.1.50 PMID:9443790 Onishi T, Zhang W, Cao X, Hruska K. The mitogenic effect of parathyroid hormone is associated with E2F-dependent activation of cyclin-dependent kinase 1 (cdc2) in osteoblast precursors. J Bone Miner Res. 1997;12(10):1596-605. doi:10.1359/jbmr.1997.12.10.1596 PMID:9333120 Rifas L, Cheng S, Halstead LR, Gupta A, Hruska KA, Avioli LV. Skeletal casein kinase activity defect in the HYP mouse. Calcif Tissue Int. 1997;61(3):256-9. PMID:9262518 Gupta A, Guo XL, Alvarez UM, Hruska KA. Regulation of sodium-dependent phosphate transport in osteoclasts. J Clin Invest. 1997;100(3):538-49. doi:10.1172/JCI119563 PMCID:PMC508220 PMID:9239400 Endsley JK, Phillips JA 3rd, Hruska KA, Denneberg T, Carlson J, George AL Jr. Genomic organization of a human cystine transporter gene (SLC3A1) and identification of novel mutations causing cystinuria. Kidney Int. 1997;51(6):1893-9. PMID:9186880 Onishi T, Hruska K. Expression of p27Kip1 in osteoblast-like cells during differentiation with parathyroid hormone. Endocrinology. 1997;138(5):1995-2004. doi:10.1210/endo.138.5.5146 PMID:9112398 Hruska KA. Renal osteodystrophy. Baillieres Clin Endocrinol Metab. 1997;11(1):165-94. PMID:9222491 Rogers SA, Padanilam BJ, Hruska KA, Giachelli CM, Hammerman MR. Metanephric osteopontin regulates nephrogenesis in vitro. Am J Physiol. 1997;272(4 Pt 2):F469-76. PMID:9140047 Kizer N, Guo XL, Hruska K. Reconstitution of stretch-activated cation channels by expression of the alpha-subunit of the epithelial sodium channel cloned from osteoblasts. Proc Natl Acad Sci U S A. 1997;94(3):1013-8. PMCID:PMC19631 PMID:9023374 Kim YS, MacDonald PN, Dedhar S, Hruska KA. Association of 1 alpha,25-dihydroxyvitamin D3-occupied vitamin D receptors with cellular membrane acceptance sites. Endocrinology. 1996;137(9):3649-58. doi:10.1210/endo.137.9.8756529 PMID:8756529 Chellaiah M, Fitzgerald C, Filardo EJ, Cheresh DA, Hruska KA. Osteopontin activation of c-src in human melanoma cells requires the cytoplasmic domain of the integrin alpha v-subunit. Endocrinology. 1996;137(6):2432-40. doi:10.1210/endo.137.6.8641196 PMID:8641196 Chellaiah M, Hruska K. Osteopontin stimulates gelsolin-associated phosphoinositide levels and phosphatidylinositol triphosphate-hydroxyl kinase. Mol Biol Cell. 1996;7(5):743-53. PMCID:PMC275927 PMID:8744948 Gupta A, Miyauchi A, Fujimori A, Hruska KA. Phosphate transport in osteoclasts: a functional and immunochemical characterization. Kidney Int. 1996;49(4):968-74. PMID:8691746 Duncan RL, Kizer N, Barry EL, Friedman PA, Hruska KA. Antisense oligodeoxynucleotide inhibition of a swelling-activated cation channel in osteoblast-like osteosarcoma cells. Proc Natl Acad Sci U S A. 1996;93(5):1864-9. PMCID:PMC39873 PMID:8700850 Gupta A, Edwards JC, Hruska KA. Cellular distribution and regulation of NHE-1 isoform of the NA-H exchanger in the avian osteoclast. Bone. 1996;18(2):87-95. PMID:8833201 Rifas L, Gupta A, Hruska KA, Avioli LV. Altered osteoblast gluconeogenesis in X-linked hypophosphatemic mice is associated with a depressed intracellular pH. Calcif Tissue Int. 1995;57(1):60-3. PMID:7671167 Hruska KA, Rolnick F, Huskey M, Alvarez U, Cheresh D. Engagement of the osteoclast integrin alpha v beta 3 by osteopontin stimulates phosphatidylinositol 3-hydroxyl kinase activity. Ann N Y Acad Sci. 1995;760:151-65. PMID:7540372 Hruska KA, Rifas L, Cheng SL, Gupta A, Halstead L, Avioli L. X-linked hypophosphatemic rickets and the murine Hyp homologue. Am J Physiol. 1995;268(3 Pt 2):F357-62. PMID:7900834 Harter LV, Hruska KA, Duncan RL. Human osteoblast-like cells respond to mechanical strain with increased bone matrix protein production independent of hormonal regulation. Endocrinology. 1995;136(2):528-35. doi:10.1210/endo.136.2.7530647 PMID:7530647 Hruska KA, Chellaiah M, Rolnick F, Yamakawa K, Gupta A. Recent progress in signal transduction related to bone remodeling and aging. Calcif Tissue Int. 1995;56 Suppl 1:S35-8. doi:10.1007/BF03354651 PMID:25773034 Hruska KA, Chellaiah M, Rolnick F, Yamakawa K, Gupta A. Recent progress in signal transduction related to bone remodeling and aging. Calcif Tissue Int. 1995;56 Suppl 1:S35-8. doi:10.1007/BF03354651 PMID:25773034 Duncan RL, Hruska KA. Chronic, intermittent loading alters mechanosensitive channel characteristics in osteoblast-like cells. Am J Physiol. 1994;267(6 Pt 2):F909-16. PMID:7528987 Gupta A, Hruska KA, Tuan TL. Angiotensin II binding to human embryonic lung fibroblasts causes transient changes in cytosolic calcium and promotes fibrin gel contraction. Indian J Exp Biol. 1994;32(9):603-6. PMID:7814036 Gupta A, Hruska KA, Martin KJ. Neurotensin binding to human embryonic lung fibroblasts. J Recept Res. 1994;14(5):307-17. PMID:7815388 Yamakawa K, Duncan R, Hruska KA. An Arg-Gly-Asp peptide stimulates Ca2+ efflux from osteoclast precursors through a novel mechanism. Am J Physiol. 1994;266(4 Pt 2):F651-7. PMID:8184899 Fujimori A, Miyauchi A, Hruska KA, Martin KJ, Avioli LV, Civitelli R. Desensitization of calcium messenger system in parathyroid hormone-stimulated opossum kidney cells. Am J Physiol. 1993;264(6 Pt 1):E918-24. PMID:8392807 Medhora MM, Teitelbaum S, Chappel J, Alvarez J, Mimura H, Ross FP, Hruska K. 1 alpha,25-dihydroxyvitamin D3 up-regulates expression of the osteoclast integrin alpha v beta 3. J Biol Chem. 1993;268(2):1456-61. PMID:7678259 Duncan RL, Hruska KA, Misler S. Parathyroid hormone activation of stretch-activated cation channels in osteosarcoma cells (UMR-106.01). FEBS Lett. 1992;307(2):219-23. PMID:1379539 Moskowitz DW, Hruska KA. Ca2+ uptake by endoplasmic reticulum of renal cortex. II. Effects of uninephrectomy and parathyroidectomy. Calcif Tissue Int. 1992;51(1):42-7. PMID:1393776 Moskowitz DW, Hruska KA. Ca2+ uptake by endoplasmic reticulum of renal cortex. I. Ionic requirements and regulation in vitro. Calcif Tissue Int. 1992;51(1):35-41. PMID:1327465 Hardy RW, Ladenson JH, Hruska KA, Jiwa AH, McDonald JM. The effects of extracellular calcium and epinephrine on cytosolic-free calcium in single rat adipocytes. Endocrinology. 1992;130(6):3694-702. doi:10.1210/endo.130.6.1597165 PMID:1597165 Civitelli R, Fujimori A, Bernier SM, Warlow PM, Goltzman D, Hruska KA, Avioli LV. Heterogeneous intracellular free calcium responses to parathyroid hormone correlate with morphology and receptor distribution in osteogenic sarcoma cells. Endocrinology. 1992;130(4):2392-400. doi:10.1210/endo.130.4.1312456 PMID:1312456 Gupta A, Bastani B, Chardin P, Hruska KA. Localization of ral, a small Mr GTP-binding protein, to collecting duct cells in bovine and rat kidney. Am J Physiol. 1991;261(6 Pt 2):F1063-70. PMID:1750519 Miyauchi A, Alvarez J, Greenfield EM, Teti A, Grano M, Colucci S, Zambonin-Zallone A, Ross FP, Teitelbaum SL, Cheresh D. Recognition of osteopontin and related peptides by an alpha v beta 3 integrin stimulates immediate cell signals in osteoclasts. J Biol Chem. 1991;266(30):20369-74. PMID:1939092 Allon M, Hruska KA. Renal adaptation to dietary phosphate restriction in rats. Interactions with insulin and calcitriol. Diabetes. 1991;40(9):1134-40. PMID:1936621 Gupta A, Bastani B, Purcell H, Hruska KA. Identification and localization of pertussis toxin-sensitive GTP-binding proteins in bovine kidney glomeruli. J Am Soc Nephrol. 1991;2(2):172-8. PMID:1954330 Tanaka H, Hruska KA, Seino Y, Malone JD, Nishii Y, Teitelbaum SL. Disassociation of the macrophage-maturational effects of vitamin D from respiratory burst priming. J Biol Chem. 1991;266(17):10888-92. PMID:1645714 Gupta A, Martin KJ, Miyauchi A, Hruska KA. Regulation of cytosolic calcium by parathyroid hormone and oscillations of cytosolic calcium in fibroblasts from normal and pseudohypoparathyroid patients. Endocrinology. 1991;128(6):2825-36. doi:10.1210/endo-128-6-2825 PMID:1645251 Obialo CI, Clayman RV, Matts JP, Fitch LL, Buchwald H, Gillis M, Hruska KA. Pathogenesis of nephrolithiasis post-partial ileal bypass surgery: case-control study. The POSCH Group. Kidney Int. 1991;39(6):1249-54. PMID:1895677 Civitelli R, Hruska KA. Monitoring cytosolic calcium in renal epithelia. Special issue "Methods in Kidney Epithelial Cell Culture" J Tiss Cul Methods. 1991;13:217-228.
Hruska KA, Civitelli R, Duncan R, Avioli LV. Regulation of skeletal remodeling by parathyroid hormone. Contrib Nephrol. 1991;91:38-42. PMID:1800010 Miyauchi A, Hruska KA, Greenfield EM, Duncan R, Alvarez J, Barattolo R, Colucci S, Zambonin-Zallone A, Teitelbaum SL, Teti A. Osteoclast cytosolic calcium, regulated by voltage-gated calcium channels and extracellular calcium, controls podosome assembly and bone resorption. J Cell Biol. 1990;111(6 Pt 1):2543-52. PMCID:PMC2116358 PMID:1703539 Rothstein M, Obialo C, Hruska KA. Renal tubular acidosis. Endocrinol Metab Clin North Am. 1990;19(4):869-87. PMID:2081516 Civitelli R, Kim YS, Gunsten SL, Fujimori A, Huskey M, Avioli LV, Hruska KA. Nongenomic activation of the calcium message system by vitamin D metabolites in osteoblast-like cells. Endocrinology. 1990;127(5):2253-62. doi:10.1210/endo-127-5-2253 PMID:2226314 Miyauchi A, Dobre V, Rickmeyer M, Cole J, Forte L, Hruska KA. Stimulation of transient elevations in cytosolic Ca2+ is related to inhibition of Pi transport in OK cells. Am J Physiol. 1990;259(3 Pt 2):F485-93. PMID:2396674 Gupta A, Hruska KA, Wedner HJ. Phytohemagglutinin rapidly lyses S49 T-lymphoma cells and the cytotoxicity is not mediated by generation of cAMP or increase in cytosolic calcium. Biochem Biophys Res Commun. 1990;170(3):1035-43. PMID:2167667 Pacifici R, Rothstein M, Rifas L, Lau KH, Baylink DJ, Avioli LV, Hruska K. Increased monocyte interleukin-1 activity and decreased vertebral bone density in patients with fasting idiopathic hypercalciuria. J Clin Endocrinol Metab. 1990;71(1):138-45. doi:10.1210/jcem-71-1-138 PMID:2370292 Dunlay R, Hruska K. PTH receptor coupling to phospholipase C is an alternate pathway of signal transduction in bone and kidney. Am J Physiol. 1990;258(2 Pt 2):F223-31. PMID:2155534 Civitelli R, Hruska KA, Shen V, Avioli LV. Cyclic AMP-dependent and calcium-dependent signals in parathyroid hormone function. Exp Gerontol. 1990;25(3-4):223-31. PMID:2171968 Teitelbaum SL, Hruska KA. 1,25-Dihydroxycholecalciferol and macrophage differentiation with aging. Exp Gerontol. 1990;25(3-4):233-8. PMID:2171969 Civitelli R, Teitelbaum SL, Hruska KA, Lacey DL. IL-1 activates the Na+/H+ antiport in a murine T cell. J Immunol. 1989;143(12):4000-8. PMID:2556473 Teti A, Grano M, Colucci S, Argentino L, Barattolo R, Miyauchi A, Teitelbaum SL, Hruska KA, Zambonin Zallone A. Voltage dependent calcium channel expression in isolated osteoclasts. Boll Soc Ital Biol Sper. 1989;65(12):1115-8. PMID:2560636 Teti A, Barattolo R, Grano M, Colucci S, Argentino L, Teitelbaum SL, Hruska KA, Santacroce G, Zambonin Zallone A. Podosome expression in osteoclasts: influence of high extracellular calcium concentration. Boll Soc Ital Biol Sper. 1989;65(11):1039-43. PMID:2629823 Teti A, Blair HC, Schlesinger P, Grano M, Zambonin-Zallone A, Kahn AJ, Teitelbaum SL, Hruska KA. Extracellular protons acidify osteoclasts, reduce cytosolic calcium, and promote expression of cell-matrix attachment structures. J Clin Invest. 1989;84(3):773-80. doi:10.1172/JCI114235 PMCID:PMC329718 PMID:2547838 Civitelli R, Martin TJ, Fausto A, Gunsten SL, Hruska KA, Avioli LV. Parathyroid hormone-related peptide transiently increases cytosolic calcium in osteoblast-like cells: comparison with parathyroid hormone. Endocrinology. 1989;125(3):1204-10. doi:10.1210/endo-125-3-1204 PMID:2503365 Teti A, Grano M, Teitelbaum SL, Hruska KA, Colucci S, Zambonin Zallone A. Intracellular acidification induces decrease of cytosolic calcium in isolated osteoclasts. Boll Soc Ital Biol Sper. 1989;65(8):689-93. PMID:2803732 Karpinski E, Wu L, Civitelli R, Avioli LV, Hruska KA, Pang PK. A dihydropyridine-sensitive calcium channel in rodent osteoblastic cells. Calcif Tissue Int. 1989;45(1):54-7. PMID:2548684 Teti A, Grano M, Teitelbaum SL, Hruska KA, Colucci S, Zambonin Zallone A. Regulation of podosomes by intracellular pH in avian osteoclasts. Boll Soc Ital Biol Sper. 1989;65(7):597-601. PMID:2597415 Civitelli R, Hruska KA, Jeffrey JJ, Kahn AJ, Avioli LV, Partridge NC. Second messenger signaling in the regulation of collagenase production by osteogenic sarcoma cells. Endocrinology. 1989;124(6):2928-34. doi:10.1210/endo-124-6-2928 PMID:2542004 Suzuki Y, Hruska KA, Reid I, Alvarez UM, Avioli LV. Characterization of phospholipase C activity of the plasma membrane and cytosol of an osteoblast-like cell line. Am J Med Sci. 1989;297(3):135-44. PMID:2923133 Greenwald JE, Apkon M, Hruska KA, Needleman P. Stretch-induced atriopeptin secretion in the isolated rat myocyte and its negative modulation by calcium. J Clin Invest. 1989;83(3):1061-5. doi:10.1172/JCI113948 PMCID:PMC303784 PMID:2522102 Hruska KA, Bar-Shavit Z, Malone JD, Teitelbaum S. Ca2+ priming during vitamin D-induced monocytic differentiation of a human leukemia cell line. J Biol Chem. 1988;263(31):16039-44. PMID:3182781 Civitelli R, Reid IR, Westbrook S, Avioli LV, Hruska KA. PTH elevates inositol polyphosphates and diacylglycerol in a rat osteoblast-like cell line. Am J Physiol. 1988;255(5 Pt 1):E660-7. PMID:3263806 Scoble JE, Cragoe EJ Jr, Hruska KA. Na+-Ca2+ exchange and calcium permeability in canine basolateral membrane vesicles: the effects of dibutyryl cAMP and specific inhibitors. Biochim Biophys Acta. 1988;944(2):233-41. PMID:2846057 Filipponi P, Mannarelli C, Pacifici R, Grossi E, Moretti I, Tini S, Carloni C, Blass A, Morucci P, Hruska KA. Evidence for a prostaglandin-mediated bone resorptive mechanism in subjects with fasting hypercalciuria. Calcif Tissue Int. 1988;43(2):61-6. PMID:3142668 Reid IR, Civitelli R, Avioli LV, Hruska KA. Parathyroid hormone depresses cytosolic pH and DNA synthesis in osteoblast-like cells. Am J Physiol. 1988;255(1 Pt 1):E9-15. PMID:2839040 Goligorsky MS, Hruska KA. Hormonal modulation of cytoplasmic calcium concentration in renal tubular epithelium. Miner Electrolyte Metab. 1988;14(1):58-70. PMID:3279296 Shen V, Hruska K, Avioli LV. Characterization of a (Ca2+ + Mg2+)-ATPase system in the osteoblast plasma membrane. Bone. 1988;9(5):325-9. PMID:2974293 Goligorsky MS, Osborne D, Howard T, Hruska KA, Karl IE. Hormonal regulation of gluconeogenesis in cultured proximal tubular cells: role of cytosolic calcium. Am J Physiol. 1987;253(5 Pt 2):F802-9. PMID:3688237 Hruska KA. Regulation of renal phosphate reabsorption: concepts in evolution. Pediatr Nephrol. 1987;1(4):657-63. PMID:3153347 Reid IR, Civitelli R, Halstead LR, Avioli LV, Hruska KA. Parathyroid hormone acutely elevates intracellular calcium in osteoblastlike cells. Am J Physiol. 1987;253(1 Pt 1):E45-51. PMID:3037917 Civitelli R, Reid IR, Halstead LR, Avioli LV, Hruska KA. Membrane potential and cation content of osteoblast-like cells (UMR 106) assessed by fluorescent dyes. J Cell Physiol. 1987;131(3):434-41. doi:10.1002/jcp.1041310316 PMID:3474236 Reid IR, Civitelli R, Westbrook SL, Avioli LV, Hruska KA. Cytoplasmic pH regulation in canine renal proximal tubule cells. Kidney Int. 1987;31(5):1113-20. PMID:3599651 Bar-Shavit R, Hruska KA, Kahn AJ, Wilner GD. Thrombin chemotactic stimulation of HL-60 cells: studies on thrombin responsiveness as a function of differentiation. J Cell Physiol. 1987;131(2):255-61. doi:10.1002/jcp.1041310216 PMID:3034923 Goligorsky MS, Menton DN, Hruska KA. Effects of phorbol ester, cyclic nucleotides, and ionomycin on ion transport and brush-border topography in cultured renal proximal tubular cells. Ann NY Acad Sci. 1987;494 :208-210.
Martin KJ, Finch JL, Hruska K, Slatopolsky E. Effect of biological activity of PTH on its peripheral metabolism in the rat. Kidney Int. 1987;31(4):937-40. PMID:3586500 Suzuki Y, Fausto A, Hruska KA, Avioli LV. Stimulation of phosphatidylcholine biosynthesis in diabetic hypertrophic kidneys. Endocrinology. 1987;120(2):595-601. doi:10.1210/endo-120-2-595 PMID:3803292 Kurnik BR, Huskey M, Hruska KA. 1,25-Dihydroxycholecalciferol stimulates renal phosphate transport by directly altering membrane phosphatidylcholine composition. Biochim Biophys Acta. 1987;917(1):81-5. PMID:3790614 Hruska KA, Moskowitz D, Esbrit P, Civitelli R, Westbrook S, Huskey M. Stimulation of inositol trisphosphate and diacylglycerol production in renal tubular cells by parathyroid hormone. J Clin Invest. 1987;79(1):230-9. doi:10.1172/JCI112788 PMCID:PMC424029 PMID:3025260 Goligorsky MS, Duncan RL, Westbrook S, Reinach P, Hruska KA. Demonstration of a direct effect of atrial natriuretic factor on epithelium: study in cultured pig kidney cells. Miner Electrolyte Metab. 1987;13(1):51-6. PMID:2953957 Goligorsky MS, Loftus DJ, Hruska KA. Cytoplasmic calcium in individual proximal tubular cells in culture. Am J Physiol. 1986;251(5 Pt 2):F938-44. PMID:3777189 Goligorsky MS, Hruska KA, Loftus DJ, Elson EL. Alpha 1-adrenergic stimulation and cytoplasmic free calcium concentration in cultured renal proximal tubular cells: evidence for compartmentalization of quin-2 and fura-2. J Cell Physiol. 1986;128(3):466-74. doi:10.1002/jcp.1041280316 PMID:3755726 Hruska KA, Goligorsky M, Scoble J, Tsutsumi M, Westbrook S, Moskowitz D. Effects of parathyroid hormone on cytosolic calcium in renal proximal tubular primary cultures. Am J Physiol. 1986;251(2 Pt 2):F188-98. PMID:3740268 Kurnik BR, Huskey M, Hagerty D, Hruska KA. Vitamin D metabolites stimulate phosphatidylcholine transfer to renal brush-border membranes. Biochim Biophys Acta. 1986;858(1):47-55. PMID:3754768 Delmez JA, Fallon MD, Harter HR, Hruska KA, Slatopolsky E, Teitelbaum SL. Does strict phosphorus control precipitate renal osteomalacia? J Clin Endocrinol Metab. 1986;62(4):747-52. doi:10.1210/jcem-62-4-747 PMID:3949954 Shayman JA, Hruska KA, Morrison AR. Bradykinin stimulates increased intracellular calcium in papillary collecting tubules of the rabbit. Biochem Biophys Res Commun. 1986;134(1):299-304. PMID:3080988 Goligorsky MS, Menton DN, Hruska KA. Parathyroid hormone-induced changes of the brush border topography and cytoskeleton in cultured renal proximal tubular cells. J Membr Biol. 1986;92(2):151-62. PMID:3761360 Goligorsky MS, Hruska KA. Transcytosis in cultured proximal tubular cells. J Membr Biol. 1986;93(3):237-47. PMID:3820280 Scoble JE, Moskowitz D, Hruska KA. Dibutryladenosine 3',5'-cyclic monophosphate (dBcAMP) does not mimic the action of parathyroid hormone (PTH) on canine proximal tubular basolateral membrane Na+:Ca2+. Adv Exp Med Biol. 1986;208:537-41. PMID:3031954 Bar-Shavit R, Hruska KA, Kahn AJ, Wilner GD. Hormone-like activity of human thrombin. Ann N Y Acad Sci. 1986;485:335-48. PMID:3032049 Kurnik BR, Huskey M, Hruska KA. The direct effect of 1,25-dihydroxycholecalciferol on membrane phospholipid composition and phosphate transport. Adv Exp Med Biol. 1986;208:115-24. PMID:3565143 Kurnik BR, Hruska KA. Mechanism of stimulation of renal phosphate transport by 1,25-dihydroxycholecalciferol. Biochim Biophys Acta. 1985;817(1):42-50. PMID:3839137 Tsutsumi M, Alvarez U, Avioli LV, Hruska KA. Effect of 1,25-dihydroxyvitamin D3 on phospholipid composition of rat renal brush border membrane. Am J Physiol. 1985;249(1 Pt 2):F117-23. PMID:3839347 Scoble JE, Mills S, Hruska KA. Calcium transport in canine renal basolateral membrane vesicles. Effects of parathyroid hormone. J Clin Invest. 1985;75(4):1096-105. doi:10.1172/JCI111803 PMCID:PMC425432 PMID:3988932 Pohlman T, Hruska KA, Menon M. Renal tubular acidosis. J Urol. 1984;132(3):431-6. PMID:6471171 Kurnik BR, Hruska KA. Effects of 1,25-dihydroxycholecalciferol on phosphate transport in vitamin D-deprived rats. Am J Physiol. 1984;247(1 Pt 2):F177-84. PMID:6331201 Hruska KA, Khalifa S, Meltzer V, Martin K. Calcium as a mediator of the physiological and pathophysiological effects of parathyroid hormone. Semin Nephrol. 1984;4:159-173.
Khalifa S, Mills S, Hruska KA. Stimulation of calcium uptake by parathyroid hormone in renal brush-border membrane vesicles. Relationship to membrane phosphorylation. J Biol Chem. 1983;258(23):14400-6. PMID:6643490 Hruska KA, Mills SC, Khalifa S, Hammerman MR. Phosphorylation of renal brush-border membrane vesicles. Effect on calcium uptake and membrane content of polyphosphoinositides. J Biol Chem. 1983;258(4):2501-7. PMID:6296149 Hruska KA, Ban D, Avioli LV. Renal tubular acidosis. Arch Intern Med. 1982;142(10):1909-13. PMID:7125772 Cohn DE, Hruska KA, Klahr S, Hammerman MR. Increased Na+-H+ exchange in brush border vesicles from dogs with renal failure. Am J Physiol. 1982;243(3):F293-9. PMID:7114259 Meltzer V, Weinreb S, Bellorin-Font E, Hruska KA. Parathyroid hormone stimulation of renal phosphoinositide metabolism is a cyclic nucleotide-independent effect. Biochim Biophys Acta. 1982;712(2):258-67. PMID:6289907 Weinreb S, Hruska KA, Klahr S, Hammerman MR. Uptake of Pi in brush border vesicles after release of unilateral ureteral obstruction. Am J Physiol. 1982;243(1):F29-35. PMID:7046473 Cohen MA, Hruska KA, Daughaday WH. Free myo-inositol in canine kidneys: selective concentration in the renal medulla. Proc Soc Exp Biol Med. 1982;169(3):380-5. PMID:7063520 Slatopolsky E, Martin K, Morrissey J, Hruska K. Current concepts of the metabolism and radioimmunoassay of parathyroid hormone. J Lab Clin Med. 1982;99(3):309-16. PMID:7057058 Hammerman MR, Hruska KA. Cyclic AMP-dependent protein phosphorylation in canine renal brush-border membrane vesicles is associated with decreased phosphate transport. J Biol Chem. 1982;257(2):992-9. PMID:6274874 Klahr S, Morrissey J, Hruska K. Effect of parathyroid hormone on phospholipid metabolism. Adv Exp Med Biol. 1982;151:561-75. PMID:6758524 Martin KJ, Hruska K, Tamayo J, Arbelaez M, Slatopolsky E. Hepatic metabolism of parathyroid hormone. Miner Electrolyte Metab. 1982;8(3-4):173-8. PMID:7167132 Martin K, Hruska K, Slatopolsky E. Interactions between liver and parathyroid hormone. Adv Exp Med Biol. 1982;151:597-605. PMID:7180665 Hruska KA, Klahr S, Hammerman MR. Decreased luminal membrane transport of phosphate in chronic renal failure. Am J Physiol. 1982;242(1):F17-22. PMID:7058889 Hruska KA, Hammerman MR. Parathyroid hormone inhibition of phosphate transport in renal brush border vesicles from phosphate-depleted dogs. Biochim Biophys Acta. 1981;645(2):351-6. PMID:7272293 Rosenbaum RW, Hruska KA, Korkor A, Anderson C, Slatopolsky E. Decreased phosphate reabsorption after renal transplantation: Evidence for a mechanism independent of calcium and parathyroid hormone. Kidney Int. 1981;19(4):568-78. PMID:6264200 Hruska KA, Korkor A, Martin K, Slatopolsky E. Peripheral metabolism of intact parathyroid hormone. Role of liver and kidney and the effect of chronic renal failure. J Clin Invest. 1981;67(3):885-92. PMCID:PMC370640 PMID:7204561 Slatopolsky E, Martin K, Morrissey J, Hruska, K. Current concepts of the metabolism and radioimmunoassay of parathyroid hormone. Semin Nephrol. 1981;1:319-334.
Hammerman MR, Karl IE, Hruska KA. Regulation of canine renal vesicle Pi transport by growth hormone and parathyroid hormone. Biochim Biophys Acta. 1980;603(2):322-35. PMID:7459358 Sicard GA, Anderson CB, Hruska KA, Martin KJ, Etheredge EE. Parathormone levels after subtotal and total (autotransplantation) parathyroidectomy for secondary hyperparathyroidism. J Surg Res. 1980;29(6):541-5. PMID:7431907 Galim EB, Hruska K, Bier DM, Matthews DE, Haymond MW. Branched-chain amino acid nitrogen transfer to alamine in vivo in dogs. Direct isotopic determination with [15N]leucine. J Clin Invest. 1980;66(6):1295-304. doi:10.1172/JCI109981 PMCID:PMC371614 PMID:7440716 Teitelbaum SL, Bergfeld MA, Freitag J, Hruska KA, Slatopolsky E. Do parathyroid hormone and 1,25-dithydroxyvitamin D modulate bone formation in uremia? J Clin Endocrinol Metab. 1980;51(2):247-51. doi:10.1210/jcem-51-2-247 PMID:6893204 Martin KJ, Hruska K, Freitag J, Bellorin-Font E, Klahr S, Slatopolsky E. The clinical utility of radioimmunoassays for parathyroid hormone. Min Electrol Metab. 1980;3:283.
Martin KJ, Hruska KA, Freitag JJ, Klahr S, Slatopolsky E. The peripheral metabolism of parathyroid hormone. N Engl J Med. 1979;301(20):1092-8. doi:10.1056/NEJM197911153012005 PMID:386126 Hruska KA, Blondin J, Bass R, Santiago J, Thomas L, Altsheler P, Martin K, Klahr S. Effect of intact parathyroid hormone on hepatic glucose release in the dog. J Clin Invest. 1979;64(4):1016-23. doi:10.1172/JCI109538 PMCID:PMC372211 PMID:479365 Rosenbaum RW, Hruska KA, Anderson C, Robson AM, Slatopolsky E, Klahr S. Inulin: an inadequate marker of glomerular filtration rate in kidney donors and transplant recipients? Kidney Int. 1979;16(2):179-86. PMID:390219 Molitoris BA, Hruska KA, Fishman N, Daughaday WH. Effects of glucose and parathyroid hormone on the renal handling of myoinositol by isolated perfused dog kidneys. J Clin Invest. 1979;63(6):1110-8. doi:10.1172/JCI109403 PMCID:PMC372057 PMID:221533 Peterson LJ, Hruska KA. The benefits of evaluation of the patient with recurrent or multiple calcium stones. J Urol. 1979;121(6):766-8. PMID:458948 Martin KJ, Freitag JJ, Conrades MB, Hruska KA, Klahr S, Slatopolsky E. Selective uptake of the synthetic amino terminal fragment of bovine parathyroid hormone by isolated perfused bone. J Clin Invest. 1978;62(2):256-61. doi:10.1172/JCI109124 PMCID:PMC371761 PMID:209059 Hruska, K.A., Teitelbaum, S.L., Kopelman, R., Richardson, C.A., Miller, P., Debman, J., Martin, K., Slatopolsky, E. The predictability of the histologic al features of uremic bone disease by non-invasive techniques. Metab Bone Dis & Rel Res. 1978;1:39-44.
Slatopolsky E, Rutherford WE, Hruska K, Martin K, Klahr S. How important is phosphate in the pathogenesis of renal osteodystrophy? Arch Intern Med. 1978;138 Spec No:848-52. PMID:646572 Slatopolsky E, Gray R, Adams ND, Lewis J, Hruska K, Martin K, Klahr S, DeLuca HF, Lehmann J. Low levels of 1,25(OH)2D3 are not responsible for the development of secondary hyperparathyroidism in early renal failure. Kid Int. 1978;14:S733.
Anderson CB, Haid SD, Hruska KA, Etheredge EA. Significance of microbial contamination of stored cadaver kidneys. Arch Surg. 1978;113(3):269-71. PMID:25059 Freitag J, Martin KJ, Hruska KA, Anderson C, Conrades M, Ladenson J, Klahr S, Slatopolsky E. Impaired parathyroid hormone metabolism in patients with chronic renal failure. N Engl J Med. 1978;298(1):29-32. doi:10.1056/NEJM197801052980107 PMID:337145 Martin KJ, Freitag JJ, Conrades MB, Hruska K, Klahr S, Slatopolsky E. The uptake of parathyroid hormone by isolated perfused bone: possible significance of peripheral hormone metabolism. Trans Assoc Am Physicians. 1978;91:358-67. PMID:224552 Anderson CB, Haid SD, Hruska KA, Etheredge EE. Renal injury by companion kidney during hypothermic pulsatile perfusion. Surgery. 1978;83(1):72-7. PMID:619474 Teitelbaum SL, Hruska KA, Shieber W, Debnam JW, Nichols SH. Tetracycline fluorescence in uremic and primary hyperparathyroid bone. Kidney Int. 1977;12(5):366-72. PMID:604625 Martin KJ, Hruska KA, Lewis J, Anderson C, Slatopolsky E. The renal handling of parathyroid hormone. Role of peritubular uptake and glomerular filtration. J Clin Invest. 1977;60(4):808-14. doi:10.1172/JCI108834 PMCID:PMC372428 PMID:893678 Hruska KA, Martin K, Mennes P, Greenwalt A, Anderson C, Klahr S, Slatopolsky E. Degradation of parathyroid hormone and fragment production by the isolated perfused dog kidney. The effect of glomerular filtration rate and perfusate CA++ concentrations. J Clin Invest. 1977;60(3):501-10. doi:10.1172/JCI108802 PMCID:PMC372395 PMID:893661 Anderson CB, Haid SD, Hruska KA, Etheredge EE. Adverse effect of ischemic companion kidney during ex vivo renal perfusion. Transplant Proc. 1977;9(3):1625-7. PMID:331601 Rutherford WE, Bordier P, Marie P, Hruska K, Harter H, Greenwalt A, Blondin J, Haddad J, Bricker N, Slatopolsky E. Phosphate control and 25-hydroxycholecalciferol administration in preventing experimental renal osteodystrophy in the dog. J Clin Invest. 1977;60(2):332-41. doi:10.1172/JCI108781 PMCID:PMC372373 PMID:874095 Martin K, Hruska K, Greenwalt A, Klahr S, Slatopolsky E. Selective uptake of intact parathyroid hormone by the liver: differences between hepatic and renal uptake. J Clin Invest. 1976;58(4):781-8. doi:10.1172/JCI108529 PMCID:PMC333239 PMID:965485 Rutherford WE, Blondin J, Hruska K, Kopelman R, Klahr S, Slatopolsky E. Effect of 25-hydroxycholecalciferol on calcium absorption in chronic renal disease. Kidney Int. 1975;8(5):320-4. PMID:1195563 Hruska KA, Kopelman R, Rutherford WE, Klahr S, Slatopolsky E, Greenwalt A, Bascom T, Markham J. Metabolism in immunoreactive parathyroid hormone in the dog. The role of the kidney and the effects of chronic renal disease. J Clin Invest. 1975;56(1):39-48. doi:10.1172/JCI108077 PMCID:PMC436553 PMID:1141439 Rutherford WE, Hruska K, Blondin J, Holick M, DeLuca H, Klahr S, Slatopolsky E. The effect of 5,6-trans vitamin D3 on calcium absorption in chronic renal disease. J Clin Endocrinol Metab. 1975;40(1):13-18. doi:10.1210/jcem-40-1-13 PMID:1112871 Hruska K, Kopelman R, Rutherford WE, Greenwalt A, Klahr S, Slatopolsky E. Parathyroid hormone (PTH) metabolism in chronic renal disease (CRD). Proc Eur Dial Transplant Assoc. 1975;11:457-64. PMID:1197270 Rutherford E, Mercado A, Hruska KA, Harter H, Mason N, Sparks R, Klahr S, Slatopolsky E. An evaluation of a new and effective phosphate binding agent. Trans ASAIO. 1973;XIX.
Stein PD, Folkens AT, Hruska KA. Saccharomyces fungemia. Chest. 1970;58(2):173-5. PMID:5455300