Keith A. Hruska, M.D.  hruska_k@kids.wustl.edu

Professor of Pediatrics, Department of Medicine
Professor of Pediatrics, Nephrology
Professor of Pediatrics, Cell Biology & Physiology
Cell Biology & PhysiologyNephrologyDepartment of MedicinePathobiology

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Clinical Interests

My major clinical interest is the transformation of the clinical care of renal diseases and injuries into a preventive approach to the cardiovascular complications they produce which account for their mortality risk.

Education

  • BS, 1962 - 1965 Undergraduate, Creighton University, Omaha1965
  • MD, Creighton University School of Medicine1969

Training

  • Internship, Cornell University1969 - 1970
  • 1st yr Residency, Cornell University1970 - 1971
  • 2nd year Residency, Washington University, Barnes Hospital 1971 - 1972
  • Fellowship Nephrology, Washington University 1972 - 1974

Licensure and Board Certification

  • NE, 1969
  • MO, 1971
  • American Board of Internal Medicine 1972
  • IL, 1972
  • Subspecialty Boards, Nephrology 1975

Honors

  • Alpha Omega Alpha1969
  • Fellow, National Kidney Foundation1974 - 1974
  • Established Investigatorship, American Heart Association1979 - 1984
  • American Society for Clinical Investigation1981
  • Association of American Physicians (AAP)1985
  • Ira M Lange Chair in Nephrology1988 - 2001
  • Councilor, American Society of Bone and Mineral Metabolism1989 - 1992
  • Best Doctors in America2000 - 2015
  • International Pediatric Nephrology Association2004 - Pres
  • Who's Who in America2004 - 2015
  • Visiting Scientist - Spanish Society of Nephrology2005
  • Secretary/Treasurer - American Society of Bone and Mineral Research2006 - 2008
  • President Elect, American Society of Bone and Mineral Research2010 - 2011
  • President, American Society of Bone and Mineral Research2011 - 2012
  • Past-President, American Society of Bone and Mineral Research2012 - 2013
  • Alumni Achievement Award, Washington University2014
  • Shirley Hohl Service Award, American Bone and Mineral Research Society2014

Recent Publications view all (258)


Publication Co-Authors

  1. The activin receptor is stimulated in the skeleton, vasculature, heart and kidney during chronic kidney disease. Kidney International. 2017. 
  2. Crosstalk between kidney and bone - Bench to bedside. Bone. 2017;100:1-3. PMID:28412470 
  3. The chronic kidney disease - Mineral bone disorder (CKD-MBD): Advances in pathophysiology. Bone. 2017;100:80-86. PMCID:PMC5502716  PMID:28119179 
  4. Ligand trap of the activin receptor type IIA inhibits osteoclast stimulation of bone remodeling in diabetic mice with chronic kidney disease. Kidney Int. 2017;91(1):86-95. PMCID:PMC5530394  PMID:27666759 
  5. Bone Mineral Density and Progression of Subclinical Atherosclerosis in African-Americans With Type 2 Diabetes. J Clin Endocrinol Metab. 2016;101(11):4135-4141. PMCID:PMC5095232  PMID:27552541 
  6. Ligand trap for the activin type IIA receptor protects against vascular disease and renal fibrosis in mice with chronic kidney disease. Kidney Int. 2016;89(6):1231-43. PMCID:PMC4868771  PMID:27165838 
  7. Androgens Enhance Male Urinary Tract Infection Severity in a New Model. J Am Soc Nephrol. 2016;27(6):1625-34. PMCID:PMC4884108  PMID:26449605 
  8. Fibroblast growth factor-23 and chronic allograft injury in pediatric renal transplant recipients: a Midwest Pediatric Nephrology Consortium study. Pediatr Transplant. 2016;20(3):378-87. PMCID:PMC4818682  PMID:26880121 
  9. The Kidney-Vascular-Bone Axis in the Chronic Kidney Disease-Mineral Bone Disorder. Transplantation. 2016;100(3):497-505. PMCID:PMC4764429  PMID:26356179 
  10. SIRT6 deficiency culminates in low-turnover osteopenia. Bone. 2015;81:168-77. PMCID:PMC4640951  PMID:26189760 
  11. Pathophysiology of the chronic kidney disease-mineral bone disorder. Curr Opin Nephrol Hypertens. 2015;24(4):303-9. doi:10.1097/MNH.0000000000000132  PMCID:PMC4699443  PMID:26050115 
  12. Clinical phenotype of APOL1 nephropathy in young relatives of patients with end-stage renal disease. Pediatr Nephrol. 2015;30(6):983-9. doi:10.1007/s00467-014-3031-0  PMCID:PMC4406792  PMID:25530085 
  13. Plasma FGF23 and Calcified Atherosclerotic Plaque in African Americans with Type 2 Diabetes Mellitus. Am J Nephrol. 2015;42(6):391-401. doi:10.1159/000443241  PMCID:PMC4732898  PMID:26693712 
  14. Expression of DGCR8-dependent microRNAs is indispensable for osteoclastic development and bone-resorbing activity. J Cell Biochem. 2014;115(6):1043-7. doi:10.1002/jcb.24759  PMCID:PMCID: PMC4079251  PMID:24420069 
  15. CKD-induced wingless/integration1 inhibitors and phosphorus cause the CKD-mineral and bone disorder. J Am Soc Nephrol. 2014. doi:10.1681/ASN.2013080818  PMCID:PMCID: PMC4116062 [Available on 2015-08-01]  PMID:24578135 
  16. Sclerostin is positively associated with bone mineral density in men and women and negatively associated with carotid calcified atherosclerotic plaque in men from the African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2014;99(1):315-21. doi:10.1210/jc.2013-3168  PMCID:PMC3879670  PMID:24178795 
  17. Left ventricular mass progression despite stable blood pressure and kidney function in stage 3 chronic kidney disease. Am J Nephrol. 2014;39(5):392-9. doi:10.1159/000362251  PMCID:PMC4066883  PMID:24818573 
  18. HDAC dependent transcriptional repression of Bmp-7 potentiates TGF-β mediated renal fibrosis in obstructive uropathy. J Urol. 2014;191(1):242-52. doi:10.1016/j.juro.2013.06.110  PMCID:PMC4084877  PMID:23820056 
  19. Early chronic kidney disease-mineral bone disorder stimulates vascular calcification. Kidney Int. 2014;85(1):142-50. doi:10.1038/ki.2013.271  PMCID:PMC3836911  PMID:23884339 
  20. Phosphate homeostasis in CKD: report of a scientific symposium sponsored by the National Kidney Foundation. Am J Kidney Dis. 2013;62(3):457-73. doi:10.1053/j.ajkd.2013.03.042  PMID:23763855 
  21. Buyer beware! doctor be aware!: Questions. Pediatr Nephrol. 2013;28(9):1785; answer 1787-90. doi:10.1007/s00467-012-2338-y  PMID:23111895 
  22. Down-regulation of miR-21 biogenesis by estrogen action contributes to osteoclastic apoptosis. J Cell Biochem. 2013;114(6):1217-22. doi:10.1002/jcb.24471  PMCID:PMCID: PMC4154486  PMID:23238785 
  23. Relationships between serum adiponectin and bone density, adiposity and calcified atherosclerotic plaque in the African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2013;98(5):1916-22. doi:10.1210/jc.2012-4126  PMCID:PMC3644610  PMID:23543659 
  24. Admixture mapping of coronary artery calcified plaque in African Americans with type 2 diabetes mellitus. Circ Cardiovasc Genet. 2013;6(1):97-105. doi:10.1161/CIRCGENETICS.112.964114  PMCID:PMC3578054  PMID:23233742 
  25. Effects of phosphate binder therapy on vascular stiffness in early-stage chronic kidney disease. Am J Nephrol. 2013;38(2):158-67. doi:10.1159/000353569  PMID:23941761 
  26. Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes. J Clin Endocrinol Metab. 2013;98(1):E60-5. doi:10.1210/jc.2012-3038  PMCID:PMC3537092  PMID:23125289 
  27. Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study. BMC Nephrol. 2012;13:148. doi:10.1186/1471-2369-13-148  PMCID:PMC3534523  PMID:23151275 
  28. Traditional and targeted exome sequencing reveals common, rare and novel functional deleterious variants in RET-signaling complex in a cohort of living US patients with urinary tract malformations. Hum Genet. 2012;131(11):1725-38. doi:10.1007/s00439-012-1181-3  PMCID:PMC3551468  PMID:22729463 
  29. Endogenous BMP-7 is a critical molecular determinant of the reversibility of obstruction-induced renal injuries. Am J Physiol Renal Physiol. 2011;301(6):F1293-302. doi:10.1152/ajprenal.00071.2011  PMCID:PMC3774217  PMID:21880836 
  30. RGS4, a GTPase activator, improves renal function in ischemia-reperfusion injury. Kidney Int. 2011;80(3):263-71. doi:10.1038/ki.2011.63  PMCID:PMC3221244  PMID:21412219 
  31. Relationships between calcified atherosclerotic plaque and bone mineral density in African Americans with type 2 diabetes. J Bone Miner Res. 2011;26(7):1554-60. doi:10.1002/jbmr.389  PMID:21437982 
  32. The BMP-7-Smad1/5/8 pathway promotes kidney repair after obstruction induced renal injury. J Urol. 2011;185(6 Suppl):2523-30. doi:10.1016/j.juro.2011.01.034  PMCID:PMC3418146  PMID:21527199 
  33. A microRNA expression signature of osteoclastogenesis. Blood. 2011;117(13):3648-57. doi:10.1182/blood-2010-10-311415  PMCID:PMC3072882  PMID:21273303 
  34. The roles of the skeleton and phosphorus in the CKD mineral bone disorder. Adv Chronic Kidney Dis. 2011;18(2):98-104. doi:10.1053/j.ackd.2011.01.001  PMCID:PMC3103992  PMID:21406294 
  35. The new kidney disease: improving global outcomes (KDIGO) guidelines - expert clinical focus on bone and vascular calcification. Clin Nephrol. 2010;74(6):423-32. PMCID:PMC3770279  PMID:21084045 
  36. Cardiovascular risk in chronic kidney disease (CKD): the CKD-mineral bone disorder (CKD-MBD). Pediatr Nephrol. 2010;25(4):769-78. doi:10.1007/s00467-009-1337-0  PMCID:PMC3719392  PMID:19898875 
  37. Voltage dependent calcium channel expression in isolated osteoclasts Boll Soc Ital Biol Sper. 2009;65(12):1115-1118. 
  38. Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study. J Bone Miner Res. 2009;24(10):1719-27. doi:10.1359/jbmr.090501  PMCID:PMC2743282  PMID:19453255 
  39. CKD accelerates development of neointimal hyperplasia in arteriovenous fistulas. J Am Soc Nephrol. 2009;20(6):1236-45. doi:10.1681/ASN.2007121312  PMCID:PMC2689906  PMID:19423694 
  40. Vascular smooth muscle cells in the pathogenesis of vascular calcification. Circ Res. 2009;104(6):710-1. doi:10.1161/CIRCRESAHA.109.195487  PMID:19325156 
  41. The pathogenesis of vascular calcification in the chronic kidney disease mineral bone disorder: the links between bone and the vasculature. Semin Nephrol. 2009;29(2):156-65. doi:10.1016/j.semnephrol.2009.01.008  PMCID:PMC2758096  PMID:19371806 
  42. Impaired micro-RNA pathways diminish osteoclast differentiation and function. J Biol Chem. 2009;284(7):4667-78. doi:10.1074/jbc.M805777200  PMCID:PMC2640963  PMID:19059913 
  43. Vitamin D receptor activators can protect against vascular calcification. J Am Soc Nephrol. 2008;19(8):1509-19. doi:10.1681/ASN.2007080902  PMCID:PMC2488263  PMID:18448587 
  44. Hyperphosphatemia of chronic kidney disease. Kidney Int. 2008;74(2):148-57. doi:10.1038/ki.2008.130  PMCID:PMC2735026  PMID:18449174 
  45. The mechanism of phosphorus as a cardiovascular risk factor in CKD. J Am Soc Nephrol. 2008;19(6):1092-105. doi:10.1681/ASN.2007070760  PMCID:PMC2396927  PMID:18417722 
  46. Osteoporosis and cardiovascular disease: lessons from chronic kidney disease. Clin Cases Miner Bone Metab. 2008;5(1):35-9. PMCID:PMC2781186  PMID:22460843 
  47. Bone morphogenetic protein-7 delays podocyte injury due to high glucose. Nephrol Dial Transplant. 2007;22(12):3442-50. doi:10.1093/ndt/gfm503  PMID:17686813 
  48. MicroRNA-223 is a key factor in osteoclast differentiation. J Cell Biochem. 2007;101(4):996-9. doi:10.1002/jcb.21335  PMID:17471500 
  49. Renal osteodystrophy, phosphate homeostasis, and vascular calcification. Semin Dial. 2007;20(4):309-15. PMID:17635820 
  50. Reversal of the adynamic bone disorder and decreased vascular calcification in chronic kidney disease by sevelamer carbonate therapy. J Am Soc Nephrol. 2007;18(1):122-30. doi:10.1681/ASN.2006050490  PMID:17182886 
  51. Function and effect of bone morphogenetic protein-7 in kidney bone and the bone-vascular links in chronic kidney disease. Eur J Clin Invest. 2006;36 Suppl 2:43-50. doi:10.1111/j.1365-2362.2006.01663.x  PMID:16884397 
  52. New insights into mineral and skeletal regulation by active forms of vitamin D. Kidney Int. 2006;69(2):218-23. doi:10.1038/sj.ki.5000091  PMID:16408109 
  53. New discoveries in the pathogenesis of renal osteodystrophy. J Bone Miner Metab. 2006;24(2):169-71. doi:10.1007/s00774-005-0666-8  PMID:16502127 
  54. Connections between vascular calcification and progression of chronic kidney disease: therapeutic alternatives. Kidney Int Suppl. 2005;(99):S142-51. doi:10.1111/j.1523-1755.2005.09926.x  PMID:16336568 
  55. Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol. 2005;16(8):2373-84. doi:10.1681/ASN.2004110949  PMID:15944336 
  56. Bone morphogenetic proteins in vascular calcification. Circ Res. 2005;97(2):105-14. doi:10.1161/01.RES.00000175571.53833.6c  PMID:16037577 
  57. Hospital-independent organ recovery from deceased donors: a two-year experience. Am J Transplant. 2005;5(5):1105-10. doi:10.1111/j.1600-6143.2005.00804.x  PMID:15816893 
  58. Low turnover osteodystrophy and vascular calcification are amenable to skeletal anabolism in an animal model of chronic kidney disease and the metabolic syndrome. J Am Soc Nephrol. 2005;16(4):917-28. doi:10.1681/ASN.2004100835  PMID:15743994 
  59. Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors. J Biol Chem. 2005;280(5):3583-9. doi:10.1074/jbc.M410480200  PMID:15545269 
  60. In vivo transplantation of neonatal ovine neocartilage allografts: determining the effectiveness of tissue transglutaminase. J Knee Surg. 2005;18(1):31-42. PMID:15742595 
  61. Bone morphogenetic protein 7: a novel treatment for chronic renal and bone disease. Curr Opin Nephrol Hypertens. 2004;13(4):417-22. PMID:15199292 
  62. Polyphosphoinositides-dependent regulation of the osteoclast actin cytoskeleton and bone resorption. BMC Cell Biol. 2004;5:19. doi:10.1186/1471-2121-5-19  PMCID:PMC441372  PMID:15142256 
  63. Vascular calcification in chronic kidney disease. Am J Kidney Dis. 2004;43(3):572-9. PMID:14981617 
  64. Differential growth factor control of bone formation through osteoprogenitor differentiation. Bone. 2004;34(3):402-11. doi:10.1016/j.bone.2003.11.014  PMID:15003788 
  65. Successful treatment of an adynamic bone disorder with bone morphogenetic protein-7 in a renal ablation model. J Am Soc Nephrol. 2004;15(2):359-69. PMID:14747382 
  66. Adenovirus mediated BMP-13 gene transfer induces chondrogenic differentiation of murine mesenchymal progenitor cells. J Bone Miner Res. 2004;19(1):111-22. doi:10.1359/jbmr.2004.19.1.111  PMID:14753743 
  67. Kidney-bone, bone-kidney, and cell-cell communications in renal osteodystrophy. Semin Nephrol. 2004;24(1):25-38. PMID:14730507 
  68. Impairment of the collagenase-3 endocytotic receptor system in cells from patients with osteoarthritis. Osteoarthritis Cartilage. 2003;11(12):854-63. PMID:14629961 
  69. Activin A stimulates IkappaB-alpha/NFkappaB and RANK expression for osteoclast differentiation, but not AKT survival pathway in osteoclast precursors. J Cell Biochem. 2003;90(1):59-67. doi:10.1002/jcb.10613  PMID:12938156 
  70. Rho-dependent Rho kinase activation increases CD44 surface expression and bone resorption in osteoclasts. J Biol Chem. 2003;278(31):29086-97. doi:10.1074/jbc.M211074200  PMID:12730217 
  71. Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy. Kidney Int. 2003;63(6):2037-49. doi:10.1046/j.1523-1755.2003.00035.x  PMID:12753291 
  72. The urinary response to an oral oxalate load in recurrent calcium stone formers. J Urol. 2003;169(6):2030-3. doi:10.1097/01.ju.0000062527.37579.49  PMID:12771711 
  73. BMP-7 is an efficacious treatment of vascular calcification in a murine model of atherosclerosis and chronic renal failure. J Am Soc Nephrol. 2003;14(6):1559-67. PMID:12761256 
  74. The pathogenesis of osteodystrophy after renal transplantation as detected by early alterations in bone remodeling. Kidney Int. 2003;63(5):1915-23. doi:10.1046/j.1523-1755.2003.00938.x  PMID:12675872 
  75. Inhibition of cell survival signal protein kinase B/Akt by curcumin in human prostate cancer cells. J Cell Biochem. 2003;89(1):1-5. doi:10.1002/jcb.10495  PMID:12682902 
  76. Post-transplant osteodystrophy in the era of the K/DOQI guidelines. Dialysis & Transplantation. 2003;32:651-658. 
  77. Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast. J Bone Miner Res. 2003;18(4):669-85. doi:10.1359/jbmr.2003.18.4.669  PMID:12674328 
  78. The integrin alpha(v)beta(3) and CD44 regulate the actions of osteopontin on osteoclast motility. Calcif Tissue Int. 2003;72(3):197-205. doi:10.1007/s00223-002-1025-6  PMID:12469249 
  79. PTEN regulates RANKL- and osteopontin-stimulated signal transduction during osteoclast differentiation and cell motility. J Biol Chem. 2003;278(7):5001-8. doi:10.1074/jbc.M209299200  PMID:12460992 
  80. Proprotein convertases regulate activity of prostate epithelial cell differentiation markers and are modulated in human prostate cancer cells. J Cell Biochem. 2003;88(2):394-9. doi:10.1002/jcb.10327  PMID:12520542 
  81. Osteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expression. Mol Biol Cell. 2003;14(1):173-89. doi:10.1091/mbc.E02-06-0354  PMCID:PMC140236  PMID:12529435 
  82. Cadaveric-donor organ recovery at a hospital-independent facility. Transplantation. 2002;74(7):978-82. PMID:12394841 
  83. Treatment of chronic tubulointerstitial disease: a new concept. Kidney Int. 2002;61(5):1911-22. doi:10.1046/j.1523-1755.2002.00331.x  PMID:11967050 
  84. New approaches to delay the progression of chronic renal failure. Kidney Int Suppl. 2002;(80):23-6. doi:10.1046/j.1523-1755.61.s80.16.x  PMID:11982808 
  85. Treatment of a murine model of high-turnover renal osteodystrophy by exogenous BMP-7. Kidney Int. 2002;61(4):1322-31. doi:10.1046/j.1523-1755.2002.00258.x  PMID:11918739 
  86. Bone morphogenetic protein-7 improves renal fibrosis and accelerates the return of renal function. J Am Soc Nephrol. 2002;13 Suppl 1:S14-21. PMID:11792757 
  87. Bone morphogenetic protein-7: an anti-fibrotic morphogenetic protein with therapeutic importance in renal disease. Curr Opin Nephrol Hypertens. 2002;11(1):31-6. PMID:11753084 
  88. Phosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolin. J Biol Chem. 2001;276(50):47434-44. doi:10.1074/jbc.M107494200  PMID:11577104 
  89. Identification of the type II Na(+)-Pi cotransporter (Npt2) in the osteoclast and the skeletal phenotype of Npt2-/- mice. Bone. 2001;29(5):467-76. PMID:11704500 
  90. In vitro generation of scaffold independent neocartilage. Clin Orthop Relat Res. 2001;(391 Suppl):S280-94. PMID:11603712 
  91. Rho family GTPases regulate VEGF-stimulated endothelial cell motility. Exp Cell Res. 2001;269(1):73-87. doi:10.1006/excr.2001.5295  PMID:11525641 
  92. Pathophysiological mechanisms of vascular calcification in end-stage renal disease. Kidney Int. 2001;60(2):472-9. doi:10.1046/j.1523-1755.2001.060002472.x  PMID:11473629 
  93. Protein transduction: delivery of Tat-GTPase fusion proteins into mammalian cells Methods Enzymol. 2001;332:36-49. 
  94. Receptor-operated osteoclast calcium sensing. Endocrinology. 2001;142(5):1968-74. doi:10.1210/endo.142.5.8125  PMID:11316762 
  95. Parathyroid hormone-induced bone resorption does not occur in the absence of osteopontin. J Biol Chem. 2001;276(16):13065-71. doi:10.1074/jbc.M010938200  PMID:11278791 
  96. The cell survival signal Akt is differentially activated by PDGF-BB, EGF, and FGF-2 in osteoblastic cells. J Cell Biochem. 2001;81(2):304-11. PMID:11241670 
  97. Rac regulates vascular endothelial growth factor stimulated motility. Cell Commun Adhes. 2001;8(1):1-13. PMID:11775025 
  98. Mechanically strained cells of the osteoblast lineage organize their extracellular matrix through unique sites of alphavbeta3-integrin expression. J Bone Miner Res. 2000;15(9):1731-45. doi:10.1359/jbmr.2000.15.9.1731  PMID:10976993 
  99. Protein transduction: unrestricted delivery into all cells? Trends Cell Biol. 2000;10(7):290-5. PMID:10856932 
  100. Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction. Am J Physiol Renal Physiol. 2000;279(1):F130-43. PMID:10894795 
  101. Dawning of a New Era at CTI Calcif Tissue Int. 2000;67(1):1. PMID:10908404 
  102. Pathophysiology of renal osteodystrophy Pediatr Nephrol. 2000;14:636-640. 
  103. Rapid quantitative bioassay of osteoinduction. J Orthop Res. 2000;18(3):503-11. doi:10.1002/jor.1100180326  PMID:10937641 
  104. Rac is essential in the transformation of endothelial cells by polyoma middle T. Cell Adhes Commun. 2000;7(5):409-22. PMID:10830619 
  105. Rho-A is critical for osteoclast podosome organization, motility, and bone resorption. J Biol Chem. 2000;275(16):11993-2002. PMID:10766830 
  106. Regulation of alphaVbeta3 and alphaVbeta5 integrins by dexamethasone in normal human osteoblastic cells. J Cell Biochem. 2000;77(2):265-76. PMID:10723092 
  107. Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength. J Cell Biol. 2000;148(4):665-78. PMCID:PMC2169374  PMID:10684249 
  108. New insights related to aging and renal osteodystrophy. Geriatr Nephrol Urol. 1999;9(1):49-56. PMID:10435227 
  109. Volume regulatory decrease in UMR-106.01 cells is mediated by specific alpha1 subunits of L-type calcium channels. Cell Biochem Biophys. 1999;31(1):65-79. doi:10.1007/BF02738155  PMID:10505668 
  110. Osteopontin. Drug News Perspect. 1998;11(6):350-5. PMID:15616623 
  111. Ma-huang strikes again: ephedrine nephrolithiasis. Am J Kidney Dis. 1998;32(1):153-9. PMID:9669437 
  112. Correlation of plasma concentrations of cystatin C and creatinine to inulin clearance in a pediatric population. Clin Chem. 1998;44(6 Pt 1):1334-8. PMID:9625061 
  113. c-Src is required for stimulation of gelsolin-associated phosphatidylinositol 3-kinase. J Biol Chem. 1998;273(19):11908-16. PMID:9565618 
  114. Colony stimulating factor-1-induced osteoclast spreading depends on substrate and requires the vitronectin receptor and the c-src proto-oncogene. J Bone Miner Res. 1998;13(1):50-8. doi:10.1359/jbmr.1998.13.1.50  PMID:9443790 
  115. The mitogenic effect of parathyroid hormone is associated with E2F-dependent activation of cyclin-dependent kinase 1 (cdc2) in osteoblast precursors. J Bone Miner Res. 1997;12(10):1596-605. doi:10.1359/jbmr.1997.12.10.1596  PMID:9333120 
  116. Skeletal casein kinase activity defect in the HYP mouse. Calcif Tissue Int. 1997;61(3):256-9. PMID:9262518 
  117. Regulation of sodium-dependent phosphate transport in osteoclasts. J Clin Invest. 1997;100(3):538-49. doi:10.1172/JCI119563  PMCID:PMC508220  PMID:9239400 
  118. Genomic organization of a human cystine transporter gene (SLC3A1) and identification of novel mutations causing cystinuria. Kidney Int. 1997;51(6):1893-9. PMID:9186880 
  119. Expression of p27Kip1 in osteoblast-like cells during differentiation with parathyroid hormone. Endocrinology. 1997;138(5):1995-2004. doi:10.1210/endo.138.5.5146  PMID:9112398 
  120. Renal osteodystrophy. Baillieres Clin Endocrinol Metab. 1997;11(1):165-94. PMID:9222491 
  121. Metanephric osteopontin regulates nephrogenesis in vitro. Am J Physiol. 1997;272(4 Pt 2):F469-76. PMID:9140047 
  122. Reconstitution of stretch-activated cation channels by expression of the alpha-subunit of the epithelial sodium channel cloned from osteoblasts. Proc Natl Acad Sci U S A. 1997;94(3):1013-8. PMCID:PMC19631  PMID:9023374 
  123. Association of 1 alpha,25-dihydroxyvitamin D3-occupied vitamin D receptors with cellular membrane acceptance sites. Endocrinology. 1996;137(9):3649-58. doi:10.1210/endo.137.9.8756529  PMID:8756529 
  124. Osteopontin activation of c-src in human melanoma cells requires the cytoplasmic domain of the integrin alpha v-subunit. Endocrinology. 1996;137(6):2432-40. doi:10.1210/endo.137.6.8641196  PMID:8641196 
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