Keith A. Hruska, M.D.

Professor of Pediatrics, Department of Medicine
Professor of Pediatrics, Nephrology
Professor of Pediatrics, Cell Biology & Physiology
Cell Biology & PhysiologyNephrologyDepartment of MedicinePathobiology


Clinical Interests

My major clinical interest is the transformation of the clinical care of renal diseases and injuries into a preventive approach to the cardiovascular complications they produce which account for their mortality risk.


  • B.S., 1962 - 1965 Undergraduate, Creighton University, Omaha1965
  • M.D., Creighton University School of Medicine1969


  • Internship, Cornell University1969 - 1970
  • 1st yr Residency, Cornell University1970 - 1971
  • 2nd year Residency, Washington University, Barnes Hospital 1971 - 1972
  • Fellowship Nephrology, Washington University 1972 - 1974

Licensure and Board Certification

  • NE, 1969
  • MO, 1971
  • American Board of Internal Medicine1972
  • IL, 1972
  • Subspecialty Boards, Nephrology1975


  • Alpha Omega Alpha1969
  • Fellow, National Kidney Foundation1974 - 1974
  • Established Investigatorship, American Heart Association1979 - 1984
  • American Society for Clinical Investigation1981
  • Association of American Physicians (AAP)1985
  • Ira M Lange Chair in Nephrology1988 - 2001
  • Councilor, American Society of Bone and Mineral Metabolism1989 - 1992
  • Best Doctors in America2000 - 2015
  • International Pediatric Nephrology Association2004 - Pres
  • Who's Who in America2004 - 2015
  • Visiting Scientist - Spanish Society of Nephrology2005
  • Secretary/Treasurer - American Society of Bone and Mineral Research2006 - 2008
  • President Elect, American Society of Bone and Mineral Research2010 - 2011
  • President, American Society of Bone and Mineral Research2011 - 2012
  • Past-President, American Society of Bone and Mineral Research2012 - 2013
  • Alumni Achievement Award, Washington University2014
  • Shirley Hohl Service Award, American Bone and Mineral Research Society2014

Recent Publications view all (255)

Publication Co-Authors

  1. Sugatani, Toshifumi Agapova, Olga A. Fang, Yifu Berman, Alycia G. Wallace, Joseph M. Malluche, Hartmut H. Faugere, Marie-Claude Smith, William Sung, Victoria Hruska, Keith A.. Ligand trap of the activin receptor type IIA inhibits osteoclast stimulation of bone remodeling in diabetic mice with chronic kidney disease Kid Int. 2016;90.  
  2. Lynne E. WagenknechtDrPH, Jasmin DiversPhD, Thomas C. RegisterPhD, Gregory B. RussellMS, Donald W. BowdenPhD, Jianzhao XuBS, Carl D. LangefeldPhD, Leon LenchikMD, Keith A. HruskaMD, J. Jeffrey CarrMD, and Barry I. FreedmanMD. Bone mineral density and progression of subclinical atherosclerosis in African Americans with type 2 diabetes ... JCEM. 2016;101. doi:DOI:10.1210/jc.2016-1934  
  3. Agapova OA, Fang Y, Sugatani T, Seifert ME, Hruska KA. Ligand trap for the activin type IIA receptor protects against vascular disease and renal fibrosis in mice with chronic kidney disease. Kidney Int. 2016;89(6):1231-43. PMCID:PMC4868771  PMID:27165838  
  4. Olson PD, Hruska KA, Hunstad DA. Androgens Enhance Male Urinary Tract Infection Severity in a New Model. J Am Soc Nephrol. 2016;27(6):1625-34. PMCID:PMC4884108  PMID:26449605  
  5. Seifert ME, Ashoor IF, Chiang ML, Chishti AS, Dietzen DJ, Gipson DS, Janjua HS, Selewski DT, Hruska KA. Fibroblast growth factor-23 and chronic allograft injury in pediatric renal transplant recipients: a Midwest Pediatric Nephrology Consortium study. Pediatr Transplant. 2016;20(3):378-87. PMCID:PMC4818682  PMID:26880121  
  6. Seifert ME, Hruska KA. The Kidney-Vascular-Bone Axis in the Chronic Kidney Disease-Mineral Bone Disorder. Transplantation. 2016;100(3):497-505. PMCID:PMC4764429  PMID:26356179  
  7. Sugatani T, Agapova O, Malluche HH, Hruska KA. SIRT6 deficiency culminates in low-turnover osteopenia. Bone. 2015;81:168-77. PMCID:PMC4640951  PMID:26189760  
  8. Hruska KA, Seifert M, Sugatani T. Pathophysiology of the chronic kidney disease-mineral bone disorder. Curr Opin Nephrol Hypertens. 2015;24(4):303-9. doi:10.1097/MNH.0000000000000132  PMCID:PMC4699443  PMID:26050115  
  9. Anyaegbu EI, Shaw AS, Hruska KA, Jain S. Clinical phenotype of APOL1 nephropathy in young relatives of patients with end-stage renal disease. Pediatr Nephrol. 2015;30(6):983-9. doi:10.1007/s00467-014-3031-0  PMCID:PMC4406792  PMID:25530085  
  10. Freedman BI, Divers J, Russell GB, Palmer ND, Bowden DW, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Langefeld CD, Hruska KA, Register TC. Plasma FGF23 and Calcified Atherosclerotic Plaque in African Americans with Type 2 Diabetes Mellitus. Am J Nephrol. 2015;42(6):391-401. doi:10.1159/000443241  PMCID:PMC4732898  PMID:26693712  
  11. Sugatani T, Hildreth BE 3rd, Toribio RE, Malluche HH, Hruska KA. Expression of DGCR8-dependent microRNAs is indispensable for osteoclastic development and bone-resorbing activity. J Cell Biochem. 2014;115(6):1043-7. doi:10.1002/jcb.24759  PMCID:PMCID: PMC4079251  PMID:24420069  
  12. Fang Y, Ginsberg C, Seifert M, Agapova O, Sugatani T, Register TC, Freedman BI, Monier-Faugere MC, Malluche H, Hruska KA. CKD-induced wingless/integration1 inhibitors and phosphorus cause the CKD-mineral and bone disorder. J Am Soc Nephrol. 2014. doi:10.1681/ASN.2013080818  PMCID:PMCID: PMC4116062 [Available on 2015-08-01]  PMID:24578135  
  13. Fang Y, Ginsberg C, Sugatani T, Monier-Faugere MC, Malluche H, Hruska KA. Early chronic kidney disease-mineral bone disorder stimulates vascular calcification. Kidney Int. 2014;85(1):142-50. doi:10.1038/ki.2013.271  PMCID:PMC3836911  PMID:23884339  
  14. Manson SR, Song JB, Hruska KA, Austin PF. HDAC dependent transcriptional repression of Bmp-7 potentiates TGF-β mediated renal fibrosis in obstructive uropathy. J Urol. 2014;191(1):242-52. doi:10.1016/j.juro.2013.06.110  PMCID:PMC4084877  PMID:23820056  
  15. Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI. Sclerostin is positively associated with bone mineral density in men and women and negatively associated with carotid calcified atherosclerotic plaque in men from the African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2014;99(1):315-21. doi:10.1210/jc.2013-3168  PMCID:PMC3879670  PMID:24178795  
  16. Seifert ME, de Las Fuentes L, Ginsberg C, Rothstein M, Dietzen DJ, Cheng SC, Ross W, Windus D, Dávila-Román VG, Hruska KA. Left ventricular mass progression despite stable blood pressure and kidney function in stage 3 chronic kidney disease. Am J Nephrol. 2014;39(5):392-9. doi:10.1159/000362251  PMCID:PMC4066883  PMID:24818573  
  17. Block GA, Ix JH, Ketteler M, Martin KJ, Thadhani RI, Tonelli M, Wolf M, Jüppner H, Hruska K, Wheeler DC. Phosphate homeostasis in CKD: report of a scientific symposium sponsored by the National Kidney Foundation. Am J Kidney Dis. 2013;62(3):457-73. doi:10.1053/j.ajkd.2013.03.042  PMID:23763855  
  18. Anyaegbu E, Davis TK, Kniska K, Hruska K, Beck A. Buyer beware! doctor be aware!: Questions. Pediatr Nephrol. 2013;28(9):1785; answer 1787-90. doi:10.1007/s00467-012-2338-y  PMID:23111895  
  19. Sugatani T, Hruska KA. Down-regulation of miR-21 biogenesis by estrogen action contributes to osteoclastic apoptosis. J Cell Biochem. 2013;114(6):1217-22. doi:10.1002/jcb.24471  PMCID:PMCID: PMC4154486  PMID:23238785  
  20. Register TC, Divers J, Bowden DW, Carr JJ, Lenchik L, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Hruska KA, Langefeld CD, Freedman BI. Relationships between serum adiponectin and bone density, adiposity and calcified atherosclerotic plaque in the African American-Diabetes Heart Study. J Clin Endocrinol Metab. 2013;98(5):1916-22. doi:10.1210/jc.2012-4126  PMCID:PMC3644610  PMID:23543659  
  21. Divers J, Palmer ND, Lu L, Register TC, Carr JJ, Hicks PJ, Hightower RC, Smith SC, Xu J, Cox AJ, Hruska KA, Bowden DW, Lewis CE, Heiss G, Province MA, Borecki IB, Kerr KF, Chen YD, Palmas W, Rotter JI, Wassel CL, Bertoni AG, Herrington DM, Wagenknecht LE, Langefeld CD, Freedman BI. Admixture mapping of coronary artery calcified plaque in African Americans with type 2 diabetes mellitus. Circ Cardiovasc Genet. 2013;6(1):97-105. doi:10.1161/CIRCGENETICS.112.964114  PMCID:PMC3578054  PMID:23233742  
  22. Seifert ME, de las Fuentes L, Rothstein M, Dietzen DJ, Bierhals AJ, Cheng SC, Ross W, Windus D, Dávila-Román VG, Hruska KA. Effects of phosphate binder therapy on vascular stiffness in early-stage chronic kidney disease. Am J Nephrol. 2013;38(2):158-67. doi:10.1159/000353569  PMID:23941761  
  23. Register TC, Hruska KA, Divers J, Bowden DW, Palmer ND, Carr JJ, Wagenknecht LE, Hightower RC, Xu J, Smith SC, Dietzen DJ, Langefeld CD, Freedman BI. Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes. J Clin Endocrinol Metab. 2013;98(1):E60-5. doi:10.1210/jc.2012-3038  PMCID:PMC3537092  PMID:23125289  
  24. Murea M, Register TC, Divers J, Bowden DW, Carr JJ, Hightower CR, Xu J, Smith SC, Hruska KA, Langefeld CD, Freedman BI. Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study. BMC Nephrol. 2012;13:148. doi:10.1186/1471-2369-13-148  PMCID:PMC3534523  PMID:23151275  
  25. Chatterjee R, Ramos E, Hoffman M, VanWinkle J, Martin DR, Davis TK, Hoshi M, Hmiel SP, Beck A, Hruska K, Coplen D, Liapis H, Mitra R, Druley T, Austin P, Jain S. Traditional and targeted exome sequencing reveals common, rare and novel functional deleterious variants in RET-signaling complex in a cohort of living US patients with urinary tract malformations. Hum Genet. 2012;131(11):1725-38. doi:10.1007/s00439-012-1181-3  PMCID:PMC3551468  PMID:22729463  
  26. Manson SR, Niederhoff RA, Hruska KA, Austin PF. Endogenous BMP-7 is a critical molecular determinant of the reversibility of obstruction-induced renal injuries. Am J Physiol Renal Physiol. 2011;301(6):F1293-302. doi:10.1152/ajprenal.00071.2011  PMCID:PMC3774217  PMID:21880836  
  27. Siedlecki AM, Jin X, Thomas W, Hruska KA, Muslin AJ. RGS4, a GTPase activator, improves renal function in ischemia-reperfusion injury. Kidney Int. 2011;80(3):263-71. doi:10.1038/ki.2011.63  PMCID:PMC3221244  PMID:21412219  
  28. Divers J, Register TC, Langefeld CD, Wagenknecht LE, Bowden DW, Carr JJ, Hightower RC, Xu J, Hruska KA, Freedman BI. Relationships between calcified atherosclerotic plaque and bone mineral density in African Americans with type 2 diabetes. J Bone Miner Res. 2011;26(7):1554-60. doi:10.1002/jbmr.389  PMID:21437982  
  29. Manson SR, Niederhoff RA, Hruska KA, Austin PF. The BMP-7-Smad1/5/8 pathway promotes kidney repair after obstruction induced renal injury. J Urol. 2011;185(6 Suppl):2523-30. doi:10.1016/j.juro.2011.01.034  PMCID:PMC3418146  PMID:21527199  
  30. Sugatani T, Vacher J, Hruska KA. A microRNA expression signature of osteoclastogenesis. Blood. 2011;117(13):3648-57. doi:10.1182/blood-2010-10-311415  PMCID:PMC3072882  PMID:21273303  
  31. Hruska KA, Mathew S. The roles of the skeleton and phosphorus in the CKD mineral bone disorder. Adv Chronic Kidney Dis. 2011;18(2):98-104. doi:10.1053/j.ackd.2011.01.001  PMCID:PMC3103992  PMID:21406294  
  32. London G, Coyne D, Hruska K, Malluche HH, Martin KJ. The new kidney disease: improving global outcomes (KDIGO) guidelines - expert clinical focus on bone and vascular calcification. Clin Nephrol. 2010;74(6):423-32. PMCID:PMC3770279  PMID:21084045  
  33. Hruska KA, Choi ET, Memon I, Davis TK, Mathew S. Cardiovascular risk in chronic kidney disease (CKD): the CKD-mineral bone disorder (CKD-MBD). Pediatr Nephrol. 2010;25(4):769-78. doi:10.1007/s00467-009-1337-0  PMCID:PMC3719392  PMID:19898875  
  34. Teti A, Grano M, Colucci S, Argentino L, Barattolo R, Miyauchi A, Teitelbaum SL, Hruska KA, Zambonin-Zallone A. Voltage dependent calcium channel expression in isolated osteoclasts Boll Soc Ital Biol Sper. 2009;65(12):1115-1118. 
  35. Freedman BI, Bowden DW, Ziegler JT, Langefeld CD, Lehtinen AB, Rudock ME, Lenchik L, Hruska KA, Register TC, Carr JJ. Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study. J Bone Miner Res. 2009;24(10):1719-27. doi:10.1359/jbmr.090501  PMCID:PMC2743282  PMID:19453255  
  36. Kokubo T, Ishikawa N, Uchida H, Chasnoff SE, Xie X, Mathew S, Hruska KA, Choi ET. CKD accelerates development of neointimal hyperplasia in arteriovenous fistulas. J Am Soc Nephrol. 2009;20(6):1236-45. doi:10.1681/ASN.2007121312  PMCID:PMC2689906  PMID:19423694  
  37. Hruska KA. Vascular smooth muscle cells in the pathogenesis of vascular calcification. Circ Res. 2009;104(6):710-1. doi:10.1161/CIRCRESAHA.109.195487  PMID:19325156  
  38. Hruska KA, Mathew S, Lund RJ, Memon I, Saab G. The pathogenesis of vascular calcification in the chronic kidney disease mineral bone disorder: the links between bone and the vasculature. Semin Nephrol. 2009;29(2):156-65. doi:10.1016/j.semnephrol.2009.01.008  PMCID:PMC2758096  PMID:19371806  
  39. Sugatani T, Hruska KA. Impaired micro-RNA pathways diminish osteoclast differentiation and function. J Biol Chem. 2009;284(7):4667-78. doi:10.1074/jbc.M805777200  PMCID:PMC2640963  PMID:19059913  
  40. Mathew S, Lund RJ, Chaudhary LR, Geurs T, Hruska KA. Vitamin D receptor activators can protect against vascular calcification. J Am Soc Nephrol. 2008;19(8):1509-19. doi:10.1681/ASN.2007080902  PMCID:PMC2488263  PMID:18448587  
  41. Hruska KA, Mathew S, Lund R, Qiu P, Pratt R. Hyperphosphatemia of chronic kidney disease. Kidney Int. 2008;74(2):148-57. doi:10.1038/ki.2008.130  PMCID:PMC2735026  PMID:18449174  
  42. Mathew S, Tustison KS, Sugatani T, Chaudhary LR, Rifas L, Hruska KA. The mechanism of phosphorus as a cardiovascular risk factor in CKD. J Am Soc Nephrol. 2008;19(6):1092-105. doi:10.1681/ASN.2007070760  PMCID:PMC2396927  PMID:18417722  
  43. Hruska KA, Mathew S, Lund R. Osteoporosis and cardiovascular disease: lessons from chronic kidney disease. Clin Cases Miner Bone Metab. 2008;5(1):35-9. PMCID:PMC2781186  PMID:22460843  
  44. De Petris L, Hruska KA, Chiechio S, Liapis H. Bone morphogenetic protein-7 delays podocyte injury due to high glucose. Nephrol Dial Transplant. 2007;22(12):3442-50. doi:10.1093/ndt/gfm503  PMID:17686813  
  45. Hruska KA, Saab G, Mathew S, Lund R. Renal osteodystrophy, phosphate homeostasis, and vascular calcification. Semin Dial. 2007;20(4):309-15. PMID:17635820  
  46. Sugatani T, Hruska KA. MicroRNA-223 is a key factor in osteoclast differentiation. J Cell Biochem. 2007;101(4):996-9. doi:10.1002/jcb.21335  PMID:17471500  
  47. Mathew S, Lund RJ, Strebeck F, Tustison KS, Geurs T, Hruska KA. Reversal of the adynamic bone disorder and decreased vascular calcification in chronic kidney disease by sevelamer carbonate therapy. J Am Soc Nephrol. 2007;18(1):122-30. doi:10.1681/ASN.2006050490  PMID:17182886  
  48. Mathew S, Davies M, Lund R, Saab G, Hruska KA. Function and effect of bone morphogenetic protein-7 in kidney bone and the bone-vascular links in chronic kidney disease. Eur J Clin Invest. 2006;36 Suppl 2:43-50. doi:10.1111/j.1365-2362.2006.01663.x  PMID:16884397  
  49. Hendy GN, Hruska KA, Mathew S, Goltzman D. New insights into mineral and skeletal regulation by active forms of vitamin D. Kidney Int. 2006;69(2):218-23. doi:10.1038/  PMID:16408109  
  50. Lund RJ, Davies MR, Mathew S, Hruska KA. New discoveries in the pathogenesis of renal osteodystrophy. J Bone Miner Metab. 2006;24(2):169-71. doi:10.1007/s00774-005-0666-8  PMID:16502127  
  51. Hruska KA, Mathew S, Davies MR, Lund RJ. Connections between vascular calcification and progression of chronic kidney disease: therapeutic alternatives. Kidney Int Suppl. 2005;(99):S142-51. doi:10.1111/j.1523-1755.2005.09926.x  PMID:16336568  
  52. Surendran K, Schiavi S, Hruska KA. Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol. 2005;16(8):2373-84. doi:10.1681/ASN.2004110949  PMID:15944336  
  53. Hruska KA, Mathew S, Saab G. Bone morphogenetic proteins in vascular calcification. Circ Res. 2005;97(2):105-14. doi:10.1161/01.RES.00000175571.53833.6c  PMID:16037577  
  54. Jendrisak MD, Hruska K, Wagner J, Chandler D, Kappel D. Hospital-independent organ recovery from deceased donors: a two-year experience. Am J Transplant. 2005;5(5):1105-10. doi:10.1111/j.1600-6143.2005.00804.x  PMID:15816893  
  55. Davies MR, Lund RJ, Mathew S, Hruska KA. Low turnover osteodystrophy and vascular calcification are amenable to skeletal anabolism in an animal model of chronic kidney disease and the metabolic syndrome. J Am Soc Nephrol. 2005;16(4):917-28. doi:10.1681/ASN.2004100835  PMID:15743994  
  56. Sugatani T, Hruska KA. Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors. J Biol Chem. 2005;280(5):3583-9. doi:10.1074/jbc.M410480200  PMID:15545269  
  57. Lu Y, Adkisson HD, Bogdanske J, Kalscheur V, Maloney W, Cheung R, Grodzinsky AJ, Hruska KA, Markel MD. In vivo transplantation of neonatal ovine neocartilage allografts: determining the effectiveness of tissue transglutaminase. J Knee Surg. 2005;18(1):31-42. PMID:15742595  
  58. Li T, Surendran K, Zawaideh MA, Mathew S, Hruska KA. Bone morphogenetic protein 7: a novel treatment for chronic renal and bone disease. Curr Opin Nephrol Hypertens. 2004;13(4):417-22. PMID:15199292  
  59. Biswas RS, Baker D, Hruska KA, Chellaiah MA. Polyphosphoinositides-dependent regulation of the osteoclast actin cytoskeleton and bone resorption. BMC Cell Biol. 2004;5:19. doi:10.1186/1471-2121-5-19  PMCID:PMC441372  PMID:15142256  
  60. Chaudhary LR, Hofmeister AM, Hruska KA. Differential growth factor control of bone formation through osteoprogenitor differentiation. Bone. 2004;34(3):402-11. doi:10.1016/j.bone.2003.11.014  PMID:15003788  
  61. Goodman WG, London G, Amann K, Block GA, Giachelli C, Hruska KA, Ketteler M, Levin A, Massy Z, McCarron DA, Raggi P, Shanahan CM, Yorioka N, Vascular Calcification Work Group. Vascular calcification in chronic kidney disease. Am J Kidney Dis. 2004;43(3):572-9. PMID:14981617  
  62. Lund RJ, Davies MR, Brown AJ, Hruska KA. Successful treatment of an adynamic bone disorder with bone morphogenetic protein-7 in a renal ablation model. J Am Soc Nephrol. 2004;15(2):359-69. PMID:14747382  
  63. Nochi H, Sung JH, Lou J, Adkisson HD, Maloney WJ, Hruska KA. Adenovirus mediated BMP-13 gene transfer induces chondrogenic differentiation of murine mesenchymal progenitor cells. J Bone Miner Res. 2004;19(1):111-22. doi:10.1359/jbmr.2004.19.1.111  PMID:14753743  
  64. Hruska KA, Saab G, Chaudhary LR, Quinn CO, Lund RJ, Surendran K. Kidney-bone, bone-kidney, and cell-cell communications in renal osteodystrophy. Semin Nephrol. 2004;24(1):25-38. PMID:14730507  
  65. Walling HW, Raggatt LJ, Irvine DW, Barmina OY, Toledano JE, Goldring MB, Hruska KA, Adkisson HD, Burdge RE, Gatt CJ Jr, Harwood DA, Partridge NC. Impairment of the collagenase-3 endocytotic receptor system in cells from patients with osteoarthritis. Osteoarthritis Cartilage. 2003;11(12):854-63. PMID:14629961  
  66. Sugatani T, Alvarez UM, Hruska KA. Activin A stimulates IkappaB-alpha/NFkappaB and RANK expression for osteoclast differentiation, but not AKT survival pathway in osteoclast precursors. J Cell Biochem. 2003;90(1):59-67. doi:10.1002/jcb.10613  PMID:12938156  
  67. Chellaiah MA, Biswas RS, Rittling SR, Denhardt DT, Hruska KA. Rho-dependent Rho kinase activation increases CD44 surface expression and bone resorption in osteoclasts. J Biol Chem. 2003;278(31):29086-97. doi:10.1074/jbc.M211074200  PMID:12730217  
  68. Krishnamurthy MS, Hruska KA, Chandhoke PS. The urinary response to an oral oxalate load in recurrent calcium stone formers. J Urol. 2003;169(6):2030-3. doi:10.1097/01.ju.0000062527.37579.49  PMID:12771711  
  69. Davies MR, Lund RJ, Hruska KA. BMP-7 is an efficacious treatment of vascular calcification in a murine model of atherosclerosis and chronic renal failure. J Am Soc Nephrol. 2003;14(6):1559-67. PMID:12761256  
  70. Wang S, Chen Q, Simon TC, Strebeck F, Chaudhary L, Morrissey J, Liapis H, Klahr S, Hruska KA. Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy. Kidney Int. 2003;63(6):2037-49. doi:10.1046/j.1523-1755.2003.00035.x  PMID:12753291  
  71. Rojas E, Carlini RG, Clesca P, Arminio A, Suniaga O, De Elguezabal K, Weisinger JR, Hruska KA, Bellorin-Font E. The pathogenesis of osteodystrophy after renal transplantation as detected by early alterations in bone remodeling. Kidney Int. 2003;63(5):1915-23. doi:10.1046/j.1523-1755.2003.00938.x  PMID:12675872  
  72. Chaudhary LR, Hruska KA. Inhibition of cell survival signal protein kinase B/Akt by curcumin in human prostate cancer cells. J Cell Biochem. 2003;89(1):1-5. doi:10.1002/jcb.10495  PMID:12682902  
  73. Saab G, Mathew S, Chaudhary LR, Hruska KA. Post-transplant osteodystrophy in the era of the K/DOQI guidelines. Dialysis & Transplantation. 2003;32:651-658. 
  74. Gupta A, Lee BS, Khadeer MA, Tang Z, Chellaiah M, Abu-Amer Y, Goldknopf J, Hruska KA. Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast. J Bone Miner Res. 2003;18(4):669-85. doi:10.1359/jbmr.2003.18.4.669  PMID:12674328  
  75. Chellaiah MA, Hruska KA. The integrin alpha(v)beta(3) and CD44 regulate the actions of osteopontin on osteoclast motility. Calcif Tissue Int. 2003;72(3):197-205. doi:10.1007/s00223-002-1025-6  PMID:12469249  
  76. Sugatani T, Alvarez U, Hruska KA. PTEN regulates RANKL- and osteopontin-stimulated signal transduction during osteoclast differentiation and cell motility. J Biol Chem. 2003;278(7):5001-8. doi:10.1074/jbc.M209299200  PMID:12460992  
  77. Uchida K, Chaudhary LR, Sugimura Y, Adkisson HD, Hruska KA. Proprotein convertases regulate activity of prostate epithelial cell differentiation markers and are modulated in human prostate cancer cells. J Cell Biochem. 2003;88(2):394-9. doi:10.1002/jcb.10327  PMID:12520542  
  78. Chellaiah MA, Kizer N, Biswas R, Alvarez U, Strauss-Schoenberger J, Rifas L, Rittling SR, Denhardt DT, Hruska KA. Osteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expression. Mol Biol Cell. 2003;14(1):173-89. doi:10.1091/mbc.E02-06-0354  PMCID:PMC140236  PMID:12529435  
  79. Jendrisak MD, Hruska K, Wagner J, Chandler D, Kappel D. Cadaveric-donor organ recovery at a hospital-independent facility. Transplantation. 2002;74(7):978-82. PMID:12394841  
  80. Hruska KA. Treatment of chronic tubulointerstitial disease: a new concept. Kidney Int. 2002;61(5):1911-22. doi:10.1046/j.1523-1755.2002.00331.x  PMID:11967050  
  81. Klahr S, Morrissey J, Hruska K, Wang S, Chen Q. New approaches to delay the progression of chronic renal failure. Kidney Int Suppl. 2002;(80):23-6. doi:10.1046/j.1523-1755.61.s80.16.x  PMID:11982808  
  82. González EA, Lund RJ, Martin KJ, McCartney JE, Tondravi MM, Sampath TK, Hruska KA. Treatment of a murine model of high-turnover renal osteodystrophy by exogenous BMP-7. Kidney Int. 2002;61(4):1322-31. doi:10.1046/j.1523-1755.2002.00258.x  PMID:11918739  
  83. Lund RJ, Davies MR, Hruska KA. Bone morphogenetic protein-7: an anti-fibrotic morphogenetic protein with therapeutic importance in renal disease. Curr Opin Nephrol Hypertens. 2002;11(1):31-6. PMID:11753084  
  84. Morrissey J, Hruska K, Guo G, Wang S, Chen Q, Klahr S. Bone morphogenetic protein-7 improves renal fibrosis and accelerates the return of renal function. J Am Soc Nephrol. 2002;13 Suppl 1:S14-21. PMID:11792757  
  85. Chellaiah MA, Biswas RS, Yuen D, Alvarez UM, Hruska KA. Phosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolin. J Biol Chem. 2001;276(50):47434-44. doi:10.1074/jbc.M107494200  PMID:11577104  
  86. Gupta A, Tenenhouse HS, Hoag HM, Wang D, Khadeer MA, Namba N, Feng X, Hruska KA. Identification of the type II Na(+)-Pi cotransporter (Npt2) in the osteoclast and the skeletal phenotype of Npt2-/- mice. Bone. 2001;29(5):467-76. PMID:11704500  
  87. Adkisson HD, Gillis MP, Davis EC, Maloney W, Hruska KA. In vitro generation of scaffold independent neocartilage. Clin Orthop Relat Res. 2001;(391 Suppl):S280-94. PMID:11603712  
  88. Soga N, Namba N, McAllister S, Cornelius L, Teitelbaum SL, Dowdy SF, Kawamura J, Hruska KA. Rho family GTPases regulate VEGF-stimulated endothelial cell motility. Exp Cell Res. 2001;269(1):73-87. doi:10.1006/excr.2001.5295  PMID:11525641  
  89. Davies MR, Hruska KA. Pathophysiological mechanisms of vascular calcification in end-stage renal disease. Kidney Int. 2001;60(2):472-9. doi:10.1046/j.1523-1755.2001.060002472.x  PMID:11473629  
  90. Vocero-Akbari, A., Chellaiah, M.A., Hruska, K.A., Dowdy, S.F. Protein transduction: delivery of Tat-GTPase fusion proteins into mammalian cells Methods Enzymol. 2001;332:36-49. 
  91. Bennett BD, Alvarez U, Hruska KA. Receptor-operated osteoclast calcium sensing. Endocrinology. 2001;142(5):1968-74. doi:10.1210/endo.142.5.8125  PMID:11316762  
  92. Ihara H, Denhardt DT, Furuya K, Yamashita T, Muguruma Y, Tsuji K, Hruska KA, Higashio K, Enomoto S, Nifuji A, Rittling SR, Noda M. Parathyroid hormone-induced bone resorption does not occur in the absence of osteopontin. J Biol Chem. 2001;276(16):13065-71. doi:10.1074/jbc.M010938200  PMID:11278791  
  93. Chaudhary LR, Hruska KA. The cell survival signal Akt is differentially activated by PDGF-BB, EGF, and FGF-2 in osteoblastic cells. J Cell Biochem. 2001;81(2):304-11. PMID:11241670  
  94. Soga N, Connolly JO, Chellaiah M, Kawamura J, Hruska KA. Rac regulates vascular endothelial growth factor stimulated motility. Cell Commun Adhes. 2001;8(1):1-13. PMID:11775025  
  95. Wozniak M, Fausto A, Carron CP, Meyer DM, Hruska KA. Mechanically strained cells of the osteoblast lineage organize their extracellular matrix through unique sites of alphavbeta3-integrin expression. J Bone Miner Res. 2000;15(9):1731-45. doi:10.1359/jbmr.2000.15.9.1731  PMID:10976993  
  96. Schwarze SR, Hruska KA, Dowdy SF. Protein transduction: unrestricted delivery into all cells? Trends Cell Biol. 2000;10(7):290-5. PMID:10856932  
  97. Civitelli R, Hruska K, Ralston S. Dawning of a New Era at CTI Calcif Tissue Int. 2000;67(1):1. PMID:10908404  
  98. Hruska KA, Guo G, Wozniak M, Martin D, Miller S, Liapis H, Loveday K, Klahr S, Sampath TK, Morrissey J. Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction. Am J Physiol Renal Physiol. 2000;279(1):F130-43. PMID:10894795  
  99. Hruska KA. Pathophysiology of renal osteodystrophy Pediatr Nephrol. 2000;14:636-640. 
  100. Adkisson HD, Strauss-Schoenberger J, Gillis M, Wilkins R, Jackson M, Hruska KA. Rapid quantitative bioassay of osteoinduction. J Orthop Res. 2000;18(3):503-11. doi:10.1002/jor.1100180326  PMID:10937641  
  101. Connolly JO, Soga N, Guo XL, Alvarez U, Hruska KA. Rac is essential in the transformation of endothelial cells by polyoma middle T. Cell Adhes Commun. 2000;7(5):409-22. PMID:10830619  
  102. Chellaiah MA, Soga N, Swanson S, McAllister S, Alvarez U, Wang D, Dowdy SF, Hruska KA. Rho-A is critical for osteoclast podosome organization, motility, and bone resorption. J Biol Chem. 2000;275(16):11993-2002. PMID:10766830  
  103. Cheng SL, Lai CF, Fausto A, Chellaiah M, Feng X, McHugh KP, Teitelbaum SL, Civitelli R, Hruska KA, Ross FP, Avioli LV. Regulation of alphaVbeta3 and alphaVbeta5 integrins by dexamethasone in normal human osteoblastic cells. J Cell Biochem. 2000;77(2):265-76. PMID:10723092  
  104. Chellaiah M, Kizer N, Silva M, Alvarez U, Kwiatkowski D, Hruska KA. Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength. J Cell Biol. 2000;148(4):665-78. PMCID:PMC2169374  PMID:10684249  
  105. Kizer N, Harter L, Hruska K, Alvarez U, Duncan R. Volume regulatory decrease in UMR-106.01 cells is mediated by specific alpha1 subunits of L-type calcium channels. Cell Biochem Biophys. 1999;31(1):65-79. doi:10.1007/BF02738155  PMID:10505668  
  106. Hruska KA. New insights related to aging and renal osteodystrophy. Geriatr Nephrol Urol. 1999;9(1):49-56. PMID:10435227  
  107. Chellaiah MA, Hruska KA. Osteopontin. Drug News Perspect. 1998;11(6):350-5. PMID:15616623  
  108. Powell T, Hsu FF, Turk J, Hruska K. Ma-huang strikes again: ephedrine nephrolithiasis. Am J Kidney Dis. 1998;32(1):153-9. PMID:9669437  
  109. Stickle D, Cole B, Hock K, Hruska KA, Scott MG. Correlation of plasma concentrations of cystatin C and creatinine to inulin clearance in a pediatric population. Clin Chem. 1998;44(6 Pt 1):1334-8. PMID:9625061  
  110. Chellaiah M, Fitzgerald C, Alvarez U, Hruska K. c-Src is required for stimulation of gelsolin-associated phosphatidylinositol 3-kinase. J Biol Chem. 1998;273(19):11908-16. PMID:9565618  
  111. Teti A, Taranta A, Migliaccio S, Degiorgi A, Santandrea E, Villanova I, Faraggiana T, Chellaiah M, Hruska KA. Colony stimulating factor-1-induced osteoclast spreading depends on substrate and requires the vitronectin receptor and the c-src proto-oncogene. J Bone Miner Res. 1998;13(1):50-8. doi:10.1359/jbmr.1998.13.1.50  PMID:9443790  
  112. Onishi T, Zhang W, Cao X, Hruska K. The mitogenic effect of parathyroid hormone is associated with E2F-dependent activation of cyclin-dependent kinase 1 (cdc2) in osteoblast precursors. J Bone Miner Res. 1997;12(10):1596-605. doi:10.1359/jbmr.1997.12.10.1596  PMID:9333120  
  113. Rifas L, Cheng S, Halstead LR, Gupta A, Hruska KA, Avioli LV. Skeletal casein kinase activity defect in the HYP mouse. Calcif Tissue Int. 1997;61(3):256-9. PMID:9262518  
  114. Gupta A, Guo XL, Alvarez UM, Hruska KA. Regulation of sodium-dependent phosphate transport in osteoclasts. J Clin Invest. 1997;100(3):538-49. doi:10.1172/JCI119563  PMCID:PMC508220  PMID:9239400  
  115. Endsley JK, Phillips JA 3rd, Hruska KA, Denneberg T, Carlson J, George AL Jr. Genomic organization of a human cystine transporter gene (SLC3A1) and identification of novel mutations causing cystinuria. Kidney Int. 1997;51(6):1893-9. PMID:9186880  
  116. Onishi T, Hruska K. Expression of p27Kip1 in osteoblast-like cells during differentiation with parathyroid hormone. Endocrinology. 1997;138(5):1995-2004. doi:10.1210/endo.138.5.5146  PMID:9112398  
  117. Rogers SA, Padanilam BJ, Hruska KA, Giachelli CM, Hammerman MR. Metanephric osteopontin regulates nephrogenesis in vitro. Am J Physiol. 1997;272(4 Pt 2):F469-76. PMID:9140047  
  118. Hruska KA. Renal osteodystrophy. Baillieres Clin Endocrinol Metab. 1997;11(1):165-94. PMID:9222491  
  119. Kizer N, Guo XL, Hruska K. Reconstitution of stretch-activated cation channels by expression of the alpha-subunit of the epithelial sodium channel cloned from osteoblasts. Proc Natl Acad Sci U S A. 1997;94(3):1013-8. PMCID:PMC19631  PMID:9023374  
  120. Kim YS, MacDonald PN, Dedhar S, Hruska KA. Association of 1 alpha,25-dihydroxyvitamin D3-occupied vitamin D receptors with cellular membrane acceptance sites. Endocrinology. 1996;137(9):3649-58. doi:10.1210/endo.137.9.8756529  PMID:8756529  
  121. Chellaiah M, Fitzgerald C, Filardo EJ, Cheresh DA, Hruska KA. Osteopontin activation of c-src in human melanoma cells requires the cytoplasmic domain of the integrin alpha v-subunit. Endocrinology. 1996;137(6):2432-40. doi:10.1210/endo.137.6.8641196  PMID:8641196  
  122. Chellaiah M, Hruska K. Osteopontin stimulates gelsolin-associated phosphoinositide levels and phosphatidylinositol triphosphate-hydroxyl kinase. Mol Biol Cell. 1996;7(5):743-53. PMCID:PMC275927  PMID:8744948  
  123. Gupta A, Miyauchi A, Fujimori A, Hruska KA. Phosphate transport in osteoclasts: a functional and immunochemical characterization. Kidney Int. 1996;49(4):968-74. PMID:8691746  
  124. Duncan RL, Kizer N, Barry EL, Friedman PA, Hruska KA. Antisense oligodeoxynucleotide inhibition of a swelling-activated cation channel in osteoblast-like osteosarcoma cells. Proc Natl Acad Sci U S A. 1996;93(5):1864-9. PMCID:PMC39873  PMID:8700850  
  125. Gupta A, Edwards JC, Hruska KA. Cellular distribution and regulation of NHE-1 isoform of the NA-H exchanger in the avian osteoclast. Bone. 1996;18(2):87-95. PMID:8833201  
  126. Hruska KA, Teitelbaum SL. Renal osteodystrophy. N Engl J Med. 1995;333(3):166-74. doi:10.1056/NEJM199507203330307  PMID:7791820  
  127. Rifas L, Gupta A, Hruska KA, Avioli LV. Altered osteoblast gluconeogenesis in X-linked hypophosphatemic mice is associated with a depressed intracellular pH. Calcif Tissue Int. 1995;57(1):60-3. PMID:7671167  
  128. Hruska KA, Rolnick F, Huskey M, Alvarez U, Cheresh D. Engagement of the osteoclast integrin alpha v beta 3 by osteopontin stimulates phosphatidylinositol 3-hydroxyl kinase activity. Ann N Y Acad Sci. 1995;760:151-65. PMID:7540372  
  129. Hruska KA, Rifas L, Cheng SL, Gupta A, Halstead L, Avioli L. X-linked hypophosphatemic rickets and the murine Hyp homologue. Am J Physiol. 1995;268(3 Pt 2):F357-62. PMID:7900834  
  130. Harter LV, Hruska KA, Duncan RL. Human osteoblast-like cells respond to mechanical strain with increased bone matrix protein production independent of hormonal regulation. Endocrinology. 1995;136(2):528-35. doi:10.1210/endo.136.2.7530647  PMID:7530647  
  131. Hruska KA, Chellaiah M, Rolnick F, Yamakawa K, Gupta A. Recent progress in signal transduction related to bone remodeling and aging. Calcif Tissue Int. 1995;56 Suppl 1:S35-8. doi:10.1007/BF03354651  PMID:25773034  
  132. Hruska KA, Chellaiah M, Rolnick F, Yamakawa K, Gupta A. Recent progress in signal transduction related to bone remodeling and aging. Calcif Tissue Int. 1995;56 Suppl 1:S35-8. doi:10.1007/BF03354651  PMID:25773034  
  133. Duncan RL, Hruska KA. Chronic, intermittent loading alters mechanosensitive channel characteristics in osteoblast-like cells. Am J Physiol. 1994;267(6 Pt 2):F909-16. PMID:7528987  
  134. Gupta A, Hruska KA, Tuan TL. Angiotensin II binding to human embryonic lung fibroblasts causes transient changes in cytosolic calcium and promotes fibrin gel contraction. Indian J Exp Biol. 1994;32(9):603-6. PMID:7814036  
  135. Gupta A, Hruska KA, Martin KJ. Neurotensin binding to human embryonic lung fibroblasts. J Recept Res. 1994;14(5):307-17. PMID:7815388  
  136. Yamakawa K, Duncan R, Hruska KA. An Arg-Gly-Asp peptide stimulates Ca2+ efflux from osteoclast precursors through a novel mechanism. Am J Physiol. 1994;266(4 Pt 2):F651-7. PMID:8184899  
  137. Fujimori A, Miyauchi A, Hruska KA, Martin KJ, Avioli LV, Civitelli R. Desensitization of calcium messenger system in parathyroid hormone-stimulated opossum kidney cells. Am J Physiol. 1993;264(6 Pt 1):E918-24. PMID:8392807  
  138. Medhora MM, Teitelbaum S, Chappel J, Alvarez J, Mimura H, Ross FP, Hruska K. 1 alpha,25-dihydroxyvitamin D3 up-regulates expression of the osteoclast integrin alpha v beta 3. J Biol Chem. 1993;268(2):1456-61. PMID:7678259  
  139. Duncan RL, Hruska KA, Misler S. Parathyroid hormone activation of stretch-activated cation channels in osteosarcoma cells (UMR-106.01). FEBS Lett. 1992;307(2):219-23. PMID:1379539  
  140. Moskowitz DW, Hruska KA. Ca2+ uptake by endoplasmic reticulum of renal cortex. II. Effects of uninephrectomy and parathyroidectomy. Calcif Tissue Int. 1992;51(1):42-7. PMID:1393776  
  141. Moskowitz DW, Hruska KA. Ca2+ uptake by endoplasmic reticulum of renal cortex. I. Ionic requirements and regulation in vitro. Calcif Tissue Int. 1992;51(1):35-41. PMID:1327465  
  142. Hardy RW, Ladenson JH, Hruska KA, Jiwa AH, McDonald JM. The effects of extracellular calcium and epinephrine on cytosolic-free calcium in single rat adipocytes. Endocrinology. 1992;130(6):3694-702. doi:10.1210/endo.130.6.1597165  PMID:1597165  
  143. Civitelli R, Fujimori A, Bernier SM, Warlow PM, Goltzman D, Hruska KA, Avioli LV. Heterogeneous intracellular free calcium responses to parathyroid hormone correlate with morphology and receptor distribution in osteogenic sarcoma cells. Endocrinology. 1992;130(4):2392-400. doi:10.1210/endo.130.4.1312456  PMID:1312456  
  144. Gupta A, Bastani B, Chardin P, Hruska KA. Localization of ral, a small Mr GTP-binding protein, to collecting duct cells in bovine and rat kidney. Am J Physiol. 1991;261(6 Pt 2):F1063-70. PMID:1750519  
  145. Miyauchi A, Alvarez J, Greenfield EM, Teti A, Grano M, Colucci S, Zambonin-Zallone A, Ross FP, Teitelbaum SL, Cheresh D. Recognition of osteopontin and related peptides by an alpha v beta 3 integrin stimulates immediate cell signals in osteoclasts. J Biol Chem. 1991;266(30):20369-74. PMID:1939092  
  146. Allon M, Hruska KA. Renal adaptation to dietary phosphate restriction in rats. Interactions with insulin and calcitriol. Diabetes. 1991;40(9):1134-40. PMID:1936621  
  147. Gupta A, Bastani B, Purcell H, Hruska KA. Identification and localization of pertussis toxin-sensitive GTP-binding proteins in bovine kidney glomeruli. J Am Soc Nephrol. 1991;2(2):172-8. PMID:1954330  
  148. Tanaka H, Hruska KA, Seino Y, Malone JD, Nishii Y, Teitelbaum SL. Disassociation of the macrophage-maturational effects of vitamin D from respiratory burst priming. J Biol Chem. 1991;266(17):10888-92. PMID:1645714  
  149. Obialo CI, Clayman RV, Matts JP, Fitch LL, Buchwald H, Gillis M, Hruska KA. Pathogenesis of nephrolithiasis post-partial ileal bypass surgery: case-control study. The POSCH Group. Kidney Int. 1991;39(6):1249-54. PMID:1895677  
  150. Gupta A, Martin KJ, Miyauchi A, Hruska KA. Regulation of cytosolic calcium by parathyroid hormone and oscillations of cytosolic calcium in fibroblasts from normal and pseudohypoparathyroid patients. Endocrinology. 1991;128(6):2825-36. doi:10.1210/endo-128-6-2825  PMID:1645251  
  151. Civitelli R, Hruska KA. Monitoring cytosolic calcium in renal epithelia. Special issue "Methods in Kidney Epithelial Cell Culture" J Tiss Cul Methods. 1991;13:217-228. 
  152. Hruska KA, Civitelli R, Duncan R, Avioli LV. Regulation of skeletal remodeling by parathyroid hormone. Contrib Nephrol. 1991;91:38-42. PMID:1800010  
  153. Miyauchi A, Hruska KA, Greenfield EM, Duncan R, Alvarez J, Barattolo R, Colucci S, Zambonin-Zallone A, Teitelbaum SL, Teti A. Osteoclast cytosolic calcium, regulated by voltage-gated calcium channels and extracellular calcium, controls podosome assembly and bone resorption. J Cell Biol. 1990;111(6 Pt 1):2543-52. PMCID:PMC2116358  PMID:1703539  
  154. Rothstein M, Obialo C, Hruska KA. Renal tubular acidosis. Endocrinol Metab Clin North Am. 1990;19(4):869-87. PMID:2081516  
  155. Civitelli R, Kim YS, Gunsten SL, Fujimori A, Huskey M, Avioli LV, Hruska KA. Nongenomic activation of the calcium message system by vitamin D metabolites in osteoblast-like cells. Endocrinology. 1990;127(5):2253-62. doi:10.1210/endo-127-5-2253  PMID:2226314  
  156. Miyauchi A, Dobre V, Rickmeyer M, Cole J, Forte L, Hruska KA. Stimulation of transient elevations in cytosolic Ca2+ is related to inhibition of Pi transport in OK cells. Am J Physiol. 1990;259(3 Pt 2):F485-93. PMID:2396674  
  157. Gupta A, Hruska KA, Wedner HJ. Phytohemagglutinin rapidly lyses S49 T-lymphoma cells and the cytotoxicity is not mediated by generation of cAMP or increase in cytosolic calcium. Biochem Biophys Res Commun. 1990;170(3):1035-43. PMID:2167667  
  158. Pacifici R, Rothstein M, Rifas L, Lau KH, Baylink DJ, Avioli LV, Hruska K. Increased monocyte interleukin-1 activity and decreased vertebral bone density in patients with fasting idiopathic hypercalciuria. J Clin Endocrinol Metab. 1990;71(1):138-45. doi:10.1210/jcem-71-1-138  PMID:2370292  
  159. Dunlay R, Hruska K. PTH receptor coupling to phospholipase C is an alternate pathway of signal transduction in bone and kidney. Am J Physiol. 1990;258(2 Pt 2):F223-31. PMID:2155534  
  160. Teitelbaum SL, Hruska KA. 1,25-Dihydroxycholecalciferol and macrophage differentiation with aging. Exp Gerontol. 1990;25(3-4):233-8. PMID:2171969  
  161. Civitelli R, Hruska KA, Shen V, Avioli LV. Cyclic AMP-dependent and calcium-dependent signals in parathyroid hormone function. Exp Gerontol. 1990;25(3-4):223-31. PMID:2171968  
  162. Civitelli R, Teitelbaum SL, Hruska KA, Lacey DL. IL-1 activates the Na+/H+ antiport in a murine T cell. J Immunol. 1989;143(12):4000-8. PMID:2556473  
  163. Teti A, Grano M, Colucci S, Argentino L, Barattolo R, Miyauchi A, Teitelbaum SL, Hruska KA, Zambonin Zallone A. Voltage dependent calcium channel expression in isolated osteoclasts. Boll Soc Ital Biol Sper. 1989;65(12):1115-8. PMID:2560636  
  164. Teti A, Barattolo R, Grano M, Colucci S, Argentino L, Teitelbaum SL, Hruska KA, Santacroce G, Zambonin Zallone A. Podosome expression in osteoclasts: influence of high extracellular calcium concentration. Boll Soc Ital Biol Sper. 1989;65(11):1039-43. PMID:2629823  
  165. Teti A, Blair HC, Schlesinger P, Grano M, Zambonin-Zallone A, Kahn AJ, Teitelbaum SL, Hruska KA. Extracellular protons acidify osteoclasts, reduce cytosolic calcium, and promote expression of cell-matrix attachment structures. J Clin Invest. 1989;84(3):773-80. doi:10.1172/JCI114235  PMCID:PMC329718  PMID:2547838  
  166. Civitelli R, Martin TJ, Fausto A, Gunsten SL, Hruska KA, Avioli LV. Parathyroid hormone-related peptide transiently increases cytosolic calcium in osteoblast-like cells: comparison with parathyroid hormone. Endocrinology. 1989;125(3):1204-10. doi:10.1210/endo-125-3-1204  PMID:2503365  
  167. Teti A, Grano M, Teitelbaum SL, Hruska KA, Colucci S, Zambonin Zallone A. Intracellular acidification induces decrease of cytosolic calcium in isolated osteoclasts. Boll Soc Ital Biol Sper. 1989;65(8):689-93. PMID:2803732  
  168. Karpinski E, Wu L, Civitelli R, Avioli LV, Hruska KA, Pang PK. A dihydropyridine-sensitive calcium channel in rodent osteoblastic cells. Calcif Tissue Int. 1989;45(1):54-7. PMID:2548684  
  169. Teti A, Grano M, Teitelbaum SL, Hruska KA, Colucci S, Zambonin Zallone A. Regulation of podosomes by intracellular pH in avian osteoclasts. Boll Soc Ital Biol Sper. 1989;65(7):597-601. PMID:2597415  
  170. Civitelli R, Hruska KA, Jeffrey JJ, Kahn AJ, Avioli LV, Partridge NC. Second messenger signaling in the regulation of collagenase production by osteogenic sarcoma cells. Endocrinology. 1989;124(6):2928-34. doi:10.1210/endo-124-6-2928  PMID:2542004  
  171. Suzuki Y, Hruska KA, Reid I, Alvarez UM, Avioli LV. Characterization of phospholipase C activity of the plasma membrane and cytosol of an osteoblast-like cell line. Am J Med Sci. 1989;297(3):135-44. PMID:2923133  
  172. Greenwald JE, Apkon M, Hruska KA, Needleman P. Stretch-induced atriopeptin secretion in the isolated rat myocyte and its negative modulation by calcium. J Clin Invest. 1989;83(3):1061-5. doi:10.1172/JCI113948  PMCID:PMC303784  PMID:2522102  
  173. Hruska KA, Bar-Shavit Z, Malone JD, Teitelbaum S. Ca2+ priming during vitamin D-induced monocytic differentiation of a human leukemia cell line. J Biol Chem. 1988;263(31):16039-44. PMID:3182781  
  174. Civitelli R, Reid IR, Westbrook S, Avioli LV, Hruska KA. PTH elevates inositol polyphosphates and diacylglycerol in a rat osteoblast-like cell line. Am J Physiol. 1988;255(5 Pt 1):E660-7. PMID:3263806  
  175. Scoble JE, Cragoe EJ Jr, Hruska KA. Na+-Ca2+ exchange and calcium permeability in canine basolateral membrane vesicles: the effects of dibutyryl cAMP and specific inhibitors. Biochim Biophys Acta. 1988;944(2):233-41. PMID:2846057  
  176. Filipponi P, Mannarelli C, Pacifici R, Grossi E, Moretti I, Tini S, Carloni C, Blass A, Morucci P, Hruska KA. Evidence for a prostaglandin-mediated bone resorptive mechanism in subjects with fasting hypercalciuria. Calcif Tissue Int. 1988;43(2):61-6. PMID:3142668  
  177. Reid IR, Civitelli R, Avioli LV, Hruska KA. Parathyroid hormone depresses cytosolic pH and DNA synthesis in osteoblast-like cells. Am J Physiol. 1988;255(1 Pt 1):E9-15. PMID:2839040  
  178. Goligorsky MS, Hruska KA. Hormonal modulation of cytoplasmic calcium concentration in renal tubular epithelium. Miner Electrolyte Metab. 1988;14(1):58-70. PMID:3279296  
  179. Shen V, Hruska K, Avioli LV. Characterization of a (Ca2+ + Mg2+)-ATPase system in the osteoblast plasma membrane. Bone. 1988;9(5):325-9. PMID:2974293  
  180. Goligorsky MS, Osborne D, Howard T, Hruska KA, Karl IE. Hormonal regulation of gluconeogenesis in cultured proximal tubular cells: role of cytosolic calcium. Am J Physiol. 1987;253(5 Pt 2):F802-9. PMID:3688237  
  181. Hruska KA. Regulation of renal phosphate reabsorption: concepts in evolution. Pediatr Nephrol. 1987;1(4):657-63. PMID:3153347  
  182. Reid IR, Civitelli R, Halstead LR, Avioli LV, Hruska KA. Parathyroid hormone acutely elevates intracellular calcium in osteoblastlike cells. Am J Physiol. 1987;253(1 Pt 1):E45-51. PMID:3037917  
  183. Civitelli R, Reid IR, Halstead LR, Avioli LV, Hruska KA. Membrane potential and cation content of osteoblast-like cells (UMR 106) assessed by fluorescent dyes. J Cell Physiol. 1987;131(3):434-41. doi:10.1002/jcp.1041310316  PMID:3474236  
  184. Reid IR, Civitelli R, Westbrook SL, Avioli LV, Hruska KA. Cytoplasmic pH regulation in canine renal proximal tubule cells. Kidney Int. 1987;31(5):1113-20. PMID:3599651  
  185. Bar-Shavit R, Hruska KA, Kahn AJ, Wilner GD. Thrombin chemotactic stimulation of HL-60 cells: studies on thrombin responsiveness as a function of differentiation. J Cell Physiol. 1987;131(2):255-61. doi:10.1002/jcp.1041310216  PMID:3034923  
  186. Goligorsky MS, Menton DN, Hruska KA. Effects of phorbol ester, cyclic nucleotides, and ionomycin on ion transport and brush-border topography in cultured renal proximal tubular cells. Ann NY Acad Sci. 1987;494 :208-210. 
  187. Martin KJ, Finch JL, Hruska K, Slatopolsky E. Effect of biological activity of PTH on its peripheral metabolism in the rat. Kidney Int. 1987;31(4):937-40. PMID:3586500  
  188. Suzuki Y, Fausto A, Hruska KA, Avioli LV. Stimulation of phosphatidylcholine biosynthesis in diabetic hypertrophic kidneys. Endocrinology. 1987;120(2):595-601. doi:10.1210/endo-120-2-595  PMID:3803292  
  189. Kurnik BR, Huskey M, Hruska KA. 1,25-Dihydroxycholecalciferol stimulates renal phosphate transport by directly altering membrane phosphatidylcholine composition. Biochim Biophys Acta. 1987;917(1):81-5. PMID:3790614  
  190. Hruska KA, Moskowitz D, Esbrit P, Civitelli R, Westbrook S, Huskey M. Stimulation of inositol trisphosphate and diacylglycerol production in renal tubular cells by parathyroid hormone. J Clin Invest. 1987;79(1):230-9. doi:10.1172/JCI112788  PMCID:PMC424029  PMID:3025260  
  191. Goligorsky MS, Duncan RL, Westbrook S, Reinach P, Hruska KA. Demonstration of a direct effect of atrial natriuretic factor on epithelium: study in cultured pig kidney cells. Miner Electrolyte Metab. 1987;13(1):51-6. PMID:2953957  
  192. Goligorsky MS, Loftus DJ, Hruska KA. Cytoplasmic calcium in individual proximal tubular cells in culture. Am J Physiol. 1986;251(5 Pt 2):F938-44. PMID:3777189  
  193. Goligorsky MS, Hruska KA, Loftus DJ, Elson EL. Alpha 1-adrenergic stimulation and cytoplasmic free calcium concentration in cultured renal proximal tubular cells: evidence for compartmentalization of quin-2 and fura-2. J Cell Physiol. 1986;128(3):466-74. doi:10.1002/jcp.1041280316  PMID:3755726  
  194. Hruska KA, Goligorsky M, Scoble J, Tsutsumi M, Westbrook S, Moskowitz D. Effects of parathyroid hormone on cytosolic calcium in renal proximal tubular primary cultures. Am J Physiol. 1986;251(2 Pt 2):F188-98. PMID:3740268  
  195. Kurnik BR, Huskey M, Hagerty D, Hruska KA. Vitamin D metabolites stimulate phosphatidylcholine transfer to renal brush-border membranes. Biochim Biophys Acta. 1986;858(1):47-55. PMID:3754768  
  196. Delmez JA, Fallon MD, Harter HR, Hruska KA, Slatopolsky E, Teitelbaum SL. Does strict phosphorus control precipitate renal osteomalacia? J Clin Endocrinol Metab. 1986;62(4):747-52. doi:10.1210/jcem-62-4-747  PMID:3949954  
  197. Shayman JA, Hruska KA, Morrison AR. Bradykinin stimulates increased intracellular calcium in papillary collecting tubules of the rabbit. Biochem Biophys Res Commun. 1986;134(1):299-304. PMID:3080988  
  198. Scoble JE, Moskowitz D, Hruska KA. Dibutryladenosine 3',5'-cyclic monophosphate (dBcAMP) does not mimic the action of parathyroid hormone (PTH) on canine proximal tubular basolateral membrane Na+:Ca2+. Adv Exp Med Biol. 1986;208:537-41. PMID:3031954  
  199. Kurnik BR, Huskey M, Hruska KA. The direct effect of 1,25-dihydroxycholecalciferol on membrane phospholipid composition and phosphate transport. Adv Exp Med Biol. 1986;208:115-24. PMID:3565143  
  200. Bar-Shavit R, Hruska KA, Kahn AJ, Wilner GD. Hormone-like activity of human thrombin. Ann N Y Acad Sci. 1986;485:335-48. PMID:3032049  
  201. Goligorsky MS, Menton DN, Hruska KA. Parathyroid hormone-induced changes of the brush border topography and cytoskeleton in cultured renal proximal tubular cells. J Membr Biol. 1986;92(2):151-62. PMID:3761360  
  202. Goligorsky MS, Hruska KA. Transcytosis in cultured proximal tubular cells. J Membr Biol. 1986;93(3):237-47. PMID:3820280  
  203. Kurnik BR, Hruska KA. Mechanism of stimulation of renal phosphate transport by 1,25-dihydroxycholecalciferol. Biochim Biophys Acta. 1985;817(1):42-50. PMID:3839137  
  204. Tsutsumi M, Alvarez U, Avioli LV, Hruska KA. Effect of 1,25-dihydroxyvitamin D3 on phospholipid composition of rat renal brush border membrane. Am J Physiol. 1985;249(1 Pt 2):F117-23. PMID:3839347  
  205. Scoble JE, Mills S, Hruska KA. Calcium transport in canine renal basolateral membrane vesicles. Effects of parathyroid hormone. J Clin Invest. 1985;75(4):1096-105. doi:10.1172/JCI111803  PMCID:PMC425432  PMID:3988932  
  206. Pohlman T, Hruska KA, Menon M. Renal tubular acidosis. J Urol. 1984;132(3):431-6. PMID:6471171  
  207. Kurnik BR, Hruska KA. Effects of 1,25-dihydroxycholecalciferol on phosphate transport in vitamin D-deprived rats. Am J Physiol. 1984;247(1 Pt 2):F177-84. PMID:6331201  
  208. Hruska KA, Khalifa S, Meltzer V, Martin K. Calcium as a mediator of the physiological and pathophysiological effects of parathyroid hormone. Semin Nephrol. 1984;4:159-173. 
  209. Khalifa S, Mills S, Hruska KA. Stimulation of calcium uptake by parathyroid hormone in renal brush-border membrane vesicles. Relationship to membrane phosphorylation. J Biol Chem. 1983;258(23):14400-6. PMID:6643490  
  210. Hruska KA, Mills SC, Khalifa S, Hammerman MR. Phosphorylation of renal brush-border membrane vesicles. Effect on calcium uptake and membrane content of polyphosphoinositides. J Biol Chem. 1983;258(4):2501-7. PMID:6296149  
  211. Hruska KA, Ban D, Avioli LV. Renal tubular acidosis. Arch Intern Med. 1982;142(10):1909-13. PMID:7125772  
  212. Cohn DE, Hruska KA, Klahr S, Hammerman MR. Increased Na+-H+ exchange in brush border vesicles from dogs with renal failure. Am J Physiol. 1982;243(3):F293-9. PMID:7114259  
  213. Meltzer V, Weinreb S, Bellorin-Font E, Hruska KA. Parathyroid hormone stimulation of renal phosphoinositide metabolism is a cyclic nucleotide-independent effect. Biochim Biophys Acta. 1982;712(2):258-67. PMID:6289907  
  214. Weinreb S, Hruska KA, Klahr S, Hammerman MR. Uptake of Pi in brush border vesicles after release of unilateral ureteral obstruction. Am J Physiol. 1982;243(1):F29-35. PMID:7046473  
  215. Slatopolsky E, Martin K, Morrissey J, Hruska K. Current concepts of the metabolism and radioimmunoassay of parathyroid hormone. J Lab Clin Med. 1982;99(3):309-16. PMID:7057058  
  216. Cohen MA, Hruska KA, Daughaday WH. Free myo-inositol in canine kidneys: selective concentration in the renal medulla. Proc Soc Exp Biol Med. 1982;169(3):380-5. PMID:7063520  
  217. Hammerman MR, Hruska KA. Cyclic AMP-dependent protein phosphorylation in canine renal brush-border membrane vesicles is associated with decreased phosphate transport. J Biol Chem. 1982;257(2):992-9. PMID:6274874  
  218. Klahr S, Morrissey J, Hruska K. Effect of parathyroid hormone on phospholipid metabolism. Adv Exp Med Biol. 1982;151:561-75. PMID:6758524  
  219. Martin KJ, Hruska K, Tamayo J, Arbelaez M, Slatopolsky E. Hepatic metabolism of parathyroid hormone. Miner Electrolyte Metab. 1982;8(3-4):173-8. PMID:7167132  
  220. Martin K, Hruska K, Slatopolsky E. Interactions between liver and parathyroid hormone. Adv Exp Med Biol. 1982;151:597-605. PMID:7180665  
  221. Hruska KA, Klahr S, Hammerman MR. Decreased luminal membrane transport of phosphate in chronic renal failure. Am J Physiol. 1982;242(1):F17-22. PMID:7058889  
  222. Hruska KA, Hammerman MR. Parathyroid hormone inhibition of phosphate transport in renal brush border vesicles from phosphate-depleted dogs. Biochim Biophys Acta. 1981;645(2):351-6. PMID:7272293  
  223. Rosenbaum RW, Hruska KA, Korkor A, Anderson C, Slatopolsky E. Decreased phosphate reabsorption after renal transplantation: Evidence for a mechanism independent of calcium and parathyroid hormone. Kidney Int. 1981;19(4):568-78. PMID:6264200  
  224. Hruska KA, Korkor A, Martin K, Slatopolsky E. Peripheral metabolism of intact parathyroid hormone. Role of liver and kidney and the effect of chronic renal failure. J Clin Invest. 1981;67(3):885-92. PMCID:PMC370640  PMID:7204561  
  225. Slatopolsky E, Martin K, Morrissey J, Hruska, K. Current concepts of the metabolism and radioimmunoassay of parathyroid hormone. Semin Nephrol. 1981;1:319-334. 
  226. Hammerman MR, Karl IE, Hruska KA. Regulation of canine renal vesicle Pi transport by growth hormone and parathyroid hormone. Biochim Biophys Acta. 1980;603(2):322-35. PMID:7459358  
  227. Sicard GA, Anderson CB, Hruska KA, Martin KJ, Etheredge EE. Parathormone levels after subtotal and total (autotransplantation) parathyroidectomy for secondary hyperparathyroidism. J Surg Res. 1980;29(6):541-5. PMID:7431907  
  228. Galim EB, Hruska K, Bier DM, Matthews DE, Haymond MW. Branched-chain amino acid nitrogen transfer to alamine in vivo in dogs. Direct isotopic determination with [15N]leucine. J Clin Invest. 1980;66(6):1295-304. doi:10.1172/JCI109981  PMCID:PMC371614  PMID:7440716  
  229. Teitelbaum SL, Bergfeld MA, Freitag J, Hruska KA, Slatopolsky E. Do parathyroid hormone and 1,25-dithydroxyvitamin D modulate bone formation in uremia? J Clin Endocrinol Metab. 1980;51(2):247-51. doi:10.1210/jcem-51-2-247  PMID:6893204  
  230. Martin KJ, Hruska K, Freitag J, Bellorin-Font E, Klahr S, Slatopolsky E. The clinical utility of radioimmunoassays for parathyroid hormone. Min Electrol Metab. 1980;3:283. 
  231. Martin KJ, Hruska KA, Freitag JJ, Klahr S, Slatopolsky E. The peripheral metabolism of parathyroid hormone. N Engl J Med. 1979;301(20):1092-8. doi:10.1056/NEJM197911153012005  PMID:386126  
  232. Hruska KA, Blondin J, Bass R, Santiago J, Thomas L, Altsheler P, Martin K, Klahr S. Effect of intact parathyroid hormone on hepatic glucose release in the dog. J Clin Invest. 1979;64(4):1016-23. doi:10.1172/JCI109538  PMCID:PMC372211  PMID:479365  
  233. Rosenbaum RW, Hruska KA, Anderson C, Robson AM, Slatopolsky E, Klahr S. Inulin: an inadequate marker of glomerular filtration rate in kidney donors and transplant recipients? Kidney Int. 1979;16(2):179-86. PMID:390219  
  234. Peterson LJ, Hruska KA. The benefits of evaluation of the patient with recurrent or multiple calcium stones. J Urol. 1979;121(6):766-8. PMID:458948  
  235. Molitoris BA, Hruska KA, Fishman N, Daughaday WH. Effects of glucose and parathyroid hormone on the renal handling of myoinositol by isolated perfused dog kidneys. J Clin Invest. 1979;63(6):1110-8. doi:10.1172/JCI109403  PMCID:PMC372057  PMID:221533  
  236. Martin KJ, Freitag JJ, Conrades MB, Hruska KA, Klahr S, Slatopolsky E. Selective uptake of the synthetic amino terminal fragment of bovine parathyroid hormone by isolated perfused bone. J Clin Invest. 1978;62(2):256-61. doi:10.1172/JCI109124  PMCID:PMC371761  PMID:209059  
  237. Hruska, K.A., Teitelbaum, S.L., Kopelman, R., Richardson, C.A., Miller, P., Debman, J., Martin, K., Slatopolsky, E. The predictability of the histologic al features of uremic bone disease by non-invasive techniques. Metab Bone Dis & Rel Res. 1978;1:39-44. 
  238. Slatopolsky E, Rutherford WE, Hruska K, Martin K, Klahr S. How important is phosphate in the pathogenesis of renal osteodystrophy? Arch Intern Med. 1978;138 Spec No:848-52. PMID:646572  
  239. Slatopolsky E, Gray R, Adams ND, Lewis J, Hruska K, Martin K, Klahr S, DeLuca HF, Lehmann J. Low levels of 1,25(OH)2D3 are not responsible for the development of secondary hyperparathyroidism in early renal failure. Kid Int. 1978;14:S733. 
  240. Anderson CB, Haid SD, Hruska KA, Etheredge EA. Significance of microbial contamination of stored cadaver kidneys. Arch Surg. 1978;113(3):269-71. PMID:25059  
  241. Freitag J, Martin KJ, Hruska KA, Anderson C, Conrades M, Ladenson J, Klahr S, Slatopolsky E. Impaired parathyroid hormone metabolism in patients with chronic renal failure. N Engl J Med. 1978;298(1):29-32. doi:10.1056/NEJM197801052980107  PMID:337145  
  242. Martin KJ, Freitag JJ, Conrades MB, Hruska K, Klahr S, Slatopolsky E. The uptake of parathyroid hormone by isolated perfused bone: possible significance of peripheral hormone metabolism. Trans Assoc Am Physicians. 1978;91:358-67. PMID:224552  
  243. Anderson CB, Haid SD, Hruska KA, Etheredge EE. Renal injury by companion kidney during hypothermic pulsatile perfusion. Surgery. 1978;83(1):72-7. PMID:619474  
  244. Teitelbaum SL, Hruska KA, Shieber W, Debnam JW, Nichols SH. Tetracycline fluorescence in uremic and primary hyperparathyroid bone. Kidney Int. 1977;12(5):366-72. PMID:604625  
  245. Martin KJ, Hruska KA, Lewis J, Anderson C, Slatopolsky E. The renal handling of parathyroid hormone. Role of peritubular uptake and glomerular filtration. J Clin Invest. 1977;60(4):808-14. doi:10.1172/JCI108834  PMCID:PMC372428  PMID:893678  
  246. Hruska KA, Martin K, Mennes P, Greenwalt A, Anderson C, Klahr S, Slatopolsky E. Degradation of parathyroid hormone and fragment production by the isolated perfused dog kidney. The effect of glomerular filtration rate and perfusate CA++ concentrations. J Clin Invest. 1977;60(3):501-10. doi:10.1172/JCI108802  PMCID:PMC372395  PMID:893661  
  247. Anderson CB, Haid SD, Hruska KA, Etheredge EE. Adverse effect of ischemic companion kidney during ex vivo renal perfusion. Transplant Proc. 1977;9(3):1625-7. PMID:331601  
  248. Rutherford WE, Bordier P, Marie P, Hruska K, Harter H, Greenwalt A, Blondin J, Haddad J, Bricker N, Slatopolsky E. Phosphate control and 25-hydroxycholecalciferol administration in preventing experimental renal osteodystrophy in the dog. J Clin Invest. 1977;60(2):332-41. doi:10.1172/JCI108781  PMCID:PMC372373  PMID:874095  
  249. Martin K, Hruska K, Greenwalt A, Klahr S, Slatopolsky E. Selective uptake of intact parathyroid hormone by the liver: differences between hepatic and renal uptake. J Clin Invest. 1976;58(4):781-8. doi:10.1172/JCI108529  PMCID:PMC333239  PMID:965485  
  250. Rutherford WE, Blondin J, Hruska K, Kopelman R, Klahr S, Slatopolsky E. Effect of 25-hydroxycholecalciferol on calcium absorption in chronic renal disease. Kidney Int. 1975;8(5):320-4. PMID:1195563  
  251. Hruska KA, Kopelman R, Rutherford WE, Klahr S, Slatopolsky E, Greenwalt A, Bascom T, Markham J. Metabolism in immunoreactive parathyroid hormone in the dog. The role of the kidney and the effects of chronic renal disease. J Clin Invest. 1975;56(1):39-48. doi:10.1172/JCI108077  PMCID:PMC436553  PMID:1141439  
  252. Hruska K, Kopelman R, Rutherford WE, Greenwalt A, Klahr S, Slatopolsky E. Parathyroid hormone (PTH) metabolism in chronic renal disease (CRD). Proc Eur Dial Transplant Assoc. 1975;11:457-64. PMID:1197270  
  253. Rutherford WE, Hruska K, Blondin J, Holick M, DeLuca H, Klahr S, Slatopolsky E. The effect of 5,6-trans vitamin D3 on calcium absorption in chronic renal disease. J Clin Endocrinol Metab. 1975;40(1):13-18. doi:10.1210/jcem-40-1-13  PMID:1112871  
  254. Rutherford E, Mercado A, Hruska KA, Harter H, Mason N, Sparks R, Klahr S, Slatopolsky E. An evaluation of a new and effective phosphate binding agent. Trans ASAIO. 1973;XIX. 
  255. Stein PD, Folkens AT, Hruska KA. Saccharomyces fungemia. Chest. 1970;58(2):173-5. PMID:5455300  
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