Department of Pediatrics

Education

• BS, University of Missouri-Rolla, 2004
• MD, University of Alabama School of Medicine, 2013
• PhD, University of Alabama-Birmingham, 2011

Training

• Pediatrics Residency, Washington University in St. Louis / St. Louis Children's Hospital, 2013 - 2016
• Pediatric Hematology/Oncology Fellow, Washington University in St. Louis / St. Louis Children's Hospital, 2016 - 2019

Licensure and Board Certification

• 2017 - PresMO, Medical License
• 2017 - PresABP Board Certified (General Pediatrics)
• 2021 - PresPediatric Hematology-Oncology

Honors and Awards

• ASIP Trainee Travel Award to Experimental Biology 2008, 2008
• HCS Travel Award to Experimental Biology 2008, 2008
• ASIP Abraham D. Sobel Educational Fund Scholar Award 2009, 2009
• HCS Histochemist-in-Training Award 2009, 2009
• Alex's Lemonade Stand Young Investigator Award, 2019
• CTF First Time Conference Travel Award, 2019
• Hyundai Hope on Wheels Young Investigator Award, 2020
• K12 Child Health Research Center Development Award, 2020
• Francis Collins Scholar Award, 2021

Recent Publications view all (13)

Publication Co-Authors

David H. Gutmann, MD, PhD, FAAN

Amy Armstrong

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Nicole Brossier

1. Cantor E, Meyer A, Morris SM, Weisenberg JLZ, Brossier NM. Dose-dependent seizure control with MEK inhibitor therapy for progressive glioma in a child with Neurofibromatosis Type 1 Child’s Nervous System. 2022. doi:10.1007/s00381-022-05571-y.  PMID:35648241 
2. Weber S++ and Brossier NM++, Prechtl AM, Barnes S, Wilson LS, Brosius SN, Longo JF, Carroll SL. . R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in Neurofibromin-Null MPNST Cells. ++These two authors contributed equally to this work. Cell Communication and Signaling. 2021. doi:10.1186/s12964-021-00773-4  PMCID:PMC8447793  PMID:34530870 
3. Brossier NM++, Strahle JS++, Cler SJ, Wallendorf M, Gutmann DH. Children with Supratentorial Midline Pilocytic Astrocytomas Exhibit Multiple Progressions and Acquisition of Neurologic Deficits over Time. ++These two authors contributed equally to this work. Neuro-Oncology Advances. 2021. doi:https://doi.org/10.1093/noajnl/vdab187  PMCID:PMC8757579  PMID:35036914 
4. Brossier NM, Thondapu S, Cobb OM, Dahiya S, Gutmann DH. Temporal, spatial, and genetic constraints contribute to the patterning and penetrance of murine Neurofibromatosis-1 optic glioma. Neuro Oncol. 2021;23(4):625-637. doi:10.1093/neuonc/noaa237  PMCID:PMC8041339  PMID:33080011 
5. Armstrong AE, Brossier NM, Hirbe AC. Neurofibromatosis type 1-related tumours in paediatrics: an evolving treatment landscape. Lancet Child Adolesc Health. 2020;4(7):488-490. PMID:32562630 
6. Brossier NM, Prechtl AM, Longo JF, Barnes S, Wilson LS, Byer SJ, Brosius SN, Carroll SL. Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells. J Neuropathol Exp Neurol. 2015;74(6):568-86. PMCID:PMC4433624  PMID:25946318 
7. Brossier NM, Gutmann DH. Improving outcomes for neurofibromatosis 1-associated brain tumors. Expert Rev Anticancer Ther. 2015;15(4):415-23. PMID:25652347 
8. Brosius SN, Turk AN, Byer SJ, Brossier NM, Kohli L, Whitmire A, Mikhail FM, Roth KA, Carroll SL. Neuregulin-1 overexpression and Trp53 haploinsufficiency cooperatively promote de novo malignant peripheral nerve sheath tumor pathogenesis. Acta Neuropathol. 2014;127(4):573-91. PMCID:PMC3999224  PMID:24232507 
9. Kohli L, Kaza N, Coric T, Byer SJ, Brossier NM, Klocke BJ, Bjornsti MA, Carroll SL, Roth KA. 4-Hydroxytamoxifen induces autophagic death through K-Ras degradation. Cancer Res. 2013;73(14):4395-405. PMCID:PMC3715566  PMID:23722551 
10. Byer SJ, Brossier NM, Peavler LT, Eckert JM, Watkins S, Roth KA, Carroll SL. Malignant peripheral nerve sheath tumor invasion requires aberrantly expressed EGF receptors and is variably enhanced by multiple EGF family ligands. J Neuropathol Exp Neurol. 2013;72(3):219-33. PMCID:PMC3579504  PMID:23399900 
11. Kazmi SJ, Byer SJ, Eckert JM, Turk AN, Huijbregts RP, Brossier NM, Grizzle WE, Mikhail FM, Roth KA, Carroll SL. Transgenic mice overexpressing neuregulin-1 model neurofibroma-malignant peripheral nerve sheath tumor progression and implicate specific chromosomal copy number variations in tumorigenesis. Am J Pathol. 2013;182(3):646-67. PMCID:PMC3586689  PMID:23321323 
12. Brossier NM, Carroll SL. Genetically engineered mouse models shed new light on the pathogenesis of neurofibromatosis type I-related neoplasms of the peripheral nervous system. Brain Res Bull. 2012;88(1):58-71. PMCID:PMC3263419  PMID:21855613 
13. Byer SJ, Eckert JM, Brossier NM, Clodfelder-Miller BJ, Turk AN, Carroll AJ, Kappes JC, Zinn KR, Prasain JK, Carroll SL. Tamoxifen inhibits malignant peripheral nerve sheath tumor growth in an estrogen receptor-independent manner. Neuro Oncol. 2011;13(1):28-41. PMCID:PMC3018903  PMID:21075781