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Mark E. Lowe, M.D., Ph.D.
lowe@wustl.edu
Vice Chair, Pediatrics Clinical Affairs and Strategic Planning
Professor, Gastroenterology, Hepatology and Nutrition
Gastroenterology, Hepatology and Nutrition
phone: (314) 454-6173
Education
BA,
Washington University
,
1973
PhD,
University of Pennsylvania
,
1977
MD,
University of Miami
,
1984
Training
Staff Fellow in Biochemistry, National Institutes of Health
,
1977
-
1980
Staff Fellow in Pediatric Metabolism, National Institutes of Health
,
1980
-
1981
Senior Staff Fellow in Pediatric Metabolism, National Institutes of Health
,
1981
-
1982
Pediatric Intern in Pediatrics, St. Louis Children’s Hospital
,
1984
-
1985
Pediatric Resident in Pediatrics, St. Louis Children’s Hospital
,
1985
-
1986
Pediatric Fellow in Gastroenterology, St. Louis Children’s Hospital
,
1986
-
1989
Licensure and Board Certification
1985
National Board of Medical Examiners
1986
-
Pres
DEA
1986
-
Pres
MO Missouri State BNDD
1986
-
Pres
MO Missouri State Medical License
1989
-
1995
Pediatrics - ABP
1995
-
Pres
Pediatric Gastroenterology - ABP
2014
-
Pres
The American Board of Pediatrics (ABP) Maintenance of Certification (MOC)
Honors and Awards
Omicron Delta Kappa
,
1973
AGA-Industry Scholar Award (declined)
,
1990
FIRST Award, National Institutes of Health
,
1990
American Heart Association Established Investigator
,
1992
Mead Johnson Nutritionals Award from the American Institute of Nutrition (Renamed the American Society for Nutritional Sciences)
,
1996
Courage for the Cure Award, National Pancreas Foundation
,
2010
Opponent, Thesis Defense, University of Lund Sweden
,
2010
Best Doctors in America
,
2012
- Pres
Carol Ann Craumer Endowed Chair for Pediatric Reseach
,
2015
- 2017
Fellow of the American Gastroenterological Association
,
2015
Best Doctors in St. Louis
,
2018
- Pres
Fellow, American Association for the Advancement of Science
,
2018
Harvey R. Colten Professor of Pediatric Science
,
2018
- Pres
AcademicKeys, Who's Who in Medicine Higher Education
,
2019
- Pres
NASPGHAN Shwachman Award,
,
2020
Collaborative Alliance of Pancreatic Education and Research (CAPER) Senior Mentor Achievement Award
,
2021
Recent Publications
view all (118)
Publication Co-Authors
David A. Rudnick, M.D., Ph.D.
Xunjun Xiao, Ph.D
Chinenye R Dike, Gretchen Cress, Douglas S Fishman, Tanja Gonska, Chee Y Ooi, Emily R Perito, David Troendle, Cynthia M Tsai, Mark E Lowe, Aliye Uc.
Vascular Complications in Pediatric Pancreatitis: A Case Series
J Pediatr Gastroenterol Nutr .
.
2021;73
(4):
e94-e97.
doi:
DOI: 10.1097/MPG.0000000000003218
PMCID:
PMCID: PMC8455425
PMID:
PMID: 34224489
Gravdal A, Xiao X, Cnop M, El Jellas K, Johansson S, Njølstad PR, Lowe ME, Johansson BB, Molven A, Fjeld K.
The position of single-base deletions in the VNTR sequence of the carboxyl ester lipase (CEL) gene determines proteotoxicity.
J Biol Chem
.
2021;100661.
PMID:
33862081
Khatua B, El-Kurdi B, Patel K, Rood C, Noel P, Crowell M, Yaron JR, Kostenko S, Guerra A, Faigel DO, Lowe M, Singh VP.
Adipose saturation reduces lipotoxic systemic inflammation and explains the obesity paradox.
Sci Adv
.
2021;7
(5).
PMCID:
PMC7846167
PMID:
33514548
Perito ER, Lowe ME, Schwarzenberg SJ.
Predicting Severity in Acute Pancreatitis in Children: What Can a Quantitative Score Add to Clinical Judgement?
J Pediatr Gastroenterol Nutr
.
2020;71
(4):
419-420.
PMID:
32740540
Cassidy BM, Zino S, Fjeld K, Molven A, Lowe ME, Xiao X.
Single nucleotide polymorphisms in CEL-HYB1 increase risk for chronic pancreatitis through proteotoxic misfolding.
Hum Mutat
.
2020.
PMID:
32906201
Abu-El-Haija M, Lowe M, Barth B, Bellin MD, Fishman DS, Freedman S, Gariepy C, Giefer MJ, Gonska T, Heyman MB, Himes R, Husain S, Lin TK, Liu Q, Mascarenhas MR, Maqbool A, McFerron B, Morinville V, Nathan J, Ooi CY, Perito E, Pohl JF, Schwarzenberg SJ, Shah U, Troendle D, Werlin S, Wilschanski M, Zimmerman B, Uc A.
Pediatric chronic pancreatitis without prior acute or acute recurrent pancreatitis: A report from the INSPPIRE consortium.
Pancreatology
.
2020;20
(4):
781-784.
PMCID:
PMC7781353
PMID:
32332002
Dike CR, Zimmerman B, Zheng Y, Wilschanski M, Werlin SL, Troendle D, Shah U, Schwarzenberg SJ, Pohl J, Perito ER, Ooi CY, Nathan JD, Morinville VD, McFerron B, Mascarenhas M, Maqbool A, Liu Q, Lin TK, Husain SZ, Heyman MB, Gonska T, Giefer MJ, Gariepy CE, Fishman DS, Bellin M, Barth B, Abu-El-Haija M, Lowe ME, Uc A.
Clinical and Practice Variations in Pediatric Acute Recurrent or Chronic Pancreatitis: Report From The Insppire Study.
J Pediatr Gastroenterol Nutr
.
2020;71
(1):
112-8.
doi:
10.1097/MPG.0000000000002661
PMCID:
PMC7305964
PMID:
32079978
de Oliveira C, Khatua B, Noel P, Kostenko S, Bag A, Balakrishnan B, Patel KS, Guerra AA, Martinez MN, Trivedi S, McCullough AE, Lam-Himlin DM, Navina S, Faigel DO, Fukami N, Pannala R, Evans Phillips A, Papachristou GI, Kershaw EE, Lowe ME, Singh VP.
Pancreatic triglyceride lipase mediates lipotoxic systemic inflammation.
J Clin Invest
.
2020;130
(4):
1931-47.
doi:
10.1172/JCI132767
PMCID:
PMC7108918
PMID:
31917686
Perito ER, Palermo TM, Pohl JF, Mascarenhas M, Abu-El-Haija M, Barth B, Bellin MD, Fishman DS, Freedman S, Gariepy C, Giefer M, Gonska T, Heyman MB, Himes RW, Husain SZ, Lin T, Liu Q, Maqbool A, McFerron B, Morinville VD, Nathan JD, Ooi CY, Rhee S, Schwarzenberg SJ, Shah U, Troendle DM, Werlin S, Wilschanski M, Zheng Y, Zimmerman MB, Lowe M, Uc A.
Factors Associated With Frequent Opioid Use in Children With Acute Recurrent and Chronic Pancreatitis.
J Pediatr Gastroenterol Nutr
.
2020;70
(1):
106-114.
PMCID:
PMC6934913
PMID:
31567889
Palermo TM, Murray C, Aalfs H, Abu-El-Haija M, Barth B, Bellin MD, Ellery K, Fishman DS, Gariepy CE, Giefer MJ, Goday P, Gonska T, Heyman MB, Husain SZ, Lin TK, Liu QY, Mascarenhas MR, Maqbool A, McFerron B, Morinville VD, Nathan JD, Ooi CY, Perito ER, Pohl JF, Schwarzenberg SJ, Sellers ZM, Serrano J, Shah U, Troendle D, Zheng Y, Yuan Y, Lowe M, Uc A, Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer..
Web-based cognitive-behavioral intervention for pain in pediatric acute recurrent and chronic pancreatitis: Protocol of a multicenter randomized controlled trial from the study of chronic pancreatitis, diabetes and pancreatic cancer (CPDPC).
Contemp Clin Trials
.
2020;88:105898.
PMCID:
PMC6952537
PMID:
31756383
Lowe ME, Andersen DK, Caprioli RM, Choudhary J, Cruz-Monserrate Z, Dasyam AK, Forsmark CE, Gorelick FS, Gray JW, Haupt M, Kelly KA, Olive KP, Plevritis SK, Rappaport N, Roth HR, Steen H, Swamidass SJ, Tirkes T, Uc A, Veselkov K, Whitcomb DC, Habtezion A.
Precision Medicine in Pancreatic Disease-Knowledge Gaps and Research Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.
Pancreas
.
2019;48
(10):
1250-1258.
PMID:
31688587
Bellin MD, Lowe M, Zimmerman MB, Wilschanski M, Werlin S, Troendle DM, Shah U, Schwarzenberg SJ, Pohl JF, Perito E, Ooi CY, Nathan JD, Morinville VD, McFerron BA, Mascarenhas MR, Maqbool A, Liu Q, Lin TK, Husain SZ, Himes R, Heyman MB, Gonska T, Giefer MJ, Gariepy CE, Freedman SD, Fishman DS, Barth B, Abu-El-Haija M, Uc A.
Diabetes Mellitus in Children with Acute Recurrent and Chronic Pancreatitis: Data From the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort.
J Pediatr Gastroenterol Nutr
.
2019;69
(5):
599-606.
PMCID:
PMC6834233
PMID:
31651815
Lin TK, Fishman DS, Giefer MJ, Liu QY, Troendle D, Werlin S, Lowe ME, Uc A.
Functional Pancreatic Sphincter Dysfunction in Children: Recommendations for Diagnosis and Management.
J Pediatr Gastroenterol Nutr
.
2019.
PMID:
31567892
Liu QY, Abu-El-Haija M, Husain SZ, Barth B, Bellin M, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes R, Lin TK, Maqbool A, Mascarenhas M, McFerron BA, Morinville VD, Nathan JD, Ooi CY, Perito ER, Pohl JF, Rhee S, Schwarzenberg SJ, Shah U, Troendle D, Werlin SL, Wilschanski M, Zimmerman MB, Lowe ME, Uc A.
Risk Factors for Rapid Progression From Acute Recurrent to Chronic Pancreatitis in Children: Report From INSPPIRE.
J Pediatr Gastroenterol Nutr
.
2019;69
(2):
206-211.
PMCID:
PMC6699635
PMID:
31136562
Lasher D, Szabó A, Masamune A, Chen JM, Xiao X, Whitcomb DC, Barmada MM, Ewers M, Ruffert C, Paliwal S, Issarapu P, Bhaskar S, Mani KR, Chandak GR, Laumen H, Masson E, Kume K, Hamada S, Nakano E, Seltsam K, Bugert P, Müller T, Groneberg DA, Shimosegawa T, Rosendahl J, Férec C, Lowe ME, Witt H, Sahin-Tóth M.
Protease-Sensitive Pancreatic Lipase Variants Are Associated With Early Onset Chronic Pancreatitis.
Am J Gastroenterol
.
2019;114
(6):
974-983.
PMCID:
PMC6624845
PMID:
30789418
Schwarzenberg SJ, Uc A, Zimmerman B, Wilschanski M, Wilcox CM, Whitcomb DC, Werlin SL, Troendle D, Tang G, Slivka A, Singh VK, Sherman S, Shah U, Sandhu BS, Romagnuolo J, Rhee S, Pohl JF, Perito ER, Ooi CY, Nathan JD, Muniraj T, Morinville VD, McFerron B, Mascarenhas M, Maqbool A, Liu Q, Lin TK, Lewis M, Husain SZ, Himes R, Heyman MB, Guda N, Gonska T, Giefer MJ, Gelrud A, Gariepy CE, Gardner TB, Freedman SD, Forsmark CE, Fishman DS, Cote GA, Conwell D, Brand RE, Bellin M, Barth B, Banks PA, Anderson MA, Amann ST, Alkaade S, Abu-El-Haija M, Abberbock JN, Lowe ME, Yadav D.
Chronic Pancreatitis: Pediatric and Adult Cohorts Show Similarities in Disease Progress Despite Different Risk Factors.
J Pediatr Gastroenterol Nutr
.
2019;68
(4):
566-573.
PMID:
30897605
Grover AS, Freeman AJ, Abu-El-Haija M, Eisses JF, Gardner TB, Liu QY, Lowe ME, Nathan JD, Palermo TM, Singh VK, Trout AT, Uc A, Husain SZ, Morinville VD.
Updates in Pediatric Pancreatology: Proceedings of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Frontiers in Pediatric Pancreatology Symposium.
J Pediatr Gastroenterol Nutr
.
2019;68
(2):
e27-e33.
PMID:
30888340
Abu-El-Haija M, Lowe ME.
Pediatric Pancreatitis-Molecular Mechanisms and Management.
Gastroenterol Clin North Am
.
2018;47
(4):
741-753.
PMID:
30337030
Nemeth BC, Pesei ZG, Hegyi E, Szucs A, Szentesi A, Hegyi P, Lowe ME, Sahin-Toth M.
The common truncation variant in pancreatic lipase related protein 2 (PNLIPRP2) is expressed poorly and does not alter risk for chronic pancreatitis
PLoS One
.
2018;13
(11):
e0206869.
PMCID:
6226108
PMID:
30408063
Uc A, Perito ER, Pohl JF, Shah U, Abu-El-Haija M, Barth B, Bellin MD, Ellery KM, Fishman DS, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes RW, Husain SZ, Maqbool A, Mascarenhas MR, McFerron BA, Morinville VD, Lin TK, Liu QY, Nathan JD, Rhee SJ, Ooi CY, Sellers ZM, Schwarzenberg SJ, Serrano J, Troendle DM, Werlin SL, Wilschanski M, Zheng Y, Yuan Y, Lowe ME, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)..
INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort Study: Design and Rationale for INSPPIRE 2 From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer.
Pancreas
.
2018;47
(10):
1222-1228.
PMCID:
PMC6195325
PMID:
30325861
Lowe ME, Goodman MT, Coté GA, Glesby MJ, Haupt M, Schork NJ, Singh VK, Andersen DK, Pandol SJ, Uc A, Whitcomb DC.
Accelerating the Drug Delivery Pipeline for Acute and Chronic Pancreatitis: Summary of the Working Group on Drug Development and Trials in Recurrent Acute Pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases Workshop.
Pancreas
.
2018;47
(10):
1193-1199.
PMCID:
PMC6195328
PMID:
30325857
Fisher WE, Cruz-Monserrate Z, McElhany AL, Lesinski GB, Hart PA, Ghosh R, Van Buren G, Fishman DS, Rinaudo JAS, Serrano J, Srivastava S, Mace T, Topazian M, Feng Z, Yadav D, Pandol SJ, Hughes SJ, Liu RY, Lu E, Orr R, Whitcomb DC, Abouhamze AS, Steen H, Sellers ZM, Troendle DM, Uc A, Lowe ME, Conwell DL, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)..
Standard Operating Procedures for Biospecimen Collection, Processing, and Storage: From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer.
Pancreas
.
2018;47
(10):
1213-1221.
PMCID:
PMC6197069
PMID:
30325860
El Jellas K, Johansson BB, Fjeld K, Antonopoulos A, Immervoll H, Choi MH, Hoem D, Lowe ME, Lombardo D, Njølstad PR, Dell A, Mas E, Haslam SM, Molven A.
The mucinous domain of pancreatic carboxyl-ester lipase (CEL) contains core 1/core 2 O-glycans that can be modified by ABO blood group determinants.
J Biol Chem
.
2018;293
(50):
19476-91.
PMCID:
6302156
PMID:
30315106
Scheers I, Palermo JJ, Freedman S, Wilschanski M, Shah U, Abu-El-Haija M, Barth B, Fishman DS, Gariepy C, Giefer MJ, Heyman MB, Himes RW, Husain SZ, Lin TK, Liu Q, Lowe M, Mascarenhas M, Morinville V, Ooi CY, Perito ER, Piccoli DA, Pohl JF, Schwarzenberg SJ, Troendle D, Werlin S, Zimmerman B, Uc A, Gonska T..
Recommendations for Diagnosis and Management of Autoimmune Pancreatitis in Childhood: Consensus From INSPPIRE
J Pediatr Gastroenterol Nutri
.
2018;67
(2):
232-236.
PMCID:
6059991
PMID:
29746340
Uc A, Zimmerman MB, Wilschanski M, Werlin SL, Troendle D, Shah U, Schwarzenberg SJ, Rhee S, Pohl JF, Perito ER, Palermo JJ, Ooi CY, Liu Q, Lin TK, Morinville VD, McFerron BA, Husain SZ, Himes R, Heyman MB, Gonska T, Giefer MJ, Gariepy CE, Freedman SD, Fishman DS, Bellin MD, Barth B, Abu-El-Haija M, Lowe ME.
Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis.
Pancreas
.
2018.
PMID:
30059474
Lin TK, Abu-El-Haija M, Nathan JD, Palermo JP, Barth B, Bellin M, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes R, Husain SZ, Liu Q, Maqbool A, Mascarenhas M, McFerron B, Morinville VD, Ooi CY, Perito E, Pohl JF, Rhee S, Schwarzenberg SJ, Shah U, Troendle D, Werlin SL, Wilschanski M, Zimmerman MB, Lowe ME, Uc A.
Pancreas Divisum in Pediatric Acute Recurrent and Chronic Pancreatitis: Report From INSPPIRE.
J Clin Gastroenterol
.
2018.
PMID:
29864067
Parniczky A, Abu-El-Haija M, Husain S, Lowe M, Oracz G, Sahin-Toth M, Szabo FK, Uc A, Wilschanski M, Witt H, Czako L, Grammatikopoulos T, Rasmussen IC, Sutton R, Hegyi P.
EPC/HPSG evidence-based guidelines for the management of pediatric pancreatitis
Pancreatology
.
2018;18
(2).
doi:
10.1016/j.pan.2018.01.001
PMID:
29398347
Scheers I, Palermo JJ, Freedman S4 Wilschanski M5 Shah U6 Abu-El-Haija M3 Barth B7 Fishman DS8 Gariepy C9 Giefer MJ, Heyman MB, Himes RW, Husain SZ, Lin TK, Liu Q, Lowe M, Mascarenhas M, Morinville V, Ooi CY, Perito ER, Piccoli DA, Pohl JF, Schwarzenberg SJ, Troendle D, Werlin S, Zimmerman B, Uc A, Gonska T..
Autoimmune Pancreatitis in Children: Characteristic Features, Diagnosis, and Management.
Am J Gastroenterol
.
2017;2
(10):
1604-1611.
doi:
10.1038/ajg.2017.85
PMCID:
5908471
PMID:
28374818
Giefer MJ, Lowe ME, Werlin SL, Zimmerman B, Wilschanski M, Troendle D, Schwarzenberg SJ, Pohl JF, Palermo J, Ooi CY, Morinville VD, Lin TK, Husain SZ, Himes R, Heyman MB, Gonska T, Gariepy CE, Freedman SD, Fishman DS, Bellin MD, Barth B, Abu-El-Haija M, Uc A.
Early-Onset Acute Recurrent and Chronic Pancreatitis Is Associated with PRSS1 or CTRC Gene Mutations.
J Pediatr
.
2017;186:95-100.
PMCID:
PMC5506853
PMID:
28502372
Troendle DM, Fishman DS, Barth BA, Giefer MJ, Lin TK, Liu QY, Abu-El-Haija M, Bellin MD, Durie PR, Freedman SD, Gariepy C, Gonska T, Heyman MB, Himes R, Husain SZ, Kumar S, Lowe ME, Morinville VD, Ooi CY, Palermo J, Pohl JF, Schwarzenberg SJ, Werlin S, Wilschanski M, Zimmerman MB, Uc A.
Therapeutic Endoscopic Retrograde Cholangiopancreatography in Pediatric Patients With Acute Recurrent and Chronic Pancreatitis: Data From the INSPPIRE (INternational Study group of Pediatric Pancreatitis: In search for a cuRE) Study.
Pancreas
.
2017;46
(6):
764-769.
PMCID:
PMC5502745
PMID:
28609364
Oparaji JA, Rose F, Okafor D, Howard A, Turner RL, Orabi AI, Byersdorfer C, Mi Q, Ritchey K, Lowe ME, Husain SZ.
Risk Factors for Asparaginase-associated Pancreatitis: A Systematic Review.
J Clin Gastroenterol
.
2017.
PMID:
28375864
Gariepy CE, Heyman MB, Lowe ME, Pohl JF, Werlin SL, Wilschanski M, Barth B, Fishman DS, Freedman SD, Giefer MJ, Gonska T, Himes R, Husain SZ, Morinville VD, Ooi CY, Schwarzenberg SJ, Troendle DM, Yen E, Uc A.
Causal Evaluation of Acute Recurrent and Chronic Pancreatitis in Children: Consensus From the INSPPIRE Group.
J Pediatr Gastroenterol Nutr
.
2017;64
(1):
95-103.
PMCID:
PMC5191966
PMID:
27782962
Uc A, Andersen DK, Bellin MD, Bruce JI, Drewes AM, Engelhardt JF, Forsmark CE, Lerch MM, Lowe ME, Neuschwander-Tetri BA, OʼKeefe SJ, Palermo TM, Pasricha P, Saluja AK, Singh VK, Szigethy EM, Whitcomb DC, Yadav D, Conwell DL.
Chronic Pancreatitis in the 21st Century - Research Challenges and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.
Pancreas
.
2016;45
(10):
1365-1375.
PMCID:
PMC5117429
PMID:
27748719
Xiao X, Jones G, Sevilla WA, Stolz DB, Magee KE, Haughney M, Mukherjee A, Wang Y, Lowe ME.
A Carboxyl Ester Lipase (CEL) Mutant Causes Chronic Pancreatitis by Forming Intracellular Aggregates That Activate Apoptosis.
J Biol Chem
.
2016;291
(44):
23224-23236.
PMCID:
PMC5087739
PMID:
27650499
Kumar S, Ooi CY, Werlin S, Abu-El-Haija M, Barth B, Bellin MD, Durie PR, Fishman DS, Freedman SD, Gariepy C, Giefer MJ, Gonska T, Heyman MB, Himes R, Husain SZ, Lin TK, Lowe ME, Morinville V, Palermo JJ, Pohl JF, Schwarzenberg SJ, Troendle D, Wilschanski M, Zimmerman MB, Uc A.
Risk Factors Associated With Pediatric Acute Recurrent and Chronic Pancreatitis: Lessons From INSPPIRE.
JAMA Pediatr
.
2016;170
(6):
562-9.
PMCID:
PMC5317277
PMID:
27064572
Szabo FK, Hornung L, Oparaji JA, Alhosh R, Husain SZ, Liu QY, Palermo J, Lin TK, Nathan JD, Podberesky DJ, Lowe M, Fei L, Abu-El-Haija M.
A prognostic tool to predict severe acute pancreatitis in pediatrics.
Pancreatology
.
2016;16
(3):
358-64.
PMID:
27051062
Ting J, Wilson L, Schwarzenberg SJ, Himes R, Barth B, Bellin MD, Durie PR, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Husain SZ, Kumar S, Morinville VD, Lowe ME, Ooi CY, Pohl JF, Troendle D, Usatin D, Werlin SL, Wilschanski M, Heyman MB, Uc A.
Direct Costs of Acute Recurrent and Chronic Pancreatitis in Children in the INSPPIRE Registry.
J Pediatr Gastroenterol Nutr
.
2016;62
(3):
443-9.
PMCID:
PMC4767646
PMID:
26704866
Eisses JF, Criscimanna A, Dionise ZR, Orabi AI, Javed TA, Sarwar S, Jin S, Zhou L, Singh S, Poddar M, Davis AW, Tosun AB, Ozolek JA, Lowe ME, Monga SP, Rohde GK, Esni F, Husain SZ.
Valproic Acid Limits Pancreatic Recovery after Pancreatitis by Inhibiting Histone Deacetylases and Preventing Acinar Redifferentiation Programs.
Am J Pathol
.
2015;185
(12):
3304-15.
PMCID:
PMC4729237
PMID:
26476347
Xiao X, Lowe ME.
The β5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 (PNLIPRP2).
J Biol Chem
.
2015;290
(48):
28847-56.
PMCID:
PMC4661400
PMID:
26494624
Szabó A, Xiao X, Haughney M, Spector A, Sahin-Tóth M, Lowe ME.
A novel mutation in PNLIP causes pancreatic triglyceride lipase deficiency through protein misfolding.
Biochim Biophys Acta
.
2015;1852
(7):
1372-9.
PMCID:
PMC4645278
PMID:
25862608
Calabuig-Navarro V, Yamauchi J, Lee S, Zhang T, Liu YZ, Sadlek K, Coudriet GM, Piganelli JD, Jiang CL, Miller R, Lowe M, Harashima H, Dong HH.
Forkhead Box O6 (FoxO6) Depletion Attenuates Hepatic Gluconeogenesis and Protects against Fat-induced Glucose Disorder in Mice.
J Biol Chem
.
2015;290
(25):
15581-94.
PMCID:
PMC4505471
PMID:
25944898
Loverdos I, Swan MC, Shekherdimian S, Al-Rasheed AA, Schneider R, Fish JS, Ngan BY, Adeli K, Lowe ME, Singh VP, Sevilla WM, Langer JC, Gonska T.
A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition.
J Pediatr Surg Case Rep
.
2015;3
(5):
223-226.
PMCID:
PMC4864014
PMID:
27182490
Schwarzenberg SJ, Bellin M, Husain SZ, Ahuja M, Barth B, Davis H, Durie PR, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes R, Kumar S, Morinville VD, Lowe ME, Nuehring NE, Ooi CY, Pohl JF, Troendle D, Werlin SL, Wilschanski M, Yen E, Uc A.
Pediatric chronic pancreatitis is associated with genetic risk factors and substantial disease burden.
J Pediatr
.
2015;166
(4):
890-896.e1.
PMCID:
PMC4380827
PMID:
25556020
Schwarzenberg SJ, Bellin M, Husain SZ, Ahuja M, Barth B, Davis H, Durie PR, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes R, Kumar S, Morinville VD, Lowe ME, Nuehring NE, Ooi CY, Pohl JF, Troendle D, Werlin SL, Wilschanski M, Yen E, Uc A.
Pediatric chronic pancreatitis is associated with genetic risk factors and substantial disease burden
J Pediatr
.
2015;166
(4):
890-6 e1.
PMID:
25556020
Morinville VD, Lowe ME, Ahuja M, Barth B, Bellin MD, Davis H, Durie PR, Finley B, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes R, Husain S, Kumar S, Ooi CY, Pohl JF, Schwarzenberg SJ, Troendle D, Werlin SL, Wilschanski M, Yen E, Uc A.
Design and implementation of INSPPIRE.
J Pediatr Gastroenterol Nutr
.
2014;59
(3):
360-4.
PMCID:
PMC4141003
PMID:
24824361
Singhi AD, Pai RK, Kant JA, Bartholow TL, Zeh HJ, Lee KK, Wijkstrom M, Yadav D, Bottino R, Brand RE, Chennat JS, Lowe ME, Papachristou GI, Slivka A, Whitcomb DC, Humar A.
The histopathology of PRSS1 hereditary pancreatitis.
Am J Surg Pathol
.
2014;38
(3):
346-53.
PMCID:
PMC4321743
PMID:
24525505
Srinath A, Wendel D, Bond G, Lowe M.
Visual diagnosis: 12-year-old girl with constipation and rectal bleeding.
Pediatr Rev
.
2014;35
(2):
e11-4.
PMID:
24488834
Bellin MD, Freeman ML, Gelrud A, Slivka A, Clavel A, Humar A, Schwarzenberg SJ, Lowe ME, Rickels MR, Whitcomb DC, Matthews JB, PancreasFest Recommendation Conference Participants., Amann S, Andersen DK, Anderson MA, Baillie J, Block G, Brand R, Chari S, Cook M, Cote GA, Dunn T, Frulloni L, Greer JB, Hollingsworth MA, Kim KM, Larson A, Lerch MM, Lin T, Muniraj T, Robertson RP, Sclair S, Singh S, Stopczynski R, Toledo FG, Wilcox CM, Windsor J, Yadav D.
Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest.
Pancreatology
.
2014;14
(1):
27-35.
PMCID:
PMC4058640
PMID:
24555976
Xiao X, Ross LE, Sevilla WA, Wang Y, Lowe ME.
Porcine pancreatic lipase related protein 2 has high triglyceride lipase activity in the absence of colipase.
Biochim Biophys Acta
.
2013;1831
(9):
1435-41.
PMCID:
PMC3742628
PMID:
23770034
Johnson K, Ross L, Miller R, Xiao X, Lowe ME.
Pancreatic lipase-related protein 2 digests fats in human milk and formula in concert with gastric lipase and carboxyl ester lipase.
Pediatr Res
.
2013;74
(2):
127-32.
PMCID:
PMC3737390
PMID:
23732775
Rickels MR, Bellin M, Toledo FG, Robertson RP, Andersen DK, Chari ST, Brand R, Frulloni L, Anderson MA, Whitcomb DC, PancreasFest Recommendation Conference Participants..
Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis: recommendations from PancreasFest 2012.
Pancreatology
.
2013;13
(4):
336-42.
PMCID:
PMC3830751
PMID:
23890130
Ross LE, Xiao X, Lowe ME.
Identification of amino acids in human colipase that mediate adsorption to lipid emulsions and mixed micelles.
Biochim Biophys Acta
.
2013;1831
(6):
1052-9.
PMCID:
PMC3642234
PMID:
23470256
Xiao X, Ferguson MR, Magee KE, Hale PD, Wang Y, Lowe ME.
The Arg92Cys colipase polymorphism impairs function and secretion by increasing protein misfolding.
J Lipid Res
.
2013;54
(2):
514-21.
PMCID:
PMC3837459
PMID:
23204298
Morinville VD, Husain SZ, Bai H, Barth B, Alhosh R, Durie PR, Freedman SD, Himes R, Lowe ME, Pohl J, Werlin S, Wilschanski M, Uc A, INSPPIRE Group..
Definitions of pediatric pancreatitis and survey of present clinical practices.
J Pediatr Gastroenterol Nutr
.
2012;55
(3):
261-5.
PMCID:
PMC3626452
PMID:
22357117
Orabi AI, Luo Y, Ahmad MU, Shah AU, Mannan Z, Wang D, Sarwar S, Muili KA, Shugrue C, Kolodecik TR, Singh VP, Lowe ME, Thrower E, Chen J, Husain SZ.
IP3 receptor type 2 deficiency is associated with a secretory defect in the pancreatic acinar cell and an accumulation of zymogen granules.
PLoS One
.
2012;7
(11):
e48465.
PMCID:
PMC3504040
PMID:
23185258
Xiao X, Mukherjee A, Ross LE, Lowe ME.
Pancreatic lipase-related protein-2 (PLRP2) can contribute to dietary fat digestion in human newborns.
J Biol Chem
.
2011;286
(30):
26353-63.
PMCID:
PMC3143598
PMID:
21652702
Xiao X, Ross LE, Miller RA, Lowe ME.
Kinetic properties of mouse pancreatic lipase-related protein-2 suggest the mouse may not model human fat digestion.
J Lipid Res
.
2011;52
(5):
982-90.
PMCID:
PMC3073462
PMID:
21382969
Bai HX, Lowe ME, Husain SZ.
What have we learned about acute pancreatitis in children?
J Pediatr Gastroenterol Nutr
.
2011;52
(3):
262-70.
PMCID:
PMC3626416
PMID:
21336157
McGuire BM, Zupanets IA, Lowe ME, Xiao X, Syplyviy VA, Monteleone J, Gargosky S, Dickinson K, Martinez A, Mokhtarani M, Scharschmidt BF.
Pharmacology and safety of glycerol phenylbutyrate in healthy adults and adults with cirrhosis.
Hepatology
.
2010;51
(6):
2077-85.
PMCID:
PMC3733097
PMID:
20512995
Morinville VD, Barmada MM, Lowe ME.
Increasing incidence of acute pancreatitis at an American pediatric tertiary care center: is greater awareness among physicians responsible?
Pancreas
.
2010;39
(1):
5-8.
PMID:
19752770
Miller R, D'Agostino D, Erlanson-Albertsson C, Lowe ME.
Enterostatin deficiency increases serum cholesterol but does not influence growth and food intake in mice.
Am J Physiol Endocrinol Metab
.
2009;297
(4):
E856-65.
PMCID:
PMC2763786
PMID:
19622781
Alves BN, Leong J, Tamang DL, Elliott V, Edelnant J, Redelman D, Singer CA, Kuhn AR, Miller R, Lowe ME, Hudig D.
Pancreatic lipase-related protein 2 (PLRP2) induction by IL-4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity.
J Leukoc Biol
.
2009;86
(3):
701-12.
PMCID:
PMC2735286
PMID:
19451396
Alves BN, Marshall K, Tamang DL, Leong J, Redelman D, Elliott V, Lowe ME, Hudig D.
Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs).
Cell Biochem Funct
.
2009;27
(5):
296-308.
PMCID:
PMC2837949
PMID:
19548271
Bourbon-Freie A, Dub RE, Xiao X, Lowe ME.
Trp-107 and trp-253 account for the increased steady state fluorescence that accompanies the conformational change in human pancreatic triglyceride lipase induced by tetrahydrolipstatin and bile salt.
J Biol Chem
.
2009;284
(21):
14157-64.
PMCID:
PMC2682864
PMID:
19346257
Alves B, Leong J, Tamang DL, Elliott V, Lowe M, Hudig D.
Hydrolysis of tumor cell lipids after CTL-mediated death.
Int Immunol
.
2009;21
(5):
543-53.
PMCID:
PMC2733839
PMID:
19325035
Miller R, Lowe ME.
Carboxyl ester lipase from either mother's milk or the pancreas is required for efficient dietary triglyceride digestion in suckling mice.
J Nutr
.
2008;138
(5):
927-30.
PMCID:
PMC3687517
PMID:
18424603
Kandula L, Lowe ME.
Etiology and outcome of acute pancreatitis in infants and toddlers.
J Pediatr
.
2008;152
(1):
106-10, 110.e1.
PMID:
18154910
Li X, Lindquist S, Lowe M, Noppa L, Hernell O.
Bile salt-stimulated lipase and pancreatic lipase-related protein 2 are the dominating lipases in neonatal fat digestion in mice and rats.
Pediatr Res
.
2007;62
(5):
537-41.
PMCID:
PMC3488855
PMID:
17805199
Morinville VD, Lowe ME, Elinoff BD, Whitcomb DC.
Hereditary pancreatitis amlodipine trial: a pilot study of a calcium-channel blocker in hereditary pancreatitis.
Pancreas
.
2007;35
(4):
308-12.
PMID:
18090235
D'Silva S, Xiao X, Lowe ME.
A polymorphism in the gene encoding procolipase produces a colipase, Arg92Cys, with decreased function against long-chain triglycerides.
J Lipid Res
.
2007;48
(11):
2478-84.
PMCID:
PMC3684974
PMID:
17715423
Kandula L, Khan S, Whitcomb DC, Lowe ME.
Acute pancreatitis in association with Campylobacter jejuni-associated diarrhea in a 15-year-old with CFTR mutations: is there a link?
JOP
.
2006;7
(5):
482-5.
PMID:
16998246
Freie AB, Ferrato F, Carrière F, Lowe ME.
Val-407 and Ile-408 in the beta5'-loop of pancreatic lipase mediate lipase-colipase interactions in the presence of bile salt micelles.
J Biol Chem
.
2006;281
(12):
7793-800.
PMCID:
PMC3695395
PMID:
16431912
Momsen WE, Mizuno NK, Lowe ME, Brockman HL.
Real-time measurement of solute partitioning to lipid monolayers.
Anal Biochem
.
2005;346
(1):
139-49.
PMID:
16188221
Moulton DE, Crandall W, Lakhani R, Lowe ME.
Expression of a novel cadherin in the mouse and human intestine.
Pediatr Res
.
2004;55
(6):
927-34.
PMID:
15028844
D'Agostino D, Lowe ME.
Pancreatic lipase-related protein 2 is the major colipase-dependent pancreatic lipase in suckling mice.
J Nutr
.
2004;134
(1):
132-4.
PMCID:
PMC2528064
PMID:
14704305
Squire TL, Lowe ME, Bauer VW, Andrews MT.
Pancreatic triacylglycerol lipase in a hibernating mammal. II. Cold-adapted function and differential expression.
Physiol Genomics
.
2003;16
(1):
131-40.
PMID:
14583599
Tsujita T, Sumiyoshi M, Takaku T, Momsen WE, Lowe ME, Brockman HL.
Inhibition of lipases by epsilon-polylysine.
J Lipid Res
.
2003;44
(12):
2278-86.
PMID:
12951365
Rippe C, Berger K, Mei J, Lowe ME, Erlanson-Albertsson C.
Effect of long-term high-fat feeding on the expression of pancreatic lipases and adipose tissue uncoupling proteins in mice.
Pancreas
.
2003;26
(2):
e36-42.
PMCID:
PMC3488857
PMID:
12604926
Imamura T, Asada M, Vogt SK, Rudnick DA, Lowe ME, Muglia LJ.
Protection from pancreatitis by the zymogen granule membrane protein integral membrane-associated protein-1.
J Biol Chem
.
2002;277
(52):
50725-33.
PMCID:
PMC3701954
PMID:
12401800
Chahinian H, Bezzine S, Ferrato F, Ivanova MG, Perez B, Lowe ME, Carrière F.
The beta 5' loop of the pancreatic lipase C2-like domain plays a critical role in the lipase-lipid interactions.
Biochemistry
.
2002;41
(46):
13725-35.
PMID:
12427035
Keating JP, Lowe ME.
Persistent hyperlipasemia caused by macrolipase in an adolescent.
J Pediatr
.
2002;141
(1):
129-31.
PMID:
12091864
D'Agostino D, Cordle RA, Kullman J, Erlanson-Albertsson C, Muglia LJ, Lowe ME.
Decreased postnatal survival and altered body weight regulation in procolipase-deficient mice.
J Biol Chem
.
2002;277
(9):
7170-7.
PMCID:
PMC2528063
PMID:
11751900
Bauer VW, Squire TL, Lowe ME, Andrews MT.
Expression of a chimeric retroviral-lipase mRNA confers enhanced lipolysis in a hibernating mammal.
Am J Physiol Regul Integr Comp Physiol
.
2001;281
(4):
R1186-92.
PMID:
11557627
Crandall WV, Lowe ME.
Colipase residues Glu64 and Arg65 are essential for normal lipase-mediated fat digestion in the presence of bile salt micelles.
J Biol Chem
.
2001;276
(16):
12505-12.
PMID:
11278590
Yang Y, Sanchez D, Figarella C, Lowe ME.
Discoordinate expression of pancreatic lipase and two related proteins in the human fetal pancreas.
Pediatr Res
.
2000;47
(2):
184-8.
PMID:
10674344
Yang Y, Lowe ME.
The open lid mediates pancreatic lipase function.
J Lipid Res
.
2000;41
(1):
48-57.
PMID:
10627501
Roussel A, Yang Y, Ferrato F, Verger R, Cambillau C, Lowe M.
Structure and activity of rat pancreatic lipase-related protein 2.
J Biol Chem
.
1998;273
(48):
32121-8.
PMID:
9822688
Lowe ME, Kaplan MH, Jackson-Grusby L, D'Agostino D, Grusby MJ.
Decreased neonatal dietary fat absorption and T cell cytotoxicity in pancreatic lipase-related protein 2-deficient mice.
J Biol Chem
.
1998;273
(47):
31215-21.
PMCID:
PMC3690502
PMID:
9813028
Winzell MS, Lowe ME, Erlanson-Albertsson C.
Rat gastric procolipase: sequence, expression, and secretion during high-fat feeding.
Gastroenterology
.
1998;115
(5):
1179-85.
PMID:
9797373
Cordle RA, Lowe ME.
The hydrophobic surface of colipase influences lipase activity at an oil-water interface.
J Lipid Res
.
1998;39
(9):
1759-67.
PMID:
9741688
Cordle RA, Lowe ME.
Purification and characterization of human procolipase expressed in yeast cells.
Protein Expr Purif
.
1998;13
(1):
30-5.
PMID:
9631511
Yang Y, Lowe ME.
Human pancreatic triglyceride lipase expressed in yeast cells: purification and characterization.
Protein Expr Purif
.
1998;13
(1):
36-40.
PMID:
9631512
Lowe ME.
Colipase stabilizes the lid domain of pancreatic triglyceride lipase.
J Biol Chem
.
1997;272
(1):
9-12.
PMID:
8995215
Andersson L, Carriére F, Lowe ME, Nilsson A, Verger R.
Pancreatic lipase-related protein 2 but not classical pancreatic lipase hydrolyzes galactolipids.
Biochim Biophys Acta
.
1996;1302
(3):
236-40.
PMID:
8765145
Lowe ME.
Mutation of the catalytic site Asp177 to Glu177 in human pancreatic lipase produces an active lipase with increased sensitivity to proteases.
Biochim Biophys Acta
.
1996;1302
(2):
177-83.
PMID:
8695668
Kullman J, Gisi C, Lowe ME.
Dexamethasone-regulated expression of pancreatic lipase and two related proteins in AR42J cells.
Am J Physiol
.
1996;270
(5 Pt 1):
G746-51.
PMID:
8967484
Jennens ML, Lowe ME.
Rat GP-3 is a pancreatic lipase with kinetic properties that differ from colipase-dependent pancreatic lipase.
J Lipid Res
.
1995;36
(11):
2374-82.
PMID:
8656075
Jennens ML, Lowe ME.
C-terminal domain of human pancreatic lipase is required for stability and maximal activity but not colipase reactivation.
J Lipid Res
.
1995;36
(5):
1029-36.
PMID:
7658150
Lowe ME.
Human pancreatic procolipase expressed in insect cells: purification and characterization.
Protein Expr Purif
.
1994;5
(6):
583-6.
PMID:
7858428
Jennens ML, Lowe ME.
A surface loop covering the active site of human pancreatic lipase influences interfacial activation and lipid binding.
J Biol Chem
.
1994;269
(41):
25470-4.
PMID:
7929247
Payne RM, Sims HF, Jennens ML, Lowe ME.
Rat pancreatic lipase and two related proteins: enzymatic properties and mRNA expression during development.
Am J Physiol
.
1994;266
(5 Pt 1):
G914-21.
PMCID:
PMC3523700
PMID:
8203536
Sims HF, Jennens ML, Lowe ME.
The human pancreatic lipase-encoding gene: structure and conservation of an Alu sequence in the lipase gene family.
Gene
.
1993;131
(2):
281-5.
PMID:
8406023
Lowe ME.
The catalytic site residues and interfacial binding of human pancreatic lipase.
J Biol Chem
.
1992;267
(24):
17069-73.
PMID:
1512245
Sims HF, Lowe ME.
The human colipase gene: isolation, chromosomal location, and tissue-specific expression.
Biochemistry
.
1992;31
(31):
7120-5.
PMID:
1643046
Kumar BV, Aleman-Gomez JA, Colwell N, Lopez-Candales A, Bosner MS, Spilburg CA, Lowe M, Lange LG.
Structure of the human pancreatic cholesterol esterase gene.
Biochemistry
.
1992;31
(26):
6077-81.
PMID:
1627550
Lowe ME.
Site-specific mutations in the COOH-terminus of placental alkaline phosphatase: a single amino acid change converts a phosphatidylinositol-glycan-anchored protein to a secreted protein.
J Cell Biol
.
1992;116
(3):
799-807.
PMCID:
PMC2289307
PMID:
1730777
Long CA, Bauer GS, Lowe ME, Strauss AW, Gast MJ.
Isolation and characterization of the gene from a human genome encoding 17 beta-estradiol dehydrogenase: a comparison of Jar and BeWo choriocarcinoma cell lines.
Am J Obstet Gynecol
.
1990;163
(6 Pt 1):
1976-81.
PMID:
2256510
Lowe ME, Strauss AW.
Expression of a Nagao-type, phosphatidylinositol-glycan anchored alkaline phosphatase in human choriocarcinomas.
Cancer Res
.
1990;50
(13):
3956-62.
PMID:
2162249
Lowe M, Strauss AW, Alpers R, Seetharam S, Alpers DH.
Molecular cloning and expression of a cDNA encoding the membrane-associated rat intestinal alkaline phosphatase.
Biochim Biophys Acta
.
1990;1037
(2):
170-7.
PMID:
2155025
Lowe ME, Rosenblum JL, McEwen P, Strauss AW.
Cloning and characterization of the human colipase cDNA.
Biochemistry
.
1990;29
(3):
823-8.
PMID:
2337598
Lowe ME, Rosenblum JL, Strauss AW.
Cloning and characterization of human pancreatic lipase cDNA.
J Biol Chem
.
1989;264
(33):
20042-8.
PMID:
2479644
Lowe ME, Nilsson B.
A method of purification of partially methylated alditol acetates in the methylation analysis of glycoproteins and glycopeptides.
Anal Biochem
.
1984;136
(1):
187-91.
PMID:
6711806
Lowe M, Nilsson B.
The structure of the complex type oligosaccharide from rabbit hepatic binding protein. A re-examination.
J Biol Chem
.
1983;258
(3):
1885-7.
PMID:
6822540
Lowe ME, Kempner ES.
Radiation inactivation of the glycoprotein, invertase.
J Biol Chem
.
1982;257
(21):
12478-80.
PMID:
6752136
Harford J, Lowe M, Tsunoo H, Ashwell G.
Immunological approaches to the study of membrane receptors. A monoclonal antibody that inhibits the binding of asialoglycoproteins to the rat liver receptor.
J Biol Chem
.
1982;257
(21):
12685-90.
PMID:
6290477
Lowe ME, Ashwell G.
Solubilization and assay of an hepatic receptor for the haptoglobin--hemoglobin complex.
Arch Biochem Biophys
.
1982;216
(2):
704-10.
PMID:
6287941
West CM, Lanza R, Rosenbloom J, Lowe M, Holtzer H, Avdalovic N.
Fibronectin alters the phenotypic properties of cultured chick embryo chondroblasts.
Cell
.
1979;17
(3):
491-501.
PMID:
476827
Lowe ME, Pacifici M, Holtzer H.
Effects of phorbol-12-myristate-13-acetate on the phenotypic program of cultured chondroblasts and fibroblasts.
Cancer Res
.
1978;38
(8):
2350-6.
PMID:
667832
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