Department of Pediatrics

Education

• MA, Arizona State University, 2010
• PhD, Arizona State University, 2014

Training

• Postdoctoral Research Associate, Washington University School of Medicine, 2014 - 2016
• Postdoctoral Research Associate, Washington University School of Medicine, 2016 - 2019

Honors and Awards

• NIAMS R01 Diversity Supplement Awardee, 2017 - 2020
• Institute for Clinical and Translational Sciences (ICTS) Just in Time Grant Awardee, 2019

Recent Publications view all (15)

Publication Co-Authors

Todd Druley, M.D., Ph.D.

Ina E. Amarillo, PhD FACMG ErCLG

Celeste Karch

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Brooke Sadler

1. Sadler B, Wilborn J, Antunes L, Kuensting T, Hale AT, Gannon SR, McCall K, Cruchaga C, Harms M, Voisin N, Reymond A, Cappuccio G, Burnetti-Pierri N, Tartaglia M, Niceta M, Leoni C, Zampino G, Ashley-Koch A, Urbizu A, Garrett ME, Soldano K, Macaya A, Conrad D, Strahle J, Dobbs MB, Turner TN, Shannon CN, Brockmeyer D, Limbrick DD, Gurnett CA, Haller G. Rare and de novo coding variants in chromodomain genes in Chiari I malformation. Am J Hum Genet. 2020. PMID:33352116 
2. Sadler B, Haller G, Antunes L, Nikolov M, Amarillo I, Coe B, Dobbs MB, Gurnett CA. Rare and de novo duplications containing SHOX in clubfoot. J Med Genet. 2020. PMID:32518174 
3. Sadler B, Kuensting T, Strahle J, Park TS, Smyth M, Limbrick DD, Dobbs MB, Haller G, Gurnett CA. Prevalence and Impact of Underlying Diagnosis and Comorbidities on Chiari 1 Malformation. Pediatr Neurol. 2020;106:32-37. PMCID:PMC7156318  PMID:32113729 
4. Haller G, Sadler B, Kuensting T, Lakshman N, Greenberg JK, Strahle JM, Park TS, Dobbs MB, Gurnett CA, Limbrick DD. Obex position is associated with syringomyelia and use of posterior fossa decompression among patients with Chiari I malformation. J Neurosurg Pediatr. 2020;1-8. PMID:32276247 
5. Sadler, B., Gurnett, C., & Dobbs, M. . The Genetics of Idiopathic and Syndromic Clubfoot Journal of Children’s Orthopaedics. 2019;(13):238-244. PMCID:PMC6598048  
6. Brooke Sadler, J. Evan Sadler. How I learned to stop researching and live in the moment Neurology. 2019;92(24):1157-58. doi:https://doi.org/10.1212/WNL.0000000000007656   
7. Sadler B, Haller G, Antunes L, Bledsoe X, Morcuende J, Giampietro P, Raggio C, Miller N, Kidane Y, Wise CA, Amarillo I, Walton N, Seeley M, Johnson D, Jenkins C, Jenkins T, Oetjens M, Tong RS, Druley TE, Dobbs MB, Gurnett CA. Distal chromosome 16p11.2 duplications containing SH2B1 in patients with scoliosis. J Med Genet. 2019;56(7):427-433. PMCID:PMC6592771  PMID:30803986 
8. Haller G, McCall K, Jenkitkasemwong S, Sadler B, Antunes L, Nikolov M, Whittle J, Upshaw Z, Shin J, Baschal E, Cruchaga C, Harms M, Raggio C, Morcuende JA, Giampietro P, Miller NH, Wise C, Gray RS, Solnica-Krezel L, Knutson M, Dobbs MB, Gurnett CA. A missense variant in SLC39A8 is associated with severe idiopathic scoliosis. Nat Commun. 2018;9(1):4171. PMCID:PMC6177404  PMID:30301978 
9. Sadler BE, Grant JD, Duncan AE, Sartor CE, Waldron M, Heath AC, Bucholz KK. The Influence of Paternal Separation, Paternal History of Alcohol Use Disorder Risk, and Early Substance Use on Offspring Educational Attainment by Young Adulthood. J Stud Alcohol Drugs. 2017;78(3):426-434. PMCID:PMC5440366  PMID:28499110 
10. Sartor CE, Grant JD, Agrawal A, Sadler B, Madden PA, Heath AC, Bucholz KK. Genetic and environmental contributions to initiation of cigarette smoking in young African-American and European-American women. Drug Alcohol Depend. 2015;157:54-9. PMCID:PMC4663123  PMID:26482091 
11. Sadler B, Haller G, Edenberg H, Tischfield J, Brooks A, Kramer J, Schuckit M, Nurnberger J, Goate A. Positive Selection on Loci Associated with Drug and Alcohol Dependence. PLoS One. 2015;10(8):e0134393. PMCID:PMC4536217  PMID:26270548 
12. Culverhouse RC, Johnson EO, Breslau N, Hatsukami DK, Sadler B, Brooks AI, Hesselbrock VM, Schuckit MA, Tischfield JA, Goate AM, Saccone NL, Bierut LJ. Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans. Addiction. 2014;109(5):814-22. PMCID:PMC3984604  PMID:24401102 
13. Sadler B, Haller G, Agrawal A, Culverhouse R, Bucholz K, Brooks A, Tischfield J, Johnson EO, Edenberg H, Schuckit M, Saccone N, Bierut L, Goate A. Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: evidence for pleiotropy. Sci Rep. 2014;4:4497. PMCID:PMC4894386  PMID:24675634 
14. Kauwe JS, Cruchaga C, Karch CM, Sadler B, Lee M, Mayo K, Latu W, Su'a M, Fagan AM, Holtzman DM, Morris JC, Alzheimer's Disease Neuroimaging Initiative., Goate AM. Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease. PLoS One. 2011;6(2):e15918. PMCID:PMC3036586  PMID:21347408 
15. Roseman CC, Willmore KE, Rogers J, Hildebolt C, Sadler BE, Richtsmeier JT, Cheverud JM. Genetic and environmental contributions to variation in baboon cranial morphology. Am J Phys Anthropol. 2010;143(1):1-12. PMCID:PMC3258659  PMID:20623673