Department of Pediatrics

Education

• BS, University of Wisconsin, 1997
• MD, Washington University, School of Medicine, 2005
• PhD, Washington University, School of Medicine, 2005

Training

• Residency, University of Michigan Hospitals and Health Centers, 2005 - 2007
• Fellowship, University of Michigan Hospitals and Health Centers, 2007 - 2010

Licensure and Board Certification

• 2009 - PresGeneral Pediatrics, # 95246
• 2009 - 2013MI, Michigan Medical Board
• 2011 - PresPediatric Hematology/Oncology, # 2409
• 2011 - 2015TX, Texas Medical Board
• 2013 - PresMO, Missouri Board of Registration for the Healing Arts

Honors and Awards

• Hilldale Undergraduate/Faculty Research Fellowship, University of Wisconsin-Madison, 1995
• Barry M. Goldwater Scholarship, University of Wisconsin-Madison, 1996
• Howard Hughes Medical Institute Fellowship, University of Wisconsin-Madison, 1996
• I. Jerome Flance Medical Science Traineeship, Washington University School of Medicine, 1999
• American College of Physicians Award for Excellence in Physical Diagnosis, Washington University School of Medicine, 2000
• Outstanding Teaching Assistant, Washington University School of Medicine, 2000
• David M. Kipnis Thesis Award, Washington University School of Medicine, 2005
• Spencer T. and Ann W. Olin Medical Science Fellowship, Washington University School of Medicine, 2005
• Pediatric Scientist Development Program Fellowship, University of Michigan Medical School, 2008
• Laurence Carolin Award, University of Michigan Medical School, 2010
• UT-Southwestern Disease Oriented Clinical Scholar Fellowship (declined), 2013
• Children's Discovery Institute Faculty Scholar, 2014
• Hyundai Hope Scholar, 2014
• St. Baldrick's Scholar Award, 2014
• Gabrielle's Angel Medical Research Award, 2016
• V Foundation Scholar Award, 2016
• Alex's Lemonade Stand Foundation 'A' Award, 2016
• American Society of Hematology Junior Faculty Scholar Award, 2016
• Hyundai hope Scholar, 2019
• Leukemia Lymphoma Society Scholar, 2021

Recent Publications view all (30)

Publication Co-Authors

Mary C. Dinauer, M.D., Ph.D.

Laura Schuettpelz, M.D, Ph.D.

Andrew Cluster

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Jeffrey Magee, M.D., Ph.D.

1. Rosen SF, Soung AL, Yang W, Shenjian A, Kanmogne M, Dave VA, Artyomov M, Magee JA, Klein RS. Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue resident T cells that drive synapse elimination during viral recovery Genome Medicine. 2022;14:108. PMID:36153630 
2. Bhattacharya S, Idol RA, Yang W, Rojas Marquez JD, Li Y, Huang G, Beatty WL, Atkinson JJ, Brumell JH, Bagaitkar J, Magee JA, Dinauer MC. Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in mice Blood. 2022;139:2855-2870. PMCID:PMC9101249  PMID:35357446 
3. Yuan O, Ugale A, de Marchi T, Anthonydhason V, Konturek-Ciesla A, Wan H, Eldeeb M, Drabe C, Jassinskaja M, Hansson J, Hidalgo I, Velasco-Hernandez T, Cammenga J, Magee JA, Nimeus E, Bryder D. A Somatic mutation in Moesin drives progression into acute myeloid leukemia Science Advances. 2022;8:eabm9987. PMCID:PMC9020775  PMID:35442741 
4. Li Y, Magee JA. Transcriptional reprogramming in neonatal hematopoietic stem and progenitor cells Experimental Hematology. 2021. doi:10.1016/j.exphem.2021.07.004  PMID:34303776 
5. Flerlage JE, Hiniker SM, Armenian S, Benya EC, Bobbey AJ, Chang V, Cooper S, Coulter DW, Cuglievan B, Hoppe BS, Isenalumhe L, Kelly K, Kersun L, Lamble AJ, Larrier NA, Magee J, Oduro K, Pacheco M, Price AP, Roberts KB, Smith CM, Sohani AR, Trovillion EM, Walling E, Xavier AC, Burns JL, Campbell M. Pediatric Hodgkin Lymphoma, Version 3.2021 Journal of the National Comprehensive Cancer Center Network. 2021;19:733-754. doi:10.6004/jnccn.2021.0027   PMID: 34214968 
6. Pikman Y, Tasian SK, Sulis ML, Stevenson K, Blonquist T, Winger BA, Cooper TM, Pauly M, Maloney KW, Burke MJ, Brown PA, Gossai N, McNeer JL, Shukla NN, Cole PD, Kahn JM, Chen J, Barth MJ, Magee JA, Gennarini L, Adhav AA, Clinton CM, Ocasio-Martinez N, Dr. Giacomo Gotti , Ms. Yuting Li , Dr. Shan Lin , Alma Imamovic , Dr. Cristina E. Tognon , Patel T, Faust HL, Contreras CF, Cremer A, Cortopassi W, Ruiz DG, Jacobson MP, Dharia NV, Su A, Robichaud A, Conway AS, Tarlock K, Stieglitz E, Place AE, Puissant A, Hunger SP, Kim AS, Lindeman NI, Gore L, Janeway KA, Silverman LB, Tyner JW, Harris M, Loh ML, Stegmaier K. . Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory or High-risk Leukemias: A Report from the LEAP Consortium Cancer Discovery. 2021;11:1424-1439. doi:10.1158/2159-8290.CD-20-0564  PMID:33563661 
7. Chen R, Okeyo-Owuor T, Patel RM, Casey EB, Cluster A, Yang, W, Magee JA. Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy Cell Reports. 2021;34:108751. doi:10.1016/j.celrep.2021.108751  PMID:33596429 
8. Magee JA and Signer RAJ. Developmental stage-specific changes in protein synthesis differentially sensitize hematopoietic stem cells and erythroid progenitors to impaired ribosome biogenesis Stem Cell Reports. 2021;16:20-28. doi:10.1016/j.stemcr.2020.11.017  PMCID:33440178  
9. Li Y, Kong W, Yang W, Patel RM, Casey EB, Okeyo-Owuor T, White JM, Porter SN, Morris SA, Magee JA. Single-cell analysis of neonatal HSC ontogeny reveals gradual and uncoordinated transcriptional reprogramming that begins before birth Cell Stem Cell. 2020;27:732-747. doi:10.1016/j.stem.2020.08.001   PMID:32822583 
10. Monlish DA, Greenberg ZJ, Bhatt ST, Leonard KM, Romine MP, Dong Q, Bendesky L, Duncavage EJ, Magee JA, Schuettpelz LG.. TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse model of MDS Experimental Hematology. 2020;88:42-55. doi:10.1016/j.exphem.2020.07.001   PMID:32652111 
11. Okeyo-Owuor T, Patel RM, Li Y, Yang W, Casey EB, Cluster AS, Porter SN, Bryder D, Magee JA. The efficiency of murine MLL-ENL driven leukemia initiation changes with age and peaks during neonatal development. Blood Advances. 2019;3(15):2388-2399. PMCID:PMC6693010  PMID:31405949 
12. Porter SN, Magee JA. PRKCH regulates hematopoietic stem cell function and predicts poor prognosis in acute myeloid leukemia. Exp Hematol. 2017. PMID:28596089 
13. Magee JA. Sleepwalking stem cells. Blood. 2017;129(14):1887-1888. PMCID:PMC5383876  PMID:28385766 
14. Porter SN, Cluster AS, Yang W, Busken KA, Patel RM, Ryoo JA, Magee JA. Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations. Elife. 2016;5. PMID:27879203 
15. Magee JA. Comment on: Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia. Br J Haematol. 2016. PMID:27766614 
16. Porter SN, Cluster AS, Signer RAJ, Voigtman J, Monlish DA, Schuettpelz LG, Magee JA. Pten cell autonomously modulates the hematopoietic stem cell response to inflammatory cytokines Stem Cell Reports. 2016;6(6):806-814. PMID:27185281 
17. Kraus M, Dolinski B, Rosahl TW, Magee JA. Protein kinase N3 deficiency impedes PI3-kinase pathway-driven leukemogenesis without affecting normal hematopoiesis. Leukemia. 2015;29(1):255-8. doi:10.1038/leu.2014.278  PMID:25234167 
18. Signer RA, Magee JA, Salic A, Morrison SJ. Haematopoietic stem cells require a highly regulated protein synthesis rate. Nature. 2014;509(7498):49-54. doi:10.1038/nature13035  PMCID:PMC4015626  PMID:24670665 
19. Li Q, Bohin N, Wen T, Ng V, Magee J, Chen SC, Shannon K, Morrison SJ. Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness. Nature. 2013;504(7478):143-7. doi:10.1038/nature12830  PMID:24284627 
20. Foley SB, Hildenbrand ZL, Soyombo AA, Magee JA, Wu Y, Oravecz-Wilson KI, Ross TS. Expression of BCR/ABL p210 from a knockin allele enhances bone marrow engraftment without inducing neoplasia. Cell Rep. 2013;5(1):51-60. doi:10.1016/j.celrep.2013.08.037  PMCID:PMC3832111  PMID:24095735 
21. Magee JA, Ikenoue T, Nakada D, Lee JY, Guan KL, Morrison SJ. Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. Cell Stem Cell. 2012;11(3):415-28. doi:10.1016/j.stem.2012.05.026  PMCID:PMC3447536  PMID:22958933 
22. Magee JA, Piskounova E, Morrison SJ. Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell. 2012;21(3):283-96. doi:10.1016/j.ccr.2012.03.003  PMID:22439924 
23. Chang LW, Nagarajan R, Magee JA, Milbrandt J, Stormo GD. A systematic model to predict transcriptional regulatory mechanisms based on overrepresentation of transcription factor binding profiles. Genome Res. 2006;16(3):405-13. doi:10.1101/gr.4303406  PMCID:PMC1415218  PMID:16449500 
24. Magee JA, Chang LW, Stormo GD, Milbrandt J. Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element. Endocrinology. 2006;147(1):590-8. doi:10.1210/en.2005-1001  PMID:16210365 
25. Magee JA, Abdulkadir SA, Milbrandt J. Haploinsufficiency at the Nkx3.1 locus. A paradigm for stochastic, dosage-sensitive gene regulation during tumor initiation. Cancer Cell. 2003;3(3):273-83. PMID:12676585 
26. Abdulkadir SA, Magee JA, Peters TJ, Kaleem Z, Naughton CK, Humphrey PA, Milbrandt J. Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Mol Cell Biol. 2002;22(5):1495-503. PMCID:PMC134699  PMID:11839815 
27. Magee J, Gordon JI, Whelan A. Bringing the human genome and the revolution in bioinformatics to the medical school classroom: a case report from Washington University School of Medicine. Acad Med. 2001;76(8):852-5. PMID:11500292 
28. Magee JA, Araki T, Patil S, Ehrig T, True L, Humphrey PA, Catalona WJ, Watson MA, Milbrandt J. Expression profiling reveals hepsin overexpression in prostate cancer. Cancer Res. 2001;61(15):5692-6. PMID:11479199 
29. Kim J, Magee J, Carroll SB. Intercompartmental signaling and the regulation of vestigial expression at the dorsoventral boundary of the developing Drosophila wing. Cold Spring Harb Symp Quant Biol. 1997;62:283-91. PMID:9598362 
30. Kim J, Sebring A, Esch JJ, Kraus ME, Vorwerk K, Magee J, Carroll SB. Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene. Nature. 1996;382(6587):133-8. doi:10.1038/382133a0  PMID:8700202