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Jeffrey Magee, M.D., Ph.D.
mageej@wustl.edu
Associate Professor, Division of Hematology-Oncology, Department of Pediatrics
Hematology and Oncology
phone: (314) 454-6018
View my lab
Education
BS,
University of Wisconsin
,
1997
MD,
Washington University, School of Medicine
,
2005
PhD,
Washington University, School of Medicine
,
2005
Training
Residency, University of Michigan Hospitals and Health Centers
,
2005
-
2007
Fellowship, University of Michigan Hospitals and Health Centers
,
2007
-
2010
Licensure and Board Certification
2009
-
Pres
General Pediatrics, # 95246
2009
-
2013
MI, Michigan Medical Board
2011
-
Pres
Pediatric Hematology/Oncology, # 2409
2011
-
2015
TX, Texas Medical Board
2013
-
Pres
MO, Missouri Board of Registration for the Healing Arts
Honors and Awards
Hilldale Undergraduate/Faculty Research Fellowship, University of Wisconsin-Madison
,
1995
Barry M. Goldwater Scholarship, University of Wisconsin-Madison
,
1996
Howard Hughes Medical Institute Fellowship, University of Wisconsin-Madison
,
1996
I. Jerome Flance Medical Science Traineeship, Washington University School of Medicine
,
1999
American College of Physicians Award for Excellence in Physical Diagnosis, Washington University School of Medicine
,
2000
Outstanding Teaching Assistant, Washington University School of Medicine
,
2000
David M. Kipnis Thesis Award, Washington University School of Medicine
,
2005
Spencer T. and Ann W. Olin Medical Science Fellowship, Washington University School of Medicine
,
2005
Pediatric Scientist Development Program Fellowship, University of Michigan Medical School
,
2008
Laurence Carolin Award, University of Michigan Medical School
,
2010
UT-Southwestern Disease Oriented Clinical Scholar Fellowship (declined)
,
2013
Children's Discovery Institute Faculty Scholar
,
2014
Hyundai Hope Scholar
,
2014
St. Baldrick's Scholar Award
,
2014
Gabrielle's Angel Medical Research Award
,
2016
V Foundation Scholar Award
,
2016
Alex's Lemonade Stand Foundation 'A' Award
,
2016
American Society of Hematology Junior Faculty Scholar Award
,
2016
Hyundai hope Scholar
,
2019
Leukemia Lymphoma Society Scholar
,
2021
Recent Publications
view all (29)
Publication Co-Authors
Laura Schuettpelz, M.D, Ph.D.
Andrew Cluster
Bhattacharya S, Idol RA, Yang W, Rojas Marquez JD, Li Y, Huang G, Beatty WL, Atkinson JJ, Brumell JH, Bagaitkar J, Magee JA, Dinauer MC.
Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in mice
Blood
.
2022;139:2855-2870.
PMCID:
PMC9101249
PMID:
35357446
Yuan O, Ugale A, de Marchi T, Anthonydhason V, Konturek-Ciesla A, Wan H, Eldeeb M, Drabe C, Jassinskaja M, Hansson J, Hidalgo I, Velasco-Hernandez T, Cammenga J, Magee JA, Nimeus E, Bryder D.
A Somatic mutation in Moesin drives progression into acute myeloid leukemia
Science Advances
.
2022;8:eabm9987.
PMCID:
PMC9020775
PMID:
35442741
Li Y, Magee JA.
Transcriptional reprogramming in neonatal hematopoietic stem and progenitor cells
Experimental Hematology
.
2021.
doi:
10.1016/j.exphem.2021.07.004
PMID:
34303776
Flerlage JE, Hiniker SM, Armenian S, Benya EC, Bobbey AJ, Chang V, Cooper S, Coulter DW, Cuglievan B, Hoppe BS, Isenalumhe L, Kelly K, Kersun L, Lamble AJ, Larrier NA, Magee J, Oduro K, Pacheco M, Price AP, Roberts KB, Smith CM, Sohani AR, Trovillion EM, Walling E, Xavier AC, Burns JL, Campbell M.
Pediatric Hodgkin Lymphoma, Version 3.2021
Journal of the National Comprehensive Cancer Center Network
.
2021;19:733-754.
doi:
10.6004/jnccn.2021.0027
PMID:
34214968
Pikman Y, Tasian SK, Sulis ML, Stevenson K, Blonquist T, Winger BA, Cooper TM, Pauly M, Maloney KW, Burke MJ, Brown PA, Gossai N, McNeer JL, Shukla NN, Cole PD, Kahn JM, Chen J, Barth MJ, Magee JA, Gennarini L, Adhav AA, Clinton CM, Ocasio-Martinez N, Dr. Giacomo Gotti , Ms. Yuting Li , Dr. Shan Lin , Alma Imamovic , Dr. Cristina E. Tognon , Patel T, Faust HL, Contreras CF, Cremer A, Cortopassi W, Ruiz DG, Jacobson MP, Dharia NV, Su A, Robichaud A, Conway AS, Tarlock K, Stieglitz E, Place AE, Puissant A, Hunger SP, Kim AS, Lindeman NI, Gore L, Janeway KA, Silverman LB, Tyner JW, Harris M, Loh ML, Stegmaier K. .
Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory or High-risk Leukemias: A Report from the LEAP Consortium
Cancer Discovery
.
2021;11:1424-1439.
doi:
10.1158/2159-8290.CD-20-0564
PMID:
33563661
Chen R, Okeyo-Owuor T, Patel RM, Casey EB, Cluster A, Yang, W, Magee JA.
Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy
Cell Reports
.
2021;34:108751.
doi:
10.1016/j.celrep.2021.108751
PMID:
33596429
Magee JA and Signer RAJ.
Developmental stage-specific changes in protein synthesis differentially sensitize hematopoietic stem cells and erythroid progenitors to impaired ribosome biogenesis
Stem Cell Reports
.
2021;16:20-28.
doi:
10.1016/j.stemcr.2020.11.017
PMCID:
33440178
Li Y, Kong W, Yang W, Patel RM, Casey EB, Okeyo-Owuor T, White JM, Porter SN, Morris SA, Magee JA.
Single-cell analysis of neonatal HSC ontogeny reveals gradual and uncoordinated transcriptional reprogramming that begins before birth
Cell Stem Cell
.
2020;27:732-747.
doi:
10.1016/j.stem.2020.08.001
PMID:
32822583
Monlish DA, Greenberg ZJ, Bhatt ST, Leonard KM, Romine MP, Dong Q, Bendesky L, Duncavage EJ, Magee JA, Schuettpelz LG..
TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse model of MDS
Experimental Hematology
.
2020;88:42-55.
doi:
10.1016/j.exphem.2020.07.001
PMID:
32652111
Okeyo-Owuor T, Patel RM, Li Y, Yang W, Casey EB, Cluster AS, Porter SN, Bryder D, Magee JA.
The efficiency of murine MLL-ENL driven leukemia initiation changes with age and peaks during neonatal development.
Blood Advances
.
2019;3
(15):
2388-2399.
PMCID:
PMC6693010
PMID:
31405949
Porter SN, Magee JA.
PRKCH regulates hematopoietic stem cell function and predicts poor prognosis in acute myeloid leukemia.
Exp Hematol
.
2017.
PMID:
28596089
Magee JA.
Sleepwalking stem cells.
Blood
.
2017;129
(14):
1887-1888.
PMCID:
PMC5383876
PMID:
28385766
Porter SN, Cluster AS, Yang W, Busken KA, Patel RM, Ryoo JA, Magee JA.
Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations.
Elife
.
2016;5.
PMID:
27879203
Magee JA.
Comment on: Genomics of primary chemoresistance and remission induction failure in paediatric and adult acute myeloid leukaemia.
Br J Haematol
.
2016.
PMID:
27766614
Porter SN, Cluster AS, Signer RAJ, Voigtman J, Monlish DA, Schuettpelz LG, Magee JA.
Pten cell autonomously modulates the hematopoietic stem cell response to inflammatory cytokines
Stem Cell Reports
.
2016;6
(6):
806-814.
PMID:
27185281
Kraus M, Dolinski B, Rosahl TW, Magee JA.
Protein kinase N3 deficiency impedes PI3-kinase pathway-driven leukemogenesis without affecting normal hematopoiesis.
Leukemia
.
2015;29
(1):
255-8.
doi:
10.1038/leu.2014.278
PMID:
25234167
Signer RA, Magee JA, Salic A, Morrison SJ.
Haematopoietic stem cells require a highly regulated protein synthesis rate.
Nature
.
2014;509
(7498):
49-54.
doi:
10.1038/nature13035
PMCID:
PMC4015626
PMID:
24670665
Li Q, Bohin N, Wen T, Ng V, Magee J, Chen SC, Shannon K, Morrison SJ.
Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness.
Nature
.
2013;504
(7478):
143-7.
doi:
10.1038/nature12830
PMID:
24284627
Foley SB, Hildenbrand ZL, Soyombo AA, Magee JA, Wu Y, Oravecz-Wilson KI, Ross TS.
Expression of BCR/ABL p210 from a knockin allele enhances bone marrow engraftment without inducing neoplasia.
Cell Rep
.
2013;5
(1):
51-60.
doi:
10.1016/j.celrep.2013.08.037
PMCID:
PMC3832111
PMID:
24095735
Magee JA, Ikenoue T, Nakada D, Lee JY, Guan KL, Morrison SJ.
Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression.
Cell Stem Cell
.
2012;11
(3):
415-28.
doi:
10.1016/j.stem.2012.05.026
PMCID:
PMC3447536
PMID:
22958933
Magee JA, Piskounova E, Morrison SJ.
Cancer stem cells: impact, heterogeneity, and uncertainty.
Cancer Cell
.
2012;21
(3):
283-96.
doi:
10.1016/j.ccr.2012.03.003
PMID:
22439924
Chang LW, Nagarajan R, Magee JA, Milbrandt J, Stormo GD.
A systematic model to predict transcriptional regulatory mechanisms based on overrepresentation of transcription factor binding profiles.
Genome Res
.
2006;16
(3):
405-13.
doi:
10.1101/gr.4303406
PMCID:
PMC1415218
PMID:
16449500
Magee JA, Chang LW, Stormo GD, Milbrandt J.
Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element.
Endocrinology
.
2006;147
(1):
590-8.
doi:
10.1210/en.2005-1001
PMID:
16210365
Magee JA, Abdulkadir SA, Milbrandt J.
Haploinsufficiency at the Nkx3.1 locus. A paradigm for stochastic, dosage-sensitive gene regulation during tumor initiation.
Cancer Cell
.
2003;3
(3):
273-83.
PMID:
12676585
Abdulkadir SA, Magee JA, Peters TJ, Kaleem Z, Naughton CK, Humphrey PA, Milbrandt J.
Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia.
Mol Cell Biol
.
2002;22
(5):
1495-503.
PMCID:
PMC134699
PMID:
11839815
Magee J, Gordon JI, Whelan A.
Bringing the human genome and the revolution in bioinformatics to the medical school classroom: a case report from Washington University School of Medicine.
Acad Med
.
2001;76
(8):
852-5.
PMID:
11500292
Magee JA, Araki T, Patil S, Ehrig T, True L, Humphrey PA, Catalona WJ, Watson MA, Milbrandt J.
Expression profiling reveals hepsin overexpression in prostate cancer.
Cancer Res
.
2001;61
(15):
5692-6.
PMID:
11479199
Kim J, Magee J, Carroll SB.
Intercompartmental signaling and the regulation of vestigial expression at the dorsoventral boundary of the developing Drosophila wing.
Cold Spring Harb Symp Quant Biol
.
1997;62:283-91.
PMID:
9598362
Kim J, Sebring A, Esch JJ, Kraus ME, Vorwerk K, Magee J, Carroll SB.
Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene.
Nature
.
1996;382
(6587):
133-8.
doi:
10.1038/382133a0
PMID:
8700202
Last updated: 06/28/2022
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