Luke-Pak-Silverman Lab

Investigating the role of serpins in maintaining cellular balance and understanding rare genetic disorders, our lab explores how disruptions in protease-serpin interactions contribute to disease. By studying mechanisms of cell stress, protease activity and serpin blockade, we aim to uncover pathways that lead to tissue damage and dysfunction. Our work includes modeling variants of uncertain significance through the Undiagnosed Diseases Network to advance diagnosis and therapeutic strategies for conditions such as alpha-1 antitrypsin deficiency and other serpinopathies.