Mark J. Manary, M.D.  manary@kids.wustl.edu

Professor of Pediatrics, Emergency Medicine
Patient Oriented Research UnitEmergency Medicine

phone: (314) 454-2341

Education

  • B.S., Massachusetts Institute of Technology1977
  • M.D., Washington University School of Medicine1982

Training

  • Internship and Residency, St. Louis Children's Hospital1982 - 1985

Licensure and Board Certification

  • MO, Medical License1984
  • American Board of Pediatrics1988
  • Pediatric Advanced Life Support1989
  • Pediatric Advanced Life Support - Affiliate Faculty1989
  • Sexual Assault Forensic Examination (S.A.F.E.) - Provider1989
  • American Board of Pediatrics, Subspecialty Pediatric Emergency Medicine1994

Honors

  • CIBA Award of Community Service1980
  • St. Louis Pediatric Society Award1982
  • Fulbright Scholar1994 - 1995
  • Academic Humanitarian Physician of the Year, American Association of Medical Colleges2004
  • AOA Member, Washington University Chapter2005
  • Outstanding Graduate Student Mentor Award, Washington University Graduate Student Senate2006
  • Excellence in Pediatrics Award, St. Louis Pediatric Society2007
  • Rose Award for Community Education, St. Louis County Public Schools2007
  • Washington University Distinguished Alumni Faculty Award2007
  • Distinuished Community Service Award, Washington University in St. Louis School of Medicine2012
  • Named as a WHO Expert Advisory on the Management of Malnutrition in Children2012

Recent Publications view all (141)


Publication Co-Authors

  1. Owino V, Ahmed T, Freemark M, Kelly P, Loy A, Manary M, Loechl C. Environmental Enteric Dysfunction and Growth Failure/Stunting in Global Child Health. Pediatrics. 2016;138(6). PMCID:Pii: e20160641  
  2. Ordiz MI, Shaikh N, Trehan I, Maleta K, Stauber J, Shulman R, Devaraj S, Tarr PI, Manary MJ.. Environmental Enteric Dysfunction is Associated With Poor Linear Growth and Can Be Identified by Host Fecal mRNAs. J Pediatr Gastroenterol Nutr. 2016;63(5):453-459. PMID:27347722  
  3. Papathakis PC, Singh LN, Manary MJ. How Maternal Malnutrition Affects Linear Growth and Development in the Offspring. Mol Cell Endocrinol. 2016;435:40-47. PMID:26820126  
  4. Di Giovanni V, Bourdon C, Wang DX, Seshadri S, Senga E, Versloot CJ, Voskuijl W, Semba RD, Trehan I, Moaddel R, Ordiz MI, Zhang L, Parkinson J, Manary MJ, Bandsma RH. Metabolomic Changes in Serum of Children with Different Clinical Diagnoses of Malnutrition J Nutr. 2016. PMID:27807038  
  5. Semba RD, Trehan I, Gonzalez-Freire M, Kraemer K, Moaddel R, Ordiz MI, Ferrucci L, Manary MJ. Perspective: The Potential Role of Essential Amino Acids and the Mechanistic Target of Rapamycin Complex 1 (mTORCI) Pathway in the Pathogenesis of Child Stunting Adv Nutr. 2016;7(5):853-865. PMID:27633102  
  6. Trehan I, Goldbach HS, LaGrone LN, Meuli GJ, Wang RJ, Maleta KM, Manary MJ. Antibiotics As Part of the Management of Severe Acute Malnutrition. Malawi Med J. 2016;28(3):123-130. 
  7. Trehan I, Schechtman KB, Manary MJ. Amoxicillin for Severe Acute Malnutrition in Children. N Engl J Med. 2016;275(2):191. 
  8. Semba RD, Gonzalez-Freire M, Moaddel R, Trehan I, Maleta KM, Khadeer M, Ordiz MI, Ferrucci L, Manary MJ. Environmental Enteric Dysfunction is Associated with Altered Bile Acid Metabolism. J Pediatr Gastroenterol Nutr. 2016;104(1):191-197. PMID:27322559  
  9. Semba RD, Zhang P, Gonzalez-Freire M, Moaddel R, Trehan I, Maleta KM, Ordiz MI, Ferrucci L, Manary MJ. The Association of Serum Choline With Linear Growth Failure in Young Children From Rural Malawi. Am J Clin Nutr. 2016;104(1):191-197. PMID:27281303  
  10. Trehan I, Manary MJ. An Important Chapter in the Infection-Malnutrition Story Lancet Glob Health. 2016;4(7):e430-e431. PMID:27289200  
  11. Semba RD, Shardell M, Trehan I, Moaddel R, Maleta KM, Ordiz MI, Kraemer K, Khadeer M, Ferrucci L, Manary MJ. Metabolic Alterations in Children With Environmental Enteric Dysfunction. Sci Rep. 2016;6:28009. PMCID:PMC4904796  PMID:27294788  
  12. Stauber J, Shaikh N, Ordiz MI, Tarr PI, Manary MJ. Droplet digital PCR Quantifies Host Inflammatory Transcripts in Feces Reliably and Reproducibly Cell Immunol. 2016;303:43-49. PMID:27063479  
  13. Semba RD, Shardell M, Sakr Ashour FA, Moaddel R, Trehan I, Maleta KM, Ordiz MI, Kraemer K, Khadeer MA, Ferrucci L, Manary MJ. Child Stunting is Associated with Low Circulating Essential Amino Acids. EBioMedicine. 2016;6:246-452. PMCID:PMC4856740  PMID:27211567  
  14. Manary M, Callaghan M, Singh L, Briend A. Protein Quality and Growth in Malnourished Children Food Nutr Bull. 2016;37 Suppl 1:S29-S36. PMID:26857118  
  15. Stobaugh HC, Ryan KN, Kennedy JA, Grise JB, Crocker AH, Thakwalakwa C, Litkowski PE, Maleta KM, Manary MJ, Trehan I. Including Whey Protein and Whey Permeate in Ready-To-Use Supplementary Food Improves Recovery Rates in Children With Moderate Acute Malnutrition: A Randomized, Double-Blind Clinical Trial. Am J Clin Nutr. 2016;103(3):926-933. doi:10.3945/ajcn.115.124636  PMID:26864368  
  16. Trehan I, Kelly P, Shaikh N, Manary MJ. New Insights Into Environmental Enteric Dysfunction. Arch Dis Child. 2016;101(8):741-744. PMID:26933151  
  17. Blanton LV, Charbonneau MR, Salih T, Barratt MJ, Venkatesh S, Ilkaveya O, Subramanian S, Manary MJ, Trehan I, Jorgensen JM, Fan YM, Henrissat B, Leyn SA, Rodionov DA, Osterman AL, Maleta KM, Newgard CB, Ashorn P, Dewey KG, Gordon JI. Gut Bacteria That Prevent Growth Impairments Transmitted by Microbiota from Malnourished Children. Science. 2016;351(6275). PMCID:PMC4787260  PMID:26912898  
  18. Manary M, Callaghan M, Singh L, Briend A. Protein Quality and Growth in Malnourished Children. Food Nutr Bull. 2016. doi:10.1177/0379572116629023  PMID:26857118  
  19. Yu J, Ordiz MI, Stauber J, Shaikh N, Trehan I, Barnell E, Head RD, Maleta K, Tarr PI, Manary MJ. Environmental Enteric Dysfunction Includes a Broad Spectrum of Inflammatory Responses and Epithelial Repair Processes. Cell Mol Gastroenterol Hepatol. 2016;2(2):158-174.e1. doi:10.1016/j.jcmgh.2015.12.002  PMCID:PMC4769221  PMID:26973864  
  20. Weber JM, Ryan KN, Tandon R, Mathur M, Girma T, Steiner-Asiedu M, Saalia F, Zaidi S, Soofi S, Okos M, Vosti SA, Manary MJ. Acceptability of locally produced ready-to-use therapeutic foods in Ethiopia, Ghana, Pakistan and India. Matern Child Nutr. 2016. doi:10.1111/mcn.12250  PMID:26776270  
  21. Moodley-Govender E, Mulol H, Stauber J, Manary M, Coutsoudis A. Increased Exclusivity of Breastfeeding Associated with Reduced Gut Inflammation in Infants. Breastfeed Med. 2015;10:488-492. doi:10.1089/bfm.2015.0110  PMID:26594906  
  22. Trehan I, Benzoni NS, Wang AZ, Bollinger LB, Ngoma TN, Chimimba UK, Stephenson KB, Agapova SE, Maleta KM, Manary MJ. Common beans and cowpeas as complementary foods to reduce environmental enteric dysfunction and stunting in Malawian children: study protocol for two randomized controlled trials. Trials. 2015;16(1):520. doi:10.1186/s13063-015-1027-0  PMCID:PMC4650393  PMID:26578308  
  23. Maust A, Koroma AS, Abla C, Molokwu N, Ryan KN, Singh L, Manary MJ. Severe and Moderate Acute Malnutrition Can Be Successfully Managed with an Integrated Protocol in Sierra Leone. J Nutr. 2015;145(11):2604-2609. doi:10.3945/jn.115.214957  PMID:26423737  
  24. Reyes A, Blanton LV, Cao S, Zhao G, Manary M, Trehan I, Smith MI, Wang D, Virgin HW, Rohwer F, Gordon JI. Gut DNA viromes of Malawian twins discordant for severe acute malnutrition. Proc Natl Acad Sci U S A. 2015;112(38):11941-11946. doi:10.1073/pnas.1514285112  PMCID:PMC4586842  PMID:26351661  
  25. Ordiz MI, May TD, Mihindukulasuriya K, Martin J, Crowley J, Tarr PI, Ryan K, Mortimer E, Gopalsamy G, Maleta K, Mitreva M, Young G, Manary MJ. The effect of dietary resistant starch type 2 on the microbiota and markers of gut inflammation in rural Malawi children. Microbiome. 2015;3:37. doi:10.1186/s40168-015-0102-9  PMCID:PMC4558878  PMID:26334878  
  26. Ordiz MI, Ryan KN, Cimo ED, Stoner ME, Loehnig ME, Manary MJ. Effect of emulsifier and viscosity on oil separation in ready-to-use therapeutic food. Int J Food Sci Nutr. 2015;66(6):642-648. doi:10.3109/09637486.2015.1077784  PMID:26299733  
  27. Hsieh JC, Liu L, Zeilani M, Ickes S, Trehan I, Maleta K, Craig C, Thakwalakwa C, Singh L, Brenna JT, Manary MJ. High-Oleic Ready-to-Use Therapeutic Food Maintains Docosahexaenoic Acid Status in Severe Malnutrition. J Pediatr Gastroenterol Nutr. 2015;61(1):138-143. doi:10.1097/MPG.0000000000000741  PMCID:PMC4483140  PMID:25633498  
  28. Benzoni N, Korpe P, Thakwalakwa C, Maleta K, Stephenson K, Manary M, Manary M. Plasma Endotoxin Core Antibody Concentration and Linear Growth are Unrelated in Rural Malawian Children Aged 2-5 Years. BMC Res Notes. 2015;8:258. doi:10.1186/s13104-015-1238-1  PMCID:PMC4477295  PMID:26103960  
  29. Brenna JT, Akomo P, Bahwere P, Berkley JA, Calder PC, Jones KD, Liu L, Manary M, Trehan I, Briend A. Balancing Omega-6 and Omega-3 Fatty Acids in Ready-To-Use Therapeutic Foods (RUTF). BMC Med. 2015;13:117. doi:10.1186/s12916-015-0352-1  PMCID:PMC4433071  PMID:25980919  
  30. Anagnostou K. Recent advances in immunotherapy and vaccine development for peanut allergy. Ther Adv Vaccines. 2015;3(3):55-65. doi:10.1177/2051013615591739  PMCID:PMC4530404  PMID:26288733  
  31. Iannotti LL, Trehan I, Clitheroe KL, Manary MJ. Diagnosis and treatment of severely malnourished children with diarrhoea. J Paediatr Child Health. 2015;51(4):387-395. doi:10.1111/jpc.12711  PMID:25196813  
  32. May T, Westcott C, Thakwalakwa C, Ordiz MI, Maleta K, Westcott J, Ryan K, Hambidge KM, Miller LV, Young G, Mortimer E, Manary MJ, Krebs NF. Resistant starch does not affect zinc homeostasis in rural Malawian children. J Trace Elem Med Biol. 2015;30:43-48. doi:10.1016/j.jtemb.2015.01.005  PMID:25744509  
  33. Trehan I, Banerjee S, Murray E, Ryan KN, Thakwalakwa C, Maleta KM, Manary MJ. Extending supplementary feeding for children younger than 5 years with moderate acute malnutrition leads to lower relapse rates. J Pediatr Gastroenterol Nutr. 2015;60(4):544-549. doi:10.1097/MPG.0000000000000639  PMCID:PMC4380557  PMID:25419681  
  34. Briend A, Akomo P, Bahwere P, De Pee S, Dibari F, Golden MH, Manary M, Ryan K. Developing food supplements for moderately malnourished children: lessons learned from ready-to-use therapeutic foods. Food Nutr Bull. 2015;36(1 Suppl):S53-S58. PMID:25902615  
  35. Osendarp S, Rogers B, Ryan K, Manary M, Akomo P, Bahwere P, Belete H, Zeilani M, Islam M, Dibari F, De Pee S. Ready-to-use foods for management of moderate acute malnutrition: considerations for scaling up production and use in programs. Food Nutr Bull. 2015;36(1 Suppl):S59-S64. PMID:25902616  
  36. Murray E, Manary M. Possible role of the microbiome in the development of acute malnutrition and implications for food-based strategies to prevent and treat acute malnutrition. Food Nutr Bull. 2015;36(1 Suppl):S72-S75. PMID:25902618  
  37. Trehan I, Manary MJ. Management of severe acute malnutrition in low-income and middle-income countries. Arch Dis Child. 2015;100(3):283-287. doi:10.1136/archdischild-2014-306026  PMID:25421910  
  38. Kau AL, Planer JD, Liu J, Rao S, Yatsunenko T, Trehan I, Manary MJ, Liu TC, Stappenbeck TS, Maleta KM, Ashorn P, Dewey KG, Houpt ER, Hsieh CS, Gordon JI. Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy. Sci Transl Med. 2015;7(276):276ra24. doi:10.1126/scitranslmed.aaa4877  PMCID:PMC4423598  PMID:25717097  
  39. Smith HE, Ryan KN, Stephenson KB, Westcott C, Thakwalakwa C, Maleta K, Cheng JY, Brenna JT, Shulman RJ, Trehan I, Manary MJ. Multiple micronutrient supplementation transiently ameliorates environmental enteropathy in Malawian children aged 12-35 months in a randomized controlled clinical trial. J Nutr. 2014;144(12):2059-2065. doi:10.3945/jn.114.201673  PMID:25411039  
  40. Ryan KN, Adams KP, Vosti SA, Ordiz MI, Cimo ED, Manary MJ. A comprehensive linear programming tool to optimize formulations of ready-to-use therapeutic foods: an application to Ethiopia. Am J Clin Nutr. 2014;100(6):1551-1558. doi:10.3945/ajcn.114.090670  PMID:25411290  
  41. Murray E, Manary M. Home-based therapy for severe acute malnutrition with ready-to-use food. Paediatr Int Child Health. 2014;34(4):266-270. doi:10.1179/2046905514Y.0000000135  PMID:25066618  
  42. Young GP, Mortimer EK, Gopalsamy GL, Alpers DH, Binder HJ, Manary MJ, Ramakrishna BS, Brown IL, Brewer TG. Zinc deficiency in children with environmental enteropathy-development of new strategies: report from an expert workshop. Am J Clin Nutr. 2014;100(4):1198-1207. doi:10.3945/ajcn.113.075036  PMCID:PMC4163797  PMID:25240082  
  43. Ryan KN, Stephenson KB, Trehan I, Shulman RJ, Thakwalakwa C, Murray E, Maleta K, Manary MJ. Zinc or albendazole attenuates the progression of environmental enteropathy: a randomized controlled trial. Clin Gastroenterol Hepatol. 2014;12(9):1507-1513.e1. doi:10.1016/j.cgh.2014.01.024  PMID:24462483  
  44. Thakwalakwa C, Phiri A, Rollins N, Heikens GT, Barnell EK, Manary M. Growth and HIV-free survival of HIV-exposed infants in Malawi: a randomized trial of two complementary feeding interventions in the context of maternal antiretroviral therapy. J Acquir Immune Defic Syndr. 2014;66(2):181-187. doi:10.1097/QAI.0000000000000150  PMID:24662296  
  45. Mangani C, Cheung YB, Maleta K, Phuka J, Thakwalakwa C, Dewey K, Manary M, Puumalainen T, Ashorn P. Providing lipid-based nutrient supplements does not affect developmental milestones among Malawian children. Acta Paediatr. 2014;103(1):e17-26. doi:10.1111/apa.12443  PMID:24118040  
  46. Iannotti LL, Trehan I, Manary MJ. Review of the safety and efficacy of vitamin A supplementation in the treatment of children with severe acute malnutrition. Nutr J. 2013;12:125-139. doi:10.1186/1475-2891-12-125  PMCID:PMC3850897  PMID:24028603  
  47. Trehan I, Maleta KM, Manary MJ. Antibiotics for uncomplicated severe malnutrition. N Engl J Med. 2013;368(25):2436-2437. doi:10.1056/NEJMc1304407  PMID:23782188  
  48. Lim ES, Reyes A, Antonio M, Saha D, Ikumapayi UN, Adeyemi M, Stine OC, Skelton R, Brennan DC, Mkakosya RS, Manary MJ, Gordon JI, Wang D. Discovery of STL polyomavirus, a polyomavirus of ancestral recombinant origin that encodes a unique T antigen by alternative splicing. Virology. 2013;436(2):295-303. doi:10.1016/j.virol.2012.12.005  PMCID:PMC3693558  PMID:23276405  
  49. Chang CY, Trehan I, Wang RJ, Thakwalakwa C, Maleta K, Deitchler M, Manary MJ. Children successfully treated for moderate acute malnutrition remain at risk for malnutrition and death in the subsequent year after recovery. J Nutr. 2013;143(2):215-220. doi:10.3945/jn.112.168047  PMID:23256140  
  50. Smith MI, Yatsunenko T, Manary MJ, Trehan I, Mkakosya R, Cheng J, Kau AL, Rich SS, Concannon P, Mychaleckyj JC, Liu J, Houpt E, Li JV, Holmes E, Nicholson J, Knights D, Ursell LK, Knight R, Gordon JI. Gut microbiomes of Malawian twin pairs discordant for kwashiorkor. Science. 2013;339(6119):548-554. doi:10.1126/science.1229000  PMCID:PMC3667500  PMID:23363771  
  51. Trehan I, Goldbach HS, LaGrone LN, Meuli GJ, Wang RJ, Maleta KM, Manary MJ. Antibiotics as part of the management of severe acute malnutrition. N Engl J Med. 2013;368(5):425-435. doi:10.1056/NEJMoa1202851  PMCID:PMC3654668  PMID:23363496  
  52. Agapova S, Stephenson K, Manary M, Weisz A, Tarr PI, Mkakosya R, Maleta K, Shulman RJ, Manary M, Shaikh N. Detection of low-concentration host mRNA transcripts in Malawian children at risk for environmental enteropathy. J Pediatr Gastroenterol Nutr. 2013;56(1):66-71. doi:10.1097/MPG.0b013e31826a107a  PMID:22832511  
  53. Wang RJ, Trehan I, LaGrone LN, Weisz AJ, Thakwalakwa CM, Maleta KM, Manary MJ. Investigation of food acceptability and feeding practices for lipid nutrient supplements and blended flours used to treat moderate malnutrition. J Nutr Educ Behav. 2013;45(3):258-263. doi:10.1016/j.jneb.2012.08.001  PMCID:PMC3644177  PMID:23246175  
  54. Weisz AJ, Manary MJ, Stephenson K, Agapova S, Manary FG, Thakwalakwa C, Shulman RJ, Manary MJ. Abnormal gut integrity is associated with reduced linear growth in rural Malawian children. J Pediatr Gastroenterol Nutr. 2012;55(6):747-750. doi:10.1097/MPG.0b013e3182650a4d  PMID:22732897  
  55. Siebrasse EA, Reyes A, Lim ES, Zhao G, Mkakosya RS, Manary MJ, Gordon JI, Wang D. Identification of MW polyomavirus, a novel polyomavirus in human stool. J Virol. 2012;86(19):10321-10326. doi:10.1128/JVI.01210-12  PMCID:PMC3457274  PMID:22740408  
  56. Pond CD, Mant A, Bridges-Webb C, Purcell C, Eyland EA, Hewitt H, Saunders NA. Recognition of depression in the elderly: a comparison of general practitioner opinions and the Geriatric Depression Scale. J Agricultural Food Chemistry. 2012;60:3861-3866. PMID:2245889  
  57. Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, Contreras M, Magris M, Hidalgo G, Baldassano RN, Anokhin AP, Heath AC, Warner B, Reeder J, Kuczynski J, Caporaso JG, Lozupone CA, Lauber C, Clemente JC, Knights D, Knight R, Gordon JI. Human gut microbiome viewed across age and geography. Nature. 2012;486(7402):222-227. doi:10.1038/nature11053  PMCID:PMC3376388  PMID:22699611  
  58. Phuka JC, Gladstone M, Maleta K, Thakwalakwa C, Cheung YB, Briend A, Manary MJ, Ashorn P. Developmental outcomes among 18-month-old Malawians after a year of complementary feeding with lipid-based nutrient supplements or corn-soy flour. Matern Child Nutr. 2012;8(2):239-248. doi:10.1111/j.1740-8709.2011.00294.x  PMID:21342456  
  59. Kim MH, Cox C, Dave A, Draper HR, Kabue M, Schutze GE, Ahmed S, Kazembe PN, Kline MW, Manary M. Prompt initiation of ART With therapeutic food is associated with improved outcomes in HIV-infected Malawian children with malnutrition. J Acquir Immune Defic Syndr. 2012;59(2):173-176. doi:10.1097/QAI.0b013e3182405f8f  PMID:22107819  
  60. LaGrone LN, Trehan I, Meuli GJ, Wang RJ, Thakwalakwa C, Maleta K, Manary MJ. A novel fortified blended flour, corn-soy blend "plus-plus," is not inferior to lipid-based ready-to-use supplementary foods for the treatment of moderate acute malnutrition in Malawian children. Am J Clin Nutr. 2012;95(1):212-219. doi:10.3945/ajcn.111.022525  PMCID:PMC3238461  PMID:22170366  
  61. Phuka J, Ashorn U, Ashorn P, Zeilani M, Cheung YB, Dewey KG, Manary M, Maleta K. Acceptability of three novel lipid-based nutrient supplements among Malawian infants and their caregivers. Matern Child Nutr. 2011;7(4):368-377. doi:10.1111/j.1740-8709.2011.00297.x  PMID:21518250  
  62. Connor NE, Manary MJ, Maleta K. Monitoring the adequacy of catch-up growth among moderately malnourished children receiving home-based therapy using mid-upper arm circumference in southern Malawi. Matern Child Health J. 2011;15(7):980-984. doi:10.1007/s10995-010-0569-8  PMID:20082126  
  63. de Pee S, Manary M, Ashorn P. The Devil Is In the Details Nutr Rev. 2011;69(2):116-117. 
  64. Weisz A, Meuli G, Thakwalakwa C, Trehan I, Maleta K, Manary M. The duration of diarrhea and fever is associated with growth faltering in rural Malawian children aged 6-18 months. Nutr J. 2011;10(1):25-29. doi:10.1186/1475-2891-10-25  PMCID:PMC3068082  PMID:21418600  
  65. Sayre R, Beeching JR, Cahoon EB, Egesi C, Fauquet C, Fellman J, Fregene M, Gruissem W, Mallowa S, Manary M, Maziya-Dixon B, Mbanaso A, Schachtman DP, Siritunga D, Taylor N, Vanderschuren H, Zhang P. The BioCassava plus program: biofortification of cassava for sub-Saharan Africa. Annu Rev Plant Biol. 2011;62:251-272. doi:10.1146/annurev-arplant-042110-103751  PMID:21526968  
  66. Waterland RA, Kellermayer R, Laritsky E, Rayco-Solon P, Harris RA, Travisano M, Zhang W, Torskaya MS, Zhang J, Shen L, Manary MJ, Prentice AM. Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles. PLoS Genet. 2010;6(12):e1001252. doi:10.1371/journal.pgen.1001252  PMCID:PMC3009670  PMID:21203497  
  67. Oakley E, Reinking J, Sandige H, Trehan I, Kennedy G, Maleta K, Manary M. A ready-to-use therapeutic food containing 10% milk is less effective than one with 25% milk in the treatment of severely malnourished children. J Nutr. 2010;140(12):2248-2252. doi:10.3945/jn.110.123828  PMCID:PMC2981006  PMID:20980648  
  68. Kennedy G, Hambidge KM, Manary M. A reduced phytate diet does not reduce endogenous fecal zinc in children on a habitual high-phytate diet. J Pediatr Gastroenterol Nutr. 2010;51(5):678-679. doi:10.1097/MPG.0b013e3181e536f7  PMID:20818269  
  69. Trehan I, Amthor RE, Maleta K, Manary MJ. Evaluation of the routine use of amoxicillin as part of the home-based treatment of severe acute malnutrition. Trop Med Int Health. 2010;15(9):1022-1028. doi:10.1111/j.1365-3156.2010.02580.x  PMCID:PMC2962695  PMID:20545919  
  70. Manary MJ, Abrams SA, Griffin IJ, Quimper MM, Shulman RJ, Hamzo MG, Chen Z, Maleta K, Manary MJ. Perturbed zinc homeostasis in rural 3-5-y-old Malawian children is associated with abnormalities in intestinal permeability attributed to tropical enteropathy. Pediatr Res. 2010;67(6):671-675. doi:10.1203/PDR.0b013e3181da44dc  PMID:20496476  
  71. van Oosterhout JJ, Ndekha M, Moore E, Kumwenda JJ, Zijlstra EE, Manary M. The benefit of supplementary feeding for wasted Malawian adults initiating ART. AIDS Care. 2010;22(6):737-742. doi:10.1080/09540120903373581  PMID:20467944  
  72. Manary M, Ndekhat M, van Oosterhout JJ. Supplementary feeding in the care of the wasted HIV infected patient. Malawi Med J. 2010;22(2):46-48. PMCID:PMC3345755  PMID:21614881  
  73. Connor NE, Manary MJ, Maleta K. Monitoring the Adequacy of Catch-Up Growth Among Moderately Malnourished Children Receiving Home-Based Therapy Using Mid-Upper Arm Circumference in Southern Malawi Matern Child Health J. 2010. PMID:20422271  
  74. Gegios A, Amthor R, Maziya-Dixon B, Egesi C, Mallowa S, Nungo R, Gichuki S, Mbanaso A, Manary MJ. Children consuming cassava as a staple food are at risk for inadequate zinc, iron, and vitamin A intake. Plant Foods Hum Nutr. 2010;65(1):64-70. doi:10.1007/s11130-010-0157-5  PMCID:PMC2840668  PMID:20165984  
  75. Stephenson K, Amthor R, Mallowa S, Nungo R, Maziya-Dixon B, Gichuki S, Mbanaso A, Manary M. Consuming cassava as a staple food places children 2-5 years old at risk for inadequate protein intake, an observational study in Kenya and Nigeria. Nutr J. 2010;9:9. doi:10.1186/1475-2891-9-9  PMCID:PMC2837613  PMID:20187960  
  76. Lagrone L, Cole S, Schondelmeyer A, Maleta K, Manary MJ. Locally produced ready-to-use supplementary food is an effective treatment of moderate acute malnutrition in an operational setting. Ann Trop Paediatr. 2010;30(2):103-108. doi:10.1179/146532810X12703901870651  PMID:20522296  
  77. Trehan I, Shulman RJ, Ou CN, Maleta K, Manary MJ. A randomized, double-blind, placebo-controlled trial of rifaximin, a nonabsorbable antibiotic, in the treatment of tropical enteropathy. Am J Gastroenterol. 2009;104(9):2326-2333. doi:10.1038/ajg.2009.270  PMCID:PMC2758482  PMID:19491826  
  78. Manary MJ, Heikens GT, Golden M. Kwashiorkor: more hypothesis testing is needed to understand the aetiology of oedema. Malawi Med J. 2009;21(3):106-107. PMCID:PMC3717490  PMID:20345018  
  79. Ndekha MJ, van Oosterhout JJ, Zijlstra EE, Manary M, Saloojee H, Manary MJ. Supplementary feeding with either ready-to-use fortified spread or corn-soy blend in wasted adults starting antiretroviral therapy in Malawi: randomised, investigator blinded, controlled trial. BMJ. 2009;338:b1867. PMCID:PMC2685879  PMID:19465470  
  80. Matilsky DK, Maleta K, Castleman T, Manary MJ. Supplementary feeding with fortified spreads results in higher recovery rates than with a corn/soy blend in moderately wasted children. J Nutr. 2009;139(4):773-778. doi:10.3945/jn.108.104018  PMCID:PMC3151028  PMID:19225128  
  81. Amthor RE, Cole SM, Manary MJ. The use of home-based therapy with ready-to-use therapeutic food to treat malnutrition in a rural area during a food crisis. J Am Diet Assoc. 2009;109(3):464-467. doi:10.1016/j.jada.2008.11.028  PMID:19248863  
  82. Phuka JC, Maleta K, Thakwalakwa C, Cheung YB, Briend A, Manary MJ, Ashorn P. Postintervention growth of Malawian children who received 12-mo dietary complementation with a lipid-based nutrient supplement or maize-soy flour. Am J Clin Nutr. 2009;89(1):382-90. doi:10.3945/ajcn.2008.26483  PMID:19056572  
  83. Manary MJ, Sandige HL. Management of acute moderate and severe childhood malnutrition. BMJ. 2008;337:a2180. PMID:19008271  
  84. Phuka JC, Maleta K, Thakwalakwa C, Cheung YB, Briend A, Manary MJ, Ashorn P. Complementary feeding with fortified spread and incidence of severe stunting in 6- to 18-month-old rural Malawians. Arch Pediatr Adolesc Med. 2008;162(7):619-626. doi:10.1001/archpedi.162.7.619  PMCID:PMC3721756  PMID:18606932  
  85. Heikens GT, Bunn J, Amadi B, Manary M, Chhagan M, Berkley JA, Rollins N, Kelly P, Adamczick C, Maitland K, Tomkins A, Blantyre Working Group. Case management of HIV-infected severely malnourished children: challenges in the area of highest prevalence. Lancet. 2008;371(9620):1305-1307. doi:10.1016/S0140-6736(08)60565-6  PMID:18406865  
  86. Heikens GT, Amadi BC, Manary M, Rollins N, Tomkins A. Nutrition interventions need improved operational capacity. Lancet. 2008;371(9608):181-182. doi:10.1016/S0140-6736(07)61691-2  PMID:18207567  
  87. Flax VL, Ashorn U, Phuka J, Maleta K, Manary MJ, Ashorn P. Feeding patterns of underweight children in rural Malawi given supplementary fortified spread at home. Matern Child Nutr. 2008;4(1):65-73. doi:10.1111/j.1740-8709.2007.00098.x  PMID:18171408  
  88. Galpin L, Thakwalakwa C, Phuka J, Ashorn P, Maleta K, Wong WW, Manary MJ. Breast milk intake is not reduced more by the introduction of energy dense complementary food than by typical infant porridge. J Nutr. 2007;137(7):1828-1833. PMID:17585038  
  89. Linneman Z, Matilsky D, Ndekha M, Manary MJ, Maleta K, Manary MJ. A large-scale operational study of home-based therapy with ready-to-use therapeutic food in childhood malnutrition in Malawi. Matern Child Nutr. 2007;3(3):206-215. doi:10.1111/j.1740-8709.2007.00095.x  PMID:17539889  
  90. Lin CA, Boslaugh S, Ciliberto HM, Maleta K, Ashorn P, Briend A, Manary MJ. A prospective assessment of food and nutrient intake in a population of Malawian children at risk for kwashiorkor. J Pediatr Gastroenterol Nutr. 2007;44(4):487-493. doi:10.1097/MPG.0b013e31802c6e57  PMID:17414147  
  91. Kuusipalo H, Maleta K, Briend A, Manary M, Ashorn P. Growth and change in blood haemoglobin concentration among underweight Malawian infants receiving fortified spreads for 12 weeks: a preliminary trial. J Pediatr Gastroenterol Nutr. 2006;43(4):525-532. doi:10.1097/01.mpg.0000235981.26700.d3  PMID:17033530  
  92. Manary MJ. Local production and provision of ready-to-use therapeutic food (RUTF) spread for the treatment of severe childhood malnutrition. Food Nutr Bull. 2006;27(3 Suppl):S83-S89. PMID:17076214  
  93. Ciliberto MA, Manary MJ, Ndekha MJ, Briend A, Ashorn P. Home-based therapy for oedematous malnutrition with ready-to-use therapeutic food. Acta Paediatr. 2006;95(8):1012-1015. doi:10.1080/08035250600606803  PMID:16882579  
  94. Sullivan J, Ndekha M, Maker D, Hotz C, Manary MJ. The quality of the diet in Malawian children with kwashiorkor and marasmus. Matern Child Nutr. 2006;2(2):114-122. doi:10.1111/j.1740-8709.2006.00053.x  PMID:16881921  
  95. Manary MJ, Muglia LJ, Vogt SK, Yarasheski KE. Cortisol and its action on the glucocorticoid receptor in malnutrition and acute infection. Metabolism. 2006;55(4):550-554. doi:10.1016/j.metabol.2005.11.009  PMID:16546487  
  96. Patel MP, Sandige HL, Ndekha MJ, Briend A, Ashorn P, Manary MJ. Supplemental feeding with ready-to-use therapeutic food in Malawian children at risk of malnutrition. J Health Popul Nutr. 2005;23(4):351-357. PMID:16599106  
  97. Galpin L, Manary MJ, Fleming K, Ou CN, Ashorn P, Shulman RJ. Effect of Lactobacillus GG on intestinal integrity in Malawian children at risk of tropical enteropathy. Am J Clin Nutr. 2005;82(5):1040-1045. PMID:16280436  
  98. Ciliberto H, Ciliberto M, Briend A, Ashorn P, Bier D, Manary M. Antioxidant supplementation for the prevention of kwashiorkor in Malawian children: randomised, double blind, placebo controlled trial. BMJ. 2005;330(7500):1109-1112. doi:10.1136/bmj.38427.404259.8F  PMCID:PMC557886  PMID:15851401  
  99. Ciliberto MA, Sandige H, Ndekha MJ, Ashorn P, Briend A, Ciliberto HM, Manary MJ. Comparison of home-based therapy with ready-to-use therapeutic food with standard therapy in the treatment of malnourished Malawian children: a controlled, clinical effectiveness trial. Am J Clin Nutr. 2005;81(4):864-870. PMID:15817865  
  100. Ndekha MJ, Manary MJ, Ashorn P, Briend A. Home-based therapy with ready-to-use therapeutic food is of benefit to malnourished, HIV-infected Malawian children. Acta Paediatr. 2005;94(2):222-225. PMID:15981758  
  101. Sandige H, Ndekha MJ, Briend A, Ashorn P, Manary MJ. Home-based treatment of malnourished Malawian children with locally produced or imported ready-to-use food. J Pediatr Gastroenterol Nutr. 2004;39(2):141-146. PMID:15269617  
  102. Manary MJ, Yarasheski KE, Smith S, Abrams ET, Hart CA. Protein Quantity, Not Protein Quality, Accelerates Whole-Body Leucine Kinetics and the Acute Phase Response During Acute Infection in Marasmic Malawian Children Brit J Nutr. 2004;92:589-595. 
  103. Manary MJ, Yarasheski KE, Berger R, Abrams ET, Hart CA, Broadhead RL. Whole-body leucine kinetics and the acute phase response during acute infection in marasmic Malawian children. Pediatr Res. 2004;55(6):940-946. doi:10.1203/01.pdr.0000127017.44938.6d  PMID:15155863  
  104. Manary MJ, Ndkeha MJ, Ashorn P, Maleta K, Briend A. Home based therapy for severe malnutrition with ready-to-use food. Arch Dis Child. 2004;89(6):557-561. PMCID:PMC1719944  PMID:15155403  
  105. Maleta K, Kuittinen J, Duggan MB, Briend A, Manary M, Wales J, Kulmala T, Ashorn P. Supplementary feeding of underweight, stunted Malawian children with a ready-to-use food. J Pediatr Gastroenterol Nutr. 2004;38(2):152-158. PMID:14734876  
  106. Manary MJ, Yarasheski KE, Berger R, Broadhead RL. CO2 production during acute infection in malnourished Malawian children. Eur J Clin Nutr. 2004;58(1):116-120. doi:10.1038/sj.ejcn.1601757  PMID:14679376  
  107. Manary MJ, Yarasheski KE, Broadhead RL. Urea production and leucine oxidation in malnourished children with and without acute infection. Metabolism. 2002;51(11):1418-1422. PMID:12404191  
  108. Manary MJ, Hotz C, Krebs NF, Gibson RS, Westcott JE, Broadhead RL, Hambidge KM. Zinc homeostasis in Malawian children consuming a high-phytate, maize-based diet. Am J Clin Nutr. 2002;75(6):1057-1061. PMID:12036813  
  109. Manary MJ, Krebs NF, Gibson RS, Broadhead RL, Hambidge KM. Community-based dietary phytate reduction and its effect on iron status in Malawian children. Ann Trop Paediatr. 2002;22(2):133-136. doi:10.1179/027249302125000850  PMID:12070948  
  110. Manar MJ, MacPherson GD, Mcardle F, Jackson MJ, Hart CA. Selenium status, kwashiorkor and congestive heart failure. Acta Paediatr. 2001;90(8):950-952. PMID:11529549  
  111. Manary MJ, Hotz C, Krebs NF, Gibson RS, Westcott JE, Arnold T, Broadhead RL, Hambidge KM. Dietary phytate reduction improves zinc absorption in Malawian children recovering from tuberculosis but not in well children. J Nutr. 2000;130(12):2959-2964. PMID:11110854  
  112. Manary MJ, Leeuwenburgh C, Heinecke JW. Increased oxidative stress in kwashiorkor. J Pediatr. 2000;137(3):421-424. doi:10.1067/mpd.2000.107512  PMID:10969271  
  113. Manary MJ, Brewster DR. Intensive nursing care of kwashiorkor in Malawi. Acta Paediatr. 2000;89(2):203-207. PMID:10709892  
  114. Manary MJ, Yarasheski KE, Hart CA, Broadhead RL. Plasma urea appearance rate is lower when children with kwashiorkor and infection are fed egg white-tryptophan rather than milk protein. J Nutr. 2000;130(2):183-188. PMID:10720167  
  115. Mulholland EK, Ogunlesi OO, Adegbola RA, Weber M, Sam BE, Palmer A, Manary MJ, Secka O, Aidoo M, Hazlett D, Whittle H, Greenwood BM. Etiology of serious infections in young Gambian infants. Pediatr Infect Dis J. 1999;18(10 Suppl):S35-S41. PMID:10530572  
  116. The WHO Young Infants Study Group* (Manary MJ). Conclusions from the WHO multicenter study of serious infections in young infants. The WHO Young Infants Study Group. Pediatr Infect Dis J. 1999;18:S32-S34. PMID:10530571  
  117. The WHO young Infants Study Group* (Manary MJ). Bacterial etiology of serious infections in young infants in developing countries: results of a multicenter study. The WHO Young Infants Study Group. Pediatr Infect Dis J. 1999;18:S17-S22. PMID:10530569  
  118. The WHO Young Infants Study Group* (Manary MJ). Serious infections in young infants in developing countries: rationale for a multicenter study. The WHO Young Infants Study Group. Pediatr Infect Dis J. 1999;18:S4-S7. PMID:10530567  
  119. The WHO Young Infants Study Group* (Manary MJ). Methodology for a multicenter study of serious infections in young infants in developing countries. The WHO Young Infants Study Group. Pediatr Infect Dis J. 1999;18:S8-S16. PMID:10530568  
  120. The WHO Young Infants Study Group* (Manary MJ). Clinical prediction of serious bacterial infections in young infants in developing countries. The WHO Young Infants Study Group. Pediatr Infect Dis J. 1999;18:S23-S31. PMID:10530570  
  121. Manary MJ, Hart CA, Whyte MP. Severe hypophosphatemia in children with kwashiorkor is associated with increased mortality. J Pediatr. 1998;133(6):789-791. PMID:9842046  
  122. Brewster DR, Nanary MJ, Graham SM. Case Management of Kwashiorkor: An Intervention Project at 7-Nutrition Rehabilitation Centres n Malawi Malawi Medical Journal. 1998;11:15-20. 
  123. Brewster DR, Manary MJ, Menzies IS, Henry RL, O'Loughlin EV. Comparison of Milk and Maize Based Diets in Kwashiorkor Malawi Medical Journal. 1998;11:2-5. 
  124. Manary MJ, Broadhead RL, Yarasheski KE. Whole-body protein kinetics in marasmus and kwashiorkor during acute infection. Am J Clin Nutr. 1998;67:1205-1209. PMID:9625094  
  125. Manary MJ, Brewster DR. Potassium Supplementation in Kwashiorkor Malawi Medical Journal. 1998;11:6-10. 
  126. Manary MJ, Brewster DR, Broadhead RL, Graham SM, Hart CA, Crowley JR, Fjeld CR, Yarasheski KE. Whole-body protein kinetics in children with kwashiorkor and infection: a comparison of egg white and milk as dietary sources of protein. Am J Clin Nutr. 1997;66:643-648. PMID:9280187  
  127. Manary MJ, Brewster DR. Potassium supplementation in kwashiorkor. J Gastroenterol Nutr. 1997;24:194-201. PMID:9106107  
  128. Manary MJ, Brewster DR, Broadhead RL, Crowley JR, Fjeld CR, Yarasheski KE. Protein metabolism in children with edematous malnutrition and acute lower respiratory infection. Am J Clin Nutr. 1997;65(4):1005-1010. PMID:9094886  
  129. Brewster DR, Manary MJ, Graham SM. Case management of kwashiorkor: an intervention project at seven nutrition rehabilitation centres in Malawi. Eur J Clin Nutr. 1997;51(3):139-147. PMID:9076403  
  130. Brewster DR, Manary MJ, Menzies IS, O'Loughlin EV, Henry RL. Intestinal permeability in kwashiorkor. Arch Dis Child. 1997;76(3):236-241. PMCID:PMC1717121  PMID:9135265  
  131. Brewster DR, Manary MJ, Menzies IS, Henry RL, O'Loughlin EV. Comparison of milk and maize based diets in kwashiorkor. Arch Dis Child. 1997;76(3):242-248. PMCID:PMC1717098  PMID:9135266  
  132. Dowd MD, Krug S. Pediatric blunt cardiac injury: epidemiology, clinical features, and diagnosis. Pediatric Emergency Medicine Collaborative Research Committee: Working Group on Blunt Cardiac Injury. J Trauma. 1996;40(1):61-67. PMID:8577001  
  133. Dyke T, Lewis D, Heegaard W, Manary M, Flew S, Rudeen K. Predicting hypoxia in children with acute lower respiratory infection: a study in the highlands of Papua New Guinea. J Trop Pediatr. 1995;41(4):196-201. PMID:7563269  
  134. Brewster D, Manary MJ. Treatment of Severe Malnutrition Lanet. 1995;1995:453. 
  135. Dyke T, Manary M. Chest Infections in African Children. Clinical Signs Unreliable BMJ. 1993;306:1342. 
  136. Manary MJ, Hollifield WC. Childhood Sledding Injuries in 1990-1991 Pediatr Emerg Care. 1993;9:155-158. 
  137. Manary MJ, Lehmann D, Michael A, Coakley K, Taime J, Montgomery J, Granoff DM. Antigenuria in healthy Papua New Guinean children with nasal Haemophilus influenzae type b carriage. Ann Trop Paediatr. 1993;13(4):385-389. PMID:7506888  
  138. Manary MJ, Keating JP, Hirshberg GE. Quadriparesis due to potassium depletion. Crit Care Med. 1986;14(8):750-752. PMID:3720335  
  139. Darmaun D, Manary MJ, Matthews DE. A method for measuring both glutamine and glutamate levels and stable isotopic enrichments. Anal Biochem. 1985;147(1):92-102. PMID:4025827  
  140. Ordiz MI, Stephenson K, Agapova S, Wylie KM, Maleta K, Martin J, Trehan I, Tarr PI, Manary MJ. A Combined Intervention of Zinc, Multiple Micronutrients, and Albendazole Does Not Ameliorate Environmental Enteric Dysfunction or Stunting in Rural Malawian Children in a Double-Blind Randomized Controlled Trial. J Nutr. PMID:27807040  
  141. Ordiz MI, Stephenson K, Agapova S, Wylie KM, Maleta K, Martin J, Trehan I, Tarr PI, Manary MJ. Environmental Enteric Dysfunction and the Fecal Microbiota in Malawian Children. Am J Trop Med Hyg. 
Wash U School of Medicine
Children's Hospital St. Louis
Children's Discovery Institute
© 2017 by Washington University in St. Louis
One Brookings Drive, St. Louis, MO 63130