Department of Pediatrics

Education

• BA, Washington University, 1973
• PhD, University of Pennsylvania, 1977
• MD, University of Miami, 1984

Training

• Staff Fellow in Biochemistry, National Institutes of Health, 1977 - 1980
• Staff Fellow in Pediatric Metabolism, National Institutes of Health, 1980 - 1981
• Senior Staff Fellow in Pediatric Metabolism, National Institutes of Health, 1981 - 1982
• Pediatric Intern in Pediatrics, St. Louis Children’s Hospital, 1984 - 1985
• Pediatric Resident in Pediatrics, St. Louis Children’s Hospital, 1985 - 1986
• Pediatric Fellow in Gastroenterology, St. Louis Children’s Hospital, 1986 - 1989

Licensure and Board Certification

• 1985National Board of Medical Examiners
• 1986 - PresDEA
• 1986 - PresMO Missouri State BNDD
• 1986 - PresMO Missouri State Medical License
• 1989 - 1995Pediatrics - ABP
• 1995 - PresPediatric Gastroenterology - ABP
• 2014 - PresThe American Board of Pediatrics (ABP) Maintenance of Certification (MOC)

Honors and Awards

• Omicron Delta Kappa, 1973
• AGA-Industry Scholar Award (declined), 1990
• FIRST Award, National Institutes of Health, 1990
• American Heart Association Established Investigator, 1992
• Mead Johnson Nutritionals Award from the American Institute of Nutrition (Renamed the American Society for Nutritional Sciences), 1996
• Courage for the Cure Award, National Pancreas Foundation, 2010
• Opponent, Thesis Defense, University of Lund Sweden, 2010
• Best Doctors in America, 2012 - Pres
• Carol Ann Craumer Endowed Chair for Pediatric Reseach, 2015 - 2017
• Fellow of the American Gastroenterological Association, 2015
• Best Doctors in St. Louis, 2018 - Pres
• Fellow, American Association for the Advancement of Science, 2018
• Harvey R. Colten Professor of Pediatric Science, 2018 - Pres
• AcademicKeys, Who's Who in Medicine Higher Education, 2019 - Pres
• NASPGHAN Shwachman Award,, 2020
• Collaborative Alliance of Pancreatic Education and Research (CAPER) Senior Mentor Achievement Award, 2021

Recent Publications view all (118)

Publication Co-Authors

David A. Rudnick, M.D., Ph.D.

Xunjun Xiao, Ph.D

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Mark E. Lowe, M.D., Ph.D.

1. Chinenye R Dike, Gretchen Cress, Douglas S Fishman, Tanja Gonska, Chee Y Ooi, Emily R Perito, David Troendle, Cynthia M Tsai, Mark E Lowe, Aliye Uc. Vascular Complications in Pediatric Pancreatitis: A Case Series J Pediatr Gastroenterol Nutr .. 2021;73(4):e94-e97. doi:DOI: 10.1097/MPG.0000000000003218  PMCID:PMCID: PMC8455425  PMID:PMID: 34224489 
2. Gravdal A, Xiao X, Cnop M, El Jellas K, Johansson S, Njølstad PR, Lowe ME, Johansson BB, Molven A, Fjeld K. The position of single-base deletions in the VNTR sequence of the carboxyl ester lipase (CEL) gene determines proteotoxicity. J Biol Chem. 2021;100661. PMID:33862081 
3. Khatua B, El-Kurdi B, Patel K, Rood C, Noel P, Crowell M, Yaron JR, Kostenko S, Guerra A, Faigel DO, Lowe M, Singh VP. Adipose saturation reduces lipotoxic systemic inflammation and explains the obesity paradox. Sci Adv. 2021;7(5). PMCID:PMC7846167  PMID:33514548 
4. Perito ER, Lowe ME, Schwarzenberg SJ. Predicting Severity in Acute Pancreatitis in Children: What Can a Quantitative Score Add to Clinical Judgement? J Pediatr Gastroenterol Nutr. 2020;71(4):419-420. PMID:32740540 
5. Cassidy BM, Zino S, Fjeld K, Molven A, Lowe ME, Xiao X. Single nucleotide polymorphisms in CEL-HYB1 increase risk for chronic pancreatitis through proteotoxic misfolding. Hum Mutat. 2020. PMID:32906201 
6. Abu-El-Haija M, Lowe M, Barth B, Bellin MD, Fishman DS, Freedman S, Gariepy C, Giefer MJ, Gonska T, Heyman MB, Himes R, Husain S, Lin TK, Liu Q, Mascarenhas MR, Maqbool A, McFerron B, Morinville V, Nathan J, Ooi CY, Perito E, Pohl JF, Schwarzenberg SJ, Shah U, Troendle D, Werlin S, Wilschanski M, Zimmerman B, Uc A. Pediatric chronic pancreatitis without prior acute or acute recurrent pancreatitis: A report from the INSPPIRE consortium. Pancreatology. 2020;20(4):781-784. PMCID:PMC7781353  PMID:32332002 
7. Dike CR, Zimmerman B, Zheng Y, Wilschanski M, Werlin SL, Troendle D, Shah U, Schwarzenberg SJ, Pohl J, Perito ER, Ooi CY, Nathan JD, Morinville VD, McFerron B, Mascarenhas M, Maqbool A, Liu Q, Lin TK, Husain SZ, Heyman MB, Gonska T, Giefer MJ, Gariepy CE, Fishman DS, Bellin M, Barth B, Abu-El-Haija M, Lowe ME, Uc A. Clinical and Practice Variations in Pediatric Acute Recurrent or Chronic Pancreatitis: Report From The Insppire Study. J Pediatr Gastroenterol Nutr. 2020;71(1):112-8. doi:10.1097/MPG.0000000000002661  PMCID:PMC7305964  PMID:32079978 
8. de Oliveira C, Khatua B, Noel P, Kostenko S, Bag A, Balakrishnan B, Patel KS, Guerra AA, Martinez MN, Trivedi S, McCullough AE, Lam-Himlin DM, Navina S, Faigel DO, Fukami N, Pannala R, Evans Phillips A, Papachristou GI, Kershaw EE, Lowe ME, Singh VP. Pancreatic triglyceride lipase mediates lipotoxic systemic inflammation. J Clin Invest. 2020;130(4):1931-47. doi:10.1172/JCI132767  PMCID:PMC7108918  PMID:31917686 
9. Perito ER, Palermo TM, Pohl JF, Mascarenhas M, Abu-El-Haija M, Barth B, Bellin MD, Fishman DS, Freedman S, Gariepy C, Giefer M, Gonska T, Heyman MB, Himes RW, Husain SZ, Lin T, Liu Q, Maqbool A, McFerron B, Morinville VD, Nathan JD, Ooi CY, Rhee S, Schwarzenberg SJ, Shah U, Troendle DM, Werlin S, Wilschanski M, Zheng Y, Zimmerman MB, Lowe M, Uc A. Factors Associated With Frequent Opioid Use in Children With Acute Recurrent and Chronic Pancreatitis. J Pediatr Gastroenterol Nutr. 2020;70(1):106-114. PMCID:PMC6934913  PMID:31567889 
10. Palermo TM, Murray C, Aalfs H, Abu-El-Haija M, Barth B, Bellin MD, Ellery K, Fishman DS, Gariepy CE, Giefer MJ, Goday P, Gonska T, Heyman MB, Husain SZ, Lin TK, Liu QY, Mascarenhas MR, Maqbool A, McFerron B, Morinville VD, Nathan JD, Ooi CY, Perito ER, Pohl JF, Schwarzenberg SJ, Sellers ZM, Serrano J, Shah U, Troendle D, Zheng Y, Yuan Y, Lowe M, Uc A, Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer.. Web-based cognitive-behavioral intervention for pain in pediatric acute recurrent and chronic pancreatitis: Protocol of a multicenter randomized controlled trial from the study of chronic pancreatitis, diabetes and pancreatic cancer (CPDPC). Contemp Clin Trials. 2020;88:105898. PMCID:PMC6952537  PMID:31756383 
11. Lowe ME, Andersen DK, Caprioli RM, Choudhary J, Cruz-Monserrate Z, Dasyam AK, Forsmark CE, Gorelick FS, Gray JW, Haupt M, Kelly KA, Olive KP, Plevritis SK, Rappaport N, Roth HR, Steen H, Swamidass SJ, Tirkes T, Uc A, Veselkov K, Whitcomb DC, Habtezion A. Precision Medicine in Pancreatic Disease-Knowledge Gaps and Research Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Pancreas. 2019;48(10):1250-1258. PMID:31688587 
12. Bellin MD, Lowe M, Zimmerman MB, Wilschanski M, Werlin S, Troendle DM, Shah U, Schwarzenberg SJ, Pohl JF, Perito E, Ooi CY, Nathan JD, Morinville VD, McFerron BA, Mascarenhas MR, Maqbool A, Liu Q, Lin TK, Husain SZ, Himes R, Heyman MB, Gonska T, Giefer MJ, Gariepy CE, Freedman SD, Fishman DS, Barth B, Abu-El-Haija M, Uc A. Diabetes Mellitus in Children with Acute Recurrent and Chronic Pancreatitis: Data From the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort. J Pediatr Gastroenterol Nutr. 2019;69(5):599-606. PMCID:PMC6834233  PMID:31651815 
13. Lin TK, Fishman DS, Giefer MJ, Liu QY, Troendle D, Werlin S, Lowe ME, Uc A. Functional Pancreatic Sphincter Dysfunction in Children: Recommendations for Diagnosis and Management. J Pediatr Gastroenterol Nutr. 2019. PMID:31567892 
14. Liu QY, Abu-El-Haija M, Husain SZ, Barth B, Bellin M, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes R, Lin TK, Maqbool A, Mascarenhas M, McFerron BA, Morinville VD, Nathan JD, Ooi CY, Perito ER, Pohl JF, Rhee S, Schwarzenberg SJ, Shah U, Troendle D, Werlin SL, Wilschanski M, Zimmerman MB, Lowe ME, Uc A. Risk Factors for Rapid Progression From Acute Recurrent to Chronic Pancreatitis in Children: Report From INSPPIRE. J Pediatr Gastroenterol Nutr. 2019;69(2):206-211. PMCID:PMC6699635  PMID:31136562 
15. Lasher D, Szabó A, Masamune A, Chen JM, Xiao X, Whitcomb DC, Barmada MM, Ewers M, Ruffert C, Paliwal S, Issarapu P, Bhaskar S, Mani KR, Chandak GR, Laumen H, Masson E, Kume K, Hamada S, Nakano E, Seltsam K, Bugert P, Müller T, Groneberg DA, Shimosegawa T, Rosendahl J, Férec C, Lowe ME, Witt H, Sahin-Tóth M. Protease-Sensitive Pancreatic Lipase Variants Are Associated With Early Onset Chronic Pancreatitis. Am J Gastroenterol. 2019;114(6):974-983. PMCID:PMC6624845  PMID:30789418 
16. Schwarzenberg SJ, Uc A, Zimmerman B, Wilschanski M, Wilcox CM, Whitcomb DC, Werlin SL, Troendle D, Tang G, Slivka A, Singh VK, Sherman S, Shah U, Sandhu BS, Romagnuolo J, Rhee S, Pohl JF, Perito ER, Ooi CY, Nathan JD, Muniraj T, Morinville VD, McFerron B, Mascarenhas M, Maqbool A, Liu Q, Lin TK, Lewis M, Husain SZ, Himes R, Heyman MB, Guda N, Gonska T, Giefer MJ, Gelrud A, Gariepy CE, Gardner TB, Freedman SD, Forsmark CE, Fishman DS, Cote GA, Conwell D, Brand RE, Bellin M, Barth B, Banks PA, Anderson MA, Amann ST, Alkaade S, Abu-El-Haija M, Abberbock JN, Lowe ME, Yadav D. Chronic Pancreatitis: Pediatric and Adult Cohorts Show Similarities in Disease Progress Despite Different Risk Factors. J Pediatr Gastroenterol Nutr. 2019;68(4):566-573. PMID:30897605 
17. Grover AS, Freeman AJ, Abu-El-Haija M, Eisses JF, Gardner TB, Liu QY, Lowe ME, Nathan JD, Palermo TM, Singh VK, Trout AT, Uc A, Husain SZ, Morinville VD. Updates in Pediatric Pancreatology: Proceedings of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Frontiers in Pediatric Pancreatology Symposium. J Pediatr Gastroenterol Nutr. 2019;68(2):e27-e33. PMID:30888340 
18. Abu-El-Haija M, Lowe ME. Pediatric Pancreatitis-Molecular Mechanisms and Management. Gastroenterol Clin North Am. 2018;47(4):741-753. PMID:30337030 
19. Nemeth BC, Pesei ZG, Hegyi E, Szucs A, Szentesi A, Hegyi P, Lowe ME, Sahin-Toth M. The common truncation variant in pancreatic lipase related protein 2 (PNLIPRP2) is expressed poorly and does not alter risk for chronic pancreatitis PLoS One. 2018;13(11):e0206869. PMCID:6226108  PMID:30408063 
20. Uc A, Perito ER, Pohl JF, Shah U, Abu-El-Haija M, Barth B, Bellin MD, Ellery KM, Fishman DS, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes RW, Husain SZ, Maqbool A, Mascarenhas MR, McFerron BA, Morinville VD, Lin TK, Liu QY, Nathan JD, Rhee SJ, Ooi CY, Sellers ZM, Schwarzenberg SJ, Serrano J, Troendle DM, Werlin SL, Wilschanski M, Zheng Y, Yuan Y, Lowe ME, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC).. INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort Study: Design and Rationale for INSPPIRE 2 From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer. Pancreas. 2018;47(10):1222-1228. PMCID:PMC6195325  PMID:30325861 
21. Lowe ME, Goodman MT, Coté GA, Glesby MJ, Haupt M, Schork NJ, Singh VK, Andersen DK, Pandol SJ, Uc A, Whitcomb DC. Accelerating the Drug Delivery Pipeline for Acute and Chronic Pancreatitis: Summary of the Working Group on Drug Development and Trials in Recurrent Acute Pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Pancreas. 2018;47(10):1193-1199. PMCID:PMC6195328  PMID:30325857 
22. Fisher WE, Cruz-Monserrate Z, McElhany AL, Lesinski GB, Hart PA, Ghosh R, Van Buren G, Fishman DS, Rinaudo JAS, Serrano J, Srivastava S, Mace T, Topazian M, Feng Z, Yadav D, Pandol SJ, Hughes SJ, Liu RY, Lu E, Orr R, Whitcomb DC, Abouhamze AS, Steen H, Sellers ZM, Troendle DM, Uc A, Lowe ME, Conwell DL, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC).. Standard Operating Procedures for Biospecimen Collection, Processing, and Storage: From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer. Pancreas. 2018;47(10):1213-1221. PMCID:PMC6197069  PMID:30325860 
23. El Jellas K, Johansson BB, Fjeld K, Antonopoulos A, Immervoll H, Choi MH, Hoem D, Lowe ME, Lombardo D, Njølstad PR, Dell A, Mas E, Haslam SM, Molven A. The mucinous domain of pancreatic carboxyl-ester lipase (CEL) contains core 1/core 2 O-glycans that can be modified by ABO blood group determinants. J Biol Chem. 2018;293(50):19476-91. PMCID:6302156  PMID:30315106 
24. Scheers I, Palermo JJ, Freedman S, Wilschanski M, Shah U, Abu-El-Haija M, Barth B, Fishman DS, Gariepy C, Giefer MJ, Heyman MB, Himes RW, Husain SZ, Lin TK, Liu Q, Lowe M, Mascarenhas M, Morinville V, Ooi CY, Perito ER, Piccoli DA, Pohl JF, Schwarzenberg SJ, Troendle D, Werlin S, Zimmerman B, Uc A, Gonska T.. Recommendations for Diagnosis and Management of Autoimmune Pancreatitis in Childhood: Consensus From INSPPIRE J Pediatr Gastroenterol Nutri. 2018;67(2):232-236. PMCID: 6059991  PMID:29746340 
25. Uc A, Zimmerman MB, Wilschanski M, Werlin SL, Troendle D, Shah U, Schwarzenberg SJ, Rhee S, Pohl JF, Perito ER, Palermo JJ, Ooi CY, Liu Q, Lin TK, Morinville VD, McFerron BA, Husain SZ, Himes R, Heyman MB, Gonska T, Giefer MJ, Gariepy CE, Freedman SD, Fishman DS, Bellin MD, Barth B, Abu-El-Haija M, Lowe ME. Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis. Pancreas. 2018. PMID:30059474 
26. Lin TK, Abu-El-Haija M, Nathan JD, Palermo JP, Barth B, Bellin M, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes R, Husain SZ, Liu Q, Maqbool A, Mascarenhas M, McFerron B, Morinville VD, Ooi CY, Perito E, Pohl JF, Rhee S, Schwarzenberg SJ, Shah U, Troendle D, Werlin SL, Wilschanski M, Zimmerman MB, Lowe ME, Uc A. Pancreas Divisum in Pediatric Acute Recurrent and Chronic Pancreatitis: Report From INSPPIRE. J Clin Gastroenterol. 2018. PMID:29864067 
27. Parniczky A, Abu-El-Haija M, Husain S, Lowe M, Oracz G, Sahin-Toth M, Szabo FK, Uc A, Wilschanski M, Witt H, Czako L, Grammatikopoulos T, Rasmussen IC, Sutton R, Hegyi P. EPC/HPSG evidence-based guidelines for the management of pediatric pancreatitis Pancreatology. 2018;18(2). doi:10.1016/j.pan.2018.01.001  PMID:29398347 
28. Scheers I, Palermo JJ, Freedman S4 Wilschanski M5 Shah U6 Abu-El-Haija M3 Barth B7 Fishman DS8 Gariepy C9 Giefer MJ, Heyman MB, Himes RW, Husain SZ, Lin TK, Liu Q, Lowe M, Mascarenhas M, Morinville V, Ooi CY, Perito ER, Piccoli DA, Pohl JF, Schwarzenberg SJ, Troendle D, Werlin S, Zimmerman B, Uc A, Gonska T.. Autoimmune Pancreatitis in Children: Characteristic Features, Diagnosis, and Management. Am J Gastroenterol. 2017;2(10):1604-1611. doi:10.1038/ajg.2017.85  PMCID: 5908471  PMID:28374818 
29. Giefer MJ, Lowe ME, Werlin SL, Zimmerman B, Wilschanski M, Troendle D, Schwarzenberg SJ, Pohl JF, Palermo J, Ooi CY, Morinville VD, Lin TK, Husain SZ, Himes R, Heyman MB, Gonska T, Gariepy CE, Freedman SD, Fishman DS, Bellin MD, Barth B, Abu-El-Haija M, Uc A. Early-Onset Acute Recurrent and Chronic Pancreatitis Is Associated with PRSS1 or CTRC Gene Mutations. J Pediatr. 2017;186:95-100. PMCID:PMC5506853  PMID:28502372 
30. Troendle DM, Fishman DS, Barth BA, Giefer MJ, Lin TK, Liu QY, Abu-El-Haija M, Bellin MD, Durie PR, Freedman SD, Gariepy C, Gonska T, Heyman MB, Himes R, Husain SZ, Kumar S, Lowe ME, Morinville VD, Ooi CY, Palermo J, Pohl JF, Schwarzenberg SJ, Werlin S, Wilschanski M, Zimmerman MB, Uc A. Therapeutic Endoscopic Retrograde Cholangiopancreatography in Pediatric Patients With Acute Recurrent and Chronic Pancreatitis: Data From the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) Study. Pancreas. 2017;46(6):764-769. PMCID:PMC5502745  PMID:28609364 
31. Oparaji JA, Rose F, Okafor D, Howard A, Turner RL, Orabi AI, Byersdorfer C, Mi Q, Ritchey K, Lowe ME, Husain SZ. Risk Factors for Asparaginase-associated Pancreatitis: A Systematic Review. J Clin Gastroenterol. 2017. PMID:28375864 
32. Gariepy CE, Heyman MB, Lowe ME, Pohl JF, Werlin SL, Wilschanski M, Barth B, Fishman DS, Freedman SD, Giefer MJ, Gonska T, Himes R, Husain SZ, Morinville VD, Ooi CY, Schwarzenberg SJ, Troendle DM, Yen E, Uc A. Causal Evaluation of Acute Recurrent and Chronic Pancreatitis in Children: Consensus From the INSPPIRE Group. J Pediatr Gastroenterol Nutr. 2017;64(1):95-103. PMCID:PMC5191966  PMID:27782962 
33. Uc A, Andersen DK, Bellin MD, Bruce JI, Drewes AM, Engelhardt JF, Forsmark CE, Lerch MM, Lowe ME, Neuschwander-Tetri BA, OʼKeefe SJ, Palermo TM, Pasricha P, Saluja AK, Singh VK, Szigethy EM, Whitcomb DC, Yadav D, Conwell DL. Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Pancreas. 2016;45(10):1365-1375. PMCID:PMC5117429  PMID:27748719 
34. Xiao X, Jones G, Sevilla WA, Stolz DB, Magee KE, Haughney M, Mukherjee A, Wang Y, Lowe ME. A Carboxyl Ester Lipase (CEL) Mutant Causes Chronic Pancreatitis by Forming Intracellular Aggregates That Activate Apoptosis. J Biol Chem. 2016;291(44):23224-23236. PMCID:PMC5087739  PMID:27650499 
35. Kumar S, Ooi CY, Werlin S, Abu-El-Haija M, Barth B, Bellin MD, Durie PR, Fishman DS, Freedman SD, Gariepy C, Giefer MJ, Gonska T, Heyman MB, Himes R, Husain SZ, Lin TK, Lowe ME, Morinville V, Palermo JJ, Pohl JF, Schwarzenberg SJ, Troendle D, Wilschanski M, Zimmerman MB, Uc A. Risk Factors Associated With Pediatric Acute Recurrent and Chronic Pancreatitis: Lessons From INSPPIRE. JAMA Pediatr. 2016;170(6):562-9. PMCID:PMC5317277  PMID:27064572 
36. Szabo FK, Hornung L, Oparaji JA, Alhosh R, Husain SZ, Liu QY, Palermo J, Lin TK, Nathan JD, Podberesky DJ, Lowe M, Fei L, Abu-El-Haija M. A prognostic tool to predict severe acute pancreatitis in pediatrics. Pancreatology. 2016;16(3):358-64. PMID:27051062 
37. Ting J, Wilson L, Schwarzenberg SJ, Himes R, Barth B, Bellin MD, Durie PR, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Husain SZ, Kumar S, Morinville VD, Lowe ME, Ooi CY, Pohl JF, Troendle D, Usatin D, Werlin SL, Wilschanski M, Heyman MB, Uc A. Direct Costs of Acute Recurrent and Chronic Pancreatitis in Children in the INSPPIRE Registry. J Pediatr Gastroenterol Nutr. 2016;62(3):443-9. PMCID:PMC4767646  PMID:26704866 
38. Eisses JF, Criscimanna A, Dionise ZR, Orabi AI, Javed TA, Sarwar S, Jin S, Zhou L, Singh S, Poddar M, Davis AW, Tosun AB, Ozolek JA, Lowe ME, Monga SP, Rohde GK, Esni F, Husain SZ. Valproic Acid Limits Pancreatic Recovery after Pancreatitis by Inhibiting Histone Deacetylases and Preventing Acinar Redifferentiation Programs. Am J Pathol. 2015;185(12):3304-15. PMCID:PMC4729237  PMID:26476347 
39. Xiao X, Lowe ME. The β5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 (PNLIPRP2). J Biol Chem. 2015;290(48):28847-56. PMCID:PMC4661400  PMID:26494624 
40. Szabó A, Xiao X, Haughney M, Spector A, Sahin-Tóth M, Lowe ME. A novel mutation in PNLIP causes pancreatic triglyceride lipase deficiency through protein misfolding. Biochim Biophys Acta. 2015;1852(7):1372-9. PMCID:PMC4645278  PMID:25862608 
41. Calabuig-Navarro V, Yamauchi J, Lee S, Zhang T, Liu YZ, Sadlek K, Coudriet GM, Piganelli JD, Jiang CL, Miller R, Lowe M, Harashima H, Dong HH. Forkhead Box O6 (FoxO6) Depletion Attenuates Hepatic Gluconeogenesis and Protects against Fat-induced Glucose Disorder in Mice. J Biol Chem. 2015;290(25):15581-94. PMCID:PMC4505471  PMID:25944898 
42. Loverdos I, Swan MC, Shekherdimian S, Al-Rasheed AA, Schneider R, Fish JS, Ngan BY, Adeli K, Lowe ME, Singh VP, Sevilla WM, Langer JC, Gonska T. A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition. J Pediatr Surg Case Rep. 2015;3(5):223-226. PMCID:PMC4864014  PMID:27182490 
43. Schwarzenberg SJ, Bellin M, Husain SZ, Ahuja M, Barth B, Davis H, Durie PR, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes R, Kumar S, Morinville VD, Lowe ME, Nuehring NE, Ooi CY, Pohl JF, Troendle D, Werlin SL, Wilschanski M, Yen E, Uc A. Pediatric chronic pancreatitis is associated with genetic risk factors and substantial disease burden. J Pediatr. 2015;166(4):890-896.e1. PMCID:PMC4380827  PMID:25556020 
44. Schwarzenberg SJ, Bellin M, Husain SZ, Ahuja M, Barth B, Davis H, Durie PR, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes R, Kumar S, Morinville VD, Lowe ME, Nuehring NE, Ooi CY, Pohl JF, Troendle D, Werlin SL, Wilschanski M, Yen E, Uc A. Pediatric chronic pancreatitis is associated with genetic risk factors and substantial disease burden J Pediatr. 2015;166(4):890-6 e1. PMID:25556020 
45. Morinville VD, Lowe ME, Ahuja M, Barth B, Bellin MD, Davis H, Durie PR, Finley B, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes R, Husain S, Kumar S, Ooi CY, Pohl JF, Schwarzenberg SJ, Troendle D, Werlin SL, Wilschanski M, Yen E, Uc A. Design and implementation of INSPPIRE. J Pediatr Gastroenterol Nutr. 2014;59(3):360-4. PMCID:PMC4141003  PMID:24824361 
46. Singhi AD, Pai RK, Kant JA, Bartholow TL, Zeh HJ, Lee KK, Wijkstrom M, Yadav D, Bottino R, Brand RE, Chennat JS, Lowe ME, Papachristou GI, Slivka A, Whitcomb DC, Humar A. The histopathology of PRSS1 hereditary pancreatitis. Am J Surg Pathol. 2014;38(3):346-53. PMCID:PMC4321743  PMID:24525505 
47. Srinath A, Wendel D, Bond G, Lowe M. Visual diagnosis: 12-year-old girl with constipation and rectal bleeding. Pediatr Rev. 2014;35(2):e11-4. PMID:24488834 
48. Bellin MD, Freeman ML, Gelrud A, Slivka A, Clavel A, Humar A, Schwarzenberg SJ, Lowe ME, Rickels MR, Whitcomb DC, Matthews JB, PancreasFest Recommendation Conference Participants., Amann S, Andersen DK, Anderson MA, Baillie J, Block G, Brand R, Chari S, Cook M, Cote GA, Dunn T, Frulloni L, Greer JB, Hollingsworth MA, Kim KM, Larson A, Lerch MM, Lin T, Muniraj T, Robertson RP, Sclair S, Singh S, Stopczynski R, Toledo FG, Wilcox CM, Windsor J, Yadav D. Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest. Pancreatology. 2014;14(1):27-35. PMCID:PMC4058640  PMID:24555976 
49. Xiao X, Ross LE, Sevilla WA, Wang Y, Lowe ME. Porcine pancreatic lipase related protein 2 has high triglyceride lipase activity in the absence of colipase. Biochim Biophys Acta. 2013;1831(9):1435-41. PMCID:PMC3742628  PMID:23770034 
50. Johnson K, Ross L, Miller R, Xiao X, Lowe ME. Pancreatic lipase-related protein 2 digests fats in human milk and formula in concert with gastric lipase and carboxyl ester lipase. Pediatr Res. 2013;74(2):127-32. PMCID:PMC3737390  PMID:23732775 
51. Rickels MR, Bellin M, Toledo FG, Robertson RP, Andersen DK, Chari ST, Brand R, Frulloni L, Anderson MA, Whitcomb DC, PancreasFest Recommendation Conference Participants.. Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis: recommendations from PancreasFest 2012. Pancreatology. 2013;13(4):336-42. PMCID:PMC3830751  PMID:23890130 
52. Ross LE, Xiao X, Lowe ME. Identification of amino acids in human colipase that mediate adsorption to lipid emulsions and mixed micelles. Biochim Biophys Acta. 2013;1831(6):1052-9. PMCID:PMC3642234  PMID:23470256 
53. Xiao X, Ferguson MR, Magee KE, Hale PD, Wang Y, Lowe ME. The Arg92Cys colipase polymorphism impairs function and secretion by increasing protein misfolding. J Lipid Res. 2013;54(2):514-21. PMCID:PMC3837459  PMID:23204298 
54. Morinville VD, Husain SZ, Bai H, Barth B, Alhosh R, Durie PR, Freedman SD, Himes R, Lowe ME, Pohl J, Werlin S, Wilschanski M, Uc A, INSPPIRE Group.. Definitions of pediatric pancreatitis and survey of present clinical practices. J Pediatr Gastroenterol Nutr. 2012;55(3):261-5. PMCID:PMC3626452  PMID:22357117 
55. Orabi AI, Luo Y, Ahmad MU, Shah AU, Mannan Z, Wang D, Sarwar S, Muili KA, Shugrue C, Kolodecik TR, Singh VP, Lowe ME, Thrower E, Chen J, Husain SZ. IP3 receptor type 2 deficiency is associated with a secretory defect in the pancreatic acinar cell and an accumulation of zymogen granules. PLoS One. 2012;7(11):e48465. PMCID:PMC3504040  PMID:23185258 
56. Xiao X, Mukherjee A, Ross LE, Lowe ME. Pancreatic lipase-related protein-2 (PLRP2) can contribute to dietary fat digestion in human newborns. J Biol Chem. 2011;286(30):26353-63. PMCID:PMC3143598  PMID:21652702 
57. Xiao X, Ross LE, Miller RA, Lowe ME. Kinetic properties of mouse pancreatic lipase-related protein-2 suggest the mouse may not model human fat digestion. J Lipid Res. 2011;52(5):982-90. PMCID:PMC3073462  PMID:21382969 
58. Bai HX, Lowe ME, Husain SZ. What have we learned about acute pancreatitis in children? J Pediatr Gastroenterol Nutr. 2011;52(3):262-70. PMCID:PMC3626416  PMID:21336157 
59. McGuire BM, Zupanets IA, Lowe ME, Xiao X, Syplyviy VA, Monteleone J, Gargosky S, Dickinson K, Martinez A, Mokhtarani M, Scharschmidt BF. Pharmacology and safety of glycerol phenylbutyrate in healthy adults and adults with cirrhosis. Hepatology. 2010;51(6):2077-85. PMCID:PMC3733097  PMID:20512995 
60. Morinville VD, Barmada MM, Lowe ME. Increasing incidence of acute pancreatitis at an American pediatric tertiary care center: is greater awareness among physicians responsible? Pancreas. 2010;39(1):5-8. PMID:19752770 
61. Miller R, D'Agostino D, Erlanson-Albertsson C, Lowe ME. Enterostatin deficiency increases serum cholesterol but does not influence growth and food intake in mice. Am J Physiol Endocrinol Metab. 2009;297(4):E856-65. PMCID:PMC2763786  PMID:19622781 
62. Alves BN, Leong J, Tamang DL, Elliott V, Edelnant J, Redelman D, Singer CA, Kuhn AR, Miller R, Lowe ME, Hudig D. Pancreatic lipase-related protein 2 (PLRP2) induction by IL-4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity. J Leukoc Biol. 2009;86(3):701-12. PMCID:PMC2735286  PMID:19451396 
63. Alves BN, Marshall K, Tamang DL, Leong J, Redelman D, Elliott V, Lowe ME, Hudig D. Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs). Cell Biochem Funct. 2009;27(5):296-308. PMCID:PMC2837949  PMID:19548271 
64. Bourbon-Freie A, Dub RE, Xiao X, Lowe ME. Trp-107 and trp-253 account for the increased steady state fluorescence that accompanies the conformational change in human pancreatic triglyceride lipase induced by tetrahydrolipstatin and bile salt. J Biol Chem. 2009;284(21):14157-64. PMCID:PMC2682864  PMID:19346257 
65. Alves B, Leong J, Tamang DL, Elliott V, Lowe M, Hudig D. Hydrolysis of tumor cell lipids after CTL-mediated death. Int Immunol. 2009;21(5):543-53. PMCID:PMC2733839  PMID:19325035 
66. Miller R, Lowe ME. Carboxyl ester lipase from either mother's milk or the pancreas is required for efficient dietary triglyceride digestion in suckling mice. J Nutr. 2008;138(5):927-30. PMCID:PMC3687517  PMID:18424603 
67. Kandula L, Lowe ME. Etiology and outcome of acute pancreatitis in infants and toddlers. J Pediatr. 2008;152(1):106-10, 110.e1. PMID:18154910 
68. Li X, Lindquist S, Lowe M, Noppa L, Hernell O. Bile salt-stimulated lipase and pancreatic lipase-related protein 2 are the dominating lipases in neonatal fat digestion in mice and rats. Pediatr Res. 2007;62(5):537-41. PMCID:PMC3488855  PMID:17805199 
69. Morinville VD, Lowe ME, Elinoff BD, Whitcomb DC. Hereditary pancreatitis amlodipine trial: a pilot study of a calcium-channel blocker in hereditary pancreatitis. Pancreas. 2007;35(4):308-12. PMID:18090235 
70. D'Silva S, Xiao X, Lowe ME. A polymorphism in the gene encoding procolipase produces a colipase, Arg92Cys, with decreased function against long-chain triglycerides. J Lipid Res. 2007;48(11):2478-84. PMCID:PMC3684974  PMID:17715423 
71. Kandula L, Khan S, Whitcomb DC, Lowe ME. Acute pancreatitis in association with Campylobacter jejuni-associated diarrhea in a 15-year-old with CFTR mutations: is there a link? JOP. 2006;7(5):482-5. PMID:16998246 
72. Freie AB, Ferrato F, Carrière F, Lowe ME. Val-407 and Ile-408 in the beta5'-loop of pancreatic lipase mediate lipase-colipase interactions in the presence of bile salt micelles. J Biol Chem. 2006;281(12):7793-800. PMCID:PMC3695395  PMID:16431912 
73. Momsen WE, Mizuno NK, Lowe ME, Brockman HL. Real-time measurement of solute partitioning to lipid monolayers. Anal Biochem. 2005;346(1):139-49. PMID:16188221 
74. Moulton DE, Crandall W, Lakhani R, Lowe ME. Expression of a novel cadherin in the mouse and human intestine. Pediatr Res. 2004;55(6):927-34. PMID:15028844 
75. D'Agostino D, Lowe ME. Pancreatic lipase-related protein 2 is the major colipase-dependent pancreatic lipase in suckling mice. J Nutr. 2004;134(1):132-4. PMCID:PMC2528064  PMID:14704305 
76. Squire TL, Lowe ME, Bauer VW, Andrews MT. Pancreatic triacylglycerol lipase in a hibernating mammal. II. Cold-adapted function and differential expression. Physiol Genomics. 2003;16(1):131-40. PMID:14583599 
77. Tsujita T, Sumiyoshi M, Takaku T, Momsen WE, Lowe ME, Brockman HL. Inhibition of lipases by epsilon-polylysine. J Lipid Res. 2003;44(12):2278-86. PMID:12951365 
78. Rippe C, Berger K, Mei J, Lowe ME, Erlanson-Albertsson C. Effect of long-term high-fat feeding on the expression of pancreatic lipases and adipose tissue uncoupling proteins in mice. Pancreas. 2003;26(2):e36-42. PMCID:PMC3488857  PMID:12604926 
79. Imamura T, Asada M, Vogt SK, Rudnick DA, Lowe ME, Muglia LJ. Protection from pancreatitis by the zymogen granule membrane protein integral membrane-associated protein-1. J Biol Chem. 2002;277(52):50725-33. PMCID:PMC3701954  PMID:12401800 
80. Chahinian H, Bezzine S, Ferrato F, Ivanova MG, Perez B, Lowe ME, Carrière F. The beta 5' loop of the pancreatic lipase C2-like domain plays a critical role in the lipase-lipid interactions. Biochemistry. 2002;41(46):13725-35. PMID:12427035 
81. Keating JP, Lowe ME. Persistent hyperlipasemia caused by macrolipase in an adolescent. J Pediatr. 2002;141(1):129-31. PMID:12091864 
82. D'Agostino D, Cordle RA, Kullman J, Erlanson-Albertsson C, Muglia LJ, Lowe ME. Decreased postnatal survival and altered body weight regulation in procolipase-deficient mice. J Biol Chem. 2002;277(9):7170-7. PMCID:PMC2528063  PMID:11751900 
83. Bauer VW, Squire TL, Lowe ME, Andrews MT. Expression of a chimeric retroviral-lipase mRNA confers enhanced lipolysis in a hibernating mammal. Am J Physiol Regul Integr Comp Physiol. 2001;281(4):R1186-92. PMID:11557627 
84. Crandall WV, Lowe ME. Colipase residues Glu64 and Arg65 are essential for normal lipase-mediated fat digestion in the presence of bile salt micelles. J Biol Chem. 2001;276(16):12505-12. PMID:11278590 
85. Yang Y, Sanchez D, Figarella C, Lowe ME. Discoordinate expression of pancreatic lipase and two related proteins in the human fetal pancreas. Pediatr Res. 2000;47(2):184-8. PMID:10674344 
86. Yang Y, Lowe ME. The open lid mediates pancreatic lipase function. J Lipid Res. 2000;41(1):48-57. PMID:10627501 
87. Roussel A, Yang Y, Ferrato F, Verger R, Cambillau C, Lowe M. Structure and activity of rat pancreatic lipase-related protein 2. J Biol Chem. 1998;273(48):32121-8. PMID:9822688 
88. Lowe ME, Kaplan MH, Jackson-Grusby L, D'Agostino D, Grusby MJ. Decreased neonatal dietary fat absorption and T cell cytotoxicity in pancreatic lipase-related protein 2-deficient mice. J Biol Chem. 1998;273(47):31215-21. PMCID:PMC3690502  PMID:9813028 
89. Winzell MS, Lowe ME, Erlanson-Albertsson C. Rat gastric procolipase: sequence, expression, and secretion during high-fat feeding. Gastroenterology. 1998;115(5):1179-85. PMID:9797373 
90. Cordle RA, Lowe ME. The hydrophobic surface of colipase influences lipase activity at an oil-water interface. J Lipid Res. 1998;39(9):1759-67. PMID:9741688 
91. Cordle RA, Lowe ME. Purification and characterization of human procolipase expressed in yeast cells. Protein Expr Purif. 1998;13(1):30-5. PMID:9631511 
92. Yang Y, Lowe ME. Human pancreatic triglyceride lipase expressed in yeast cells: purification and characterization. Protein Expr Purif. 1998;13(1):36-40. PMID:9631512 
93. Lowe ME. Colipase stabilizes the lid domain of pancreatic triglyceride lipase. J Biol Chem. 1997;272(1):9-12. PMID:8995215 
94. Andersson L, Carriére F, Lowe ME, Nilsson A, Verger R. Pancreatic lipase-related protein 2 but not classical pancreatic lipase hydrolyzes galactolipids. Biochim Biophys Acta. 1996;1302(3):236-40. PMID:8765145 
95. Lowe ME. Mutation of the catalytic site Asp177 to Glu177 in human pancreatic lipase produces an active lipase with increased sensitivity to proteases. Biochim Biophys Acta. 1996;1302(2):177-83. PMID:8695668 
96. Kullman J, Gisi C, Lowe ME. Dexamethasone-regulated expression of pancreatic lipase and two related proteins in AR42J cells. Am J Physiol. 1996;270(5 Pt 1):G746-51. PMID:8967484 
97. Jennens ML, Lowe ME. Rat GP-3 is a pancreatic lipase with kinetic properties that differ from colipase-dependent pancreatic lipase. J Lipid Res. 1995;36(11):2374-82. PMID:8656075 
98. Jennens ML, Lowe ME. C-terminal domain of human pancreatic lipase is required for stability and maximal activity but not colipase reactivation. J Lipid Res. 1995;36(5):1029-36. PMID:7658150 
99. Lowe ME. Human pancreatic procolipase expressed in insect cells: purification and characterization. Protein Expr Purif. 1994;5(6):583-6. PMID:7858428 
100. Jennens ML, Lowe ME. A surface loop covering the active site of human pancreatic lipase influences interfacial activation and lipid binding. J Biol Chem. 1994;269(41):25470-4. PMID:7929247 
101. Payne RM, Sims HF, Jennens ML, Lowe ME. Rat pancreatic lipase and two related proteins: enzymatic properties and mRNA expression during development. Am J Physiol. 1994;266(5 Pt 1):G914-21. PMCID:PMC3523700  PMID:8203536 
102. Sims HF, Jennens ML, Lowe ME. The human pancreatic lipase-encoding gene: structure and conservation of an Alu sequence in the lipase gene family. Gene. 1993;131(2):281-5. PMID:8406023 
103. Lowe ME. The catalytic site residues and interfacial binding of human pancreatic lipase. J Biol Chem. 1992;267(24):17069-73. PMID:1512245 
104. Sims HF, Lowe ME. The human colipase gene: isolation, chromosomal location, and tissue-specific expression. Biochemistry. 1992;31(31):7120-5. PMID:1643046 
105. Kumar BV, Aleman-Gomez JA, Colwell N, Lopez-Candales A, Bosner MS, Spilburg CA, Lowe M, Lange LG. Structure of the human pancreatic cholesterol esterase gene. Biochemistry. 1992;31(26):6077-81. PMID:1627550 
106. Lowe ME. Site-specific mutations in the COOH-terminus of placental alkaline phosphatase: a single amino acid change converts a phosphatidylinositol-glycan-anchored protein to a secreted protein. J Cell Biol. 1992;116(3):799-807. PMCID:PMC2289307  PMID:1730777 
107. Long CA, Bauer GS, Lowe ME, Strauss AW, Gast MJ. Isolation and characterization of the gene from a human genome encoding 17 beta-estradiol dehydrogenase: a comparison of Jar and BeWo choriocarcinoma cell lines. Am J Obstet Gynecol. 1990;163(6 Pt 1):1976-81. PMID:2256510 
108. Lowe ME, Strauss AW. Expression of a Nagao-type, phosphatidylinositol-glycan anchored alkaline phosphatase in human choriocarcinomas. Cancer Res. 1990;50(13):3956-62. PMID:2162249 
109. Lowe M, Strauss AW, Alpers R, Seetharam S, Alpers DH. Molecular cloning and expression of a cDNA encoding the membrane-associated rat intestinal alkaline phosphatase. Biochim Biophys Acta. 1990;1037(2):170-7. PMID:2155025 
110. Lowe ME, Rosenblum JL, McEwen P, Strauss AW. Cloning and characterization of the human colipase cDNA. Biochemistry. 1990;29(3):823-8. PMID:2337598 
111. Lowe ME, Rosenblum JL, Strauss AW. Cloning and characterization of human pancreatic lipase cDNA. J Biol Chem. 1989;264(33):20042-8. PMID:2479644 
112. Lowe ME, Nilsson B. A method of purification of partially methylated alditol acetates in the methylation analysis of glycoproteins and glycopeptides. Anal Biochem. 1984;136(1):187-91. PMID:6711806 
113. Lowe M, Nilsson B. The structure of the complex type oligosaccharide from rabbit hepatic binding protein. A re-examination. J Biol Chem. 1983;258(3):1885-7. PMID:6822540 
114. Lowe ME, Kempner ES. Radiation inactivation of the glycoprotein, invertase. J Biol Chem. 1982;257(21):12478-80. PMID:6752136 
115. Harford J, Lowe M, Tsunoo H, Ashwell G. Immunological approaches to the study of membrane receptors. A monoclonal antibody that inhibits the binding of asialoglycoproteins to the rat liver receptor. J Biol Chem. 1982;257(21):12685-90. PMID:6290477 
116. Lowe ME, Ashwell G. Solubilization and assay of an hepatic receptor for the haptoglobin--hemoglobin complex. Arch Biochem Biophys. 1982;216(2):704-10. PMID:6287941 
117. West CM, Lanza R, Rosenbloom J, Lowe M, Holtzer H, Avdalovic N. Fibronectin alters the phenotypic properties of cultured chick embryo chondroblasts. Cell. 1979;17(3):491-501. PMID:476827 
118. Lowe ME, Pacifici M, Holtzer H. Effects of phorbol-12-myristate-13-acetate on the phenotypic program of cultured chondroblasts and fibroblasts. Cancer Res. 1978;38(8):2350-6. PMID:667832