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Nicole Brossier
nbrossier@wustl.edu
Resident, Residency
Hematology and Oncology
phone: (314) 454-6018
Education
BS,
University of Missouri-Rolla
,
2004
MD,
University of Alabama School of Medicine
,
2013
PhD,
University of Alabama-Birmingham
,
2011
Training
Pediatrics Residency, Washington University in St. Louis / St. Louis Children's Hospital
,
2013
-
2016
Pediatric Hematology/Oncology Fellow, Washington University in St. Louis / St. Louis Children's Hospital
,
2016
-
2019
Licensure and Board Certification
2017
-
Pres
MO, Medical License
2017
-
Pres
ABP Board Certified (General Pediatrics)
2021
-
Pres
Pediatric Hematology-Oncology
Honors and Awards
ASIP Trainee Travel Award to Experimental Biology 2008
,
2008
HCS Travel Award to Experimental Biology 2008
,
2008
ASIP Abraham D. Sobel Educational Fund Scholar Award 2009
,
2009
HCS Histochemist-in-Training Award 2009
,
2009
Alex's Lemonade Stand Young Investigator Award
,
2019
CTF First Time Conference Travel Award
,
2019
Hyundai Hope on Wheels Young Investigator Award
,
2020
K12 Child Health Research Center Development Award
,
2020
Francis Collins Scholar Award
,
2021
Recent Publications
view all (13)
Publication Co-Authors
David H. Gutmann, MD, PhD, FAAN
Amy Armstrong
Weber S++ and
Brossier NM
++, Prechtl AM, Barnes S, Wilson LS, Brosius SN, Longo JF, Carroll SL. .
R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in Neurofibromin-Null MPNST Cells. ++These two authors contributed equally to this work.
Cell Communication and Signaling
.
2021.
doi:
10.1186/s12964-021-00773-4
PMCID:
PMC8447793
PMID:
34530870
Brossier NM
++, Strahle JS++, Cler SJ, Wallendorf M, Gutmann DH.
Children with Supratentorial Midline Pilocytic Astrocytomas Exhibit Multiple Progressions and Acquisition of Neurologic Deficits over Time. ++These two authors contributed equally to this work.
Neuro-Oncology Advances
.
2021.
doi:
https://doi.org/10.1093/noajnl/vdab187
PMCID:
PMC8757579
PMID:
35036914
Brossier NM
, Thondapu S, Cobb OM, Dahiya S, Gutmann DH.
Temporal, spatial, and genetic constraints contribute to the patterning and penetrance of murine Neurofibromatosis-1 optic glioma.
Neuro Oncol
.
2021;23
(4):
625-637.
doi:
10.1093/neuonc/noaa237
PMCID:
PMC8041339
PMID:
33080011
Armstrong AE,
Brossier NM
, Hirbe AC.
Neurofibromatosis type 1-related tumours in paediatrics: an evolving treatment landscape.
Lancet Child Adolesc Health
.
2020;4
(7):
488-490.
PMID:
32562630
Brossier NM
, Prechtl AM, Longo JF, Barnes S, Wilson LS, Byer SJ, Brosius SN, Carroll SL.
Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells.
J Neuropathol Exp Neurol
.
2015;74
(6):
568-86.
PMCID:
PMC4433624
PMID:
25946318
Brossier NM
, Gutmann DH.
Improving outcomes for neurofibromatosis 1-associated brain tumors.
Expert Rev Anticancer Ther
.
2015;15
(4):
415-23.
PMID:
25652347
Brosius SN, Turk AN, Byer SJ,
Brossier NM
, Kohli L, Whitmire A, Mikhail FM, Roth KA, Carroll SL.
Neuregulin-1 overexpression and Trp53 haploinsufficiency cooperatively promote de novo malignant peripheral nerve sheath tumor pathogenesis.
Acta Neuropathol
.
2014;127
(4):
573-91.
PMCID:
PMC3999224
PMID:
24232507
Kohli L, Kaza N, Coric T, Byer SJ,
Brossier NM
, Klocke BJ, Bjornsti MA, Carroll SL, Roth KA.
4-Hydroxytamoxifen induces autophagic death through K-Ras degradation.
Cancer Res
.
2013;73
(14):
4395-405.
PMCID:
PMC3715566
PMID:
23722551
Byer SJ,
Brossier NM
, Peavler LT, Eckert JM, Watkins S, Roth KA, Carroll SL.
Malignant peripheral nerve sheath tumor invasion requires aberrantly expressed EGF receptors and is variably enhanced by multiple EGF family ligands.
J Neuropathol Exp Neurol
.
2013;72
(3):
219-33.
PMCID:
PMC3579504
PMID:
23399900
Kazmi SJ, Byer SJ, Eckert JM, Turk AN, Huijbregts RP,
Brossier NM
, Grizzle WE, Mikhail FM, Roth KA, Carroll SL.
Transgenic mice overexpressing neuregulin-1 model neurofibroma-malignant peripheral nerve sheath tumor progression and implicate specific chromosomal copy number variations in tumorigenesis.
Am J Pathol
.
2013;182
(3):
646-67.
PMCID:
PMC3586689
PMID:
23321323
Brossier NM
, Carroll SL.
Genetically engineered mouse models shed new light on the pathogenesis of neurofibromatosis type I-related neoplasms of the peripheral nervous system.
Brain Res Bull
.
2012;88
(1):
58-71.
PMCID:
PMC3263419
PMID:
21855613
Byer SJ, Eckert JM,
Brossier NM
, Clodfelder-Miller BJ, Turk AN, Carroll AJ, Kappes JC, Zinn KR, Prasain JK, Carroll SL.
Tamoxifen inhibits malignant peripheral nerve sheath tumor growth in an estrogen receptor-independent manner.
Neuro Oncol
.
2011;13
(1):
28-41.
PMCID:
PMC3018903
PMID:
21075781
Cantor E, Meyer A, Morris SM, Weisenberg JLZ,
Brossier NM
.
Dose-dependent seizure control with MEK inhibitor therapy for progressive glioma in a child with Neurofibromatosis Type 1
Child’s Nervous System
.
Last updated: 05/25/2022
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