Department of Pediatrics

Education

• MA, Arizona State University, 2010
• PhD, Arizona State University, 2014

Training

• Postdoctoral Research Associate, Washington University School of Medicine, 2014 - 2016
• Postdoctoral Research Associate, Washington University School of Medicine, 2016 - 2019

Honors and Awards

• NIAMS R01 Diversity Supplement Awardee, 2017 - 2020
• Institute for Clinical and Translational Sciences (ICTS) Just in Time Grant Awardee, 2019

Recent Publications view all (25)

Publication Co-Authors

Ina E. Amarillo, PhD FACMG ErCLG

Celeste Karch

Jorge Di Paola

Washington University has a long tradition of collaboration amongst colleagues.The faculty above have co-authored publications with Brooke Sadler

1. Sadler B. Novel genotype-phenotype interaction in HIT. Blood. 2022;140(3):168-169. PMID:35862092 
2. Christopherson PA, Haberichter SL, Flood VH, Perry CL, Sadler BE, Bellissimo DB, Di Paola J, Montgomery RR, Zimmerman Program Investigators.. Molecular pathogenesis and heterogeneity in type 3 VWD families in U.S. Zimmerman program. J Thromb Haemost. 2022;20(7):1576-1588. PMID:35343054 
3. Sadler B, Castaman G, O'Donnell JS. von Willebrand disease and von Willebrand factor. Haemophilia. 2022;28 Suppl 4:11-17. PMCID:PMC9094051  PMID:35521725 
4. Sadler B, Minard CG, Haller G, Gurnett CA, O'Brien SH, Wheeler A, Jain S, Sharma M, Zia A, Kulkarni R, Mullins E, Ragni MV, Sidonio R, Dietrich JE, Kouides PA, Di Paola J, Srivaths L. Whole-exome analysis of adolescents with low VWF and heavy menstrual bleeding identifies novel genetic associations. Blood Adv. 2022;6(2):420-428. PMCID:PMC8791588  PMID:34807970 
5. Yang C, Farias FHG, Ibanez L, Suhy A, Sadler B, Fernandez MV, Wang F, Bradley JL, Eiffert B, Bahena JA, Budde JP, Li Z, Dube U, Sung YJ, Mihindukulasuriya KA, Morris JC, Fagan AM, Perrin RJ, Benitez BA, Rhinn H, Harari O, Cruchaga C. Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders. Nat Neurosci. 2021. PMID:34239129 
6. Mazer MB, Turnbull IR, Miles S, Blood TM, Sadler B, Hess A, Botney MD, Martin RS, Bosanquet JP, Striker DA, Anand NS, Morre M, Caldwell CC, Brakenridge SC, Moldawer LL, Di Paola JA, Hotchkiss RS, Remy KE. Interleukin-7 Reverses Lymphopenia and Improves T-Cell Function in Coronavirus Disease 2019 Patient With Inborn Error of Toll-Like Receptor 3: A Case Report. Crit Care Explor. 2021;3(7):e0500. PMCID:PMC8322565  PMID:34345826 
7. Sadler B, Skidmore A, Gewirtz J, Anderson RCE, Haller G, Ackerman LL, Adelson PD, Ahmed R, Albert GW, Aldana PR, Alden TD, Averill C, Baird LC, Bauer DF, Bethel-Anderson T, Bierbrauer KS, Bonfield CM, Brockmeyer DL, Chern JJ, Couture DE, Daniels DJ, Dlouhy BJ, Durham SR, Ellenbogen RG, Eskandari R, Fuchs HE, George TM, Grant GA, Graupman PC, Greene S, Greenfield JP, Gross NL, Guillaume DJ, Hankinson TC, Heuer GG, Iantosca M, Iskandar BJ, Jackson EM, Jea AH, Johnston JM, Keating RF, Khan N, Krieger MD, Leonard JR, Maher CO, Mangano FT, Mapstone TB, McComb JG, McEvoy SD, Meehan T, Menezes AH, Muhlbauer M, Oakes WJ, Olavarria G, O'Neill BR, Ragheb J, Selden NR, Shah MN, Shannon CN, Smith J, Smyth MD, Stone SSD, Tuite GF, Wait SD, Wellons JC, Whitehead WE, Park TS, Limbrick DD, Strahle JM. Extradural decompression versus duraplasty in Chiari malformation type I with syrinx: outcomes on scoliosis from the Park-Reeves Syringomyelia Research Consortium. J Neurosurg Pediatr. 2021;1-9. PMID:34144521 
8. Sadler B, Wilborn J, Antunes L, Kuensting T, Hale AT, Gannon SR, McCall K, Cruchaga C, Harms M, Voisin N, Reymond A, Cappuccio G, Brunetti-Pierri N, Tartaglia M, Niceta M, Leoni C, Zampino G, Ashley-Koch A, Urbizu A, Garrett ME, Soldano K, Macaya A, Conrad D, Strahle J, Dobbs MB, Turner TN, Shannon CN, Brockmeyer D, Limbrick DD, Gurnett CA, Haller G. Rare and de novo coding variants in chromodomain genes in Chiari I malformation. Am J Hum Genet. 2021;108(3):530-531. PMCID:PMC8008482  PMID:33667397 
9. Sadler B, Christopherson P, Haller G, Montgomery RR, Di Paola J, Investigators TZP. VWF antigen levels are associated with burden of rare nonsynonymous variants in the VWF gene. Blood. 2021. PMID:33556167 
10. Sadler B, Wilborn J, Antunes L, Kuensting T, Hale AT, Gannon SR, McCall K, Cruchaga C, Harms M, Voisin N, Reymond A, Cappuccio G, Brunetti-Pierri N, Tartaglia M, Niceta M, Leoni C, Zampino G, Ashley-Koch A, Urbizu A, Garrett ME, Soldano K, Macaya A, Conrad D, Strahle J, Dobbs MB, Turner TN, Shannon CN, Brockmeyer D, Limbrick DD, Gurnett CA, Haller G. Rare and de novo coding variants in chromodomain genes in Chiari I malformation. Am J Hum Genet. 2021;108(2):368. PMCID:PMC7895838  PMID:33545031 
11. Sadler B, Wilborn J, Antunes L, Kuensting T, Hale AT, Gannon SR, McCall K, Cruchaga C, Harms M, Voisin N, Reymond A, Cappuccio G, Burnetti-Pierri N, Tartaglia M, Niceta M, Leoni C, Zampino G, Ashley-Koch A, Urbizu A, Garrett ME, Soldano K, Macaya A, Conrad D, Strahle J, Dobbs MB, Turner TN, Shannon CN, Brockmeyer D, Limbrick DD, Gurnett CA, Haller G. Rare and de novo coding variants in chromodomain genes in Chiari I malformation. Am J Hum Genet. 2020. PMID:33352116 
12. Sadler B, Haller G, Antunes L, Nikolov M, Amarillo I, Coe B, Dobbs MB, Gurnett CA. Rare and de novo duplications containing SHOX in clubfoot. J Med Genet. 2020. PMID:32518174 
13. Sadler B, Kuensting T, Strahle J, Park TS, Smyth M, Limbrick DD, Dobbs MB, Haller G, Gurnett CA. Prevalence and Impact of Underlying Diagnosis and Comorbidities on Chiari 1 Malformation. Pediatr Neurol. 2020;106:32-37. PMCID:PMC7156318  PMID:32113729 
14. Haller G, Sadler B, Kuensting T, Lakshman N, Greenberg JK, Strahle JM, Park TS, Dobbs MB, Gurnett CA, Limbrick DD. Obex position is associated with syringomyelia and use of posterior fossa decompression among patients with Chiari I malformation. J Neurosurg Pediatr. 2020;1-8. PMID:32276247 
15. Sadler, B., Gurnett, C., & Dobbs, M. . The Genetics of Idiopathic and Syndromic Clubfoot Journal of Children’s Orthopaedics. 2019;(13):238-244. PMCID:PMC6598048  
16. Brooke Sadler, J. Evan Sadler. How I learned to stop researching and live in the moment Neurology. 2019;92(24):1157-58. doi:https://doi.org/10.1212/WNL.0000000000007656   
17. Sadler B, Haller G, Antunes L, Bledsoe X, Morcuende J, Giampietro P, Raggio C, Miller N, Kidane Y, Wise CA, Amarillo I, Walton N, Seeley M, Johnson D, Jenkins C, Jenkins T, Oetjens M, Tong RS, Druley TE, Dobbs MB, Gurnett CA. Distal chromosome 16p11.2 duplications containing SH2B1 in patients with scoliosis. J Med Genet. 2019;56(7):427-433. PMCID:PMC6592771  PMID:30803986 
18. Haller G, McCall K, Jenkitkasemwong S, Sadler B, Antunes L, Nikolov M, Whittle J, Upshaw Z, Shin J, Baschal E, Cruchaga C, Harms M, Raggio C, Morcuende JA, Giampietro P, Miller NH, Wise C, Gray RS, Solnica-Krezel L, Knutson M, Dobbs MB, Gurnett CA. A missense variant in SLC39A8 is associated with severe idiopathic scoliosis. Nat Commun. 2018;9(1):4171. PMCID:PMC6177404  PMID:30301978 
19. Sadler BE, Grant JD, Duncan AE, Sartor CE, Waldron M, Heath AC, Bucholz KK. The Influence of Paternal Separation, Paternal History of Alcohol Use Disorder Risk, and Early Substance Use on Offspring Educational Attainment by Young Adulthood. J Stud Alcohol Drugs. 2017;78(3):426-434. PMCID:PMC5440366  PMID:28499110 
20. Sartor CE, Grant JD, Agrawal A, Sadler B, Madden PA, Heath AC, Bucholz KK. Genetic and environmental contributions to initiation of cigarette smoking in young African-American and European-American women. Drug Alcohol Depend. 2015;157:54-9. PMCID:PMC4663123  PMID:26482091 
21. Sadler B, Haller G, Edenberg H, Tischfield J, Brooks A, Kramer J, Schuckit M, Nurnberger J, Goate A. Positive Selection on Loci Associated with Drug and Alcohol Dependence. PLoS One. 2015;10(8):e0134393. PMCID:PMC4536217  PMID:26270548 
22. Culverhouse RC, Johnson EO, Breslau N, Hatsukami DK, Sadler B, Brooks AI, Hesselbrock VM, Schuckit MA, Tischfield JA, Goate AM, Saccone NL, Bierut LJ. Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans. Addiction. 2014;109(5):814-22. PMCID:PMC3984604  PMID:24401102 
23. Sadler B, Haller G, Agrawal A, Culverhouse R, Bucholz K, Brooks A, Tischfield J, Johnson EO, Edenberg H, Schuckit M, Saccone N, Bierut L, Goate A. Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: evidence for pleiotropy. Sci Rep. 2014;4:4497. PMCID:PMC4894386  PMID:24675634 
24. Kauwe JS, Cruchaga C, Karch CM, Sadler B, Lee M, Mayo K, Latu W, Su'a M, Fagan AM, Holtzman DM, Morris JC, Alzheimer's Disease Neuroimaging Initiative., Goate AM. Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease. PLoS One. 2011;6(2):e15918. PMCID:PMC3036586  PMID:21347408 
25. Roseman CC, Willmore KE, Rogers J, Hildebolt C, Sadler BE, Richtsmeier JT, Cheverud JM. Genetic and environmental contributions to variation in baboon cranial morphology. Am J Phys Anthropol. 2010;143(1):1-12. PMCID:PMC3258659  PMID:20623673