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Brooke Sadler
sadler@wustl.edu
phone:
Education
MA,
Arizona State University
,
2010
PhD,
Arizona State University
,
2014
Training
Postdoctoral Research Associate, Washington University School of Medicine
,
2014
-
2016
Postdoctoral Research Associate, Washington University School of Medicine
,
2016
-
2019
Honors and Awards
NIAMS R01 Diversity Supplement Awardee
,
2017
- 2020
Institute for Clinical and Translational Sciences (ICTS) Just in Time Grant Awardee
,
2019
Recent Publications
view all (15)
Publication Co-Authors
Todd Druley, M.D., Ph.D.
Ina E. Amarillo, PhD FACMG ErCLG
Celeste Karch
Sadler B, Wilborn J, Antunes L, Kuensting T, Hale AT, Gannon SR, McCall K, Cruchaga C, Harms M, Voisin N, Reymond A, Cappuccio G, Burnetti-Pierri N, Tartaglia M, Niceta M, Leoni C, Zampino G, Ashley-Koch A, Urbizu A, Garrett ME, Soldano K, Macaya A, Conrad D, Strahle J, Dobbs MB, Turner TN, Shannon CN, Brockmeyer D, Limbrick DD, Gurnett CA, Haller G.
Rare and de novo coding variants in chromodomain genes in Chiari I malformation.
Am J Hum Genet
.
2020.
PMID:
33352116
Sadler B, Haller G, Antunes L, Nikolov M, Amarillo I, Coe B, Dobbs MB, Gurnett CA.
Rare and
de novo
duplications containing
SHOX
in clubfoot.
J Med Genet
.
2020.
PMID:
32518174
Sadler B, Kuensting T, Strahle J, Park TS, Smyth M, Limbrick DD, Dobbs MB, Haller G, Gurnett CA.
Prevalence and Impact of Underlying Diagnosis and Comorbidities on Chiari 1 Malformation.
Pediatr Neurol
.
2020;106:32-37.
PMCID:
PMC7156318
PMID:
32113729
Haller G, Sadler B, Kuensting T, Lakshman N, Greenberg JK, Strahle JM, Park TS, Dobbs MB, Gurnett CA, Limbrick DD.
Obex position is associated with syringomyelia and use of posterior fossa decompression among patients with Chiari I malformation.
J Neurosurg Pediatr
.
2020;1-8.
PMID:
32276247
Sadler, B., Gurnett, C., & Dobbs, M. .
The Genetics of Idiopathic and Syndromic Clubfoot
Journal of Children’s Orthopaedics
.
2019;(13):238-244.
PMCID:
PMC6598048
Brooke Sadler, J. Evan Sadler.
How I learned to stop researching and live in the moment
Neurology
.
2019;92
(24):
1157-58.
doi:
https://doi.org/10.1212/WNL.0000000000007656
Sadler B, Haller G, Antunes L, Bledsoe X, Morcuende J, Giampietro P, Raggio C, Miller N, Kidane Y, Wise CA, Amarillo I, Walton N, Seeley M, Johnson D, Jenkins C, Jenkins T, Oetjens M, Tong RS, Druley TE, Dobbs MB, Gurnett CA.
Distal chromosome 16p11.2 duplications containing
SH2B1
in patients with scoliosis.
J Med Genet
.
2019;56
(7):
427-433.
PMCID:
PMC6592771
PMID:
30803986
Haller G, McCall K, Jenkitkasemwong S, Sadler B, Antunes L, Nikolov M, Whittle J, Upshaw Z, Shin J, Baschal E, Cruchaga C, Harms M, Raggio C, Morcuende JA, Giampietro P, Miller NH, Wise C, Gray RS, Solnica-Krezel L, Knutson M, Dobbs MB, Gurnett CA.
A missense variant in SLC39A8 is associated with severe idiopathic scoliosis.
Nat Commun
.
2018;9
(1):
4171.
PMCID:
PMC6177404
PMID:
30301978
Sadler BE, Grant JD, Duncan AE, Sartor CE, Waldron M, Heath AC, Bucholz KK.
The Influence of Paternal Separation, Paternal History of Alcohol Use Disorder Risk, and Early Substance Use on Offspring Educational Attainment by Young Adulthood.
J Stud Alcohol Drugs
.
2017;78
(3):
426-434.
PMCID:
PMC5440366
PMID:
28499110
Sartor CE, Grant JD, Agrawal A, Sadler B, Madden PA, Heath AC, Bucholz KK.
Genetic and environmental contributions to initiation of cigarette smoking in young African-American and European-American women.
Drug Alcohol Depend
.
2015;157:54-9.
PMCID:
PMC4663123
PMID:
26482091
Sadler B, Haller G, Edenberg H, Tischfield J, Brooks A, Kramer J, Schuckit M, Nurnberger J, Goate A.
Positive Selection on Loci Associated with Drug and Alcohol Dependence.
PLoS One
.
2015;10
(8):
e0134393.
PMCID:
PMC4536217
PMID:
26270548
Culverhouse RC, Johnson EO, Breslau N, Hatsukami DK, Sadler B, Brooks AI, Hesselbrock VM, Schuckit MA, Tischfield JA, Goate AM, Saccone NL, Bierut LJ.
Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans.
Addiction
.
2014;109
(5):
814-22.
PMCID:
PMC3984604
PMID:
24401102
Sadler B, Haller G, Agrawal A, Culverhouse R, Bucholz K, Brooks A, Tischfield J, Johnson EO, Edenberg H, Schuckit M, Saccone N, Bierut L, Goate A.
Variants near CHRNB3-CHRNA6 are associated with DSM-5 cocaine use disorder: evidence for pleiotropy.
Sci Rep
.
2014;4:4497.
PMCID:
PMC4894386
PMID:
24675634
Kauwe JS, Cruchaga C, Karch CM, Sadler B, Lee M, Mayo K, Latu W, Su'a M, Fagan AM, Holtzman DM, Morris JC, Alzheimer's Disease Neuroimaging Initiative., Goate AM.
Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.
PLoS One
.
2011;6
(2):
e15918.
PMCID:
PMC3036586
PMID:
21347408
Roseman CC, Willmore KE, Rogers J, Hildebolt C, Sadler BE, Richtsmeier JT, Cheverud JM.
Genetic and environmental contributions to variation in baboon cranial morphology.
Am J Phys Anthropol
.
2010;143
(1):
1-12.
PMCID:
PMC3258659
PMID:
20623673
Last updated: 12/29/2020
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