Rachel C. Orscheln, M.D.  orscheln_r@wustl.edu

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Associate Professor of Pediatrics, Infectious Diseases
Infectious Diseases

phone: (314) 454-6050

Clinical Interests

Dr. Orscheln is the director of ambulatory pediatric infectious diseases and the International Adoption Center at St. Louis Children’s Hospital. Her special clinical interests include adoption medicine, international health, antibiotic stewardship, and treatment of infections in immunocompromised hosts. Her current research interests include treatment of viral infections in normal and immunocompromised hosts.


  • BS, Honors Certificate, University of Missouri-Columbia1994
  • MD, Cum Laude , University of Missouri School of Medicine1998


  • Resident, St. Louis Children's Hospital1998 - 2001
  • Fellow, Washington University School of Medicine2001 - 2005

Licensure and Board Certification

  • 1998Pediatric Advanced Life Support
  • 1998Neonatal Advanced Life Support
  • 2001American Board of Pediatrics
  • 2001 - PresMO, Physician and Surgeon
  • 2005Pediatric Infectious Diseases

Honors and Awards

  • State of Missouri Bright Flight Scholarship1990 - 1994
  • University of Missouri Curators' Scholarship1990 - 1994
  • Honors Certificate for University of Missouri Honors College, Graduated Cum Laude from the University of Missouri- School of Medicine1994
  • Phi Beta Kappa1994
  • American Academy of Pediatrics Outstanding Resident Award2001
  • Best Doctors in St. Louis2015 - Pres
  • Washington University Unsung Hero Award2017
  • Lecturer of the Month2018

Recent Publications view all (18)

  1. X-linked Chronic Granulomatous Disease Presenting with Mediastinal Lipoblastoma and Adjacent Pneumonia. J Clin Immunol. 2021. PMID:34462840 
  2. Pilot Investigation of SARS-CoV-2 Secondary Transmission in Kindergarten Through Grade 12 Schools Implementing Mitigation Strategies - St. Louis County and City of Springfield, Missouri, December 2020. MMWR Morb Mortal Wkly Rep. 2021;70(12):449-455. PMCID:PMC7993558  PMID:33764961 
  3. Multicenter Interim Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2. J Pediatric Infect Dis Soc. 2021;10(1):34-48. PMCID:PMC7543452  PMID:32918548 
  4. Practical School Algorithms for Symptomatic or SARS-CoV-2-Exposed Students Are Essential for Returning Children to In-Person Learning. J Pediatr. 2021;229:275-277. PMCID:PMC7516575  PMID:32980377 
  5. SARS CoV-2 infection among patients using immunomodulatory therapies. Ann Rheum Dis. 2021;80(2):269-271. PMID:32759259 
  6. Initial Guidance on Use of Monoclonal Antibody Therapy for Treatment of COVID-19 in Children and Adolescents. J Pediatric Infect Dis Soc. 2021. PMCID:PMC7799019  PMID:33388760 
  7. Return to School for Pediatric Solid Organ Transplant Recipients in the United States During the COVID-19 Pandemic: Expert Opinion on Key Considerations and Best Practices. J Pediatric Infect Dis Soc. 2020. PMID:32750142 
  8. Multicenter initial guidance on use of antivirals for children with COVID-19/SARS-CoV-2. J Pediatric Infect Dis Soc. 2020. PMCID:PMC7188128  PMID:32318706 
  9. Longitudinal, strain-specific Staphylococcus aureus introduction and transmission events in households of children with community-associated meticillin-resistant S aureus skin and soft tissue infection: a prospective cohort study. Lancet Infect Dis. 2020;20(2):188-198. PMCID:PMC6995751  PMID:31784369 
  10. Skin and Soft Tissue Infection Treatment and Prevention Practices by Pediatric Infectious Diseases Providers. J Pediatric Infect Dis Soc. 2019. PMID:31773168 
  11. Bartonella henselae infection presenting as cervical spine osteomyelitis: case report. J Neurosurg Pediatr. 2018;22(2):189-194. PMID:29799351 
  12. Saksenaea vasiformis Orbital Cellulitis in an Immunocompetent Child Treated With Posaconazole. J Pediatric Infect Dis Soc. 2018. PMID:29522137 
  13. Daily chlorhexidine bathing to reduce bacteraemia in critically ill children: a multicentre, cluster-randomised, crossover trial. Lancet. 2013;381(9872):1099-106. doi:10.1016/S0140-6736(12)61687-0  PMID:23363666 
  14. contribution of genetically restricted, methicillin-susceptible strains to the ongoing epidemic of community-acquired Staphylococcus aureus infections. Clin Infect Dis. 2009;49(4):536-42. doi:10.1086/600881  PMCID:PMC2965061  PMID:19589082 
  15. Transmission of Panton-Valentine leukocidin-positive Staphylococcus aureus between patients with cystic fibrosis. J Pediatr. 2007;151(1):90-2. doi:10.1016/j.jpeds.2007.04.016  PMID:17586197 
  16. Panton-Valentine Leukocidin-positive methicillin-resistant Staphylococcus aureus lung infection in patients with cystic fibrosis. Chest. 2007;131(6):1718-25. doi:10.1378/chest.06-2756  PMID:17400676 
  17. Blinded comparison of repetitive-sequence PCR and multilocus sequence typing for genotyping methicillin-resistant Staphylococcus aureus isolates from a children's hospital in St. Louis, Missouri. J Clin Microbiol. 2006;44(6):2254-7. doi:10.1128/JCM.00690-06  PMCID:PMC1489435  PMID:16757633 
  18. Intrinsic reduced susceptibility of serotype 6 Streptococcus pyogenes to fluoroquinolone antibiotics. J Infect Dis. 2005;191(8):1272-9. doi:10.1086/428856  PMID:15776373 
Last updated: 10/26/2021
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